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STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageMELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageMELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden ConservancyMELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research. STORIES - MELANOMA RESEARCH ALLIANCE The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support.PATIENT RESOURCES
The Melanoma Exchange provides a critical platform for all those touched by melanoma to find support and ask questions related to melanoma, melanoma treatment and relevant research, including clinical trials. Group members share personal experiences and insight, the latest treatment news, dispel rumors about clinical trials, and morein this
STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
UNDERSTANDING MELANOMA STAGING Understanding Melanoma Staging. Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system that uses three key pieces of information for assigning Tumor-Node-Metastasis (TNM) classifications. In 2016, the AJCC expanded its staging guidelines to incorporate additional evidence-based prognosticfactors.
STAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
PATIENT STORIES
Tara Miller's Story. To say that Tara Miller inspired mixed emotions is to begin to understand her life. The strong-willed survivor, who lost her battle to melanoma in 2014, reflected the contradictions that define an indomitable will to live. Miller was both unconventional and devout, fearless in conviction and vulnerable in realism, facing BELMONT STAKES DRINK RECIPES The Belmont Jewel. 1.5 oz bourbon. 2 oz lemonade. 1 oz pomegranate juice. Orange zest. Shake vigorously with ice and serve in a rocks glass with ice. Garnish with a lemon twist. MRA AT THE RACES FUNDRAISER IDEAS In our example, Hot Rod Charlie finished first, Rombauer second, and Midnight Bourbon third. So Dan wins the $163.50 split of the Win pot, Jeff wins the $122.50 of the Place pot, and Kathyrn wins the $108.50of the Show pot.
HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageMELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageMELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden ConservancyMELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research. STORIES - MELANOMA RESEARCH ALLIANCE The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support.PATIENT RESOURCES
The Melanoma Exchange provides a critical platform for all those touched by melanoma to find support and ask questions related to melanoma, melanoma treatment and relevant research, including clinical trials. Group members share personal experiences and insight, the latest treatment news, dispel rumors about clinical trials, and morein this
STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
UNDERSTANDING MELANOMA STAGING Understanding Melanoma Staging. Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system that uses three key pieces of information for assigning Tumor-Node-Metastasis (TNM) classifications. In 2016, the AJCC expanded its staging guidelines to incorporate additional evidence-based prognosticfactors.
STAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
PATIENT STORIES
Tara Miller's Story. To say that Tara Miller inspired mixed emotions is to begin to understand her life. The strong-willed survivor, who lost her battle to melanoma in 2014, reflected the contradictions that define an indomitable will to live. Miller was both unconventional and devout, fearless in conviction and vulnerable in realism, facing BELMONT STAKES DRINK RECIPES The Belmont Jewel. 1.5 oz bourbon. 2 oz lemonade. 1 oz pomegranate juice. Orange zest. Shake vigorously with ice and serve in a rocks glass with ice. Garnish with a lemon twist. MRA AT THE RACES FUNDRAISER IDEAS In our example, Hot Rod Charlie finished first, Rombauer second, and Midnight Bourbon third. So Dan wins the $163.50 split of the Win pot, Jeff wins the $122.50 of the Place pot, and Kathyrn wins the $108.50of the Show pot.
HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes Stage PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes Stage PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden ConservancyMELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.PATIENT RESOURCES
The Melanoma Exchange provides a critical platform for all those touched by melanoma to find support and ask questions related to melanoma, melanoma treatment and relevant research, including clinical trials. Group members share personal experiences and insight, the latest treatment news, dispel rumors about clinical trials, and morein this
UNDERSTANDING MELANOMA STAGING Understanding Melanoma Staging. Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system that uses three key pieces of information for assigning Tumor-Node-Metastasis (TNM) classifications. In 2016, the AJCC expanded its staging guidelines to incorporate additional evidence-based prognosticfactors.
NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
2021 SCIENTIFIC RETREAT ADVANCING MELANOMA RESEARCH IN 01 Letter from Chief Science Officer and Senior Director, Scientific Program 03 The Melanoma Research Community Meets the Moment 05 Melanoma Screening Challenges and Controversies 09 The Next Frontier of Combination Immunotherapy: Maximizing the Benefits & Reducing Harms 13 Averting and Treating Immune-related Adverse Events Associated with Checkpoint ImmunotherapiesSTAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials.STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
MONTHLY SELF EXAM
Step 1: Looking at the mirror, examine your face, ears, neck, chest, and stomach. Women should remember to examine under their breasts. Use a comb to help examine your scalp. Step 2: Carefully examine your fingers and hands, palms, arms, underarms. Be sure to look carefully at the fronts, backs, and sides of each arm!PATIENT STORIES
Tara Miller's Story. To say that Tara Miller inspired mixed emotions is to begin to understand her life. The strong-willed survivor, who lost her battle to melanoma in 2014, reflected the contradictions that define an indomitable will to live. Miller was both unconventional and devout, fearless in conviction and vulnerable in realism, facing DONATE TO MRA UNSPECIFIED/GENERAL The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection. HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes Stage PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes Stage PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.PATIENT RESOURCES
The Melanoma Exchange provides a critical platform for all those touched by melanoma to find support and ask questions related to melanoma, melanoma treatment and relevant research, including clinical trials. Group members share personal experiences and insight, the latest treatment news, dispel rumors about clinical trials, and morein this
UNDERSTANDING MELANOMA STAGING Understanding Melanoma Staging. Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system that uses three key pieces of information for assigning Tumor-Node-Metastasis (TNM) classifications. In 2016, the AJCC expanded its staging guidelines to incorporate additional evidence-based prognosticfactors.
2021 SCIENTIFIC RETREAT ADVANCING MELANOMA RESEARCH IN 01 Letter from Chief Science Officer and Senior Director, Scientific Program 03 The Melanoma Research Community Meets the Moment 05 Melanoma Screening Challenges and Controversies 09 The Next Frontier of Combination Immunotherapy: Maximizing the Benefits & Reducing Harms 13 Averting and Treating Immune-related Adverse Events Associated with Checkpoint Immunotherapies NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
STAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials.STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
MONTHLY SELF EXAM
Step 1: Looking at the mirror, examine your face, ears, neck, chest, and stomach. Women should remember to examine under their breasts. Use a comb to help examine your scalp. Step 2: Carefully examine your fingers and hands, palms, arms, underarms. Be sure to look carefully at the fronts, backs, and sides of each arm!PATIENT STORIES
Tara Miller's Story. To say that Tara Miller inspired mixed emotions is to begin to understand her life. The strong-willed survivor, who lost her battle to melanoma in 2014, reflected the contradictions that define an indomitable will to live. Miller was both unconventional and devout, fearless in conviction and vulnerable in realism, facing DONATE TO MRA UNSPECIFIED/GENERAL The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection. HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes Stage PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes Stage PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden ConservancyMELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.PATIENT RESOURCES
The Melanoma Exchange provides a critical platform for all those touched by melanoma to find support and ask questions related to melanoma, melanoma treatment and relevant research, including clinical trials. Group members share personal experiences and insight, the latest treatment news, dispel rumors about clinical trials, and morein this
UNDERSTANDING MELANOMA STAGING Understanding Melanoma Staging. Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system that uses three key pieces of information for assigning Tumor-Node-Metastasis (TNM) classifications. In 2016, the AJCC expanded its staging guidelines to incorporate additional evidence-based prognosticfactors.
2021 SCIENTIFIC RETREAT ADVANCING MELANOMA RESEARCH IN 01 Letter from Chief Science Officer and Senior Director, Scientific Program 03 The Melanoma Research Community Meets the Moment 05 Melanoma Screening Challenges and Controversies 09 The Next Frontier of Combination Immunotherapy: Maximizing the Benefits & Reducing Harms 13 Averting and Treating Immune-related Adverse Events Associated with Checkpoint Immunotherapies NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
STAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials.STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
MONTHLY SELF EXAM
Step 1: Looking at the mirror, examine your face, ears, neck, chest, and stomach. Women should remember to examine under their breasts. Use a comb to help examine your scalp. Step 2: Carefully examine your fingers and hands, palms, arms, underarms. Be sure to look carefully at the fronts, backs, and sides of each arm!PATIENT STORIES
Tara Miller's Story. To say that Tara Miller inspired mixed emotions is to begin to understand her life. The strong-willed survivor, who lost her battle to melanoma in 2014, reflected the contradictions that define an indomitable will to live. Miller was both unconventional and devout, fearless in conviction and vulnerable in realism, facing DONATE TO MRA UNSPECIFIED/GENERAL The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection. HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageSTAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageSTAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. UNDERSTANDING MELANOMA STAGING Understanding Melanoma Staging. Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system that uses three key pieces of information for assigning Tumor-Node-Metastasis (TNM) classifications. In 2016, the AJCC expanded its staging guidelines to incorporate additional evidence-based prognosticfactors.
NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
STAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials. 2021 SCIENTIFIC RETREAT ADVANCING MELANOMA RESEARCH IN 01 Letter from Chief Science Officer and Senior Director, Scientific Program 03 The Melanoma Research Community Meets the Moment 05 Melanoma Screening Challenges and Controversies 09 The Next Frontier of Combination Immunotherapy: Maximizing the Benefits & Reducing Harms 13 Averting and Treating Immune-related Adverse Events Associated with Checkpoint Immunotherapies MELANOMA SURVIVAL RATES Just Diagnosed? If you've been recently diagnosed with melanoma, you are not alone. The Melanoma > Exchange is a free online melanoma treatment and research focused discussion group and support community. Through the Melanoma > Exchange, anyone touched by Melanoma can find support, ask questions, and build community among people who share asimilar experience.
IPILIMUMAB (YERVOY®) Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma.ACRAL MELANOMA
Acral melanoma, sometimes called acral lentiginous melanoma, is a rare type of skin melanoma that forms on the palms, soles of feet, or under finger or toe nails. Acral melanoma is the most common type of melanoma among people with darker skin. NIVOLUMAB (OPDIVO®) + IPILIMUMAB (YERVOY®) Nivolumab removes the PD-1 "shield" to allow your immune system to find and attack melanoma cells. Ipilimumab essentially turns on the immune response, allowing T cells to begin the attack on melanoma. Nivolumab then removes the immune protection that cancer cells put up to defend themselves from attacks. Nivolumab and ipilimumab aresystemic
DONATE TO MRA UNSPECIFIED/GENERAL The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection. HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageSTAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageSTAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. UNDERSTANDING MELANOMA STAGING Understanding Melanoma Staging. Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system that uses three key pieces of information for assigning Tumor-Node-Metastasis (TNM) classifications. In 2016, the AJCC expanded its staging guidelines to incorporate additional evidence-based prognosticfactors.
NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
STAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials. 2021 SCIENTIFIC RETREAT ADVANCING MELANOMA RESEARCH IN 01 Letter from Chief Science Officer and Senior Director, Scientific Program 03 The Melanoma Research Community Meets the Moment 05 Melanoma Screening Challenges and Controversies 09 The Next Frontier of Combination Immunotherapy: Maximizing the Benefits & Reducing Harms 13 Averting and Treating Immune-related Adverse Events Associated with Checkpoint Immunotherapies MELANOMA SURVIVAL RATES Just Diagnosed? If you've been recently diagnosed with melanoma, you are not alone. The Melanoma > Exchange is a free online melanoma treatment and research focused discussion group and support community. Through the Melanoma > Exchange, anyone touched by Melanoma can find support, ask questions, and build community among people who share asimilar experience.
IPILIMUMAB (YERVOY®) Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma.ACRAL MELANOMA
Acral melanoma, sometimes called acral lentiginous melanoma, is a rare type of skin melanoma that forms on the palms, soles of feet, or under finger or toe nails. Acral melanoma is the most common type of melanoma among people with darker skin. NIVOLUMAB (OPDIVO®) + IPILIMUMAB (YERVOY®) Nivolumab removes the PD-1 "shield" to allow your immune system to find and attack melanoma cells. Ipilimumab essentially turns on the immune response, allowing T cells to begin the attack on melanoma. Nivolumab then removes the immune protection that cancer cells put up to defend themselves from attacks. Nivolumab and ipilimumab aresystemic
DONATE TO MRA UNSPECIFIED/GENERAL The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection. HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageSTAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageSTAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy UNDERSTANDING MELANOMA STAGING Understanding Melanoma Staging. Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system that uses three key pieces of information for assigning Tumor-Node-Metastasis (TNM) classifications. In 2016, the AJCC expanded its staging guidelines to incorporate additional evidence-based prognosticfactors.
NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
STAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials. 2021 SCIENTIFIC RETREAT ADVANCING MELANOMA RESEARCH IN 01 Letter from Chief Science Officer and Senior Director, Scientific Program 03 The Melanoma Research Community Meets the Moment 05 Melanoma Screening Challenges and Controversies 09 The Next Frontier of Combination Immunotherapy: Maximizing the Benefits & Reducing Harms 13 Averting and Treating Immune-related Adverse Events Associated with Checkpoint Immunotherapies MELANOMA SURVIVAL RATES Just Diagnosed? If you've been recently diagnosed with melanoma, you are not alone. The Melanoma > Exchange is a free online melanoma treatment and research focused discussion group and support community. Through the Melanoma > Exchange, anyone touched by Melanoma can find support, ask questions, and build community among people who share asimilar experience.
NIVOLUMAB (OPDIVO®) + IPILIMUMAB (YERVOY®) Nivolumab removes the PD-1 "shield" to allow your immune system to find and attack melanoma cells. Ipilimumab essentially turns on the immune response, allowing T cells to begin the attack on melanoma. Nivolumab then removes the immune protection that cancer cells put up to defend themselves from attacks. Nivolumab and ipilimumab aresystemic
IPILIMUMAB (YERVOY®) Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma.ACRAL MELANOMA
Acral melanoma, sometimes called acral lentiginous melanoma, is a rare type of skin melanoma that forms on the palms, soles of feet, or under finger or toe nails. Acral melanoma is the most common type of melanoma among people with darker skin. DONATE TO MRA UNSPECIFIED/GENERAL The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection. DONATE TO MRA TRIBUTE GIFT The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection.*
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SUMMER KRAMER: ALIGNING PASSION WITH PURPOSE Frustrated with her inability to find stylish UPF protective clothing after her own melanoma diagnosis, Summer Kramer founded her own company called SUMMERSKIN. Now, eight years later, she has aligned her passion with purpose through a new partnership with the MelanomaResearch Alliance.
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AGAINST THE ODDS: RACING FOR MELANOMA RESEARCH Patrick O’Neill along with his four closest college friends and fellow Boat Racing, LLC members, find themselves in a very implausible position: first-time horse owners heading to the Kentucky Derby—horseracing’s pinnacle event. See how Patrick and his friends are using this experience to raise awareness of melanoma and to help raise money for MRA's research program.Read More __
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UV EXPOSURE & RISK OF CUTANEOUS MELANOMA IN SKIN OF COLOR In JAMA Dermatology, a team led by Adewole S. Adamson, MD, from The University of Texas at Austin, investigates whether there is an association, specifically in People of Color, between UV exposure and melanoma. MRA breaks down the research findings and evaluates how it should impact your sun safety practices.Read More __
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RELENTLESS IN THE FIGHT: DR. F. STEPHEN HODI Every revolution needs trailblazers—people who restlessly and relentlessly search for paths forward. At MRA, we’re fortunate to partner with innovative trailblazers who are guiding the entire field of melanoma further, such as two time MRA-funded investigator Dr. F.Stephen Hodi.
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A MELANOMA MIRACLE PAID FORWARD When Lauren was living in Tanzania, she made a bucket list that included 'seeing a miracle." Little did she know she would become her own melanoma miracle. Almost eight years later, she is just beginning her career as a nurse and continues to be NED.Read More __
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05/20/2021 – SPOTMYUV: Your Sunscreen’s New Best Friend 04/27/2021 – Melanoma Research Alliance Announces $8.1 million inResearch Awards
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