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microtome.
DISTRIBUTORS
We are always seeking out partners with whom we can work with to push the boundaries of science and enable new discoveries. If you or your company are interested in working with us, please contactWHY COMPRESSTOME?
This compression helps stabilize the tissue during sectioning, and allows the Compresstome ® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome ® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices.PRECISIONARY
20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models. PRECISIONARY CRYOSTAT CF-6100 To promote and support high quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freeze microtome. Key Features Extra large freeze chamber has UV light sterilization, automatic defrost, and standby mode. LED touchscreen control panel is large andeasy to use.
EXPERIMENT | PRECISIONARY 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.PRECISIONARY
The VF-300-0Z is the Auto Zero-Z® version of our workhorse Compresstome®. With our compression technology, this fully automated slicer excels at sectioning slices used for: Our slicer technology allows you to double your slice viability. The Compresstome® is alsoeasy to use.
TROUBLESHOOTING CRYOSTAT SECTIONING PROBLEMS Clean the cutting blade, or move the blade to a new section for cutting. Sometimes you may need to replace the blade. Figure 2. Frozen tissue cut on the cryostat may have unwanted streaks and cracks (left), freeze artifacts (middle), or smudges and chopped sections (C). Tissue sticks to the brush or rips.PRECISIONARY
VF-700-0Z. The VF-700-0Z is designed specifically for sectioning fixed tissues. With a wider diameter of 21 mm, it can accommodate both rat and mice brains. With our patented compression technology, this fully automated slicer excels at sectioning slices used for: The Auto Zero-Z® technology eliminates any need for your own Z axis tuning. SAFETY OF AGAROSE EMBEDDING There are two methods for this: the first is to dip your tissue sample into a 30% sucrose solution before embedding, and this will act as a gentle “film” between your sample and the agar rim, aiding the agar rim to fall off after the slice is cut. The second method is to use a higher concentration of agarose when preparing your solution. PRECISIONARY COMPRESSTOME VIBRATING MICROTOME TISSUE SLICERSUPPORTBLOGE-STOREABOUT USDISTRIBUTORSPRECISIONARY GUARANTEE Precisionary Cryostat CF-6100 Innovative Research & Clinical Cryostat Newly Designed Cryostat. To promote and support high-quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freezemicrotome.
DISTRIBUTORS
We are always seeking out partners with whom we can work with to push the boundaries of science and enable new discoveries. If you or your company are interested in working with us, please contactWHY COMPRESSTOME?
This compression helps stabilize the tissue during sectioning, and allows the Compresstome ® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome ® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices.PRECISIONARY
20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models. PRECISIONARY CRYOSTAT CF-6100 To promote and support high quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freeze microtome. Key Features Extra large freeze chamber has UV light sterilization, automatic defrost, and standby mode. LED touchscreen control panel is large andeasy to use.
EXPERIMENT | PRECISIONARY 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.PRECISIONARY
The VF-300-0Z is the Auto Zero-Z® version of our workhorse Compresstome®. With our compression technology, this fully automated slicer excels at sectioning slices used for: Our slicer technology allows you to double your slice viability. The Compresstome® is alsoeasy to use.
TROUBLESHOOTING CRYOSTAT SECTIONING PROBLEMS Clean the cutting blade, or move the blade to a new section for cutting. Sometimes you may need to replace the blade. Figure 2. Frozen tissue cut on the cryostat may have unwanted streaks and cracks (left), freeze artifacts (middle), or smudges and chopped sections (C). Tissue sticks to the brush or rips.PRECISIONARY
VF-700-0Z. The VF-700-0Z is designed specifically for sectioning fixed tissues. With a wider diameter of 21 mm, it can accommodate both rat and mice brains. With our patented compression technology, this fully automated slicer excels at sectioning slices used for: The Auto Zero-Z® technology eliminates any need for your own Z axis tuning. SAFETY OF AGAROSE EMBEDDING There are two methods for this: the first is to dip your tissue sample into a 30% sucrose solution before embedding, and this will act as a gentle “film” between your sample and the agar rim, aiding the agar rim to fall off after the slice is cut. The second method is to use a higher concentration of agarose when preparing your solution. PRECISIONARY PUBLICATIONS The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics. PLoS One. 2017 Rosner SR, Pascoe CD, Blankman E, et al. 2017. Rosner SR, Pascoe CD, Blankman E, et al. Integrated Organotypic Slice Cultures and RT-QuIC (OSCAR) Assay: Implications for Translational Discovery in Protein MisfoldingDiseases.
PRECISIONARY
The VF-300-0Z is the Auto Zero-Z® version of our workhorse Compresstome®. With our compression technology, this fully automated slicer excels at sectioning slices used for: Our slicer technology allows you to double your slice viability. The Compresstome® is alsoeasy to use.
PRECISIONARY ROTARY MICROTOMES At Precisionary Instruments, we provide 3 different models of rotary microtomes to meet your histology and pathology needs: RF-600 (Manual) RF-800 (Semi-automated) RF-1000 (Fully automated) These rotary microtomes are designed to cut paraffin-embedded tissue samples in cassette for pathology studies, and can also be used for academic research to cut frozen and fixed tissue specimens.PRECISIONARY
The Compresstome® is the most widely used tissue slicer in the United States for making precision-cut lung slices, providing healthier tissue for studies of respiratory physiology. For studies of lung anatomy and microstructures, the Compresstome® tissue slicer can section lung tissue as thin as 4µm.PRECISIONARY
VF-700-0Z. The VF-700-0Z is designed specifically for sectioning fixed tissues. With a wider diameter of 21 mm, it can accommodate both rat and mice brains. With our patented compression technology, this fully automated slicer excels at sectioning slices used for: The Auto Zero-Z® technology eliminates any need for your own Z axis tuning. VF-200 - PRECISIONARY.COM The VF-200 is our entry level Compresstome®. With our compression technology, this semi-automated slicer excels at sectioning slices used for: Our patented slicer technology allows you to double your slice viability for healthier tissue. The Compresstome® produces beautiful sections while providing a fast user-friendly cuttingexperience.
PRECISIONARY
Renal system (Precisionary-cut kidney slices) Precision-cut slices require healthy, viable tissue slices in order for metabolism studies to yield accurate results. Slicing is the first and most important step of this procedure. The ability to cut the perfect tissue slice to minimize cellular damage is PRECISIONARY INSTRUMENTS Figure 1. Single permanent tempered steel cryostat blade (left) with wooden storage box (right). The latest cryostats use disposable blades, which are much easier to handle and often provide superior cut quality. Disposable blades conveniently come in blade-dispensing boxes. These types of blades come in low profile and high profilestypes (see
PRECISIONARY INSTRUMENTS The cryostat should be located in an easily accessible area. Key components of the cryostat include the microtome, cryochamber, blade holder, handwheel, and freeze plate. For Mohs surgery samples, the cryostat should be kept between -20 and -25 C. The cryostat for dermatology needs to have a robust freeze system, because multiplefrozen samples
SAFETY OF AGAROSE EMBEDDING There are two methods for this: the first is to dip your tissue sample into a 30% sucrose solution before embedding, and this will act as a gentle “film” between your sample and the agar rim, aiding the agar rim to fall off after the slice is cut. The second method is to use a higher concentration of agarose when preparing your solution. PRECISIONARY COMPRESSTOME VIBRATING MICROTOME TISSUE SLICERSUPPORTBLOGE-STOREABOUT USDISTRIBUTORSPRECISIONARY GUARANTEELEICA MICROTOME BLADEPRECISIONARY INSTRUMENTS LLCPRECISIONARY INSTRUMENTS INCCOMPRESSTOME Precisionary Cryostat CF-6100 Innovative Research & Clinical Cryostat Newly Designed Cryostat. To promote and support high-quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freezemicrotome.
PRECISIONARY E-STORE 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.OUR SLICERS
The Compresstome® vibrating microtome models are unique for many reasons. The major reason is the patented compression technology that is equipped with our slicers only.PRECISIONARY
20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.WHY COMPRESSTOME?
This compression helps stabilize the tissue during sectioning, and allows the Compresstome ® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome ® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices. PRECISIONARY CRYOSTAT CF-6100 To promote and support high quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freeze microtome. Key Features Extra large freeze chamber has UV light sterilization, automatic defrost, and standby mode. LED touchscreen control panel is large andeasy to use.
EXPERIMENT | PRECISIONARY 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models. TROUBLESHOOTING CRYOSTAT SECTIONING PROBLEMS Clean the cutting blade, or move the blade to a new section for cutting. Sometimes you may need to replace the blade. Figure 2. Frozen tissue cut on the cryostat may have unwanted streaks and cracks (left), freeze artifacts (middle), or smudges and chopped sections (C). Tissue sticks to the brush or rips.PRECISIONARY
The VF-300-0Z is the Auto Zero-Z® version of our workhorse Compresstome®. With our compression technology, this fully automated slicer excels at sectioning slices used for: Our slicer technology allows you to double your slice viability. The Compresstome® is alsoeasy to use.
PRECISIONARY
VF-700-0Z. The VF-700-0Z is designed specifically for sectioning fixed tissues. With a wider diameter of 21 mm, it can accommodate both rat and mice brains. With our patented compression technology, this fully automated slicer excels at sectioning slices used for: The Auto Zero-Z® technology eliminates any need for your own Z axis tuning. PRECISIONARY COMPRESSTOME VIBRATING MICROTOME TISSUE SLICERSUPPORTBLOGE-STOREABOUT USDISTRIBUTORSPRECISIONARY GUARANTEELEICA MICROTOME BLADEPRECISIONARY INSTRUMENTS LLCPRECISIONARY INSTRUMENTS INCCOMPRESSTOME Precisionary Cryostat CF-6100 Innovative Research & Clinical Cryostat Newly Designed Cryostat. To promote and support high-quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freezemicrotome.
PRECISIONARY E-STORE 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.OUR SLICERS
The Compresstome® vibrating microtome models are unique for many reasons. The major reason is the patented compression technology that is equipped with our slicers only.PRECISIONARY
20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.WHY COMPRESSTOME?
This compression helps stabilize the tissue during sectioning, and allows the Compresstome ® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome ® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices. PRECISIONARY CRYOSTAT CF-6100 To promote and support high quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freeze microtome. Key Features Extra large freeze chamber has UV light sterilization, automatic defrost, and standby mode. LED touchscreen control panel is large andeasy to use.
EXPERIMENT | PRECISIONARY 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models. TROUBLESHOOTING CRYOSTAT SECTIONING PROBLEMS Clean the cutting blade, or move the blade to a new section for cutting. Sometimes you may need to replace the blade. Figure 2. Frozen tissue cut on the cryostat may have unwanted streaks and cracks (left), freeze artifacts (middle), or smudges and chopped sections (C). Tissue sticks to the brush or rips.PRECISIONARY
The VF-300-0Z is the Auto Zero-Z® version of our workhorse Compresstome®. With our compression technology, this fully automated slicer excels at sectioning slices used for: Our slicer technology allows you to double your slice viability. The Compresstome® is alsoeasy to use.
PRECISIONARY
VF-700-0Z. The VF-700-0Z is designed specifically for sectioning fixed tissues. With a wider diameter of 21 mm, it can accommodate both rat and mice brains. With our patented compression technology, this fully automated slicer excels at sectioning slices used for: The Auto Zero-Z® technology eliminates any need for your own Z axis tuning. PRECISIONARY E-STORE 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.OUR SLICERS
The Compresstome® vibrating microtome models are unique for many reasons. The major reason is the patented compression technology that is equipped with our slicers only.WHY COMPRESSTOME?
This compression helps stabilize the tissue during sectioning, and allows the Compresstome ® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome ® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices.BY EXPERIMENT
The key to performing the best tissue culture experiments is to use healthy tissue slices. Traditional slicing with tissue choppers cause tearing and stretching of samples. Our Compresstome® is able to hold your tissue sample firmly in place while sectioning, providing maximum support. This produces perfect slices for slice culture experiments. INTRODUCING OUR NEW ROTARY MICROTOMES! Explore how Visikol uses the Compresstome VF-310-0Z to cut precision-cut liver slices for slice cultures & assays.PRECISIONARY
Compresstome VF-310-0Z vibrating microtome training videos. Information for cutting parameters, agarose embedding, plating slices,& the buffer tray.
PRECISIONARY|COMPRESSTOME FOR ELECTROPHYSIOLOGY The viability of the brain slice, especially the healthy neurons in the top surface layers are crucial to the success of brain slice patch clamp electrophysiology. The Compresstome® semi-automated VF-200-0Z and fully automated VF-300-0 Z produce the highest quality brain slices for these researches.PRECISIONARY
The Compresstome® is the most widely used tissue slicer in the United States for making precision-cut lung slices, providing healthier tissue for studies of respiratory physiology. For studies of lung anatomy and microstructures, the Compresstome® tissue slicer can section lung tissue as thin as 4µm.PRECISIONARY
The VF-300-0Z is the Auto Zero-Z® version of our workhorse Compresstome®. With our compression technology, this fully automated slicer excels at sectioning slices used for: Our slicer technology allows you to double your slice viability. The Compresstome® is alsoeasy to use.
PRECISIONARY
VF-700-0Z. The VF-700-0Z is designed specifically for sectioning fixed tissues. With a wider diameter of 21 mm, it can accommodate both rat and mice brains. With our patented compression technology, this fully automated slicer excels at sectioning slices used for: The Auto Zero-Z® technology eliminates any need for your own Z axis tuning. PRECISIONARY COMPRESSTOME VIBRATING MICROTOME TISSUE SLICERSUPPORTBLOGE-STOREABOUT USDISTRIBUTORSPRECISIONARY GUARANTEELEICA MICROTOME BLADEPRECISIONARY INSTRUMENTS LLCPRECISIONARY INSTRUMENTS INCCOMPRESSTOME Precisionary Cryostat CF-6100 Innovative Research & Clinical Cryostat Newly Designed Cryostat. To promote and support high-quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freezemicrotome.
PRECISIONARY E-STORE 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.OUR SLICERS
The Compresstome® vibrating microtome models are unique for many reasons. The major reason is the patented compression technology that is equipped with our slicers only.PRECISIONARY
20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.WHY COMPRESSTOME?
This compression helps stabilize the tissue during sectioning, and allows the Compresstome ® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome ® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices. PRECISIONARY CRYOSTAT CF-6100 To promote and support high quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freeze microtome. Key Features Extra large freeze chamber has UV light sterilization, automatic defrost, and standby mode. LED touchscreen control panel is large andeasy to use.
EXPERIMENT | PRECISIONARY 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models. TROUBLESHOOTING CRYOSTAT SECTIONING PROBLEMS Clean the cutting blade, or move the blade to a new section for cutting. Sometimes you may need to replace the blade. Figure 2. Frozen tissue cut on the cryostat may have unwanted streaks and cracks (left), freeze artifacts (middle), or smudges and chopped sections (C). Tissue sticks to the brush or rips.PRECISIONARY
The VF-300-0Z is the Auto Zero-Z® version of our workhorse Compresstome®. With our compression technology, this fully automated slicer excels at sectioning slices used for: Our slicer technology allows you to double your slice viability. The Compresstome® is alsoeasy to use.
PRECISIONARY
VF-700-0Z. The VF-700-0Z is designed specifically for sectioning fixed tissues. With a wider diameter of 21 mm, it can accommodate both rat and mice brains. With our patented compression technology, this fully automated slicer excels at sectioning slices used for: The Auto Zero-Z® technology eliminates any need for your own Z axis tuning. PRECISIONARY COMPRESSTOME VIBRATING MICROTOME TISSUE SLICERSUPPORTBLOGE-STOREABOUT USDISTRIBUTORSPRECISIONARY GUARANTEELEICA MICROTOME BLADEPRECISIONARY INSTRUMENTS LLCPRECISIONARY INSTRUMENTS INCCOMPRESSTOME Precisionary Cryostat CF-6100 Innovative Research & Clinical Cryostat Newly Designed Cryostat. To promote and support high-quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freezemicrotome.
PRECISIONARY E-STORE 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.OUR SLICERS
The Compresstome® vibrating microtome models are unique for many reasons. The major reason is the patented compression technology that is equipped with our slicers only.PRECISIONARY
20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.WHY COMPRESSTOME?
This compression helps stabilize the tissue during sectioning, and allows the Compresstome ® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome ® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices. PRECISIONARY CRYOSTAT CF-6100 To promote and support high quality tissue sectioning in pathology, dermatology, and histology labs, we have designed and created the CF-6100 cryostat as a state-of-the-art freeze microtome. Key Features Extra large freeze chamber has UV light sterilization, automatic defrost, and standby mode. LED touchscreen control panel is large andeasy to use.
EXPERIMENT | PRECISIONARY 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models. TROUBLESHOOTING CRYOSTAT SECTIONING PROBLEMS Clean the cutting blade, or move the blade to a new section for cutting. Sometimes you may need to replace the blade. Figure 2. Frozen tissue cut on the cryostat may have unwanted streaks and cracks (left), freeze artifacts (middle), or smudges and chopped sections (C). Tissue sticks to the brush or rips.PRECISIONARY
The VF-300-0Z is the Auto Zero-Z® version of our workhorse Compresstome®. With our compression technology, this fully automated slicer excels at sectioning slices used for: Our slicer technology allows you to double your slice viability. The Compresstome® is alsoeasy to use.
PRECISIONARY
VF-700-0Z. The VF-700-0Z is designed specifically for sectioning fixed tissues. With a wider diameter of 21 mm, it can accommodate both rat and mice brains. With our patented compression technology, this fully automated slicer excels at sectioning slices used for: The Auto Zero-Z® technology eliminates any need for your own Z axis tuning. PRECISIONARY E-STORE 20% OFF MEGASALE EVENT! Valid only on all Compresstome® VF-310-0Z and VF-210-0Z vibrating microtomes Promotion Ends May 31, 2021 *Valid only for VF-310-0Z and VF-210-0Z models.OUR SLICERS
The Compresstome® vibrating microtome models are unique for many reasons. The major reason is the patented compression technology that is equipped with our slicers only.WHY COMPRESSTOME?
This compression helps stabilize the tissue during sectioning, and allows the Compresstome ® to section at speeds up to 5x faster than other market vibrating microtomes. Overall, the Compresstome ® provides a significant improvement on the health and longevity of live slices, and virtually eliminates chattermarks in fixed tissue slices.BY EXPERIMENT
The key to performing the best tissue culture experiments is to use healthy tissue slices. Traditional slicing with tissue choppers cause tearing and stretching of samples. Our Compresstome® is able to hold your tissue sample firmly in place while sectioning, providing maximum support. This produces perfect slices for slice culture experiments. INTRODUCING OUR NEW ROTARY MICROTOMES! Explore how Visikol uses the Compresstome VF-310-0Z to cut precision-cut liver slices for slice cultures & assays.PRECISIONARY
Compresstome VF-310-0Z vibrating microtome training videos. Information for cutting parameters, agarose embedding, plating slices,& the buffer tray.
PRECISIONARY|COMPRESSTOME FOR ELECTROPHYSIOLOGY The viability of the brain slice, especially the healthy neurons in the top surface layers are crucial to the success of brain slice patch clamp electrophysiology. The Compresstome® semi-automated VF-200-0Z and fully automated VF-300-0 Z produce the highest quality brain slices for these researches.PRECISIONARY
The Compresstome® is the most widely used tissue slicer in the United States for making precision-cut lung slices, providing healthier tissue for studies of respiratory physiology. For studies of lung anatomy and microstructures, the Compresstome® tissue slicer can section lung tissue as thin as 4µm.PRECISIONARY
The VF-300-0Z is the Auto Zero-Z® version of our workhorse Compresstome®. With our compression technology, this fully automated slicer excels at sectioning slices used for: Our slicer technology allows you to double your slice viability. The Compresstome® is alsoeasy to use.
PRECISIONARY
VF-700-0Z. The VF-700-0Z is designed specifically for sectioning fixed tissues. With a wider diameter of 21 mm, it can accommodate both rat and mice brains. With our patented compression technology, this fully automated slicer excels at sectioning slices used for: The Auto Zero-Z® technology eliminates any need for your own Z axis tuning.Skip to content
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*VF-310-0Z Shown Here 25% OFF MEGASALE EVENT! VALID ONLY ON ALL COMPRESSTOME® VF-310-0Z AND VF-210-0Z VIBRATINGMICROTOMES
PROMOTION ENDS MARCH 31, 2020Find Out More
Get Your 25% Discount * Does not include purchase from the following countries: Those underChina and Japan.
* Valid only on all VF-310-0Z, and VF-210-0Z sales, Does not include additional accessory purchases. COMPRESSTOME® QUOTE FORM* Full Name*
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● NEW, improved vibrating microtome ● Easier to use, easier to clean ● Produces healthier live tissue slices ● Produces thin, consistent fixed slices ● Auto Zero-Z® technology ● Can cut thicknesses 4µm to 1000µm ● Maximum tissue diameter: 20mm ● Maximum tissue length: 2.5cm● Fully automated
Best Seller!
VF-310-0Z Model
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● Produces healthy acute slices ● Produces even consistent slices ● Cuts slice thickness from 10µm to 1000µm ● Auto Zero-Z patented technology ● Eliminates chatter marks ● Holds specimens up to 20mm diameter ● Removable buffer tray for easy cleaning ● Easy to attach/remove blade holder ● Superior durability and quality ● New build, Low PriceVF-210-0Z Model
Learn More
We offer a wide selection of both fully automatic and semi-automatic tissue slicers that are capable in accommodating to a much larger range of tissue sizes for your experimental needs.Explore the
Legacy Line
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● NEW, improved vibrating microtome ● Easier to use, easier to clean ● Produces healthier live tissue slices ● Produces thin, consistent fixed slices ● Auto Zero-Z® technology ● Can cut thicknesses 4µm to 1000µm ● Maximum tissue diameter: 20mm ● Maximum tissue length: 2.5cm● Fully automated
Best Seller!
VF-310-0Z Model
Learn More
● Produces healthy acute slices ● Produces even consistent slices ● Cuts slice thickness from 10µm to 1000µm ● Auto Zero-Z patented technology ● Eliminates chatter marks ● Holds specimens up to 20mm diameter ● Removable buffer tray for easy cleaning ● Easy to attach/remove blade holder ● Superior durability and quality ● New build, Low PriceVF-210-0Z Model
Learn More
We offer a wide selection of both fully automatic and semi-automatic tissue slicers that are capable in accommodating to a much larger range of tissue sizes for your experimental needsExplore the
Legacy Line
PRICE MATCH GUARANTEE! We won’t be beaten on price. We’ll match any qualifying competitor’s quote!* Quote
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RESEARCH AND CLINICAL APPLICATIONSELECTROPHYSIOLOGY
_Produce healthier slices for patch-clamp, field recordings, andcalcium imaging._
IMMUNOHISTOCHEMISTRY (IHC) _Cuts smooth, consistent tissue slices for protein staining._ IN-SITU HYBRIDIZATION (ISH) _Create consistent, thin sections to stain for DNA, RNA, and nucleicacids_
PATHOLOGY & HISTOLOGY _Create thin tissue sections for H&E, Nissl and special stains forcellular studies._
PRECISION-CUT SLICES _Generate healthy consistent slices for physiology and toxicologystudies._
CULTURED SLICES
_Start making live, organotypic slices for culture studies in tumorresearch_
HOW CAN THE COMPRESSTOME® HELP YOU? Search by Experiment Select Electrophysiology IHC: lmmunohistochemistry PCLS: Precision-Cut Lung Slices In Situ Hybridization Organotypic Cultures Search by Tissue Type Select Brain (Fixed) Brain (Live/Fresh) Heart Tumor Lung Lymph Node Muscle Reproductive Search by Animal Model Select Mice Rat Human Non-Human Primates Fish Chick (gallus gallus) Frog Guinea Pig Pigs Plants SEE WHAT THE TOP RESEARCHERS IN THE FIELD ARE SAYING ABOUT THECOMPRESSTOME®!
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“THE VF-300 IS MORE CONSISTENT IN GENERATING UNIFORM SLICES AND LEAVES THE STRUCTURE OF THE TISSUE/CELLS MORE INTACT THAN THE METHOD WE HAD BEEN USING. WE HAVE BEEN ABLE TO EXTEND THE AMOUNT OF TIME OVER WHICH WE CAN CUT LUNG SLICES, AND ALLOWS PRESERVATION OF THE ARCHITECTURE OF THE SLICE AND GREATER VIABILITY OF THE TISSUE.” _-DR. CYNTHIA KOZIAL-WHITE, UNIVERSITY OF PENNSYLVANIA_ “CURRENTLY, WE ARE ABLE TO ROUTINELY PERFORM (ON A DAILY BASIS) PATCH-CLAMP RECORDINGS FROM MECHANICALLY-DISSOCIATED NEURONS WITH ADHERENT BOUTONS ONLY WHEN USING THE VF-200, WHICH WAS PREVIOUSLY UNOBTAINABLE USING VIBRATING MICROTOMES PURCHASED FROM OTHER LEADINGCOMPANIES.”
_-DR. JIE WU, DIRECTOR OF EPILEPSY RESEARCH, BARROW NEUROLOGICALINSTITUTE_
“THE MAIN ADVANTAGES OF THIS MACHINE ARE THE RAPID SPEED OF SLICING AND THE MANUAL STABILIZATION AFFORDED BY THE AGAROSE EMBEDDING. I AM ABLE TO PREPARE UNIFORM SLICES IN BOTH THE CORONAL AND HORIZONTAL PLANES, AND I ROUTINELY COMPLETE TRANSCARDIAL PERFUSION, BRAIN REMOVAL, AND SLICING ALL WITHIN LESS THAN 10 MINUTES, WHICH IS HALF THE TIME NEEDED WITH THE VIBRATING MICROTOME MODEL.” _-DR. JONATHAN TING, ALLEN INSTITUTE_ “E HAVE EXPERIENCE USING A VARIETY OF MICROTOMES FROM DIFFERENT VENDORS, WE WERE EXCITED BY THE VF-300’S ABILITY TO PROVIDESUPERIOR SLICES.”
_-DR. YAN GU AND DR. SHAOYU GE, DEPARTMENT OF NEUROBIOLOGY, SUNY ATSTONY BROOK_
“I HAVE BEEN CONSISTENTLY CUTTING EXCEPTIONAL QUALITY BRAIN SLICES AND HAVE SUCCEEDED IN OBTAINING STABLE WHOLE-CELL PATCH RECORDINGS FROM NUMEROUS NEURONS.” _-DR. NEWTON WOO, PHD NICHD/NIH_ “IMMEDIATELY WE EXPERIENCED SUCCESS IN OBTAINING MECHANICALLY-DISSOCIATED NEURONS WITH ADHERENT PRE-SYNAPTIC BOUTONS USING THE MICROTOME FROM PRECISIONARY INSTRUMENTS, INC., AND WE ALSO NOTICED CELL QUALITY WAS MUCH HIGHER WHEN COMPARED TO NEURONS OBTAINED USING THE OTHER VIBRATING MICROTOMES”. _-DR. JIE WU, DIRECTOR OF EPILEPSY RESEARCH, BARROW_ _NEUROLOGICALINSTITUTE_
“WHEN I USE THE VF-200, I HAVE A SIGNIFICANTLYGREATER NUMBER OF SURFACE NEURONS THAN THOSE SLICES CUT FROM A REGULAR VIBRATING MICROTOME. IN ADDITION THE SLICE SURFACE IS MUCH MORE EVEN, WHICH ALLOWS FOR BETTER IMAGING.” _-DR. NEWTON WOO, PHD NICHD/NIH_ “WE OBTAINED SURPRISINGLY GOOD ELECTROPHYSIOLOGY RESULTS FROM EVEN SLICES OF RELATIVELY OLD (6 WEEK) ANIMALS. THE SLICES WERE VERY CLEAN ON THE SURFACE, AND THE MAJORITY OF THE CELLS WERE ALIVE INCLUDING THOSE VERY CLOSE TO THE SURFACE.” _-DR. YAN GU AND DR. SHAOYU GE, DEPARTMENT OF NEUROBIOLOGY, SUNY ATSTONY BROOK_
“I AM THOROUGHLY IMPRESSED WITH THE VF-200 AND WOULD NOT HESITATE RECOMMENDING THIS QUALITY PRODUCT TO FELLOW ELECTROPHYSIOLOGISTS.” _-DR. NEWTON WOO, PHD NICHD/NIH_ “WE FOUND THE COMPRESSTOME PRODUCES A LESS APPARENT DAMAGE TO THE CELLS OF THE AIRWAYS AND ARTERIOLES AS WELL AS TO THE DELICATE ALVEOLAR PARENCHYMA. USING THE COMPRESSTOME WE ARE ABLE TO OBTAIN MORE REPRODUCIBLE AND SUCCESSFUL EXPERIMENTS.” _-DR. PEREZ-ZOGHBI, TEXAS TECH UNIVERSITY _ “WITH THE COMPRESSTOME® I WAS ABLE TO PREPARE HIGH QUALITY SLICES WITH EXCELLENT PRESERVATION NEAR THE SLICE SURFACE.” _-DR. JONATHAN TING, ALLEN INSTITUTE_ “HE MODEL’S DESIGN IS ALSO SUITED FOR CUTTING SMALL OR VERY SOFT TISSUES. WE ALSO USED IT FOR PREPARING ORGANOTYPIC TISSUE CULTURES, AND IT WORKED WELL.” _-DR. YAN GU AND DR. SHAOYU GE, DEPARTMENT OF NEUROBIOLOGY, SUNY ATSTONY BROOK_
“I HAVE SUCCESSFULLY BEEN ABLE TO DO TARGETED WHOLE-CELL RECORDINGS FROM FLUORESCENTLY LABELED NEURONS IN SLICES PREPARED FROM >1 YEAR OLD MICE, WHICH IS NOT GENERALLY POSSIBLE WITH CONVENTIONAL SLICERS ANDMETHODS.”
_-DR. JONATHAN TING, ALLEN INSTITUTE_ “ELL SURVIVAL RATES WERE SIGNIFICANTLY HIGHER WHEN USING THEVF-200.”
_-DR. JIE WU, DIRECTOR OF EPILEPSY RESEARCH, BARROW NEUROLOGICALINSTITUTE_
“THE VF-300 IS MORE CONSISTENT IN GENERATING UNIFORM SLICES AND LEAVES THE STRUCTURE OF THE TISSUE/CELLS MORE INTACT THAN THE METHOD WE HAD BEEN USING. WE HAVE BEEN ABLE TO EXTEND THE AMOUNT OF TIME OVER WHICH WE CAN CUT LUNG SLICES, AND ALLOWS PRESERVATION OF THE ARCHITECTURE OF THE SLICE AND GREATER VIABILITY OF THE TISSUE.” _-DR. CYNTHIA KOZIAL-WHITE, UNIVERSITY OF PENNSYLVANIA_ “CURRENTLY, WE ARE ABLE TO ROUTINELY PERFORM (ON A DAILY BASIS) PATCH-CLAMP RECORDINGS FROM MECHANICALLY-DISSOCIATED NEURONS WITH ADHERENT BOUTONS ONLY WHEN USING THE VF-200, WHICH WAS PREVIOUSLY UNOBTAINABLE USING VIBRATING MICROTOMES PURCHASED FROM OTHER LEADINGCOMPANIES.”
_-DR. JIE WU, DIRECTOR OF EPILEPSY RESEARCH, BARROW NEUROLOGICALINSTITUTE_
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* VF 310-0Z
* VF-700-0Z
* VF-800-0Z
* Compresstome Accessories * Cryostats (COMING SOON) * Rental/Lease Program * Information & Support __ * FAQ/Troubleshooting * References & Protocols* By Experiment
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