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DETECTR BOOST™ SARS-COV-2 DETECTR BOOST™ SARS-CoV-2 Kit*. A CRISPR-based detection platform for SARS-CoV-2. Mammoth Biosciences is developing a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform up to 1,500 tests per shift with minimal user interaction. OUR TEAM - MAMMOTH BIOSCIENCES With a distinguished team including co-founder and CRISPR-Cas genome editing co-inventor Jennifer Doudna, Mammoth is addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, and more. Team. Each person at Mammoth plays a vital role in building CRISPR-based tools spanning the intersection of data science and HOW SARS-COV-2 IMPACTS THE BODY The SARS-CoV-2 virus causes direct damage by killing cells. The immune system causes additional damage by killing infected cells and causing collateral damage to nearby cells. For many severe cases of COVD-19, the immune system can eventually overcome the virus — usually with the aid of physicians who slow the spread of the virus and tamp IMPORTANT FACTORS TO CONSIDER IN CRISPR DELIVERY THE IMPORTANCE OF POINT-OF-NEED DIAGNOSTICS FOR COVID-19SEE MORE ONMAMMOTH.BIO
A P R O TO C O L FO R R A P I D D E TE C TI O N O F TH E 2 A p r o to c o l fo r r a p i d d e te c ti o n o f th e 2 0 1 9 n o v e l c o r o n a v i r u s S A R S -C o V -2 u s i n g C R I S P R d i a g n o s ti c s : S A R CRISPR DIAGNOSTICS IN HEALTHCARE CRISPR diagnostics can detect bacteria, viruses, and mutations in human DNA. To do so, researchers simply guide the molecular scissors to DNA or RNA indicative of the bacteria, viruses, or mutations they’d like to detect. Benefits of CRISPR diagnostics. Customizability: CRISPR diagnostics can detect a wide range ofdiseases.
CRISPR DIAGNOSTICS IN CANCER TREATMENT CRISPR diagnostics can make it easier to treat patients following the principles of precision medicine. We can easily design CRISPR diagnostics to identify DNA sequences associated with particular types of cancer. Physicians can then use these diagnostics to test tumor samples from patients. THE CAS PROTEINS BEHIND CRISPR DIAGNOSTICS Cas14. The Cas14 proteins bind to and cut user-specified, single-stranded or double stranded DNA. To detect RNA, Cas14-based diagnostics must be combined with proteins that convert RNA into DNA. The Cas14 proteins are on the smaller end at 400 – 700 amino acids. They take fewer resources to create in the lab. MAMMOTH BIOSCIENCESBLOG INSIGHTS FROM OUR TEAMPUBLICATIONS LEARN MORE ABOUT OUR TECHNOLOGY Hi, we’re Mammoth. We are scientists, engineers, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. With a distinguished team including co-founder and CRISPR co-inventor Jennifer Doudna, we are addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, andmore.
DETECTR BOOST™ SARS-COV-2 DETECTR BOOST™ SARS-CoV-2 Kit*. A CRISPR-based detection platform for SARS-CoV-2. Mammoth Biosciences is developing a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform up to 1,500 tests per shift with minimal user interaction. OUR TEAM - MAMMOTH BIOSCIENCES With a distinguished team including co-founder and CRISPR-Cas genome editing co-inventor Jennifer Doudna, Mammoth is addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, and more. Team. Each person at Mammoth plays a vital role in building CRISPR-based tools spanning the intersection of data science and HOW SARS-COV-2 IMPACTS THE BODY The SARS-CoV-2 virus causes direct damage by killing cells. The immune system causes additional damage by killing infected cells and causing collateral damage to nearby cells. For many severe cases of COVD-19, the immune system can eventually overcome the virus — usually with the aid of physicians who slow the spread of the virus and tamp IMPORTANT FACTORS TO CONSIDER IN CRISPR DELIVERY THE IMPORTANCE OF POINT-OF-NEED DIAGNOSTICS FOR COVID-19SEE MORE ONMAMMOTH.BIO
A P R O TO C O L FO R R A P I D D E TE C TI O N O F TH E 2 A p r o to c o l fo r r a p i d d e te c ti o n o f th e 2 0 1 9 n o v e l c o r o n a v i r u s S A R S -C o V -2 u s i n g C R I S P R d i a g n o s ti c s : S A R CRISPR DIAGNOSTICS IN HEALTHCARE CRISPR diagnostics can detect bacteria, viruses, and mutations in human DNA. To do so, researchers simply guide the molecular scissors to DNA or RNA indicative of the bacteria, viruses, or mutations they’d like to detect. Benefits of CRISPR diagnostics. Customizability: CRISPR diagnostics can detect a wide range ofdiseases.
CRISPR DIAGNOSTICS IN CANCER TREATMENT CRISPR diagnostics can make it easier to treat patients following the principles of precision medicine. We can easily design CRISPR diagnostics to identify DNA sequences associated with particular types of cancer. Physicians can then use these diagnostics to test tumor samples from patients. THE CAS PROTEINS BEHIND CRISPR DIAGNOSTICS Cas14. The Cas14 proteins bind to and cut user-specified, single-stranded or double stranded DNA. To detect RNA, Cas14-based diagnostics must be combined with proteins that convert RNA into DNA. The Cas14 proteins are on the smaller end at 400 – 700 amino acids. They take fewer resources to create in the lab. DETECTR BOOST™ SARS-COV-2 DETECTR BOOST™ SARS-CoV-2 Kit*. A CRISPR-based detection platform for SARS-CoV-2. Mammoth Biosciences is developing a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform up to 1,500 tests per shift with minimal user interaction. ABOUT US - MAMMOTH BIOSCIENCES About Us. Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. With a distinguished team including co-founder and CRISPR-Cas genome editing coNEWSROOM ARCHIVE
Mammoth Biosciences Named to Fierce Medtech’s “Fierce 15” Companies of 2020 for Advancing Next Generation CRISPR Products in Diagnostics and Therapeutics. WebWire. Learn More. Press Releases. Mammoth Biosciences and Agilent Partner on High-Throughput CRISPR-Based SARS-CoV-2 Diagnostic Test. WebWire. Learn More. PressReleases.
DIAGNOSTICS
Diagnostics. The CRISPR-based detection platform. Our revolutionary method for molecular diagnostics, enabling limitless testing possibilities. Simple. Molecular-based diagnosis. Our CRISPR-powered diagnostics provide unambiguous results in an instrument-free and disposable format. Fast. Results within 20 minutes. BLOG - MAMMOTH BIOSCIENCES The COVID-19 pandemic rages on, but it’s important to remember that other infectious diseases continue to have huge global impacts. Indeed, COVID-19 may be making it more difficult to address other diseases (Eg. HIV/AIDs, other STIs, antibiotic resistant infections). In this “Infectious Disease Spotlight” series, we cover 3 of the most globally impactful infectious diseases. CAREERS - MAMMOTH BIOSCIENCES Careers. Passion meets purpose. We are a team of scientists, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. Our Values. We live and breathe them. Rigor. We lead with science and data. Diversity. Our Mammoth strength PARTNER - MAMMOTH BIOSCIENCES The Mammoth Vision. Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. With a distinguished team including co-founder and CRISPR-Cas genome editingCOVID-19 RESOURCES
02/25/2020. The COVID-19 outbreak has spurred many researchers and clinicians into action. The pace at which they’ve mobilized is inspiring. It has led to the publication of many news articles, think pieces, and research papers. Yet, these rapid developments can make it difficult to get a good grasp on everything that’s happening.GENOME EDITING
Genome Editing. Enhanced genome editing with an expanded CRISPR toolkit. Our CRISPR-Cas systems provide unprecedented power to edit the genome. Expanded Targeting. Edit more of the genome. With alternative and shorter PAM requirements, newly discovered nucleases can direct edits to an expanded set of DNA sequences. FlexibleDelivery.
EXPANDING THE POSSIBILITIES OF CRISPR GENOME EDITING WITH Genome editing is the process researchers use to make targeted changes to an organism’s DNA (its genome). Scientists have used a variety of technologies for genome editing (see the history of genome editing here). However, since ~2012, CRISPR has made the genome editing processes much easier. CRISPR associated or “Cas” proteins drivethis process.
MAMMOTH BIOSCIENCESBLOG INSIGHTS FROM OUR TEAMPUBLICATIONS LEARN MORE ABOUT OUR TECHNOLOGY Hi, we’re Mammoth. We are scientists, engineers, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. With a distinguished team including co-founder and CRISPR co-inventor Jennifer Doudna, we are addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, andmore.
DETECTR BOOST™ SARS-COV-2 DETECTR BOOST™ SARS-CoV-2 Kit*. A CRISPR-based detection platform for SARS-CoV-2. Mammoth Biosciences is developing a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform up to 1,500 tests per shift with minimal user interaction. OUR TEAM - MAMMOTH BIOSCIENCES With a distinguished team including co-founder and CRISPR-Cas genome editing co-inventor Jennifer Doudna, Mammoth is addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, and more. Team. Each person at Mammoth plays a vital role in building CRISPR-based tools spanning the intersection of data science and ABOUT US - MAMMOTH BIOSCIENCES About Us. Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. With a distinguished team including co-founder and CRISPR-Cas genome editing coDIAGNOSTICS
Diagnostics. The CRISPR-based detection platform. Our revolutionary method for molecular diagnostics, enabling limitless testing possibilities. Simple. Molecular-based diagnosis. Our CRISPR-powered diagnostics provide unambiguous results in an instrument-free and disposable format. Fast. Results within 20 minutes. HOW SARS-COV-2 IMPACTS THE BODY The SARS-CoV-2 virus causes direct damage by killing cells. The immune system causes additional damage by killing infected cells and causing collateral damage to nearby cells. For many severe cases of COVD-19, the immune system can eventually overcome the virus — usually with the aid of physicians who slow the spread of the virus and tampWHITE PAPER
Given the global health emergency, rapid transmission, and severe respiratory disease associated with the outbreak of the 2019 novel coronavirus (SARS-CoV-2), Mammoth Biosciences has reconfigured our DETECTR platform to rapidly and accurately detect SARS-CoV-2 using a visual lateral flow strip format within 30 minutes from sample toresult.
IMPORTANT FACTORS TO CONSIDER IN CRISPR DELIVERY A P R O TO C O L FO R R A P I D D E TE C TI O N O F TH E 2 A p r o to c o l fo r r a p i d d e te c ti o n o f th e 2 0 1 9 n o v e l c o r o n a v i r u s S A R S -C o V -2 u s i n g C R I S P R d i a g n o s ti c s : S A R THE CAS PROTEINS BEHIND CRISPR DIAGNOSTICS Cas14. The Cas14 proteins bind to and cut user-specified, single-stranded or double stranded DNA. To detect RNA, Cas14-based diagnostics must be combined with proteins that convert RNA into DNA. The Cas14 proteins are on the smaller end at 400 – 700 amino acids. They take fewer resources to create in the lab. MAMMOTH BIOSCIENCESBLOG INSIGHTS FROM OUR TEAMPUBLICATIONS LEARN MORE ABOUT OUR TECHNOLOGY Hi, we’re Mammoth. We are scientists, engineers, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. With a distinguished team including co-founder and CRISPR co-inventor Jennifer Doudna, we are addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, andmore.
DETECTR BOOST™ SARS-COV-2 DETECTR BOOST™ SARS-CoV-2 Kit*. A CRISPR-based detection platform for SARS-CoV-2. Mammoth Biosciences is developing a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform up to 1,500 tests per shift with minimal user interaction. OUR TEAM - MAMMOTH BIOSCIENCES With a distinguished team including co-founder and CRISPR-Cas genome editing co-inventor Jennifer Doudna, Mammoth is addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, and more. Team. Each person at Mammoth plays a vital role in building CRISPR-based tools spanning the intersection of data science and ABOUT US - MAMMOTH BIOSCIENCES About Us. Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. With a distinguished team including co-founder and CRISPR-Cas genome editing coDIAGNOSTICS
Diagnostics. The CRISPR-based detection platform. Our revolutionary method for molecular diagnostics, enabling limitless testing possibilities. Simple. Molecular-based diagnosis. Our CRISPR-powered diagnostics provide unambiguous results in an instrument-free and disposable format. Fast. Results within 20 minutes. HOW SARS-COV-2 IMPACTS THE BODY The SARS-CoV-2 virus causes direct damage by killing cells. The immune system causes additional damage by killing infected cells and causing collateral damage to nearby cells. For many severe cases of COVD-19, the immune system can eventually overcome the virus — usually with the aid of physicians who slow the spread of the virus and tampWHITE PAPER
Given the global health emergency, rapid transmission, and severe respiratory disease associated with the outbreak of the 2019 novel coronavirus (SARS-CoV-2), Mammoth Biosciences has reconfigured our DETECTR platform to rapidly and accurately detect SARS-CoV-2 using a visual lateral flow strip format within 30 minutes from sample toresult.
IMPORTANT FACTORS TO CONSIDER IN CRISPR DELIVERY A P R O TO C O L FO R R A P I D D E TE C TI O N O F TH E 2 A p r o to c o l fo r r a p i d d e te c ti o n o f th e 2 0 1 9 n o v e l c o r o n a v i r u s S A R S -C o V -2 u s i n g C R I S P R d i a g n o s ti c s : S A R THE CAS PROTEINS BEHIND CRISPR DIAGNOSTICS Cas14. The Cas14 proteins bind to and cut user-specified, single-stranded or double stranded DNA. To detect RNA, Cas14-based diagnostics must be combined with proteins that convert RNA into DNA. The Cas14 proteins are on the smaller end at 400 – 700 amino acids. They take fewer resources to create in the lab.DIAGNOSTICS
Diagnostics. The CRISPR-based detection platform. Our revolutionary method for molecular diagnostics, enabling limitless testing possibilities. Simple. Molecular-based diagnosis. Our CRISPR-powered diagnostics provide unambiguous results in an instrument-free and disposable format. Fast. Results within 20 minutes. HOW SARS-COV-2 IMPACTS THE BODY The SARS-CoV-2 virus causes direct damage by killing cells. The immune system causes additional damage by killing infected cells and causing collateral damage to nearby cells. For many severe cases of COVD-19, the immune system can eventually overcome the virus — usually with the aid of physicians who slow the spread of the virus and tamp A BROAD OVERVIEW OF CRISPR DELIVERY METHODS This is the second post in a two-part series on CRISPR delivery. In our previous post, we discussed some important factors to consider in CRISPR delivery. Here, we provide a broad overview of some popular CRISPR delivery methods. We break down delivery methods into physical/chemical methods and viral delivery methods. For morethorough reviews of
BLOG - MAMMOTH BIOSCIENCES The COVID-19 pandemic rages on, but it’s important to remember that other infectious diseases continue to have huge global impacts. Indeed, COVID-19 may be making it more difficult to address other diseases (Eg. HIV/AIDs, other STIs, antibiotic resistant infections). In this “Infectious Disease Spotlight” series, we cover 3 of the most globally impactful infectious diseases. CAREERS - MAMMOTH BIOSCIENCES Careers. Passion meets purpose. We are a team of scientists, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. Our Values. We live and breathe them. Rigor. We lead with science and data. Diversity. Our Mammoth strength TYPES OF COVID-19 TESTS The 3 main types of COVID-19 tests: nucleic acid, antigen, and serological. We can break down the 3 types of COVID-19 tests according to their use. Then, we can divide them further according to the compounds they actually detect. Nucleic acid and antigen tests are used to diagnose active infection. They look for components of theSARS-CoV-2
GENOME EDITING
Genome Editing. Enhanced genome editing with an expanded CRISPR toolkit. Our CRISPR-Cas systems provide unprecedented power to edit the genome. Expanded Targeting. Edit more of the genome. With alternative and shorter PAM requirements, newly discovered nucleases can direct edits to an expanded set of DNA sequences. FlexibleDelivery.
THE IMPORTANCE OF POINT-OF-NEED DIAGNOSTICS FOR COVID-19 Patients and healthcare workers can particularly benefit from Point-of-Need diagnostics when facing the challenges of infectious diseases like COVID-19. Because of it’s highly infectious nature, it is critical to rapidly diagnose COVID-19 to facilitate the necessary actions to prevent its spread. Healthcare workers can also act rapidlyto
CRISPR DIAGNOSTICS IN HEALTHCARE CRISPR diagnostics can detect bacteria, viruses, and mutations in human DNA. To do so, researchers simply guide the molecular scissors to DNA or RNA indicative of the bacteria, viruses, or mutations they’d like to detect. Benefits of CRISPR diagnostics. Customizability: CRISPR diagnostics can detect a wide range ofdiseases.
CRISPR DIAGNOSTICS IN CANCER TREATMENT CRISPR diagnostics can make it easier to treat patients following the principles of precision medicine. We can easily design CRISPR diagnostics to identify DNA sequences associated with particular types of cancer. Physicians can then use these diagnostics to test tumor samples from patients. MAMMOTH BIOSCIENCESBLOG INSIGHTS FROM OUR TEAMPUBLICATIONS LEARN MORE ABOUT OUR TECHNOLOGY Hi, we’re Mammoth. We are scientists, engineers, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. With a distinguished team including co-founder and CRISPR co-inventor Jennifer Doudna, we are addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, andmore.
DETECTR BOOST™ SARS-COV-2 DETECTR BOOST™ SARS-CoV-2 Kit*. A CRISPR-based detection platform for SARS-CoV-2. Mammoth Biosciences is developing a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform up to 1,500 tests per shift with minimal user interaction. OUR TEAM - MAMMOTH BIOSCIENCES With a distinguished team including co-founder and CRISPR-Cas genome editing co-inventor Jennifer Doudna, Mammoth is addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, and more. Team. Each person at Mammoth plays a vital role in building CRISPR-based tools spanning the intersection of data science and A BROAD OVERVIEW OF CRISPR DELIVERY METHODS This is the second post in a two-part series on CRISPR delivery. In our previous post, we discussed some important factors to consider in CRISPR delivery. Here, we provide a broad overview of some popular CRISPR delivery methods. We break down delivery methods into physical/chemical methods and viral delivery methods. For morethorough reviews of
ABOUT US - MAMMOTH BIOSCIENCES About Us. Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. With a distinguished team including co-founder and CRISPR-Cas genome editing coDIAGNOSTICS
Diagnostics. The CRISPR-based detection platform. Our revolutionary method for molecular diagnostics, enabling limitless testing possibilities. Simple. Molecular-based diagnosis. Our CRISPR-powered diagnostics provide unambiguous results in an instrument-free and disposable format. Fast. Results within 20 minutes.WHITE PAPER
Given the global health emergency, rapid transmission, and severe respiratory disease associated with the outbreak of the 2019 novel coronavirus (SARS-CoV-2), Mammoth Biosciences has reconfigured our DETECTR platform to rapidly and accurately detect SARS-CoV-2 using a visual lateral flow strip format within 30 minutes from sample toresult.
IMPORTANT FACTORS TO CONSIDER IN CRISPR DELIVERY A P R O TO C O L FO R R A P I D D E TE C TI O N O F TH E 2 A p r o to c o l fo r r a p i d d e te c ti o n o f th e 2 0 1 9 n o v e l c o r o n a v i r u s S A R S -C o V -2 u s i n g C R I S P R d i a g n o s ti c s : S A R THE CAS PROTEINS BEHIND CRISPR DIAGNOSTICS Cas14. The Cas14 proteins bind to and cut user-specified, single-stranded or double stranded DNA. To detect RNA, Cas14-based diagnostics must be combined with proteins that convert RNA into DNA. The Cas14 proteins are on the smaller end at 400 – 700 amino acids. They take fewer resources to create in the lab. MAMMOTH BIOSCIENCESBLOG INSIGHTS FROM OUR TEAMPUBLICATIONS LEARN MORE ABOUT OUR TECHNOLOGY Hi, we’re Mammoth. We are scientists, engineers, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. With a distinguished team including co-founder and CRISPR co-inventor Jennifer Doudna, we are addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, andmore.
DETECTR BOOST™ SARS-COV-2 DETECTR BOOST™ SARS-CoV-2 Kit*. A CRISPR-based detection platform for SARS-CoV-2. Mammoth Biosciences is developing a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform up to 1,500 tests per shift with minimal user interaction. OUR TEAM - MAMMOTH BIOSCIENCES With a distinguished team including co-founder and CRISPR-Cas genome editing co-inventor Jennifer Doudna, Mammoth is addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, and more. Team. Each person at Mammoth plays a vital role in building CRISPR-based tools spanning the intersection of data science and A BROAD OVERVIEW OF CRISPR DELIVERY METHODS This is the second post in a two-part series on CRISPR delivery. In our previous post, we discussed some important factors to consider in CRISPR delivery. Here, we provide a broad overview of some popular CRISPR delivery methods. We break down delivery methods into physical/chemical methods and viral delivery methods. For morethorough reviews of
ABOUT US - MAMMOTH BIOSCIENCES About Us. Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. With a distinguished team including co-founder and CRISPR-Cas genome editing coDIAGNOSTICS
Diagnostics. The CRISPR-based detection platform. Our revolutionary method for molecular diagnostics, enabling limitless testing possibilities. Simple. Molecular-based diagnosis. Our CRISPR-powered diagnostics provide unambiguous results in an instrument-free and disposable format. Fast. Results within 20 minutes.WHITE PAPER
Given the global health emergency, rapid transmission, and severe respiratory disease associated with the outbreak of the 2019 novel coronavirus (SARS-CoV-2), Mammoth Biosciences has reconfigured our DETECTR platform to rapidly and accurately detect SARS-CoV-2 using a visual lateral flow strip format within 30 minutes from sample toresult.
IMPORTANT FACTORS TO CONSIDER IN CRISPR DELIVERY A P R O TO C O L FO R R A P I D D E TE C TI O N O F TH E 2 A p r o to c o l fo r r a p i d d e te c ti o n o f th e 2 0 1 9 n o v e l c o r o n a v i r u s S A R S -C o V -2 u s i n g C R I S P R d i a g n o s ti c s : S A R THE CAS PROTEINS BEHIND CRISPR DIAGNOSTICS Cas14. The Cas14 proteins bind to and cut user-specified, single-stranded or double stranded DNA. To detect RNA, Cas14-based diagnostics must be combined with proteins that convert RNA into DNA. The Cas14 proteins are on the smaller end at 400 – 700 amino acids. They take fewer resources to create in the lab. A BROAD OVERVIEW OF CRISPR DELIVERY METHODS This is the second post in a two-part series on CRISPR delivery. In our previous post, we discussed some important factors to consider in CRISPR delivery. Here, we provide a broad overview of some popular CRISPR delivery methods. We break down delivery methods into physical/chemical methods and viral delivery methods. For morethorough reviews of
DIAGNOSTICS
Diagnostics. The CRISPR-based detection platform. Our revolutionary method for molecular diagnostics, enabling limitless testing possibilities. Simple. Molecular-based diagnosis. Our CRISPR-powered diagnostics provide unambiguous results in an instrument-free and disposable format. Fast. Results within 20 minutes. CAREERS - MAMMOTH BIOSCIENCES Careers. Passion meets purpose. We are a team of scientists, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. Our Values. We live and breathe them. Rigor. We lead with science and data. Diversity. Our Mammoth strength HOW SARS-COV-2 IMPACTS THE BODY The SARS-CoV-2 virus causes direct damage by killing cells. The immune system causes additional damage by killing infected cells and causing collateral damage to nearby cells. For many severe cases of COVD-19, the immune system can eventually overcome the virus — usually with the aid of physicians who slow the spread of the virus and tamp TYPES OF COVID-19 TESTS The 3 main types of COVID-19 tests: nucleic acid, antigen, and serological. We can break down the 3 types of COVID-19 tests according to their use. Then, we can divide them further according to the compounds they actually detect. Nucleic acid and antigen tests are used to diagnose active infection. They look for components of theSARS-CoV-2
GENOME EDITING
Genome Editing. Enhanced genome editing with an expanded CRISPR toolkit. Our CRISPR-Cas systems provide unprecedented power to edit the genome. Expanded Targeting. Edit more of the genome. With alternative and shorter PAM requirements, newly discovered nucleases can direct edits to an expanded set of DNA sequences. FlexibleDelivery.
THE IMPORTANCE OF POINT-OF-NEED DIAGNOSTICS FOR COVID-19 Patients and healthcare workers can particularly benefit from Point-of-Need diagnostics when facing the challenges of infectious diseases like COVID-19. Because of it’s highly infectious nature, it is critical to rapidly diagnose COVID-19 to facilitate the necessary actions to prevent its spread. Healthcare workers can also act rapidlyto
BUILDING CONSISTENT, RELIABLE TESTING CAPACITY WITH THE The vaccine effect on SARS-CoV-2 testing With the roll out of the first vaccinations, there is hope that things will begin to go back to normal. So what is the outlook for SARS-CoV-2 testing in 2021? Many testing labs are asking that question. While there is CRISPR DIAGNOSTICS IN HEALTHCARE CRISPR diagnostics can detect bacteria, viruses, and mutations in human DNA. To do so, researchers simply guide the molecular scissors to DNA or RNA indicative of the bacteria, viruses, or mutations they’d like to detect. Benefits of CRISPR diagnostics. Customizability: CRISPR diagnostics can detect a wide range ofdiseases.
CRISPR DIAGNOSTICS IN CANCER TREATMENT CRISPR diagnostics can make it easier to treat patients following the principles of precision medicine. We can easily design CRISPR diagnostics to identify DNA sequences associated with particular types of cancer. Physicians can then use these diagnostics to test tumor samples from patients. MAMMOTH BIOSCIENCESBLOG INSIGHTS FROM OUR TEAMPUBLICATIONS LEARN MORE ABOUT OUR TECHNOLOGY Hi, we’re Mammoth. We are scientists, engineers, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. With a distinguished team including co-founder and CRISPR co-inventor Jennifer Doudna, we are addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, andmore.
OUR TEAM - MAMMOTH BIOSCIENCES With a distinguished team including co-founder and CRISPR-Cas genome editing co-inventor Jennifer Doudna, Mammoth is addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, and more. Team. Each person at Mammoth plays a vital role in building CRISPR-based tools spanning the intersection of data science and ABOUT US - MAMMOTH BIOSCIENCES About Us. Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. With a distinguished team including co-founder and CRISPR-Cas genome editing co DETECTR BOOST™ SARS-COV-2 DETECTR BOOST™ SARS-CoV-2 Kit*. A CRISPR-based detection platform for SARS-CoV-2. Mammoth Biosciences is developing a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform up to 1,500 tests per shift with minimal user interaction.NEWSROOM ARCHIVE
Mammoth Biosciences Named to Fierce Medtech’s “Fierce 15” Companies of 2020 for Advancing Next Generation CRISPR Products in Diagnostics and Therapeutics. WebWire. Learn More. Press Releases. Mammoth Biosciences and Agilent Partner on High-Throughput CRISPR-Based SARS-CoV-2 Diagnostic Test. WebWire. Learn More. PressReleases.
CAREERS - MAMMOTH BIOSCIENCES Careers. Passion meets purpose. We are a team of scientists, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. Our Values. We live and breathe them. Rigor. We lead with science and data. Diversity. Our Mammoth strengthWHITE PAPER
Given the global health emergency, rapid transmission, and severe respiratory disease associated with the outbreak of the 2019 novel coronavirus (SARS-CoV-2), Mammoth Biosciences has reconfigured our DETECTR platform to rapidly and accurately detect SARS-CoV-2 using a visual lateral flow strip format within 30 minutes from sample toresult.
A P R O TO C O L FO R R A P I D D E TE C TI O N O F TH E 2 A p r o to c o l fo r r a p i d d e te c ti o n o f th e 2 0 1 9 n o v e l c o r o n a v i r u s S A R S -C o V -2 u s i n g C R I S P R d i a g n o s ti c s : S A R CRISPR DIAGNOSTICS IN CANCER TREATMENT CRISPR diagnostics can make it easier to treat patients following the principles of precision medicine. We can easily design CRISPR diagnostics to identify DNA sequences associated with particular types of cancer. Physicians can then use these diagnostics to test tumor samples from patients. THE CAS PROTEINS BEHIND CRISPR DIAGNOSTICS Cas14. The Cas14 proteins bind to and cut user-specified, single-stranded or double stranded DNA. To detect RNA, Cas14-based diagnostics must be combined with proteins that convert RNA into DNA. The Cas14 proteins are on the smaller end at 400 – 700 amino acids. They take fewer resources to create in the lab. MAMMOTH BIOSCIENCESBLOG INSIGHTS FROM OUR TEAMPUBLICATIONS LEARN MORE ABOUT OUR TECHNOLOGY Hi, we’re Mammoth. We are scientists, engineers, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. With a distinguished team including co-founder and CRISPR co-inventor Jennifer Doudna, we are addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, andmore.
OUR TEAM - MAMMOTH BIOSCIENCES With a distinguished team including co-founder and CRISPR-Cas genome editing co-inventor Jennifer Doudna, Mammoth is addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, and more. Team. Each person at Mammoth plays a vital role in building CRISPR-based tools spanning the intersection of data science and ABOUT US - MAMMOTH BIOSCIENCES About Us. Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. With a distinguished team including co-founder and CRISPR-Cas genome editing co DETECTR BOOST™ SARS-COV-2 DETECTR BOOST™ SARS-CoV-2 Kit*. A CRISPR-based detection platform for SARS-CoV-2. Mammoth Biosciences is developing a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform up to 1,500 tests per shift with minimal user interaction.NEWSROOM ARCHIVE
Mammoth Biosciences Named to Fierce Medtech’s “Fierce 15” Companies of 2020 for Advancing Next Generation CRISPR Products in Diagnostics and Therapeutics. WebWire. Learn More. Press Releases. Mammoth Biosciences and Agilent Partner on High-Throughput CRISPR-Based SARS-CoV-2 Diagnostic Test. WebWire. Learn More. PressReleases.
CAREERS - MAMMOTH BIOSCIENCES Careers. Passion meets purpose. We are a team of scientists, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. Our Values. We live and breathe them. Rigor. We lead with science and data. Diversity. Our Mammoth strengthWHITE PAPER
Given the global health emergency, rapid transmission, and severe respiratory disease associated with the outbreak of the 2019 novel coronavirus (SARS-CoV-2), Mammoth Biosciences has reconfigured our DETECTR platform to rapidly and accurately detect SARS-CoV-2 using a visual lateral flow strip format within 30 minutes from sample toresult.
A P R O TO C O L FO R R A P I D D E TE C TI O N O F TH E 2 A p r o to c o l fo r r a p i d d e te c ti o n o f th e 2 0 1 9 n o v e l c o r o n a v i r u s S A R S -C o V -2 u s i n g C R I S P R d i a g n o s ti c s : S A R CRISPR DIAGNOSTICS IN CANCER TREATMENT CRISPR diagnostics can make it easier to treat patients following the principles of precision medicine. We can easily design CRISPR diagnostics to identify DNA sequences associated with particular types of cancer. Physicians can then use these diagnostics to test tumor samples from patients. THE CAS PROTEINS BEHIND CRISPR DIAGNOSTICS Cas14. The Cas14 proteins bind to and cut user-specified, single-stranded or double stranded DNA. To detect RNA, Cas14-based diagnostics must be combined with proteins that convert RNA into DNA. The Cas14 proteins are on the smaller end at 400 – 700 amino acids. They take fewer resources to create in the lab. DETECTR BOOST™ SARS-COV-2 DETECTR BOOST™ SARS-CoV-2 Kit*. A CRISPR-based detection platform for SARS-CoV-2. Mammoth Biosciences is developing a turnkey workstation to run a CRISPR-based SARS-CoV-2 molecular assay based on automated liquid handling equipment. This high throughput system can perform up to 1,500 tests per shift with minimal user interaction.DIAGNOSTICS
Diagnostics. The CRISPR-based detection platform. Our revolutionary method for molecular diagnostics, enabling limitless testing possibilities. Simple. Molecular-based diagnosis. Our CRISPR-powered diagnostics provide unambiguous results in an instrument-free and disposable format. Fast. Results within 20 minutes. BLOG - MAMMOTH BIOSCIENCES The COVID-19 pandemic rages on, but it’s important to remember that other infectious diseases continue to have huge global impacts. Indeed, COVID-19 may be making it more difficult to address other diseases (Eg. HIV/AIDs, other STIs, antibiotic resistant infections). In this “Infectious Disease Spotlight” series, we cover 3 of the most globally impactful infectious diseases. PARTNER - MAMMOTH BIOSCIENCES The Mammoth Vision. Mammoth Biosciences is harnessing the diversity of nature to power the next generation of CRISPR products. Through its discovery of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. With a distinguished team including co-founder and CRISPR-Cas genome editingWHITE PAPER
Given the global health emergency, rapid transmission, and severe respiratory disease associated with the outbreak of the 2019 novel coronavirus (SARS-CoV-2), Mammoth Biosciences has reconfigured our DETECTR platform to rapidly and accurately detect SARS-CoV-2 using a visual lateral flow strip format within 30 minutes from sample toresult.
THE IMPORTANCE OF POINT-OF-NEED DIAGNOSTICS FOR COVID-19 Patients and healthcare workers can particularly benefit from Point-of-Need diagnostics when facing the challenges of infectious diseases like COVID-19. Because of it’s highly infectious nature, it is critical to rapidly diagnose COVID-19 to facilitate the necessary actions to prevent its spread. Healthcare workers can also act rapidlyto
IMPORTANT FACTORS TO CONSIDER IN CRISPR DELIVERY Immunogenicity is a very important factor to consider in in vivo therapies. Toxicity – Some delivery methods use chemicals or treat cells in ways that are toxic. These can result in cell death. Lower toxicity is generally better across all settings. Integration CRISPR DIAGNOSTICS IN THE FIGHT AGAINST INFECTIOUS DISEASE While other nucleic acid-based diagnostics might be difficult to deploy in these regions, CRISPR Dx should be useable directly at the point of care. Thus, CRISPR Dx will be a huge boon to health care providers in these regions. CRISPR Dx will help shore up THE MANY APPLICATIONS OF (CRISPR) GENOME EDITING Many of the tools in the ever-expanding CRISPR toolkit are lauded for their genome editing capabilities. That is, these tools make it easy for scientists to change specific DNA sequences in precise ways. Yet, what truly makes these tools exciting is their fascinatingapplications.
CRISPR DIAGNOSTICS IN HEALTHCARE CRISPR diagnostics can detect bacteria, viruses, and mutations in human DNA. To do so, researchers simply guide the molecular scissors to DNA or RNA indicative of the bacteria, viruses, or mutations they’d like to detect. Benefits of CRISPR diagnostics. Customizability: CRISPR diagnostics can detect a wide range ofdiseases.
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THE CRISPR-BASED DETECTION PLATFORM Our revolutionary method for molecular diagnostics, enabling limitless testing possibilities.Learn More
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ENHANCED GENOME EDITING WITH AN EXPANDED CRISPR TOOLKIT Our CRISPR-Cas systems provide unprecedented power to edit the genome.Learn More
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DISCOVERING NOVEL CRISPR SYSTEMS We are addressing the current challenges of CRISPR-Cas systems and expanding the scope of use by applying our proprietary discovery platform to identify novel Cas proteins.Learn More
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HI, WE’RE MAMMOTH. We are scientists, entrepreneurs, and dreamers who are building the platform for CRISPR applications of the future. With a distinguished team including co-founder and CRISPR co-inventor Jennifer Doudna, we are addressing challenges across healthcare, agriculture, environmental monitoring, biodefense, and more.Learn More
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MAMMOTH BIOSCIENCES ANNOUNCES PEER-REVIEWED VALIDATION OF ITS RAPID, CRISPR-BASED COVID-19 DIAGNOSTICLearn More
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CRISPR–CAS12-BASED DETECTION OF SARS-COV-2 Broughton JP, Deng X, Yu G. et al. Nat Biotechnology. 2020; doi:10.1038/s41587-020-0513-4 Learn More*
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MAMMOTH BIOSCIENCES RAISES $45 MILLION TO BUILD NEXT-GENERATION CRISPR PRODUCTS FOR THERAPEUTICS AND DIAGNOSTICSLearn More
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MASSIVELY PARALLEL KINETIC PROFILING OF NATURAL AND ENGINEERED CRISPRNUCLEASES.
Jones SK, Hawkins JA, Johnson NV, Jung C, Hu K, Rybarski JR, Chen JS, Doudna JA, Press WH, Finkelstein IJ. https://www.biorxiv.org/content/10.1101/696393v1. Learn More*
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BRIEF SUMMARIES OF INTERESTING SCIENCE – MAMMOTH DIGESTS If you follow Mammoth on Twitter (and you should!), you may have noticed that we create threads summarizing cool research papers a few times a week. We call these threads #MammothDigests. They cover the key findings in papers on topics such as CRISPR, precision medicine, diagnostics, cancer, agriculture, and microbiology. You can find a fewLearn More
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A BROAD-SPECTRUM INHIBITOR OF CRISPR-CAS9. Harrington LB, Doxzen KW, Ma E, et al. Cell. 2017;170(6):1224–1233.e15. doi:10.1016/j.cell.2017.07.037 Learn More* 1
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Mammoth Biosciences Announces Peer-Reviewed Validation Of Its Rapid, CRISPR-Based COVID-19 DiagnosticLearn More
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