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HOMEPAGE FEATURE
APS members work at the frontiers of science to advance our understanding of life and health. Their efforts are leading to treatments for the deadliest and most debilitating diseases affecting humans and enhancing our understanding of topics like genetics, neuroscience, obesity and sex differences. You can be part of thisvibrant community.
THE PHYSIOLOGY OF COVID-19 Sidebar: APS Journals Highlight COVID-19 Research . The American Physiological Society (APS) journals can serve as a reliable resource to the physiology community during the pandemic by sharing new findings on how coronaviruses affect the body and particular organsystems.
PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
PHYSIOLOGICAL REVIEWS: VOL 101, NO 2 Physiological Reviews Apr 2021 417-738. Cover: Fibroblast growth factors (FGFs) and tyrosine kinase FGF receptors play a key role in the physiopathology of the prostate gland via mutual interactions between mesenchymal and epithelial compartments. FGF signaling is required for prostate development and homeostasis, and its abnormal activation may lead to prostate hyperplasia and FLUID TRANSPORT IN THE BRAIN The blood-brain barrier establishes a stable environment that is optimal for neuronal function, yet the barrier imposes a physiological problem; transcapillary filtration that forms extracellular fluid in other organs is reduced to a minimum in brain. Consequently, the brain depends on a special fluid (the cerebrospinal fluid; CSF) that is EXPERIMENTAL BIOLOGY APS’s annual meeting is held every spring in conjunction with the Experimental Biology (EB) meeting. Five societies (APS, AAA, ASBMB, ASIP and ASPET) jointly sponsor EB. The result is an interdisciplinary, biomedical and scientific meeting featuring a robust lineup plenary and award lectures, symposia, oral and postersessions and career
SEVENTEENTH INTERNATIONAL CONFERENCE ON ENDOTHELIN (ET-17 The American Physiological Society’s (APS) Seventeenth International Conference on Endothelin (ET-17) will be held virtually October 4–7, 2021. Check back often as registration, abstract submission and awards information will be available soon. Sign up for conference announcements to stay in the know. This biennial event is the premier GUT MICROBIOTA IN HEALTH AND DISEASE Gut Microbiota in Health and Disease INNA SEKIROV, SHANNON L. RUSSELL, L. CAETANO M. ANTUNES, AND B. BRETT FINLAY Michael Smith Laboratories, Department of Microbiology and Immunology, and Department ofBiochemistry
BEST PRACTICES IN SUMMATIVE ASSESSMENT BEST PRACTICES Best practices in summative assessment Jonathan D. Kibble College of Medicine, University of Central Florida, Orlando, Florida Submitted 22 ORGANIZATION FOR PHYSIOLOGICAL HOMEOSTASIS 15 March 2015 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 308, No. 6HOMEPAGE FEATURE
APS members work at the frontiers of science to advance our understanding of life and health. Their efforts are leading to treatments for the deadliest and most debilitating diseases affecting humans and enhancing our understanding of topics like genetics, neuroscience, obesity and sex differences. You can be part of thisvibrant community.
THE PHYSIOLOGY OF COVID-19 Sidebar: APS Journals Highlight COVID-19 Research . The American Physiological Society (APS) journals can serve as a reliable resource to the physiology community during the pandemic by sharing new findings on how coronaviruses affect the body and particular organsystems.
PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
PHYSIOLOGICAL REVIEWS: VOL 101, NO 2 Physiological Reviews Apr 2021 417-738. Cover: Fibroblast growth factors (FGFs) and tyrosine kinase FGF receptors play a key role in the physiopathology of the prostate gland via mutual interactions between mesenchymal and epithelial compartments. FGF signaling is required for prostate development and homeostasis, and its abnormal activation may lead to prostate hyperplasia and FLUID TRANSPORT IN THE BRAIN The blood-brain barrier establishes a stable environment that is optimal for neuronal function, yet the barrier imposes a physiological problem; transcapillary filtration that forms extracellular fluid in other organs is reduced to a minimum in brain. Consequently, the brain depends on a special fluid (the cerebrospinal fluid; CSF) that is EXPERIMENTAL BIOLOGY APS’s annual meeting is held every spring in conjunction with the Experimental Biology (EB) meeting. Five societies (APS, AAA, ASBMB, ASIP and ASPET) jointly sponsor EB. The result is an interdisciplinary, biomedical and scientific meeting featuring a robust lineup plenary and award lectures, symposia, oral and postersessions and career
SEVENTEENTH INTERNATIONAL CONFERENCE ON ENDOTHELIN (ET-17 The American Physiological Society’s (APS) Seventeenth International Conference on Endothelin (ET-17) will be held virtually October 4–7, 2021. Check back often as registration, abstract submission and awards information will be available soon. Sign up for conference announcements to stay in the know. This biennial event is the premier GUT MICROBIOTA IN HEALTH AND DISEASE Gut Microbiota in Health and Disease INNA SEKIROV, SHANNON L. RUSSELL, L. CAETANO M. ANTUNES, AND B. BRETT FINLAY Michael Smith Laboratories, Department of Microbiology and Immunology, and Department ofBiochemistry
BEST PRACTICES IN SUMMATIVE ASSESSMENT BEST PRACTICES Best practices in summative assessment Jonathan D. Kibble College of Medicine, University of Central Florida, Orlando, Florida Submitted 22 ORGANIZATION FOR PHYSIOLOGICAL HOMEOSTASIS 15 March 2015 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 308, No. 6 PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
ADVANCES IN PHYSIOLOGY EDUCATION Advances in Physiology Education promotes and disseminates educational scholarship in order to enhance teaching and learning of physiology, neuroscience and pathophysiology. The journal publishes peer-reviewed descriptions of innovations that improve teaching in the classroom and laboratory, essays on education, and review articles based on our current understanding of physiological mechanisms.APS STAFF DIRECTORY
Editorial & Production. Audra Cox. Publications Director, Editorial & Production. Sean Boyer. Journal Supervisor, Physiological Reviews, Physiology, and Advances in Physiology Education. Bonnie Bright. Journal Supervisor, AJP-Cell Physiology and AJP-Lung Cellular & Molecular Physiology. Zeki Erim. MITOCHONDRIAL METABOLIC MANIPULATION BY SARS-COV-2 IN The COVID-19 pandemic has been the primary global health issue since its outbreak in December 2019. Patients with metabolic syndrome suffer from severe complications and a higher mortality rate due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. JOURNAL OF NEUROPHYSIOLOGY The Journal of Neurophysiology publishes original articles on the function of the nervous system. All levels of function are included, from the membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems REGULATION AND METABOLIC FUNCTIONS OF MTORC1 AND MTORC2 A central signaling molecule that integrates growth with metabolism is the mechanistic target of rapamycin (mTOR). mTOR is a protein kinase that responds to levels of nutrients and growth signals. mTOR forms two protein complexes, mTORC1, which is sensitive to rapamycin and mTORC2, which is not directly inhibited by this drug. EXPERIMENTAL BIOLOGY APS’s annual meeting is held every spring in conjunction with the Experimental Biology (EB) meeting. Five societies (APS, AAA, ASBMB, ASIP and ASPET) jointly sponsor EB. The result is an interdisciplinary, biomedical and scientific meeting featuring a robust lineup plenary and award lectures, symposia, oral and postersessions and career
ORGANIZATION FOR PHYSIOLOGICAL HOMEOSTASIS 15 March 2015 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 308, No. 6 COLD ADAPTATION IN AUSTRALIAN ABORIGINES A field investigation was conducted to study cold acclimation in the Pitjandjara, a desert tribe of Australian aborigines. Oxygen consumption and rectal and skin temperatures were taken every half hour throughout the night a) while the natives were resting naked on the ground between their camp fires and b) while they rested naked without fires in a single-blanket sleeping bag, subjected to a COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. EXPERIMENTAL BIOLOGY 6120 Executive Boulevard, Suite 600 Rockville, MD 20852-4911. Phone: +1 301.634.7164. Fax: +1 301.634.7241 PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging fromasymptomatic
PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
APS STAFF DIRECTORY
Cho Chee Cheung Peer Review & Ethics Coordinator, AJP-Gastrointestinal & Liver Physiology, AJP-Regulatory, Integrative & Comparative Physiology and AJP-Lung Cellular & Molecular Physiology FLUID TRANSPORT IN THE BRAIN Brain harbors a unique ability to, figuratively speaking, shift its gears. During wakefulness, the brain is geared fully towards processing information and behaving, while homeostatic functions pre SEVENTEENTH INTERNATIONAL CONFERENCE ON ENDOTHELIN (ET-17 6120 Executive Boulevard, Suite 600 Rockville, MD 20852-4911. Phone: +1 301.634.7164. Fax: +1 301.634.7241 PHYSIOLOGICAL REVIEWS REVIEW ARTICLE18 II. PHYSIOLOGICAL ADAPTATIONS TO PREGNANCY AND THE IMPLICATIONS FOR COVID-19 A. ImmunologicalResponse COVID-19 is a capsulated single-stranded RNA virus (21). SPINAL AND SUPRASPINAL FACTORS IN HUMAN MUSCLE FATIGUE Spinal and Supraspinal Factors in Human Muscle Fatigue S. C. GANDEVIA Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Sydney, Australia CONCERNING THE RELATIONSHIP BETWEEN THE STRENGTH OF … concerning the relationship between the strength of acids and their capacity to preserve neutrality. lawrence j. henderson COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. EXPERIMENTAL BIOLOGY 6120 Executive Boulevard, Suite 600 Rockville, MD 20852-4911. Phone: +1 301.634.7164. Fax: +1 301.634.7241 PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging fromasymptomatic
PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
APS STAFF DIRECTORY
Cho Chee Cheung Peer Review & Ethics Coordinator, AJP-Gastrointestinal & Liver Physiology, AJP-Regulatory, Integrative & Comparative Physiology and AJP-Lung Cellular & Molecular Physiology FLUID TRANSPORT IN THE BRAIN Brain harbors a unique ability to, figuratively speaking, shift its gears. During wakefulness, the brain is geared fully towards processing information and behaving, while homeostatic functions pre SEVENTEENTH INTERNATIONAL CONFERENCE ON ENDOTHELIN (ET-17 6120 Executive Boulevard, Suite 600 Rockville, MD 20852-4911. Phone: +1 301.634.7164. Fax: +1 301.634.7241 PHYSIOLOGICAL REVIEWS REVIEW ARTICLE18 II. PHYSIOLOGICAL ADAPTATIONS TO PREGNANCY AND THE IMPLICATIONS FOR COVID-19 A. ImmunologicalResponse COVID-19 is a capsulated single-stranded RNA virus (21). SPINAL AND SUPRASPINAL FACTORS IN HUMAN MUSCLE FATIGUE Spinal and Supraspinal Factors in Human Muscle Fatigue S. C. GANDEVIA Prince of Wales Medical Research Institute, Prince of Wales Hospital and University of New South Wales, Sydney, Australia CONCERNING THE RELATIONSHIP BETWEEN THE STRENGTH OF … concerning the relationship between the strength of acids and their capacity to preserve neutrality. lawrence j. henderson EXPERIMENTAL BIOLOGY 6120 Executive Boulevard, Suite 600 Rockville, MD 20852-4911. Phone: +1 301.634.7164. Fax: +1 301.634.7241APS STAFF DIRECTORY
Cho Chee Cheung Peer Review & Ethics Coordinator, AJP-Gastrointestinal & Liver Physiology, AJP-Regulatory, Integrative & Comparative Physiology and AJP-Lung Cellular & Molecular Physiology EXERCISE IS THE REAL POLYPILL Exercise is the Real Polypill The concept of a “polypill” is receiving growing attention to prevent cardio-vascular disease. Yet similar if not overall higher benefits are achievable with SOCIAL ISOLATION DURING THE COVID-19 PANDEMIC CAN INCREASE PERSPECTIVES Integrative Cardiovascular Physiology and Pathophysiology Social isolation during the COVID-19 pandemic can increase physical inactivity and the global burden of cardiovascular disease X Tiago Peçanha,1* Karla Fabiana Goessler,1,2* Hamilton Roschel,1,2 and Bruno Gualano1,2,3 1Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Faculdade GUT MICROBIOTA IN HEALTH AND DISEASE Gut Microbiota in Health and Disease INNA SEKIROV, SHANNON L. RUSSELL, L. CAETANO M. ANTUNES, AND B. BRETT FINLAY Michael Smith Laboratories, Department of Microbiology and Immunology, and Department ofBiochemistry
PATHOPHYSIOLOGY OF MIGRAINE: A DISORDER OF SENSORY … a day of feeling unwell, usually with tiredness called the postdrome (299, 465). Additionally, in approximately one-third of migraine patients, their attacks are associated by A THEORETICAL FOUNDATION FOR DISCOVERY LEARNING The processes of discovery learning are well grounded in current theories of learning. This article describes how cognitive learningtheory supports
BEST PRACTICES IN SUMMATIVE ASSESSMENT BEST PRACTICES Best practices in summative assessment Jonathan D. Kibble College of Medicine, University of Central Florida, Orlando, Florida Submitted 22 AGE-ASSOCIATED CHANGES IN SKELETAL MUSCLES AND THEIR Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia Fulvio Lauretani,1 Cosimo Roberto Russo,1 Stefania Bandinelli,1 Benedetta Bartali,1 Chiara Cavazzini,1 Angelo Di Iorio,2 Anna Maria Corsi,1 Taina Rantanen,3 Jack M. Guralnik,4 and Luigi Ferrucci1,5 1Laboratory of Clinical Epidemiology, Geriatric Department, Italian NationalInstitute of
GLUCOSE TRANSPORTERS IN THE 21ST CENTURY Glucose transporters in the 21st Century Bernard Thorens1 and Mike Mueckler2 1Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; and 2Department of Cell Physiology, Washington University of St. Louis, St. Louis, Missouri Submitted 2 December 2009; accepted in final form 10 December 2009 Thorens B, Mueckler M. COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE24 The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
APS STAFF DIRECTORY
Editorial & Production. Audra Cox. Publications Director, Editorial & Production. Sean Boyer. Journal Supervisor, Physiological Reviews, Physiology, and Advances in Physiology Education. Bonnie Bright. Journal Supervisor, AJP-Cell Physiology and AJP-Lung Cellular & Molecular Physiology. Zeki Erim. PHYSIOLOGICAL REVIEWS REVIEW ARTICLE18 II. PHYSIOLOGICAL ADAPTATIONS TO PREGNANCY AND THE IMPLICATIONS FOR COVID-19 A. ImmunologicalResponse COVID-19 is a capsulated single-stranded RNA virus (21). FLUID TRANSPORT IN THE BRAIN The blood-brain barrier establishes a stable environment that is optimal for neuronal function, yet the barrier imposes a physiological problem; transcapillary filtration that forms extracellular fluid in other organs is reduced to a minimum in brain. Consequently, the brain depends on a special fluid (the cerebrospinal fluid; CSF) that is MITOCHONDRIAL METABOLIC MANIPULATION BY SARS-COV-2 IN6 RESEARCH ARTICLE Virus-Host Cell Interactions and the Viral Life Cycle: Basic Science to Therapeutics Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood BEST PRACTICES IN SUMMATIVE ASSESSMENT BEST PRACTICES Best practices in summative assessment Jonathan D. Kibble College of Medicine, University of Central Florida, Orlando, Florida Submitted 22 CONCERNING THE RELATIONSHIP BETWEEN THE STRENGTH OF … concerning the relationship between the strength of acids and their capacity to preserve neutrality. lawrence j. henderson GLUCOSE TRANSPORTERS IN THE 21ST CENTURY Glucose transporters in the 21st Century Bernard Thorens1 and Mike Mueckler2 1Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; and 2Department of Cell Physiology, Washington University of St. Louis, St. Louis, Missouri Submitted 2 December 2009; accepted in final form 10 December 2009 Thorens B, Mueckler M. COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE24 The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
APS STAFF DIRECTORY
Editorial & Production. Audra Cox. Publications Director, Editorial & Production. Sean Boyer. Journal Supervisor, Physiological Reviews, Physiology, and Advances in Physiology Education. Bonnie Bright. Journal Supervisor, AJP-Cell Physiology and AJP-Lung Cellular & Molecular Physiology. Zeki Erim. PHYSIOLOGICAL REVIEWS REVIEW ARTICLE18 II. PHYSIOLOGICAL ADAPTATIONS TO PREGNANCY AND THE IMPLICATIONS FOR COVID-19 A. ImmunologicalResponse COVID-19 is a capsulated single-stranded RNA virus (21). FLUID TRANSPORT IN THE BRAIN The blood-brain barrier establishes a stable environment that is optimal for neuronal function, yet the barrier imposes a physiological problem; transcapillary filtration that forms extracellular fluid in other organs is reduced to a minimum in brain. Consequently, the brain depends on a special fluid (the cerebrospinal fluid; CSF) that is MITOCHONDRIAL METABOLIC MANIPULATION BY SARS-COV-2 IN6 RESEARCH ARTICLE Virus-Host Cell Interactions and the Viral Life Cycle: Basic Science to Therapeutics Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood BEST PRACTICES IN SUMMATIVE ASSESSMENT BEST PRACTICES Best practices in summative assessment Jonathan D. Kibble College of Medicine, University of Central Florida, Orlando, Florida Submitted 22 CONCERNING THE RELATIONSHIP BETWEEN THE STRENGTH OF … concerning the relationship between the strength of acids and their capacity to preserve neutrality. lawrence j. henderson GLUCOSE TRANSPORTERS IN THE 21ST CENTURY Glucose transporters in the 21st Century Bernard Thorens1 and Mike Mueckler2 1Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; and 2Department of Cell Physiology, Washington University of St. Louis, St. Louis, Missouri Submitted 2 December 2009; accepted in final form 10 December 2009 Thorens B, Mueckler M. COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
APS STAFF DIRECTORY
Editorial & Production. Audra Cox. Publications Director, Editorial & Production. Sean Boyer. Journal Supervisor, Physiological Reviews, Physiology, and Advances in Physiology Education. Bonnie Bright. Journal Supervisor, AJP-Cell Physiology and AJP-Lung Cellular & Molecular Physiology. Zeki Erim. SOCIAL ISOLATION DURING THE COVID-19 PANDEMIC CAN INCREASE PERSPECTIVES Integrative Cardiovascular Physiology and Pathophysiology Social isolation during the COVID-19 pandemic can increase physical inactivity and the global burden of cardiovascular disease X Tiago Peçanha,1* Karla Fabiana Goessler,1,2* Hamilton Roschel,1,2 and Bruno Gualano1,2,3 1Applied Physiology and Nutrition Research Group, School of Physical Education and Sport, Faculdade THE HEALTH BENEFITS OF PASSIVE HEATING AND AEROBIC Exercise can induce numerous health benefits that can reduce the risk of chronic diseases and all-cause mortality, yet a significant percentage of the population do EXPERIMENTAL BIOLOGY APS’s annual meeting is held every spring in conjunction with the Experimental Biology (EB) meeting. Five societies (APS, AAA, ASBMB, ASIP and ASPET) jointly sponsor EB. The result is an interdisciplinary, biomedical and scientific meeting featuring a robust lineup plenary and award lectures, symposia, oral and postersessions and career
GUT MICROBIOTA IN HEALTH AND DISEASE Gut Microbiota in Health and Disease INNA SEKIROV, SHANNON L. RUSSELL, L. CAETANO M. ANTUNES, AND B. BRETT FINLAY Michael Smith Laboratories, Department of Microbiology and Immunology, and Department ofBiochemistry
EXERCISE IS THE REAL POLYPILL Exercise is the Real Polypill The concept of a “polypill” is receiving growing attention to prevent cardio-vascular disease. Yet similar if not overall higher benefits are achievable with A THEORETICAL FOUNDATION FOR DISCOVERY LEARNING The processes of discovery learning are well grounded in current theories of learning. This article describes how cognitive learningtheory supports
BEST PRACTICES IN SUMMATIVE ASSESSMENT BEST PRACTICES Best practices in summative assessment Jonathan D. Kibble College of Medicine, University of Central Florida, Orlando, Florida Submitted 22 COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. MEMBERSHIP & COMMUNITY Membership & Community. The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Join now and get involved. Join APS Renew Your Membership Member Benefits. ADVANCES IN PHYSIOLOGY EDUCATION Advances in Physiology Education promotes and disseminates educational scholarship in order to enhance teaching and learning of physiology, neuroscience and pathophysiology. The journal publishes peer-reviewed descriptions of innovations that improve teaching in the classroom and laboratory, essays on education, and review articles based on our current understanding of physiological mechanisms.APS STAFF DIRECTORY
Editorial & Production. Audra Cox. Publications Director, Editorial & Production. Sean Boyer. Journal Supervisor, Physiological Reviews, Physiology, and Advances in Physiology Education. Bonnie Bright. Journal Supervisor, AJP-Cell Physiology and AJP-Lung Cellular & Molecular Physiology. Zeki Erim. FLUID TRANSPORT IN THE BRAIN The blood-brain barrier establishes a stable environment that is optimal for neuronal function, yet the barrier imposes a physiological problem; transcapillary filtration that forms extracellular fluid in other organs is reduced to a minimum in brain. Consequently, the brain depends on a special fluid (the cerebrospinal fluid; CSF) that is EXPERIMENTAL BIOLOGY APS’s annual meeting is held every spring in conjunction with the Experimental Biology (EB) meeting. Five societies (APS, AAA, ASBMB, ASIP and ASPET) jointly sponsor EB. The result is an interdisciplinary, biomedical and scientific meeting featuring a robust lineup plenary and award lectures, symposia, oral and postersessions and career
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations on the physiology of the heart, blood vessels, and lymphatics, including experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact animal to the cellular, subcellular, andmolecular levels.
GUT MICROBIOTA IN HEALTH AND DISEASE Gut Microbiota in Health and Disease INNA SEKIROV, SHANNON L. RUSSELL, L. CAETANO M. ANTUNES, AND B. BRETT FINLAY Michael Smith Laboratories, Department of Microbiology and Immunology, and Department ofBiochemistry
EXERCISE IS THE REAL POLYPILL Exercise is the Real Polypill The concept of a “polypill” is receiving growing attention to prevent cardio-vascular disease. Yet similar if not overall higher benefits are achievable with MUSCLE CREATINE LOADING IN MEN CREATINE LOADING IN MEN 233 samples were obtained before supplementation (day 0) and on days 7, 21, and 35. The maintenancedose of 2 g/day was
COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. MEMBERSHIP & COMMUNITY Membership & Community. The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Join now and get involved. Join APS Renew Your Membership Member Benefits. ADVANCES IN PHYSIOLOGY EDUCATION Advances in Physiology Education promotes and disseminates educational scholarship in order to enhance teaching and learning of physiology, neuroscience and pathophysiology. The journal publishes peer-reviewed descriptions of innovations that improve teaching in the classroom and laboratory, essays on education, and review articles based on our current understanding of physiological mechanisms.APS STAFF DIRECTORY
Editorial & Production. Audra Cox. Publications Director, Editorial & Production. Sean Boyer. Journal Supervisor, Physiological Reviews, Physiology, and Advances in Physiology Education. Bonnie Bright. Journal Supervisor, AJP-Cell Physiology and AJP-Lung Cellular & Molecular Physiology. Zeki Erim. FLUID TRANSPORT IN THE BRAIN The blood-brain barrier establishes a stable environment that is optimal for neuronal function, yet the barrier imposes a physiological problem; transcapillary filtration that forms extracellular fluid in other organs is reduced to a minimum in brain. Consequently, the brain depends on a special fluid (the cerebrospinal fluid; CSF) that is EXPERIMENTAL BIOLOGY APS’s annual meeting is held every spring in conjunction with the Experimental Biology (EB) meeting. Five societies (APS, AAA, ASBMB, ASIP and ASPET) jointly sponsor EB. The result is an interdisciplinary, biomedical and scientific meeting featuring a robust lineup plenary and award lectures, symposia, oral and postersessions and career
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations on the physiology of the heart, blood vessels, and lymphatics, including experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact animal to the cellular, subcellular, andmolecular levels.
GUT MICROBIOTA IN HEALTH AND DISEASE Gut Microbiota in Health and Disease INNA SEKIROV, SHANNON L. RUSSELL, L. CAETANO M. ANTUNES, AND B. BRETT FINLAY Michael Smith Laboratories, Department of Microbiology and Immunology, and Department ofBiochemistry
EXERCISE IS THE REAL POLYPILL Exercise is the Real Polypill The concept of a “polypill” is receiving growing attention to prevent cardio-vascular disease. Yet similar if not overall higher benefits are achievable with MUSCLE CREATINE LOADING IN MEN CREATINE LOADING IN MEN 233 samples were obtained before supplementation (day 0) and on days 7, 21, and 35. The maintenancedose of 2 g/day was
HOMEPAGE FEATURE
APS members work at the frontiers of science to advance our understanding of life and health. Their efforts are leading to treatments for the deadliest and most debilitating diseases affecting humans and enhancing our understanding of topics like genetics, neuroscience, obesity and sex differences. You can be part of thisvibrant community.
MEMBERSHIP & COMMUNITY Membership & Community. The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Join now and get involved. Join APS Renew Your Membership Member Benefits.MEETINGS & EVENTS
October 4 to October 7, 2021 Seventeenth International Conference on Endothelin (ET-17) This biennial event is the premier forum for scientists to meet and discuss recent research developments in endothelin (ET), clinical applications of blocking the ET system and the use of ET as a biomarker for disease. October 13, 2021 11:00 AM to12:00 PM
PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
MITOCHONDRIAL METABOLIC MANIPULATION BY SARS-COV-2 IN cells to use different substrates to produce energy (10). The three primary substrates that drive the mitochondrial activ-ities are long-chain fatty acids (LCFAs), glucose/pyruvate, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations on the physiology of the heart, blood vessels, and lymphatics, including experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact animal to the cellular, subcellular, andmolecular levels.
JOURNAL OF NEUROPHYSIOLOGY The Journal of Neurophysiology publishes original articles on the function of the nervous system. All levels of function are included, from the membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems MUSCLE CREATINE LOADING IN MEN CREATINE LOADING IN MEN 233 samples were obtained before supplementation (day 0) and on days 7, 21, and 35. The maintenancedose of 2 g/day was
PHYSIOLOGY OF DROWNING: A REVIEW Physiology Of Drowning: A Review Drowning physiology relates to two different events: immersion (upper airway above water) and submersion (upper airway under water). ROLE OF INACTIVITY IN CHRONIC DISEASES: EVOLUTIONARY ROLE OF INACTIVITY IN CHRONIC DISEASES: EVOLUTIONARY INSIGHT AND PATHOPHYSIOLOGICAL MECHANISMS X Frank W. Booth, Christian K. Roberts, John P. Thyfault, Gregory N. Ruegsegger, COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. MEMBERSHIP & COMMUNITY Membership & Community. The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Join now and get involved. Join APS Renew Your Membership Member Benefits. ADVANCES IN PHYSIOLOGY EDUCATION Advances in Physiology Education promotes and disseminates educational scholarship in order to enhance teaching and learning of physiology, neuroscience and pathophysiology. The journal publishes peer-reviewed descriptions of innovations that improve teaching in the classroom and laboratory, essays on education, and review articles based on our current understanding of physiological mechanisms.APS STAFF DIRECTORY
Editorial & Production. Audra Cox. Publications Director, Editorial & Production. Sean Boyer. Journal Supervisor, Physiological Reviews, Physiology, and Advances in Physiology Education. Bonnie Bright. Journal Supervisor, AJP-Cell Physiology and AJP-Lung Cellular & Molecular Physiology. Zeki Erim. FLUID TRANSPORT IN THE BRAIN The blood-brain barrier establishes a stable environment that is optimal for neuronal function, yet the barrier imposes a physiological problem; transcapillary filtration that forms extracellular fluid in other organs is reduced to a minimum in brain. Consequently, the brain depends on a special fluid (the cerebrospinal fluid; CSF) that is MITOCHONDRIAL METABOLIC MANIPULATION BY SARS-COV-2 IN RESEARCH ARTICLE Virus-Host Cell Interactions and the Viral Life Cycle: Basic Science to Therapeutics Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood EXPERIMENTAL BIOLOGY APS’s annual meeting is held every spring in conjunction with the Experimental Biology (EB) meeting. Five societies (APS, AAA, ASBMB, ASIP and ASPET) jointly sponsor EB. The result is an interdisciplinary, biomedical and scientific meeting featuring a robust lineup plenary and award lectures, symposia, oral and postersessions and career
GUT MICROBIOTA IN HEALTH AND DISEASE Gut Microbiota in Health and Disease INNA SEKIROV, SHANNON L. RUSSELL, L. CAETANO M. ANTUNES, AND B. BRETT FINLAY Michael Smith Laboratories, Department of Microbiology and Immunology, and Department ofBiochemistry
EXERCISE IS THE REAL POLYPILL Exercise is the Real Polypill The concept of a “polypill” is receiving growing attention to prevent cardio-vascular disease. Yet similar if not overall higher benefits are achievable with MUSCLE CREATINE LOADING IN MEN CREATINE LOADING IN MEN 233 samples were obtained before supplementation (day 0) and on days 7, 21, and 35. The maintenancedose of 2 g/day was
COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. MEMBERSHIP & COMMUNITY Membership & Community. The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Join now and get involved. Join APS Renew Your Membership Member Benefits. ADVANCES IN PHYSIOLOGY EDUCATION Advances in Physiology Education promotes and disseminates educational scholarship in order to enhance teaching and learning of physiology, neuroscience and pathophysiology. The journal publishes peer-reviewed descriptions of innovations that improve teaching in the classroom and laboratory, essays on education, and review articles based on our current understanding of physiological mechanisms.APS STAFF DIRECTORY
Editorial & Production. Audra Cox. Publications Director, Editorial & Production. Sean Boyer. Journal Supervisor, Physiological Reviews, Physiology, and Advances in Physiology Education. Bonnie Bright. Journal Supervisor, AJP-Cell Physiology and AJP-Lung Cellular & Molecular Physiology. Zeki Erim. FLUID TRANSPORT IN THE BRAIN The blood-brain barrier establishes a stable environment that is optimal for neuronal function, yet the barrier imposes a physiological problem; transcapillary filtration that forms extracellular fluid in other organs is reduced to a minimum in brain. Consequently, the brain depends on a special fluid (the cerebrospinal fluid; CSF) that is MITOCHONDRIAL METABOLIC MANIPULATION BY SARS-COV-2 IN RESEARCH ARTICLE Virus-Host Cell Interactions and the Viral Life Cycle: Basic Science to Therapeutics Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood EXPERIMENTAL BIOLOGY APS’s annual meeting is held every spring in conjunction with the Experimental Biology (EB) meeting. Five societies (APS, AAA, ASBMB, ASIP and ASPET) jointly sponsor EB. The result is an interdisciplinary, biomedical and scientific meeting featuring a robust lineup plenary and award lectures, symposia, oral and postersessions and career
GUT MICROBIOTA IN HEALTH AND DISEASE Gut Microbiota in Health and Disease INNA SEKIROV, SHANNON L. RUSSELL, L. CAETANO M. ANTUNES, AND B. BRETT FINLAY Michael Smith Laboratories, Department of Microbiology and Immunology, and Department ofBiochemistry
EXERCISE IS THE REAL POLYPILL Exercise is the Real Polypill The concept of a “polypill” is receiving growing attention to prevent cardio-vascular disease. Yet similar if not overall higher benefits are achievable with MUSCLE CREATINE LOADING IN MEN CREATINE LOADING IN MEN 233 samples were obtained before supplementation (day 0) and on days 7, 21, and 35. The maintenancedose of 2 g/day was
HOMEPAGE FEATURE
APS members work at the frontiers of science to advance our understanding of life and health. Their efforts are leading to treatments for the deadliest and most debilitating diseases affecting humans and enhancing our understanding of topics like genetics, neuroscience, obesity and sex differences. You can be part of thisvibrant community.
MEMBERSHIP & COMMUNITY Membership & Community. The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Join now and get involved. Join APS Renew Your Membership Member Benefits.MEETINGS & EVENTS
October 4 to October 7, 2021 Seventeenth International Conference on Endothelin (ET-17) This biennial event is the premier forum for scientists to meet and discuss recent research developments in endothelin (ET), clinical applications of blocking the ET system and the use of ET as a biomarker for disease. October 13, 2021 11:00 AM to12:00 PM
PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
SEVENTEENTH INTERNATIONAL CONFERENCE ON ENDOTHELIN (ET-17 The American Physiological Society’s (APS) Seventeenth International Conference on Endothelin (ET-17) will be held virtually October 4–7, 2021. Check back often as registration, abstract submission and awards information will be available soon. Sign up for conference announcements to stay in the know. This biennial event is the premier AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations on the physiology of the heart, blood vessels, and lymphatics, including experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact animal to the cellular, subcellular, andmolecular levels.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND The American Journal of Physiology-Regulatory, Integrative and Comparative Physiology publishes original investigations that illuminate normal or abnormal regulation and integration of physiological mechanisms at all levels of biological organization,ranging
MINI-REVIEW: FIGHT AGAINST FIBROSIS IN ADIPOSE TISSUE Adipose is a key tissue regulating energy homeostasis. In states of obesity, caloric intake exceeds energy expenditure, thereby accelerating lipid accumulation with OBESE ADIPOSE TISSUE MODULATES PRO-INFLAMMATORY RESPONSES Although recognized as an important endocrine organ, little is known about the mechanisms through which adipose tissue can regulate inflammatory responses in distant tissues, such as lung, that are ON THE ENCODING CAPACITY OF HUMAN MOTOR ADAPTATION Primitive-based models of motor learning suggest that adaptation occurs by tuning the responses of motor primitives. Based on this idea, we consider motor learning as an information encoding proced COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE22 The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. MEMBERSHIP & COMMUNITY Membership & Community. The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Join now and get involved. Join APS Renew Your Membership Member Benefits.APS STAFF DIRECTORY
Editorial & Production. Audra Cox. Publications Director, Editorial & Production. Sean Boyer. Journal Supervisor, Physiological Reviews, Physiology, and Advances in Physiology Education. Bonnie Bright. Journal Supervisor, AJP-Cell Physiology and AJP-Lung Cellular & Molecular Physiology. Zeki Erim. OBESITY CARDIOMYOPATHY: EVIDENCE, MECHANISMS AND To this point, epidemiological, clinical and experimental evidence supports the existence of a unique disease entity termed "obesity cardiomyopathy", which develops independent of hypertension, coronary heart disease and other heart diseases. Our contemporary review evaluates the evidence for this pathological condition, examinesputative
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR The American Journal of Physiology-Lung Cellular and Molecular Physiology publishes original research covering the broad scope of molecular, cellular, and integrative aspects of normal and abnormal function of cells and components of the respiratory system. Areas of interest include conducting airways, pulmonary circulation, lung endothelial and epithelial cells, the pleura, neuroendocrine and AGE-ASSOCIATED CHANGES IN SKELETAL MUSCLES AND THEIR Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia Fulvio Lauretani,1 Cosimo Roberto Russo,1 Stefania Bandinelli,1 Benedetta Bartali,1 Chiara Cavazzini,1 Angelo Di Iorio,2 Anna Maria Corsi,1 Taina Rantanen,3 Jack M. Guralnik,4 and Luigi Ferrucci1,5 1Laboratory of Clinical Epidemiology, Geriatric Department, Italian NationalInstitute of
ABOUT AJP-HEART
About American Journal of Physiology-Heart and Circulatory Physiology. The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations, reviews and perspectives on the physiology of the heart, vasculature, and lymphatics. These articles include experimental and theoretical studies of cardiovascular function at all levels of organization ranging MUSCLE CREATINE LOADING IN MEN CREATINE LOADING IN MEN 233 samples were obtained before supplementation (day 0) and on days 7, 21, and 35. The maintenancedose of 2 g/day was
GLUCOSE TRANSPORTERS IN THE 21ST CENTURY Glucose transporters in the 21st Century Bernard Thorens1 and Mike Mueckler2 1Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; and 2Department of Cell Physiology, Washington University of St. Louis, St. Louis, Missouri Submitted 2 December 2009; accepted in final form 10 December 2009 Thorens B, Mueckler M. COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE22 The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. MEMBERSHIP & COMMUNITY Membership & Community. The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Join now and get involved. Join APS Renew Your Membership Member Benefits.APS STAFF DIRECTORY
Editorial & Production. Audra Cox. Publications Director, Editorial & Production. Sean Boyer. Journal Supervisor, Physiological Reviews, Physiology, and Advances in Physiology Education. Bonnie Bright. Journal Supervisor, AJP-Cell Physiology and AJP-Lung Cellular & Molecular Physiology. Zeki Erim. OBESITY CARDIOMYOPATHY: EVIDENCE, MECHANISMS AND To this point, epidemiological, clinical and experimental evidence supports the existence of a unique disease entity termed "obesity cardiomyopathy", which develops independent of hypertension, coronary heart disease and other heart diseases. Our contemporary review evaluates the evidence for this pathological condition, examinesputative
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR The American Journal of Physiology-Lung Cellular and Molecular Physiology publishes original research covering the broad scope of molecular, cellular, and integrative aspects of normal and abnormal function of cells and components of the respiratory system. Areas of interest include conducting airways, pulmonary circulation, lung endothelial and epithelial cells, the pleura, neuroendocrine and AGE-ASSOCIATED CHANGES IN SKELETAL MUSCLES AND THEIR Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia Fulvio Lauretani,1 Cosimo Roberto Russo,1 Stefania Bandinelli,1 Benedetta Bartali,1 Chiara Cavazzini,1 Angelo Di Iorio,2 Anna Maria Corsi,1 Taina Rantanen,3 Jack M. Guralnik,4 and Luigi Ferrucci1,5 1Laboratory of Clinical Epidemiology, Geriatric Department, Italian NationalInstitute of
ABOUT AJP-HEART
About American Journal of Physiology-Heart and Circulatory Physiology. The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations, reviews and perspectives on the physiology of the heart, vasculature, and lymphatics. These articles include experimental and theoretical studies of cardiovascular function at all levels of organization ranging MUSCLE CREATINE LOADING IN MEN CREATINE LOADING IN MEN 233 samples were obtained before supplementation (day 0) and on days 7, 21, and 35. The maintenancedose of 2 g/day was
GLUCOSE TRANSPORTERS IN THE 21ST CENTURY Glucose transporters in the 21st Century Bernard Thorens1 and Mike Mueckler2 1Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; and 2Department of Cell Physiology, Washington University of St. Louis, St. Louis, Missouri Submitted 2 December 2009; accepted in final form 10 December 2009 Thorens B, Mueckler M. MEMBERSHIP & COMMUNITY Membership & Community. The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. Join now and get involved. Join APS Renew Your Membership Member Benefits. ADVANCES IN PHYSIOLOGY EDUCATION Advances in Physiology Education promotes and disseminates educational scholarship in order to enhance teaching and learning of physiology, neuroscience and pathophysiology. The journal publishes peer-reviewed descriptions of innovations that improve teaching in the classroom and laboratory, essays on education, and review articles based on our current understanding of physiological mechanisms. JOURNAL OF APPLIED PHYSIOLOGY The Journal of Applied Physiology publishes original papers that deal with diverse areas of research in applied physiology, especially those papers emphasizing adaptive and integrative mechanisms. Adaptive physiology includes 1) inherent adaptations such as those related to development, aging, and pathophysiological conditions and 2) adaptations to the external environment PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE membrane fusion, requiring S-protein priming or cleavage by host cell proteases or transmembrane serine proteases (9, 10, 90, 94, 108).Indeed, Hoff-
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR The American Journal of Physiology-Lung Cellular and Molecular Physiology publishes original research covering the broad scope of molecular, cellular, and integrative aspects of normal and abnormal function of cells and components of the respiratory system. Areas of interest include conducting airways, pulmonary circulation, lung endothelial and epithelial cells, the pleura, neuroendocrine and FLUID TRANSPORT IN THE BRAIN The blood-brain barrier establishes a stable environment that is optimal for neuronal function, yet the barrier imposes a physiological problem; transcapillary filtration that forms extracellular fluid in other organs is reduced to a minimum in brain. Consequently, the brain depends on a special fluid (the cerebrospinal fluid; CSF) that is AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY The American Journal of Physiology-Renal Physiology publishes original manuscripts on timely topics in both basic science and clinical research. Published articles address a broad range of subjects relating to the kidney and urinary tract, and may involve human or animal models, individual cell types, and isolated membrane systems. EXPERIMENTAL BIOLOGY APS’s annual meeting is held every spring in conjunction with the Experimental Biology (EB) meeting. Five societies (APS, AAA, ASBMB, ASIP and ASPET) jointly sponsor EB. The result is an interdisciplinary, biomedical and scientific meeting featuring a robust lineup plenary and award lectures, symposia, oral and postersessions and career
INTEGRATIVE PHYSIOLOGY OF PNEUMONIA nia is an acute event, it is prompted by preexisting chronic conditions, and it has long-term consequences. Thus pneu-monia is an acute lower respiratory tract infection that is A THEORETICAL FOUNDATION FOR DISCOVERY LEARNING The processes of discovery learning are well grounded in current theories of learning. This article describes how cognitive learningtheory supports
HOMEPAGE FEATURE
APS is a global leader in expanding knowledge related to biological function. We connect a multidisciplinary community of nearly 10,000 scientists and educators from around the world. COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging fromasymptomatic
APS STAFF DIRECTORY
Cho Chee Cheung Peer Review & Ethics Coordinator, AJP-Gastrointestinal & Liver Physiology, AJP-Regulatory, Integrative & Comparative Physiology and AJP-Lung Cellular & Molecular Physiology OBESITY CARDIOMYOPATHY: EVIDENCE, MECHANISMS AND 3School of Medicine, grid.39436.3bShanghai University, Shanghai 200444 China. 4College of Health Sciences, grid.135963.bUniversity of Wyoming, Laramie, WY 82071 USA AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR The American Journal of Physiology-Lung Cellular and Molecular Physiology publishes original research covering the broad scope of molecular, cellular, and integrative aspects of normal and abnormal function of cells and components of the respiratory system. Areas of interest include conducting airways, pulmonary circulation, lung endothelial and epithelial cells, the pleura, neuroendocrine and AGE-ASSOCIATED CHANGES IN SKELETAL MUSCLES AND THEIR Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia Fulvio Lauretani,1 Cosimo Roberto Russo,1 Stefania Bandinelli,1 Benedetta Bartali,1 Chiara Cavazzini,1 Angelo Di Iorio,2 Anna Maria Corsi,1 Taina Rantanen,3 Jack M. Guralnik,4 and Luigi Ferrucci1,5 1Laboratory of Clinical Epidemiology, Geriatric Department, Italian NationalInstitute of
MUSCLE CREATINE LOADING IN MEN CREATINE LOADING IN MEN 233 samples were obtained before supplementation (day 0) and on days 7, 21, and 35. The maintenancedose of 2 g/day was
INTEGRATIVE PHYSIOLOGY OF PNEUMONIA nia is an acute event, it is prompted by preexisting chronic conditions, and it has long-term consequences. Thus pneu-monia is an acute lower respiratory tract infection that is GLUCOSE TRANSPORTERS IN THE 21ST CENTURY Glucose transporters in the 21st Century Bernard Thorens1 and Mike Mueckler2 1Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; and 2Department of Cell Physiology, Washington University of St. Louis, St. Louis, Missouri Submitted 2 December 2009; accepted in final form 10 December 2009 Thorens B, Mueckler M.HOMEPAGE FEATURE
APS is a global leader in expanding knowledge related to biological function. We connect a multidisciplinary community of nearly 10,000 scientists and educators from around the world. COMPREHENSIVE PHYSIOLOGY Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information that has ever been assembled.Its starting point is more than 30,000 pages of content from the American Physiological Society's renowned Handbook of Physiology (HoP) series, which is presented here for the first time in an online format. PATHOPHYSIOLOGY OF COVID-19: MECHANISMS UNDERLYING DISEASE The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging fromasymptomatic
APS STAFF DIRECTORY
Cho Chee Cheung Peer Review & Ethics Coordinator, AJP-Gastrointestinal & Liver Physiology, AJP-Regulatory, Integrative & Comparative Physiology and AJP-Lung Cellular & Molecular Physiology OBESITY CARDIOMYOPATHY: EVIDENCE, MECHANISMS AND 3School of Medicine, grid.39436.3bShanghai University, Shanghai 200444 China. 4College of Health Sciences, grid.135963.bUniversity of Wyoming, Laramie, WY 82071 USA AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR The American Journal of Physiology-Lung Cellular and Molecular Physiology publishes original research covering the broad scope of molecular, cellular, and integrative aspects of normal and abnormal function of cells and components of the respiratory system. Areas of interest include conducting airways, pulmonary circulation, lung endothelial and epithelial cells, the pleura, neuroendocrine and AGE-ASSOCIATED CHANGES IN SKELETAL MUSCLES AND THEIR Age-associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia Fulvio Lauretani,1 Cosimo Roberto Russo,1 Stefania Bandinelli,1 Benedetta Bartali,1 Chiara Cavazzini,1 Angelo Di Iorio,2 Anna Maria Corsi,1 Taina Rantanen,3 Jack M. Guralnik,4 and Luigi Ferrucci1,5 1Laboratory of Clinical Epidemiology, Geriatric Department, Italian NationalInstitute of
MUSCLE CREATINE LOADING IN MEN CREATINE LOADING IN MEN 233 samples were obtained before supplementation (day 0) and on days 7, 21, and 35. The maintenancedose of 2 g/day was
INTEGRATIVE PHYSIOLOGY OF PNEUMONIA nia is an acute event, it is prompted by preexisting chronic conditions, and it has long-term consequences. Thus pneu-monia is an acute lower respiratory tract infection that is GLUCOSE TRANSPORTERS IN THE 21ST CENTURY Glucose transporters in the 21st Century Bernard Thorens1 and Mike Mueckler2 1Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; and 2Department of Cell Physiology, Washington University of St. Louis, St. Louis, Missouri Submitted 2 December 2009; accepted in final form 10 December 2009 Thorens B, Mueckler M.HOMEPAGE FEATURE
A Community of Discovery. APS members work at the frontiers of science to advance our understanding of life and health. Their efforts are leading to treatments for the deadliest and most debilitating diseases affecting humans and enhancing our understanding of topics like genetics, neuroscience, obesity and sex differences. MEMBERSHIP & COMMUNITY The American Physiological Society connects a multidisciplinary community of scientists and educators from around the world, driving collaboration and spotlighting scientific discoveries in physiology and related disciplines. ADVANCES IN PHYSIOLOGY EDUCATION Advances in Physiology Education promotes and disseminates educational scholarship in order to enhance teaching and learning of physiology, neuroscience and pathophysiology. The journal publishes peer-reviewed descriptions of innovations that improve teaching in the classroom and laboratory, essays on education, and review articles based on our current understanding of physiological mechanisms. COVID-19-ASSOCIATED SIADH: A CLUE IN THE TIMES OF PANDEMIC Pulmonary involvement in the form of pneumonia is prevalent among COVID-19-infected individuals as depicted by our cases, and the emerging literature ().The mechanism of SIADH in pneumonia is not well established; however, animal models determined the role of low intravascular fluid volume and low extracellular fluid osmolality (12, 16).In the setting of intravascular volume depletion FLUID TRANSPORT IN THE BRAIN Brain harbors a unique ability to, figuratively speaking, shift its gears. During wakefulness, the brain is geared fully towards processing information and behaving, while homeostatic functions pre EXPERIMENTAL BIOLOGY 6120 Executive Boulevard, Suite 600 Rockville, MD 20852-4911. Phone: +1 301.634.7164. Fax: +1 301.634.7241 A THEORETICAL FOUNDATION FOR DISCOVERY LEARNING The processes of discovery learning are well grounded in current theories of learning. This article describes how cognitive learningtheory supports
PGC-1Α: A KEY REGULATOR OF ENERGY METABOLISM Staying Current PGC-1 : a key regulator of energy metabolism Huiyun Liang1,2 and Walter F. Ward2,3 1Department of Cellular and Structural Biology, 2Barshop Institute for Longevity and Aging Studies, and 3Department of Physiology, Audie Murphy Veterans Administration Medical Center and University of Texas Health Science Center, SanAntonio, Texas
WHERE'S THE EVIDENCE THAT ACTIVE LEARNING WORKS? ceedings, which in the fields discussed here are very common, have been included). I have also tried to identify monographs and review articles that are particularly relevant, but I have also GLUCOSE TRANSPORTERS IN THE 21ST CENTURY Glucose transporters in the 21st Century Bernard Thorens1 and Mike Mueckler2 1Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; and 2Department of Cell Physiology, Washington University of St. Louis, St. Louis, Missouri Submitted 2 December 2009; accepted in final form 10 December 2009 Thorens B, Mueckler M.Menu
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BARBARA E. GOODMAN, PHD, FAPS PROFESSOR, DIVISION OF BIOMEDICAL SCIENCES OF SANFORD SCHOOL OF MEDICINE, UNIVERSITY OF SOUTH DAKOTA INVERMILLION
Fostering Better Physiology Education Using evidence-based pedagogy to enhance physiology education. More on Barb's research.*
JAN M. WILLIAMS, PHD PROFESSOR AND GRADUATE PROGRAM DIRECTOR, UNIVERSITY OF MISSISSIPPI MEDICAL CENTER IN JACKSON Studying Renal Disease Origins in Kids Exploring the consequences of childhood obesity on the kidneys. More on Jan's research.*
MELISSA BATES, PHD ASSOCIATE PROFESSOR OF HEALTH AND HUMAN PHYSIOLOGY, INTERNAL MEDICINE AND PEDIATRICS, UNIVERSITY OF IOWA Exploring how Early Life Affects Later Stress Understanding how medical events and their treatment alter people’sbodies.
More on Melissa's research. PHYSIOLOGY IN THE NEWS*
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