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WORKING WITH US
Beginning with a study design consult, we set the stage for a successful study. Then, we offer guidance and tools for proper sample collection with the support of our Metabolon Study Success Sample Handling Kit. Once samples have gone through our laboratory process, reports may be visualized in the MyMetabolon portal. ENLIGHTENING LIFE™ The Metabolon rebranding effort involved 12-months of in-house brand research and creative strategy. It drew on cross-functional expertise within the organization to articulate the unique value of Precision Metabolomics ™ in expanding and accelerating discoveries across life sciences research. This process culminated in an encompassing corporate vision to guide our rebrand: MetabolonGLOBAL METABOLOMICS
Actionable insights that drive discovery. Metabolon’s Precision Metabolomics™ LC-MS global metabolomics platform provides a high-fidelity, reproducible analysis of the current-state of a biological system to help identify pharmacodynamic, efficacy and response biomarkers and reveal changes in key biological pathways.CAREERS - METABOLON
Careers. A Phenomenal Culture. We’re on a mission to deliver metabolomics data and insights that expand and accelerate the impact of life sciences research in all its applications. Vinay Pawar, Ph.D. Application Scientist, International. Kari Wong, Ph.D. Associate Director, Discovery & OMNIMET·GUT: AT-HOME COLLECTION MADE EASY Validated for Metabolon’s global metabolomics and short chain fatty acid targeted assay. Our validation studies have shown OMNImet·GUT protects and preserves the metabolomic profile of collected samples up to 4 days at room temperature for Metabolon’s Global platform, while short-chain fatty acid (SFCA) profiles are maintained for up to 7TARGETED ASSAYS
Targeted assays are a valuable tool for rapidly and accurately establishing pharmacodynamics, translational studies, gauging efficacy and safety, and post-market surveillance studies. With several different sample matrices supported, deeper insights can be gained in various applications including microbiome research and bioprocessing. FREE FATTY ACID PANEL Free Fatty Acids Fatty acids play many physiologically important roles in an organism. They are not only key metabolites of energy storage and production but also the basicACYLCARNITINE PANEL
Acylcarnitines Acylcarnitines (AC) are formed from acyl-CoA and carnitine by carnitine acyltranferases. They are generally considered the transport form of fatty METABOLON – ENLIGHTENING LIFEMETABOLOMICSSOLUTIONSINSIGHTSRESOURCESCOMPANYOUR PROCESS Metabolon – Enlightening Life. COMPANY NEWS. Metabolon collaborates with Cleveland Clinic to enable novel discoveries. “Metabolomics is an essential element of the multi-omics approach that is being employed by Cleveland Clinic to transform healthcare by understanding disease progression and therapeutic response more deeply.”. ABOUT US - METABOLON About Us. Working With Metabolon. Our work measures inputs from internal and external factors such as health, disease, nutrition, microbiome, medication, pollution, and more, to drive success in answering scientific questions about health and disease. Every day, we accelerate research that leads to successes in biopharma, populationhealth
WORKING WITH US
Beginning with a study design consult, we set the stage for a successful study. Then, we offer guidance and tools for proper sample collection with the support of our Metabolon Study Success Sample Handling Kit. Once samples have gone through our laboratory process, reports may be visualized in the MyMetabolon portal. ENLIGHTENING LIFE™ The Metabolon rebranding effort involved 12-months of in-house brand research and creative strategy. It drew on cross-functional expertise within the organization to articulate the unique value of Precision Metabolomics ™ in expanding and accelerating discoveries across life sciences research. This process culminated in an encompassing corporate vision to guide our rebrand: MetabolonGLOBAL METABOLOMICS
Actionable insights that drive discovery. Metabolon’s Precision Metabolomics™ LC-MS global metabolomics platform provides a high-fidelity, reproducible analysis of the current-state of a biological system to help identify pharmacodynamic, efficacy and response biomarkers and reveal changes in key biological pathways.CAREERS - METABOLON
Careers. A Phenomenal Culture. We’re on a mission to deliver metabolomics data and insights that expand and accelerate the impact of life sciences research in all its applications. Vinay Pawar, Ph.D. Application Scientist, International. Kari Wong, Ph.D. Associate Director, Discovery & OMNIMET·GUT: AT-HOME COLLECTION MADE EASY Validated for Metabolon’s global metabolomics and short chain fatty acid targeted assay. Our validation studies have shown OMNImet·GUT protects and preserves the metabolomic profile of collected samples up to 4 days at room temperature for Metabolon’s Global platform, while short-chain fatty acid (SFCA) profiles are maintained for up to 7TARGETED ASSAYS
Targeted assays are a valuable tool for rapidly and accurately establishing pharmacodynamics, translational studies, gauging efficacy and safety, and post-market surveillance studies. With several different sample matrices supported, deeper insights can be gained in various applications including microbiome research and bioprocessing. FREE FATTY ACID PANEL Free Fatty Acids Fatty acids play many physiologically important roles in an organism. They are not only key metabolites of energy storage and production but also the basicACYLCARNITINE PANEL
Acylcarnitines Acylcarnitines (AC) are formed from acyl-CoA and carnitine by carnitine acyltranferases. They are generally considered the transport form of fattyGET STARTED
Demo Our Data. The MyMetabolon Client Portal gives you on-demand access to your data through an always-on digital portal. This seamless access to your study results allows you to interrogate, analyze and create custom displays with your data when you want and how you want, to ensure you are getting the information you need to advance yourstudy
OUR PROCESS
Analysis. Precisely powerful platform. Metabolon’s global Precision Metabolomics™ LC-MS platform can help reveal detect more unique metabolites than any other platform. Curation. Rise above the noise. Voluminous metabolomics data sets are often riddled with noisy ion features. Our highly trained curation staff has the skills andtechnical
GLOBAL METABOLOMICS
Actionable insights that drive discovery. Metabolon’s Precision Metabolomics™ LC-MS global metabolomics platform provides a high-fidelity, reproducible analysis of the current-state of a biological system to help identify pharmacodynamic, efficacy and response biomarkers and reveal changes in key biological pathways. MICROBIOME - METABOLON Metabolon’s global metabolomics platform provides a full view on host metabolism, xenobiotics, dietary metabolites and novel metabolites produced by the microbiome to guide which microbes and pathways to focus on for the desired therapeutic effect. Leverage the power of focused quantification. Select from a series of targetedassay panels to
TARGETED ASSAYS
Targeted assays are a valuable tool for rapidly and accurately establishing pharmacodynamics, translational studies, gauging efficacy and safety, and post-market surveillance studies. With several different sample matrices supported, deeper insights can be gained in various applications including microbiome research and bioprocessing. LIPIDOMICS - METABOLON Metabolon has overcome the challenges of lipid profiling to create the only platform able to provide both complete and quantitative lipidomic analysis. As complex lipids play an important role in the development of many diseases and disorders, accurate identification and quantification are essential for biomarker discovery and otherbiological
RENAL & UROLOGICAL DISORDERS The burden of renal and urological disease is increasing as U.S. and global populations age. Metabolomics is uniquely poised to drive the needed research and development to fuel greater understanding of these conditions and drive diagnostic and therapeutic opportunities. FREE FATTY ACID PANEL Free Fatty Acids Fatty acids play many physiologically important roles in an organism. They are not only key metabolites of energy storage and production but also the basic COMPARISON OF METABOLOMIC PROFILES IN PLASMA VERSUS DRIED Metabolon, Inc. 617 Davis Drive, Suite 100, Morrisville, NC 27560 © 2020 Metabolon, Inc. All rights reserved. - 1 - Comparison of metabolomic profiles in plasma versus STOOL SAMPLE COLLECTION: A BOTTLENECK TO GUT MICROBIOME Stool Sample Collection: A Bottleneck to Gut Microbiome Research. in Microbiome, Population Health. Our gut microbiota is rich with biological insights, which can help clinical investigators better understand factors that influence both sickness and health. But despite its huge importance, this area of research is plagued bychallenges.
METABOLON – ENLIGHTENING LIFEMETABOLOMICSSOLUTIONSINSIGHTSRESOURCESCOMPANYOUR PROCESS Metabolon – Enlightening Life. COMPANY NEWS. Metabolon collaborates with Cleveland Clinic to enable novel discoveries. “Metabolomics is an essential element of the multi-omics approach that is being employed by Cleveland Clinic to transform healthcare by understanding disease progression and therapeutic response more deeply.”. ABOUT US - METABOLON About Us. Working With Metabolon. Our work measures inputs from internal and external factors such as health, disease, nutrition, microbiome, medication, pollution, and more, to drive success in answering scientific questions about health and disease. Every day, we accelerate research that leads to successes in biopharma, populationhealth
WORKING WITH US
Beginning with a study design consult, we set the stage for a successful study. Then, we offer guidance and tools for proper sample collection with the support of our Metabolon Study Success Sample Handling Kit. Once samples have gone through our laboratory process, reports may be visualized in the MyMetabolon portal. ENLIGHTENING LIFE™ The Metabolon rebranding effort involved 12-months of in-house brand research and creative strategy. It drew on cross-functional expertise within the organization to articulate the unique value of Precision Metabolomics ™ in expanding and accelerating discoveries across life sciences research. This process culminated in an encompassing corporate vision to guide our rebrand: Metabolon LEADERSHIP - METABOLON Michael Rasche. President and General Manager, International Business. As President and General Manager of Metabolon’s international business, Mr. Rasche and his team drive business expansion outside of North America. Mr. Rasche holds a degree in Business Administration from Bayer University. Greg Michelotti, Ph.D.CAREERS - METABOLON
Careers. A Phenomenal Culture. We’re on a mission to deliver metabolomics data and insights that expand and accelerate the impact of life sciences research in all its applications. Vinay Pawar, Ph.D. Application Scientist, International. Kari Wong, Ph.D. Associate Director, Discovery &TARGETED ASSAYS
Targeted assays are a valuable tool for rapidly and accurately establishing pharmacodynamics, translational studies, gauging efficacy and safety, and post-market surveillance studies. With several different sample matrices supported, deeper insights can be gained in various applications including microbiome research and bioprocessing. FREE FATTY ACID PANEL Free Fatty Acids Fatty acids play many physiologically important roles in an organism. They are not only key metabolites of energy storage and production but also the basic TIER 1 METABOLITE IDENTIFICATIONS: A COMPASS TO RICH This approach to untargeted metabolomics means that all metabolite annotations meet the stringent criteria required for a Tier 1 or 2 identification. Our method stands in stark contrast to the more traditional metabolomics workflow in which the individual ion features, the instrument signal from a mass spectrometer, undergo statistical analysis. WHY DO SOME PEOPLE RESPOND TO CANCER THERAPY WHILE OTHERS While cancer is a genetic disease, response to therapy is not as systematic or clear-cut as simply matching a mutation to treatment. Other factors are clearly involved. Recent work in both mice and humans suggests that one answer may involve the microbiome. Martin Hornshaw, PhD. Director, Scientific Marketing — Metabolon, Inc. METABOLON – ENLIGHTENING LIFEMETABOLOMICSSOLUTIONSINSIGHTSRESOURCESCOMPANYOUR PROCESS Metabolon – Enlightening Life. COMPANY NEWS. Metabolon collaborates with Cleveland Clinic to enable novel discoveries. “Metabolomics is an essential element of the multi-omics approach that is being employed by Cleveland Clinic to transform healthcare by understanding disease progression and therapeutic response more deeply.”. ABOUT US - METABOLON About Us. Working With Metabolon. Our work measures inputs from internal and external factors such as health, disease, nutrition, microbiome, medication, pollution, and more, to drive success in answering scientific questions about health and disease. Every day, we accelerate research that leads to successes in biopharma, populationhealth
WORKING WITH US
Beginning with a study design consult, we set the stage for a successful study. Then, we offer guidance and tools for proper sample collection with the support of our Metabolon Study Success Sample Handling Kit. Once samples have gone through our laboratory process, reports may be visualized in the MyMetabolon portal. ENLIGHTENING LIFE™ The Metabolon rebranding effort involved 12-months of in-house brand research and creative strategy. It drew on cross-functional expertise within the organization to articulate the unique value of Precision Metabolomics ™ in expanding and accelerating discoveries across life sciences research. This process culminated in an encompassing corporate vision to guide our rebrand: Metabolon LEADERSHIP - METABOLON Michael Rasche. President and General Manager, International Business. As President and General Manager of Metabolon’s international business, Mr. Rasche and his team drive business expansion outside of North America. Mr. Rasche holds a degree in Business Administration from Bayer University. Greg Michelotti, Ph.D.CAREERS - METABOLON
Careers. A Phenomenal Culture. We’re on a mission to deliver metabolomics data and insights that expand and accelerate the impact of life sciences research in all its applications. Vinay Pawar, Ph.D. Application Scientist, International. Kari Wong, Ph.D. Associate Director, Discovery &TARGETED ASSAYS
Targeted assays are a valuable tool for rapidly and accurately establishing pharmacodynamics, translational studies, gauging efficacy and safety, and post-market surveillance studies. With several different sample matrices supported, deeper insights can be gained in various applications including microbiome research and bioprocessing. FREE FATTY ACID PANEL Free Fatty Acids Fatty acids play many physiologically important roles in an organism. They are not only key metabolites of energy storage and production but also the basic TIER 1 METABOLITE IDENTIFICATIONS: A COMPASS TO RICH This approach to untargeted metabolomics means that all metabolite annotations meet the stringent criteria required for a Tier 1 or 2 identification. Our method stands in stark contrast to the more traditional metabolomics workflow in which the individual ion features, the instrument signal from a mass spectrometer, undergo statistical analysis. WHY DO SOME PEOPLE RESPOND TO CANCER THERAPY WHILE OTHERS While cancer is a genetic disease, response to therapy is not as systematic or clear-cut as simply matching a mutation to treatment. Other factors are clearly involved. Recent work in both mice and humans suggests that one answer may involve the microbiome. Martin Hornshaw, PhD. Director, Scientific Marketing — Metabolon, Inc.GET STARTED
Demo Our Data. The MyMetabolon Client Portal gives you on-demand access to your data through an always-on digital portal. This seamless access to your study results allows you to interrogate, analyze and create custom displays with your data when you want and how you want, to ensure you are getting the information you need to advance yourstudy
SOLUTIONS - METABOLON Our work measures inputs from internal and external factors such as health, disease, nutrition, microbiome, medication, pollution, and more, to drive success in answering scientific questions about health and disease. Our global metabolomics platform provides a high-fidelity, reproducible analysis of the current state of abiological system.
OUR PROCESS
Analysis. Precisely powerful platform. Metabolon’s global Precision Metabolomics™ LC-MS platform can help reveal detect more unique metabolites than any other platform. Curation. Rise above the noise. Voluminous metabolomics data sets are often riddled with noisy ion features. Our highly trained curation staff has the skills andtechnical
GLOBAL METABOLOMICS
Actionable insights that drive discovery. Metabolon’s Precision Metabolomics™ LC-MS global metabolomics platform provides a high-fidelity, reproducible analysis of the current-state of a biological system to help identify pharmacodynamic, efficacy and response biomarkers and reveal changes in key biological pathways. SAMPLE PREPARATION & HANDLING Sample Preparation & Handling. Quality standards from the start. Metabolon’s commitment to the success of your study is centered on our proven sample preparation and handling methods. Our experience protecting the integrity of metabolite samples for the most accurate and reproducible results is unmatched and led to the development ofthe
TARGETED ASSAYS
Targeted assays are a valuable tool for rapidly and accurately establishing pharmacodynamics, translational studies, gauging efficacy and safety, and post-market surveillance studies. With several different sample matrices supported, deeper insights can be gained in various applications including microbiome research and bioprocessing. BIOTECH / PHARMACEUTICAL Biotech / Pharmaceutical. Functional insights for informed decision making. Over the last decade, the biopharmaceutical industry has seen a rapid increase in costs combined with a dramatic drop in returns on R&D investment. The cause of most program failures or delays is an incomplete understanding of the behavior and impact of drug candidates FREE FATTY ACID PANEL Free Fatty Acids Fatty acids play many physiologically important roles in an organism. They are not only key metabolites of energy storage and production but also the basic OMNIMET·GUT: AT-HOME COLLECTION MADE EASY Validated for Metabolon’s global metabolomics and short chain fatty acid targeted assay. Our validation studies have shown OMNImet·GUT protects and preserves the metabolomic profile of collected samples up to 4 days at room temperature for Metabolon’s Global platform, while short-chain fatty acid (SFCA) profiles are maintained for up to 7ACYLCARNITINE PANEL
Acylcarnitines Acylcarnitines (AC) are formed from acyl-CoA and carnitine by carnitine acyltranferases. They are generally considered the transport form of fatty* Metabolomics
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2020 Metabolon, Inc. All rights reserved.* Metabolomics
* About Metabolomics* Our Process
* Technology & Knowledgebase* Quality Assurance
* Setting the Standard: The 4Cs * Our Latest Insights* Solutions
* Column 1
* Products & Services * Global Metabolomics* Lipidomics
* Targeted Assays
* Microbiome
* Study Design & Consulting * Sample Preparation & Handling * Study Success Sample Handling Kit * Reporting & Interpretation* Bioinformatics
* MyMetabolon Client Portal* Column 2
* By Research & Development Phase * Discovery & Target Selection * Lead Candidate Selection* Preclinical
* Clinical Development * Manufacturing & Bioprocessing* Column 3
* By Therapeutic Area * Cardiovascular Disease* COVID-19
* Diabetes
* Gastrointestinal
* Liver Disease
* Neuroscience
* Oncology
* Renal & Urological Disorders * Respiratory Disorders* Column 4
* By Sector
* Academic
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* Biotech / Pharmaceutical * Precision Medicine* Nutrition
* Personal Care & Cosmetics* Population Health
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Metabolon & Cleveland ClinicNIAIDMicrobiomeScience Goes On COMPANYNEWS
METABOLON COLLABORATES WITH CLEVELAND CLINIC TO ENABLE NOVELDISCOVERIES
“Metabolomics is an essential element of the multi-omics approach that is being employed by Cleveland Clinic to transform healthcare by understanding disease progression and therapeutic response moredeeply.”
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COVID-19
ADVANCING NIAID’S
CRITICAL WORK
“We are honored to partner with NIAID and Metabolon in this effort to define how the human response to SARS-CoV-2 correlates to COVID severity and outcome.” – Dr. Ofer Levy, Director of the Precision Vaccines Program (PVP) at Boston Children’s Hospital Learn More Learn More MICROBIOMESTOP THE GUESSWORK
Find out what’s really going on in your microbiome with a precision snapshot of microbial function, host interaction, and therapeutic response. Science Goes On JOIN THE CONVERSATION Microbiome. Vaccine development. COVID-19. Biomarker discovery. Join industry experts from across the globe to learn and share your insights on leading topics in life science and metabolomics. Get OurNewsletter
WORKING WITH METABOLON Metabolon deciphers thousands of discrete chemical signals from genetic and non-genetic factors to DISCOVER BIOMARKERS and reveal biological pathways. We make connections where other ‘omics cannot, and provide the DEFINITIVE REPRESENTATION OF THE PHENOTYPE. Talk With an Expert About Your Study__ Personalized guidance at every step From study design to sample collection, report visualization to biological interpretation, Metabolon experts guide you every step ofthe way.
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Chart the best course With expertise honed over more than 10,000 projects, our early study design guidance can help ensure your study is properly powered, properly controlled and aligned to your research objectives.__
Build a strong foundation The quality of your sample is everything. Our Sample Prep team provides time-tested sample collection and handling guidelines for collection and storage, volume requirements and tube selection to ensure you are prepped for success, right from the start.__
Harness the power of historical insight at industrial scale Our integrated bioinformatics solution makes it possible to efficiently and accurately mine the world’s largest Tier 1 metabolomics compound library for every study, to ensure consistently reliable results, every time.__
Precisely powerful platform Metabolon’s global Precision Metabolomics™ LC-MS platform can help detect more unique metabolites than any other platform.__
Rise above the noise Voluminous metabolomics data sets are often riddled with noisy ion features. Our highly trained curation staff has the skills and technical expertise to confidently navigate large data sets to deliver a reliable, high-fidelity view of your results.__
We take you beyond the data Our Discovery and Translational Science experts elevate meaningful biological insights from pages of spreadsheet data to help narrate a comprehensive and credible story of your research discoveries.About Metabolomics
SMALL MOLECULES, BIG INSIGHTS Metabolomics can provide a UNIQUE, REAL-TIME FINGERPRINT of your biological system to reveal novel discoveries and realize the promise of precision medicine.Learn More__
A TRUSTED PARTNER FOR 20 YEARS 1,300+ clients. 10,000 projects. Learn why researchers around the world have put their trust in Metabolon for two decades. See All Client Stories__ “At Siolta, we are utilizing both untargeted and targeted metabolomic approaches to help characterize the overall metabolic signatures associated with treatment and response and potentially provide insight into patient stratification for more precise therapeutic approaches moving forward.”VIEW CLIENT STORY
Nikole Kimes, Ph.D.
Co-Founder & CEO
Siolta
“Living in a microscopic world, cells communicate with each other by speaking in small molecules. We’re seeing a conversation happen between the microbiome and body, and metabolomics allows us to listen to the language spoken by the microbiome to the body.”VIEW CLIENT STORY
Sean M. Gibbons, Ph.D.Assistant Professor
Institute for Systems Biology, Washington Research Foundation Distinguished Investigator “Metabolites are the physical interface between circadian clocks and metabolism – they communicate between tissues.”VIEW CLIENT STORY
Paolo Sassone-Corsi, Ph.D. Donald Bren Professor and Director of the Center for Epigenetics andMetabolism
University of California, Irvine*
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ENLIGHTEN YOUR RESEARCH, ACCELERATE YOUR DISCOVERY.Demo Our Data
or Talk With an Expert__ LATEST INSIGHTS & NEWSVisit our blog__
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20 May 2021
EVALUATING METABOLITE STABILITY OF BLOOD SAMPLES FOR CLINICALAPPLICATIONS
Metabolon’s extensive work establishes criteria for evaluating metabolite stability in clinical metabolomic applications and provides guidelines for disqualifying unstable metabolites deriving from sample handling and processing in clinical metabolomic studies to ensure pre-analytical compliance.__
17 May 2021
THE HEALTHCARE TECHNOLOGY REPORT NAMES ROHAN F. HASTIE A TOP 50 HEALTHCARE TECHNOLOGY CEO OF 2021 Dr. Hastie has been at the helm of Metabolon since 2018, when initiated the company’s efforts to dramatically expand awareness and application of metabolomics in the biopharma market, setting a vision of enlightening life and enabling a healthier world.__
28 April 2021
METABOLOMICS AND SHOTGUN METAGENOMICS REVEAL EVIDENCE THAT GLYPHOSATE EXPOSURE AFFECTS THE GUT MICROBIOME A multi-omics approach provides valuable insights for investigating complex areas of science to enhance our understanding while Metabolon’s platform delivers interpretive depth not possible elsewhere. Additionally, the profiling of multiple matrices allowed for analysis of both microbiome derived compounds as well as how those changes may be reflected systemically, giving the work a much broaderimpact.
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