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ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV ČR 5. května 2021. V březnu představili vědci ze Skupiny Jana Konvalinky při Ústavu organické chemie a biochemie AV ČR novou metodu pro rychlou a snadnou analýzu antigenních testů na SARS-CoV-2, v. Přejít na článek. Těžká voda chutná sladce. 7.dubna 2021.
HISTORY - UOCHB.CZ
The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague. LEADERSHIP & STRUCTURE Leadership. Official bodies of IOCB are the Board of the institute, which serves as an advisory authority to the Director and decides on essential scientific issues, the Supervisory board monitoring financial and legal matters and the director, who acts as a statutory body on behalf of the institute. Management. IOCB Board. SupervisoryBoard.
REMEMBERING JOHN C. MARTIN “John C. Martin was a chemist by education and a businessman by profession. However, from the bottom of his heart he was especially an enterprising adventurer with an excellent instinct for recognizing the potential of promising substances and great business opportunities,” says Zdeněk Hostomský, director of IOCB.“Only thanks to his dedication, foresight, perseverance, but also his LONGHORN BEETLES (CERAMBYCIDAE, COLEOPTERA) OF THE WEST regularly updated encyclopedia containing information about more than 1010 West Palaearctic & former USSR Cerambycidoea taxa; the web site, completely recoded and reshaped during spring 2016, is on-line continuously from 1997 on the same URL CHEMISTRY OF NATURAL PRODUCTS The group’s interests focus to a large extent on the total synthesis of natural products and their biological investigation. We are interested on one hand in establishment and confirmation of the structures of natural products, on the other hand innovative approaches to access them in reasonable amounts for biological investigations are pursued. CHEMISTRY OF FUNCTIONAL MOLECULES We investigate systematically their (chir)optical properties, self-assembly in crystals or at interfaces, charge/spin transport properties and on-surface reactivity at nanoscale. We are also interested in the general synthetic methodology development and enantioselective catalysis. Our ultimate goal is to develop smartmolecular devices.
BIOCHEMISTRY OF PLANT SPECIALIZED METABOLITES During millions of years of evolution, land plants have created an astonishing variety of bioactive specialized metabolites (also referred to as ‘secondary metabolites’ or ‘natural products’) to support their defense and ecological adaptation. Such molecules represent an important source of chemical scaffolds for thedevelopment of new
ING. DANA HOCKOVÁ, CSC. Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganická INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE CASABOUT USRESEARCHSTUDY & CAREERNEWSEVENTSTECH TRANSFER Institute of Organic Chemistry. and Biochemistry of the CAS. Partnership with Alzheon to develop first Alzheimer’s diagnostic assay for measuring neurotoxic. 6 May 2021. IOCB Prague entered into a collaboration and license agreement with Alzheon, Inc., a clinical-stage biopharmaceutical company focused on developing newmedicines for
ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV ČR 5. května 2021. V březnu představili vědci ze Skupiny Jana Konvalinky při Ústavu organické chemie a biochemie AV ČR novou metodu pro rychlou a snadnou analýzu antigenních testů na SARS-CoV-2, v. Přejít na článek. Těžká voda chutná sladce. 7.dubna 2021.
HISTORY - UOCHB.CZ
The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague. LEADERSHIP & STRUCTURE Leadership. Official bodies of IOCB are the Board of the institute, which serves as an advisory authority to the Director and decides on essential scientific issues, the Supervisory board monitoring financial and legal matters and the director, who acts as a statutory body on behalf of the institute. Management. IOCB Board. SupervisoryBoard.
REMEMBERING JOHN C. MARTIN “John C. Martin was a chemist by education and a businessman by profession. However, from the bottom of his heart he was especially an enterprising adventurer with an excellent instinct for recognizing the potential of promising substances and great business opportunities,” says Zdeněk Hostomský, director of IOCB.“Only thanks to his dedication, foresight, perseverance, but also his LONGHORN BEETLES (CERAMBYCIDAE, COLEOPTERA) OF THE WEST regularly updated encyclopedia containing information about more than 1010 West Palaearctic & former USSR Cerambycidoea taxa; the web site, completely recoded and reshaped during spring 2016, is on-line continuously from 1997 on the same URL CHEMISTRY OF NATURAL PRODUCTS The group’s interests focus to a large extent on the total synthesis of natural products and their biological investigation. We are interested on one hand in establishment and confirmation of the structures of natural products, on the other hand innovative approaches to access them in reasonable amounts for biological investigations are pursued. CHEMISTRY OF FUNCTIONAL MOLECULES We investigate systematically their (chir)optical properties, self-assembly in crystals or at interfaces, charge/spin transport properties and on-surface reactivity at nanoscale. We are also interested in the general synthetic methodology development and enantioselective catalysis. Our ultimate goal is to develop smartmolecular devices.
BIOCHEMISTRY OF PLANT SPECIALIZED METABOLITES During millions of years of evolution, land plants have created an astonishing variety of bioactive specialized metabolites (also referred to as ‘secondary metabolites’ or ‘natural products’) to support their defense and ecological adaptation. Such molecules represent an important source of chemical scaffolds for thedevelopment of new
ING. DANA HOCKOVÁ, CSC. Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganická LEADERSHIP & STRUCTURE Leadership. Official bodies of IOCB are the Board of the institute, which serves as an advisory authority to the Director and decides on essential scientific issues, the Supervisory board monitoring financial and legal matters and the director, who acts as a statutory body on behalf of the institute. Management. IOCB Board. SupervisoryBoard.
COPPER-TRIAZOLE COCKTAIL EFFECT INVESTIGATED Copper-triazole cocktail effect investigated. 2 September 2020. Common triazole fungicides tebuconazole, cyproconazole, and penconazole were originally developed to inhibit demethylase, thus stifling the production of ergosterol, which is important for GILEAD SCIENCES RESEARCH CENTRE Gilead Sciences Research Centre. Počátky jedinečné spolupráce mezi ÚOCHB a americkou farmaceutickou společností Gilead Sciences se datují do počátků devadesátých let minulého století. V roce 2006 byl zahájen partnerský program nazvaný Gilead Sciences Research Centre, v jehož rámci Gilead poskytoval ústavu po dobupěti let
BRUKER AVANCE III™ HD 400 MHZ Bruker Avance III™ HD 400 MHz Prodigy. The 400 MHz NMR spectrometer equipped with a sensitive nitrogen cooled broadband 5 mm probe and an automatic sample changer of 60 samples. It is used as a routine spectrometer for self-service liquid phase NMR measurements. Bruker Avance II™ 500 MHz. The NMR spectrometer created by rebuilding aVarian
BRUKER AVANCE III™ HD 600 MHZ Bruker Avance III™ HD 600 MHz. NMR Spectroscopy. The 600 MHz NMR spectrometer is used in the structural analysis of small molecules, but it also allows the study of protein structure. Designed for liquid phase measurements and equipped with 5 mm and 1.7 mm sensitive helium probes (this one is currently the most sensitive commercially BRUKER AVANCE III™ HD 500 MHZ Bruker Avance III™ HD 400 MHz. The second 400 MHz NMR spectrometer designed for self-service measurement in the liquid phase is equipped with a wideband 5 mm probe and an automatic 120 sample changer. Bruker Avance II™ 500 MHz. The NMR spectrometer created by rebuilding a Varian spectrometer installed at IOCB in 1989. O NÁS - IOCBTRANSLATE THIS PAGE ÚOCHB byl založen jako multioborový ústav na pomezí chemie, biologie a medicíny, kde biologické i chemické skupiny a týmy spolupracují na společných tématech. Tento přístup přinesl významné úspěchy díky průkopnickému špičkovému výzkumu i praktickým aplikacím, zejména v JEOL JEM-1011 TRANSMISSION ELECTRON MICROSCOPE JEOL JEM-1011 Transmission Electron Microscope. The JEM-1011 is a compact high performance TEM with advanced features and functions. Its high contrast objective lens polepiece combines the highest possible contrast and brightness with optimum resolution. The JEOL patented cool beam gun allows high-brightness, high coherence illumination DRUG DESIGN AND MEDICINAL CHEMISTRY The primary objective of our work is to design and synthesize new molecules as potential therapeutics and as tools for chemical biology. The research in our lab focuses on development of novel means of deciphering biological processes connected with viral replication such as host-virus interaction or control of innate immunity related toviral infection.
ING. DANA HOCKOVÁ, CSC. Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganická INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE CASABOUT USRESEARCHSTUDY & CAREERNEWSEVENTSTECH TRANSFER Institute of Organic Chemistry. and Biochemistry of the CAS. Partnership with Alzheon to develop first Alzheimer’s diagnostic assay for measuring neurotoxic. 6 May 2021. IOCB Prague entered into a collaboration and license agreement with Alzheon, Inc., a clinical-stage biopharmaceutical company focused on developing newmedicines for
ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV ČR 5. května 2021. V březnu představili vědci ze Skupiny Jana Konvalinky při Ústavu organické chemie a biochemie AV ČR novou metodu pro rychlou a snadnou analýzu antigenních testů na SARS-CoV-2, v. Přejít na článek. Těžká voda chutná sladce. 7.dubna 2021.
HISTORY - UOCHB.CZ
The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague. REMEMBERING JOHN C. MARTIN “John C. Martin was a chemist by education and a businessman by profession. However, from the bottom of his heart he was especially an enterprising adventurer with an excellent instinct for recognizing the potential of promising substances and great business opportunities,” says Zdeněk Hostomský, director of IOCB.“Only thanks to his dedication, foresight, perseverance, but also his JUNIOR GROUP LEADER POSITION IN ORGANIC SYNTHESIS Job description. IOCB Prague invites applications for a Junior Group Leader position in synthetic organic chemistry with a strong emphasis on synthetic approaches to complex target molecules at the interface of chemistry and biology. This tenure-track position is comparable to assistant professor at a US university, or to a new investigator CHEMISTRY OF NATURAL PRODUCTS The group’s interests focus to a large extent on the total synthesis of natural products and their biological investigation. We are interested on one hand in establishment and confirmation of the structures of natural products, on the other hand innovative approaches to access them in reasonable amounts for biological investigations are pursued. LONGHORN BEETLES (CERAMBYCIDAE, COLEOPTERA) OF THE WEST regularly updated encyclopedia containing information about more than 1010 West Palaearctic & former USSR Cerambycidoea taxa; the web site, completely recoded and reshaped during spring 2016, is on-line continuously from 1997 on the same URLERIK ANDRIS
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
BIOCHEMISTRY OF PLANT SPECIALIZED METABOLITES During millions of years of evolution, land plants have created an astonishing variety of bioactive specialized metabolites (also referred to as ‘secondary metabolites’ or ‘natural products’) to support their defense and ecological adaptation. Such molecules represent an important source of chemical scaffolds for thedevelopment of new
PHYMATODES LIVIDUS
April - July. Host plant: polyphagous in deciduous trees ( Quercus, Castanea, Fagus etc.) Distribution: SW/SE Europe, Asia Minor, North Africa, Caucasus. The mounted beetle was beaten from oaks (Quercus) in Erdemli (S Turkey). The living one was collected in Sussargues (Hérault, France). Collected by our friends Petr Moravec andJean-Yves Rasplus.
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE CASABOUT USRESEARCHSTUDY & CAREERNEWSEVENTSTECH TRANSFER Institute of Organic Chemistry. and Biochemistry of the CAS. Partnership with Alzheon to develop first Alzheimer’s diagnostic assay for measuring neurotoxic. 6 May 2021. IOCB Prague entered into a collaboration and license agreement with Alzheon, Inc., a clinical-stage biopharmaceutical company focused on developing newmedicines for
ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV ČR 5. května 2021. V březnu představili vědci ze Skupiny Jana Konvalinky při Ústavu organické chemie a biochemie AV ČR novou metodu pro rychlou a snadnou analýzu antigenních testů na SARS-CoV-2, v. Přejít na článek. Těžká voda chutná sladce. 7.dubna 2021.
HISTORY - UOCHB.CZ
The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague. REMEMBERING JOHN C. MARTIN “John C. Martin was a chemist by education and a businessman by profession. However, from the bottom of his heart he was especially an enterprising adventurer with an excellent instinct for recognizing the potential of promising substances and great business opportunities,” says Zdeněk Hostomský, director of IOCB.“Only thanks to his dedication, foresight, perseverance, but also his JUNIOR GROUP LEADER POSITION IN ORGANIC SYNTHESIS Job description. IOCB Prague invites applications for a Junior Group Leader position in synthetic organic chemistry with a strong emphasis on synthetic approaches to complex target molecules at the interface of chemistry and biology. This tenure-track position is comparable to assistant professor at a US university, or to a new investigator CHEMISTRY OF NATURAL PRODUCTS The group’s interests focus to a large extent on the total synthesis of natural products and their biological investigation. We are interested on one hand in establishment and confirmation of the structures of natural products, on the other hand innovative approaches to access them in reasonable amounts for biological investigations are pursued. LONGHORN BEETLES (CERAMBYCIDAE, COLEOPTERA) OF THE WEST regularly updated encyclopedia containing information about more than 1010 West Palaearctic & former USSR Cerambycidoea taxa; the web site, completely recoded and reshaped during spring 2016, is on-line continuously from 1997 on the same URLERIK ANDRIS
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
BIOCHEMISTRY OF PLANT SPECIALIZED METABOLITES During millions of years of evolution, land plants have created an astonishing variety of bioactive specialized metabolites (also referred to as ‘secondary metabolites’ or ‘natural products’) to support their defense and ecological adaptation. Such molecules represent an important source of chemical scaffolds for thedevelopment of new
PHYMATODES LIVIDUS
April - July. Host plant: polyphagous in deciduous trees ( Quercus, Castanea, Fagus etc.) Distribution: SW/SE Europe, Asia Minor, North Africa, Caucasus. The mounted beetle was beaten from oaks (Quercus) in Erdemli (S Turkey). The living one was collected in Sussargues (Hérault, France). Collected by our friends Petr Moravec andJean-Yves Rasplus.
COPPER-TRIAZOLE COCKTAIL EFFECT INVESTIGATED Copper-triazole cocktail effect investigated. 2 September 2020. Common triazole fungicides tebuconazole, cyproconazole, and penconazole were originally developed to inhibit demethylase, thus stifling the production of ergosterol, which is important for BRUKER AVANCE III™ HD 600 MHZ Bruker Avance III™ HD 600 MHz. NMR Spectroscopy. The 600 MHz NMR spectrometer is used in the structural analysis of small molecules, but it also allows the study of protein structure. Designed for liquid phase measurements and equipped with 5 mm and 1.7 mm sensitive helium probes (this one is currently the most sensitive commercially JEOL JEM-1011 TRANSMISSION ELECTRON MICROSCOPE JEOL JEM-1011 Transmission Electron Microscope. The JEM-1011 is a compact high performance TEM with advanced features and functions. Its high contrast objective lens polepiece combines the highest possible contrast and brightness with optimum resolution. The JEOL patented cool beam gun allows high-brightness, high coherence illumination CHEMISTRY OF FUNCTIONAL MOLECULES We investigate systematically their (chir)optical properties, self-assembly in crystals or at interfaces, charge/spin transport properties and on-surface reactivity at nanoscale. We are also interested in the general synthetic methodology development and enantioselective catalysis. Our ultimate goal is to develop smartmolecular devices.
ING. DANA HOCKOVÁ, CSC. Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganická EXOCENTRUS STIERLINI Exocentrus stierlini is ecologically associated with willows ( Salix spp.). Beetles fly from June through August. They infest thin shoots 0.6-2.2 cm diameter of viable and decaying willow trees. Larvae hatching from eggs bore into wood, leaving small inlet on surface, and plug it with fine frass.LEPTUROBOSCA VIRENS
Adults in: June - August. Host plant: polyphagous in coniferous and deciduous trees ( Picea, Pinus, Abies, Betula) Distribution: mountains of Europe and Russia. The depicted beetles were collected on flowers (Apiaceae) in Tichá Dolina (West High Tatra Mts., North Slovakia). Collected by M.Hoskovec. Subfamilia: Lepturinae Latreille, 1802.PHYTOECIA ICTERICA
Adults in: April - July. Host plant: oligophagous in Apiaceae plants ( Pastinacia, Daucus, Pimpinella, Heracleum etc.) Distribution: Europe, Turkey, Caucasus, Russia. The mounted beetle was collected on Pastinacia in Štúrovo (South Slovakia). Images of larva and pupa canbe
ROPALOPUS FEMORATUS
Ropalopus femoratus only occurs in Europe. Locally it is quite frequent. It develops in dry thin twigs of various deciduous trees and shrubs. Very frequently in our climate it attacks dead or dying twigs of Corylus avellana and Quercus spp. Larvae feed subcortically creating broad galleries and later they build a shallow pupal cell in the sapwood. Life-cycle 2 years, adults occur from the end ACANTHOCINUS GRISEUS Acanthocinus griseus is widespread species of coniferous, mainly spruce forests of all categories. Larval development under bark of weakened, uprooted, freshly felled or even standing trees with fresh phloem. Data on the development of larvae in completely dry wood is not based on reality, the wood must contain at least a littlemoisture.
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE CASABOUT USRESEARCHSTUDY & CAREERNEWSEVENTSTECH TRANSFER Institute of Organic Chemistry. and Biochemistry of the CAS. Partnership with Alzheon to develop first Alzheimer’s diagnostic assay for measuring neurotoxic. 6 May 2021. IOCB Prague entered into a collaboration and license agreement with Alzheon, Inc., a clinical-stage biopharmaceutical company focused on developing newmedicines for
ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV ČR 5. května 2021. V březnu představili vědci ze Skupiny Jana Konvalinky při Ústavu organické chemie a biochemie AV ČR novou metodu pro rychlou a snadnou analýzu antigenních testů na SARS-CoV-2, v. Přejít na článek. Těžká voda chutná sladce. 7.dubna 2021.
HISTORY - UOCHB.CZ
The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague. REMEMBERING JOHN C. MARTIN Remembering John C. Martin. On 30 March 2021, John C. Martin, former executive chairman and CEO of Gilead Sciences, has passed away. Dr. Martin was one of the key figures without whom some of the most important antivirals used to combat HIV or HBV, originating in Antonín Holý’s lab at IOCB Prague, would never exist. BRUKER AVANCE III™ HD 600 MHZ Bruker Avance III™ HD 600 MHz. NMR Spectroscopy. The 600 MHz NMR spectrometer is used in the structural analysis of small molecules, but it also allows the study of protein structure. Designed for liquid phase measurements and equipped with 5 mm and 1.7 mm sensitive helium probes (this one is currently the most sensitive commercially CHEMISTRY OF NATURAL PRODUCTS The group’s interests focus to a large extent on the total synthesis of natural products and their biological investigation. We are interested on one hand in establishment and confirmation of the structures of natural products, on the other hand innovative approaches to access them in reasonable amounts for biological investigations are pursued. LONGHORN BEETLES (CERAMBYCIDAE, COLEOPTERA) OF THE WEST regularly updated encyclopedia containing information about more than 1010 West Palaearctic & former USSR Cerambycidoea taxa; the web site, completely recoded and reshaped during spring 2016, is on-line continuously from 1997 on the same URL CHEMISTRY OF FUNCTIONAL MOLECULES We investigate systematically their (chir)optical properties, self-assembly in crystals or at interfaces, charge/spin transport properties and on-surface reactivity at nanoscale. We are also interested in the general synthetic methodology development and enantioselective catalysis. Our ultimate goal is to develop smartmolecular devices.
BIOCHEMISTRY OF PLANT SPECIALIZED METABOLITES During millions of years of evolution, land plants have created an astonishing variety of bioactive specialized metabolites (also referred to as ‘secondary metabolites’ or ‘natural products’) to support their defense and ecological adaptation. Such molecules represent an important source of chemical scaffolds for thedevelopment of new
ING. DANA HOCKOVÁ, CSC. Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganická INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE CASABOUT USRESEARCHSTUDY & CAREERNEWSEVENTSTECH TRANSFER Institute of Organic Chemistry. and Biochemistry of the CAS. Partnership with Alzheon to develop first Alzheimer’s diagnostic assay for measuring neurotoxic. 6 May 2021. IOCB Prague entered into a collaboration and license agreement with Alzheon, Inc., a clinical-stage biopharmaceutical company focused on developing newmedicines for
ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV ČR 5. května 2021. V březnu představili vědci ze Skupiny Jana Konvalinky při Ústavu organické chemie a biochemie AV ČR novou metodu pro rychlou a snadnou analýzu antigenních testů na SARS-CoV-2, v. Přejít na článek. Těžká voda chutná sladce. 7.dubna 2021.
HISTORY - UOCHB.CZ
The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague. REMEMBERING JOHN C. MARTIN Remembering John C. Martin. On 30 March 2021, John C. Martin, former executive chairman and CEO of Gilead Sciences, has passed away. Dr. Martin was one of the key figures without whom some of the most important antivirals used to combat HIV or HBV, originating in Antonín Holý’s lab at IOCB Prague, would never exist. BRUKER AVANCE III™ HD 600 MHZ Bruker Avance III™ HD 600 MHz. NMR Spectroscopy. The 600 MHz NMR spectrometer is used in the structural analysis of small molecules, but it also allows the study of protein structure. Designed for liquid phase measurements and equipped with 5 mm and 1.7 mm sensitive helium probes (this one is currently the most sensitive commercially CHEMISTRY OF NATURAL PRODUCTS The group’s interests focus to a large extent on the total synthesis of natural products and their biological investigation. We are interested on one hand in establishment and confirmation of the structures of natural products, on the other hand innovative approaches to access them in reasonable amounts for biological investigations are pursued. LONGHORN BEETLES (CERAMBYCIDAE, COLEOPTERA) OF THE WEST regularly updated encyclopedia containing information about more than 1010 West Palaearctic & former USSR Cerambycidoea taxa; the web site, completely recoded and reshaped during spring 2016, is on-line continuously from 1997 on the same URL CHEMISTRY OF FUNCTIONAL MOLECULES We investigate systematically their (chir)optical properties, self-assembly in crystals or at interfaces, charge/spin transport properties and on-surface reactivity at nanoscale. We are also interested in the general synthetic methodology development and enantioselective catalysis. Our ultimate goal is to develop smartmolecular devices.
BIOCHEMISTRY OF PLANT SPECIALIZED METABOLITES During millions of years of evolution, land plants have created an astonishing variety of bioactive specialized metabolites (also referred to as ‘secondary metabolites’ or ‘natural products’) to support their defense and ecological adaptation. Such molecules represent an important source of chemical scaffolds for thedevelopment of new
ING. DANA HOCKOVÁ, CSC. Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganická LEADERSHIP & STRUCTURE Leadership. Official bodies of IOCB are the Board of the institute, which serves as an advisory authority to the Director and decides on essential scientific issues, the Supervisory board monitoring financial and legal matters and the director, who acts as a statutory body on behalf of the institute. Management. IOCB Board. SupervisoryBoard.
HISTORY - UOCHB.CZ
The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague.RESEARCH GROUPS
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
KONTAKT - IOCB PRAGUETRANSLATE THIS PAGE Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganická JEOL JEM-1011 TRANSMISSION ELECTRON MICROSCOPE JEOL JEM-1011 Transmission Electron Microscope. The JEM-1011 is a compact high performance TEM with advanced features and functions. Its high contrast objective lens polepiece combines the highest possible contrast and brightness with optimum resolution. The JEOL patented cool beam gun allows high-brightness, high coherence illuminationMARTIN JINEK
These studies have established a structural framework for engineering novel Cas9 variants with altered PAM specificities. More recently, we have focused on Cas12a (Cpf1), another RNA-guided nuclease enzyme that has emerged as a complementary genome editing tool to Cas9. DRUG DESIGN AND MEDICINAL CHEMISTRY The primary objective of our work is to design and synthesize new molecules as potential therapeutics and as tools for chemical biology. The research in our lab focuses on development of novel means of deciphering biological processes connected with viral replication such as host-virus interaction or control of innate immunity related toviral infection.
VÝZNAMNÉ ÚSPĚCHY úspěšné účinné látky: 5-azacytidin (komerční název VIDAZA), 5-aza-2'-deoxycitidin/decitabin (DACOGEN) patentovány a publikovány na ÚOCHB v polovině šedesátých let 20. století (trvalo dalších 40 let, než byly uvedeny na trh jako léčivé přípravky pro vzácná onemocnění, dlouho poté, co platnost původních patentůTOMÁŠ PLUSKAL
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
ADVANCED OPTICAL MICROSCOPY Josef Lazar Group was terminated as of 31 December 2020. The content of this page is no longer updated and serves for archive purposes only. The Laboratory of Advanced Optical Microscopy develops advanced techniques of optical microscopy and uses them to gain information about mechanisms of molecular processes taking place in living cellsand organisms.
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE CASABOUT USRESEARCHSTUDY & CAREERNEWSEVENTSTECH TRANSFER Institute of Organic Chemistry. and Biochemistry of the CAS. Partnership with Alzheon to develop first Alzheimer’s diagnostic assay for measuring neurotoxic. 6 May 2021. IOCB Prague entered into a collaboration and license agreement with Alzheon, Inc., a clinical-stage biopharmaceutical company focused on developing newmedicines for
ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV ČR V březnu představili vědci ze Skupiny Jana Konvalinky při Ústavu organické chemie a biochemie AV ČR novou metodu pro rychlou a snadnou analýzu antigenních testů na SARS-CoV-2, v. Ústav organické chemie a biochemie AV ČR přijímá přihlášky na pozici vedoucí/ho juniorské skupiny v oboru organické chemie s důrazem na REMEMBERING JOHN C. MARTIN Remembering John C. Martin. On 30 March 2021, John C. Martin, former executive chairman and CEO of Gilead Sciences, has passed away. Dr. Martin was one of the key figures without whom some of the most important antivirals used to combat HIV or HBV, originating in Antonín Holý’s lab at IOCB Prague, would never exist.HISTORY - UOCHB.CZ
The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague. CHEMISTRY OF NATURAL PRODUCTS The group’s interests focus to a large extent on the total synthesis of natural products and their biological investigation. We are interested on one hand in establishment and confirmation of the structures of natural products, on the other hand innovative approaches to access them in reasonable amounts for biological investigations are pursued. LONGHORN BEETLES (CERAMBYCIDAE, COLEOPTERA) OF THE WEST regularly updated encyclopedia containing information about more than 1010 West Palaearctic & former USSR Cerambycidoea taxa; the web site, completely recoded and reshaped during spring 2016, is on-line continuously from 1997 on the same URLTOMÁŠ PLUSKAL
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
ERIK ANDRIS
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
BIOCHEMISTRY OF PLANT SPECIALIZED METABOLITES During millions of years of evolution, land plants have created an astonishing variety of bioactive specialized metabolites (also referred to as ‘secondary metabolites’ or ‘natural products’) to support their defense and ecological adaptation. Such molecules represent an important source of chemical scaffolds for thedevelopment of new
PHYMATODES LIVIDUS
April - July. Host plant: polyphagous in deciduous trees ( Quercus, Castanea, Fagus etc.) Distribution: SW/SE Europe, Asia Minor, North Africa, Caucasus. The mounted beetle was beaten from oaks (Quercus) in Erdemli (S Turkey). The living one was collected in Sussargues (Hérault, France). Collected by our friends Petr Moravec andJean-Yves Rasplus.
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE CASABOUT USRESEARCHSTUDY & CAREERNEWSEVENTSTECH TRANSFER Institute of Organic Chemistry. and Biochemistry of the CAS. Partnership with Alzheon to develop first Alzheimer’s diagnostic assay for measuring neurotoxic. 6 May 2021. IOCB Prague entered into a collaboration and license agreement with Alzheon, Inc., a clinical-stage biopharmaceutical company focused on developing newmedicines for
ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV ČR V březnu představili vědci ze Skupiny Jana Konvalinky při Ústavu organické chemie a biochemie AV ČR novou metodu pro rychlou a snadnou analýzu antigenních testů na SARS-CoV-2, v. Ústav organické chemie a biochemie AV ČR přijímá přihlášky na pozici vedoucí/ho juniorské skupiny v oboru organické chemie s důrazem na REMEMBERING JOHN C. MARTIN Remembering John C. Martin. On 30 March 2021, John C. Martin, former executive chairman and CEO of Gilead Sciences, has passed away. Dr. Martin was one of the key figures without whom some of the most important antivirals used to combat HIV or HBV, originating in Antonín Holý’s lab at IOCB Prague, would never exist.HISTORY - UOCHB.CZ
The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague. CHEMISTRY OF NATURAL PRODUCTS The group’s interests focus to a large extent on the total synthesis of natural products and their biological investigation. We are interested on one hand in establishment and confirmation of the structures of natural products, on the other hand innovative approaches to access them in reasonable amounts for biological investigations are pursued. LONGHORN BEETLES (CERAMBYCIDAE, COLEOPTERA) OF THE WEST regularly updated encyclopedia containing information about more than 1010 West Palaearctic & former USSR Cerambycidoea taxa; the web site, completely recoded and reshaped during spring 2016, is on-line continuously from 1997 on the same URLTOMÁŠ PLUSKAL
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
ERIK ANDRIS
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
BIOCHEMISTRY OF PLANT SPECIALIZED METABOLITES During millions of years of evolution, land plants have created an astonishing variety of bioactive specialized metabolites (also referred to as ‘secondary metabolites’ or ‘natural products’) to support their defense and ecological adaptation. Such molecules represent an important source of chemical scaffolds for thedevelopment of new
PHYMATODES LIVIDUS
April - July. Host plant: polyphagous in deciduous trees ( Quercus, Castanea, Fagus etc.) Distribution: SW/SE Europe, Asia Minor, North Africa, Caucasus. The mounted beetle was beaten from oaks (Quercus) in Erdemli (S Turkey). The living one was collected in Sussargues (Hérault, France). Collected by our friends Petr Moravec andJean-Yves Rasplus.
BRUKER AVANCE III™ HD 600 MHZ Bruker Avance III™ HD 600 MHz. NMR Spectroscopy. The 600 MHz NMR spectrometer is used in the structural analysis of small molecules, but it also allows the study of protein structure. Designed for liquid phase measurements and equipped with 5 mm and 1.7 mm sensitive helium probes (this one is currently the most sensitive commercially JEOL JEM-1011 TRANSMISSION ELECTRON MICROSCOPE JEOL JEM-1011 Transmission Electron Microscope. The JEM-1011 is a compact high performance TEM with advanced features and functions. Its high contrast objective lens polepiece combines the highest possible contrast and brightness with optimum resolution. The JEOL patented cool beam gun allows high-brightness, high coherence illumination CHEMISTRY OF FUNCTIONAL MOLECULES We investigate systematically their (chir)optical properties, self-assembly in crystals or at interfaces, charge/spin transport properties and on-surface reactivity at nanoscale. We are also interested in the general synthetic methodology development and enantioselective catalysis. Our ultimate goal is to develop smartmolecular devices.
ING. DANA HOCKOVÁ, CSC. Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganická THEORETICAL BIOINORGANIC CHEMISTRY By correlating experimental and theoretical data, the reaction mechanisms of bioinorganic systems can be elucidated. This not only sheds light on the physicochemical principles (laws) governing the chemical behaviour of bioinorganic systems, but also provides aninsight into
EXOCENTRUS STIERLINI Exocentrus stierlini is ecologically associated with willows ( Salix spp.). Beetles fly from June through August. They infest thin shoots 0.6-2.2 cm diameter of viable and decaying willow trees. Larvae hatching from eggs bore into wood, leaving small inlet on surface, and plug it with fine frass. ANOPLODERA SEXGUTTATA Life cycle: 2 - 3 years. Adults in: May - July. Host plant: polyphagous in deciduous trees ( Quercus, Carpinus, Fagus, Alnus etc.) Distribution: Europe, North Africa, Caucasus. The depicted living beetles were collected on flowers (Apiaceae) in Jena (Thuringia, Germany) and Prague - Zbraslav (Central Bohemia, Czech Republic).LEPTUROBOSCA VIRENS
Adults in: June - August. Host plant: polyphagous in coniferous and deciduous trees ( Picea, Pinus, Abies, Betula) Distribution: mountains of Europe and Russia. The depicted beetles were collected on flowers (Apiaceae) in Tichá Dolina (West High Tatra Mts., North Slovakia). Collected by M.Hoskovec. Subfamilia: Lepturinae Latreille, 1802.ROPALOPUS FEMORATUS
Ropalopus femoratus only occurs in Europe. Locally it is quite frequent. It develops in dry thin twigs of various deciduous trees and shrubs. Very frequently in our climate it attacks dead or dying twigs of Corylus avellana and Quercus spp. Larvae feed subcortically creating broad galleries and later they build a shallow pupal cell in the sapwood. Life-cycle 2 years, adults occur from the end ACANTHOCINUS GRISEUS Acanthocinus griseus is widespread species of coniferous, mainly spruce forests of all categories. Larval development under bark of weakened, uprooted, freshly felled or even standing trees with fresh phloem. Data on the development of larvae in completely dry wood is not based on reality, the wood must contain at least a littlemoisture.
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE CASABOUT USRESEARCHSTUDY & CAREERNEWSEVENTSTECH TRANSFERORGANIC CHEMISTRY VS BIOCHEMISTRYCHEMISTRY VS BIOCHEMISTRYCHEMISTRY VS ORGANIC CHEMISTRY Institute of Organic Chemistry. and Biochemistry of the CAS. Partnership with Alzheon to develop first Alzheimer’s diagnostic assay for measuring neurotoxic. 6 May 2021. IOCB Prague entered into a collaboration and license agreement with Alzheon, Inc., a clinical-stage biopharmaceutical company focused on developing newmedicines for
ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV ČR V březnu představili vědci ze Skupiny Jana Konvalinky při Ústavu organické chemie a biochemie AV ČR novou metodu pro rychlou a snadnou analýzu antigenních testů na SARS-CoV-2, v. Ústav organické chemie a biochemie AV ČR přijímá přihlášky na pozici vedoucí/ho juniorské skupiny v oboru organické chemie s důrazem na LIST OF PHD PROJECTS IN 2021 Modified DNAzymes and DNA origami (Michal Hocek Group) New heterocyclic inhibitors of selected protein kinases (Michal Hocek Group) New deazapurine nucleosides and nucleotides as potential antivirals or cytostatics (Michal Hocek Group) Design and synthesis of novel photoswitches derived from heteroarylazobenzenes and bis-azobenzenes (Zlatko HISTORY - IOCB PRAGUE The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague. REMEMBERING JOHN C. MARTIN Remembering John C. Martin. On 30 March 2021, John C. Martin, former executive chairman and CEO of Gilead Sciences, has passed away. Dr. Martin was one of the key figures without whom some of the most important antivirals used to combat HIV or HBV, originating in Antonín Holý’s lab at IOCB Prague, would never exist.RESEARCH GROUPS
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
LONGHORN BEETLES (CERAMBYCIDAE, COLEOPTERA) OF THE WEST regularly updated encyclopedia containing information about more than 1010 West Palaearctic & former USSR Cerambycidoea taxa; the web site, completely recoded and reshaped during spring 2016, is on-line continuously from 1997 on the same URLTOMÁŠ PLUSKAL
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
PAVLÍNA MALOY ŘEZÁČOVÁ Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganickáPHYMATODES LIVIDUS
April - July. Host plant: polyphagous in deciduous trees ( Quercus, Castanea, Fagus etc.) Distribution: SW/SE Europe, Asia Minor, North Africa, Caucasus. The mounted beetle was beaten from oaks (Quercus) in Erdemli (S Turkey). The living one was collected in Sussargues (Hérault, France). Collected by our friends Petr Moravec andJean-Yves Rasplus.
INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE CASABOUT USRESEARCHSTUDY & CAREERNEWSEVENTSTECH TRANSFERORGANIC CHEMISTRY VS BIOCHEMISTRYCHEMISTRY VS BIOCHEMISTRYCHEMISTRY VS ORGANIC CHEMISTRY Institute of Organic Chemistry. and Biochemistry of the CAS. Partnership with Alzheon to develop first Alzheimer’s diagnostic assay for measuring neurotoxic. 6 May 2021. IOCB Prague entered into a collaboration and license agreement with Alzheon, Inc., a clinical-stage biopharmaceutical company focused on developing newmedicines for
ÚSTAV ORGANICKÉ CHEMIE A BIOCHEMIE AV ČR V březnu představili vědci ze Skupiny Jana Konvalinky při Ústavu organické chemie a biochemie AV ČR novou metodu pro rychlou a snadnou analýzu antigenních testů na SARS-CoV-2, v. Ústav organické chemie a biochemie AV ČR přijímá přihlášky na pozici vedoucí/ho juniorské skupiny v oboru organické chemie s důrazem na LIST OF PHD PROJECTS IN 2021 Modified DNAzymes and DNA origami (Michal Hocek Group) New heterocyclic inhibitors of selected protein kinases (Michal Hocek Group) New deazapurine nucleosides and nucleotides as potential antivirals or cytostatics (Michal Hocek Group) Design and synthesis of novel photoswitches derived from heteroarylazobenzenes and bis-azobenzenes (Zlatko HISTORY - IOCB PRAGUE The CCCC was an international scientific journal founded in 1929 by Emil Votoček (1872–1950) and Jaroslav Heyrovský (1890–1967) and published by IOCB. Since 2012, this peer-reviewed journal has been published under the name ChemPlusChem by Wiley-VCH. The digital archive, which covers the years 1929 to 2011, is owned by IOCB Prague. REMEMBERING JOHN C. MARTIN Remembering John C. Martin. On 30 March 2021, John C. Martin, former executive chairman and CEO of Gilead Sciences, has passed away. Dr. Martin was one of the key figures without whom some of the most important antivirals used to combat HIV or HBV, originating in Antonín Holý’s lab at IOCB Prague, would never exist.RESEARCH GROUPS
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
LONGHORN BEETLES (CERAMBYCIDAE, COLEOPTERA) OF THE WEST regularly updated encyclopedia containing information about more than 1010 West Palaearctic & former USSR Cerambycidoea taxa; the web site, completely recoded and reshaped during spring 2016, is on-line continuously from 1997 on the same URLTOMÁŠ PLUSKAL
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
PAVLÍNA MALOY ŘEZÁČOVÁ Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganickáPHYMATODES LIVIDUS
April - July. Host plant: polyphagous in deciduous trees ( Quercus, Castanea, Fagus etc.) Distribution: SW/SE Europe, Asia Minor, North Africa, Caucasus. The mounted beetle was beaten from oaks (Quercus) in Erdemli (S Turkey). The living one was collected in Sussargues (Hérault, France). Collected by our friends Petr Moravec andJean-Yves Rasplus.
LIST OF PHD PROJECTS IN 2021 Development of capturing techniques for dinucleoside polyphosphate capped RNA (Hana Cahová Group) New CART (cocaine- and amphetamine-regulated transcript) peptide analogs: characterization and effects in models of obesity and neurodegeneration (LenkaMaletínská Group)
LEADERSHIP & STRUCTURE Leadership. Official bodies of IOCB are the Board of the institute, which serves as an advisory authority to the Director and decides on essential scientific issues, the Supervisory board monitoring financial and legal matters and the director, who acts as a statutory body on behalf of the institute. Management. IOCB Board. SupervisoryBoard.
SSP 2021 – AVAILABLE PROJECTS Project: Structure Determination of Newly Described Trypanosoma Surface Receptor. African trypanosomes, the causative agents of sleeping sickness, have developed elaborate mechanisms to avoid clearance by the human immune system.RESEARCH GROUPS
The Institute carries out fundamental research in organic chemistry, biochemistry and related disciplines, focusing in particular on medical and environmental applications. It educates graduate students. It is the seat of the Committee for defence of doctor of sciencedissertations in
KONTAKT - IOCB PRAGUETRANSLATE THIS PAGE Náplní práce ústavu je základní výzkum v oblastech organické chemie, biochemie a příbuzných disciplínách, převážně orientovaný k aplikacím v lékařství a životním prostředí. Ústav se podílí na vzdělávání na universitní úrovni, vedení diplomových a doktorských prací a je sídlem komise pro obhajoby doktorských disertací v oboru organická a bioorganická JUNIOR GROUP LEADER POSITION IN ORGANIC SYNTHESIS Job description. IOCB Prague invites applications for a Junior Group Leader position in synthetic organic chemistry with a strong emphasis on synthetic approaches to complex target molecules at the interface of chemistry and biology. This tenure-track position is comparable to assistant professor at a US university, or to a new investigator HP 6890 GAS CHROMATOGRAPH (HEWLETT PACKARD) One of two small one-channel benchtop Hewlett Packard HP 6850 gas-chromatographs, equipped by FID detector, split/splitless inlet, automatic injector and chiral column, is used for chiral analyses of volatile organic compounds and their mixtures (R. Hanus Group). The second one, with a standard column, is used for routine GC analyses of synthtetic products (U. Jahn Group).MARTIN JINEK
These studies have established a structural framework for engineering novel Cas9 variants with altered PAM specificities. More recently, we have focused on Cas12a (Cpf1), another RNA-guided nuclease enzyme that has emerged as a complementary genome editing tool to Cas9. BIOCHEMISTRY OF PLANT SPECIALIZED METABOLITES During millions of years of evolution, land plants have created an astonishing variety of bioactive specialized metabolites (also referred to as ‘secondary metabolites’ or ‘natural products’) to support their defense and ecological adaptation. Such molecules represent an important source of chemical scaffolds for thedevelopment of new
ISOTOMUS SPECIOSUS JARMILAE Subfamilia: Cerambycinae Latreille, 1802: Tribus: Clytini Mulsant, 1839: Genus: Isotomus Mulsant, 1863 : Species: Isotomus speciosus (Schneider, 1787): Subspecies ${main} ${second} ${date}●
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INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE CASResearch groups
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Tandem processes for the synthesis of carbocycles21 April 2020
Michal Šimek and Ullrich Jahn show in their _Angewandte Chemie_ paper how to rapidly construct functionalized carbocycles in atom economic steps enabled by a clever merger of…Continue reading
Coronavirus: New RNA isolation kits from IOCB Prague2 April 2020
Researchers from Jan Konvalinka Group at IOCB Prague, in extensive collaboration with scientists from RCPTM, IMIC CAS, UCT Prague, IMG CAS, IEB CAS, BIOCEV, CEITEC, and clinical…Continue reading
Call for applications: Junior Group Leader position in organicsynthesis
11 March 2020
IOCB Prague invites applications for a Junior Group Leader position in synthetic organic chemistry with a strong emphasis on synthetic approaches to complex target molecules at…Continue reading
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Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes andAndrostenes
J. V. Bukanova
E. I. Solntseva E. Kudová _Frontiers in Molecular Neuroscience_ 13 : 44 (2020). The ability of androstane and androstene neurosteroids with modifications at C-17, C-5, and C-3 (compounds 1-9) to influence the functional activity of inhibitory glycine and γ-aminobutyric acid (GABA) receptors was estimated. The glycine- and GABA-induced chloride current (_I_Gly and _I_GABA) were measured in isolated pyramidal neurons of the rat hippocampus and isolated rat cerebellar Purkinje cells, correspondingly, using the patch-clamp technique. Our results demonstrate that all the nine neurosteroids display similar biological activity, namely, they strongly inhibited _I_Gly and weakly inhibited _I_GABA. The threshold concentration of neurosteroids inducing effects on _I_Gly was 0.1 μM, and for effects on _I_GABA was 10–50 μM. Moreover, our compounds accelerated desensitization of the _I_Gly with the IC50 values varying from 0.12 to 0.49 μM and decreased the peak amplitude with IC50 values varying from 16 to 22 μM. Interestingly, our study revealed that only compounds 4 (epiandrosterone) and 8 (dehydroepiandrosterone) were able to cause a significant change in _I_GABA in 10 μM concentration. Moreover, compounds 3 (testosterone), 5 (epitestosterone), 6 (dihydroandrostenedione), and 9 (etiocholanedione) did not modulate _I_GABA up to the concentration of 50 μM. Thus, we conclude that compounds 3, 5, 6, and 9 may be identified as selective modulators of _I_Gly. Our results offer new avenues of investigation in the field of drug-like selective modulators of _I_Gly. Go to the publication The bio-chemically selective interaction of hydrogenated and oxidized ultra-small nanodiamonds with proteins and cells I. Machová M. HubálekT. Belinová
A. Fučíková
Š. Stehlík
Š. Stehlík
B. Rezek
M. H. Kalbáčová
_Carbon_ 162 : 650-661 (2020). Go to the publication Membrane Protein Dimerization in Cell-Derived Lipid Membranes Measured by FRET with MC Simulations J. Škerle J. HumpolíčkováN. Johnson
P. Rampírová
E. Poláchová
M. Fliegl
J. Dohnálek
A. Suchánková
D. Jakubec
K. Stříšovský
+ 2 more
_Biophysical Journal_ 118 (8): 1861-1875 (2020). Go to the publication Molecular recognition of fibroblast activation protein for diagnostic and therapeutic applicationsA. Šimková
P. Bušek
A. Šedo J. Konvalinka _Biochimica et Biophysica Acta - Proteins and Proteomics_ 1868 (7):Early View (2020).
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