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factor Xa
TSH RECEPTOR ANTIBODIES TSH Receptor Antibodies: Nomenclature, Functionality and Assay Comparison . Dr. George J. Kahaly . Faculty PresentationsREGISTRATION
I would like Thermo Fisher Scientific (and its affiliates) to contact me by email to receive information on events, products, services and promotions which Thermo Fisher believes may be of interest to me. RECENT ADVANCES IN ORAL ANTICOAGULATION THERAPY FOR For several decades the “gold standard” for preventing the outcome of embolic stroke in patients with AFib has been the oral anticoagulation agent warfarin. This agent has many well-known side effects and adherence challenges for patients, however, and therefore the recent approvals of several new oral anticoagulation agents hasrepresented
RECENT ADVANCES IN ORAL ANTICOAGULATION THERAPY FOR After several decades during which the only oral anticoagulant agent that physicians could prescribe for patients was warfarin, new classes of novel oral anticoagulant (NOAC) agents have been approved.This presentation will review these new NOACs, highlight their recent clinical trial conclusions, and discuss their use considerations in atrial fibrillation (AFib). UPDATE ON UREA CYCLE DISORDERS TREATMENT UPDATE ON UREA CYCLE DISORDERS TREATMENT George A. Diaz, MD, PhD Program for Inherited Metabolic Diseases . Department of Genetics andGenomic
ANTICOAGULATION IN THE POST-WARFARIN ERA: WHERE ARE WE TODAY? References Mega JL, Braunwald E, Wiviott SD, et al. the ATLAS ACS 2–TIMI 51 Investigators. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012;366:9-19. TAKING CONTROL OF YOUR DIABETES If so, enter your email address and password, and press the Submit button. After logging in, you will be returned to this form with your information already filled in. Scroll down to the bottom of the page and click Continue to Pre-Test. If you do not have a TAKING CONTROL OF YOUR DIABETES Steven Edelman, MD. Jeremy Pettus, MD. Thank you for Viewing the Webinar. Please select your profession to receive credit for your attendance. Physician Click here if you are a Physician. Pharmacist Click here if you are a Pharmacist. RECENT ADVANCES IN ORAL ANTICOAGULATION THERAPY FOR The Figure shows the baseline population demographics for ROCKET AF. It can be seen that the population was quite similar in most respects to the enrollees in RE-LY, with a good distribution across the spectrum of renal function (shown at the bottom of ANTICOAGULATION IN THE POST-WARFARIN ERA: WHERE ARE WE TODAY? Ximelagatran was never approved because of hepatotoxicity, but several other new agents – called new or novel oral anticoagulants (NOACs) – have shown that they are either as effective as warfarin or superior to warfarin. These include. • the first 2 approvedfactor Xa
TSH RECEPTOR ANTIBODIES TSH Receptor Antibodies: Nomenclature, Functionality and Assay Comparison . Dr. George J. Kahaly . Faculty PresentationsREGISTRATION
I would like Thermo Fisher Scientific (and its affiliates) to contact me by email to receive information on events, products, services and promotions which Thermo Fisher believes may be of interest to me. RECENT ADVANCES IN ORAL ANTICOAGULATION THERAPY FOR For several decades the “gold standard” for preventing the outcome of embolic stroke in patients with AFib has been the oral anticoagulation agent warfarin. This agent has many well-known side effects and adherence challenges for patients, however, and therefore the recent approvals of several new oral anticoagulation agents hasrepresented
RECENT ADVANCES IN ORAL ANTICOAGULATION THERAPY FOR After several decades during which the only oral anticoagulant agent that physicians could prescribe for patients was warfarin, new classes of novel oral anticoagulant (NOAC) agents have been approved.This presentation will review these new NOACs, highlight their recent clinical trial conclusions, and discuss their use considerations in atrial fibrillation (AFib). UPDATE ON UREA CYCLE DISORDERS TREATMENT UPDATE ON UREA CYCLE DISORDERS TREATMENT George A. Diaz, MD, PhD Program for Inherited Metabolic Diseases . Department of Genetics andGenomic
ANTICOAGULATION IN THE POST-WARFARIN ERA: WHERE ARE WE TODAY? References Mega JL, Braunwald E, Wiviott SD, et al. the ATLAS ACS 2–TIMI 51 Investigators. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012;366:9-19. TAKING CONTROL OF YOUR DIABETES If so, enter your email address and password, and press the Submit button. After logging in, you will be returned to this form with your information already filled in. Scroll down to the bottom of the page and click Continue to Pre-Test. If you do not have a TAKING CONTROL OF YOUR DIABETES Steven Edelman, MD. Jeremy Pettus, MD. Thank you for Viewing the Webinar. Please select your profession to receive credit for your attendance. Physician Click here if you are a Physician. Pharmacist Click here if you are a Pharmacist. ANTICOAGULATION IN THE POST-WARFARIN ERA: WHERE ARE WE TODAY? There have been several meta-analyses of the value of the NOACs versus warfarin. Figure 13 (right) illustrates an analysis published by Dentali. Looking at the NOACs together, we can see that there is a significant reduction in all-cause mortality and cardiovascular mortality, both about 11%; a significant reduction in stroke or systemic embolism, about 23%; and a significant reduction in ANTICOAGULATION IN THE POST-WARFARIN ERA: WHERE ARE WE TODAY? Other patients should be risk stratified, for example by using the CHA 2 DS 2 - VASc scoring scheme. If the score is ≥2, anticoagulation is necessary. If the score is 1, then there is some room for considering the relative risks of bleeding versus anticoagulation and the wishes of the patient. In any event, when considering anticoagulation RECENT ADVANCES IN ORAL ANTICOAGULATION THERAPY FOR DABIGATRAN. The first NOAC to be approved in the United States was the DTI, dabigatran (Pradaxa; Boehringer Ingelheim). As shown in the Figure, this agent is absorbed from the gut and is rapidly converted to an active form by serum esterases.It is also conjugated to an active form in the liver, and in both of these forms dabigatran is an effective anticoagulant. ANTICOAGULATION IN THE POST-WARFARIN ERA: WHERE ARE WE TODAY? Another challenge with warfarin is the necessity to carefully control the dose because of several patient variables, including individual genetic differences, comorbidities, and comedications that may interact with the drug. Food and alcohol also have interactions with warfarin.. Serum levels of warfarin should be maintained at an international normalized ratio (INR) between 2.0 and 3.0 METASTATIC CASTRATE RESISTANT PROSTATE CANCER MANAGEMENT Clin Cancer Res. 2001;7:1932-1936. Smaletz O, Scher HI, Small EJ, et al. Nomogram for overall survival of patients with progressive metastatic prostate cancer after castration. J Clin Oncol. 2002;20:3972-3982. Halabi S, Small EJ, Kantoff PW, et al. Prognostic model for predicting survival in men with hormone-refractory metastaticREGISTRATION
I would like Thermo Fisher Scientific (and its affiliates) to contact me by email to receive information on events, products, services and promotions which Thermo Fisher believes may be of interest to me. RECENT ADVANCES IN ORAL ANTICOAGULATION THERAPY FOR After several decades during which the only oral anticoagulant agent that physicians could prescribe for patients was warfarin, new classes of novel oral anticoagulant (NOAC) agents have been approved.This presentation will review these new NOACs, highlight their recent clinical trial conclusions, and discuss their use considerations in atrial fibrillation (AFib). ANTICOAGULATION IN THE POST-WARFARIN ERA: WHERE ARE WE TODAY? Pointers towards which NOAC to Choose. When it comes to choosing which therapy to use for prevention of stroke and thromboembolism, neither the traditional VKA or NOAC therapy has proven to be a very good way of doing it. The trials to date simply provide a certain gestalt that will help the physician; this gestalt is expressed in these examples. ANTICOAGULATION IN THE POST-WARFARIN ERA: WHERE ARE WE TODAY? For physicians there are ways of gauging whether a patient is likely to stay in good INR control. There is an acronym – SAMe-TT 2 R 2 (Figure 8) – that provides a number of factors that we can assess. In this acronym, “S” stands for sex (female); A for an ageDetails
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