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STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageSTAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support.STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
NIVOLUMAB (OPDIVO®) + IPILIMUMAB (YERVOY®) Nivolumab removes the PD-1 "shield" to allow your immune system to find and attack melanoma cells. Ipilimumab essentially turns on the immune response, allowing T cells to begin the attack on melanoma. Nivolumab then removes the immune protection that cancer cells put up to defend themselves from attacks. Nivolumab and ipilimumab aresystemic
DABRAFENIB (TAFINLAR®) + TRAMETINIB (MEKINIST®) Patients take both medications orally (swallowing by mouth). The recommended dose for dabrafenib is 150 mg twice each day, via 50 or 75 mg capsules. The recommended dose for trametinib is 2 mg once each day, via 0.5, 1, or 2 mg tablets. Depending on how you respond to treatment, your physician may adjust your doses. HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes StageSTAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support.STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
NIVOLUMAB (OPDIVO®) + IPILIMUMAB (YERVOY®) Nivolumab removes the PD-1 "shield" to allow your immune system to find and attack melanoma cells. Ipilimumab essentially turns on the immune response, allowing T cells to begin the attack on melanoma. Nivolumab then removes the immune protection that cancer cells put up to defend themselves from attacks. Nivolumab and ipilimumab aresystemic
DABRAFENIB (TAFINLAR®) + TRAMETINIB (MEKINIST®) Patients take both medications orally (swallowing by mouth). The recommended dose for dabrafenib is 150 mg twice each day, via 50 or 75 mg capsules. The recommended dose for trametinib is 2 mg once each day, via 0.5, 1, or 2 mg tablets. Depending on how you respond to treatment, your physician may adjust your doses.MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
STAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials. MELANOMA SURVIVAL RATES Just Diagnosed? If you've been recently diagnosed with melanoma, you are not alone. The Melanoma > Exchange is a free online melanoma treatment and research focused discussion group and support community. Through the Melanoma > Exchange, anyone touched by Melanoma can find support, ask questions, and build community among people who share asimilar experience.
ENCORAFENIB (BRAFTOVI™) + BINIMETINIB (MEKTOVI Encorafenib (Braftovi) and binimetinib (Mektovi) are a combination therapy that blocks the activity of different molecules within cancer cells that cause the cancer to grow and spread. This combination of targeted therapies treats advanced melanoma more effectively than the single drugs while producing less serious side effects.T-VEC (IMLYGIC™)
T-VEC is an oncolytic virus therapy, a treatment that uses a virus to infect and kill cancer cells while avoiding normal, healthy cells. T-VEC is made from a genetically modified herpes virus, commonly known as the cold sore virus. The therapy is designed to replicate inside melanoma cells to kill those cells. DONATE TO MRA UNSPECIFIED/GENERAL The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection. 2020-2021 REQUEST FOR PROPOSALS About the MRA: MRA is a public charity formed in 2007 under the auspices of the Milken Institute, with the generous founding support of Debra and Leon Black. The mission of MRA is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas.DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy DONATE TO MRA TRIBUTE GIFT The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection. HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes Stage PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes Stage PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden ConservancyMELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.PATIENT RESOURCES
The Melanoma Exchange provides a critical platform for all those touched by melanoma to find support and ask questions related to melanoma, melanoma treatment and relevant research, including clinical trials. Group members share personal experiences and insight, the latest treatment news, dispel rumors about clinical trials, and morein this
UNDERSTANDING MELANOMA STAGING Understanding Melanoma Staging. Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system that uses three key pieces of information for assigning Tumor-Node-Metastasis (TNM) classifications. In 2016, the AJCC expanded its staging guidelines to incorporate additional evidence-based prognosticfactors.
NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
2021 SCIENTIFIC RETREAT ADVANCING MELANOMA RESEARCH IN 01 Letter from Chief Science Officer and Senior Director, Scientific Program 03 The Melanoma Research Community Meets the Moment 05 Melanoma Screening Challenges and Controversies 09 The Next Frontier of Combination Immunotherapy: Maximizing the Benefits & Reducing Harms 13 Averting and Treating Immune-related Adverse Events Associated with Checkpoint ImmunotherapiesSTAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials.STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
MONTHLY SELF EXAM
Step 1: Looking at the mirror, examine your face, ears, neck, chest, and stomach. Women should remember to examine under their breasts. Use a comb to help examine your scalp. Step 2: Carefully examine your fingers and hands, palms, arms, underarms. Be sure to look carefully at the fronts, backs, and sides of each arm!PATIENT STORIES
Tara Miller's Story. To say that Tara Miller inspired mixed emotions is to begin to understand her life. The strong-willed survivor, who lost her battle to melanoma in 2014, reflected the contradictions that define an indomitable will to live. Miller was both unconventional and devout, fearless in conviction and vulnerable in realism, facing DONATE TO MRA UNSPECIFIED/GENERAL The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection. HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes Stage PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden Conservancy HOME - MELANOMA RESEARCH ALLIANCEABOUT MELANOMAFOR PATIENTSRESEARCHGET INVOLVEDABOUT MRAJUST DIAGNOSED Melanoma Research Alliance is a leading funder of melanoma research, committed to accelerating scientific discovery and the development of new treatments and diagnostics for this deadly skin cancer. 100% of donations to the Melanoma Research Alliance go to research funding.STAGE 0 MELANOMA
Prognosis: Stage 0 melanoma, or melanoma in situ, is highly curable. There is very little risk for recurrence or metastasis. The 5-year survival rate as of 2018 for local melanoma, including Stage 0, is 98.4%. Click here to learn more about melanoma survival rates. Follow-Up Care: After being treated for Stage 0 melanoma, you shouldconduct
MELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.STAGE 1 MELANOMA
Stage 1 Melanoma. Stage I melanoma is no more than 1.0 millimeter thick (about the size of a sharpened pencil point), with or without an ulceration (broken skin). There is no evidence that Stage I melanoma has spread to the lymph tissues, lymph nodes, or body organs. Stage I melanoma is considered local melanoma (this group also includes Stage PATIENT & SURVIVOR STORIES Patient & Survivor Stories. The stories of patients and survivors are important reminders of why MRA is committed to ending death and suffering due to melanoma. These stories highlight the human impact of the research we support. BRESLOW DEPTH AND CLARK LEVEL The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis.STAGE 2 MELANOMA
Stage 2 Melanoma. Stage II melanoma extends beyond the epidermis (very outer layer of skin) into the thicker dermis layer of the skin. It is thicker than Stage I melanoma and is slightly more likely to metastasize. There is still no evidence that Stage II melanoma has spread to the lymph tissues, lymph nodes, or body organs. NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
DONATE TO MRA UNSPECIFIED/GENERAL The mission of the Melanoma Research Alliance (MRA) is to end suffering and death due to melanoma by collaborating with all stakeholders to accelerate powerful research, advance cures for all patients, and prevent more melanomas. If you prefer to donate using PayPal, please click this button. Dedicate my donation in honor or inmemory of someone.
DAISY HELMAN
Daisy Helman* is a lifelong gardener and California native who currently resides in New York City. She founded Garden Collage in 2015 to “bring the garden into people’s lives,” and passionately supports a range of local and national nonprofits that underscore this mission — including Edible Schoolyard NYC, New York Botanical Garden, Brooklyn Botanic Garden, The Garden ConservancyMELANOMA VACCINES
Melanoma Research. The Melanoma Research Alliance is the largest, non-profit funder of melanoma research worldwide. Since 2007, we have directly funded over $123 million in innovative grants to improve prevention, detection, and treatment of melanoma. We have also leveraged an additional $210 million in outside funds for research.PATIENT RESOURCES
The Melanoma Exchange provides a critical platform for all those touched by melanoma to find support and ask questions related to melanoma, melanoma treatment and relevant research, including clinical trials. Group members share personal experiences and insight, the latest treatment news, dispel rumors about clinical trials, and morein this
UNDERSTANDING MELANOMA STAGING Understanding Melanoma Staging. Melanoma staging is based on the American Joint Committee on Cancer (AJCC) staging system that uses three key pieces of information for assigning Tumor-Node-Metastasis (TNM) classifications. In 2016, the AJCC expanded its staging guidelines to incorporate additional evidence-based prognosticfactors.
2021 SCIENTIFIC RETREAT ADVANCING MELANOMA RESEARCH IN 01 Letter from Chief Science Officer and Senior Director, Scientific Program 03 The Melanoma Research Community Meets the Moment 05 Melanoma Screening Challenges and Controversies 09 The Next Frontier of Combination Immunotherapy: Maximizing the Benefits & Reducing Harms 13 Averting and Treating Immune-related Adverse Events Associated with Checkpoint Immunotherapies NIVOLUMAB (OPDIVO®) ADJUVANT THERAPY Nivolumab (Opdivo®) Adjuvant Therapy. Even after successfully removing melanoma through surgery, patients may be at risk for melanoma coming back. Nivolumab (Opdivo) in the adjuvant setting reduces this risk by stimulating the body’s immune system to fight any remaining cancer cells. In December 2017, the U.S. Food and DrugAdministration
STAGE 3 MELANOMA
Stage 3 Melanoma. Stage III melanoma, also known as regional melanoma, has metastasized (spread) to nearby lymph nodes, lymph vessels, or skin. Lymph nodes are an important part of the lymphatic system, which is a vast network of tissues and organs that helps rid the body of waste, toxins, and other unwanted materials.STAGE 4 MELANOMA
Stage 4 Melanoma. Stage IV melanoma has metastasized (spread) to other places throughout the body, such as the brain, lungs, liver, or gastrointestinal (GI) tract. Melanoma may also have spread to distant points in the skin. Stage IV melanoma is considered distant metastaticmelanoma.
MONTHLY SELF EXAM
Step 1: Looking at the mirror, examine your face, ears, neck, chest, and stomach. Women should remember to examine under their breasts. Use a comb to help examine your scalp. Step 2: Carefully examine your fingers and hands, palms, arms, underarms. Be sure to look carefully at the fronts, backs, and sides of each arm!PATIENT STORIES
Tara Miller's Story. To say that Tara Miller inspired mixed emotions is to begin to understand her life. The strong-willed survivor, who lost her battle to melanoma in 2014, reflected the contradictions that define an indomitable will to live. Miller was both unconventional and devout, fearless in conviction and vulnerable in realism, facing DONATE TO MRA UNSPECIFIED/GENERAL The Melanoma Research Alliance is the largest non-profit funder of melanoma research in the world. MRA funded research has fueled a revolution in immuno check-point and targeted therapies, and has helped to further advance prevention and detection.*
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STAGE 4 MELANOMA, A VACCINE CLINICAL TRIAL, AND THE POWER OF FAMILY &FAITH
“Clinical trials allow you to take advantage of the latest research and experiences from doctors and patients who’re blazing the trails. Clinical trials are also a way for you to help the next person who is going to have to go through this. If you have the opportunity to be part of something that helps others, why wouldn’t you at least tryit?”
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2020 MELANOMA MORTALITY RATES DECREASING DESPITE ONGOING INCREASE ININCIDENCE
This year, more than 100,00 people are estimated to be diagnosed with invasive melanoma in the United States - continuing a 30-year trend of increasing incidence (new cases). In contrast, melanoma mortality rates continue to decline highlighting impact of transformational advances in melanoma treatment science.Read More __
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BROWN SKIN TOO: IF YOU HAVE SKIN, YOU CAN GET SKIN CANCER While pervasive, the myth that people of color don’t need to worry about skin cancer, is entirely untrue. And while the rates of skin cancer among people of color are lower than rates for people with lighter skin, low risk doesn’t mean no risk.Read More __
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FIGHTING FOR HER LIFE WITH A CLINICAL TRIAL Colleen Wittoesch was a regular volunteer at MD Anderson Cancer Center. She came to the hospital every week to help out and spend time with patients and families in the melanoma clinic for going on seven years. Little did she know that in 2016 she too would walk through the clinic doors as a patient. Read Colleen's Story __1 of 4
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WHAT'S NEW
01/08/2020 – 2020 Melanoma Mortality Rates Decreasing Despite Ongoing Increase in Incidence 12/19/2019 – Leading Melanoma Organizations Applaud Congress for Supporting $20 million for Defense-Funded Melanoma Research 11/13/2019 – Approaches to Neoadjuvant Treatment in Melanoma: A Public Workshop Organized by the FDA and MRA 11/08/2019 – Mutations and Melanoma 11/05/2019 – Melanoma Research Alliance Announces Almost $20 Million in New Funding to Support Melanoma Research ProgramLOGIN
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