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Life Sciences
SARS-COV-2: EXPERIMENTAL ANTIVIRAL THERAPY COULD REDUCE An international team of scientists has developed an experimental direct-acting antiviral therapy to treat COVID-19. The antiviral approach used gene-silencing RNA technology known as siRNA (small-interfering RNA) to attack SARS-CoV-2's genome. THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Examining Risk–Benefit Profiles for Vaccines . Article. In this article, David Elder, explores the risk–benefit profiles for various COVID-19 vaccines and discusses the steps taken by regulatory agencies in response to the occurrence of rare blood clotting events associated with the Oxford–AstraZeneca vaccine. PAN-CORONAVIRUS VACCINE BLOCKS SARS-COV-2 AND VARIANTS IN A potential new vaccine developed by members of the Duke Human Vaccine Institute has proven effective in protecting monkeys and mice from a variety of coronavirus infections -- including SARS-CoV-2 as well as the original SARS-CoV-1 and related bat coronaviruses that could potentially cause the next pandemic. INDIVIDUALS TAKING METHOTREXATE RESPOND LESS WELL TO COVID In a review of 200 patients with a wide spectrum of cancer diagnoses, researchers at Montefiore Health System and Albert Einstein College of Medicine in the Bronx, NY, found that after full vaccination, 94% of patients overall demonstrated seroconversion, CLINICAL TRIAL OF UNIVERSAL FLU VACCINE LAUNCHED BY THE A first-in-human, Phase 1 trial assessing the safety and immunogenicity of an investigational nanoparticle influenza vaccine designed to provide long-lasting protection against multiple flu virus strains has begun at the National Institutes of Health Clinical Center in Bethesda, Maryland. THE ANTIBODY TEST THAT QUANTIFIES COVID-19 VACCINE The Antibody Test That Quantifies COVID-19 Vaccine Protection . Industry Insight May 25, 2021 | Dr Stephen Russell, MD, PhD, ImanisLife Sciences
SARS-COV-2: EXPERIMENTAL ANTIVIRAL THERAPY COULD REDUCE An international team of scientists has developed an experimental direct-acting antiviral therapy to treat COVID-19. The antiviral approach used gene-silencing RNA technology known as siRNA (small-interfering RNA) to attack SARS-CoV-2's genome. THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Examining Risk–Benefit Profiles for Vaccines . Article. In this article, David Elder, explores the risk–benefit profiles for various COVID-19 vaccines and discusses the steps taken by regulatory agencies in response to the occurrence of rare blood clotting events associated with the Oxford–AstraZeneca vaccine. PAN-CORONAVIRUS VACCINE BLOCKS SARS-COV-2 AND VARIANTS IN A potential new vaccine developed by members of the Duke Human Vaccine Institute has proven effective in protecting monkeys and mice from a variety of coronavirus infections -- including SARS-CoV-2 as well as the original SARS-CoV-1 and related bat coronaviruses that could potentially cause the next pandemic. CELL SCIENCE ARTICLES Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research,videos and posters.
DRONES HELP WASTE TREATMENT PLANTS GET TO GRIPS WITH BAD The bad odors produced by the Waste Water Treatment Plants, known as WWTPs, have become a growing concern in the cities and towns that host these facilities and are considered by citizens to be the main cause of the perception of pollution, along with the dust and noise. APPLIED SCIENCES VIDEOS Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research,videos and posters.
CLINICAL TRIAL OF UNIVERSAL FLU VACCINE LAUNCHED BY THE A first-in-human, Phase 1 trial assessing the safety and immunogenicity of an investigational nanoparticle influenza vaccine designed to provide long-lasting protection against multiple flu virus strains has begun at the National Institutes of Health Clinical Center in Bethesda, Maryland. CELL SCIENCE ARTICLES Phenotypic Screening in Drug Discovery Article. There is an ever-growing curiosity in the potential benefit of combining phenotypic and genomic data, in the quest to advance small-moleculedrug discovery.
WHAT IS CFDNA?
The advancement of liquid biopsies in the clinic have made these processes invaluable in the search for disease biomarkers in a minimally invasive manner. While a wide variety of biomolecules can be isolated from bodily fluids, free-floating nucleic acids are particularly useful when it comes to the detection of clinically relevant biomarkers in blood. In this article, we will define what BACTERIA HIJACK PHAGE OF COMPETITORS TO DEFEAT THEM Bacteria Hijack Phage of Competitors To Defeat Them. News Jun 11, 2021 . Original story from the University of Vienna. As virus particles,phages
MOLECULE CRITICAL TO BRAIN REJUVENATION IDENTIFIED Recent studies suggest that new brain cells are being formed every day in response to injury, physical exercise, and mental stimulation. Glial cells, and in particular the ones called oligodendrocyte progenitors, are highly responsive to external signals and injuries. TYPES OF ION DETECTOR FOR MASS SPECTROMETRY A key element to all mass spectrometry (MS) systems is the type of detector used to convert a current of mass separated ions into measurable signal. Different types of detectors are used depending upon factors including dynamic range, spatial information retention, noise and suitability to the mass analyzer. In this article, we consider some of the commonly used detectors. DRUG DISCOVERY SCIENCE VIDEOS An Overview of Non CYP Mediated Metabolism Pathways and In Vitro Evaluation Strategies Video Although cytochrome P450 (CYP)-mediated metabolism continues to be of major importance for a large proportion of small molecule new drug candidates, various methods in recent decades have accelerated the development of drug candidates with significant non CYP-mediated metabolism. INDIVIDUALS TAKING METHOTREXATE RESPOND LESS WELL TO COVID Methotrexate Users Respond Less Well to COVID-19 Vaccine. One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows. Published (online May 25) recently in Annals of the Rheumatic Diseases THE ANTIBODY TEST THAT QUANTIFIES COVID-19 VACCINE The key determinant of protection. Neutralizing antibodies are the key determinants of protection from future infection and, for the first time, well-validated high-throughput virus-based assays for COVID-19 can accurately quantify the titers of neutralizing antibodies in individuals. The neutralization assay is a simple blood test, so it is MODERNA’S COVID-19 VACCINE IS SAFE AND EFFECTIVE IN TeenCOVE is the second clinical trial that has explored the safety and efficacy of mRNA-based COVID-19 vaccines in younger populations. Earlier in March, Pfizer–BioNTech announced that in a study of BNT162b2 in 12–15-year-olds, vaccine efficacy was calculated at 100%. Speaking of the latest results shared by Moderna, Russell Viner ANALYTICAL TESTING IN WINE MAKING: TRANSFORM QUALITY Time is of the essence when creating premium wines. Wineries have, therefore, relocated several aspects of quality control to onsite laboratories (Figure 1) and established in-process analytical testing strategies that transform quality control into quality design. With direct access to data on critical biochemical parameters of production DELAYING SECOND DOSE OF PFIZER COVID-19 VACCINE INCREASES A new pre-print study suggests that extending the dose interval of the second Pfizer–BioNTech COVID-19 vaccine (BNT162b2) by twelve weeks significantly increases the immune response in individuals aged 80 or over.. An emergency situation The Pfizer–BioNTech COVID-19 vaccine is an mRNA-based vaccine that received emergency use authorization in the UK in December 2020. SARS-COV-2: EXPERIMENTAL ANTIVIRAL THERAPY COULD REDUCE An international team of scientists has developed an experimental direct-acting antiviral therapy to treat COVID-19. The antiviral approach used gene-silencing RNA technology known as siRNA (small-interfering RNA) to attack SARS-CoV-2's genome. THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Vaccine passports also have the potential to prevent harms caused by lockdowns which, up to recently, were a required public health intervention against the COVID-19 pandemic. However, to ensure that health inequalities, on a national and international level, are not exacerbated, there are practical and ethical challenges that must beaddressed
FUNGI AND BACTERIA CAN ACTIVATE GENES LINKED TO HEAD AND An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance. GUT MICROBE GENES LINKED TO AN ARRAY OF HUMAN DISEASES The findings, to be published May 18 in Nature Communications, link sets of bacterial genes to the presence of coronary artery disease, cirrhosis of the liver, inflammatory bowel disease, colon cancer, and type 2 diabetes. The analysis indicates that three of these conditions--coronary artery disease, inflammatory bowel disease, andliver
EFFICIENTLY DETECTING RARE MUTATIONS IN BLOOD SAMPLES A small portion of cancer cells shed their DNA into the bloodstream, allowing their mutations to be detected via blood sample. Detecting such mutations in blood rather through surgical biopsy of a cancerous tissue is called “a liquid biopsy.”. Such blood-based tests have the potential to detect cancer at an earlier stage, when it can be put INDIVIDUALS TAKING METHOTREXATE RESPOND LESS WELL TO COVID Methotrexate Users Respond Less Well to COVID-19 Vaccine. One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows. Published (online May 25) recently in Annals of the Rheumatic Diseases THE ANTIBODY TEST THAT QUANTIFIES COVID-19 VACCINE The key determinant of protection. Neutralizing antibodies are the key determinants of protection from future infection and, for the first time, well-validated high-throughput virus-based assays for COVID-19 can accurately quantify the titers of neutralizing antibodies in individuals. The neutralization assay is a simple blood test, so it is MODERNA’S COVID-19 VACCINE IS SAFE AND EFFECTIVE IN TeenCOVE is the second clinical trial that has explored the safety and efficacy of mRNA-based COVID-19 vaccines in younger populations. Earlier in March, Pfizer–BioNTech announced that in a study of BNT162b2 in 12–15-year-olds, vaccine efficacy was calculated at 100%. Speaking of the latest results shared by Moderna, Russell Viner ANALYTICAL TESTING IN WINE MAKING: TRANSFORM QUALITY Time is of the essence when creating premium wines. Wineries have, therefore, relocated several aspects of quality control to onsite laboratories (Figure 1) and established in-process analytical testing strategies that transform quality control into quality design. With direct access to data on critical biochemical parameters of production DELAYING SECOND DOSE OF PFIZER COVID-19 VACCINE INCREASES A new pre-print study suggests that extending the dose interval of the second Pfizer–BioNTech COVID-19 vaccine (BNT162b2) by twelve weeks significantly increases the immune response in individuals aged 80 or over.. An emergency situation The Pfizer–BioNTech COVID-19 vaccine is an mRNA-based vaccine that received emergency use authorization in the UK in December 2020. SARS-COV-2: EXPERIMENTAL ANTIVIRAL THERAPY COULD REDUCE An international team of scientists has developed an experimental direct-acting antiviral therapy to treat COVID-19. The antiviral approach used gene-silencing RNA technology known as siRNA (small-interfering RNA) to attack SARS-CoV-2's genome. THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Vaccine passports also have the potential to prevent harms caused by lockdowns which, up to recently, were a required public health intervention against the COVID-19 pandemic. However, to ensure that health inequalities, on a national and international level, are not exacerbated, there are practical and ethical challenges that must beaddressed
FUNGI AND BACTERIA CAN ACTIVATE GENES LINKED TO HEAD AND An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance. GUT MICROBE GENES LINKED TO AN ARRAY OF HUMAN DISEASES The findings, to be published May 18 in Nature Communications, link sets of bacterial genes to the presence of coronary artery disease, cirrhosis of the liver, inflammatory bowel disease, colon cancer, and type 2 diabetes. The analysis indicates that three of these conditions--coronary artery disease, inflammatory bowel disease, andliver
EFFICIENTLY DETECTING RARE MUTATIONS IN BLOOD SAMPLES A small portion of cancer cells shed their DNA into the bloodstream, allowing their mutations to be detected via blood sample. Detecting such mutations in blood rather through surgical biopsy of a cancerous tissue is called “a liquid biopsy.”. Such blood-based tests have the potential to detect cancer at an earlier stage, when it can be put TEAM EXPLORES HOW VIRUSES EVOLVE In a directed evolution experiment, a protein shell naturally occurring in bacteria evolved into a protein container that can encapsulate RNA, mimicking a genome packaging mechanism the team previously discovered in viruses. Credit: ETH Zürich/ Stephan Tette Scientists were able to show for the MICROBOTS DESIGNED TO COMBAT MICROPLASTICS Researchers have developed a framework that provides guidance on performing risk assessments to ensure the levels of antimicrobials released into the environment are safe. Researchers from the Hubrecht Institute in Utrecht (The Netherlands) and the Max Planck Institute for Molecular Biomedicine in BACTERIA HIJACK PHAGE OF COMPETITORS TO DEFEAT THEM Bacteria Hijack Phage of Competitors To Defeat Them. News Jun 11, 2021 . Original story from the University of Vienna. As virus particles,phages
MOLECULES WITH ANTISEIZURE EFFECTS DISCOVERED Nina Ottosson, principal research engineer at Linköping University. Credit: Thor Balkhed/ LiU According to a study, people who have a high sensation-seeking personality trait may be more likely to develop an addiction to cocaine THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Vaccine passports also have the potential to prevent harms caused by lockdowns which, up to recently, were a required public health intervention against the COVID-19 pandemic. However, to ensure that health inequalities, on a national and international level, are not exacerbated, there are practical and ethical challenges that must beaddressed
DRONES HELP WASTE TREATMENT PLANTS GET TO GRIPS WITH BAD The bad odors produced by the Waste Water Treatment Plants, known as WWTPs, have become a growing concern in the cities and towns that host these facilities and are considered by citizens to be the main cause of the perception of pollution, along with the dust and noise. NON-INVASIVE VAGUS NERVE STIMULATION CAN FIGHT OFF FATIGUE Humans have devised endless strategies to stave off tiredness in our busy modern world. Be it industrial-strength coffee, energy drinks of unearthly hues or complex sleep routines, everyone has their own go-tos for staying alert. Now, researchers claim, a new fatigue-fighting technique may have emerged in the form of non-invasive electrical brain stimulation. MOLECULE CRITICAL TO BRAIN REJUVENATION IDENTIFIED Recent studies suggest that new brain cells are being formed every day in response to injury, physical exercise, and mental stimulation. Glial cells, and in particular the ones called oligodendrocyte progenitors, are highly responsive to external signals and injuries. WHAT IS DMPK (DRUG METABOLISM AND PHARMACOKINETICS Today, the competitive landscape throughout the drug development process requires research scientists to apply rigorous qualitative and quantitative analyses to bring lead drug candidates to market in the shortest timeframe possible. In this article, we will discuss what is meant by drug metabolism and pharmacokinetics (DMPK) and explore its role in various stages of pharmaceutical GENETIC FORM OF ALS THAT TARGETS CHILDREN IS IDENTIFIED A new study of over 3000 people has shown for the first time that a single biomarker can accurately indicate the presence of underlying neurodegeneration in people with cognitive issues. The US Food and Drug Administration today (June 7) announced the results of their investigation into Biogen’s INDIVIDUALS TAKING METHOTREXATE RESPOND LESS WELL TO COVID Methotrexate Users Respond Less Well to COVID-19 Vaccine. One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows. Published (online May 25) recently in Annals of the Rheumatic Diseases THE ANTIBODY TEST THAT QUANTIFIES COVID-19 VACCINE The key determinant of protection. Neutralizing antibodies are the key determinants of protection from future infection and, for the first time, well-validated high-throughput virus-based assays for COVID-19 can accurately quantify the titers of neutralizing antibodies in individuals. The neutralization assay is a simple blood test, so it is MODERNA’S COVID-19 VACCINE IS SAFE AND EFFECTIVE IN TeenCOVE is the second clinical trial that has explored the safety and efficacy of mRNA-based COVID-19 vaccines in younger populations. Earlier in March, Pfizer–BioNTech announced that in a study of BNT162b2 in 12–15-year-olds, vaccine efficacy was calculated at 100%. Speaking of the latest results shared by Moderna, Russell Viner ANALYTICAL TESTING IN WINE MAKING: TRANSFORM QUALITY Time is of the essence when creating premium wines. Wineries have, therefore, relocated several aspects of quality control to onsite laboratories (Figure 1) and established in-process analytical testing strategies that transform quality control into quality design. With direct access to data on critical biochemical parameters of production DELAYING SECOND DOSE OF PFIZER COVID-19 VACCINE INCREASES A new pre-print study suggests that extending the dose interval of the second Pfizer–BioNTech COVID-19 vaccine (BNT162b2) by twelve weeks significantly increases the immune response in individuals aged 80 or over.. An emergency situation The Pfizer–BioNTech COVID-19 vaccine is an mRNA-based vaccine that received emergency use authorization in the UK in December 2020. SARS-COV-2: EXPERIMENTAL ANTIVIRAL THERAPY COULD REDUCE An international team of scientists has developed an experimental direct-acting antiviral therapy to treat COVID-19. The antiviral approach used gene-silencing RNA technology known as siRNA (small-interfering RNA) to attack SARS-CoV-2's genome. THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Vaccine passports also have the potential to prevent harms caused by lockdowns which, up to recently, were a required public health intervention against the COVID-19 pandemic. However, to ensure that health inequalities, on a national and international level, are not exacerbated, there are practical and ethical challenges that must beaddressed
FUNGI AND BACTERIA CAN ACTIVATE GENES LINKED TO HEAD AND An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance. GUT MICROBE GENES LINKED TO AN ARRAY OF HUMAN DISEASES The findings, to be published May 18 in Nature Communications, link sets of bacterial genes to the presence of coronary artery disease, cirrhosis of the liver, inflammatory bowel disease, colon cancer, and type 2 diabetes. The analysis indicates that three of these conditions--coronary artery disease, inflammatory bowel disease, andliver
EFFICIENTLY DETECTING RARE MUTATIONS IN BLOOD SAMPLES A small portion of cancer cells shed their DNA into the bloodstream, allowing their mutations to be detected via blood sample. Detecting such mutations in blood rather through surgical biopsy of a cancerous tissue is called “a liquid biopsy.”. Such blood-based tests have the potential to detect cancer at an earlier stage, when it can be put INDIVIDUALS TAKING METHOTREXATE RESPOND LESS WELL TO COVID Methotrexate Users Respond Less Well to COVID-19 Vaccine. One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows. Published (online May 25) recently in Annals of the Rheumatic Diseases THE ANTIBODY TEST THAT QUANTIFIES COVID-19 VACCINE The key determinant of protection. Neutralizing antibodies are the key determinants of protection from future infection and, for the first time, well-validated high-throughput virus-based assays for COVID-19 can accurately quantify the titers of neutralizing antibodies in individuals. The neutralization assay is a simple blood test, so it is MODERNA’S COVID-19 VACCINE IS SAFE AND EFFECTIVE IN TeenCOVE is the second clinical trial that has explored the safety and efficacy of mRNA-based COVID-19 vaccines in younger populations. Earlier in March, Pfizer–BioNTech announced that in a study of BNT162b2 in 12–15-year-olds, vaccine efficacy was calculated at 100%. Speaking of the latest results shared by Moderna, Russell Viner ANALYTICAL TESTING IN WINE MAKING: TRANSFORM QUALITY Time is of the essence when creating premium wines. Wineries have, therefore, relocated several aspects of quality control to onsite laboratories (Figure 1) and established in-process analytical testing strategies that transform quality control into quality design. With direct access to data on critical biochemical parameters of production DELAYING SECOND DOSE OF PFIZER COVID-19 VACCINE INCREASES A new pre-print study suggests that extending the dose interval of the second Pfizer–BioNTech COVID-19 vaccine (BNT162b2) by twelve weeks significantly increases the immune response in individuals aged 80 or over.. An emergency situation The Pfizer–BioNTech COVID-19 vaccine is an mRNA-based vaccine that received emergency use authorization in the UK in December 2020. SARS-COV-2: EXPERIMENTAL ANTIVIRAL THERAPY COULD REDUCE An international team of scientists has developed an experimental direct-acting antiviral therapy to treat COVID-19. The antiviral approach used gene-silencing RNA technology known as siRNA (small-interfering RNA) to attack SARS-CoV-2's genome. THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Vaccine passports also have the potential to prevent harms caused by lockdowns which, up to recently, were a required public health intervention against the COVID-19 pandemic. However, to ensure that health inequalities, on a national and international level, are not exacerbated, there are practical and ethical challenges that must beaddressed
FUNGI AND BACTERIA CAN ACTIVATE GENES LINKED TO HEAD AND An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance. GUT MICROBE GENES LINKED TO AN ARRAY OF HUMAN DISEASES The findings, to be published May 18 in Nature Communications, link sets of bacterial genes to the presence of coronary artery disease, cirrhosis of the liver, inflammatory bowel disease, colon cancer, and type 2 diabetes. The analysis indicates that three of these conditions--coronary artery disease, inflammatory bowel disease, andliver
EFFICIENTLY DETECTING RARE MUTATIONS IN BLOOD SAMPLES A small portion of cancer cells shed their DNA into the bloodstream, allowing their mutations to be detected via blood sample. Detecting such mutations in blood rather through surgical biopsy of a cancerous tissue is called “a liquid biopsy.”. Such blood-based tests have the potential to detect cancer at an earlier stage, when it can be put TEAM EXPLORES HOW VIRUSES EVOLVE In a directed evolution experiment, a protein shell naturally occurring in bacteria evolved into a protein container that can encapsulate RNA, mimicking a genome packaging mechanism the team previously discovered in viruses. Credit: ETH Zürich/ Stephan Tette Scientists were able to show for the MICROBOTS DESIGNED TO COMBAT MICROPLASTICS Researchers have developed a framework that provides guidance on performing risk assessments to ensure the levels of antimicrobials released into the environment are safe. Researchers from the Hubrecht Institute in Utrecht (The Netherlands) and the Max Planck Institute for Molecular Biomedicine in BACTERIA HIJACK PHAGE OF COMPETITORS TO DEFEAT THEM Bacteria Hijack Phage of Competitors To Defeat Them. News Jun 11, 2021 . Original story from the University of Vienna. As virus particles,phages
MOLECULES WITH ANTISEIZURE EFFECTS DISCOVERED Nina Ottosson, principal research engineer at Linköping University. Credit: Thor Balkhed/ LiU According to a study, people who have a high sensation-seeking personality trait may be more likely to develop an addiction to cocaine DRONES HELP WASTE TREATMENT PLANTS GET TO GRIPS WITH BAD The bad odors produced by the Waste Water Treatment Plants, known as WWTPs, have become a growing concern in the cities and towns that host these facilities and are considered by citizens to be the main cause of the perception of pollution, along with the dust and noise. THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Vaccine passports also have the potential to prevent harms caused by lockdowns which, up to recently, were a required public health intervention against the COVID-19 pandemic. However, to ensure that health inequalities, on a national and international level, are not exacerbated, there are practical and ethical challenges that must beaddressed
NON-INVASIVE VAGUS NERVE STIMULATION CAN FIGHT OFF FATIGUE Humans have devised endless strategies to stave off tiredness in our busy modern world. Be it industrial-strength coffee, energy drinks of unearthly hues or complex sleep routines, everyone has their own go-tos for staying alert. Now, researchers claim, a new fatigue-fighting technique may have emerged in the form of non-invasive electrical brain stimulation. MOLECULE CRITICAL TO BRAIN REJUVENATION IDENTIFIED Recent studies suggest that new brain cells are being formed every day in response to injury, physical exercise, and mental stimulation. Glial cells, and in particular the ones called oligodendrocyte progenitors, are highly responsive to external signals and injuries.WHAT IS CFDNA?
The advancement of liquid biopsies in the clinic have made these processes invaluable in the search for disease biomarkers in a minimally invasive manner. While a wide variety of biomolecules can be isolated from bodily fluids, free-floating nucleic acids are particularly useful when it comes to the detection of clinically relevant biomarkers in blood. In this article, we will define what GENETIC FORM OF ALS THAT TARGETS CHILDREN IS IDENTIFIED A new study of over 3000 people has shown for the first time that a single biomarker can accurately indicate the presence of underlying neurodegeneration in people with cognitive issues. The US Food and Drug Administration today (June 7) announced the results of their investigation into Biogen’s INDIVIDUALS TAKING METHOTREXATE RESPOND LESS WELL TO COVID Methotrexate Users Respond Less Well to COVID-19 Vaccine. One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows. Published (online May 25) recently in Annals of the Rheumatic Diseases CLINICAL TRIAL OF UNIVERSAL FLU VACCINE LAUNCHED BY THE Clinical Trial of Universal Flu Vaccine Launched by the NIH. Credit: CDC on Unsplash. A first-in-human, Phase 1 trial assessing the safety and immunogenicity of an investigational nanoparticle influenza vaccine designed to provide long-lasting protection against multiple flu virus strains has begun at the National Institutes of HealthClinical
THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Vaccine passports also have the potential to prevent harms caused by lockdowns which, up to recently, were a required public health intervention against the COVID-19 pandemic. However, to ensure that health inequalities, on a national and international level, are not exacerbated, there are practical and ethical challenges that must beaddressed
SARS-COV-2: EXPERIMENTAL ANTIVIRAL THERAPY COULD REDUCE An international team of scientists has developed an experimental direct-acting antiviral therapy to treat COVID-19. The antiviral approach used gene-silencing RNA technology known as siRNA (small-interfering RNA) to attack SARS-CoV-2's genome. FUNGI AND BACTERIA CAN ACTIVATE GENES LINKED TO HEAD AND An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance. PAN-CORONAVIRUS VACCINE BLOCKS SARS-COV-2 AND VARIANTS IN We think that's why this vaccine is effective against SARS-CoV-1, SARS-CoV-2 and at least four of its common variants, plus additional animal coronaviruses." "There have been three coronavirus epidemics in the past 20 years, so there is a need to develop effective vaccines that can target these pathogens prior to the next pandemic," Haynessaid.
GUT MICROBE GENES LINKED TO AN ARRAY OF HUMAN DISEASES The findings, to be published May 18 in Nature Communications, link sets of bacterial genes to the presence of coronary artery disease, cirrhosis of the liver, inflammatory bowel disease, colon cancer, and type 2 diabetes. The analysis indicates that three of these conditions--coronary artery disease, inflammatory bowel disease, andliver
HOW SCIENCE IS HELPING TO SOLVE THE FOOD WASTE CRISIS A few pounds of damaged fruit here, a couple of uneaten sides left behind at a restaurant there. It may not seem like much, but it adds up. In fact, it amounts to nearly one billion tons of wasted food per year globally according to the United Nations Environment Program. The situation is particularly dire in the United States, where food waste comprises 22% of municipal solid waste —the TYPES OF ION DETECTOR FOR MASS SPECTROMETRY IMPROVING OUR UNDERSTANDING OF THE LINK BETWEEN INDOOR AND People spend about 80-90% of their time indoors. Compared to outdoor air quality, indoor air quality is more relevant to people's health. Therefore, understanding the levels, sources and evolution of particulate matter (PM) indoors is important for the accurate evaluation of people's health risks to aerosol exposure. INDIVIDUALS TAKING METHOTREXATE RESPOND LESS WELL TO COVID Methotrexate Users Respond Less Well to COVID-19 Vaccine. One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows. Published (online May 25) recently in Annals of the Rheumatic Diseases CLINICAL TRIAL OF UNIVERSAL FLU VACCINE LAUNCHED BY THE Clinical Trial of Universal Flu Vaccine Launched by the NIH. Credit: CDC on Unsplash. A first-in-human, Phase 1 trial assessing the safety and immunogenicity of an investigational nanoparticle influenza vaccine designed to provide long-lasting protection against multiple flu virus strains has begun at the National Institutes of HealthClinical
THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Vaccine passports also have the potential to prevent harms caused by lockdowns which, up to recently, were a required public health intervention against the COVID-19 pandemic. However, to ensure that health inequalities, on a national and international level, are not exacerbated, there are practical and ethical challenges that must beaddressed
SARS-COV-2: EXPERIMENTAL ANTIVIRAL THERAPY COULD REDUCE An international team of scientists has developed an experimental direct-acting antiviral therapy to treat COVID-19. The antiviral approach used gene-silencing RNA technology known as siRNA (small-interfering RNA) to attack SARS-CoV-2's genome. FUNGI AND BACTERIA CAN ACTIVATE GENES LINKED TO HEAD AND An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance. PAN-CORONAVIRUS VACCINE BLOCKS SARS-COV-2 AND VARIANTS IN We think that's why this vaccine is effective against SARS-CoV-1, SARS-CoV-2 and at least four of its common variants, plus additional animal coronaviruses." "There have been three coronavirus epidemics in the past 20 years, so there is a need to develop effective vaccines that can target these pathogens prior to the next pandemic," Haynessaid.
GUT MICROBE GENES LINKED TO AN ARRAY OF HUMAN DISEASES The findings, to be published May 18 in Nature Communications, link sets of bacterial genes to the presence of coronary artery disease, cirrhosis of the liver, inflammatory bowel disease, colon cancer, and type 2 diabetes. The analysis indicates that three of these conditions--coronary artery disease, inflammatory bowel disease, andliver
HOW SCIENCE IS HELPING TO SOLVE THE FOOD WASTE CRISIS A few pounds of damaged fruit here, a couple of uneaten sides left behind at a restaurant there. It may not seem like much, but it adds up. In fact, it amounts to nearly one billion tons of wasted food per year globally according to the United Nations Environment Program. The situation is particularly dire in the United States, where food waste comprises 22% of municipal solid waste —the TYPES OF ION DETECTOR FOR MASS SPECTROMETRY IMPROVING OUR UNDERSTANDING OF THE LINK BETWEEN INDOOR AND People spend about 80-90% of their time indoors. Compared to outdoor air quality, indoor air quality is more relevant to people's health. Therefore, understanding the levels, sources and evolution of particulate matter (PM) indoors is important for the accurate evaluation of people's health risks to aerosol exposure. MOLECULES WITH ANTISEIZURE EFFECTS DISCOVERED Nina Ottosson, principal research engineer at Linköping University. Credit: Thor Balkhed/ LiU A study will investigate whether it's possible to predict who remains susceptible to SARS-CoV-2 variants after having COVID-19 or receiving a COVID-19-specific vaccine THERAPEUTIC POTENTIAL OF MESENCHYMAL STROMAL CELLS BOOSTED Gel-coated (red) mesenchymal stromal cells (yellow) can degrade collagen (green) over a distance in the presence of tumor necrosis factor-alpha. Credit: Jae-Won Shin and Sing-Wan Wong/UIC Researchers have shown that a non-toxic complex of manganese makes it MOLECULAR MECHANISM OF IMMUNE CELL MIGRATION REVEALED (Left panel) Flow chart demonstrating dendritic cells (DCs) in wildtype (WT) and DC-specific Lamtor1-KO mice. In the absence of Lamtor1, skin-draining lymph nodes showed reduced numbers of migratory DCs. (Right panel) Representative images of the NEW STRATEGY FOR SELECTIVELY LABELING PEPTIDES Activation of a C-H bond at the end of the process of synthesis enables the fluorescent labelling of peptides and lipopeptides giving it properties that glow different colours. Credit: Nikolaos Kaplaneris/ University of Göttingen New research provides PRECISION SL HYDROGEN GENERATOR VIDEO Peak Scientific's Precision SL is the smallest hydrogen generator for GC-FID. The Precision SL line has been designed to offer a streamlined laboratory-grade hydrogen gas solution for GC flame detectors at a purity of 99.9995%, available in both 100 and 200cc/min. Precision issafe, simple to
UK’S PREFERENCE FOR ASTRAZENECA COVID-19 VACCINE HAS A new report by researchers including the University of Bristol and King's College London has found that the UK public's preference for the AstraZeneca–Oxford vaccine has declined since March. In March, the AstraZeneca–Oxford COVID-19 vaccine, Vaxzevria – formerly ChAdOx1 – was at the center of several regulatory agencyinvestigations
ACCELERATING DIAGNOSTIC TEST DEVELOPMENT INFOGRAPHIC Many clinical decisions are based on a diagnostic test, highlighting their importance in developing therapies and improving patient outcomes. There are many elements to consider when designing a diagnostic test, assay or kit, how to move from prototype to commercialization time efficiently may be one of the most important. DRUG SENSITIVITY OF LIVER CANCER CELLS Oncotarget published "Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells" which reported that this study aimed to investigate whether Hepatocellular Cancer (HCC) cells cultured in more native conditions have an altered phenotype and drug sensitivity compared to those cultured in standard conditions. STOPPING MATH EDUCATION EARLY IS BAD FOR THE BRAIN 1 day ago · Adolescents who stopped studying maths exhibited greater disadvantage - compared with peers who continued studying maths - in terms of brain and cognitive development, according to a new study published in the Proceedings of the National Academy of Sciences. 133 students between the ages of 14-18 took part in an experiment run by researchers from the Department of Experimental COVID-19 ANTIBODY TESTING: S VS. N PROTEIN Technology Networks spoke to Dr Iswariya Venkataraman, Scientific Affairs Lead at EUROIMMUN US, to learn about the differences between the S and N proteins and what makes them suitable as target antigens in serology testing. Iswariya also discussed the findings and implications from a study which cautioned against the extensive use of tests that detect antibodies against the N protein SARS-COV-2: EXPERIMENTAL ANTIVIRAL THERAPY COULD REDUCE An international team of scientists has developed an experimental direct-acting antiviral therapy to treat COVID-19. The antiviral approach used gene-silencing RNA technology known as siRNA (small-interfering RNA) to attack SARS-CoV-2's genome. INDIVIDUALS TAKING METHOTREXATE RESPOND LESS WELL TO COVID Methotrexate Users Respond Less Well to COVID-19 Vaccine. One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows. Published (online May 25) recently in Annals of the Rheumatic Diseases FUNGI AND BACTERIA CAN ACTIVATE GENES LINKED TO HEAD AND An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance. THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Vaccine passports also have the potential to prevent harms caused by lockdowns which, up to recently, were a required public health intervention against the COVID-19 pandemic. However, to ensure that health inequalities, on a national and international level, are not exacerbated, there are practical and ethical challenges that must beaddressed
PAN-CORONAVIRUS VACCINE BLOCKS SARS-COV-2 AND VARIANTS IN We think that's why this vaccine is effective against SARS-CoV-1, SARS-CoV-2 and at least four of its common variants, plus additional animal coronaviruses." "There have been three coronavirus epidemics in the past 20 years, so there is a need to develop effective vaccines that can target these pathogens prior to the next pandemic," Haynessaid.
CLINICAL TRIAL OF UNIVERSAL FLU VACCINE LAUNCHED BY THE Clinical Trial of Universal Flu Vaccine Launched by the NIH. Credit: CDC on Unsplash. A first-in-human, Phase 1 trial assessing the safety and immunogenicity of an investigational nanoparticle influenza vaccine designed to provide long-lasting protection against multiple flu virus strains has begun at the National Institutes of HealthClinical
IMPROVING OUR UNDERSTANDING OF THE LINK BETWEEN INDOOR AND People spend about 80-90% of their time indoors. Compared to outdoor air quality, indoor air quality is more relevant to people's health. Therefore, understanding the levels, sources and evolution of particulate matter (PM) indoors is important for the accurate evaluation of people's health risks to aerosol exposure. TYPES OF ION DETECTOR FOR MASS SPECTROMETRY HOW SCIENCE IS HELPING TO SOLVE THE FOOD WASTE CRISIS A few pounds of damaged fruit here, a couple of uneaten sides left behind at a restaurant there. It may not seem like much, but it adds up. In fact, it amounts to nearly one billion tons of wasted food per year globally according to the United Nations Environment Program. The situation is particularly dire in the United States, where food waste comprises 22% of municipal solid waste —the GUT MICROBE GENES LINKED TO AN ARRAY OF HUMAN DISEASES The findings, to be published May 18 in Nature Communications, link sets of bacterial genes to the presence of coronary artery disease, cirrhosis of the liver, inflammatory bowel disease, colon cancer, and type 2 diabetes. The analysis indicates that three of these conditions--coronary artery disease, inflammatory bowel disease, andliver
SARS-COV-2: EXPERIMENTAL ANTIVIRAL THERAPY COULD REDUCE An international team of scientists has developed an experimental direct-acting antiviral therapy to treat COVID-19. The antiviral approach used gene-silencing RNA technology known as siRNA (small-interfering RNA) to attack SARS-CoV-2's genome. INDIVIDUALS TAKING METHOTREXATE RESPOND LESS WELL TO COVID Methotrexate Users Respond Less Well to COVID-19 Vaccine. One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows. Published (online May 25) recently in Annals of the Rheumatic Diseases FUNGI AND BACTERIA CAN ACTIVATE GENES LINKED TO HEAD AND An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance. THE ETHICS AND SAFETY OF COVID-19 VACCINE PASSPORTS Vaccine passports also have the potential to prevent harms caused by lockdowns which, up to recently, were a required public health intervention against the COVID-19 pandemic. However, to ensure that health inequalities, on a national and international level, are not exacerbated, there are practical and ethical challenges that must beaddressed
PAN-CORONAVIRUS VACCINE BLOCKS SARS-COV-2 AND VARIANTS IN We think that's why this vaccine is effective against SARS-CoV-1, SARS-CoV-2 and at least four of its common variants, plus additional animal coronaviruses." "There have been three coronavirus epidemics in the past 20 years, so there is a need to develop effective vaccines that can target these pathogens prior to the next pandemic," Haynessaid.
CLINICAL TRIAL OF UNIVERSAL FLU VACCINE LAUNCHED BY THE Clinical Trial of Universal Flu Vaccine Launched by the NIH. Credit: CDC on Unsplash. A first-in-human, Phase 1 trial assessing the safety and immunogenicity of an investigational nanoparticle influenza vaccine designed to provide long-lasting protection against multiple flu virus strains has begun at the National Institutes of HealthClinical
IMPROVING OUR UNDERSTANDING OF THE LINK BETWEEN INDOOR AND People spend about 80-90% of their time indoors. Compared to outdoor air quality, indoor air quality is more relevant to people's health. Therefore, understanding the levels, sources and evolution of particulate matter (PM) indoors is important for the accurate evaluation of people's health risks to aerosol exposure. TYPES OF ION DETECTOR FOR MASS SPECTROMETRY HOW SCIENCE IS HELPING TO SOLVE THE FOOD WASTE CRISIS A few pounds of damaged fruit here, a couple of uneaten sides left behind at a restaurant there. It may not seem like much, but it adds up. In fact, it amounts to nearly one billion tons of wasted food per year globally according to the United Nations Environment Program. The situation is particularly dire in the United States, where food waste comprises 22% of municipal solid waste —the GUT MICROBE GENES LINKED TO AN ARRAY OF HUMAN DISEASES The findings, to be published May 18 in Nature Communications, link sets of bacterial genes to the presence of coronary artery disease, cirrhosis of the liver, inflammatory bowel disease, colon cancer, and type 2 diabetes. The analysis indicates that three of these conditions--coronary artery disease, inflammatory bowel disease, andliver
MOLECULES WITH ANTISEIZURE EFFECTS DISCOVERED Nina Ottosson, principal research engineer at Linköping University. Credit: Thor Balkhed/ LiU A study will investigate whether it's possible to predict who remains susceptible to SARS-CoV-2 variants after having COVID-19 or receiving a COVID-19-specific vaccine THERAPEUTIC POTENTIAL OF MESENCHYMAL STROMAL CELLS BOOSTED Gel-coated (red) mesenchymal stromal cells (yellow) can degrade collagen (green) over a distance in the presence of tumor necrosis factor-alpha. Credit: Jae-Won Shin and Sing-Wan Wong/UIC Researchers have shown that a non-toxic complex of manganese makes it MOLECULAR MECHANISM OF IMMUNE CELL MIGRATION REVEALED (Left panel) Flow chart demonstrating dendritic cells (DCs) in wildtype (WT) and DC-specific Lamtor1-KO mice. In the absence of Lamtor1, skin-draining lymph nodes showed reduced numbers of migratory DCs. (Right panel) Representative images of the NEW STRATEGY FOR SELECTIVELY LABELING PEPTIDES Activation of a C-H bond at the end of the process of synthesis enables the fluorescent labelling of peptides and lipopeptides giving it properties that glow different colours. Credit: Nikolaos Kaplaneris/ University of Göttingen New research provides PRECISION SL HYDROGEN GENERATOR VIDEO Peak Scientific's Precision SL is the smallest hydrogen generator for GC-FID. The Precision SL line has been designed to offer a streamlined laboratory-grade hydrogen gas solution for GC flame detectors at a purity of 99.9995%, available in both 100 and 200cc/min. Precision issafe, simple to
UK’S PREFERENCE FOR ASTRAZENECA COVID-19 VACCINE HAS A new report by researchers including the University of Bristol and King's College London has found that the UK public's preference for the AstraZeneca–Oxford vaccine has declined since March. In March, the AstraZeneca–Oxford COVID-19 vaccine, Vaxzevria – formerly ChAdOx1 – was at the center of several regulatory agencyinvestigations
ACCELERATING DIAGNOSTIC TEST DEVELOPMENT INFOGRAPHIC Many clinical decisions are based on a diagnostic test, highlighting their importance in developing therapies and improving patient outcomes. There are many elements to consider when designing a diagnostic test, assay or kit, how to move from prototype to commercialization time efficiently may be one of the most important. DRUG SENSITIVITY OF LIVER CANCER CELLS Oncotarget published "Effect of cell microenvironment on the drug sensitivity of hepatocellular cancer cells" which reported that this study aimed to investigate whether Hepatocellular Cancer (HCC) cells cultured in more native conditions have an altered phenotype and drug sensitivity compared to those cultured in standard conditions. STOPPING MATH EDUCATION EARLY IS BAD FOR THE BRAIN 1 day ago · Adolescents who stopped studying maths exhibited greater disadvantage - compared with peers who continued studying maths - in terms of brain and cognitive development, according to a new study published in the Proceedings of the National Academy of Sciences. 133 students between the ages of 14-18 took part in an experiment run by researchers from the Department of Experimental COVID-19 ANTIBODY TESTING: S VS. N PROTEIN Technology Networks spoke to Dr Iswariya Venkataraman, Scientific Affairs Lead at EUROIMMUN US, to learn about the differences between the S and N proteins and what makes them suitable as target antigens in serology testing. Iswariya also discussed the findings and implications from a study which cautioned against the extensive use of tests that detect antibodies against the N protein__
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OXFORD'S COVID-19 VACCINE HAS 70% EFFICACY RATENews
There are now over 170 teams of researchers working to develop a vaccine for protection against COVID-19. Over the last few weeks, a number of groups shared interim analysis data on candidates that have reached Phase III clinical testing. The latest addition is the University of Oxford – in collaboration with the pharmaceutical company AstraZeneca – who today announce an efficacy of 70.4% for the candidate, ChAdOx1 nCoV-2019.Read more __
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Colorimetric LAMP opens up opportunities for human health and medical diagnosis that, until recently, have not been possible due to the specialized requirements of traditional PCR. In this article, discover how the technique can be used in applications ranging from COVID-19 diagnosis to studying telomere dynamics while in outer space.Read more __
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