Are you over 18 and want to see adult content?
More Annotations
![A complete backup of focussolution.tech](https://www.archivebay.com/archive5/images/85e15178-1f00-4cf0-9730-2d1fdb6586c0.png)
A complete backup of focussolution.tech
Are you over 18 and want to see adult content?
![A complete backup of cruisecashcards.com](https://www.archivebay.com/archive5/images/bd3f59dd-b91b-4694-84bb-857e0b634bd5.png)
A complete backup of cruisecashcards.com
Are you over 18 and want to see adult content?
![A complete backup of vonageforhome.com](https://www.archivebay.com/archive5/images/94fe025e-0051-4db0-8186-854837613e40.png)
A complete backup of vonageforhome.com
Are you over 18 and want to see adult content?
![A complete backup of pamelasalzman.com](https://www.archivebay.com/archive5/images/93e0d3cf-a729-48e0-a32e-b9d3f8563155.png)
A complete backup of pamelasalzman.com
Are you over 18 and want to see adult content?
Favourite Annotations
![A complete backup of https://balkanje.com/turske-serije/osveta-2014/](https://www.archivebay.com/archive6/images/73ed2024-3fc0-4c6c-b8e8-a1482c3543ad.png)
A complete backup of https://balkanje.com/turske-serije/osveta-2014/
Are you over 18 and want to see adult content?
![A complete backup of https://balkanje.com/moja-braca-epizoda-12/](https://www.archivebay.com/archive6/images/edc6a004-f57f-4f8b-9e15-5c0737eb8585.png)
A complete backup of https://balkanje.com/moja-braca-epizoda-12/
Are you over 18 and want to see adult content?
![A complete backup of https://balkanje.com/zakletva-epizoda-394/](https://www.archivebay.com/archive6/images/878a6355-ec1e-4e65-848a-40c24f107d54.png)
A complete backup of https://balkanje.com/zakletva-epizoda-394/
Are you over 18 and want to see adult content?
![A complete backup of https://balkanje.com/oluja-epizoda-2/](https://www.archivebay.com/archive6/images/22180332-f430-4a5b-956b-87ea35fedf19.png)
A complete backup of https://balkanje.com/oluja-epizoda-2/
Are you over 18 and want to see adult content?
![A complete backup of https://balkanje.com/ne-brini-za-mene-epizoda-114/](https://www.archivebay.com/archive6/images/0d26068d-55ca-44d8-bace-539d5a48f117.png)
A complete backup of https://balkanje.com/ne-brini-za-mene-epizoda-114/
Are you over 18 and want to see adult content?
![A complete backup of https://balkanje.com/iskupljenje-epizoda-25/](https://www.archivebay.com/archive6/images/d6da42a8-8915-4be3-8c1f-107bc91a6de5.png)
A complete backup of https://balkanje.com/iskupljenje-epizoda-25/
Are you over 18 and want to see adult content?
Text
medicine
POINT - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG MSLT-2 - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG MSLT-1 - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG ISCHEMIA - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG POET - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORGFIDELIO-DKD
Existing steroidal mineralocorocoid receptor (MR) antagonists (e.g. spironolactone and eplerenone) have been trialed for the prevention of CKD, but their use is limited by off-target effects (e.g. gynecomastia, dysmenorrhea, and erectile dysfunction). This was the first phase 3 trial showing that selective, non-steroidal MRantagonism reduces
EAST-AFNET 4
ACOSOG Z0011
Clinical Question. Among T1-2 breast cancer patients with a positive sentinel lymph node biopsy undergoing lumpectomy and whole-breast radiation, does axillary lymph node dissection improve survival or local control compared to nodal observation? OPTIC NEURITIS TREATMENT TRIAL WIKI JOURNAL CLUBCARDIOLOGYRECENT UPDATESSELECT-DTRAPSCOAPT Wiki Journal Club. Clinical question of the day. In critically ill patients with acute tubular necrosis, does more intensive renal replacement therapy decrease the risk of death at 60 days compared to conventional less-intensive renal replacement therapy? – ATN. Wiki Journal Club ( WJC) summarizes and reviews landmark studies acrossmedicine
POINT - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG MSLT-2 - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG MSLT-1 - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG ISCHEMIA - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG POET - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORGFIDELIO-DKD
Existing steroidal mineralocorocoid receptor (MR) antagonists (e.g. spironolactone and eplerenone) have been trialed for the prevention of CKD, but their use is limited by off-target effects (e.g. gynecomastia, dysmenorrhea, and erectile dysfunction). This was the first phase 3 trial showing that selective, non-steroidal MRantagonism reduces
EAST-AFNET 4
ACOSOG Z0011
Clinical Question. Among T1-2 breast cancer patients with a positive sentinel lymph node biopsy undergoing lumpectomy and whole-breast radiation, does axillary lymph node dissection improve survival or local control compared to nodal observation? OPTIC NEURITIS TREATMENT TRIAL APROCCHSS - WIKI JOURNAL CLUB Published in 2018, the Recombinant Human Activated Protein C and Low Dose of Hydrocortisone and Fludrocortisone in Adult Septic Shock (APROCCHSS) study studied over 1,200 patients with septic shock admitted to the ICU. Patients were randomized in a 2×2 factorial design to activated protein C (APC; drotrecogin alfa) or placebo, or SEPSISPAM - WIKI JOURNAL CLUB The 2014 Sepsis and Mean Arterial Pressure (SEPSISPAM) trial randomized 776 patients with septic shock to a goal MAP of 65-70 or 80-85 mmHg for up to 5 days through vasopressor administration. (Both groups' average achieved MAPs were about 5 mmHg above the target range after day 2.) There was no difference between the two groups forall-cause
REWIND - WIKI JOURNAL CLUB Design. Multicenter, double-blind, randomized, controlled trial. Superiority trial. Primary efficacy outcome: time to first occurrence of vascular death, non-fatal myocardial infarction or non-fatal stroke. Determined that 9600 patients and 1200 primary outcomes were required to achieve 90% power (alpha = 0.05) All efficacy and safetyanalysis
A-HEFT - WIKI JOURNAL CLUB The 2004 African-American Heart Failure (A-HeFT) trial sought to study the hypothesis that ISDN/hydralazine would provide a survival benefit in a prospective, randomized trial of self-identified blacks with HFrEF. A-HeFT was terminated early when it demonstrated that ISDN/hydralazine was associated with a nearly 40% reduction inall-cause
WOSCOPS - WIKI JOURNAL CLUB The West of Scotland Coronary Prevention Study (WOSCOPS) was the first trial to demonstrate a significant reduction in CV events with statin therapy for primary prevention. WOSCOPS randomized 6595 middle-aged men with hyperlipidemia and no previous history of MI to pravastatin or placebo. This trial demonstrated a 31% relative risk reduction of BICAR-ICU - WIKI JOURNAL CLUB Bicarbonate 4.2% sodium bicarbonate intravenously with aim of goal arterial pH of ≥7.30 during 28-day ICU admission or ICU discharge; recommended infusion at 125-250 mL in 30 min, with max 1L in 24 hours after inclusion. Randomization was stratified by study site, age with cutoff of 65 years, presence of suspected sepsis, and presence of AKIN DAPA-CKD - WIKI JOURNAL CLUB There was a slightly higher risk of major hypoglycemia (0.7% vs. 1.3%; P=0.04; NNH=166) with dapagliflozin use. Overall, DAPA-CKD provides a new potential intervention for prevention of CKD progression among adults with CKD and at least some microalbuminuria (at least KDIGO CKD stage G2A2 severity). It might also reduce mortality in this MERIT-HF - WIKI JOURNAL CLUB The role of beta blockers in mortality reduction was unclear. The 1999 Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF) randomized 3,991 patients with symptomatic HF with EF ≤40% to metoprolol XL or placebo. The study was stopped early after an interim analysis demonstrated a 34% reduction in all-cause OPTIC NEURITIS TREATMENT TRIAL Acute treatment options: high dose corticosteroids (e.g., intravenous methylprednisolone) or no treatment depending upon individual risk-benefit ratio. Optic Neuritis Treatment Trial protocol: methylprednisolone 250 mg iv q 6 hours x 3 days, then prednisone 1 mg/kg/day po qd x 11 days, then 20 mg po on day 15 and 10 mg on days16 and 18 then
DECREASE-IV
Major Points. Bisoprolol initiated at a median 34 days before surgery, titrated to a perioperative heart rate of 50-70 beats per minute resulted in a reduction in perioperative cardiac death and nonfatal MIs. However, the DECREASE trials have been questioned and discredited due to falsified information and misconduct. WIKI JOURNAL CLUBCARDIOLOGYRECENT UPDATESSELECT-DTRAPSCOAPT Wiki Journal Club. Clinical question of the day. In critically ill patients with acute tubular necrosis, does more intensive renal replacement therapy decrease the risk of death at 60 days compared to conventional less-intensive renal replacement therapy? – ATN. Wiki Journal Club ( WJC) summarizes and reviews landmark studies acrossmedicine
POINT - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG MSLT-2 - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG MSLT-1 - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG ISCHEMIA - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG POET - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORGFIDELIO-DKD
Existing steroidal mineralocorocoid receptor (MR) antagonists (e.g. spironolactone and eplerenone) have been trialed for the prevention of CKD, but their use is limited by off-target effects (e.g. gynecomastia, dysmenorrhea, and erectile dysfunction). This was the first phase 3 trial showing that selective, non-steroidal MRantagonism reduces
EAST-AFNET 4
ACOSOG Z0011
Clinical Question. Among T1-2 breast cancer patients with a positive sentinel lymph node biopsy undergoing lumpectomy and whole-breast radiation, does axillary lymph node dissection improve survival or local control compared to nodal observation? OPTIC NEURITIS TREATMENT TRIAL WIKI JOURNAL CLUBCARDIOLOGYRECENT UPDATESSELECT-DTRAPSCOAPT Wiki Journal Club. Clinical question of the day. In critically ill patients with acute tubular necrosis, does more intensive renal replacement therapy decrease the risk of death at 60 days compared to conventional less-intensive renal replacement therapy? – ATN. Wiki Journal Club ( WJC) summarizes and reviews landmark studies acrossmedicine
POINT - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG MSLT-2 - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG MSLT-1 - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG ISCHEMIA - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORG POET - WIKI JOURNAL CLUBSEE MORE ON WIKIJOURNALCLUB.ORGFIDELIO-DKD
Existing steroidal mineralocorocoid receptor (MR) antagonists (e.g. spironolactone and eplerenone) have been trialed for the prevention of CKD, but their use is limited by off-target effects (e.g. gynecomastia, dysmenorrhea, and erectile dysfunction). This was the first phase 3 trial showing that selective, non-steroidal MRantagonism reduces
EAST-AFNET 4
ACOSOG Z0011
Clinical Question. Among T1-2 breast cancer patients with a positive sentinel lymph node biopsy undergoing lumpectomy and whole-breast radiation, does axillary lymph node dissection improve survival or local control compared to nodal observation? OPTIC NEURITIS TREATMENT TRIAL APROCCHSS - WIKI JOURNAL CLUB Published in 2018, the Recombinant Human Activated Protein C and Low Dose of Hydrocortisone and Fludrocortisone in Adult Septic Shock (APROCCHSS) study studied over 1,200 patients with septic shock admitted to the ICU. Patients were randomized in a 2×2 factorial design to activated protein C (APC; drotrecogin alfa) or placebo, or SEPSISPAM - WIKI JOURNAL CLUB The 2014 Sepsis and Mean Arterial Pressure (SEPSISPAM) trial randomized 776 patients with septic shock to a goal MAP of 65-70 or 80-85 mmHg for up to 5 days through vasopressor administration. (Both groups' average achieved MAPs were about 5 mmHg above the target range after day 2.) There was no difference between the two groups forall-cause
REWIND - WIKI JOURNAL CLUB Design. Multicenter, double-blind, randomized, controlled trial. Superiority trial. Primary efficacy outcome: time to first occurrence of vascular death, non-fatal myocardial infarction or non-fatal stroke. Determined that 9600 patients and 1200 primary outcomes were required to achieve 90% power (alpha = 0.05) All efficacy and safetyanalysis
A-HEFT - WIKI JOURNAL CLUB The 2004 African-American Heart Failure (A-HeFT) trial sought to study the hypothesis that ISDN/hydralazine would provide a survival benefit in a prospective, randomized trial of self-identified blacks with HFrEF. A-HeFT was terminated early when it demonstrated that ISDN/hydralazine was associated with a nearly 40% reduction inall-cause
WOSCOPS - WIKI JOURNAL CLUB The West of Scotland Coronary Prevention Study (WOSCOPS) was the first trial to demonstrate a significant reduction in CV events with statin therapy for primary prevention. WOSCOPS randomized 6595 middle-aged men with hyperlipidemia and no previous history of MI to pravastatin or placebo. This trial demonstrated a 31% relative risk reduction of BICAR-ICU - WIKI JOURNAL CLUB Bicarbonate 4.2% sodium bicarbonate intravenously with aim of goal arterial pH of ≥7.30 during 28-day ICU admission or ICU discharge; recommended infusion at 125-250 mL in 30 min, with max 1L in 24 hours after inclusion. Randomization was stratified by study site, age with cutoff of 65 years, presence of suspected sepsis, and presence of AKIN DAPA-CKD - WIKI JOURNAL CLUB There was a slightly higher risk of major hypoglycemia (0.7% vs. 1.3%; P=0.04; NNH=166) with dapagliflozin use. Overall, DAPA-CKD provides a new potential intervention for prevention of CKD progression among adults with CKD and at least some microalbuminuria (at least KDIGO CKD stage G2A2 severity). It might also reduce mortality in this MERIT-HF - WIKI JOURNAL CLUB The role of beta blockers in mortality reduction was unclear. The 1999 Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF) randomized 3,991 patients with symptomatic HF with EF ≤40% to metoprolol XL or placebo. The study was stopped early after an interim analysis demonstrated a 34% reduction in all-cause OPTIC NEURITIS TREATMENT TRIAL Acute treatment options: high dose corticosteroids (e.g., intravenous methylprednisolone) or no treatment depending upon individual risk-benefit ratio. Optic Neuritis Treatment Trial protocol: methylprednisolone 250 mg iv q 6 hours x 3 days, then prednisone 1 mg/kg/day po qd x 11 days, then 20 mg po on day 15 and 10 mg on days16 and 18 then
DECREASE-IV
Major Points. Bisoprolol initiated at a median 34 days before surgery, titrated to a perioperative heart rate of 50-70 beats per minute resulted in a reduction in perioperative cardiac death and nonfatal MIs. However, the DECREASE trials have been questioned and discredited due to falsified information and misconduct.MAIN PAGE
From Wiki Journal Club Jump to: navigation, searchWIKI JOURNAL CLUB
Clinical question of the day Among patients with submassive PE being treated with unfractionated heparin, does administration of tenecteplase reduce all-cause mortality or hemodynamic decompensation at 7 days when compared toplacebo?
– PEITHO
WIKI JOURNAL CLUB (WJC) summarizes and reviews landmark studies across medicine and surgical specialties. (MORE...)
BROWSE
Like our internal medicine reviews? Get the Journal Club: Medicine app for your mobile device.PUBLISHED ARTICLES
Allergy and ImmunologyCardiology
Critical Care
Dermatology
Emergency Medicine
Endocrinology
Gastroenterology
Gynecology
Hematology
Infectious Disease
Nephrology
Neurology
Obstetrics
Oncology
Ophthalmology
Pain Medicine
Palliative Care
Pediatrics
Physical Medicine and RehabilitationPreventive Medicine
Psychiatry
Pulmonology
Radiation Oncology
Radiology
Rheumatology
Surgery
Urology
* Recent Updates Reviews added mostrecently.
CONTRIBUTE
* Your first article A brief introduction for new WJC users. * Editorial staff Learn about editorial positions within Wiki Journal Club. * High-priority articles Start on these first! * Articles in review Under review for usability, but still need some TLC. * Incomplete articles The foundation has been laid, but they still need more work.Retrieved from
"http://www.wikijournalclub.org/w/index.php?title=Main_Page&oldid=33768"NAVIGATION MENU
PERSONAL TOOLS
* Create account
* Log in
NAMESPACES
* Main page
* Discussion
VARIANTS
VIEWS
* Read
* View source
* View history
MORE
SEARCH
NAVIGATION
* Main page
* Usable articles
* Recent changes
* Random page
* About
TOOLS
* What links here
* Related changes
* Special pages
* Printable version
* Permanent link
* Page information
* This page was last edited on 22 February 2019, at 05:56.* Privacy policy
* About Wiki Journal Club* Disclaimers
* Mobile view
*
Details
Copyright © 2024 ArchiveBay.com. All rights reserved. Terms of Use | Privacy Policy | DMCA | 2021 | Feedback | Advertising | RSS 2.0