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RxFiles. RxFiles Academic Detailing is a Canadian drug information resource. Our website is built to help answer your drug therapy questions through objective comparisons. We pursue a balanced, independent approach. We do NOT receive funding from the pharmaceutical industry. RXFILES | LOGINSIGN UPRXFILES APPS Switch to Desktop Version. Your IP Address Is 157.55.39.53 RXFILES DRUG COMPARISON CHARTS rxfiles.ca/charts. The 12th collected edition of our objective & comparative drug charts. Table of Contents Indices Full ReferenceList.
THIS HANDOUT IS IN GENERAL TYPE 2 DIABETES AND SICK DAYS I will increase the number of times I RECORD (check) my blood glucose levels when I am sick. If they are too high or too low, I will contact my health care provider. When you are sick, it is easy to become dehydrated from throwing up, diarrhea, and/or a fever. ANTICHOLINERGICS: REFERENCE LIST Drugs with Anticholinergic Effects . 5, 6, 7, 8. Diseases associated with an essential cholinergic deficit include Alzheimer’s dementia, Lewy body dementia & to IS APIXABAN (ELIQUIS®) AN OPTION FOR YOUR PATIENT CLOT Page 1 of 2 Collaborative Learning on Thrombosis (CLOT) – Canadian Prairie pharmacists with an interest in thromboembolic disorders This is intended only as a general reference to supplement existing knowledge of healthcare professionals in Canada & is not a substitute for sound clinical BUPRENORPHINE/NALOXONE SUBOXONE GUIDE DOSAGE … BUPRENORPHINE/NALOXONE SUBOXONE GUIDE DOSAGE FORMS DOSING: INDUCTION (methods for initiating someone) Generic: 2mg/0.5mg, 8mg/2mg Brand: 2mg/0.5mg, 8mg/ 2mg, 12mg/3mg, 16mg/4mg (need to order; not often stocked) Can be split/ crushed to ease dosing ANTIBIOTICS & COMMON INFECTIONS Antibiotics & Common Infections ABX-2: Uncomplicated Cystitis & Skin Stewardship, Effectiveness, Safety & Clinical Pearls- April 2017 ABX-2RELATED LINKS
OPIOID PATCH EXCHANGE DISPOSAL TOOL E.G. FENTANYL Opioid Patch Exchange Disposal Tool E.g. Fentanyl DURAGESIC patch, Buprenorphine BUTRANS patch Affix used patch to this sheet once removed from skin 2 Affix used patch to sheet once removed STOPPING YOUR PROTON PUMP INHIBITOR OR “PPI” This handout has been adapted by RxFiles, with permission, from The Vermont Academic Detailing Program (www.vtad.org) with consideration for Deprescribing Guidelines for the RXFILESOUR RESOURCESSTORESIGN UPCONTACT USPATIENT EDUCATIONPASSWORDRECOVERY
RxFiles. RxFiles Academic Detailing is a Canadian drug information resource. Our website is built to help answer your drug therapy questions through objective comparisons. We pursue a balanced, independent approach. We do NOT receive funding from the pharmaceutical industry. RXFILES | LOGINSIGN UPRXFILES APPS Switch to Desktop Version. Your IP Address Is 157.55.39.53 RXFILES DRUG COMPARISON CHARTS rxfiles.ca/charts. The 12th collected edition of our objective & comparative drug charts. Table of Contents Indices Full ReferenceList.
THIS HANDOUT IS IN GENERAL TYPE 2 DIABETES AND SICK DAYS I will increase the number of times I RECORD (check) my blood glucose levels when I am sick. If they are too high or too low, I will contact my health care provider. When you are sick, it is easy to become dehydrated from throwing up, diarrhea, and/or a fever. ANTICHOLINERGICS: REFERENCE LIST Drugs with Anticholinergic Effects . 5, 6, 7, 8. Diseases associated with an essential cholinergic deficit include Alzheimer’s dementia, Lewy body dementia & to IS APIXABAN (ELIQUIS®) AN OPTION FOR YOUR PATIENT CLOT Page 1 of 2 Collaborative Learning on Thrombosis (CLOT) – Canadian Prairie pharmacists with an interest in thromboembolic disorders This is intended only as a general reference to supplement existing knowledge of healthcare professionals in Canada & is not a substitute for sound clinical BUPRENORPHINE/NALOXONE SUBOXONE GUIDE DOSAGE … BUPRENORPHINE/NALOXONE SUBOXONE GUIDE DOSAGE FORMS DOSING: INDUCTION (methods for initiating someone) Generic: 2mg/0.5mg, 8mg/2mg Brand: 2mg/0.5mg, 8mg/ 2mg, 12mg/3mg, 16mg/4mg (need to order; not often stocked) Can be split/ crushed to ease dosing ANTIBIOTICS & COMMON INFECTIONS Antibiotics & Common Infections ABX-2: Uncomplicated Cystitis & Skin Stewardship, Effectiveness, Safety & Clinical Pearls- April 2017 ABX-2RELATED LINKS
OPIOID PATCH EXCHANGE DISPOSAL TOOL E.G. FENTANYL Opioid Patch Exchange Disposal Tool E.g. Fentanyl DURAGESIC patch, Buprenorphine BUTRANS patch Affix used patch to this sheet once removed from skin 2 Affix used patch to sheet once removed STOPPING YOUR PROTON PUMP INHIBITOR OR “PPI” This handout has been adapted by RxFiles, with permission, from The Vermont Academic Detailing Program (www.vtad.org) with consideration for Deprescribing Guidelines for theRXFILES PAIN BOOK
Managing acute-on-chronic-opioid pain is challenging; this chart offers tips for managing acute pain for patients already on codeine, fentanyl, heroin, hydromorphone, morphine, oxycodone, tapentadol, tramadol, methadone, or buprenorphine. RXFILES DRUG COMPARISON CHARTS rxfiles.ca/charts. The 12th collected edition of our objective & comparative drug charts. Table of Contents Indices Full ReferenceList.
RX FILES: Q&A SUMMARY Rx Files: Q&A Summary www.RxFiles.ca - Updated May 2021 Originally prepared by: M Jin, PharmD Non-Live Recombinant Herpes Zoster Vaccine (SHINGRIX) l What is SHINGRIX?1,2,3,4,5,6,7,8 Herpes Zoster (shingles) vaccine contains NON-live, recombinant, AS01B adjuvanted herpes zoster vaccine. This vaccine contains antigenANTIDEPRESSANTS
Antidepressants The Old and The New October, 1998 iii In 1958 researchers discovered that imipramine had antidepressant activity.1 Since then, a number of antidepressants have been developed with a variety of pharmacological mechanisms and side ONYCHOMYCOSIS TREATMENT Select drug interactions with antifungals 20 • Terbinafine has minimal significant drug interactions and is a good antifungal option for patients on multiple drug regimens. PARKINSON'S TREATMENT PARKINSON'S DISEASE (PD) – Drug Comparison Chart 1,2,3,4,5,6 Brent Jensen BSP - www.RxFiles.ca June 05 Generic/TRADE (Strength & forms)Class/Mechanism of Action/ Pregnancy category 7 Side effects / Contraindications CI = Therapeutic Use / Comments / Drug Interactions DI INITIAL & MAX DOSEDEMENTIA - RXFILES
DEMENTIA BRINGING EVIDENCE & EXPERIENCE TO DRUG THERAPY DECISION POINTS October 2014 INSIDE Pg 3: Cholinesterase Inhibitors (ChEI) in Dementia Pg 7: Geri‐RxFiles ‐ Dementia & Cognitive Impairment Pg 12: Geri‐RxFiles – Anticholinergics Reference List Pg 13: Geri‐RxFiles – Dementia: APPROACHES FOR STOPPING OR DOSE REDUCTION OF PPIS IN THOSE Table 2: Proton Pump Inhibitors (PPIs): Efficacy * Systematic Reviews: Common PPI Primary Care Indications Evidence for Gastrointestinal Outcomes Clinical Implications Uninvestigated gastroesophageal reflux disease (GERD) 16 Heartburn remission: PPI 72% vs. placebo 25%, NNT 2 high QOE PPI 55% vs. H2RA 32%, NNT 4 moderate QOE Reflux (erosive) esophagitis 29,30 Usual Tx: 8 wks H. PYLORI ERADICATION REGIMENS H. pylori Eradication Regimens 1-2-3 Cured March 1999 Highlights • H. pylori eradication drastically reduces ulcer recurrence in patients with duodenal or gastric ulcers. • 7-day triple therapies with a proton pump inhibitor (PPI) + two antibiotics given BID are currently SAMPLE PATIENT AGREEMENT FOR LONG-TERM OPIOID THERAPY Appendix A See www.RxFiles.ca for customizable form (MS-Word format) for your office. Dirct link: http://www.rxfiles.ca/rxfiles/uploads/documents/Pain-CNMP-Opioid RXFILESOUR RESOURCESSTORESIGN UPCONTACT USPATIENT EDUCATIONPASSWORDRECOVERY
RxFiles. RxFiles Academic Detailing is a Canadian drug information resource. Our website is built to help answer your drug therapy questions through objective comparisons. We pursue a balanced, independent approach. We do NOT receive funding from the pharmaceutical industry. RXFILES | LOGINSIGN UPRXFILES APPS Switch to Desktop Version. Your IP Address Is 157.55.39.53 RXFILES DIABETES BOOK Diabetes Patient Booklet. A patient booklet for patients with type 2 diabetes, designed to motivate patients to exercise, take their medications regularly, test their sugars only when needed, inject insulin properly, and hold SADMANS medications when dehydrated. RX FILES: Q&A SUMMARY Rx Files: Q&A Summary www.RxFiles.ca - Updated May 2021 Originally prepared by: M Jin, PharmD Non-Live Recombinant Herpes Zoster Vaccine (SHINGRIX) l What is SHINGRIX?1,2,3,4,5,6,7,8 Herpes Zoster (shingles) vaccine contains NON-live, recombinant, AS01B adjuvanted herpes zoster vaccine. This vaccine contains antigen IS APIXABAN (ELIQUIS®) AN OPTION FOR YOUR PATIENT CLOT Page 1 of 2 Collaborative Learning on Thrombosis (CLOT) – Canadian Prairie pharmacists with an interest in thromboembolic disorders This is intended only as a general reference to supplement existing knowledge of healthcare professionals in Canada & is not a substitute for sound clinical THIS HANDOUT IS IN GENERAL TYPE 2 DIABETES AND SICK DAYS I will increase the number of times I RECORD (check) my blood glucose levels when I am sick. If they are too high or too low, I will contact my health care provider. When you are sick, it is easy to become dehydrated from throwing up, diarrhea, and/or a fever. ANTIBIOTICS & COMMON INFECTIONS Antibiotics & Common Infections ABX-2: Uncomplicated Cystitis & Skin Stewardship, Effectiveness, Safety & Clinical Pearls- April 2017 ABX-2RELATED LINKS
ONYCHOMYCOSIS TREATMENT Select drug interactions with antifungals 20 • Terbinafine has minimal significant drug interactions and is a good antifungal option for patients on multiple drug regimens. BUPRENORPHINE/NALOXONE SUBOXONE GUIDE DOSAGE … BUPRENORPHINE/NALOXONE SUBOXONE GUIDE DOSAGE FORMS DOSING: INDUCTION (methods for initiating someone) Generic: 2mg/0.5mg, 8mg/2mg Brand: 2mg/0.5mg, 8mg/ 2mg, 12mg/3mg, 16mg/4mg (need to order; not often stocked) Can be split/ crushed to ease dosingDEMENTIA - RXFILES
DEMENTIA BRINGING EVIDENCE & EXPERIENCE TO DRUG THERAPY DECISION POINTS October 2014 INSIDE Pg 3: Cholinesterase Inhibitors (ChEI) in Dementia Pg 7: Geri‐RxFiles ‐ Dementia & Cognitive Impairment Pg 12: Geri‐RxFiles – Anticholinergics Reference List Pg 13: Geri‐RxFiles – Dementia: RXFILESOUR RESOURCESSTORESIGN UPCONTACT USPATIENT EDUCATIONPASSWORDRECOVERY
RxFiles. RxFiles Academic Detailing is a Canadian drug information resource. Our website is built to help answer your drug therapy questions through objective comparisons. We pursue a balanced, independent approach. We do NOT receive funding from the pharmaceutical industry. RXFILES | LOGINSIGN UPRXFILES APPS Switch to Desktop Version. Your IP Address Is 157.55.39.53 RXFILES DIABETES BOOK Diabetes Patient Booklet. A patient booklet for patients with type 2 diabetes, designed to motivate patients to exercise, take their medications regularly, test their sugars only when needed, inject insulin properly, and hold SADMANS medications when dehydrated. RX FILES: Q&A SUMMARY Rx Files: Q&A Summary www.RxFiles.ca - Updated May 2021 Originally prepared by: M Jin, PharmD Non-Live Recombinant Herpes Zoster Vaccine (SHINGRIX) l What is SHINGRIX?1,2,3,4,5,6,7,8 Herpes Zoster (shingles) vaccine contains NON-live, recombinant, AS01B adjuvanted herpes zoster vaccine. This vaccine contains antigen IS APIXABAN (ELIQUIS®) AN OPTION FOR YOUR PATIENT CLOT Page 1 of 2 Collaborative Learning on Thrombosis (CLOT) – Canadian Prairie pharmacists with an interest in thromboembolic disorders This is intended only as a general reference to supplement existing knowledge of healthcare professionals in Canada & is not a substitute for sound clinical THIS HANDOUT IS IN GENERAL TYPE 2 DIABETES AND SICK DAYS I will increase the number of times I RECORD (check) my blood glucose levels when I am sick. If they are too high or too low, I will contact my health care provider. When you are sick, it is easy to become dehydrated from throwing up, diarrhea, and/or a fever. ANTIBIOTICS & COMMON INFECTIONS Antibiotics & Common Infections ABX-2: Uncomplicated Cystitis & Skin Stewardship, Effectiveness, Safety & Clinical Pearls- April 2017 ABX-2RELATED LINKS
ONYCHOMYCOSIS TREATMENT Select drug interactions with antifungals 20 • Terbinafine has minimal significant drug interactions and is a good antifungal option for patients on multiple drug regimens. BUPRENORPHINE/NALOXONE SUBOXONE GUIDE DOSAGE … BUPRENORPHINE/NALOXONE SUBOXONE GUIDE DOSAGE FORMS DOSING: INDUCTION (methods for initiating someone) Generic: 2mg/0.5mg, 8mg/2mg Brand: 2mg/0.5mg, 8mg/ 2mg, 12mg/3mg, 16mg/4mg (need to order; not often stocked) Can be split/ crushed to ease dosingDEMENTIA - RXFILES
DEMENTIA BRINGING EVIDENCE & EXPERIENCE TO DRUG THERAPY DECISION POINTS October 2014 INSIDE Pg 3: Cholinesterase Inhibitors (ChEI) in Dementia Pg 7: Geri‐RxFiles ‐ Dementia & Cognitive Impairment Pg 12: Geri‐RxFiles – Anticholinergics Reference List Pg 13: Geri‐RxFiles – Dementia:RXFILES | LOGIN
Switch to Desktop Version. Your IP Address Is 157.55.39.53RXFILES PAIN BOOK
Managing acute-on-chronic-opioid pain is challenging; this chart offers tips for managing acute pain for patients already on codeine, fentanyl, heroin, hydromorphone, morphine, oxycodone, tapentadol, tramadol, methadone, or buprenorphine. RXFILES DRUG COMPARISON CHARTS rxfiles.ca/charts. The 12th collected edition of our objective & comparative drug charts. Table of Contents Indices Full ReferenceList.
DECLARE-TIMI 58- DAPAGLIFLOZIN VS PLACEBO IN T2DM + CVD RXFILES TRIAL SUMMARY BSP 2019 T D 2019JONATHAN DEROOSE CANDIDATE , WWWTAISA RISCHUK PHARM AUG – .RXFILES.CA Page 1 of 3 DECLARE-TIMI 58: Dapagliflozin vs Placebo in T2DM + CVD/Major Risk Factors 1 Dapagliflozin Effect on CardiovascuLAR Events-Thrombolysis In IS RIVAROXABAN (XARELTO®) AN OPTION FOR YOUR PATIENT CLOT Page 1 of 2 Collaborative Learning on Thrombosis (CLOT) – Canadian Prairie pharmacists with an interest in thromboembolic disorders This is intended only as a general reference to supplement existing knowledge of healthcare professionals in Canada & is not a substitute for sound clinicalRXFILES
Geri-RxFiles focuses on drug therapy for older adults and long-term care.We hope this resource helps you to navigate the complexities and pitfalls of drug therapy in this age group.DEMENTIA - RXFILES
DEMENTIA BRINGING EVIDENCE & EXPERIENCE TO DRUG THERAPY DECISION POINTS October 2014 INSIDE Pg 3: Cholinesterase Inhibitors (ChEI) in Dementia Pg 7: Geri‐RxFiles ‐ Dementia & Cognitive Impairment Pg 12: Geri‐RxFiles – Anticholinergics Reference List Pg 13: Geri‐RxFiles – Dementia: SHOULD ASA BE USED FOR PRIMARY PREVENTION OF RxFiles Q&A L Kosar, M Jin Dec 2019 www.RxFiles.ca Prior guidelines gave conflicting messages on the role of ASA for primary prevention. Two guideline committees have updated their statements based on the new studies: – 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease:9 ASA 75-100mg daily might be considered for the primary prevention of ASCVD among select adults 40 OPIOID PATCH EXCHANGE DISPOSAL TOOL E.G. FENTANYL Opioid Patch Exchange Disposal Tool E.g. Fentanyl DURAGESIC patch, Buprenorphine BUTRANS patch Affix used patch to this sheet once removed from skin 2 Affix used patch to sheet once removed SAMPLE PATIENT AGREEMENT FOR LONG-TERM OPIOID THERAPY Appendix A See www.RxFiles.ca for customizable form (MS-Word format) for your office. Dirct link: http://www.rxfiles.ca/rxfiles/uploads/documents/Pain-CNMP-OpioidRxFiles
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RXFILES ACADEMIC DETAILING is a Canadian drug information resource. Our website is built to help answer your drug therapy questions through objective comparisons. We pursue a balanced, independent approach. We do NOT receive funding from the pharmaceutical industry. A small taste of some of our tools: HAVE YOU EVER NEEDED TO ... adjust the dose of warfarin?
pick an inhaler devicefor a COPD patient?
encourage a patient
to start exercising?check the spectrum
of an antibiotic?
loosen diabetic targets for a frail older adult? look up the target doses of ACEIs, ARBs, or beta-blockers in heart failure? encourage a patient on opioids to consider tapering?
find out which antipsychotics have the lowest weight gain?
talk to a patient about cannabis use?
find out the number of years to continue a bisphosphonate?
pick an SSRI with the least anticholinergiceffects?
compare relative pricing of different antimuscarinics?
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from one antidepressant to another? get an idea of weight gain differences between diabetes meds? weigh the advantages and disadvantages of chronic pain medications?
find out if a medication is safe to crush in a patient with difficulty swallowing? look up a generic birth controlsubstitution?
Our program began in 1997as
a service to Saskatoon physicians. In 2000, the program was expanded to provide service to physicians throughout Saskatchewan. Efforts to keep our drug selection tools up to date resulted in the publication of the RxFiles Drug Comparison Charts book, beginning in 2001. Ourbook
has become a practical tool for evidence-based and clinically relevant drug use information throughout Canada. On our website, you will find our newsletter reviews,
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