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INPLEASEAVOID
The SGC is a not-for-profit organization which accelerates research by making all its research output available to the scientific community with no strings attached, and by creating an open collaborative network of scientists in hundreds of universities around the THE VIRAL INTERRUPTION MEDICINES INITIATIVE (VIMI): OPEN In an opinion piece to Canada's The Hill Times, Drs Richard Gold, Tania Bubela, Aled Edwards and John Bamforth announced the creation of the Viral Interruption Medicines Initiative (VIMI). The partnership will leverage open science to develop anti-viral drugs in anticipation for future pandemics. Full article below and here. Canada needs a proactive pandemic innovationSGC OXFORD | SGC
The SGC Oxford laboratories, under the direction of Prof. Chas Bountra, are housed within the University's Old Road Campus located in Headington, Oxford. SGC Oxford is part of the Nuffield Department of Clinical Medicine and scientists at SGC Oxford are affiliated with several University Departments including the Kennedy Institute and theSGC OXFORD | SGC
SGC Oxford seeks to generate high quality reagents to accelerate the discovery of new medicines and place them into the public domain without restriction.Using 3D structures of human proteins and the reagents generated as part of the structure determination process as well as the chemical probes identified, we work with organisations within Oxford, the UK and the rest of the world to furtherSGC VECTORS
This table shows data for SGC vectors - click the Clone Vector ID for a PDF information sheet for the vector. Links to AddGene to purchase vectors are in the Description column. Links to AddGene and Source BioScience to purchase vectors are in the Description column Clone Vector ID GenBank Deposition ID SGC Site Description pBacMam2-SDiEx-LIC Toronto Baculovirus and mammalian PROTEIN PRODUCTION MATERIALS AND METHODS The SGC is providing expression and purification protocols for the following proteins that have been successfully purified in ourlaboratories.
| SGC
Overview. The normal development of our tissues, body shape and size is strictly coordinated. Secreted growth hormones and cytokines signal between cells to regulate the key physiological processes of growth and differentiation as well as responses to injury and infection. Inappropriate growth control is a defining feature of human cancerBILL ZUERCHER
william.zuercher@unc.edu. Chemical Probes. Bill Zuercher is Principal Investigator, Target Validation at the SGC-UNC and Research Associate Professor in the Division of Chemical Biology and Medicinal Chemistry in the UNC Eshelman School of Pharmacy. He is interested in using chemistry to elucidate biology, particularly through the design VECTOR INFORMATION SHEET Vector information sheet Dated: 8th May 2013 Vector Name pFB-6HZB Source Pravin Mahajan Sequence accession/link Description Baculovirus transfer vector with His 6 STRUCTURE-BASED DESIGN OF AN IN VIVO ACTIVE SELECTIVE BRD9 6 those reported for other bromodomains.8 Indeed, similar binding activity was observed towards BET family members for both fragments, highlighting the challenge of achieving high selectivityagainst
SGC | STRUCTURAL GENOMICS CONSORTIUMNEWSCAREERSPUBLICATIONSCONTACTLOGINPLEASEAVOID
The SGC is a not-for-profit organization which accelerates research by making all its research output available to the scientific community with no strings attached, and by creating an open collaborative network of scientists in hundreds of universities around the THE VIRAL INTERRUPTION MEDICINES INITIATIVE (VIMI): OPEN In an opinion piece to Canada's The Hill Times, Drs Richard Gold, Tania Bubela, Aled Edwards and John Bamforth announced the creation of the Viral Interruption Medicines Initiative (VIMI). The partnership will leverage open science to develop anti-viral drugs in anticipation for future pandemics. Full article below and here. Canada needs a proactive pandemic innovationSGC OXFORD | SGC
The SGC Oxford laboratories, under the direction of Prof. Chas Bountra, are housed within the University's Old Road Campus located in Headington, Oxford. SGC Oxford is part of the Nuffield Department of Clinical Medicine and scientists at SGC Oxford are affiliated with several University Departments including the Kennedy Institute and theSGC OXFORD | SGC
SGC Oxford seeks to generate high quality reagents to accelerate the discovery of new medicines and place them into the public domain without restriction.Using 3D structures of human proteins and the reagents generated as part of the structure determination process as well as the chemical probes identified, we work with organisations within Oxford, the UK and the rest of the world to furtherSGC VECTORS
This table shows data for SGC vectors - click the Clone Vector ID for a PDF information sheet for the vector. Links to AddGene to purchase vectors are in the Description column. Links to AddGene and Source BioScience to purchase vectors are in the Description column Clone Vector ID GenBank Deposition ID SGC Site Description pBacMam2-SDiEx-LIC Toronto Baculovirus and mammalian PROTEIN PRODUCTION MATERIALS AND METHODS The SGC is providing expression and purification protocols for the following proteins that have been successfully purified in ourlaboratories.
| SGC
Overview. The normal development of our tissues, body shape and size is strictly coordinated. Secreted growth hormones and cytokines signal between cells to regulate the key physiological processes of growth and differentiation as well as responses to injury and infection. Inappropriate growth control is a defining feature of human cancerBILL ZUERCHER
william.zuercher@unc.edu. Chemical Probes. Bill Zuercher is Principal Investigator, Target Validation at the SGC-UNC and Research Associate Professor in the Division of Chemical Biology and Medicinal Chemistry in the UNC Eshelman School of Pharmacy. He is interested in using chemistry to elucidate biology, particularly through the design VECTOR INFORMATION SHEET Vector information sheet Dated: 8th May 2013 Vector Name pFB-6HZB Source Pravin Mahajan Sequence accession/link Description Baculovirus transfer vector with His 6 STRUCTURE-BASED DESIGN OF AN IN VIVO ACTIVE SELECTIVE BRD9 6 those reported for other bromodomains.8 Indeed, similar binding activity was observed towards BET family members for both fragments, highlighting the challenge of achieving high selectivityagainst
SGC | STRUCTURAL GENOMICS CONSORTIUM The SGC is a not-for-profit organization which accelerates research by making all its research output available to the scientific community with no strings attached, and by creating an open collaborative network of scientists in hundreds of universities around theSGC LABORATORIES
SGC laboratories The SGC operates from four academic institutions - the University of Toronto, the Goethe University Frankfurt, the University of North Carolina Chapel Hill and the State University of Campinas (Unicamp) in Brazil - ensuring the SGC labs a remarkable level of engagement and exchange with their respective local academiccommunities.
SGC OXFORD | SGC
SGC Oxford seeks to generate high quality reagents to accelerate the discovery of new medicines and place them into the public domain without restriction.Using 3D structures of human proteins and the reagents generated as part of the structure determination process as well as the chemical probes identified, we work with organisations within Oxford, the UK and the rest of the world to further SDDC - STRUCTURE-GUIDED DRUG DISCOVERY COALITION Medicinal Chemistry projects are focussed on the best disease-validated targets only. Small-molecule drug-discovery, as typified by pharmaceutical industry practice, is an extremely high-risk, lengthy and expensive enterprise. The attrition rate from the starting of an early Discovery project to a launched drug is in the range of 95-99%, depending on indication.DDR-TRK-1 | SGC
DDR-TRK-1 is a chemical probe for the DDR and TRK kinases with good in vitro and in vivo potency. DDR-TRK-1 inhibits colony formation and migration of Panc-1 pancreatic cancer cells. In cellular and mouse models of lung fibrosis, DDR-TRK-1 inhibits signaling, expression of fibrotic markers and fibrotic features such as hydroxprolineexpression.
QUICK FACTS
SGC target ID . UBC63. QUICK FACTS . UBE2Q2, ubiquitin-conjugating enzyme E2Q (putative) 2; DKFZp762C143; LOC92912; Updated . 11.June.07 . Protein Size . 42818.2 DaLEVON HALABELIAN
Group Leader. University of Toronto. l.halabelian@utoronto.ca. +1 416 9463876. Epigenetics. Ubiquitin Biology. Structural Biology. Levon holds a Diploma degree in pharmacy from the Yerevan state Medical University, Armenia, a MSc degree in Applied Biotechnology from Uppsala University, Sweden, and a PhD degree in Biomolecular Sciencesfrom the
TYPE II INHIBITORS TARGETING CDK2 1 Type II inhibitors targeting CDK2 Leila T. Alexander §,‡,†, ∥Henrik Möbitz , Peter Drueckes ∥, Pavel Savitsky §, Oleg Fedorov §⊥, Jonathan M. Elkins §⊥, Charlotte M. Deane ∥‡, Sandra W. Cowan-Jacob , and Stefan Knapp §&⊥* §Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Ox-ALEX N. BULLOCK
Alex Bullock trained at the University of Cambridge in biochemistry. His PhD research under the mentorship of Sir Alan Fersht characterised the folding and stability of mutant p53 and stimulated efforts to identify chemical chaperones that rescued mutant p53 activity incancer cells.
KILIAN HUBER
Dr. Kilian V. M. Huber received his doctorate in Medicinal and Pharmaceutical Chemistry from the Ludwig-Maximilians-Universität (LMU) in Munich working on the design and synthesis of natural product-inspired kinase inhibitors in the group Prof. Franz Bracher. SGC | STRUCTURAL GENOMICS CONSORTIUMNEWSCAREERSPUBLICATIONSCONTACTLOGINPLEASEAVOID
The SGC is a not-for-profit organization which accelerates research by making all its research output available to the scientific community with no strings attached, and by creating an open collaborative network of scientists in hundreds of universities around theSGC OXFORD | SGC
The SGC Oxford laboratories, under the direction of Prof. Chas Bountra, are housed within the University's Old Road Campus located in Headington, Oxford. SGC Oxford is part of the Nuffield Department of Clinical Medicine and scientists at SGC Oxford are affiliated with several University Departments including the Kennedy Institute and the| SGC
Overview. The normal development of our tissues, body shape and size is strictly coordinated. Secreted growth hormones and cytokines signal between cells to regulate the key physiological processes of growth and differentiation as well as responses to injury and infection. Inappropriate growth control is a defining feature of human cancer DONATED CHEMICAL PROBES Potent, selective and broadly characterized, small molecule chemical modulators of protein function (chemical probes) are powerful research reagents in both fundamental and applied biological research. In this unique project, several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have entered into a pre-competitiveDDR-TRK-1 | SGC
DDR-TRK-1 is a chemical probe for the DDR and TRK kinases with good in vitro and in vivo potency. DDR-TRK-1 inhibits colony formation and migration of Panc-1 pancreatic cancer cells. In cellular and mouse models of lung fibrosis, DDR-TRK-1 inhibits signaling, expression of fibrotic markers and fibrotic features such as hydroxprolineexpression.
LEVON HALABELIAN
Group Leader. University of Toronto. l.halabelian@utoronto.ca. +1 416 9463876. Epigenetics. Ubiquitin Biology. Structural Biology. Levon holds a Diploma degree in pharmacy from the Yerevan state Medical University, Armenia, a MSc degree in Applied Biotechnology from Uppsala University, Sweden, and a PhD degree in Biomolecular Sciencesfrom the
GSK484 | SGC
GSK484 A chemical probe for PAD-4 (Protein-arginine deiminase type-4) GSK484 is avaliable from Cayman Chemical and Sigma. For any inquiries please contact proberequests@thesgc.org. PAD4 is a calcium-dependent enzyme which catalyses the transformation of protein arginine residues into citrulline, with the release of ammonia. PAD4-dependentBILL ZUERCHER
william.zuercher@unc.edu. Chemical Probes. Bill Zuercher is Principal Investigator, Target Validation at the SGC-UNC and Research Associate Professor in the Division of Chemical Biology and Medicinal Chemistry in the UNC Eshelman School of Pharmacy. He is interested in using chemistry to elucidate biology, particularly through the designKILIAN HUBER
kilian.huber@sgc.ox.ac.uk. +44 1865 612875. Metabolic Enzymes & Complexes. Chemical Probes. Protein Kinases. Medicinal Chemistry. Screening Platforms. Dr. Kilian V. M. Huber received his doctorate in Medicinal and Pharmaceutical Chemistry from the Ludwig-Maximilians-Universität (LMU) in Munich working on the design and synthesis of natural VECTOR INFORMATION SHEET Vector information sheet Dated: 8th May 2013 Vector Name pFB-6HZB Source Pravin Mahajan Sequence accession/link Description Baculovirus transfer vector with His 6 SGC | STRUCTURAL GENOMICS CONSORTIUMNEWSCAREERSPUBLICATIONSCONTACTLOGINPLEASEAVOID
The SGC is a not-for-profit organization which accelerates research by making all its research output available to the scientific community with no strings attached, and by creating an open collaborative network of scientists in hundreds of universities around theSGC OXFORD | SGC
The SGC Oxford laboratories, under the direction of Prof. Chas Bountra, are housed within the University's Old Road Campus located in Headington, Oxford. SGC Oxford is part of the Nuffield Department of Clinical Medicine and scientists at SGC Oxford are affiliated with several University Departments including the Kennedy Institute and the| SGC
Overview. The normal development of our tissues, body shape and size is strictly coordinated. Secreted growth hormones and cytokines signal between cells to regulate the key physiological processes of growth and differentiation as well as responses to injury and infection. Inappropriate growth control is a defining feature of human cancer DONATED CHEMICAL PROBES Potent, selective and broadly characterized, small molecule chemical modulators of protein function (chemical probes) are powerful research reagents in both fundamental and applied biological research. In this unique project, several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have entered into a pre-competitiveDDR-TRK-1 | SGC
DDR-TRK-1 is a chemical probe for the DDR and TRK kinases with good in vitro and in vivo potency. DDR-TRK-1 inhibits colony formation and migration of Panc-1 pancreatic cancer cells. In cellular and mouse models of lung fibrosis, DDR-TRK-1 inhibits signaling, expression of fibrotic markers and fibrotic features such as hydroxprolineexpression.
LEVON HALABELIAN
Group Leader. University of Toronto. l.halabelian@utoronto.ca. +1 416 9463876. Epigenetics. Ubiquitin Biology. Structural Biology. Levon holds a Diploma degree in pharmacy from the Yerevan state Medical University, Armenia, a MSc degree in Applied Biotechnology from Uppsala University, Sweden, and a PhD degree in Biomolecular Sciencesfrom the
GSK484 | SGC
GSK484 A chemical probe for PAD-4 (Protein-arginine deiminase type-4) GSK484 is avaliable from Cayman Chemical and Sigma. For any inquiries please contact proberequests@thesgc.org. PAD4 is a calcium-dependent enzyme which catalyses the transformation of protein arginine residues into citrulline, with the release of ammonia. PAD4-dependentBILL ZUERCHER
william.zuercher@unc.edu. Chemical Probes. Bill Zuercher is Principal Investigator, Target Validation at the SGC-UNC and Research Associate Professor in the Division of Chemical Biology and Medicinal Chemistry in the UNC Eshelman School of Pharmacy. He is interested in using chemistry to elucidate biology, particularly through the designKILIAN HUBER
kilian.huber@sgc.ox.ac.uk. +44 1865 612875. Metabolic Enzymes & Complexes. Chemical Probes. Protein Kinases. Medicinal Chemistry. Screening Platforms. Dr. Kilian V. M. Huber received his doctorate in Medicinal and Pharmaceutical Chemistry from the Ludwig-Maximilians-Universität (LMU) in Munich working on the design and synthesis of natural VECTOR INFORMATION SHEET Vector information sheet Dated: 8th May 2013 Vector Name pFB-6HZB Source Pravin Mahajan Sequence accession/link Description Baculovirus transfer vector with His 6 THE VIRAL INTERRUPTION MEDICINES INITIATIVE (VIMI): OPEN In an opinion piece to Canada's The Hill Times, Drs Richard Gold, Tania Bubela, Aled Edwards and John Bamforth announced the creation of the Viral Interruption Medicines Initiative (VIMI). The partnership will leverage open science to develop anti-viral drugs in anticipation for future pandemics. Full article below and here. Canada needs a proactive pandemic innovation SDDC - STRUCTURE-GUIDED DRUG DISCOVERY COALITION Medicinal Chemistry projects are focussed on the best disease-validated targets only. Small-molecule drug-discovery, as typified by pharmaceutical industry practice, is an extremely high-risk, lengthy and expensive enterprise. The attrition rate from the starting of an early Discovery project to a launched drug is in the range of 95-99%, depending on indication. True validation of atarget
| SGC
Sebastian obtained his PhD at the Max Planck Research Unit for Enzymology of Protein Folding (Halle, Germany) working on peptidyl-prolyl cis/trans isomerases. He joined the SGC in 2012 to investigate kinases linked to Parkinson's disease. In doing so, he collaborates closely with Boehringer-Ingelheim. Fiona Sorrell graduated with a MastersSGC VECTORS
This table shows data for SGC vectors - click the Clone Vector ID for a PDF information sheet for the vector. Links to AddGene to purchase vectors are in the Description column. Links to AddGene and Source BioScience to purchase vectors are in the Description column Clone Vector ID GenBank Deposition ID SGC Site Description pBacMam2-SDiEx-LIC Toronto Baculovirus and mammalianSGC UNICAMP
SGC-UNICAMP Protein Kinase Chemical Biology Center - supporting drug development throught open-access research. The SGC-UNICAMP Center funded by FAPESP, UNICAMP and SGC, is focused on developing molecular probes for protein kinases regulating RNA splicing and chromatin, with strong links to the other SGC laboratories and our network of industrial funders and academic collaborators.QUICK FACTS
Name %Iden: Description: NP_775740. 100. ubiquitin-conjugating enzyme E2Q (putative) 2 XP_001145531. 99. PREDICTED: ubiquitin-conjugatingGSK484 | SGC
GSK484 A chemical probe for PAD-4 (Protein-arginine deiminase type-4) GSK484 is avaliable from Cayman Chemical and Sigma. For any inquiries please contact proberequests@thesgc.org. PAD4 is a calcium-dependent enzyme which catalyses the transformation of protein arginine residues into citrulline, with the release of ammonia. PAD4-dependentNVS-BPTF-1 | SGC
NVS-BPTF-C. BPTF (Bromodomain PHD-finer Transcription Factor, also known as FALZ) is a multi-domain protein containing multiple histone lysine recognition domains. BPTF binds to acetylated H3 and H4 histone tails via its Bromodomain and H3K4me3 via the second PHD domain (1). BPTF is part of the NURF chromatin remodelling complex and involved inKATLIN B. MASSIRER
Katlin B. Massirer is the Chief Operational Officer at SGC-Campinas, Principal Investigator and Head of the Laboratory on RNA Regulation and Disease at UNICAMP, Brazil. She obtained her PhD in molecular biology and bioinformatics at the University of California San Diego(UCSD).
KILIAN HUBER
Dr. Kilian V. M. Huber received his doctorate in Medicinal and Pharmaceutical Chemistry from the Ludwig-Maximilians-Universität (LMU) in Munich working on the design and synthesis of natural product-inspired kinase inhibitors in the group Prof. Franz Bracher. Skip to main content
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WELCOME TO SGC
THE SGC EMBARKS ON A NEW PROJECT AS PART OF THE EUBOPEN CONSORTIUM The consortium consists of 22 partners that will work together to develop high quality chemical tools12345
RAPIDLY EMERGING ANTIVIRAL DRUG DEVELOPMENT INITIATIVE (READDI) Open science drug discovery partnership, READDI, aims to invest $125 million to prevent future pandemics12345
NEW OPEN-AD DRUG DISCOVERY CENTER SGC and collaborators to create open research tools for Alzheimer’s disease research funded by National Institute on Aging12345
CHEMICAL PROBES AS ESSENTIAL TOOLS FOR BIOLOGICAL DISCOVERY A webinar moderated by Cell Press's MISHTU DEY and featuring talks by ANNA GREKA, DANIEL NOMURA and PAUL WORKMAN. This resource is a great starting point to learn about chemical probes and how best to usethem.
12345
DISCOVERY OF A CHEMICAL PROBE FOR PRDM9 A collaboration between MSD and the SGC has resulted in the discovery of MRK-740, a potent inhibitor of PRDM912345
LATEST STRUCTURES
WDR55: WD repeat-containing protein 55, WDR domain KIF21A: Human Kinesin-like protein KIF21A, WDR domain FEM1C: Human E3 ligase protein fem-1 homolog C, ankyrin repeat, in complex with peptide SCAF4: Human SR-related and CTD-associated factor 4, CID domain, in complex with peptide S2,S5p-CTD FEM1C: Human protein fem-1 homolog C, N-terminal ankyrin repeat WHSC1: Human histone-lysine N-methyltransferase NSD2, first PWWP domain, in complex with chemical probe UNC6934 GID4: Human Glucose-induced degradation protein 4, substrate binding domain, in complex VGLWKS peptideall structures
NEW PUBLICATIONS
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashionChemical Science
A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models. Neuropsychopharmacology Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.J Biol Chem
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease Nature Communications SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020Eurosurveillance
Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison The Lancet Infectious Diseases Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.Commun Biol
full list
CHEMICAL PROBES
NR162 - A chemical probe for CASK _1st September 2020_ PFI-6 - A novel chemical probe for MLLT1/3_23rd June 2020_
SGC-CK2-1 - A chemical probe for CK2_11th June 2020_
NVS-MLLT-1 - A Potent and Selective inhibitor of YEATS proteins_5th March 2020_
show all
NEWS FROM SGC
Cheryl Arrowsmith of SGC-Toronto elected a Fellow of the RoyalSociety of Canada
Posted on _10th September 2020_ Structure of LRRK2 in Parkinson’s disease and model for microtubuleinteraction
Posted on _1st September 2020_ The Viral Interruption Medicines Initiative (VIMI): Open Science coalition in Canada to prevent future pandemics Posted on _15th May 2020_more news
FOCUS ON...
Integral Membrane Proteins at SGC With the involvement of:* Liz Carpenter
Integral Membrane ProteinsSGC CAREERS
Open vacancies : 2
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SGC OXFORD
University of Oxford Old Road Campus Research BuildingRoosevelt Drive
Headington
Oxford OX3 7DQ
UK
+44 1865 617756
oxford@thesgc.org
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SGC TORONTO
Structural Genomics Consortium MaRS Centre, South Tower 101 College St., Suite 700 Toronto, ON, M5G 1L7Canada
+1 416-946-0237
toronto@thesgc.org
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SGC UNICAMP
Universidade Estadual de Campinas – Unicamp Cidade Universitária Zeferino Vaz Av. Dr. André Tosello, 550Barão Geraldo
Campinas/SP
CEP: 13083-886
+55 19 3521-5234
jon.elkins@sgc.ox.ac.ukDirections
SGC KAROLINSKA
Center for Molecular Medicine (CMM)L8:02
Karolinska University Hospital171 76 Stockholm
Sweden
michael.sundstrom@thesgc.orgSGC UNC
The University of North Carolina at Chapel Hill UNC Eshelman School of Pharmacy Division of Chemical Biology and Medicinal Chemistry 1070H Genetic Medicine Building120 Mason Farm Rd
Chapel Hill, NC 27599USA
+1 919-962-5349
sgc-unc@unc.edu
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SGC FRANKFURT
Goethe University Frankfurt Buchmann Institute for Life Sciences (BMLS)Riedberg Campus
Max-von-Laue-Str. 15 60438 Frankfurt am Main+49 69 798-29871
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