U.S. PHARMACIST

U.S. Pharmacist is the leading clinically-focused monthly pharmacy publication providing the nation's pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice. ANALGESIA AND SEDATION STRATEGIES IN COVID-19 PATIENTS Analgesia and Sedation Strategies in COVID-19 Patients. US Pharm. 2021;47 (3):HS-11-HS-16. ABSTRACT: The novel severe acute respiratory syndrome coronavirus 2, first discovered in December 2019, has presented with many challenges, impacting individuals globally with many requiring ICU admission and the need for invasive mechanical

ventilation

MANAGEMENT OF RADIATION-INDUCED NAUSEA AND VOMITINGSEE MORE ON

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ORAL MUCOSITIS AND COMPOUNDED MOUTHWASHESSEE MORE ON USPHARMACIST.COM QTC PROLONGATION WITH ANTIDEPRESSANTS AND ANTIPSYCHOTICSSEE MORE ON

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TREATMENT OF INSOMNIA IN HOSPITALIZED PATIENTSSEE MORE ON

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COMMON CAUSES OF DRUG-INDUCED SEIZURES US Pharm. 2010;35(1):20-23. It has been established that the elderly, particularly those with some degree of neurologic disease, are especially susceptible to the actions of medications. 1 In light of the ubiquity of polypharmacy in seniors, this column has previously presented an overview of the causes of seizures in the elderly with reference to the risk of drug-induced events. 2 In this DRUG-INDUCED SEROTONIN SYNDROMESEE MORE ON USPHARMACIST.COM STATIN-ASSOCIATED MYOPATHYSEE MORE ON USPHARMACIST.COM POSTMENOPAUSAL VAGINAL BLEEDING US Pharm. 2008;33(9):28-32. Although relatively common, vaginal bleeding is considered abnormal when reported in a woman who has passed the onset of menopause. 1 In approximately 20% to 30% of cases of postmenopausal vaginal bleeding, the cause may be attributed to endometrial cancer or atypical endometrial hyperplasia. 2 Additional causes include estrogen or progesterone therapy (i.e

U.S. PHARMACIST

U.S. Pharmacist is the leading clinically-focused monthly pharmacy publication providing the nation's pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice. MANAGEMENT OF RADIATION-INDUCED NAUSEA AND VOMITINGSEE MORE ON

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ANTITHROMBOTIC THERAPY IN PATIENTS WITH VALVULAR HEART DISEASE Antithrombotic Therapy for Valve Replacement. After valve replacement (s), antithrombotic therapy with an antiplatelet and vitamin K antagonist (VKA) is recommended with the dosing, duration, and international normalized ratio (INR) goal varying among bioprosthetic and mechanical replacements and TAVR. Administering daily low-dose

aspirin (75

COMMON CAUSES OF DRUG-INDUCED SEIZURES US Pharm. 2010;35(1):20-23. It has been established that the elderly, particularly those with some degree of neurologic disease, are especially susceptible to the actions of medications. 1 In light of the ubiquity of polypharmacy in seniors, this column has previously presented an overview of the causes of seizures in the elderly with reference to the risk of drug-induced events. 2 In this QTC PROLONGATION WITH ANTIDEPRESSANTS AND ANTIPSYCHOTICSSEE MORE ON

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ORAL TREATMENT OPTIONS FOR CHRONIC OSTEOMYELITISSEE MORE ON

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PROSTATE AND KIDNEY PRECAUTIONS WITH NONPRESCRIPTION PRODUCTS Prostate and Kidney Precautions With Nonprescription Products. US Pharm. 2011;36 (6):12-15. When patients ask for assistance with selection of an appropriate nonprescription product, it is vital for the pharmacist to be aware of the various label precautions and warnings. Several groups of products present potential problems for

patients with a

SERTRALINE REDUCES ANXIETY, NOT DEPRESSION, IN FIRST 6 WEEKS London, UK—Pharmacists, who regularly fill prescriptions for Zoloft and its generic equivalents, might be surprised by new research suggesting the early effects may be different from what has been commonly assumed. A study in The Lancet Psychiatry found that taking sertraline leads to an early reduction in anxiety symptoms, commonly found in depression, several weeks before any INTERPRETATION OF URINALYSIS AND URINE CULTURE FOR UTISEE MORE ON

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POSTMENOPAUSAL VAGINAL BLEEDING US Pharm. 2008;33(9):28-32. Although relatively common, vaginal bleeding is considered abnormal when reported in a woman who has passed the onset of menopause. 1 In approximately 20% to 30% of cases of postmenopausal vaginal bleeding, the cause may be attributed to endometrial cancer or atypical endometrial hyperplasia. 2 Additional causes include estrogen or progesterone therapy (i.e THE ROLE OF ORAL ANTIBIOTICS IN BACTERIAL BLOODSTREAM The Role of Oral Antibiotics in Bacterial Bloodstream Infections. US Pharm. 2021;46 (4):17-20. ABSTRACT: IV antibiotics are generally thought to be the mainstay of treatment for bloodstream infections due to their high bioavailability and fast peak plasma levels. However, the ideal route of administration of any medication is one that

achieves

ANTITHROMBOTIC THERAPY IN PATIENTS WITH VALVULAR HEART DISEASE Antithrombotic Therapy for Valve Replacement. After valve replacement (s), antithrombotic therapy with an antiplatelet and vitamin K antagonist (VKA) is recommended with the dosing, duration, and international normalized ratio (INR) goal varying among bioprosthetic and mechanical replacements and TAVR. Administering daily low-dose

aspirin (75

ORAL MUCOSITIS AND COMPOUNDED MOUTHWASHES The use of saline or baking soda mouthwash to soothe the pain and remove food particles to avoid infection. 4. Drinking plenty of liquids—at least 3 liters per day—and eschewing alcohol. 5. Avoiding citrus fruits, tomatoes, acidic foods, alcohol, and hot TREATMENT OF DEPRESSION IN PATIENTS ON ANTICOAGULATION US Pharm. 2013;38(11):23-26.. ABSTRACT: When used as monotherapy, warfarin is associated with an increased risk of bleeding. When warfarin is used concomitantly with other drugs that may also increase the risk of bleeding or affect the concentration of warfarin, the bleeding risk may be further increased. DIABETIC FOOT ULCER ASSESSMENT AND TREATMENT: A PHARMACIST Diabetic Foot Ulcer Assessment and Treatment: A Pharmacist’s Guide. US Pharm. 2010;35 (6):38-44. The lifetime incidence of developing a foot ulcer may be as high as 25% for the 24 million Americans with diabetes. 1 Ulcers, defined as any breaks in the cutaneous barrier, are the most frequent type of diabetic foot wounds and usually extend BUPRENORPHINE TRANSDERMAL PATCH: AN OVERVIEW FOR USE IN ABSTRACT: The buprenorphine transdermal patch (Butrans) is approved for use in patients with pain severe enough to require daily, around-the-clock, long-term opioid use when other treatment options are not adequate. Buprenorphine works as a partial agonist at the mu-opioid receptor. There are five different buprenorphine patch

strengths.

DRUG-INDUCED NUTRIENT DEPLETIONS: WHAT PHARMACISTS NEED TO ABSTRACT: Drug-induced nutrient depletions are critical to evaluate when pharmacists review the safety and efficacy of patients’ medication therapies. While certain drug-induced nutrient depletions are well known by pharmacists, many are underdiscussed and subsequently underdiagnosed and undertreated. This article will provide an overview of DO IMMUNOCOMPROMISED PATIENTS HAVE ENOUGH RESPONSE TO Baltimore, MD—Concerns are being raised about how effectively immunocompromised patients can mount an immune response after the first of two doses of a SARS-CoV-2 messenger RNA (mRNA) vaccine. A research letter published in JAMA suggests that, in those patients, the immune response to vaccination might be blunted. To add to understanding of that phenomenon, Johns GABAPENTIN 100 MG/ML ORAL SUSPENSION Gabapentin 100 mg/mL Oral Suspension. US Pharm. 2013;38 (1):33-34. Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared. Accurately weigh or measure each ingredient. Incorporate the Ora-Plus into the gabapentin and mix into a smooth paste. Add sufficient Ora-Sweet in portions, with mixing to

final

POSTMENOPAUSAL VAGINAL BLEEDING US Pharm. 2008;33(9):28-32. Although relatively common, vaginal bleeding is considered abnormal when reported in a woman who has passed the onset of menopause. 1 In approximately 20% to 30% of cases of postmenopausal vaginal bleeding, the cause may be attributed to endometrial cancer or atypical endometrial hyperplasia. 2 Additional causes include estrogen or progesterone therapy (i.e

U.S. PHARMACIST

U.S. Pharmacist is the leading clinically-focused monthly pharmacy publication providing the nation's pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice. ANALGESIA AND SEDATION STRATEGIES IN COVID-19 PATIENTS Analgesia and Sedation Strategies in COVID-19 Patients. US Pharm. 2021;47 (3):HS-11-HS-16. ABSTRACT: The novel severe acute respiratory syndrome coronavirus 2, first discovered in December 2019, has presented with many challenges, impacting individuals globally with many requiring ICU admission and the need for invasive mechanical

ventilation

MANAGEMENT OF RADIATION-INDUCED NAUSEA AND VOMITINGSEE MORE ON

USPHARMACIST.COM

ORAL MUCOSITIS AND COMPOUNDED MOUTHWASHESSEE MORE ON USPHARMACIST.COM QTC PROLONGATION WITH ANTIDEPRESSANTS AND ANTIPSYCHOTICSSEE MORE ON

USPHARMACIST.COM

TREATMENT OF INSOMNIA IN HOSPITALIZED PATIENTSSEE MORE ON

USPHARMACIST.COM

COMMON CAUSES OF DRUG-INDUCED SEIZURES US Pharm. 2010;35(1):20-23. It has been established that the elderly, particularly those with some degree of neurologic disease, are especially susceptible to the actions of medications. 1 In light of the ubiquity of polypharmacy in seniors, this column has previously presented an overview of the causes of seizures in the elderly with reference to the risk of drug-induced events. 2 In this DRUG-INDUCED SEROTONIN SYNDROMESEE MORE ON USPHARMACIST.COM STATIN-ASSOCIATED MYOPATHYSEE MORE ON USPHARMACIST.COM POSTMENOPAUSAL VAGINAL BLEEDING US Pharm. 2008;33(9):28-32. Although relatively common, vaginal bleeding is considered abnormal when reported in a woman who has passed the onset of menopause. 1 In approximately 20% to 30% of cases of postmenopausal vaginal bleeding, the cause may be attributed to endometrial cancer or atypical endometrial hyperplasia. 2 Additional causes include estrogen or progesterone therapy (i.e

U.S. PHARMACIST

U.S. Pharmacist is the leading clinically-focused monthly pharmacy publication providing the nation's pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice. ANALGESIA AND SEDATION STRATEGIES IN COVID-19 PATIENTS Analgesia and Sedation Strategies in COVID-19 Patients. US Pharm. 2021;47 (3):HS-11-HS-16. ABSTRACT: The novel severe acute respiratory syndrome coronavirus 2, first discovered in December 2019, has presented with many challenges, impacting individuals globally with many requiring ICU admission and the need for invasive mechanical

ventilation

MANAGEMENT OF RADIATION-INDUCED NAUSEA AND VOMITINGSEE MORE ON

USPHARMACIST.COM

ORAL MUCOSITIS AND COMPOUNDED MOUTHWASHESSEE MORE ON USPHARMACIST.COM QTC PROLONGATION WITH ANTIDEPRESSANTS AND ANTIPSYCHOTICSSEE MORE ON

USPHARMACIST.COM

TREATMENT OF INSOMNIA IN HOSPITALIZED PATIENTSSEE MORE ON

USPHARMACIST.COM

COMMON CAUSES OF DRUG-INDUCED SEIZURES US Pharm. 2010;35(1):20-23. It has been established that the elderly, particularly those with some degree of neurologic disease, are especially susceptible to the actions of medications. 1 In light of the ubiquity of polypharmacy in seniors, this column has previously presented an overview of the causes of seizures in the elderly with reference to the risk of drug-induced events. 2 In this DRUG-INDUCED SEROTONIN SYNDROMESEE MORE ON USPHARMACIST.COM STATIN-ASSOCIATED MYOPATHYSEE MORE ON USPHARMACIST.COM POSTMENOPAUSAL VAGINAL BLEEDING US Pharm. 2008;33(9):28-32. Although relatively common, vaginal bleeding is considered abnormal when reported in a woman who has passed the onset of menopause. 1 In approximately 20% to 30% of cases of postmenopausal vaginal bleeding, the cause may be attributed to endometrial cancer or atypical endometrial hyperplasia. 2 Additional causes include estrogen or progesterone therapy (i.e SUBMITTING A MANUSCRIPT Submitting a Manuscript. U.S. Pharmacist is a peer-reviewed journal that educates pharmacists about drugs (Rx and OTC) and their clinical applications, the current status of drug therapy in specific disease states, the skills and techniques necessary to counsel patients to achieve optimal outcomes, the legal and ethical aspects of

contemporary

PHARMACISTS SHOULD EXPECT TO ADMINISTER COVID-19 VACCINE Bethesda, MD—Pharmacists have been busy all year providing COVID-19 vaccines, and no end is in sight.One reason is the strong expectation that booster shots will be available in the fall for those who were vaccinated earlier this year. ANALGESIA AND SEDATION STRATEGIES IN COVID-19 PATIENTS Analgesia and Sedation Strategies in COVID-19 Patients. US Pharm. 2021;47 (3):HS-11-HS-16. ABSTRACT: The novel severe acute respiratory syndrome coronavirus 2, first discovered in December 2019, has presented with many challenges, impacting individuals globally with many requiring ICU admission and the need for invasive mechanical

ventilation

U.S. PHARMACIST WEEKLY NEWS UPDATE Pharmacists won’t be putting down their syringes any time soon. Growing evidence suggests that, even before initial COVID-19 vaccine doses are provided to all age groups, booster shots will be available in the autumn for those who were immunized earlier in the year. MEDICATIONS IN WIDE USE FOR SEVERE COVID-19 CHANGED OVER During the height of the COVID-19 pandemic, new medications were constantly being touted as showing promise to ameliorate the symptoms—or even cure—the sometimes-deadly virus. TRIAL SEEKS TO BETTER UNDERSTAND SEVERE ALLERGIC REACTIONS Fear of side effects or adverse reactions is one of the most common concerns expressed by Americans who refuse to get COVID-19 vaccines. Among the worst of those are severe allergic reactions, which, albeit rare, have been reported with the mRNA and other vaccines. PANDEMIC HAD DRAMATIC EFFECT ON CARE FOR PROSTATE-CANCER San Francisco, CA—While pharmacists currently are in the middle of the battle against COVID-19, providing vaccines and testing, their role at some point will shift to dealing with the aftermath of the viral outbreak. While some of that will be related to so-called long COVID, caring for patients whose symptoms continued after a viral infection, other efforts will be focused on the FOOD–DRUG INTERACTIONS One of the most well known food–drug interactions is grapefruit juice and the HMG-CoA reductase inhibitors, more commonly known as statins. Grapefruit juice, in large quantities (32 oz. or more per day), can inhibit the cytochrome P450 3A4 (CYP3A4) enzyme and increase blood levels of drugs metabolized by this pathway, such as certain

statin

GLENMARK PHARMACEUTICALS LAUNCHES RUFINAMIDE TABLETS USP Mumbai, India, June 1, 2021 – Glenmark Pharmaceuticals Limited (Glenmark) has launched Rufinamide Tablets USP, 200 mg and 400 mg, a therapeutic equivalent of Banzel ®1 Tablets, 200 mg and 400 mg of Eisai, Inc. Glenmark was one of the first ANDA applicants to submit a substantially complete ANDA for Rufinamide Tablets USP, 200 mg and 400 mg, with a paragraph IV certification and received GABAPENTIN 100 MG/ML ORAL SUSPENSION Gabapentin 100 mg/mL Oral Suspension. US Pharm. 2013;38 (1):33-34. Method of Preparation: Calculate the quantity of each ingredient for the amount to be prepared. Accurately weigh or measure each ingredient. Incorporate the Ora-Plus into the gabapentin and mix into a smooth paste. Add sufficient Ora-Sweet in portions, with mixing to

final

U.S. PHARMACIST

U.S. Pharmacist is the leading clinically-focused monthly pharmacy publication providing the nation's pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice. U.S. PHARMACIST WEEKLY NEWS UPDATE By Staff. U.S. Pharmacist Weekly News. May 12, 2021. ISMP Offers Tips on Avoiding Errors in COVID-19 Vaccine Administration. Certain errors are more common than others when administering COVID-19 vaccines, whether they involve check-in or preparation of the syringes. Find out what the Institute for Safe Medication Practices (ISMP) recommends to AUTHORIZED GENERICS: WHAT PHARMACISTS SHOULD KNOW Authorized Generics are a category of generic drugs made by the manufacturer of the brand name drug. They are the same as the brand name drug but do not use the brand name on the label and may have a different color or marking. 1. An Authorized Generic is marketed under the brand name drug’s New Drug Application (NDA) and is therefore

not

DO IMMUNOCOMPROMISED PATIENTS HAVE ENOUGH RESPONSE TO Baltimore, MD—Concerns are being raised about how effectively immunocompromised patients can mount an immune response after the first of two doses of a SARS-CoV-2 messenger RNA (mRNA) vaccine. A research letter published in JAMA suggests that, in those patients, the immune response to vaccination might be blunted. To add to understanding of that phenomenon, Johns MULTIPLE MYELOMA: AN OVERVIEW OF THE DISEASE AND TREATMENTSEE MORE ON

USPHARMACIST.COM

PHARMACIST CONSIDERATIONS FOR TREATING PATIENTS WITH ALS Hydrotherapy, heat, cold, electrical stimulation, chemodenervation, and surgery have been utilized to treat muscle spasticity. Physical therapy is the primary treatment for spasticity with positive evidence in ALS. 2 Pharmacotherapy with baclofen and tizanidine are typically

recommended.

UPDATED CLINICAL PRACTICE GUIDELINES FOR COMMUNITYSEE MORE ON

USPHARMACIST.COM

SMOKING CESSATION

The benefits of smoking cessation are many, including a rapid normalization of blood pressure and heart rate, improvement in breathing and blood circulation, and better lung function. Over the long term, smoking cessation means a much lower chance of developing many of the cancers caused by smoking. This includes cancer of the

lungs, throat

LITTLE EVIDENCE CERTAIN PAINKILLERS EXACERBATE CROHN’S Boston—Patients with Crohn’s disease and ulcerative colitis often are warned about the use of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) because of concerns that the painkillers could exacerbate their conditions. A new review in Alimentary Pharmacology & Therapeutics did not make a clear connection, however. “Contrary to generally accepted belief, a

recent review and

AVOIDING SHOULDER INJURY WHEN ADMINISTERING VACCINES Avoiding Shoulder Injury When Administering Vaccines. Shoulder injury related to vaccine administration (SIRVA) is a relatively rare adverse effect of an improperly administered vaccination. It occurs when an injection is administered too high in the arm and the vaccine is delivered to the shoulder capsule instead of the deltoid muscle

U.S. PHARMACIST

U.S. Pharmacist is the leading clinically-focused monthly pharmacy publication providing the nation's pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice. U.S. PHARMACIST WEEKLY NEWS UPDATE By Staff. U.S. Pharmacist Weekly News. May 12, 2021. ISMP Offers Tips on Avoiding Errors in COVID-19 Vaccine Administration. Certain errors are more common than others when administering COVID-19 vaccines, whether they involve check-in or preparation of the syringes. Find out what the Institute for Safe Medication Practices (ISMP) recommends to AUTHORIZED GENERICS: WHAT PHARMACISTS SHOULD KNOW Authorized Generics are a category of generic drugs made by the manufacturer of the brand name drug. They are the same as the brand name drug but do not use the brand name on the label and may have a different color or marking. 1. An Authorized Generic is marketed under the brand name drug’s New Drug Application (NDA) and is therefore

not

DO IMMUNOCOMPROMISED PATIENTS HAVE ENOUGH RESPONSE TO Baltimore, MD—Concerns are being raised about how effectively immunocompromised patients can mount an immune response after the first of two doses of a SARS-CoV-2 messenger RNA (mRNA) vaccine. A research letter published in JAMA suggests that, in those patients, the immune response to vaccination might be blunted. To add to understanding of that phenomenon, Johns MULTIPLE MYELOMA: AN OVERVIEW OF THE DISEASE AND TREATMENTSEE MORE ON

USPHARMACIST.COM

PHARMACIST CONSIDERATIONS FOR TREATING PATIENTS WITH ALS Hydrotherapy, heat, cold, electrical stimulation, chemodenervation, and surgery have been utilized to treat muscle spasticity. Physical therapy is the primary treatment for spasticity with positive evidence in ALS. 2 Pharmacotherapy with baclofen and tizanidine are typically

recommended.

UPDATED CLINICAL PRACTICE GUIDELINES FOR COMMUNITYSEE MORE ON

USPHARMACIST.COM

SMOKING CESSATION

The benefits of smoking cessation are many, including a rapid normalization of blood pressure and heart rate, improvement in breathing and blood circulation, and better lung function. Over the long term, smoking cessation means a much lower chance of developing many of the cancers caused by smoking. This includes cancer of the

lungs, throat

LITTLE EVIDENCE CERTAIN PAINKILLERS EXACERBATE CROHN’S Boston—Patients with Crohn’s disease and ulcerative colitis often are warned about the use of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) because of concerns that the painkillers could exacerbate their conditions. A new review in Alimentary Pharmacology & Therapeutics did not make a clear connection, however. “Contrary to generally accepted belief, a

recent review and

AVOIDING SHOULDER INJURY WHEN ADMINISTERING VACCINES Avoiding Shoulder Injury When Administering Vaccines. Shoulder injury related to vaccine administration (SIRVA) is a relatively rare adverse effect of an improperly administered vaccination. It occurs when an injection is administered too high in the arm and the vaccine is delivered to the shoulder capsule instead of the deltoid muscle PHARMACISTS SHOULD EXPECT TO ADMINISTER COVID-19 VACCINE Bethesda, MD—Pharmacists have been busy all year providing COVID-19 vaccines, and no end is in sight.One reason is the strong expectation that booster shots will be available in the fall for those who were vaccinated earlier this year. PROTON PUMP INHIBITORS AND COVID-19 Proton Pump Inhibitors and COVID-19. US Pharm. 2020;12 (45):26-2924. ABSTRACT: COVID-19 is a global respiratory disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2. It is associated with high mortality and morbidity and continues to place a great burden on the worldwide economy. U.S. PHARMACIST WEEKLY NEWS UPDATE Pharmacists won’t be putting down their syringes any time soon. Growing evidence suggests that, even before initial COVID-19 vaccine doses are provided to all age groups, booster shots will be available in the autumn for those who were immunized earlier in the year. COMMON SUPPLEMENTS MIGHT REDUCE COVID SEVERITY Melatonin is best known and most commonly used to boost sleep and reduce anxiety, both of which improve the immune system. It also blocks inflammasome activity, reducing inflammation in the lungs, and it reduces the risk of fibrosis, one of the most challenging complications for patients who have had COVID-19. Evidence for vitamin

D3 is mixed.

U.S. PHARMACIST WEEKLY NEWS UPDATE News about medications to treat COVID-19 came fast and furious at the height of the pandemic. Even pharmacists had trouble keeping up. Now, a new study focuses on a California health system to discuss which drugs actually were administered to patients with severe disease and how their use changed over time. MEDICATIONS IN WIDE USE FOR SEVERE COVID-19 CHANGED OVER During the height of the COVID-19 pandemic, new medications were constantly being touted as showing promise to ameliorate the symptoms—or even cure—the sometimes-deadly virus. PANDEMIC HAD DRAMATIC EFFECT ON CARE FOR PROSTATE-CANCER San Francisco, CA—While pharmacists currently are in the middle of the battle against COVID-19, providing vaccines and testing, their role at some point will shift to dealing with the aftermath of the viral outbreak. While some of that will be related to so-called long COVID, caring for patients whose symptoms continued after a viral infection, other efforts will be focused on the AUTHORIZED GENERICS: WHAT PHARMACISTS SHOULD KNOW Authorized Generics are a category of generic drugs made by the manufacturer of the brand name drug. They are the same as the brand name drug but do not use the brand name on the label and may have a different color or marking. 1. An Authorized Generic is marketed under the brand name drug’s New Drug Application (NDA) and is therefore

not

MANAGEMENT OF RADIATION-INDUCED NAUSEA AND VOMITING Nausea is a serious side effect of radiation therapy that can impact the patient’s quality of life. It is estimated that radiation induces nausea and vomiting in 50% to 80% of patients. Patients undergoing this therapy often receive up to 40 fractions of radiation in a 6- to 8-week period. Patients with radiation-induced nausea and

vomiting

GLENMARK PHARMACEUTICALS LAUNCHES RUFINAMIDE TABLETS USP Mumbai, India, June 1, 2021 – Glenmark Pharmaceuticals Limited (Glenmark) has launched Rufinamide Tablets USP, 200 mg and 400 mg, a therapeutic equivalent of Banzel ®1 Tablets, 200 mg and 400 mg of Eisai, Inc. Glenmark was one of the first ANDA applicants to submit a substantially complete ANDA for Rufinamide Tablets USP, 200 mg and 400 mg, with a paragraph IV certification and received

U.S. PHARMACIST

U.S. Pharmacist is the leading clinically-focused monthly pharmacy publication providing the nation's pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice. U.S. PHARMACIST WEEKLY NEWS UPDATE By Staff. U.S. Pharmacist Weekly News. May 12, 2021. ISMP Offers Tips on Avoiding Errors in COVID-19 Vaccine Administration. Certain errors are more common than others when administering COVID-19 vaccines, whether they involve check-in or preparation of the syringes. Find out what the Institute for Safe Medication Practices (ISMP) recommends to AUTHORIZED GENERICS: WHAT PHARMACISTS SHOULD KNOW Authorized Generics are a category of generic drugs made by the manufacturer of the brand name drug. They are the same as the brand name drug but do not use the brand name on the label and may have a different color or marking. 1. An Authorized Generic is marketed under the brand name drug’s New Drug Application (NDA) and is therefore

not

DO IMMUNOCOMPROMISED PATIENTS HAVE ENOUGH RESPONSE TO Baltimore, MD—Concerns are being raised about how effectively immunocompromised patients can mount an immune response after the first of two doses of a SARS-CoV-2 messenger RNA (mRNA) vaccine. A research letter published in JAMA suggests that, in those patients, the immune response to vaccination might be blunted. To add to understanding of that phenomenon, Johns MULTIPLE MYELOMA: AN OVERVIEW OF THE DISEASE AND TREATMENTSEE MORE ON

USPHARMACIST.COM

PHARMACIST CONSIDERATIONS FOR TREATING PATIENTS WITH ALS Hydrotherapy, heat, cold, electrical stimulation, chemodenervation, and surgery have been utilized to treat muscle spasticity. Physical therapy is the primary treatment for spasticity with positive evidence in ALS. 2 Pharmacotherapy with baclofen and tizanidine are typically

recommended.

UPDATED CLINICAL PRACTICE GUIDELINES FOR COMMUNITYSEE MORE ON

USPHARMACIST.COM

SMOKING CESSATION

The benefits of smoking cessation are many, including a rapid normalization of blood pressure and heart rate, improvement in breathing and blood circulation, and better lung function. Over the long term, smoking cessation means a much lower chance of developing many of the cancers caused by smoking. This includes cancer of the

lungs, throat

LITTLE EVIDENCE CERTAIN PAINKILLERS EXACERBATE CROHN’S Boston—Patients with Crohn’s disease and ulcerative colitis often are warned about the use of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) because of concerns that the painkillers could exacerbate their conditions. A new review in Alimentary Pharmacology & Therapeutics did not make a clear connection, however. “Contrary to generally accepted belief, a

recent review and

AVOIDING SHOULDER INJURY WHEN ADMINISTERING VACCINES Avoiding Shoulder Injury When Administering Vaccines. Shoulder injury related to vaccine administration (SIRVA) is a relatively rare adverse effect of an improperly administered vaccination. It occurs when an injection is administered too high in the arm and the vaccine is delivered to the shoulder capsule instead of the deltoid muscle

U.S. PHARMACIST

U.S. Pharmacist is the leading clinically-focused monthly pharmacy publication providing the nation's pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice. U.S. PHARMACIST WEEKLY NEWS UPDATE By Staff. U.S. Pharmacist Weekly News. May 12, 2021. ISMP Offers Tips on Avoiding Errors in COVID-19 Vaccine Administration. Certain errors are more common than others when administering COVID-19 vaccines, whether they involve check-in or preparation of the syringes. Find out what the Institute for Safe Medication Practices (ISMP) recommends to AUTHORIZED GENERICS: WHAT PHARMACISTS SHOULD KNOW Authorized Generics are a category of generic drugs made by the manufacturer of the brand name drug. They are the same as the brand name drug but do not use the brand name on the label and may have a different color or marking. 1. An Authorized Generic is marketed under the brand name drug’s New Drug Application (NDA) and is therefore

not

DO IMMUNOCOMPROMISED PATIENTS HAVE ENOUGH RESPONSE TO Baltimore, MD—Concerns are being raised about how effectively immunocompromised patients can mount an immune response after the first of two doses of a SARS-CoV-2 messenger RNA (mRNA) vaccine. A research letter published in JAMA suggests that, in those patients, the immune response to vaccination might be blunted. To add to understanding of that phenomenon, Johns MULTIPLE MYELOMA: AN OVERVIEW OF THE DISEASE AND TREATMENTSEE MORE ON

USPHARMACIST.COM

PHARMACIST CONSIDERATIONS FOR TREATING PATIENTS WITH ALS Hydrotherapy, heat, cold, electrical stimulation, chemodenervation, and surgery have been utilized to treat muscle spasticity. Physical therapy is the primary treatment for spasticity with positive evidence in ALS. 2 Pharmacotherapy with baclofen and tizanidine are typically

recommended.

UPDATED CLINICAL PRACTICE GUIDELINES FOR COMMUNITYSEE MORE ON

USPHARMACIST.COM

SMOKING CESSATION

The benefits of smoking cessation are many, including a rapid normalization of blood pressure and heart rate, improvement in breathing and blood circulation, and better lung function. Over the long term, smoking cessation means a much lower chance of developing many of the cancers caused by smoking. This includes cancer of the

lungs, throat

LITTLE EVIDENCE CERTAIN PAINKILLERS EXACERBATE CROHN’S Boston—Patients with Crohn’s disease and ulcerative colitis often are warned about the use of acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) because of concerns that the painkillers could exacerbate their conditions. A new review in Alimentary Pharmacology & Therapeutics did not make a clear connection, however. “Contrary to generally accepted belief, a

recent review and

AVOIDING SHOULDER INJURY WHEN ADMINISTERING VACCINES Avoiding Shoulder Injury When Administering Vaccines. Shoulder injury related to vaccine administration (SIRVA) is a relatively rare adverse effect of an improperly administered vaccination. It occurs when an injection is administered too high in the arm and the vaccine is delivered to the shoulder capsule instead of the deltoid muscle PHARMACISTS SHOULD EXPECT TO ADMINISTER COVID-19 VACCINE Bethesda, MD—Pharmacists have been busy all year providing COVID-19 vaccines, and no end is in sight.One reason is the strong expectation that booster shots will be available in the fall for those who were vaccinated earlier this year. PROTON PUMP INHIBITORS AND COVID-19 Proton Pump Inhibitors and COVID-19. US Pharm. 2020;12 (45):26-2924. ABSTRACT: COVID-19 is a global respiratory disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2. It is associated with high mortality and morbidity and continues to place a great burden on the worldwide economy. U.S. PHARMACIST WEEKLY NEWS UPDATE Pharmacists won’t be putting down their syringes any time soon. Growing evidence suggests that, even before initial COVID-19 vaccine doses are provided to all age groups, booster shots will be available in the autumn for those who were immunized earlier in the year. COMMON SUPPLEMENTS MIGHT REDUCE COVID SEVERITY Melatonin is best known and most commonly used to boost sleep and reduce anxiety, both of which improve the immune system. It also blocks inflammasome activity, reducing inflammation in the lungs, and it reduces the risk of fibrosis, one of the most challenging complications for patients who have had COVID-19. Evidence for vitamin

D3 is mixed.

U.S. PHARMACIST WEEKLY NEWS UPDATE News about medications to treat COVID-19 came fast and furious at the height of the pandemic. Even pharmacists had trouble keeping up. Now, a new study focuses on a California health system to discuss which drugs actually were administered to patients with severe disease and how their use changed over time. MEDICATIONS IN WIDE USE FOR SEVERE COVID-19 CHANGED OVER During the height of the COVID-19 pandemic, new medications were constantly being touted as showing promise to ameliorate the symptoms—or even cure—the sometimes-deadly virus. PANDEMIC HAD DRAMATIC EFFECT ON CARE FOR PROSTATE-CANCER San Francisco, CA—While pharmacists currently are in the middle of the battle against COVID-19, providing vaccines and testing, their role at some point will shift to dealing with the aftermath of the viral outbreak. While some of that will be related to so-called long COVID, caring for patients whose symptoms continued after a viral infection, other efforts will be focused on the AUTHORIZED GENERICS: WHAT PHARMACISTS SHOULD KNOW Authorized Generics are a category of generic drugs made by the manufacturer of the brand name drug. They are the same as the brand name drug but do not use the brand name on the label and may have a different color or marking. 1. An Authorized Generic is marketed under the brand name drug’s New Drug Application (NDA) and is therefore

not

MANAGEMENT OF RADIATION-INDUCED NAUSEA AND VOMITING Nausea is a serious side effect of radiation therapy that can impact the patient’s quality of life. It is estimated that radiation induces nausea and vomiting in 50% to 80% of patients. Patients undergoing this therapy often receive up to 40 fractions of radiation in a 6- to 8-week period. Patients with radiation-induced nausea and

vomiting

GLENMARK PHARMACEUTICALS LAUNCHES RUFINAMIDE TABLETS USP Mumbai, India, June 1, 2021 – Glenmark Pharmaceuticals Limited (Glenmark) has launched Rufinamide Tablets USP, 200 mg and 400 mg, a therapeutic equivalent of Banzel ®1 Tablets, 200 mg and 400 mg of Eisai, Inc. Glenmark was one of the first ANDA applicants to submit a substantially complete ANDA for Rufinamide Tablets USP, 200 mg and 400 mg, with a paragraph IV certification and received

U.S. PHARMACIST

U.S. Pharmacist is the leading clinically-focused monthly pharmacy publication providing the nation's pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice. MANAGEMENT OF RADIATION-INDUCED NAUSEA AND VOMITINGSEE MORE ON

USPHARMACIST.COM

PHARMACIST CONSIDERATIONS FOR TREATING PATIENTS WITH ALS Hydrotherapy, heat, cold, electrical stimulation, chemodenervation, and surgery have been utilized to treat muscle spasticity. Physical therapy is the primary treatment for spasticity with positive evidence in ALS. 2 Pharmacotherapy with baclofen and tizanidine are typically

recommended.

DISCUSSING BRAND VERSUS GENERIC MEDICATIONS Discussing Brand Versus Generic Medications. US Pharm. 2020;45 (6):30-32. ABSTRACT: The FDA defines a generic drug as a “medication created to be the same as an already marketed brand-name drug in dosage form, safety, strength, route of administration, quality, performance characteristics, and intended use.”. UPDATES IN THE MANAGEMENT OF CLOSTRIDIUM DIFFICILE FOR ADULTS Fidaxomicin. Fidaxomicin (Dificid) is a macrolide antibacterial drug that is bactericidal against C difficile in vitro, inhibiting RNA synthesis by RNA polymerases; it was approved in May 2011. It is indicated for adults aged 18 years and older for the treatment of C difficile –associated diarrhea. MEDICATIONS ASSOCIATED WITH IMPLANTABLE CARDIAC DEVICESSEE MORE ON

USPHARMACIST.COM

MANAGEMENT OF HYPONATREMIA: FOCUS ON PSYCHIATRIC PATIENTSSEE MORE ON

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INAPPROPRIATE USE OF SKELETAL MUSCLE RELAXANTS INSEE MORE ON

USPHARMACIST.COM

CAUSES OF SEIZURES IN THE ELDERLY There is a relatively high frequency of epilepsy in the elderly that is now being recognized. 1 While new-onset seizures are uncommon in geriatric patients, according to one study the three most common identifiable causes of acute symptomatic seizures in adults were alcohol withdrawal, strokes, and electrolyte disturbances. 2 Among all

age

ALTHOUGH SAFE FOR MOST, MELATONIN CAUSES UNEXPECTED Although Safe for Most, Melatonin Causes Unexpected Interactions in Others. By staff. More than one-third of Americans suffer from sleep deprivation, according to the National Institutes of Health. One in five has tried a natural remedy, generally melatonin, to sleep better, Consumer Reports found, driving sales of the hormone up to $425

U.S. PHARMACIST

U.S. Pharmacist is the leading clinically-focused monthly pharmacy publication providing the nation's pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice. MANAGEMENT OF RADIATION-INDUCED NAUSEA AND VOMITINGSEE MORE ON

USPHARMACIST.COM

PHARMACIST CONSIDERATIONS FOR TREATING PATIENTS WITH ALS Hydrotherapy, heat, cold, electrical stimulation, chemodenervation, and surgery have been utilized to treat muscle spasticity. Physical therapy is the primary treatment for spasticity with positive evidence in ALS. 2 Pharmacotherapy with baclofen and tizanidine are typically

recommended.

DISCUSSING BRAND VERSUS GENERIC MEDICATIONS Discussing Brand Versus Generic Medications. US Pharm. 2020;45 (6):30-32. ABSTRACT: The FDA defines a generic drug as a “medication created to be the same as an already marketed brand-name drug in dosage form, safety, strength, route of administration, quality, performance characteristics, and intended use.”. UPDATES IN THE MANAGEMENT OF CLOSTRIDIUM DIFFICILE FOR ADULTS Fidaxomicin. Fidaxomicin (Dificid) is a macrolide antibacterial drug that is bactericidal against C difficile in vitro, inhibiting RNA synthesis by RNA polymerases; it was approved in May 2011. It is indicated for adults aged 18 years and older for the treatment of C difficile –associated diarrhea. MEDICATIONS ASSOCIATED WITH IMPLANTABLE CARDIAC DEVICESSEE MORE ON

USPHARMACIST.COM

MANAGEMENT OF HYPONATREMIA: FOCUS ON PSYCHIATRIC PATIENTSSEE MORE ON

USPHARMACIST.COM

INAPPROPRIATE USE OF SKELETAL MUSCLE RELAXANTS INSEE MORE ON

USPHARMACIST.COM

CAUSES OF SEIZURES IN THE ELDERLY There is a relatively high frequency of epilepsy in the elderly that is now being recognized. 1 While new-onset seizures are uncommon in geriatric patients, according to one study the three most common identifiable causes of acute symptomatic seizures in adults were alcohol withdrawal, strokes, and electrolyte disturbances. 2 Among all

age

ALTHOUGH SAFE FOR MOST, MELATONIN CAUSES UNEXPECTED Although Safe for Most, Melatonin Causes Unexpected Interactions in Others. By staff. More than one-third of Americans suffer from sleep deprivation, according to the National Institutes of Health. One in five has tried a natural remedy, generally melatonin, to sleep better, Consumer Reports found, driving sales of the hormone up to $425 U.S. PHARMACIST WEEKLY NEWS News about medications to treat COVID-19 came fast and furious at the height of the pandemic. Even pharmacists had trouble keeping up. Now, a new study focuses on a California health system to discuss which drugs actually were administered to patients with severe disease and how their use changed over time. MEDICATIONS IN WIDE USE FOR SEVERE COVID-19 CHANGED OVER During the height of the COVID-19 pandemic, new medications were constantly being touted as showing promise to ameliorate the symptoms—or even cure—the sometimes-deadly virus. U.S. PHARMACIST WEEKLY NEWS UPDATE News about medications to treat COVID-19 came fast and furious at the height of the pandemic. Even pharmacists had trouble keeping up. Now, a new study focuses on a California health system to discuss which drugs actually were administered to patients with severe disease and how their use changed over time. DISCUSSING BRAND VERSUS GENERIC MEDICATIONS Discussing Brand Versus Generic Medications. US Pharm. 2020;45 (6):30-32. ABSTRACT: The FDA defines a generic drug as a “medication created to be the same as an already marketed brand-name drug in dosage form, safety, strength, route of administration, quality, performance characteristics, and intended use.”. UPDATES IN THE MANAGEMENT OF CLOSTRIDIUM DIFFICILE FOR ADULTS Fidaxomicin. Fidaxomicin (Dificid) is a macrolide antibacterial drug that is bactericidal against C difficile in vitro, inhibiting RNA synthesis by RNA polymerases; it was approved in May 2011. It is indicated for adults aged 18 years and older for the treatment of C difficile –associated diarrhea. PARENTERAL IRONS: INDICATIONS AND COMPARISON Parenteral Irons: Indications and Comparison. US Pharm. 2010;35 (11):HS-22-HS-24. To make healthy red blood cells, the human body needs to have enough iron. The most common cause of anemia in the United States is iron deficiency, which is resolved by eating iron in a healthy diet, taking iron pills, and, in severe cases, receiving

iron injections.

MEDICATIONS ASSOCIATED WITH IMPLANTABLE CARDIAC DEVICES US Pharm. 2016;41(2):30-34.. ABSTRACT: Implantable cardiac devices are a mainstay in treating cardiac diseases and include pacemakers, cardioverter defibrillators, and cardiac resynchronization therapy. Some drugs can interfere with these devices, while certain medications can prevent inappropriate shocks from the devices. Care should be taken to treat and prevent infections MANAGEMENT OF HYPONATREMIA: FOCUS ON PSYCHIATRIC PATIENTS Hyponatremia induced by SIADH (syndrome of inappropriate antidiuretic hormone secretion) and psychogenic polydipsia require significant pharmacist interventions and are frequently seen in psychiatric patients. Hyponatremia, defined as serum sodium (Na +) < 136 mmol/L, is the most commonly encountered electrolyte disorder in clinical

practice

GLENMARK PHARMACEUTICALS LAUNCHES RUFINAMIDE TABLETS USP Mumbai, India, June 1, 2021 – Glenmark Pharmaceuticals Limited (Glenmark) has launched Rufinamide Tablets USP, 200 mg and 400 mg, a therapeutic equivalent of Banzel ®1 Tablets, 200 mg and 400 mg of Eisai, Inc. Glenmark was one of the first ANDA applicants to submit a substantially complete ANDA for Rufinamide Tablets USP, 200 mg and 400 mg, with a paragraph IV certification and received IS THE 21-GENE ASSAY USEFUL IN PREDICTING ENDOCRINE A recent systematic review and meta-analysis was performed to compare responses to neoadjuvant endocrine therapy (NET) in patients with estrogen receptor-positive, human epidermal growth factor receptor-negative (ER+/HER2-) breast cancer (BC) following stratification by recurrence score (RS) testing. The investigators hypothesized that the RS might determine patients who are more

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