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human health.
JAX ® MICE AND SERVICESFIND & ORDER MICEMOUSE IDENTIFICATIONONCOLOGY JAX® Mice are the most published and well characterized mouse models in the world, and include the only fully sequenced strain, C57BL/6J. Take advantage of the convenience of having your husbandry, sourcing, and efficacy evaluation needs met by JAX.PRICELIST - JAX
This pricing list was generated on 6/4/2021 7:12:50 PM and is not guaranteed. All prices are subject to change without notice. See JAX Mice Pricing Information for moreHEALTH REPORTS
Overview. JAX ® Mice are bred within and shipped from multiple breeding rooms; health reports from all areas are available as PDF files (see below). These reports are organized on the basis of the breeding room of origin. To determine which room houses a strain of interest, see the "Technical Support" tab on the strain data sheet, or call Customer Service at 1-800-422-6423 (US, Canada 034860 - B6.CG-TG(K18-ACE2)2PRLMN/J - JAX The ~6.8 kb K18-hACE2 transgene was designed with, from 5' to 3', 2.5 kb of genomic sequence, including the promoter, and the first intron (with a mutation in the 3' splice acceptor site to reduce exon skipping) from the human keratin 18 (KRT18) gene, and a translational enhancer (TE) sequence from alfalfa mosaic virus.This was followed by the human angiotensin I converting enzyme (peptidyl 003724 - B6.FVB-TG(EIIA-CRE)C5379LMGD/J - JAX Detailed Description. This line carries a cre transgene under the control of the adenovirus EIIa promoter that targets expression of Cre recombinase to the early mouse embryo. Cre expression is thought to occur prior to implantation in the uterine wall. A mosaic pattern of expression is commonly observed. Cre-mediated recombination occurs ina
010905 - B6.CG-TG(SRY)2EI SRY/ARNOJ - JAX XY - mice with the dl1Rlb allele in the sex determining region of the Y chromosome ( Sry ) gene, are phenotypic gonadal females. XX Tg(Sry)2Ei mice carrying the Tg(Sry)2Ei transgene are phenotypic gonadal males. The combination of these two mutations produces four "core" genotypes that may be useful in the study of the interaction of sex chromosomes and gonadal type that influences phenotypic 012237 - B6.CG-TG(CDH16-CRE)91IGR/J - JAX These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 ( Cdh16 or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may be useful in kidney-specific gene targeting and cell lineage studies. WHEN ARE MICE CONSIDERED OLD? Mice ranging from 18 - 24 months of age correlate with humans ranging from 56 - 69 years of age. This age range meets the definition of “old,” which is the presence of senescent changes in almost all biomarkers in all animals. For C57BL/6J mice, the upper limit for this group is ~24 months, when the onset of strain-specific diseases can MGI-MOUSE GENOME INFORMATICS-THE INTERNATIONAL DATABASE MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease. About Us MGI Publications Cite Us. 1. THE JACKSON LABORATORYFIND & ORDER MICEJAX MICE & SERVICESCONTACTRESEARCH & FACULTYEDUCATION & LEARNING The Jackson Laboratory is an independent, nonprofit organization focusing on mammalian genetics research to advance human health. Our mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improvehuman health.
JAX ® MICE AND SERVICESFIND & ORDER MICEMOUSE IDENTIFICATIONONCOLOGY JAX® Mice are the most published and well characterized mouse models in the world, and include the only fully sequenced strain, C57BL/6J. Take advantage of the convenience of having your husbandry, sourcing, and efficacy evaluation needs met by JAX.PRICELIST - JAX
This pricing list was generated on 6/4/2021 7:12:50 PM and is not guaranteed. All prices are subject to change without notice. See JAX Mice Pricing Information for moreHEALTH REPORTS
Overview. JAX ® Mice are bred within and shipped from multiple breeding rooms; health reports from all areas are available as PDF files (see below). These reports are organized on the basis of the breeding room of origin. To determine which room houses a strain of interest, see the "Technical Support" tab on the strain data sheet, or call Customer Service at 1-800-422-6423 (US, Canada 034860 - B6.CG-TG(K18-ACE2)2PRLMN/J - JAX The ~6.8 kb K18-hACE2 transgene was designed with, from 5' to 3', 2.5 kb of genomic sequence, including the promoter, and the first intron (with a mutation in the 3' splice acceptor site to reduce exon skipping) from the human keratin 18 (KRT18) gene, and a translational enhancer (TE) sequence from alfalfa mosaic virus.This was followed by the human angiotensin I converting enzyme (peptidyl 003724 - B6.FVB-TG(EIIA-CRE)C5379LMGD/J - JAX Detailed Description. This line carries a cre transgene under the control of the adenovirus EIIa promoter that targets expression of Cre recombinase to the early mouse embryo. Cre expression is thought to occur prior to implantation in the uterine wall. A mosaic pattern of expression is commonly observed. Cre-mediated recombination occurs ina
010905 - B6.CG-TG(SRY)2EI SRY/ARNOJ - JAX XY - mice with the dl1Rlb allele in the sex determining region of the Y chromosome ( Sry ) gene, are phenotypic gonadal females. XX Tg(Sry)2Ei mice carrying the Tg(Sry)2Ei transgene are phenotypic gonadal males. The combination of these two mutations produces four "core" genotypes that may be useful in the study of the interaction of sex chromosomes and gonadal type that influences phenotypic 012237 - B6.CG-TG(CDH16-CRE)91IGR/J - JAX These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 ( Cdh16 or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may be useful in kidney-specific gene targeting and cell lineage studies. WHEN ARE MICE CONSIDERED OLD? Mice ranging from 18 - 24 months of age correlate with humans ranging from 56 - 69 years of age. This age range meets the definition of “old,” which is the presence of senescent changes in almost all biomarkers in all animals. For C57BL/6J mice, the upper limit for this group is ~24 months, when the onset of strain-specific diseases can MGI-MOUSE GENOME INFORMATICS-THE INTERNATIONAL DATABASE MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease. About Us MGI Publications Cite Us. 1. HACE2 TRANSGENIC MOUSE MODEL FOR CORONAVIRUS (COVID-19 Mouse models play a critical role in both vaccine and drug development. Studies have shown that SARS-CoV enters the human body by binding to human angiotensin-converting enzyme 2 (ACE2). However, due to structural differences in mouse ACE2 compared to human ACE2 proteins, the SARS coronaviruses exhibit poor tropism characteristics for mouse tissues and are inefficient at infecting mice.WEBINARS - JAX
Attend live webinars. JAX Webinars bring together industry experts and qualified genetics researchers to deliver live presentations on mouse models for research and development. NSG ™ VARIANTS PORTFOLIO NSG™ mice (005557) are the most highly immunodeficient mice and the model of choice for cancer xenograft modeling, stem cell biology, humanized mice, and infectious disease research. 010905 - B6.CG-TG(SRY)2EI SRY/ARNOJ - JAX XY - mice with the dl1Rlb allele in the sex determining region of the Y chromosome ( Sry ) gene, are phenotypic gonadal females. XX Tg(Sry)2Ei mice carrying the Tg(Sry)2Ei transgene are phenotypic gonadal males. The combination of these two mutations produces four "core" genotypes that may be useful in the study of the interaction of sex chromosomes and gonadal type that influences phenotypic CRE LOX BREEDING FOR BEGINNERS, PART 1 The Cre/ lox system is one of the most powerful and versatile tools developed for mouse genetics. It gives mouse researchers sophisticated control over the location and timing of gene expression. Cre/ lox is usually used to make knockout alleles, but it can also be used to activate gene expression. The proper insertion of a loxP -flanked 008169 - B6;C3-TG(PRNP-MAPT*P301S)PS19VLE/J - JAX Development. The P301S transgene was designed with the P301S mutant human microtubule-associated protein tau (MAPT*P301S) under the direction of the mouse prion protein promoter ( Prnp ). This transgene was injected into fertilized B6C3F1 mouse eggs. Transgenic founder animals were bred to B6C3F1/J or B6C3F1/Crl mice to establish founderline
012237 - B6.CG-TG(CDH16-CRE)91IGR/J - JAX These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 ( Cdh16 or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may be useful in kidney-specific gene targeting and cell lineage studies. 003724 - B6.FVB-TG(EIIA-CRE)C5379LMGD/J - JAX Detailed Description. This line carries a cre transgene under the control of the adenovirus EIIa promoter that targets expression of Cre recombinase to the early mouse embryo. Cre expression is thought to occur prior to implantation in the uterine wall. A mosaic pattern of expression is commonly observed. Cre-mediated recombination occurs ina
JAX CKB
The Clinical Knowledgebase (CKB) Powered by The Jackson Laboratory. CKB is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of protein impact, therapies, and clinical trials. CKB CORE is the public access version we have been providing to the community since 2016. 002374 - FVB/N-TG(MMTV-PYVT)634MUL/J Hemizygous MMTV-PyMT females develop palpable mammary tumors which metastasize to the lung. These mice have high penetrance of early onset of mammary cancer compared to other mammary tumor models. Male carriers also develop mammary tumors with a later age of onset. MMTV-PyVT transgenic mice express the Polyoma Virus middle T antigen under the direction of the mouse mammary tumor THE JACKSON LABORATORYFIND & ORDER MICEJAX MICE & SERVICESCONTACTRESEARCH & FACULTYEDUCATION & LEARNING The Jackson Laboratory is an independent, nonprofit organization focusing on mammalian genetics research to advance human health. Our mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improvehuman health.
JAX ® MICE AND SERVICESFIND & ORDER MICEMOUSE IDENTIFICATIONONCOLOGY JAX® Mice are the most published and well characterized mouse models in the world, and include the only fully sequenced strain, C57BL/6J. Take advantage of the convenience of having your husbandry, sourcing, and efficacy evaluation needs met by JAX.PRICELIST - JAX
This pricing list was generated on 6/4/2021 7:12:50 PM and is not guaranteed. All prices are subject to change without notice. See JAX Mice Pricing Information for moreHEALTH REPORTS
Overview. JAX ® Mice are bred within and shipped from multiple breeding rooms; health reports from all areas are available as PDF files (see below). These reports are organized on the basis of the breeding room of origin. To determine which room houses a strain of interest, see the "Technical Support" tab on the strain data sheet, or call Customer Service at 1-800-422-6423 (US, Canada 034860 - B6.CG-TG(K18-ACE2)2PRLMN/J - JAXJAX LABORATORYTHE JACKSON LABORATORY CHINATHE JACKSON LABORATORY CTTHE JACKSON LABORATORY GLASSDOORTHE JACKSON LABORATORY JOBSTHE JACKSON LABORATORY MAINE The ~6.8 kb K18-hACE2 transgene was designed with, from 5' to 3', 2.5 kb of genomic sequence, including the promoter, and the first intron (with a mutation in the 3' splice acceptor site to reduce exon skipping) from the human keratin 18 (KRT18) gene, and a translational enhancer (TE) sequence from alfalfa mosaic virus.This was followed by the human angiotensin I converting enzyme (peptidyl 008169 - B6;C3-TG(PRNP-MAPT*P301S)PS19VLE/J - JAX The P301S transgene was designed with the P301S mutant human microtubule-associated protein tau (MAPT*P301S) under the direction of the mouse prion protein promoter (Prnp).This transgene was injected into fertilized B6C3F1 mouse eggs. 010905 - B6.CG-TG(SRY)2EI SRY/ARNOJ - JAX XY - mice with the dl1Rlb allele in the sex determining region of the Y chromosome ( Sry ) gene, are phenotypic gonadal females. XX Tg(Sry)2Ei mice carrying the Tg(Sry)2Ei transgene are phenotypic gonadal males. The combination of these two mutations produces four "core" genotypes that may be useful in the study of the interaction of sex chromosomes and gonadal type that influences phenotypic 012237 - B6.CG-TG(CDH16-CRE)91IGR/J - JAX These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 ( Cdh16 or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may be useful in kidney-specific gene targeting and cell lineage studies. MGI-MOUSE GENOME INFORMATICS-THE INTERNATIONAL DATABASE MGI Workshops. If you would like to host an MGI workshop at your institution, contact User Support to discuss the details. A typical MGI workshop includes a brief presentation and a hands-on, interactive tutorial ().If you would like to schedule a remote interactive session to learn to use MGI, contact User Support to discuss the details. WHEN ARE MICE CONSIDERED OLD? Mice are widely used models for both aging and senescence because of their similarity to humans. These two terms, though often used interchangeably, are not the same. THE JACKSON LABORATORYFIND & ORDER MICEJAX MICE & SERVICESCONTACTRESEARCH & FACULTYEDUCATION & LEARNING The Jackson Laboratory is an independent, nonprofit organization focusing on mammalian genetics research to advance human health. Our mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improvehuman health.
JAX ® MICE AND SERVICESFIND & ORDER MICEMOUSE IDENTIFICATIONONCOLOGY JAX® Mice are the most published and well characterized mouse models in the world, and include the only fully sequenced strain, C57BL/6J. Take advantage of the convenience of having your husbandry, sourcing, and efficacy evaluation needs met by JAX.PRICELIST - JAX
This pricing list was generated on 6/4/2021 7:12:50 PM and is not guaranteed. All prices are subject to change without notice. See JAX Mice Pricing Information for moreHEALTH REPORTS
Overview. JAX ® Mice are bred within and shipped from multiple breeding rooms; health reports from all areas are available as PDF files (see below). These reports are organized on the basis of the breeding room of origin. To determine which room houses a strain of interest, see the "Technical Support" tab on the strain data sheet, or call Customer Service at 1-800-422-6423 (US, Canada 034860 - B6.CG-TG(K18-ACE2)2PRLMN/J - JAXJAX LABORATORYTHE JACKSON LABORATORY CHINATHE JACKSON LABORATORY CTTHE JACKSON LABORATORY GLASSDOORTHE JACKSON LABORATORY JOBSTHE JACKSON LABORATORY MAINE The ~6.8 kb K18-hACE2 transgene was designed with, from 5' to 3', 2.5 kb of genomic sequence, including the promoter, and the first intron (with a mutation in the 3' splice acceptor site to reduce exon skipping) from the human keratin 18 (KRT18) gene, and a translational enhancer (TE) sequence from alfalfa mosaic virus.This was followed by the human angiotensin I converting enzyme (peptidyl 008169 - B6;C3-TG(PRNP-MAPT*P301S)PS19VLE/J - JAX Development. The P301S transgene was designed with the P301S mutant human microtubule-associated protein tau (MAPT*P301S) under the direction of the mouse prion protein promoter ( Prnp ). This transgene was injected into fertilized B6C3F1 mouse eggs. Transgenic founder animals were bred to B6C3F1/J or B6C3F1/Crl mice to establish founderline
010905 - B6.CG-TG(SRY)2EI SRY/ARNOJ - JAX XY - mice with the dl1Rlb allele in the sex determining region of the Y chromosome ( Sry ) gene, are phenotypic gonadal females. XX Tg(Sry)2Ei mice carrying the Tg(Sry)2Ei transgene are phenotypic gonadal males. The combination of these two mutations produces four "core" genotypes that may be useful in the study of the interaction of sex chromosomes and gonadal type that influences phenotypic 012237 - B6.CG-TG(CDH16-CRE)91IGR/J - JAX These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 ( Cdh16 or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may be useful in kidney-specific gene targeting and cell lineage studies. WHEN ARE MICE CONSIDERED OLD? Mice ranging from 18 - 24 months of age correlate with humans ranging from 56 - 69 years of age. This age range meets the definition of “old,” which is the presence of senescent changes in almost all biomarkers in all animals. For C57BL/6J mice, the upper limit for this group is ~24 months, when the onset of strain-specific diseases can MGI-MOUSE GENOME INFORMATICS-THE INTERNATIONAL DATABASE MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease. About Us MGI Publications Cite Us. 1.WEBINARS - JAX
Attend live webinars. JAX Webinars bring together industry experts and qualified genetics researchers to deliver live presentations on mouse models for research and development. HACE2 TRANSGENIC MOUSE MODEL FOR CORONAVIRUS (COVID-19 Mouse models play a critical role in both vaccine and drug development. Studies have shown that SARS-CoV enters the human body by binding to human angiotensin-converting enzyme 2 (ACE2). However, due to structural differences in mouse ACE2 compared to human ACE2 proteins, the SARS coronaviruses exhibit poor tropism characteristics for mouse tissues and are inefficient at infecting mice.MCGI UPDATE
MCGI 2.0 Update. The MCGI team continues to work towards the rollout for MCGI 2.0 which includes the second observational study protocol. Meetings for MCGI 2.0 with practice research staff will begin in early April as we initiate new patient accrual. NSG ™ VARIANTS PORTFOLIO NSG™ mice (005557) are the most highly immunodeficient mice and the model of choice for cancer xenograft modeling, stem cell biology, humanized mice, and infectious disease research. CRE LOX BREEDING FOR BEGINNERS, PART 1 The Cre/ lox system is one of the most powerful and versatile tools developed for mouse genetics. It gives mouse researchers sophisticated control over the location and timing of gene expression. Cre/ lox is usually used to make knockout alleles, but it can also be used to activate gene expression. The proper insertion of a loxP -flankedJAX CKB
The Clinical Knowledgebase (CKB) Powered by The Jackson Laboratory. CKB is a dynamic digital resource for interpreting complex cancer genomic profiles in the context of protein impact, therapies, and clinical trials. CKB CORE is the public access version we have been providing to the community since 2016. 012237 - B6.CG-TG(CDH16-CRE)91IGR/J - JAX These Ksp1.3/Cre transgenic mice express Cre recombinase under the control of the mouse cadherin 16 ( Cdh16 or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in the renal tubules of adult mice. This mutant mouse strain may be useful in kidney-specific gene targeting and cell lineage studies. 010905 - B6.CG-TG(SRY)2EI SRY/ARNOJ - JAX XY - mice with the dl1Rlb allele in the sex determining region of the Y chromosome ( Sry ) gene, are phenotypic gonadal females. XX Tg(Sry)2Ei mice carrying the Tg(Sry)2Ei transgene are phenotypic gonadal males. The combination of these two mutations produces four "core" genotypes that may be useful in the study of the interaction of sex chromosomes and gonadal type that influences phenotypic 002374 - FVB/N-TG(MMTV-PYVT)634MUL/J Hemizygous MMTV-PyMT females develop palpable mammary tumors which metastasize to the lung. These mice have high penetrance of early onset of mammary cancer compared to other mammary tumor models. Male carriers also develop mammary tumors with a later age of onset. MMTV-PyVT transgenic mice express the Polyoma Virus middle T antigen under the direction of the mouse mammary tumorMICE-T.JAX.ORG
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