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PLR LTD. | CONTACT US / SALES Contact Us / Sales. 11 Hagefen Str. Rehovot, 76349 Israel. Phone / Fax: +972-89. _. 489006. To establish a connection with PLR, and if you are interested in any additional information such as pricing and availability of PLR products or any services provided by PLR, please fill the following details and press the Send button below.PLR LTD. | ARTICLES
A Pegylated Leptin Antagonist Ameliorates CKD-Associated Cachexia in Mice. Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity. Leptin-activity blockers: development and potential use in experimental biology and medicine. Effect of peripherally administered leptin antagonist on whole bodymetabolism and
PLR LTD. | TECHNICAL INFORMATION PLR specializes in making recombinant proteins in E. coli and has knowledge and experience executing all the steps of the process starting with palnning of the expressed gene and ending with the purified biologically active protein.. We start from planning the optimized sequence, over-expressing it as insoluble protein, purifying the inclusion bodies and finally refolding it as a biologically PLR LTD. | GROWTH HORMONES, PROLACTINS, PLACENTAL LACTOGENS Bovine placental lactogen - Cat no. GHP-20 GENE ID 281097. Caprine placental lactogen - Cat no. GHP-19 GENE ID 100861230. Chicken growth hormone (chGH) Cat no GHP-1 GENE ID 378781. Chicken growth hormone (chGH) antagonist (G119R) Cat no GHP-2 GENE ID 378781. Chicken prolactin (chPRL) - Cat. no. GHP-37 GENe ID 196660 NEW. PLR LTD. | PROF. ARIEH GERTLER In October 2003 Prof. Gertler retired from the Hebrew University, founded PLR Ltd, but in addition to the activity as a Director and CEO he continues basic research in his University laboratory in collaboration with many groups in North America, Europe and New Zealand. Present projects carried out in this laboratory include: (1)Development and
PLR LTD. | DR. GILI SOLOMON- CHIEF SCIENTIST Dr. Solomon received her PhD in Biochemistry & Food Science, in the Hebrew University of Jerusalem, Faculty of Agriculture, Food and Environmental Quality Sciences, Rehovot, Israel. Her M.Sc. in Food Science, Rutgers University, New Brunswick, NJ, USA and her B.Sc. in Life Sciences - Biology, Tel-Aviv University, Tel-Aviv, Israel. BRAIN, BEHAVIOR, AND IMMUNITY is indicative of behavioral despair in rodents (Collin et al., 2000; Yamada et al., 2011). Additionally, db/db mice, which lack func-tional leptin receptors, exhibit increased immobility time in the CENTRAL RESISTIN/TLR4 IMPAIRS ADIPONECTIN SIGNALING Yacir Benomar,1,2 Hamza Amine,1,2 Délphine Crépin,1,2 Sarah Al Rifai,1,2 Laure Riffault,1,2 Arieh Gertler,3 and Mohammed Taouis1,2 Central Resistin/TLR4 Impairs Adiponectin Signaling, Contributing to Insulin and FGF21 Resistance Diabetes 2016;65:913–926 | DOI:10.2337/db15-1029
PLR LTD. | PROTEIN LABORATORIES REHOVOT LTD. About Protein Laboratories Rehovot Protein Laboratories Rehovot (PLR) Ltd. was founded in August 2003. The company is jointly owned by Professor Arieh Gertler – holder of Karl Bach Chair in Agricultural Biochemistry of the Hebrew University, Israel who retired in October 2003, and Mr. Gopal Savjani from Houston, Texas, USA. PLR LTD. | PRODUCTS INDEX OF RECOMBINANT PROTEINS Products Index of Recombinant proteins. We are the ONLY company producing leptin antagonists and leptins of farm animals including several fish species. Pegylated human, mouse, rat and ovine leptins and corresponding leptin antagonists are now available!!! PLR provides a novel service of pegylation of either existing, or provided orcustom-made
PLR LTD. | CONTACT US / SALES Contact Us / Sales. 11 Hagefen Str. Rehovot, 76349 Israel. Phone / Fax: +972-89. _. 489006. To establish a connection with PLR, and if you are interested in any additional information such as pricing and availability of PLR products or any services provided by PLR, please fill the following details and press the Send button below.PLR LTD. | ARTICLES
A Pegylated Leptin Antagonist Ameliorates CKD-Associated Cachexia in Mice. Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity. Leptin-activity blockers: development and potential use in experimental biology and medicine. Effect of peripherally administered leptin antagonist on whole bodymetabolism and
PLR LTD. | TECHNICAL INFORMATION PLR specializes in making recombinant proteins in E. coli and has knowledge and experience executing all the steps of the process starting with palnning of the expressed gene and ending with the purified biologically active protein.. We start from planning the optimized sequence, over-expressing it as insoluble protein, purifying the inclusion bodies and finally refolding it as a biologically PLR LTD. | GROWTH HORMONES, PROLACTINS, PLACENTAL LACTOGENS Bovine placental lactogen - Cat no. GHP-20 GENE ID 281097. Caprine placental lactogen - Cat no. GHP-19 GENE ID 100861230. Chicken growth hormone (chGH) Cat no GHP-1 GENE ID 378781. Chicken growth hormone (chGH) antagonist (G119R) Cat no GHP-2 GENE ID 378781. Chicken prolactin (chPRL) - Cat. no. GHP-37 GENe ID 196660 NEW. PLR LTD. | PROF. ARIEH GERTLER In October 2003 Prof. Gertler retired from the Hebrew University, founded PLR Ltd, but in addition to the activity as a Director and CEO he continues basic research in his University laboratory in collaboration with many groups in North America, Europe and New Zealand. Present projects carried out in this laboratory include: (1)Development and
PLR LTD. | DR. GILI SOLOMON- CHIEF SCIENTIST Dr. Solomon received her PhD in Biochemistry & Food Science, in the Hebrew University of Jerusalem, Faculty of Agriculture, Food and Environmental Quality Sciences, Rehovot, Israel. Her M.Sc. in Food Science, Rutgers University, New Brunswick, NJ, USA and her B.Sc. in Life Sciences - Biology, Tel-Aviv University, Tel-Aviv, Israel. BRAIN, BEHAVIOR, AND IMMUNITY is indicative of behavioral despair in rodents (Collin et al., 2000; Yamada et al., 2011). Additionally, db/db mice, which lack func-tional leptin receptors, exhibit increased immobility time in the CENTRAL RESISTIN/TLR4 IMPAIRS ADIPONECTIN SIGNALING Yacir Benomar,1,2 Hamza Amine,1,2 Délphine Crépin,1,2 Sarah Al Rifai,1,2 Laure Riffault,1,2 Arieh Gertler,3 and Mohammed Taouis1,2 Central Resistin/TLR4 Impairs Adiponectin Signaling, Contributing to Insulin and FGF21 Resistance Diabetes 2016;65:913–926 | DOI:10.2337/db15-1029
PLR LTD. | TECHNICAL INFORMATION PLR specializes in making recombinant proteins in E. coli and has knowledge and experience executing all the steps of the process starting with palnning of the expressed gene and ending with the purified biologically active protein.. We start from planning the optimized sequence, over-expressing it as insoluble protein, purifying the inclusion bodies and finally refolding it as a biologically PLR LTD. | SOLUBLE RECEPTORS Bovine prolactin soluble receptor ECD - Cat. no. ECD-11 GENE ID 281422. Chicken leptin binding domain (chLBD) - Cat no. LBD-1 GENE ID 374223. Human growth hormone soluble receptor (so called hGH binding protein) - Cat no. ECD-1 GENE ID 2690 PLR LTD. | DR. GILI SOLOMON- CHIEF SCIENTIST Dr. Solomon received her PhD in Biochemistry & Food Science, in the Hebrew University of Jerusalem, Faculty of Agriculture, Food and Environmental Quality Sciences, Rehovot, Israel. Her M.Sc. in Food Science, Rutgers University, New Brunswick, NJ, USA and her B.Sc. in Life Sciences - Biology, Tel-Aviv University, Tel-Aviv, Israel. PLR LTD. | HUMAN PITUITARY GROWTH HORMONE 20 K Recombinant pituitary human growth hormone - 20K produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 177 amino acids and having a molecular mass of 20322 Dalton. PLR LTD. | RABBIT GROWTH HORMONE Recombinant rabbit growth hormone (rbGH), one polypeptide chain containing 190 amino and an additional Ala at N-terminus acids and having a molecular mass of ~ 21.5 kDa, was purified by proprietary chromatographic techniques (unpublished data). PHYSIOLOGY & BEHAVIOR Principles of strategic drug delivery to the brain (SDDB): Development of anorectic and orexigenic analogs of leptin W.A. Banks a,⁎, A. Gertler b, G. Solomon b, L. Niv-Spector b, M. Shpilman b,X.Yic, E. Batrakova c, S. Vinogradov c, A.V. Kabanov c,d a Geriatrics Research Education and Clinical Center – Veterans Affairs Puget Sound Health Care System and Division of Gerontology and NOVEL REAGENTS FOR HUMAN PROLACTIN RESEARCH: LARGE-SCALE Protein Engineering, Design & Selection, 2017, pp. 1–10 doi: 10.1093/protein/gzx062 Original Article Original Article Novel reagents for human prolactin research:PLR-LTD.COM
plr-ltd.com
LARGE-SCALE PREPARATION OF BIOLOGICALLY ACTIVE MOUSE AND 130 G. Salomon et al. / Protein Expression and PuriWcation 47 (2006) 128–136 Preparation of mouse and rat leptin muteins L39A/D40A/ F41A To prepare the leptin mutants, the pMon3401 expression plasmids encoding the wild-type (WT) rat or mouse leptinINVITED REVIEW
INVITED REVIEW Leptin-activity blockers: development and potential use in experimental biology and medicine1 Arieh Gertler and Gili SolomonAbstract
PLR LTD. | PROTEIN LABORATORIES REHOVOT LTD. About Protein Laboratories Rehovot Protein Laboratories Rehovot (PLR) Ltd. was founded in August 2003. The company is jointly owned by Professor Arieh Gertler – holder of Karl Bach Chair in Agricultural Biochemistry of the Hebrew University, Israel who retired in October 2003, and Mr. Gopal Savjani from Houston, Texas, USA. PLR LTD. | PRODUCTS INDEX OF RECOMBINANT PROTEINS Products Index of Recombinant proteins. We are the ONLY company producing leptin antagonists and leptins of farm animals including several fish species. Pegylated human, mouse, rat and ovine leptins and corresponding leptin antagonists are now available!!! PLR provides a novel service of pegylation of either existing, or provided orcustom-made
PLR LTD. | CONTACT US / SALES Contact Us / Sales. 11 Hagefen Str. Rehovot, 76349 Israel. Phone / Fax: +972-89. _. 489006. To establish a connection with PLR, and if you are interested in any additional information such as pricing and availability of PLR products or any services provided by PLR, please fill the following details and press the Send button below. PLR LTD. | TECHNICAL INFORMATION PLR specializes in making recombinant proteins in E. coli and has knowledge and experience executing all the steps of the process starting with palnning of the expressed gene and ending with the purified biologically active protein.. We start from planning the optimized sequence, over-expressing it as insoluble protein, purifying the inclusion bodies and finally refolding it as a biologicallyPLR LTD. | ARTICLES
A Pegylated Leptin Antagonist Ameliorates CKD-Associated Cachexia in Mice. Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity. Leptin-activity blockers: development and potential use in experimental biology and medicine. Effect of peripherally administered leptin antagonist on whole bodymetabolism and
PLR LTD. | GROWTH HORMONES, PROLACTINS, PLACENTAL LACTOGENS Bovine placental lactogen - Cat no. GHP-20 GENE ID 281097. Caprine placental lactogen - Cat no. GHP-19 GENE ID 100861230. Chicken growth hormone (chGH) Cat no GHP-1 GENE ID 378781. Chicken growth hormone (chGH) antagonist (G119R) Cat no GHP-2 GENE ID 378781. Chicken prolactin (chPRL) - Cat. no. GHP-37 GENe ID 196660 NEW. PLR LTD. | PROF. ARIEH GERTLER In October 2003 Prof. Gertler retired from the Hebrew University, founded PLR Ltd, but in addition to the activity as a Director and CEO he continues basic research in his University laboratory in collaboration with many groups in North America, Europe and New Zealand. Present projects carried out in this laboratory include: (1)Development and
PLR LTD. | OVINE PROLACTIN SOLUBLE RECEPTOR (OPRLR-ECD Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development andreproduction.
PLR LTD. | MOUSE PEGYLATED INTERLEUKIN 22 Y51A ANTAGONIST Lyophilized pegylated mouse IL22 although stable at room temperature for several days, should be stored desiccated below -20C. Upon reconstitution at > 0.1 pegylated mIL22 mg/ml and up to 2 mg/ml and filter sterilization it can be stored at 4C or even room temperature for several weeks making it suitable for long term infusion studies using osmotic pumps. PLR LTD. | DR. GILI SOLOMON- CHIEF SCIENTIST Dr. Solomon received her PhD in Biochemistry & Food Science, in the Hebrew University of Jerusalem, Faculty of Agriculture, Food and Environmental Quality Sciences, Rehovot, Israel. Her M.Sc. in Food Science, Rutgers University, New Brunswick, NJ, USA and her B.Sc. in Life Sciences - Biology, Tel-Aviv University, Tel-Aviv, Israel. PLR LTD. | PROTEIN LABORATORIES REHOVOT LTD. About Protein Laboratories Rehovot Protein Laboratories Rehovot (PLR) Ltd. was founded in August 2003. The company is jointly owned by Professor Arieh Gertler – holder of Karl Bach Chair in Agricultural Biochemistry of the Hebrew University, Israel who retired in October 2003, and Mr. Gopal Savjani from Houston, Texas, USA. PLR LTD. | PRODUCTS INDEX OF RECOMBINANT PROTEINS Products Index of Recombinant proteins. We are the ONLY company producing leptin antagonists and leptins of farm animals including several fish species. Pegylated human, mouse, rat and ovine leptins and corresponding leptin antagonists are now available!!! PLR provides a novel service of pegylation of either existing, or provided orcustom-made
PLR LTD. | CONTACT US / SALES Contact Us / Sales. 11 Hagefen Str. Rehovot, 76349 Israel. Phone / Fax: +972-89. _. 489006. To establish a connection with PLR, and if you are interested in any additional information such as pricing and availability of PLR products or any services provided by PLR, please fill the following details and press the Send button below. PLR LTD. | TECHNICAL INFORMATION PLR specializes in making recombinant proteins in E. coli and has knowledge and experience executing all the steps of the process starting with palnning of the expressed gene and ending with the purified biologically active protein.. We start from planning the optimized sequence, over-expressing it as insoluble protein, purifying the inclusion bodies and finally refolding it as a biologicallyPLR LTD. | ARTICLES
A Pegylated Leptin Antagonist Ameliorates CKD-Associated Cachexia in Mice. Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity. Leptin-activity blockers: development and potential use in experimental biology and medicine. Effect of peripherally administered leptin antagonist on whole bodymetabolism and
PLR LTD. | GROWTH HORMONES, PROLACTINS, PLACENTAL LACTOGENS Bovine placental lactogen - Cat no. GHP-20 GENE ID 281097. Caprine placental lactogen - Cat no. GHP-19 GENE ID 100861230. Chicken growth hormone (chGH) Cat no GHP-1 GENE ID 378781. Chicken growth hormone (chGH) antagonist (G119R) Cat no GHP-2 GENE ID 378781. Chicken prolactin (chPRL) - Cat. no. GHP-37 GENe ID 196660 NEW. PLR LTD. | PROF. ARIEH GERTLER In October 2003 Prof. Gertler retired from the Hebrew University, founded PLR Ltd, but in addition to the activity as a Director and CEO he continues basic research in his University laboratory in collaboration with many groups in North America, Europe and New Zealand. Present projects carried out in this laboratory include: (1)Development and
PLR LTD. | OVINE PROLACTIN SOLUBLE RECEPTOR (OPRLR-ECD Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development andreproduction.
PLR LTD. | MOUSE PEGYLATED INTERLEUKIN 22 Y51A ANTAGONIST Lyophilized pegylated mouse IL22 although stable at room temperature for several days, should be stored desiccated below -20C. Upon reconstitution at > 0.1 pegylated mIL22 mg/ml and up to 2 mg/ml and filter sterilization it can be stored at 4C or even room temperature for several weeks making it suitable for long term infusion studies using osmotic pumps. PLR LTD. | DR. GILI SOLOMON- CHIEF SCIENTIST Dr. Solomon received her PhD in Biochemistry & Food Science, in the Hebrew University of Jerusalem, Faculty of Agriculture, Food and Environmental Quality Sciences, Rehovot, Israel. Her M.Sc. in Food Science, Rutgers University, New Brunswick, NJ, USA and her B.Sc. in Life Sciences - Biology, Tel-Aviv University, Tel-Aviv, Israel. PLR LTD. | SOLUBLE RECEPTORS Bovine prolactin soluble receptor ECD - Cat. no. ECD-11 GENE ID 281422. Chicken leptin binding domain (chLBD) - Cat no. LBD-1 GENE ID 374223. Human growth hormone soluble receptor (so called hGH binding protein) - Cat no. ECD-1 GENE ID 2690 PLR LTD. | DR. GILI SOLOMON- CHIEF SCIENTIST Dr. Solomon received her PhD in Biochemistry & Food Science, in the Hebrew University of Jerusalem, Faculty of Agriculture, Food and Environmental Quality Sciences, Rehovot, Israel. Her M.Sc. in Food Science, Rutgers University, New Brunswick, NJ, USA and her B.Sc. in Life Sciences - Biology, Tel-Aviv University, Tel-Aviv, Israel. PLR LTD. | HUMAN PITUITARY GROWTH HORMONE 20 K Recombinant pituitary human growth hormone - 20K produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 177 amino acids and having a molecular mass of 20322 Dalton. PLR LTD. | RABBIT GROWTH HORMONE Recombinant rabbit growth hormone (rbGH), one polypeptide chain containing 190 amino and an additional Ala at N-terminus acids and having a molecular mass of ~ 21.5 kDa, was purified by proprietary chromatographic techniques (unpublished data). PHYSIOLOGY & BEHAVIOR Principles of strategic drug delivery to the brain (SDDB): Development of anorectic and orexigenic analogs of leptin W.A. Banks a,⁎, A. Gertler b, G. Solomon b, L. Niv-Spector b, M. Shpilman b,X.Yic, E. Batrakova c, S. Vinogradov c, A.V. Kabanov c,d a Geriatrics Research Education and Clinical Center – Veterans Affairs Puget Sound Health Care System and Division of Gerontology and NOVEL REAGENTS FOR HUMAN PROLACTIN RESEARCH: LARGE-SCALE Protein Engineering, Design & Selection, 2017, pp. 1–10 doi: 10.1093/protein/gzx062 Original Article Original Article Novel reagents for human prolactin research: LARGE-SCALE PREPARATION OF BIOLOGICALLY ACTIVE MOUSE AND 130 G. Salomon et al. / Protein Expression and PuriWcation 47 (2006) 128–136 Preparation of mouse and rat leptin muteins L39A/D40A/ F41A To prepare the leptin mutants, the pMon3401 expression plasmids encoding the wild-type (WT) rat or mouse leptinPLR-LTD.COM
plr-ltd.com
INVITED REVIEW
INVITED REVIEW Leptin-activity blockers: development and potential use in experimental biology and medicine1 Arieh Gertler and Gili SolomonAbstract
PLR LTD. | PROTEIN LABORATORIES REHOVOT LTD. PLR Ltd. | Protein Laboratories Rehovot Ltd. PLR LTD. | PROTEIN LABORATORIES REHOVOT LTD. About Protein Laboratories Rehovot Protein Laboratories Rehovot (PLR) Ltd. was founded in August 2003. The company is jointly owned by Professor Arieh Gertler – holder of Karl Bach Chair in Agricultural Biochemistry of the Hebrew University, Israel who retired in October 2003, and Mr. Gopal Savjani from Houston, Texas, USA. PLR LTD. | PRODUCTS INDEX OF RECOMBINANT PROTEINS Products Index of Recombinant proteins. We are the ONLY company producing leptin antagonists and leptins of farm animals including several fish species. Pegylated human, mouse, rat and ovine leptins and corresponding leptin antagonists are now available!!! PLR provides a novel service of pegylation of either existing, or provided orcustom-made
PLR LTD. | CONTACT US / SALES Contact Us / Sales. 11 Hagefen Str. Rehovot, 76349 Israel. Phone / Fax: +972-89. _. 489006. To establish a connection with PLR, and if you are interested in any additional information such as pricing and availability of PLR products or any services provided by PLR, please fill the following details and press the Send button below. PLR LTD. | TECHNICAL INFORMATION PLR specializes in making recombinant proteins in E. coli and has knowledge and experience executing all the steps of the process starting with palnning of the expressed gene and ending with the purified biologically active protein.. We start from planning the optimized sequence, over-expressing it as insoluble protein, purifying the inclusion bodies and finally refolding it as a biologicallyPLR LTD. | ARTICLES
A Pegylated Leptin Antagonist Ameliorates CKD-Associated Cachexia in Mice. Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity. Leptin-activity blockers: development and potential use in experimental biology and medicine. Effect of peripherally administered leptin antagonist on whole bodymetabolism and
PLR LTD. | GROWTH HORMONES, PROLACTINS, PLACENTAL LACTOGENS Bovine placental lactogen - Cat no. GHP-20 GENE ID 281097. Caprine placental lactogen - Cat no. GHP-19 GENE ID 100861230. Chicken growth hormone (chGH) Cat no GHP-1 GENE ID 378781. Chicken growth hormone (chGH) antagonist (G119R) Cat no GHP-2 GENE ID 378781. Chicken prolactin (chPRL) - Cat. no. GHP-37 GENe ID 196660 NEW. PLR LTD. | PROF. ARIEH GERTLER In October 2003 Prof. Gertler retired from the Hebrew University, founded PLR Ltd, but in addition to the activity as a Director and CEO he continues basic research in his University laboratory in collaboration with many groups in North America, Europe and New Zealand. Present projects carried out in this laboratory include: (1)Development and
PLR LTD. | OVINE PROLACTIN SOLUBLE RECEPTOR (OPRLR-ECD Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development andreproduction.
PLR LTD. | MOUSE PEGYLATED INTERLEUKIN 22 Y51A ANTAGONIST Lyophilized pegylated mouse IL22 although stable at room temperature for several days, should be stored desiccated below -20C. Upon reconstitution at > 0.1 pegylated mIL22 mg/ml and up to 2 mg/ml and filter sterilization it can be stored at 4C or even room temperature for several weeks making it suitable for long term infusion studies using osmotic pumps. PLR LTD. | DR. GILI SOLOMON- CHIEF SCIENTIST Dr. Solomon received her PhD in Biochemistry & Food Science, in the Hebrew University of Jerusalem, Faculty of Agriculture, Food and Environmental Quality Sciences, Rehovot, Israel. Her M.Sc. in Food Science, Rutgers University, New Brunswick, NJ, USA and her B.Sc. in Life Sciences - Biology, Tel-Aviv University, Tel-Aviv, Israel. PLR LTD. | PROTEIN LABORATORIES REHOVOT LTD. About Protein Laboratories Rehovot Protein Laboratories Rehovot (PLR) Ltd. was founded in August 2003. The company is jointly owned by Professor Arieh Gertler – holder of Karl Bach Chair in Agricultural Biochemistry of the Hebrew University, Israel who retired in October 2003, and Mr. Gopal Savjani from Houston, Texas, USA. PLR LTD. | PRODUCTS INDEX OF RECOMBINANT PROTEINS Products Index of Recombinant proteins. We are the ONLY company producing leptin antagonists and leptins of farm animals including several fish species. Pegylated human, mouse, rat and ovine leptins and corresponding leptin antagonists are now available!!! PLR provides a novel service of pegylation of either existing, or provided orcustom-made
PLR LTD. | CONTACT US / SALES Contact Us / Sales. 11 Hagefen Str. Rehovot, 76349 Israel. Phone / Fax: +972-89. _. 489006. To establish a connection with PLR, and if you are interested in any additional information such as pricing and availability of PLR products or any services provided by PLR, please fill the following details and press the Send button below. PLR LTD. | TECHNICAL INFORMATION PLR specializes in making recombinant proteins in E. coli and has knowledge and experience executing all the steps of the process starting with palnning of the expressed gene and ending with the purified biologically active protein.. We start from planning the optimized sequence, over-expressing it as insoluble protein, purifying the inclusion bodies and finally refolding it as a biologicallyPLR LTD. | ARTICLES
A Pegylated Leptin Antagonist Ameliorates CKD-Associated Cachexia in Mice. Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity. Leptin-activity blockers: development and potential use in experimental biology and medicine. Effect of peripherally administered leptin antagonist on whole bodymetabolism and
PLR LTD. | GROWTH HORMONES, PROLACTINS, PLACENTAL LACTOGENS Bovine placental lactogen - Cat no. GHP-20 GENE ID 281097. Caprine placental lactogen - Cat no. GHP-19 GENE ID 100861230. Chicken growth hormone (chGH) Cat no GHP-1 GENE ID 378781. Chicken growth hormone (chGH) antagonist (G119R) Cat no GHP-2 GENE ID 378781. Chicken prolactin (chPRL) - Cat. no. GHP-37 GENe ID 196660 NEW. PLR LTD. | PROF. ARIEH GERTLER In October 2003 Prof. Gertler retired from the Hebrew University, founded PLR Ltd, but in addition to the activity as a Director and CEO he continues basic research in his University laboratory in collaboration with many groups in North America, Europe and New Zealand. Present projects carried out in this laboratory include: (1)Development and
PLR LTD. | OVINE PROLACTIN SOLUBLE RECEPTOR (OPRLR-ECD Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development andreproduction.
PLR LTD. | MOUSE PEGYLATED INTERLEUKIN 22 Y51A ANTAGONIST Lyophilized pegylated mouse IL22 although stable at room temperature for several days, should be stored desiccated below -20C. Upon reconstitution at > 0.1 pegylated mIL22 mg/ml and up to 2 mg/ml and filter sterilization it can be stored at 4C or even room temperature for several weeks making it suitable for long term infusion studies using osmotic pumps. PLR LTD. | DR. GILI SOLOMON- CHIEF SCIENTIST Dr. Solomon received her PhD in Biochemistry & Food Science, in the Hebrew University of Jerusalem, Faculty of Agriculture, Food and Environmental Quality Sciences, Rehovot, Israel. Her M.Sc. in Food Science, Rutgers University, New Brunswick, NJ, USA and her B.Sc. in Life Sciences - Biology, Tel-Aviv University, Tel-Aviv, Israel. PLR LTD. | SOLUBLE RECEPTORS Bovine prolactin soluble receptor ECD - Cat. no. ECD-11 GENE ID 281422. Chicken leptin binding domain (chLBD) - Cat no. LBD-1 GENE ID 374223. Human growth hormone soluble receptor (so called hGH binding protein) - Cat no. ECD-1 GENE ID 2690 PLR LTD. | DR. GILI SOLOMON- CHIEF SCIENTIST Dr. Solomon received her PhD in Biochemistry & Food Science, in the Hebrew University of Jerusalem, Faculty of Agriculture, Food and Environmental Quality Sciences, Rehovot, Israel. Her M.Sc. in Food Science, Rutgers University, New Brunswick, NJ, USA and her B.Sc. in Life Sciences - Biology, Tel-Aviv University, Tel-Aviv, Israel. PLR LTD. | HUMAN PITUITARY GROWTH HORMONE 20 K Recombinant pituitary human growth hormone - 20K produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 177 amino acids and having a molecular mass of 20322 Dalton. PLR LTD. | RABBIT GROWTH HORMONE Recombinant rabbit growth hormone (rbGH), one polypeptide chain containing 190 amino and an additional Ala at N-terminus acids and having a molecular mass of ~ 21.5 kDa, was purified by proprietary chromatographic techniques (unpublished data). PHYSIOLOGY & BEHAVIOR Principles of strategic drug delivery to the brain (SDDB): Development of anorectic and orexigenic analogs of leptin W.A. Banks a,⁎, A. Gertler b, G. Solomon b, L. Niv-Spector b, M. Shpilman b,X.Yic, E. Batrakova c, S. Vinogradov c, A.V. Kabanov c,d a Geriatrics Research Education and Clinical Center – Veterans Affairs Puget Sound Health Care System and Division of Gerontology and NOVEL REAGENTS FOR HUMAN PROLACTIN RESEARCH: LARGE-SCALE Protein Engineering, Design & Selection, 2017, pp. 1–10 doi: 10.1093/protein/gzx062 Original Article Original Article Novel reagents for human prolactin research: LARGE-SCALE PREPARATION OF BIOLOGICALLY ACTIVE MOUSE AND 130 G. Salomon et al. / Protein Expression and PuriWcation 47 (2006) 128–136 Preparation of mouse and rat leptin muteins L39A/D40A/ F41A To prepare the leptin mutants, the pMon3401 expression plasmids encoding the wild-type (WT) rat or mouse leptinPLR-LTD.COM
plr-ltd.com
INVITED REVIEW
INVITED REVIEW Leptin-activity blockers: development and potential use in experimental biology and medicine1 Arieh Gertler and Gili SolomonAbstract
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Protein Laboratories Rehovot Ltd. __ __ Who We Are __ Technical info __ Products Index __ Articles ABOUT PROTEIN LABORATORIES REHOVOT Protein Laboratories Rehovot (PLR) Ltd. was founded in August 2003. The company is jointly owned by Professor Arieh Gertler – holder of Karl Bach Chair in Agricultural Biochemistry of the Hebrew University, Israel who retired in October 2003, and Mr. Gopal Savjani from Houston, Texas, USA. The Company produces biologically active recombinant proteins (mainly different cytokines and their soluble receptors), in E. coli, a know-how developed by Prof. Gertler during the last 20 years and unconditionally licensed to The Company by The Hebrew University and Yissum Co. PLR also has the know how to produce expression plasmids and recombinant proteins upon request. Those proteins can be produced in large (up to grams) quantities and be sold at very competitive prices. RECENTLY PLR HAS DEVELOPED A PEGYLATION SERVICE FOR EITHER EXISTING, PROVIDED OR CUSTOM MADE PROTEINS. FURTHERMORE PLR IS THE ONLY COMPANY SELLING LEPTIN ANTAGONISTS (MONO-PEGYLATED AND NON-PEGYLATED) AND MONO-PEGYLATED LEPTINS. PLR was founded without any major investments and its capital is based on the existing and novel expression plasmids, and the know-how ofProf. Gertler.
So far the Company has received orders for various recombinant proteins from commercial companies and research institutions. In addition to direct orders received mainly due to contacts of Prof. Gertler with companies and research institutions, PLR sells its products by agreements with other companies in Israel or abroad or directly to customers.Created by
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