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PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
ICD-11: 2F30.Y & XH2V57 - other specified benign neoplasm of breast and adenomyoepithelioma, benign. Malignant adenomyoepitheliomas. ICD-O: 8562/3 epithelial-myoepithelial carcinoma. ICD-11: 2C6Y & XH7TL5 - malignant neoplasmsPATHOLOGY OUTLINES
Pan T cell marker. Diagnosis of myeloid (granulocytic) sarcoma ( J Clin Pathol 2005;58:211 ) Classify subtypes of T cell lymphomas and low grade B cell lymphomas. Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J SurgPathol 2002;26:76 )
PATHOLOGY OUTLINES
CD10 and BCL6 are weaker in interfollicular tumoral cells. BCL2 (variable) Positive in 85 - 90% of follicular lymphoma grades 1 and 2. It may be negative in grade 3. False negative: mutations of the BCL2 epitope (anti-BCL2 antibody used) Follicular dendritic cell meshworksin
PATHOLOGY OUTLINES
Epidemiology. Rare, < 1% of all adult soft tissue sarcomas, 4 - 8% of pediatric non rhabdomyoblastic sarcomas. Classic type epithelioid sarcoma is more common than the proximal type epithelioid sarcoma. Classic type: Most common in adolescents and young adults, between ages 10 and 40 years; M:F = 1.9:1 ( Adv Anat Pathol 2016;23:41 )PATHOLOGY OUTLINES
Essential features. Incidence increasing due to biochemical testing. Diagnosis confirmed by a drop in parathyroid hormone (PTH) after surgical removal. Atypical parathyroid adenoma displays histology concerning for but not diagnostic of malignancy and requires clinical follow up after excision. Can be mistaken for thyroid follicularneoplasm by
PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
ICD-11: 2F30.Y & XH2V57 - other specified benign neoplasm of breast and adenomyoepithelioma, benign. Malignant adenomyoepitheliomas. ICD-O: 8562/3 epithelial-myoepithelial carcinoma. ICD-11: 2C6Y & XH7TL5 - malignant neoplasmsPATHOLOGY OUTLINES
Pan T cell marker. Diagnosis of myeloid (granulocytic) sarcoma ( J Clin Pathol 2005;58:211 ) Classify subtypes of T cell lymphomas and low grade B cell lymphomas. Differentiate pulmonary MALT lymphoma (CD20+ CD43+) from lymphoid hyperplasia (CD43 negative, Am J SurgPathol 2002;26:76 )
PATHOLOGY OUTLINES
CD10 and BCL6 are weaker in interfollicular tumoral cells. BCL2 (variable) Positive in 85 - 90% of follicular lymphoma grades 1 and 2. It may be negative in grade 3. False negative: mutations of the BCL2 epitope (anti-BCL2 antibody used) Follicular dendritic cell meshworksin
PATHOLOGY OUTLINES
Epidemiology. Rare, < 1% of all adult soft tissue sarcomas, 4 - 8% of pediatric non rhabdomyoblastic sarcomas. Classic type epithelioid sarcoma is more common than the proximal type epithelioid sarcoma. Classic type: Most common in adolescents and young adults, between ages 10 and 40 years; M:F = 1.9:1 ( Adv Anat Pathol 2016;23:41 )PATHOLOGY OUTLINES
Essential features. Incidence increasing due to biochemical testing. Diagnosis confirmed by a drop in parathyroid hormone (PTH) after surgical removal. Atypical parathyroid adenoma displays histology concerning for but not diagnostic of malignancy and requires clinical follow up after excision. Can be mistaken for thyroid follicularneoplasm by
PATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
This text is intended as a practical guide for physicians and surgeons who treat diseases of the breast, both benign and malignant. Thus, general surgeons, internists, family practitioners, gynecologists, surgical oncologists, radiation oncologists, andPATHOLOGY OUTLINES
67 year old man with squamous cell carcinoma of the prostate (Case Reports in Clin Pathol 2016;3:60) 76 year old man with renal-like clear cell carcinoma, positive for CD10 and PSA (In Vivo 2020;34:2751) 9 cases of patients ranging from 42 - 78 years with rectal adenocarcinoma (Hum Pathol 2007;38:1836) 16 prostate needle biopsies with distorted benign rectal glands that mimic prostatePATHOLOGY OUTLINES
Essential features. Merkel cell carcinoma is a highly aggressive primary cutaneous neuroendocrine carcinoma primarily affecting elderly and immunosuppressed individuals. Diagnosis requires microscopic evaluation as the clinical appearance is nonspecific and can mimic a variety of benign and malignant skin lesions.PATHOLOGY OUTLINES
A frozen section (cryosection) is a pathological laboratory technique used for rapid microscopic analysis / diagnosis of a specimen /disease
PATHOLOGY OUTLINES
Network of fibrovascular cores, but discrete papillae are not identified. Solid growth with cellular streaming and low grade, ovoid or spindled cells, resembling usual ductal hyperplasia. Cells may have endocrine features with granular eosinophilic cytoplasm and fine chromatin. May have pseudorosettes with palisading around smallvascular spaces.
WWW.PATHOLOGYOUTLINES.COM or patchy p16 and wild-type p53 . (heterogeneous staining). CER VIXPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
31 year old man with tibial tumor (Arch Pathol Lab Med 2004;128:e65) 44 year old woman with low grade tumor and invasion into skeletal muscle (J Dermatol 2007;34:561) 69 year old man with myxofibrosarcoma arising in maxillary sinus (J Maxillofac Oral Surg 2011;10:334) 72 year old man with high grade myxofibrosarcoma presenting at spermatic cord after radiotherapy for prostate cancerPATHOLOGY OUTLINES
Stomach - Early gastric carcinoma. This website is intended for pathologists and laboratory personnel but not for patients.PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
Widest expression among somatostatin receptors Expressed in a broad variety of neuroendocrine and other tumors Also expressed in normal tissues (brain, pituitary, pancreatic islet, stomach foveolar cells, duodenal glands, small and large intestine surface epithelial cells, kidney, testis, endothelium, lymphocytes, monocytes, macrophages and fibroblasts) (Exp Clin Endocrinol DiabetesPATHOLOGY OUTLINES
Classic: localized, annularly arranged pink to red nonscaly macules or papules, sometimes forming arciform to annular plaques, favoring extremities. Approximately 75% of cases ( J Am Acad Dermatol 2016;75:457 ) Generalized: macules, papules, patches, plaquesPATHOLOGY OUTLINES
Endometrioid endometrial carcinoma with clear cell or secretory change: Low grade nuclear features, associated atypical hyperplasia, estrogen receptor positive (strong, diffuse) Arias-Stella reaction : Younger age, associated pregnancy / progesteronePATHOLOGY OUTLINES
ICD-11: 2F30.Y & XH2V57 - other specified benign neoplasm of breast and adenomyoepithelioma, benign. Malignant adenomyoepitheliomas. ICD-O: 8562/3 epithelial-myoepithelial carcinoma. ICD-11: 2C6Y & XH7TL5 - malignant neoplasmsPATHOLOGY OUTLINES
Definition / general. Usually asymptomatic or pain due to pathologic fracture. Age 20 - 49 years, no gender preference. May be due to displaced growth plate. Sites: small bones of hands and feet (rare in thumb or ribs) 70% solitary; 30% multiple. Multiple enchondromas: may produce severe deformities; associated with chondrosarcomatousPATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
Widest expression among somatostatin receptors Expressed in a broad variety of neuroendocrine and other tumors Also expressed in normal tissues (brain, pituitary, pancreatic islet, stomach foveolar cells, duodenal glands, small and large intestine surface epithelial cells, kidney, testis, endothelium, lymphocytes, monocytes, macrophages and fibroblasts) (Exp Clin Endocrinol DiabetesPATHOLOGY OUTLINES
Classic: localized, annularly arranged pink to red nonscaly macules or papules, sometimes forming arciform to annular plaques, favoring extremities. Approximately 75% of cases ( J Am Acad Dermatol 2016;75:457 ) Generalized: macules, papules, patches, plaquesPATHOLOGY OUTLINES
Endometrioid endometrial carcinoma with clear cell or secretory change: Low grade nuclear features, associated atypical hyperplasia, estrogen receptor positive (strong, diffuse) Arias-Stella reaction : Younger age, associated pregnancy / progesteronePATHOLOGY OUTLINES
ICD-11: 2F30.Y & XH2V57 - other specified benign neoplasm of breast and adenomyoepithelioma, benign. Malignant adenomyoepitheliomas. ICD-O: 8562/3 epithelial-myoepithelial carcinoma. ICD-11: 2C6Y & XH7TL5 - malignant neoplasmsPATHOLOGY OUTLINES
Definition / general. Usually asymptomatic or pain due to pathologic fracture. Age 20 - 49 years, no gender preference. May be due to displaced growth plate. Sites: small bones of hands and feet (rare in thumb or ribs) 70% solitary; 30% multiple. Multiple enchondromas: may produce severe deformities; associated with chondrosarcomatousPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
This text is intended as a practical guide for physicians and surgeons who treat diseases of the breast, both benign and malignant. Thus, general surgeons, internists, family practitioners, gynecologists, surgical oncologists, radiation oncologists, andPATHOLOGY OUTLINES
Definition / general. Usually asymptomatic or pain due to pathologic fracture. Age 20 - 49 years, no gender preference. May be due to displaced growth plate. Sites: small bones of hands and feet (rare in thumb or ribs) 70% solitary; 30% multiple. Multiple enchondromas: may produce severe deformities; associated with chondrosarcomatousPATHOLOGY OUTLINES
Classic Hodgkin lymphoma (CHL) is a monoclonal lymphoid neoplasm (in most instances derived from B cells) composed of mononuclear Hodgkin and multinucleated Hodgkin Reed-Sternberg (HRS) cells residing in an infiltrate containing a variable mixture of nonneoplastic small lymphocytes, eosinophils, neutrophils, histiocytes, plasma cells, fibroblasts and collagen fibers (WHO ClassificationPATHOLOGY OUTLINES
67 year old man with squamous cell carcinoma of the prostate (Case Reports in Clin Pathol 2016;3:60) 76 year old man with renal-like clear cell carcinoma, positive for CD10 and PSA (In Vivo 2020;34:2751) 9 cases of patients ranging from 42 - 78 years with rectal adenocarcinoma (Hum Pathol 2007;38:1836) 16 prostate needle biopsies with distorted benign rectal glands that mimic prostatePATHOLOGY OUTLINES
Rarely are WHO grade III (malignant with metastatic potential) Many variants of meningiomas exist. Grade I variants. Angiomatous: 2% of all meningiomas. Vascular component should exceed 50% of total tumor area. Meningothelial cells are wrapped around small blood vessels. Also has large vessels. Mean Ki67 index is 2%. WWW.PATHOLOGYOUTLINES.COM or patchy p16 and wild-type p53 . (heterogeneous staining). CER VIXPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Essential features. Merkel cell carcinoma is a highly aggressive primary cutaneous neuroendocrine carcinoma primarily affecting elderly and immunosuppressed individuals. Diagnosis requires microscopic evaluation as the clinical appearance is nonspecific and can mimic a variety of benign and malignant skin lesions.PATHOLOGY OUTLINES
Stains & molecular markers - D2-40 (Podoplanin) Angiomyolipoma - lymphatics are prominent (Mod Pathol 2006;19:669, Hum Pathol 2009;40:374) Angiosarcoma (most, Am J Pathol 1999;154:385) Atypical vascular proliferations of breast postradiation (Cancer 2007;109:1584) Chondroid and chordoid tumors: skeletal myxoid chondrosarcoma (100%), enchondroma (96%), low gradePATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
Anatomic divisions. Uterine corpus: main portion of the uterus comprising the upper two - thirds, which houses the endometrial lined cavity. Uterine cervix: lower one - third of uterus, which attaches to vaginal canal; see Histology. Fundus: domed superior portion of uterus located superior to points of fallopian tube insertion.PATHOLOGY OUTLINES
Microscopic (histologic) description. (a) prominent foveolar hyperplasia. (b) fibromuscular replacement of the lamina propria. (c) lamina propria edema. (d) vascular dilation/congestion of superficial mucosal capillaries. (e) paucity of active and chronic inflammatory cells. Can grade each feature on 0-3 scale to provide reflux score(maximum
PATHOLOGY OUTLINES
Definition / general. Also called RCC Ma ( R enal C ell C arcinoma M arker) Mouse monoclonal antibody generated against crude microsomal fraction of proximal tubules from normal human kidney. Specific for glycoprotein in renal proximal tubular brush border. Sensitive and specific for primary renal cell carcinoma ( Am J Surg Pathol2001;25:1485
PATHOLOGY OUTLINES
Diffuse growth with fascicular, solid or focally whorled pattern of spindled or round / oval tumor cells that arrange themselves around prominent, small, thin walled submucosal blood vessels. Cells have variable cytoplasm and nuclei, indistinct cell borders, occasionally are multinucleated. Minimal atypia, no necrosis, no / rare mitoticactivity.
PATHOLOGY OUTLINES
Classic: localized, annularly arranged pink to red nonscaly macules or papules, sometimes forming arciform to annular plaques, favoring extremities. Approximately 75% of cases ( J Am Acad Dermatol 2016;75:457 ) Generalized: macules, papules, patches, plaquesPATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
Anatomic divisions. Uterine corpus: main portion of the uterus comprising the upper two - thirds, which houses the endometrial lined cavity. Uterine cervix: lower one - third of uterus, which attaches to vaginal canal; see Histology. Fundus: domed superior portion of uterus located superior to points of fallopian tube insertion.PATHOLOGY OUTLINES
Microscopic (histologic) description. (a) prominent foveolar hyperplasia. (b) fibromuscular replacement of the lamina propria. (c) lamina propria edema. (d) vascular dilation/congestion of superficial mucosal capillaries. (e) paucity of active and chronic inflammatory cells. Can grade each feature on 0-3 scale to provide reflux score(maximum
PATHOLOGY OUTLINES
Definition / general. Also called RCC Ma ( R enal C ell C arcinoma M arker) Mouse monoclonal antibody generated against crude microsomal fraction of proximal tubules from normal human kidney. Specific for glycoprotein in renal proximal tubular brush border. Sensitive and specific for primary renal cell carcinoma ( Am J Surg Pathol2001;25:1485
PATHOLOGY OUTLINES
Diffuse growth with fascicular, solid or focally whorled pattern of spindled or round / oval tumor cells that arrange themselves around prominent, small, thin walled submucosal blood vessels. Cells have variable cytoplasm and nuclei, indistinct cell borders, occasionally are multinucleated. Minimal atypia, no necrosis, no / rare mitoticactivity.
PATHOLOGY OUTLINES
Classic: localized, annularly arranged pink to red nonscaly macules or papules, sometimes forming arciform to annular plaques, favoring extremities. Approximately 75% of cases ( J Am Acad Dermatol 2016;75:457 ) Generalized: macules, papules, patches, plaquesPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
This text is intended as a practical guide for physicians and surgeons who treat diseases of the breast, both benign and malignant. Thus, general surgeons, internists, family practitioners, gynecologists, surgical oncologists, radiation oncologists, andPATHOLOGY OUTLINES
67 year old man with squamous cell carcinoma of the prostate (Case Reports in Clin Pathol 2016;3:60) 76 year old man with renal-like clear cell carcinoma, positive for CD10 and PSA (In Vivo 2020;34:2751) 9 cases of patients ranging from 42 - 78 years with rectal adenocarcinoma (Hum Pathol 2007;38:1836) 16 prostate needle biopsies with distorted benign rectal glands that mimic prostatePATHOLOGY OUTLINES
Perniosis : Painful erythematous or edematous nodules on acral skin following exposure to cold. Clinical context variable: chronic cutaneous lupus erythematosus (CCLE) without systemic disease, chilblain lupus erythematosus in the context of systemic lupus erythematosus, idiopathic perniosis and COVID-19. Vacuolar interfacechange is common.
WWW.PATHOLOGYOUTLINES.COM or patchy p16 and wild-type p53 . (heterogeneous staining). CER VIXPATHOLOGY OUTLINES
Tumors are most commonly detected as spiculated mass lesions on mammography, followed by findings of asymmetric densities and opacities. Approximately 15% of cases may be difficult to identify on imaging or may present with benign findings. Since these tumors are more commonly multicentric and bilateral, evaluation of both breastsis critical.
PATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
(a) Telangiectatic polyps with stratified squamous epithelium overlying numerous thin walled dilated vessels and fibrinous exudates in edematous mucosa, variable chronic inflammatory infiltrate or (b) gelatinous polyps with stratified squamous epithelium, edematous submucosa containing fibrin and proliferating fibroblasts, thin walled vessels present but less than telangiectatic subtypePATHOLOGY OUTLINES
10 children, 2 - 14 years old; 9 patients received chemotherapy, 3 with progressive disease; 6 patient harbored genomic alterations affecting the MAPK pathway (J Neurooncol 2016;128:293) 4 year old boy with diffuse leptomeningeal thickening; review of imaging features (J Belg Soc Radiol 2017;101:19) 7 year old boy with low grade tumor versus 9 year old boy with high grade tumor (HumPATHOLOGY OUTLINES
1 day ago · 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan48025 (USA)
PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Octamer binding transcription factor (OCT) 3/4 is essential for pluripotency and self renewal of stem cells (Wiley Interdiscip Rev Syst Biol Med 2009;1:228) 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3 ; Together with SOX2, essential for reprogramming somatic cells into pluripotent stem cells (Wiley Interdiscip Rev Syst BiolPATHOLOGY OUTLINES
Endoscopy may show scalloping or flattening of duodenal folds, fissuring over the folds and a mosaic pattern of mucosa of folds. Refractory (unclassified sprue): celiac sprue that does not respond to gluten free diet of 6 - 12 months. Note: must rule out diet with gluten contamination, microscopic colitis, bacterial overgrowth,pancreatic
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Skin, left ring finger, punch biopsy: Digital papillary adenocarcinoma (see comment) Comment: The histopathological examination shows a well circumscribed multinodular tumor within the dermis to superficial subcutis. It shows solid and cystic portions with focal papillary projections and tubular structures. Two cell layers are present; innerPATHOLOGY OUTLINES
Essential features. Uncommon benign tumor, most frequently seen in the genital tract of both sexes. In the female genital tract: uterus / fallopian tube / ovarian hilus / broad ligament. In the male genital tract: epididymis / tunica albuginea / spermatic cord / tunica vaginalis, testis and prostate. Extragenital tumors are rare: adrenalglands
PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Octamer binding transcription factor (OCT) 3/4 is essential for pluripotency and self renewal of stem cells (Wiley Interdiscip Rev Syst Biol Med 2009;1:228) 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3 ; Together with SOX2, essential for reprogramming somatic cells into pluripotent stem cells (Wiley Interdiscip Rev Syst BiolPATHOLOGY OUTLINES
Endoscopy may show scalloping or flattening of duodenal folds, fissuring over the folds and a mosaic pattern of mucosa of folds. Refractory (unclassified sprue): celiac sprue that does not respond to gluten free diet of 6 - 12 months. Note: must rule out diet with gluten contamination, microscopic colitis, bacterial overgrowth,pancreatic
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Skin, left ring finger, punch biopsy: Digital papillary adenocarcinoma (see comment) Comment: The histopathological examination shows a well circumscribed multinodular tumor within the dermis to superficial subcutis. It shows solid and cystic portions with focal papillary projections and tubular structures. Two cell layers are present; innerPATHOLOGY OUTLINES
Essential features. Uncommon benign tumor, most frequently seen in the genital tract of both sexes. In the female genital tract: uterus / fallopian tube / ovarian hilus / broad ligament. In the male genital tract: epididymis / tunica albuginea / spermatic cord / tunica vaginalis, testis and prostate. Extragenital tumors are rare: adrenalglands
PATHOLOGY OUTLINES
This text is intended as a practical guide for physicians and surgeons who treat diseases of the breast, both benign and malignant. Thus, general surgeons, internists, family practitioners, gynecologists, surgical oncologists, radiation oncologists, andPATHOLOGY OUTLINES
Pathology Outlines Job Search. CONNECTICUT, NEW HAVEN (USA). Yale School of Medicine is seeking an academically oriented, board certified surgical pathologist to serve as Director of Breast Service.A record of demonstrated academic productivity and clinical excellence in diagnostic pathology is required.PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
ICD-11: 2F30.Y & XH2V57 - other specified benign neoplasm of breast and adenomyoepithelioma, benign. Malignant adenomyoepitheliomas. ICD-O: 8562/3 epithelial-myoepithelial carcinoma. ICD-11: 2C6Y & XH7TL5 - malignant neoplasms of breast and adenomyoepitheliomaPATHOLOGY OUTLINES
Rarely are WHO grade III (malignant with metastatic potential) Many variants of meningiomas exist. Grade I variants. Angiomatous: 2% of all meningiomas. Vascular component should exceed 50% of total tumor area. Meningothelial cells are wrapped around small blood vessels. Also has large vessels. Mean Ki67 index is 2%.PATHOLOGY OUTLINES
41, 55 and 68 year old men with clear cell RCC metastasis that significantly decreased in size or resolved with no surgical or other types of treatment (Case Rep Oncol 2020;13:1285) 52 year old man with a metastatic clear cell RCC to the forearm without an identifiable primary renal mass (Urol Case Rep 2019;27:100989) 63 year old man with 15 cm clear cell RCC with syncytial giant cells (ArchPATHOLOGY OUTLINES
Merkel cell carcinoma is a highly aggressive primary cutaneous neuroendocrine carcinoma primarily affecting elderly and immunosuppressed individuals. Diagnosis requires microscopic evaluation as the clinical appearance is nonspecific and can mimic a variety of benign and malignant skin lesions. There is emerging evidence of distinct Merkel cellPATHOLOGY OUTLINES
A primary salivary gland or minor salivary gland of upper aerodigestive tract carcinoma characterized by its biphasic ductal and myoepithelial differentiation, tubular / cribriform / solid architecture (Head Neck 2017;39:456) More common (60% of all tumors) in minor salivary gland, especially those in oral cavity but may also occur in sinonasal tract, nasopharynx, oropharynx andPATHOLOGY OUTLINES
Definition / general. Benign spindle cell tumor of mammary stroma composed of fibroblasts and myofibroblasts with recurrent monoallelic loss of 13q14 region including RB1. First recognized in 1981 and described by Wagotz in 1987 ( Am J Surg Pathol 1987;11:493 ) When present in mesenchymal soft tissue, termed mammary typemyofibroblastoma.
PATHOLOGY OUTLINES
Differentiated vulvar intraepithelial neoplasia (dVIN) is the putative precursor lesion of HPV independent vulvar squamous cell carcinoma. Subtypes: differentiated exophytic vulvar intraepithelial lesion (DEVIL) and vulvar acanthosis with altered differentiation (VAAD) with currently unknown prognosis but potential to develop carcinoma.PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Octamer binding transcription factor (OCT) 3/4 is essential for pluripotency and self renewal of stem cells (Wiley Interdiscip Rev Syst Biol Med 2009;1:228) 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3 ; Together with SOX2, essential for reprogramming somatic cells into pluripotent stem cells (Wiley Interdiscip Rev Syst BiolPATHOLOGY OUTLINES
Endoscopy may show scalloping or flattening of duodenal folds, fissuring over the folds and a mosaic pattern of mucosa of folds. Refractory (unclassified sprue): celiac sprue that does not respond to gluten free diet of 6 - 12 months. Note: must rule out diet with gluten contamination, microscopic colitis, bacterial overgrowth,pancreatic
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Skin, left ring finger, punch biopsy: Digital papillary adenocarcinoma (see comment) Comment: The histopathological examination shows a well circumscribed multinodular tumor within the dermis to superficial subcutis. It shows solid and cystic portions with focal papillary projections and tubular structures. Two cell layers are present; innerPATHOLOGY OUTLINES
Essential features. Uncommon benign tumor, most frequently seen in the genital tract of both sexes. In the female genital tract: uterus / fallopian tube / ovarian hilus / broad ligament. In the male genital tract: epididymis / tunica albuginea / spermatic cord / tunica vaginalis, testis and prostate. Extragenital tumors are rare: adrenalglands
PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Octamer binding transcription factor (OCT) 3/4 is essential for pluripotency and self renewal of stem cells (Wiley Interdiscip Rev Syst Biol Med 2009;1:228) 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3 ; Together with SOX2, essential for reprogramming somatic cells into pluripotent stem cells (Wiley Interdiscip Rev Syst BiolPATHOLOGY OUTLINES
Endoscopy may show scalloping or flattening of duodenal folds, fissuring over the folds and a mosaic pattern of mucosa of folds. Refractory (unclassified sprue): celiac sprue that does not respond to gluten free diet of 6 - 12 months. Note: must rule out diet with gluten contamination, microscopic colitis, bacterial overgrowth,pancreatic
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Skin, left ring finger, punch biopsy: Digital papillary adenocarcinoma (see comment) Comment: The histopathological examination shows a well circumscribed multinodular tumor within the dermis to superficial subcutis. It shows solid and cystic portions with focal papillary projections and tubular structures. Two cell layers are present; innerPATHOLOGY OUTLINES
Essential features. Uncommon benign tumor, most frequently seen in the genital tract of both sexes. In the female genital tract: uterus / fallopian tube / ovarian hilus / broad ligament. In the male genital tract: epididymis / tunica albuginea / spermatic cord / tunica vaginalis, testis and prostate. Extragenital tumors are rare: adrenalglands
PATHOLOGY OUTLINES
Pathology Outlines Job Search. CONNECTICUT, NEW HAVEN (USA). Yale School of Medicine is seeking an academically oriented, board certified surgical pathologist to serve as Director of Breast Service.A record of demonstrated academic productivity and clinical excellence in diagnostic pathology is required.PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Rarely are WHO grade III (malignant with metastatic potential) Many variants of meningiomas exist. Grade I variants. Angiomatous: 2% of all meningiomas. Vascular component should exceed 50% of total tumor area. Meningothelial cells are wrapped around small blood vessels. Also has large vessels. Mean Ki67 index is 2%.PATHOLOGY OUTLINES
ICD-11: 2F30.Y & XH2V57 - other specified benign neoplasm of breast and adenomyoepithelioma, benign. Malignant adenomyoepitheliomas. ICD-O: 8562/3 epithelial-myoepithelial carcinoma. ICD-11: 2C6Y & XH7TL5 - malignant neoplasms of breast and adenomyoepitheliomaPATHOLOGY OUTLINES
41, 55 and 68 year old men with clear cell RCC metastasis that significantly decreased in size or resolved with no surgical or other types of treatment (Case Rep Oncol 2020;13:1285) 52 year old man with a metastatic clear cell RCC to the forearm without an identifiable primary renal mass (Urol Case Rep 2019;27:100989) 63 year old man with 15 cm clear cell RCC with syncytial giant cells (ArchPATHOLOGY OUTLINES
Merkel cell carcinoma is a highly aggressive primary cutaneous neuroendocrine carcinoma primarily affecting elderly and immunosuppressed individuals. Diagnosis requires microscopic evaluation as the clinical appearance is nonspecific and can mimic a variety of benign and malignant skin lesions. There is emerging evidence of distinct Merkel cellPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Benign spindle cell tumor of mammary stroma composed of fibroblasts and myofibroblasts with recurrent monoallelic loss of 13q14 region including RB1. First recognized in 1981 and described by Wagotz in 1987 ( Am J Surg Pathol 1987;11:493 ) When present in mesenchymal soft tissue, termed mammary typemyofibroblastoma.
PATHOLOGY OUTLINES
Differentiated vulvar intraepithelial neoplasia (dVIN) is the putative precursor lesion of HPV independent vulvar squamous cell carcinoma. Subtypes: differentiated exophytic vulvar intraepithelial lesion (DEVIL) and vulvar acanthosis with altered differentiation (VAAD) with currently unknown prognosis but potential to develop carcinoma.PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Octamer binding transcription factor (OCT) 3/4 is essential for pluripotency and self renewal of stem cells (Wiley Interdiscip Rev Syst Biol Med 2009;1:228) 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3 ; Together with SOX2, essential for reprogramming somatic cells into pluripotent stem cells (Wiley Interdiscip Rev Syst BiolPATHOLOGY OUTLINES
Endoscopy may show scalloping or flattening of duodenal folds, fissuring over the folds and a mosaic pattern of mucosa of folds. Refractory (unclassified sprue): celiac sprue that does not respond to gluten free diet of 6 - 12 months. Note: must rule out diet with gluten contamination, microscopic colitis, bacterial overgrowth,pancreatic
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Skin, left ring finger, punch biopsy: Digital papillary adenocarcinoma (see comment) Comment: The histopathological examination shows a well circumscribed multinodular tumor within the dermis to superficial subcutis. It shows solid and cystic portions with focal papillary projections and tubular structures. Two cell layers are present; innerPATHOLOGY OUTLINES
Essential features. Uncommon benign tumor, most frequently seen in the genital tract of both sexes. In the female genital tract: uterus / fallopian tube / ovarian hilus / broad ligament. In the male genital tract: epididymis / tunica albuginea / spermatic cord / tunica vaginalis, testis and prostate. Extragenital tumors are rare: adrenalglands
PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Octamer binding transcription factor (OCT) 3/4 is essential for pluripotency and self renewal of stem cells (Wiley Interdiscip Rev Syst Biol Med 2009;1:228) 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3 ; Together with SOX2, essential for reprogramming somatic cells into pluripotent stem cells (Wiley Interdiscip Rev Syst BiolPATHOLOGY OUTLINES
Endoscopy may show scalloping or flattening of duodenal folds, fissuring over the folds and a mosaic pattern of mucosa of folds. Refractory (unclassified sprue): celiac sprue that does not respond to gluten free diet of 6 - 12 months. Note: must rule out diet with gluten contamination, microscopic colitis, bacterial overgrowth,pancreatic
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Skin, left ring finger, punch biopsy: Digital papillary adenocarcinoma (see comment) Comment: The histopathological examination shows a well circumscribed multinodular tumor within the dermis to superficial subcutis. It shows solid and cystic portions with focal papillary projections and tubular structures. Two cell layers are present; innerPATHOLOGY OUTLINES
Essential features. Uncommon benign tumor, most frequently seen in the genital tract of both sexes. In the female genital tract: uterus / fallopian tube / ovarian hilus / broad ligament. In the male genital tract: epididymis / tunica albuginea / spermatic cord / tunica vaginalis, testis and prostate. Extragenital tumors are rare: adrenalglands
PATHOLOGY OUTLINES
Pathology Outlines Job Search. CONNECTICUT, NEW HAVEN (USA). Yale School of Medicine is seeking an academically oriented, board certified surgical pathologist to serve as Director of Breast Service.A record of demonstrated academic productivity and clinical excellence in diagnostic pathology is required.PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Rarely are WHO grade III (malignant with metastatic potential) Many variants of meningiomas exist. Grade I variants. Angiomatous: 2% of all meningiomas. Vascular component should exceed 50% of total tumor area. Meningothelial cells are wrapped around small blood vessels. Also has large vessels. Mean Ki67 index is 2%.PATHOLOGY OUTLINES
ICD-11: 2F30.Y & XH2V57 - other specified benign neoplasm of breast and adenomyoepithelioma, benign. Malignant adenomyoepitheliomas. ICD-O: 8562/3 epithelial-myoepithelial carcinoma. ICD-11: 2C6Y & XH7TL5 - malignant neoplasms of breast and adenomyoepitheliomaPATHOLOGY OUTLINES
41, 55 and 68 year old men with clear cell RCC metastasis that significantly decreased in size or resolved with no surgical or other types of treatment (Case Rep Oncol 2020;13:1285) 52 year old man with a metastatic clear cell RCC to the forearm without an identifiable primary renal mass (Urol Case Rep 2019;27:100989) 63 year old man with 15 cm clear cell RCC with syncytial giant cells (ArchPATHOLOGY OUTLINES
Merkel cell carcinoma is a highly aggressive primary cutaneous neuroendocrine carcinoma primarily affecting elderly and immunosuppressed individuals. Diagnosis requires microscopic evaluation as the clinical appearance is nonspecific and can mimic a variety of benign and malignant skin lesions. There is emerging evidence of distinct Merkel cellPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Benign spindle cell tumor of mammary stroma composed of fibroblasts and myofibroblasts with recurrent monoallelic loss of 13q14 region including RB1. First recognized in 1981 and described by Wagotz in 1987 ( Am J Surg Pathol 1987;11:493 ) When present in mesenchymal soft tissue, termed mammary typemyofibroblastoma.
PATHOLOGY OUTLINES
Differentiated vulvar intraepithelial neoplasia (dVIN) is the putative precursor lesion of HPV independent vulvar squamous cell carcinoma. Subtypes: differentiated exophytic vulvar intraepithelial lesion (DEVIL) and vulvar acanthosis with altered differentiation (VAAD) with currently unknown prognosis but potential to develop carcinoma.PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Octamer binding transcription factor (OCT) 3/4 is essential for pluripotency and self renewal of stem cells (Wiley Interdiscip Rev Syst Biol Med 2009;1:228) 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3 ; Together with SOX2, essential for reprogramming somatic cells into pluripotent stem cells (Wiley Interdiscip Rev Syst BiolPATHOLOGY OUTLINES
Endoscopy may show scalloping or flattening of duodenal folds, fissuring over the folds and a mosaic pattern of mucosa of folds. Refractory (unclassified sprue): celiac sprue that does not respond to gluten free diet of 6 - 12 months. Note: must rule out diet with gluten contamination, microscopic colitis, bacterial overgrowth,pancreatic
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Skin, left ring finger, punch biopsy: Digital papillary adenocarcinoma (see comment) Comment: The histopathological examination shows a well circumscribed multinodular tumor within the dermis to superficial subcutis. It shows solid and cystic portions with focal papillary projections and tubular structures. Two cell layers are present; innerPATHOLOGY OUTLINES
Essential features. Uncommon benign tumor, most frequently seen in the genital tract of both sexes. In the female genital tract: uterus / fallopian tube / ovarian hilus / broad ligament. In the male genital tract: epididymis / tunica albuginea / spermatic cord / tunica vaginalis, testis and prostate. Extragenital tumors are rare: adrenalglands
PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Octamer binding transcription factor (OCT) 3/4 is essential for pluripotency and self renewal of stem cells (Wiley Interdiscip Rev Syst Biol Med 2009;1:228) 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3 ; Together with SOX2, essential for reprogramming somatic cells into pluripotent stem cells (Wiley Interdiscip Rev Syst BiolPATHOLOGY OUTLINES
Endoscopy may show scalloping or flattening of duodenal folds, fissuring over the folds and a mosaic pattern of mucosa of folds. Refractory (unclassified sprue): celiac sprue that does not respond to gluten free diet of 6 - 12 months. Note: must rule out diet with gluten contamination, microscopic colitis, bacterial overgrowth,pancreatic
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Skin, left ring finger, punch biopsy: Digital papillary adenocarcinoma (see comment) Comment: The histopathological examination shows a well circumscribed multinodular tumor within the dermis to superficial subcutis. It shows solid and cystic portions with focal papillary projections and tubular structures. Two cell layers are present; innerPATHOLOGY OUTLINES
Essential features. Uncommon benign tumor, most frequently seen in the genital tract of both sexes. In the female genital tract: uterus / fallopian tube / ovarian hilus / broad ligament. In the male genital tract: epididymis / tunica albuginea / spermatic cord / tunica vaginalis, testis and prostate. Extragenital tumors are rare: adrenalglands
PATHOLOGY OUTLINES
Pathology Outlines Job Search. CONNECTICUT, NEW HAVEN (USA). Yale School of Medicine is seeking an academically oriented, board certified surgical pathologist to serve as Director of Breast Service.A record of demonstrated academic productivity and clinical excellence in diagnostic pathology is required.PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Rarely are WHO grade III (malignant with metastatic potential) Many variants of meningiomas exist. Grade I variants. Angiomatous: 2% of all meningiomas. Vascular component should exceed 50% of total tumor area. Meningothelial cells are wrapped around small blood vessels. Also has large vessels. Mean Ki67 index is 2%.PATHOLOGY OUTLINES
ICD-11: 2F30.Y & XH2V57 - other specified benign neoplasm of breast and adenomyoepithelioma, benign. Malignant adenomyoepitheliomas. ICD-O: 8562/3 epithelial-myoepithelial carcinoma. ICD-11: 2C6Y & XH7TL5 - malignant neoplasms of breast and adenomyoepitheliomaPATHOLOGY OUTLINES
41, 55 and 68 year old men with clear cell RCC metastasis that significantly decreased in size or resolved with no surgical or other types of treatment (Case Rep Oncol 2020;13:1285) 52 year old man with a metastatic clear cell RCC to the forearm without an identifiable primary renal mass (Urol Case Rep 2019;27:100989) 63 year old man with 15 cm clear cell RCC with syncytial giant cells (ArchPATHOLOGY OUTLINES
Merkel cell carcinoma is a highly aggressive primary cutaneous neuroendocrine carcinoma primarily affecting elderly and immunosuppressed individuals. Diagnosis requires microscopic evaluation as the clinical appearance is nonspecific and can mimic a variety of benign and malignant skin lesions. There is emerging evidence of distinct Merkel cellPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Benign spindle cell tumor of mammary stroma composed of fibroblasts and myofibroblasts with recurrent monoallelic loss of 13q14 region including RB1. First recognized in 1981 and described by Wagotz in 1987 ( Am J Surg Pathol 1987;11:493 ) When present in mesenchymal soft tissue, termed mammary typemyofibroblastoma.
PATHOLOGY OUTLINES
Differentiated vulvar intraepithelial neoplasia (dVIN) is the putative precursor lesion of HPV independent vulvar squamous cell carcinoma. Subtypes: differentiated exophytic vulvar intraepithelial lesion (DEVIL) and vulvar acanthosis with altered differentiation (VAAD) with currently unknown prognosis but potential to develop carcinoma.PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Octamer binding transcription factor (OCT) 3/4 is essential for pluripotency and self renewal of stem cells (Wiley Interdiscip Rev Syst Biol Med 2009;1:228) 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3 ; Together with SOX2, essential for reprogramming somatic cells into pluripotent stem cells (Wiley Interdiscip Rev Syst BiolPATHOLOGY OUTLINES
Endoscopy may show scalloping or flattening of duodenal folds, fissuring over the folds and a mosaic pattern of mucosa of folds. Refractory (unclassified sprue): celiac sprue that does not respond to gluten free diet of 6 - 12 months. Note: must rule out diet with gluten contamination, microscopic colitis, bacterial overgrowth,pancreatic
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Skin, left ring finger, punch biopsy: Digital papillary adenocarcinoma (see comment) Comment: The histopathological examination shows a well circumscribed multinodular tumor within the dermis to superficial subcutis. It shows solid and cystic portions with focal papillary projections and tubular structures. Two cell layers are present; innerPATHOLOGY OUTLINES
Essential features. Uncommon benign tumor, most frequently seen in the genital tract of both sexes. In the female genital tract: uterus / fallopian tube / ovarian hilus / broad ligament. In the male genital tract: epididymis / tunica albuginea / spermatic cord / tunica vaginalis, testis and prostate. Extragenital tumors are rare: adrenalglands
PATHOLOGY OUTLINES
PathologyOutlines.com, free, updated outline surgical pathology clinical pathology pathologist jobs, conferences, fellowships, booksPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Octamer binding transcription factor (OCT) 3/4 is essential for pluripotency and self renewal of stem cells (Wiley Interdiscip Rev Syst Biol Med 2009;1:228) 18 kDa domain transcription factor encoded by POU5F1 gene (POU domain, class 5, transcription factor 1) at 6p21.3 ; Together with SOX2, essential for reprogramming somatic cells into pluripotent stem cells (Wiley Interdiscip Rev Syst BiolPATHOLOGY OUTLINES
Endoscopy may show scalloping or flattening of duodenal folds, fissuring over the folds and a mosaic pattern of mucosa of folds. Refractory (unclassified sprue): celiac sprue that does not respond to gluten free diet of 6 - 12 months. Note: must rule out diet with gluten contamination, microscopic colitis, bacterial overgrowth,pancreatic
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Skin, left ring finger, punch biopsy: Digital papillary adenocarcinoma (see comment) Comment: The histopathological examination shows a well circumscribed multinodular tumor within the dermis to superficial subcutis. It shows solid and cystic portions with focal papillary projections and tubular structures. Two cell layers are present; innerPATHOLOGY OUTLINES
Essential features. Uncommon benign tumor, most frequently seen in the genital tract of both sexes. In the female genital tract: uterus / fallopian tube / ovarian hilus / broad ligament. In the male genital tract: epididymis / tunica albuginea / spermatic cord / tunica vaginalis, testis and prostate. Extragenital tumors are rare: adrenalglands
PATHOLOGY OUTLINES
Pathology Outlines Job Search. CONNECTICUT, NEW HAVEN (USA). Yale School of Medicine is seeking an academically oriented, board certified surgical pathologist to serve as Director of Breast Service.A record of demonstrated academic productivity and clinical excellence in diagnostic pathology is required.PATHOLOGY OUTLINES
Definition / general. Transcriptional regulator ERG is a protein encoded by ERG ( ETS family transcription factor ERG), which is located at 21q22. Anti-ERG monoclonal antibodies to the N- or C- terminus are available with a slightly different specificity. Highly sensitive immunohistochemical marker for vascular differentiation andcartilaginous
PATHOLOGY OUTLINES
Antibody to cell membrane glycoproteins expressed on healthy epithelia and in various carcinomas Also known as epithelial cell adhesion molecule, BerEp4 (Ber-EP4, J Clin Pathol 1990;43:213), MOC31 (MOC-31, Acta Neuropathol 1991;83:46), CD326, TACSTD1 protein MOC31 and BerEP4 are both anti-EpCAM antibodies, MOC31 appears to be superior (Appl Immunohistochem Mol MorpholPATHOLOGY OUTLINES
Rarely are WHO grade III (malignant with metastatic potential) Many variants of meningiomas exist. Grade I variants. Angiomatous: 2% of all meningiomas. Vascular component should exceed 50% of total tumor area. Meningothelial cells are wrapped around small blood vessels. Also has large vessels. Mean Ki67 index is 2%.PATHOLOGY OUTLINES
ICD-11: 2F30.Y & XH2V57 - other specified benign neoplasm of breast and adenomyoepithelioma, benign. Malignant adenomyoepitheliomas. ICD-O: 8562/3 epithelial-myoepithelial carcinoma. ICD-11: 2C6Y & XH7TL5 - malignant neoplasms of breast and adenomyoepitheliomaPATHOLOGY OUTLINES
41, 55 and 68 year old men with clear cell RCC metastasis that significantly decreased in size or resolved with no surgical or other types of treatment (Case Rep Oncol 2020;13:1285) 52 year old man with a metastatic clear cell RCC to the forearm without an identifiable primary renal mass (Urol Case Rep 2019;27:100989) 63 year old man with 15 cm clear cell RCC with syncytial giant cells (ArchPATHOLOGY OUTLINES
Merkel cell carcinoma is a highly aggressive primary cutaneous neuroendocrine carcinoma primarily affecting elderly and immunosuppressed individuals. Diagnosis requires microscopic evaluation as the clinical appearance is nonspecific and can mimic a variety of benign and malignant skin lesions. There is emerging evidence of distinct Merkel cellPATHOLOGY OUTLINES
30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA)PATHOLOGY OUTLINES
Definition / general. Benign spindle cell tumor of mammary stroma composed of fibroblasts and myofibroblasts with recurrent monoallelic loss of 13q14 region including RB1. First recognized in 1981 and described by Wagotz in 1987 ( Am J Surg Pathol 1987;11:493 ) When present in mesenchymal soft tissue, termed mammary typemyofibroblastoma.
PATHOLOGY OUTLINES
Differentiated vulvar intraepithelial neoplasia (dVIN) is the putative precursor lesion of HPV independent vulvar squamous cell carcinoma. Subtypes: differentiated exophytic vulvar intraepithelial lesion (DEVIL) and vulvar acanthosis with altered differentiation (VAAD) with currently unknown prognosis but potential to develop carcinoma.* Authors
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