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I., Grangeasse C.
NUCA - NUCLEASE PRECURSOR - SERRATIA MARCESCENS - NUCA Catalyzes the hydrolysis of both DNA and RNA, double- or single-stranded, at the 3'position of the phosphodiester bond to produce 5'-phosphorylated mono-, di-, tri- and tetranucleotides. DNA is a slightly better substrate than RNA. KMT2A - HISTONE-LYSINE N-METHYLTRANSFERASE 2A - HOMO Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic UNIPROTPEPTIDE SEARCHALIGNBLASTPANCREATIC ALPHA-AMYLASE PRECURSOR Align two or more protein sequences using the Clustal Omega program. Retrieve/ID mapping. Batch search with UniProt IDs or convert them to another type of database ID (or vice versa) Peptide search. Find sequences that exactly match a query peptide sequence. H - HEMAGGLUTININ GLYCOPROTEIN - MEASLES VIRUS (STRAIN Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface CLDN18 - CLAUDIN-18 - HOMO SAPIENS (HUMAN) - CLDN18 GENE CLDN18. 146. Annotation score: Annotation score:2 out of 5. The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score cannot be used as a measure of the accuracy of the annotation as we cannot define the GSDME - GASDERMIN-E - MUS MUSCULUS (MOUSE) - GSDME GENE Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis. This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis. CRY1AB - PESTICIDAL CRYSTAL PROTEIN CRY1AB - BACILLUS hide 10 20 30 40 50 mdnnpninec ipynclsnpe vevlggerie tgytpidisl sltqfllsef 60 70 80 90 100 vpgagfvlgl vdiiwgifgp sqwdaflvqi eqlinqriee farnqaisrl 110 120 130 140 150 eglsnlyqiy aesfrewead ptnpalreem riqfndmnsa lttaiplfav 160 170 180 190 200 qnyqvpllsv yvqaanlhls vlrdvsvfgq rwgfdaatin sryndltrli 210 220 230 240 250 gnytdhavrw yntglervwg pdsrdwiryn qfrreltltv ldivslfpny 260 270 280 290 300 IGHG1 - IMMUNOGLOBULIN HEAVY CONSTANT GAMMA 1 - HOMO Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into CLPP - ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates (PubMed UGD - UDP-GLUCOSE 6-DEHYDROGENASE - ESCHERICHIA COLI colanic acid biosynthetic process Source: EcoCyc. Inferred from direct assay i. "Tyrosine phosphorylation of the UDP-glucose dehydrogenase of Escherichia coli is at the crossroads of colanic acid synthesis and polymyxin resistance." Lacour S., Bechet E., Cozzone A.J., MijakovicI., Grangeasse C.
NUCA - NUCLEASE PRECURSOR - SERRATIA MARCESCENS - NUCA Catalyzes the hydrolysis of both DNA and RNA, double- or single-stranded, at the 3'position of the phosphodiester bond to produce 5'-phosphorylated mono-, di-, tri- and tetranucleotides. DNA is a slightly better substrate than RNA. KMT2A - HISTONE-LYSINE N-METHYLTRANSFERASE 2A - HOMO Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigeneticKEYWORDS - UNIPROT
Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest. Keywords are classified in 10 categories: An entry often contains several keywords. Inside a category, the keywords are stored in alphabetical order. Keywords can be used to retrieve subsets of protein entries or to generate indexesof
CI - REPRESSOR PROTEIN CI - ESCHERICHIA PHAGE LAMBDA - CI Acts as a transcriptional repressor that allows virus to establish and maintain latency. Prevents both the viral DNA replication and the exit programs. Clamps the two operator OL (operator left made of OL1, OL2 and OL3 sites) and OR (operator right made of OR1, OR2 and OR3 sites) together by binding to them and arranging the intervening DNA in aloop.
HSPG2 - BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular FCGR1A - HIGH AFFINITY IMMUNOGLOBULIN GAMMA FC RECEPTOR I hide 10 20 30 40 50 mwflttlllw vpvdgqvdtt kavitlqppw vsvfqeetvt lhcevlhlpg 60 70 80 90 100 ssstqwflng tatqtstpsy ritsasvnds geyrcqrgls grsdpiqlei 110 120 130 140 150 hrgwlllqvs srvftegepl alrchawkdk lvynvlyyrn gkafkffhwn 160 170 180 190 200 snltilktni shngtyhcsg mgkhrytsag isvtvkelfp apvlnasvts 210 220 230 240 250 pllegnlvtl scetklllqr pglqlyfsfy mgsktlrgrn tsseyqilta 260 270 280 290WWW.UNIPROT.ORG
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SAHH1 - ADENOSYLHOMOCYSTEINASE 1 - ARABIDOPSIS THALIANA Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Required for DNA methylation-dependent genesilencing.
RPON - RNA POLYMERASE SIGMA-54 FACTOR - ESCHERICHIA COLI Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of enzymes involved in arginine catabolism. The open complex (sigma-54 and core RNA polymerase) serves as the receptor for the receipt of the melting signal from the remotely bound activator protein GlnG(NtrC). GDF11 - GROWTH/DIFFERENTIATION FACTOR 11 PRECURSOR - HOMO Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the PHOA - ALKALINE PHOSPHATASE PRECURSOR - ESCHERICHIA COLI Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS). oxidoreductase activity, acting on phosphorus or arsenic in donors Source: EcoliWiki. Inferred from direct assay i. "A new activity for an old enzyme: Escherichia coli bacterial alkaline phosphatase is a phosphite-dependent hydrogenase." Yang SOLANUM LYCOPERSICUM (TOMATO) (LYCOPERSICON ESCULENTUM) Lycopersicon. Choose one > Solanum lycopersicum var. cerasiforme. All lower taxonomy nodes (1) Common name i. Tomato. Synonym i. Lycopersicon esculentum. OtherAn evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc.
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