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2 MINUTE MEDICINE
2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. RANDOMIZED TRIAL OF PLANT-DERIVED VACCINE FOR COVID-19 1. A plant-derived, virus-like particle displays the SARS-CoV-2 spike glycoprotein and appears to be a promising candidate for a vaccine. 2. Adverse outcomes were mild-to-moderate, transient, and dependent on adjuvant. Evidence Rating Level: 1 (Excellent) Study Rundown: Available vaccines for COVID-19 are proving to be effective and safe. However, the demand for vaccines across REINFECTION RATES AMONG PATIENTS PREVIOUSLY TESTING 1. Among a large U.S. cohort, previous infection with SARS-CoV-2 appears to confer high levels of immunity against reinfection for at least 8 months. Evidence Level Rating: 2 (Good) As of early March 2021, SARS-CoV-2 has infected nearly 120 million individuals worldwide. The subsequent duration of immunity to reinfection is unknown; infection with common seasonal FORTIFICATION OF BREAST MILK WITH PRETERM FORMULA POWDER 1. Fortification of expressed breast milk with preterm formula was found to be non-inferior to human milk fortifier with regards to short-term weight gain among preterm neonates. Evidence Level Rating: 1 (Excellent) Because expressed breast milk (EBM) is not sufficient to meet the high nutrient requirements of preterm neonates, many countries, especially low- and low-middle RECURRENCE OF ENDOMETRIAL HYPERPLASIA FOLLOWING MEDICAL 1. Many women developed recurrence, most within the first 6 months after cessation of therapy. 2. There were no differences in relapse rate between the 3 treatment arms. Evidence Rating Level: 1 (Excellent) Study Rundown: Endometrial cancer is the most common gynecologic malignancy affecting women in the U.S. The primary risk factor is exposure to excess, FLUTICASONE-SALMETEROL COMBINATION THERAPY SAFE AND 1. For patients with moderate-to-severe asthma, fluticasone-salmeterol combination therapy was not associated with a higher risk of serious asthma-related events than fluticasone alone. 2. Fluticasone-salmeterol combination therapy, especially during adolescence, is associated with a significantly lower risk of severe asthma exacerbations.2 MINUTE MEDICINE
2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. RANDOMIZED TRIAL OF PLANT-DERIVED VACCINE FOR COVID-19 1. A plant-derived, virus-like particle displays the SARS-CoV-2 spike glycoprotein and appears to be a promising candidate for a vaccine. 2. Adverse outcomes were mild-to-moderate, transient, and dependent on adjuvant. Evidence Rating Level: 1 (Excellent) Study Rundown: Available vaccines for COVID-19 are proving to be effective and safe. However, the demand for vaccines across REINFECTION RATES AMONG PATIENTS PREVIOUSLY TESTING 1. Among a large U.S. cohort, previous infection with SARS-CoV-2 appears to confer high levels of immunity against reinfection for at least 8 months. Evidence Level Rating: 2 (Good) As of early March 2021, SARS-CoV-2 has infected nearly 120 million individuals worldwide. The subsequent duration of immunity to reinfection is unknown; infection with common seasonal FORTIFICATION OF BREAST MILK WITH PRETERM FORMULA POWDER 1. Fortification of expressed breast milk with preterm formula was found to be non-inferior to human milk fortifier with regards to short-term weight gain among preterm neonates. Evidence Level Rating: 1 (Excellent) Because expressed breast milk (EBM) is not sufficient to meet the high nutrient requirements of preterm neonates, many countries, especially low- and low-middle RECURRENCE OF ENDOMETRIAL HYPERPLASIA FOLLOWING MEDICAL 1. Many women developed recurrence, most within the first 6 months after cessation of therapy. 2. There were no differences in relapse rate between the 3 treatment arms. Evidence Rating Level: 1 (Excellent) Study Rundown: Endometrial cancer is the most common gynecologic malignancy affecting women in the U.S. The primary risk factor is exposure to excess, FLUTICASONE-SALMETEROL COMBINATION THERAPY SAFE AND 1. For patients with moderate-to-severe asthma, fluticasone-salmeterol combination therapy was not associated with a higher risk of serious asthma-related events than fluticasone alone. 2. Fluticasone-salmeterol combination therapy, especially during adolescence, is associated with a significantly lower risk of severe asthma exacerbations. WELLNESS CHECK: MENTAL HEALTH 1 day ago · 2 Minute Medicine is pleased to announce that we are launching Wellness Check, a new series dedicated to exploring new research evidence focused on wellness. Each week, we will report on articles examining different aspects of wellness, including (but not limited to) nutrition, sleep, reproductive health, substance use and mental health. This week, we explore COGNITIVE BEHAVIORAL THERAPY MAY IMPROVE OUTCOMES IN 14 hours ago · 1. In this randomized control trial, individualized cognitive behavioral therapy (CBT) for prolonged grief disorder was superior to supportive therapy in reducing symptoms at both 6- and 12-month follow-up. 2. Participants in the CBT Grief-Help group also demonstrated decreased symptoms of depression, post-traumatic stress disorder (PTSD), and lower levels of internalizing problems REPORTS OF MYOCARDITIS IN HEALTHY ADOLESCENTS AFTER PFIZER 1. In a case series, 7 healthy male adolescents aged 14-19 developed acute myocarditis or myopericarditis within 4 days of receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine. 2. All patients recovered rapidly after treatment with non-steroidal anti-inflammatory (NSAID) medications, intravenous immune globulin, and/orcorticosteroids.
STUDY OUTLINES TRENDS IN PEDIATRIC TOXIC INGESTIONS DURING 1. In this national study of poison control center reports, there was an absolute decrease in reported pediatric ingestions during the first year of the pandemic compared to previous years. 2. Ingestions managed at hospitals decreased, while ingestions that resulted in moderate to severe clinical outcomes increased. Evidence Rating Level: 2 (Good)Study Rundown: The
CARRIERS OF GENETIC VARIANTS OF INHERITED CARDIOMYOPATHIES 1. In this study of White and African American adults who had unexplained sudden cardiac death, nearly 20% of individuals had pathogenic or likely pathogenic variants consistent with inherited cardiomyopathies or arrhythmia syndromes, despite having normal cardiac findings. 2. These findings suggest that genetic testing could play a greater role in the prevention of unexplained CONVALESCENT PLASMA DOES NOT IMPROVE SURVIVAL IN PATIENTS 1. A similar proportion of patients died within 28 days of randomization in both groups (high-titre convalescent plasma vs. usual care). 2. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days. Evidence Rating Level: 1 (Excellent) Study Rundown: Convalescent plasma is a form of passive TYMPANOSTOMY TUBES NOT SUPERIOR TO MEDICAL MANAGEMENT FOR 1. Tympanostomy tubes were not shown to be superior to medical management for recurrent acute otitis media. 2. There was no substantial difference for elevated antimicrobial resistance in medical management compared to tympanostomy tube treatment. Evidence Rating Level: 1 (Excellent) Study Rundown: Acute otitis media is the second most commonly diagnosed childhood illness in NET FLUID BALANCE NOT ASSOCIATED WITH HOSPITAL READMISSION 1. There was no association found between positive fluid balance at the time of discharge and readmission at 30 days post-discharge in non-critically ill patients hospitalized for sepsis. Evidence Rating Level: 2 (Good) Study Rundown: Evidence suggests that the administration of intravenous fluids in patients hospitalized for sepsis is associated with lower mortality. IMPLANTABLE LOOP RECORDER ASSOCIATED WITH INCREASED 1. In patients with recent ischemic stroke and no diagnosed atrial fibrillation (AF), there were increased AF diagnoses in those who received an implantable loop recorder compared with those who received an external loop recorder within 12 months of the intervention. Evidence Rating Level: 1 (Excellent) Study Rundown: Atrial fibrillation (AF) is one of the PROLONGED EXPOSURE THERAPY MORE EFFECTIVE FOR SEXUAL ABUSE Image: PD 1. Compared to supportive counseling, prolonged exposure therapy for sexual abuse-related PTSD was more effective at reducing symptoms in adolescent girls. 2. Improvement in symptoms remained significant up to 12 months after treatment completion. Evidence Rating Level: 1 (Excellent) Study Rundown: This randomized clinical trial found that prolonged exposure therapy2 MINUTE MEDICINE
2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. 2 MINUTE MEDICINE REWIND MAY 31, 2021 A population-based analysis of the impact of the COVID-19 pandemic on common abdominal and gynecological emergency department visits 1. Emergency department visits for common medical emergencies dropped at the start of the COVID-19 pandemic, but with no changes in complication or mortality rates from these emergencies. Evidence Rating Level: 2 (Good) Due to the COMBINED CAGRILINTIDE AND SEMAGLUTIDE FOR WEIGHT 1. Semaglutide 2.4 mg combined with once weekly cagrilintide therapy was not associated with increase in adverse events compared to semaglutide alone. 2. Compared to control, combined cagrilintide and semaglutide improved glycemic parameters and mean body weight reduction at 20 weeks. Evidence Rating Level: 1 (Excellent) Study Rundown: Semaglutide is a glucagon-like peptide-1 FORTIFICATION OF BREAST MILK WITH PRETERM FORMULA POWDER 1. Fortification of expressed breast milk with preterm formula was found to be non-inferior to human milk fortifier with regards to short-term weight gain among preterm neonates. Evidence Level Rating: 1 (Excellent) Because expressed breast milk (EBM) is not sufficient to meet the high nutrient requirements of preterm neonates, many countries, especially low- and low-middle REINFECTION RATES AMONG PATIENTS PREVIOUSLY TESTING Initial infection status was based on PCR testing performed prior to 30 August 2020. 150,325 patients had tests performed prior to this date, with 8,845 testing positive. After at least 90 days, 1,278 of these previously positive patients were retested, with 62 reviewed for reinfection. 31 of these reinfected patients were symptomatic, and 18 PRETERM FORMULA POWDER IS NOT INFERIOR TO HUMAN MILK 1. When used to fortify human breast milk for preterm neonates, no significant weight gain differences were seen from using either Preterm Formula Powder or Breast Milk Fortifier. 2. A higher prevalence of feed intolerance was reported when breast milk was fortified with human milk fortifier compared to preterm formula powder. Evidence Rating Level: 1 FLUTICASONE-SALMETEROL COMBINATION THERAPY SAFE AND 1. For patients with moderate-to-severe asthma, fluticasone-salmeterol combination therapy was not associated with a higher risk of serious asthma-related events than fluticasone alone. 2. Fluticasone-salmeterol combination therapy, especially during adolescence, is associated with a significantly lower risk of severe asthma exacerbations. THE CLOT TRIAL: DALTEPARIN VERSUS WARFARIN [CLASSICS This study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Medicine: Summaries of the Landmark Trials, 1e (The Classics Series). 1. Dalteparin, a low-molecular-weight heparin, is superior to warfarin in preventing recurrent venous thromboembolism in the setting of malignancy. 2. There is no significant difference in risk of major bleeding with RECURRENCE OF ENDOMETRIAL HYPERPLASIA FOLLOWING MEDICAL Recurrence of endometrial hyperplasia following medical therapy is common. 1. Many women developed recurrence, most within the first 6 months after cessation of therapy. 2. There were no differences in relapse rate between the 3 treatment arms. Study Rundown: Endometrial cancer is the most common gynecologic malignancy affecting women inthe U.S.
CARDIAC RISK FACTORS ASSOCIATED WITH NONCALCIFIED PLAQUE 1. In asymptomatic patients with low-to-moderate risk for coronary artery disease, computed tomography coronary angiography revealed increased total coronary plaque index in men than in women. 2. Total non-calcified, soft coronary plaque burden in asymptomatic patients was associated with risk factors for cardiovascular disease including low-density lipoprotein cholesterol levels,2 MINUTE MEDICINE
2 Minute Medicine® is an award winning, physician-run, expert medical media company originally founded out of Harvard Medical School and the Massachusetts Institute of Technology. 2 MINUTE MEDICINE REWIND MAY 31, 2021 A population-based analysis of the impact of the COVID-19 pandemic on common abdominal and gynecological emergency department visits 1. Emergency department visits for common medical emergencies dropped at the start of the COVID-19 pandemic, but with no changes in complication or mortality rates from these emergencies. Evidence Rating Level: 2 (Good) Due to the COMBINED CAGRILINTIDE AND SEMAGLUTIDE FOR WEIGHT 1. Semaglutide 2.4 mg combined with once weekly cagrilintide therapy was not associated with increase in adverse events compared to semaglutide alone. 2. Compared to control, combined cagrilintide and semaglutide improved glycemic parameters and mean body weight reduction at 20 weeks. Evidence Rating Level: 1 (Excellent) Study Rundown: Semaglutide is a glucagon-like peptide-1 REINFECTION RATES AMONG PATIENTS PREVIOUSLY TESTING Initial infection status was based on PCR testing performed prior to 30 August 2020. 150,325 patients had tests performed prior to this date, with 8,845 testing positive. After at least 90 days, 1,278 of these previously positive patients were retested, with 62 reviewed for reinfection. 31 of these reinfected patients were symptomatic, and 18 FORTIFICATION OF BREAST MILK WITH PRETERM FORMULA POWDER 1. Fortification of expressed breast milk with preterm formula was found to be non-inferior to human milk fortifier with regards to short-term weight gain among preterm neonates. Evidence Level Rating: 1 (Excellent) Because expressed breast milk (EBM) is not sufficient to meet the high nutrient requirements of preterm neonates, many countries, especially low- and low-middle SEPSIS PERFORMANCE MEASURE IMPLEMENTATION NOT ASSOCIATED 1. Adoption of the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) program resulted in greater adherence to individual process measures such as lactate measurement, early antibiotics, and fluid therapy. 2. These increases were variable in magnitude and did not associate with meaningful changes in sepsis outcomes. Evidence Rating Level: 2 (Good) Study Rundown: THE CLOT TRIAL: DALTEPARIN VERSUS WARFARIN [CLASSICS This study summary is an excerpt from the book 2 Minute Medicine’s The Classics in Medicine: Summaries of the Landmark Trials, 1e (The Classics Series). 1. Dalteparin, a low-molecular-weight heparin, is superior to warfarin in preventing recurrent venous thromboembolism in the setting of malignancy. 2. There is no significant difference in risk of major bleeding with RECURRENCE OF ENDOMETRIAL HYPERPLASIA FOLLOWING MEDICAL Recurrence of endometrial hyperplasia following medical therapy is common. 1. Many women developed recurrence, most within the first 6 months after cessation of therapy. 2. There were no differences in relapse rate between the 3 treatment arms. Study Rundown: Endometrial cancer is the most common gynecologic malignancy affecting women inthe U.S.
LONG-TERM GLUCOSAMINE SULFATE LIKELY IMPROVES PAIN AND 1. In this systematic review and meta-analysis of patients with knee osteoarthritis (OA) receiving a variety of pharmacologic treatments, glucosamine sulfate was associated with improvement in long-term pain. 2. Glucosamine sulfate was also associated with better physical functioning and joint space narrowing. Evidence Rating Level: 1 (Excellent) Study Rundown: There are many treatments for CARDIAC RISK FACTORS ASSOCIATED WITH NONCALCIFIED PLAQUE 1. In asymptomatic patients with low-to-moderate risk for coronary artery disease, computed tomography coronary angiography revealed increased total coronary plaque index in men than in women. 2. Total non-calcified, soft coronary plaque burden in asymptomatic patients was associated with risk factors for cardiovascular disease including low-density lipoprotein cholesterol levels, RANDOMIZED TRIAL OF PLANT-DERIVED VACCINE FOR COVID-19 1. A plant-derived, virus-like particle displays the SARS-CoV-2 spike glycoprotein and appears to be a promising candidate for a vaccine. 2. Adverse outcomes were mild-to-moderate, transient, and dependent on adjuvant. Evidence Rating Level: 1 (Excellent) Study Rundown: Available vaccines for COVID-19 are proving to be effective and safe. However, the demand for vaccines across the VOCLOSPORIN SHOWS CLINICAL PROMISE FOR TREATMENT OF ACTIVE 8 hours ago · 1. A significantly greater proportion of patients in the voclosporin group achieved complete renal responses after 52 weeks compared to the placebo group. 2. The safety profile between the voclosporin group and placebo group were comparable with 21% of patients in both groups experiencing serious adverse events. Evidence Rating Level: 1 (Excellent) Study Rundown: Nearly REPORTS OF MYOCARDITIS IN HEALTHY ADOLESCENTS AFTER PFIZER 8 hours ago · 1. In a case series, 7 healthy male adolescents aged 14-19 developed acute myocarditis or myopericarditis within 4 days of receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine. 2. All patients recovered rapidly after treatment with non-steroidal anti-inflammatory (NSAID) medications, intravenous immune globulin, and/or corticosteroids. TYMPANOSTOMY TUBES NOT SUPERIOR TO MEDICAL MANAGEMENT FOR 1. Tympanostomy tubes were not shown to be superior to medical management for recurrent acute otitis media. 2. There was no substantial difference for elevated antimicrobial resistance in medical management compared to tympanostomy tube treatment. Evidence Rating Level: 1 (Excellent) Study Rundown: Acute otitis media is the second most commonly diagnosed childhood illness in IMPLANTABLE LOOP RECORDER ASSOCIATED WITH INCREASED 1. In patients with recent ischemic stroke and no diagnosed atrial fibrillation (AF), there were increased AF diagnoses in those who received an implantable loop recorder compared with those who received an external loop recorder within 12 months of the intervention. Evidence Rating Level: 1 (Excellent) Study Rundown: Atrial fibrillation (AF) is one of the RAPID RESPIRATORY PATHOGEN TESTING DOES NOT SIGNIFICANTLY 10 hours ago · 1. When treating children with an acute respiratory illness in the emergency department, no significant difference in antibiotic prescription rates was observed when clinicians knew rapid respiratory pathogen test results, compared to when clinicians did not. 2. Children with an acute respiratory illness whose clinician knew rapid respiratory pathogen test results had longer emergency CHEMORADIOTHERAPY ASSOCIATED WITH EFFECTIVENESS COMPARABLE 1. Primary treatment with chemoradiotherapy when treating oropharyngeal squamous cell carcinoma had improved progression-free survival and distant metastasis-free survival compared to when treated with upfront surgery. 2. There was no significant difference in mortality during the study period in the upfront surgical treatment versus chemoradiotherapy groups. POLICY STATEMENT OUTLINES 1. The American Academy of Pediatrics (AAP) recommends that newborns born to mothers affected by or being tested for COVID-19 be temporarily separated from their mothers. It is also recommended that these infants be separated from newborns born to unaffected mothers in order to reduce risk of transmission. 2. The report also recommendsthat for
EFFECT OF COGNITIVE BEHAVIORAL THERAPY-BASED COUNSELING ON 19 hours ago · 1. Cognitive behavioral therapy (CBT)-based counseling significantly improved perceived stress, anxiety, and quality of life among women with primary infertility. 2. Measures of depression suggested minimal effects of CBT-based counseling on these symptoms, based on this sample. Evidence Rating Level: 1 (Excellent) It is estimated that infertility impacts 11 to 51 million peopleworldwide.
CARRIERS OF GENETIC VARIANTS OF INHERITED CARDIOMYOPATHIES 1. In this study of White and African American adults who had unexplained sudden cardiac death, nearly 20% of individuals had pathogenic or likely pathogenic variants consistent with inherited cardiomyopathies or arrhythmia syndromes, despite having normal cardiac findings. 2. These findings suggest that genetic testing could play a greater role in the prevention of unexplained__
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LONG‐TERM CARDIOVASCULAR OUTCOMES AFTER PREGNANCY IN WOMEN WITHHEART DISEASE
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