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OUR PORTFOLIO
Track Record of Success At any point in time, the InCube team is working on several innovations that have the potential to positively impact the lives of millions of patients and disrupt their respective markets. Some are research projects and others are companies on the path to commercialization. Learn more about our work by clicking OUR STORY - INCUBE LABS Our Innovation Timeline At any given time, we are working on several research projects across a range of disciplines and therapeutic areas. This work can span months to years. Our projects are heavily vetted and only those that meet our scientific and business criteria areformed into a
ADVISORS - INCUBE LABS Our Advisory Board includes thought leaders, industry experts and executives with diverse and deep experience across a range of disciplines and industries – from medicine and pharmacology to medical devices and regulatory affairs. Our Advisors provide invaluable perspectives and insights on our research projects and our companies, helping inform and shape our strategy and futureCAREERS WITH INCUBE
Join Our Team Our multi-disciplinary team is focused on solving big, unmet clinical needs across a range of therapeutic areas. We are looking for experienced team members that will thrive in our dynamic and collaborative environment. If you feel you are fit for our company, we’d love to hear from you. LOCATIONS - INCUBE LABS Our Locations Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. HOME - INCUBE LABSWHO WE AREWHAT WE DOPORTFOLIONEWSCAREERSCONTACT US Urology . Overactive bladder affects millions of patients and is a growing problem with our aging population. In addition, neurogenic bladder can lead to a number of urinary conditions in people who lack bladder control due to brain, spinal cord or nerve problems.OUR PORTFOLIO
Track Record of Success At any point in time, the InCube team is working on several innovations that have the potential to positively impact the lives of millions of patients and disrupt their respective markets. Some are research projects and others are companies on the path to commercialization. Learn more about our work by clicking OUR STORY - INCUBE LABS Our Innovation Timeline At any given time, we are working on several research projects across a range of disciplines and therapeutic areas. This work can span months to years. Our projects are heavily vetted and only those that meet our scientific and business criteria areformed into a
ADVISORS - INCUBE LABS Our Advisory Board includes thought leaders, industry experts and executives with diverse and deep experience across a range of disciplines and industries – from medicine and pharmacology to medical devices and regulatory affairs. Our Advisors provide invaluable perspectives and insights on our research projects and our companies, helping inform and shape our strategy and futureCAREERS WITH INCUBE
Join Our Team Our multi-disciplinary team is focused on solving big, unmet clinical needs across a range of therapeutic areas. We are looking for experienced team members that will thrive in our dynamic and collaborative environment. If you feel you are fit for our company, we’d love to hear from you. LOCATIONS - INCUBE LABS Our Locations Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. WHO WE ARE - INCUBE LABS Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials.OUR NETWORK
Making a difference together We have deep experience in developing and commercializing innovations from product development and manufacturing to fundraising, clinical planning and regulatory submissions. We have access to knowledge, expertise and resources that allow us to efficiently build our company and execute. LOCATIONS - INCUBE LABS Our Locations Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. CONTACT US - INCUBE LABS Get in touch We are excited about our companies and their potential to improve the lives of millions of patients. If you are interested in learning more about us and our portfolio companies, please reach out. Whether you are a potential investor, collaboration partner, media contact or potential employee, we want to hear from you! ABOUT MIR - INCUBE LABS Mir Imran Mir’s passion for improving healthcare started at a young age. Early in his career, Mir spent a summer working at The Matheney School, which specialized in treating children with cerebral palsy. While there, Mir invented a device that translated facial expressions into speech, allowing those children to communicate. It was a profoundexample
OUR CHIEF INNOVATOR
Mir Imran Mir’s passion is identifying, understanding and solving poorly or unmet clinical needs, which has led to his prolific track record of building companies. Mir is motivated by his desire to positively impact the lives of millions of patients, and he has become one of the leading inventors and entrepreneurs in the field.FE3 MEDICAL
Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia, making it
NEUROLINK - INCUBE LABS Neurolink is an early stage company developing a novel therapy for the treatment of epilepsy. Nearly three million Americans suffer from epilepsy, a neurological condition characterized by seizures. One of the most common neurological diseases, epilepsy affects approximately 1% of the population – 1 in 26 people will have epilepsy in theirlifetime.
WELCOME, AUTHOR AT INCUBE LABS Follow Us. © 2019 InCube Labs. All Rights Reserved.PHIL MORGAN
Phil Morgan brings more than 25 years of pharmaceutical research and development experience to InCube Labs and has extensive experience in drug development and the regulatory approval process. He was the pre-clinical pharmacology expert for several drugs including Wellbutrin SR and Zyban. Prior to joining InCube Labs, Phil co-founded several successful life science companies and HOME - INCUBE LABSWHO WE AREWHAT WE DOPORTFOLIONEWSCAREERSCONTACT US Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia
OUR PORTFOLIO
Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia
LOCATIONS - INCUBE LABS Our Locations Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. OUR STORY - INCUBE LABS Our Innovation Timeline At any given time, we are working on several research projects across a range of disciplines and therapeutic areas. This work can span months to years. Our projects are heavily vetted and only those that meet our scientific and business criteria areformed into a
ADVISORS - INCUBE LABS Peter Barton Hutt is a Partner specializing in food and drug law in the Washington, D.C. law firm of ovington & Burling. He served as Chief Counsel for the FDA from 1971-1975 and is the co-author of a casebook used to teach food and drug law throughout the country. Mr. Hutt currently serves on the Boards of Directors of several public andCAREERS WITH INCUBE
Milpitas, CA. plus. Job Description. The office manager position is responsible for overall office activities, including the reception area, mail, check distribution, ordering supplies, maintaining inventory, record keeping and assisting with facilities. Also responsible for directing and coordinating office services and relatedactivities.
LEADERSHIP - INCUBE LABS We have expertise across a range of disciplines: pharmacology and physiology, protein and polymer chemistry, tissue engineering, mechanical engineering and material science, electronics and software, industrial design, clinical development and manufacturing. Our leadership team also has deep experience in company building and commercializing innovations. INTRAPACE - INCUBE LABS IntraPace is developing an innovative product platform utilizing gastric stimulation for the treatment of obesity. IntraPace was founded in 2001 to address an unmet need in weight loss surgery by developing a gentler solution for weight loss that incorporates essential components of behavior therapy. The abiliti system is intended to enable patients to achieve and SACRAMED - INCUBE LABS SacraMed is a medical technology company focused on the development of a neuromodulation system for the treatment of Overactive bladder (OAB). OAB is a bladder disorder that results in an abnormal urge to urinate, with or without urinary incontinence. It can occur at any age, but is most common in the elderly population. Approximately 1KATHLEEN A. BUTO
Kathy Buto is currently an independent consultant, focused on health policy issues. She serves as a Commissioner, Medicare Payment Advisory Commission, which advises Congress and the Administration on Medicare payment to health plans and providers. Ms. Buto retired in March 2013 as Vice President, Global Health Policy, Government Affairs, at Johnson & Johnson, where she HOME - INCUBE LABSWHO WE AREWHAT WE DOPORTFOLIONEWSCAREERSCONTACT US Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia
OUR PORTFOLIO
Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia
LOCATIONS - INCUBE LABS Our Locations Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. OUR STORY - INCUBE LABS Our Innovation Timeline At any given time, we are working on several research projects across a range of disciplines and therapeutic areas. This work can span months to years. Our projects are heavily vetted and only those that meet our scientific and business criteria areformed into a
ADVISORS - INCUBE LABS Peter Barton Hutt is a Partner specializing in food and drug law in the Washington, D.C. law firm of ovington & Burling. He served as Chief Counsel for the FDA from 1971-1975 and is the co-author of a casebook used to teach food and drug law throughout the country. Mr. Hutt currently serves on the Boards of Directors of several public andCAREERS WITH INCUBE
Milpitas, CA. plus. Job Description. The office manager position is responsible for overall office activities, including the reception area, mail, check distribution, ordering supplies, maintaining inventory, record keeping and assisting with facilities. Also responsible for directing and coordinating office services and relatedactivities.
LEADERSHIP - INCUBE LABS We have expertise across a range of disciplines: pharmacology and physiology, protein and polymer chemistry, tissue engineering, mechanical engineering and material science, electronics and software, industrial design, clinical development and manufacturing. Our leadership team also has deep experience in company building and commercializing innovations. INTRAPACE - INCUBE LABS IntraPace is developing an innovative product platform utilizing gastric stimulation for the treatment of obesity. IntraPace was founded in 2001 to address an unmet need in weight loss surgery by developing a gentler solution for weight loss that incorporates essential components of behavior therapy. The abiliti system is intended to enable patients to achieve and SACRAMED - INCUBE LABS SacraMed is a medical technology company focused on the development of a neuromodulation system for the treatment of Overactive bladder (OAB). OAB is a bladder disorder that results in an abnormal urge to urinate, with or without urinary incontinence. It can occur at any age, but is most common in the elderly population. Approximately 1KATHLEEN A. BUTO
Kathy Buto is currently an independent consultant, focused on health policy issues. She serves as a Commissioner, Medicare Payment Advisory Commission, which advises Congress and the Administration on Medicare payment to health plans and providers. Ms. Buto retired in March 2013 as Vice President, Global Health Policy, Government Affairs, at Johnson & Johnson, where sheOUR NETWORK
Modulus is ISO 9001:2008 and ISO 13485:2003 certified for Class III medical devices. Modulus is co-located with InCube Labs at our Milpitas facility. Modulus assists InCube portfolio companies with prototyping through full scale production. Modulus also works with outside companies on their manufacturing needs. The company was established in 1972. WHO WE ARE - INCUBE LABS Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. LOCATIONS - INCUBE LABS Our Locations Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. CONTACT US - INCUBE LABS Get in touch We are excited about our companies and their potential to improve the lives of millions of patients. If you are interested in learning more about us and our portfolio companies, please reach out. Whether you are a potential investor, collaboration partner, media contact or potential employee, we want to hear from you!OUR CHIEF INNOVATOR
Mir Imran Mir’s passion is identifying, understanding and solving poorly or unmet clinical needs, which has led to his prolific track record of building companies. Mir is motivated by his desire to positively impact the lives of millions of patients, and he has become one of the leading inventors and entrepreneurs in the field. ABOUT MIR - INCUBE LABS Mir Imran Mir’s passion for improving healthcare started at a young age. Early in his career, Mir spent a summer working at The Matheney School, which specialized in treating children with cerebral palsy. While there, Mir invented a device that translated facial expressions into speech, allowing those children to communicate. It was a profoundexample
FE3 MEDICAL
Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia, making it
LEAD BY VISIONARIES
Angela brings more than fifteen years of experience in engineering and eight years of experience in the legal profession to InCube. Angela has experience in patent prosecution and litigation across various technologies, such as medical devices and systems, robots and robotic systems, optics, signal processing and circuitry, wireless power transfer devices and systems, and control systems, toRANI - INCUBE LABS
The concept for Rani was developed by Mir Imran, a prolific medical inventor and entrepreneur who has founded more than twenty life sciences companies. Rani was established as a company in 2012 after several years as a research project within InCube Labs, Mir’s multi-disciplinary life sciences lab focused on developing and commercializing breakthrough innovations.PHIL MORGAN
Phil Morgan brings more than 25 years of pharmaceutical research and development experience to InCube Labs and has extensive experience in drug development and the regulatory approval process. He was the pre-clinical pharmacology expert for several drugs including Wellbutrin SR and Zyban. Prior to joining InCube Labs, Phil co-founded several successful life science companies and HOME - INCUBE LABSWHO WE AREWHAT WE DOPORTFOLIONEWSCAREERSCONTACT US Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia
OUR PORTFOLIO
Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia
WHO WE ARE - INCUBE LABS Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. OUR STORY - INCUBE LABSINCUBE LABS ADDRESSINCUBE LABS CA Our Innovation Timeline At any given time, we are working on several research projects across a range of disciplines and therapeutic areas. This work can span months to years. Our projects are heavily vetted and only those that meet our scientific and business criteria areformed into a
LOCATIONS - INCUBE LABSINCUBE FZCOINCUBE LABS LLCINCUBE MOBILITYINCUBEVENTURES
Our Locations Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials.NEWS AND ARTICLES
InCube in the News. Read more about InCube, Mir and our portfolio companies in the news. InCube portfolio company, Rani Therapeutics, is garnering attention for its novel approach to the oral delivery of biologics, considered the Holy Grail in Drug Delivery.featured-prev-blue.
ADVISORS - INCUBE LABSINCUBE LABS ADDRESSINCUBE LABS CA Peter Barton Hutt is a Partner specializing in food and drug law in the Washington, D.C. law firm of ovington & Burling. He served as Chief Counsel for the FDA from 1971-1975 and is the co-author of a casebook used to teach food and drug law throughout the country. Mr. Hutt currently serves on the Boards of Directors of several public andCAREERS WITH INCUBE
Milpitas, CA. plus. Job Description. The office manager position is responsible for overall office activities, including the reception area, mail, check distribution, ordering supplies, maintaining inventory, record keeping and assisting with facilities. Also responsible for directing and coordinating office services and relatedactivities.
LEADERSHIP - INCUBE LABSINCUBE LABS ADDRESSINCUBE LABS CA We have expertise across a range of disciplines: pharmacology and physiology, protein and polymer chemistry, tissue engineering, mechanical engineering and material science, electronics and software, industrial design, clinical development and manufacturing. Our leadership team also has deep experience in company building and commercializing innovations. INTRAPACE - INCUBE LABS IntraPace is developing an innovative product platform utilizing gastric stimulation for the treatment of obesity. IntraPace was founded in 2001 to address an unmet need in weight loss surgery by developing a gentler solution for weight loss that incorporates essential components of behavior therapy. The abiliti system is intended to enable patients to achieve and HOME - INCUBE LABSWHO WE AREWHAT WE DOPORTFOLIONEWSCAREERSCONTACT US Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia
OUR PORTFOLIO
Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia
WHO WE ARE - INCUBE LABS Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. OUR STORY - INCUBE LABSINCUBE LABS ADDRESSINCUBE LABS CA Our Innovation Timeline At any given time, we are working on several research projects across a range of disciplines and therapeutic areas. This work can span months to years. Our projects are heavily vetted and only those that meet our scientific and business criteria areformed into a
LOCATIONS - INCUBE LABSINCUBE FZCOINCUBE LABS LLCINCUBE MOBILITYINCUBEVENTURES
Our Locations Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials.NEWS AND ARTICLES
InCube in the News. Read more about InCube, Mir and our portfolio companies in the news. InCube portfolio company, Rani Therapeutics, is garnering attention for its novel approach to the oral delivery of biologics, considered the Holy Grail in Drug Delivery.featured-prev-blue.
ADVISORS - INCUBE LABSINCUBE LABS ADDRESSINCUBE LABS CA Peter Barton Hutt is a Partner specializing in food and drug law in the Washington, D.C. law firm of ovington & Burling. He served as Chief Counsel for the FDA from 1971-1975 and is the co-author of a casebook used to teach food and drug law throughout the country. Mr. Hutt currently serves on the Boards of Directors of several public andCAREERS WITH INCUBE
Milpitas, CA. plus. Job Description. The office manager position is responsible for overall office activities, including the reception area, mail, check distribution, ordering supplies, maintaining inventory, record keeping and assisting with facilities. Also responsible for directing and coordinating office services and relatedactivities.
LEADERSHIP - INCUBE LABSINCUBE LABS ADDRESSINCUBE LABS CA We have expertise across a range of disciplines: pharmacology and physiology, protein and polymer chemistry, tissue engineering, mechanical engineering and material science, electronics and software, industrial design, clinical development and manufacturing. Our leadership team also has deep experience in company building and commercializing innovations. INTRAPACE - INCUBE LABS IntraPace is developing an innovative product platform utilizing gastric stimulation for the treatment of obesity. IntraPace was founded in 2001 to address an unmet need in weight loss surgery by developing a gentler solution for weight loss that incorporates essential components of behavior therapy. The abiliti system is intended to enable patients to achieve andOUR NETWORK
Modulus is ISO 9001:2008 and ISO 13485:2003 certified for Class III medical devices. Modulus is co-located with InCube Labs at our Milpitas facility. Modulus assists InCube portfolio companies with prototyping through full scale production. Modulus also works with outside companies on their manufacturing needs. The company was established in 1972. LOCATIONS - INCUBE LABS Our Locations Our research approach is driven entirely by clinical need. In our 22 years of work, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. CONTACT US - INCUBE LABS Get in touch We are excited about our companies and their potential to improve the lives of millions of patients. If you are interested in learning more about us and our portfolio companies, please reach out. Whether you are a potential investor, collaboration partner, media contact or potential employee, we want to hear from you! SACRAMED - INCUBE LABS SacraMed is a medical technology company focused on the development of a neuromodulation system for the treatment of Overactive bladder (OAB). OAB is a bladder disorder that results in an abnormal urge to urinate, with or without urinary incontinence. It can occur at any age, but is most common in the elderly population. Approximately 1 ABOUT MIR - INCUBE LABS Mir Imran Mir’s passion for improving healthcare started at a young age. Early in his career, Mir spent a summer working at The Matheney School, which specialized in treating children with cerebral palsy. While there, Mir invented a device that translated facial expressions into speech, allowing those children to communicate. It was a profoundexample
FE3 MEDICAL
Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medical innovations. 25 million people in the US alone have mild to moderateanemia, making it
RANI - INCUBE LABS
The concept for Rani was developed by Mir Imran, a prolific medical inventor and entrepreneur who has founded more than twenty life sciences companies. Rani was established as a company in 2012 after several years as a research project within InCube Labs, Mir’s multi-disciplinary life sciences lab focused on developing and commercializing breakthrough innovations.PHIL MORGAN
Phil Morgan brings more than 25 years of pharmaceutical research and development experience to InCube Labs and has extensive experience in drug development and the regulatory approval process. He was the pre-clinical pharmacology expert for several drugs including Wellbutrin SR and Zyban. Prior to joining InCube Labs, Phil co-founded several successful life science companies andPETER BARTON HUTT
Peter Barton Hutt is a Partner specializing in food and drug law in the Washington, D.C. law firm of ovington & Burling. He served as Chief Counsel for the FDA from 1971-1975 and is the co-author of a casebook used to teach food and drug law throughout the country. Mr. Hutt currently serves on theANGELA MURCH
Angela brings more than fifteen years of experience in engineering and eight years of experience in the legal profession to InCube. Angela has experience in patent prosecution and litigation across various technologies, such as medical devices and systems, robots and robotic systems, optics, signal processing and circuitry, wireless power transfer devices and systems, and control* Who We Are
* Leadership
* Advisors
* About Mir
* What we do
* Portfolio
* News
* Careers
* Contact Us
CREATING NEW STANDARDS OF CARE IN MEDICINEAbout InCube Labs
FOCUS ON CONVERGENCE OF DRUGS AND DEVICESAbout InCube Labs
NOVEL THERAPIES FOR CHRONIC DISEASESAbout InCube Labs
* 1
* 2
* 3
24
Companies
Founded
15
Exits
900+
Patent
Applications (Filed)WELCOME TO OUR LAB
We are a multi-disciplinary life sciences lab focused on developingand commercializing
breakthrough innovations. We seek to understand the biggest challengesin healthcare
and develop innovative and effective treatment solutions that have thepotential to
improve the lives of millions of patients.RANI
------------------------- Oral Biologics Delivery vs. Making Oral Biologics a Reality MAKING ORAL BIOLOGICS A REALITY The concept for Rani was developed by Mir Imran, a prolific medical inventor and entrepreneur who has founded more than twenty lifesciences companies.
Rani was established as a company in 2012 after several years as a research project within InCube Labs, Mir’s multi-disciplinary life sciences lab focused on developing and commercializing breakthroughinnovations.
The Rani platform is capable of delivering a wide range of biologics for the treatment of various chronic diseases.View Company
SACRAMED
------------------------- Treatment of overactive bladder with sacral nerve stimulation SACRAL NERVE STIMULATION SacraMed is a medical technology company focused on the development of a neuromodulation system for the treatment of Overactive bladder (OAB). OAB is a bladder disorder that results in an abnormal urge to urinate, with or without urinary incontinence. It can occur at any age, but is most common in the elderly population. Approximately 1 in 6 adults suffers from OAB. It is a treatable condition, and at SacraMed we are working on advancing the tools and techniques to help bring relief to patients.FE3 MEDICAL
------------------------- Breakthrough Therapy for Iron Deficiency Anemia BREAKTHROUGH THERAPY - ANEMIA Fe3 is an early stage company developing a novel transdermal therapy for the treatment of iron deficiency anemia. The approach and technology for Fe3 was developed at InCube Labs, a multi-disciplinary life sciences R&D lab focused on developing breakthrough medicalinnovations.
25 million people in the US alone have mild to moderate anemia, making it one of the most prevalent micro-nutrient deficiencies.View Company
NEUROLINK
-------------------------Medical Therapy to
Treat Epilepsy
MEDICAL THERAPY TO THREAT EPILEPSY Neurolink is an early stage company developing a novel therapy for the treatment of epilepsy. Nearly three million Americans suffer from epilepsy, a neurological condition characterized by seizures. One of the most common neurological diseases, epilepsy affects approximately 1% of the population - 1 in 26 people will have epilepsy in their lifetime.View Company
THERACLE
------------------------- Implantable drug-device combination therapy for brain cancer DEVELOPING AN IMPLANTABLE DRUG-DEVICE Theracle is developing an implantable drug-device combination therapyfor gliomas.
The approach uses an implantable drug-delivery device, bypassing the blood-brain barrier. The device will provide an ability to focus treatment directly at the cancer site using one or more drugs, and it is expected that treatment will result in no peripheral adverse effects. It is planned to pursue an FDA orphan drug designation, with fast-track status towards regulatory approval.View Company
portfolio
OUR NETWORK
InCube has a broad and deep network of resources in a variety of disciplines including clinical, regulatory, reimbursement, manufacturing, and quality as well as investors and corporate, academic and government partners. We also have close collaborations with InCube Ventures, VentureHealth and Modulus which provide funding and manufacturing support to our portfolio companies.View Network
OUR PROCESS OF INNOVATION Our innovation process is centered on the identification and framing of a clinical problem that is worthy of a new solution. Throughout the years, we have addressed a number of clinical needs with implantable devices, drug delivery combinations, interventional devices and the use of novel biomaterials. Throughout our innovation process, we develop robust intellectual property. * 1 Identify the Problem * 2 Frame the Problem * 3 Develop and Test Solutions * 4 Develop Products & Manufacturing Processes1
Our objective is to create new therapies that will have a significant and positive impact on patients. This starts with identifying the most important problems in healthcare, those with few or inadequate currentsolutions.
2
Our work requires a background in all disciplines relevant to the problem we are trying to solve. As we frame the problem, we spend considerable time understanding the scientific basis of the problem, and the clinical implementation of a potential solution.3
Once we understand and research the problem and the market, we are ready to develop potential solutions. The solutions that are most commercially viable move from a research project to become one of our portfolio companies.4
As we develop products, we form companies and put together the resources needed for product development, clinical trials, regulatory approval and commercialization. Getting our innovations to patients is our most important goal. OUR MISSION IS TO IMPROVE THE QUALITY OF LIFE FOR PATIENTS AND REDUCE HEALTHCARE COSTS.THERAPEUTIC AREAS
* Urology
* Gastroenterology
* Women’s health
* CNS disorders
* Orthopedics
* Metabolic disease
* Oncology
UROLOGY
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UROLOGY
Overactive bladder affects millions of patients and is a growing problem with our aging population. In addition, neurogenic bladder can lead to a number of urinary conditions in people who lack bladder control due to brain, spinal cord or nerve problems. These conditions are debilitating and can dramatically affect a person’s quality of life. Our team is developing novel solutions for the treatment of urological conditions including implantable neuromodulation devices.UROLOGY
Overactive bladder affects millions of patients and is a growing problem with our aging population. In addition, neurogenic bladder can lead to a number of urinary conditions in people who lack bladder control due to brain, spinal cord or nerve problems. These conditions are debilitating and can dramatically affect a person’s quality of life. Our team is developing novel solutions for the treatment of urological conditions including implantable neuromodulation devices.GASTROENTEROLOGY
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GASTROENTEROLOGY
Inflammatory bowel disease (IBD) is a group of inflammatory conditions – including Crohn’s disease and ulcerative colitis – that affect the colon and small intestine. These diseases affect more than 1 in 500 Americans. Symptoms include abdominal pain, diarrhea, hematochezia, and weight loss, in addition to other associated problems such as iron deficiency anemia. We have several innovations in the area of gastroenterology from oral delivery of biologics to site specific drug delivery and intestinal sensors for detectinginflammation.
GASTROENTEROLOGY
Inflammatory bowel disease (IBD) is a group of inflammatory conditions – including Crohn’s disease and ulcerative colitis – that affect the colon and small intestine. These diseases affect more than 1 in 500 Americans. Symptoms include abdominal pain, diarrhea, hematochezia, and weight loss, in addition to other associated problems such as iron deficiency anemia. We have several innovations in the area of gastroenterology from oral delivery of biologics to site specific drug delivery and intestinal sensors for detectinginflammation.
WOMEN’S HEALTH
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WOMEN’S HEALTH
We are focused on a number of innovations for women’s health, including a novel solution for the treatment of iron deficiency anemia. 25 million people in the US alone have mild to moderate anemia, making it one of the most prevalent micro-nutrient deficiencies. These people, mainly women, suffer from a variety of undesirable consequences including fatigue, poor cognition and motorfunction.
WOMEN’S HEALTH
We are focused on a number of innovations for women’s health, including a novel solution for the treatment of iron deficiency anemia. 25 million people in the US alone have mild to moderate anemia, making it one of the most prevalent micro-nutrient deficiencies. These people, mainly women, suffer from a variety of undesirable consequences including fatigue, poor cognition and motorfunction.
CNS DISORDERS
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CNS DISORDERS
Central nervous system (CNS) disorders is the leading therapeutic category of the US pharma market. Examples include migraine, depression, Huntington’s disease, Alzheimer’s and Parkinson’s. Given the magnitude of the problem and the vast number of patients affected by CNS disorders, we are looking for new ways to improve treatments across various CNS diseases, including a novel implantable device to treat epilepsy. We’re applying technology and innovative methods to transform how patients are treated, with the goal of better care and quality of life for CNS patients.CNS DISORDERS
Central nervous system (CNS) disorders is the leading therapeutic category of the US pharma market. Examples include migraine, depression, Huntington’s disease, Alzheimer’s and Parkinson’s. Given the magnitude of the problem and the vast number of patients affected by CNS disorders, we are looking for new ways to improve treatments across various CNS diseases, including a novel implantable device to treat epilepsy. We’re applying technology and innovative methods to transform how patients are treated, with the goal of better care and quality of life for CNS patients.ORTHOPEDICS
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ORTHOPEDICS
Our team has conducted research into the musculoskeletal system, and the conditions affecting bones, joints, muscles, tendons, ligaments, cartilage and nerves. We are focused on developing novel new approaching for bone healing including the creation of biomaterials.ORTHOPEDICS
Our team has conducted research into the musculoskeletal system, and the conditions affecting bones, joints, muscles, tendons, ligaments, cartilage and nerves. We are focused on developing novel new approaching for bone healing including the creation of biomaterials.METABOLIC DISEASE
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METABOLIC DISEASE
Metabolic diseases result from a disruption in the body’s homeostatic mechanisms regulating the energy balance – the process of getting or using energy from food intake. More than 100 million people in the US alone suffer two of the most prevalent diseases, diabetes and obesity. Treatments vary depending on the type of metabolic disease. We are currently focused on developing new approaches for addressing both diabetes and obesity.METABOLIC DISEASE
Metabolic diseases result from a disruption in the body’s homeostatic mechanisms regulating the energy balance – the process of getting or using energy from food intake. More than 100 million people in the US alone suffer two of the most prevalent diseases, diabetes and obesity. Treatments vary depending on the type of metabolic disease. We are currently focused on developing new approaches for addressing both diabetes and obesity.ONCOLOGY
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ONCOLOGY
Cancer is the second leading cause of death in the US behind only heart disease. The disease is enormously taxing on our healthcare system, and while there are a variety of treatment options available, few are curative. Our work is focused on identifying new breakthrough approaches for treating the disease. Because each cancer is unique and there are variants even within the same subtype, we are exploring implantable devices and personalized medicine to dramatically improve the quality of care for cancer patients.ONCOLOGY
Cancer is the second leading cause of death in the US behind only heart disease. The disease is enormously taxing on our healthcare system, and while there are a variety of treatment options available, few are curative. Our work is focused on identifying new breakthrough approaches for treating the disease. Because each cancer is unique and there are variants even within the same subtype, we are exploring implantable devices and personalized medicine to dramatically improve the quality of care for cancer patients.OUR CHIEF INNOVATOR
Mir Imran is recognized as one of the leading inventors and entrepreneurs in the healthcare field. Mir has created two dozen companies, many of which have successfully exited through acquisition or IPO. He now holds more than 600 issued or pending US patents and many of his innovations have become standards of care.MORE ON MIR
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