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Read our COVID-19 research and news.FIRST RELEASE
Selected _Science_ papers are published online ahead of print. Some editorial changes may occur between the online version and the final printed version. Read More*
NOVEMBER 19, 2020
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How directed evolution reshapes the energy landscape in an enzyme toboost catalysis
By Renee Otten, Ricardo A. P. Pádua, H. Adrian Bunzel, Vy Nguyen, Warintra Pitsawong, MacKenzie Patterson, Shuo Sui, Sarah L. Perry, Aina E. Cohen, Donald Hilvert, Dorothee Kern Published Online19 Nov 2020 __Full Access__Restricted Access DOI: 10.1126/science.abd3623* Abstract
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Coordination between microbiota and root endodermis supports plant mineral nutrient homeostasis By Isai Salas-González, Guilhem Reyt, Paulina Flis, Valéria Custódio, David Gopaulchan, Niokhor Bakhoum, Tristan P. Dew, Kiran Suresh, Rochus Benni Franke, Jeffery L. Dangl, David E. Salt, GabrielCastrillo
Published Online19 Nov 2020 __Full Access__Restricted Access DOI: 10.1126/science.abd0695* Abstract
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Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth By Ryan S. Roark, Hui Li, Wilton B. Williams, Hema Chug, Rosemarie D. Mason, Jason Gorman, Shuyi Wang, Fang-Hua Lee, Juliette Rando, Mattia Bonsignori, Kwan-Ki Hwang, Kevin O. Saunders, Kevin Wiehe, M. Anthony Moody, Peter T. Hraber, Kshitij Wagh, Elena E. Giorgi, Ronnie M. Russell, Frederic Bibollet-Ruche, Weimin Liu, Jesse Connell, Andrew G. Smith, Julia DeVoto, Alexander I. Murphy, Jessica Smith, Wenge Ding, Chengyan Zhao, Neha Chohan, Maho Okumura, Christina Rosario, Yu Ding, Emily Lindemuth, Anya M. Bauer, Katharine J. Bar, David Ambrozak, Cara W. Chao, Gwo-Yu Chuang, Hui Geng, Bob C. Lin, Mark K. Louder, Richard Nguyen, Baoshan Zhang, Mark G. Lewis, Donald Raymond, Nicole A. Doria-Rose, Chaim A. Schramm, Daniel C. Douek, Mario Roederer, Thomas B. Kepler, Garnett Kelsoe, John R. Mascola, Peter D. Kwong, Bette T. Korber, Stephen C. Harrison, Barton F. Haynes, Beatrice H. Hahn,George M. Shaw
Published Online19 Nov 2020 __Full Access__Restricted Access DOI: 10.1126/science.abd2638* Abstract
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Tailored quinones support high-turnover Pd catalysts for oxidative C–H arylation with O2 By Chase A. Salazar, Kaylin N. Flesch, Brandon E. Haines, Philip S. Zhou, Djamaladdin G. Musaev, Shannon S. Stahl Published Online19 Nov 2020 __Full Access__Restricted Access DOI: 10.1126/science.abd1085* Abstract
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NOVEMBER 17, 2020
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Ensuring vaccine safety By David M. Knipe, Ofer Levy, Katherine A. Fitzgerald, ElkeMühlberger
Published Online17 Nov 2020 __Full Access__Restricted Access DOI: 10.1126/science.abf0357* Abstract
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NOVEMBER 12, 2020
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The ZSWIM8 ubiquitin ligase mediates target-directed microRNAdegradation
By Charlie Y. Shi, Elena R. Kingston, Benjamin Kleaveland, Daniel H. Lin, Michael W. Stubna, David P. Bartel Published Online12 Nov 2020 __Full Access__Restricted Access DOI: 10.1126/science.abc9359* Abstract
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SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo By Yixuan J. Hou, Shiho Chiba, Peter Halfmann, Camille Ehre, Makoto Kuroda, Kenneth H. Dinnon III, Sarah R. Leist, Alexandra Schäfer, Noriko Nakajima, Kenta Takahashi, Rhianna E. Lee, Teresa M. Mascenik, Rachel Graham, Caitlin E. Edwards, Longping V. Tse, Kenichi Okuda, Alena J. Markmann, Luther Bartelt, Aravinda de Silva, David M. Margolis, Richard C. Boucher, Scott H. Randell, Tadaki Suzuki, Lisa E. Gralinski, Yoshihiro Kawaoka, Ralph S. Baric Published Online12 Nov 2020 __Open Access DOI: 10.1126/science.abe8499* Abstract
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Optically addressable molecular spins for quantum informationprocessing
By S. L. Bayliss, D. W. Laorenza, P. J. Mintun, B. D. Kovos, D. E. Freedman, D. D. Awschalom Published Online12 Nov 2020 __Full Access__Restricted Access DOI: 10.1126/science.abb9352* Abstract
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A ubiquitin ligase mediates target-directed microRNA decay independently of tailing and trimming By Jaeil Han, Collette A. LaVigne, Benjamin T. Jones, He Zhang, Frank Gillett, Joshua T. Mendell Published Online12 Nov 2020 __Full Access__Restricted Access DOI: 10.1126/science.abc9546* Abstract
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NOVEMBER 11, 2020
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Seroprevalence of anti–SARS-CoV-2 IgG antibodies in Kenyan blooddonors
By Sophie Uyoga, Ifedayo M. O. Adetifa, Henry K. Karanja, James Nyagwange, James Tuju, Perpetual Wanjiku, Rashid Aman, Mercy Mwangangi, Patrick Amoth, Kadondi Kasera, Wangari Ng’ang’a, Charles Rombo, Christine Yegon, Khamisi Kithi, Elizabeth Odhiambo, Thomas Rotich, Irene Orgut, Sammy Kihara, Mark Otiende, Christian Bottomley, Zonia N. Mupe, Eunice W. Kagucia, Katherine E. Gallagher, Anthony Etyang, Shirine Voller, John N. Gitonga, Daisy Mugo, Charles N. Agoti, Edward Otieno, Leonard Ndwiga, Teresa Lambe, Daniel Wright, Edwine Barasa, Benjamin Tsofa, Philip Bejon, Lynette I. Ochola-Oyier, Ambrose Agweyu, J. Anthony G. Scott, George M. Warimwe Published Online11 Nov 2020 __Open Access DOI: 10.1126/science.abe1916* Abstract
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NOVEMBER 10, 2020
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Transmission of SARS-CoV-2 on mink farms between humans and mink andback to humans
By Bas B. Oude Munnink, Reina S. Sikkema, David F. Nieuwenhuijse, Robert Jan Molenaar, Emmanuelle Munger, Richard Molenkamp, Arco van der Spek, Paulien Tolsma, Ariene Rietveld, Miranda Brouwer, Noortje Bouwmeester-Vincken, Frank Harders, Renate Hakze-van der Honing, Marjolein C. A. Wegdam-Blans, Ruth J. Bouwstra, Corine GeurtsvanKessel, Annemiek A. van der Eijk, Francisca C. Velkers, Lidwien A. M. Smit, Arjan Stegeman, Wim H. M. van der Poel, Marion P.G. Koopmans
Published Online10 Nov 2020 __Open Access DOI: 10.1126/science.abe5901* Abstract
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NOVEMBER 06, 2020
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Preexisting and de novo humoral immunity to SARS-CoV-2 in humans By Kevin W. Ng, Nikhil Faulkner, Georgina H. Cornish, Annachiara Rosa, Ruth Harvey, Saira Hussain, Rachel Ulferts, Christopher Earl, Antoni G. Wrobel, Donald J. Benton, Chloe Roustan, William Bolland, Rachael Thompson, Ana Agua-Doce, Philip Hobson, Judith Heaney, Hannah Rickman, Stavroula Paraskevopoulou, Catherine F. Houlihan, Kirsty Thomson, Emilie Sanchez, Gee Yen Shin, Moira J. Spyer, Dhira Joshi, Nicola O’Reilly, Philip A. Walker, Svend Kjaer, Andrew Riddell, Catherine Moore, Bethany R. Jebson, Meredyth Wilkinson, Lucy R. Marshall, Elizabeth C. Rosser, Anna Radziszewska, Hannah Peckham, Coziana Ciurtin, Lucy R. Wedderburn, Rupert Beale, Charles Swanton, Sonia Gandhi, Brigitta Stockinger, John McCauley, Steve J. Gamblin, Laura E. McCoy, Peter Cherepanov, Eleni Nastouli, George Kassiotis Published Online06 Nov 2020 __Open Access DOI: 10.1126/science.abe1107* Abstract
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NOVEMBER 05, 2020
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Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2 By Yufei Xiang, Sham Nambulli, Zhengyun Xiao, Heng Liu, Zhe Sang, W. Paul Duprex, Dina Schneidman-Duhovny, Cheng Zhang, Yi Shi Published Online05 Nov 2020 __Open Access DOI: 10.1126/science.abe4747* Abstract
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De novo design of potent and resilient hACE2 decoys to neutralizeSARS-CoV-2
By Thomas W. Linsky, Renan Vergara, Nuria Codina, Jorgen W. Nelson, Matthew J. Walker, Wen Su, Christopher O. Barnes, Tien-Ying Hsiang, Katharina Esser-Nobis, Kevin Yu, Z. Beau Reneer, Yixuan J. Hou, Tanu Priya, Masaya Mitsumoto, Avery Pong, Uland Y. Lau, Marsha L. Mason, Jerry Chen, Alex Chen, Tania Berrocal, Hong Peng, Nicole S. Clairmont, Javier Castellanos, Yu-Ru Lin, Anna Josephson-Day, Ralph S. Baric, Deborah H. Fuller, Carl D. Walkey, Ted M. Ross, Ryan Swanson, Pamela J. Bjorkman, Michael Gale Jr., Luis M. Blancas-Mejia, Hui-Ling Yen, Daniel-Adriano Silva Published Online05 Nov 2020 __Open Access DOI: 10.1126/science.abe0075* Abstract
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An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike By Michael Schoof, Bryan Faust, Reuben A. Saunders, Smriti Sangwan, Veronica Rezelj, Nick Hoppe, Morgane Boone, Christian B. Billesbølle, Cristina Puchades, Caleigh M. Azumaya, Huong T. Kratochvil, Marcell Zimanyi, Ishan Deshpande, Jiahao Liang, Sasha Dickinson, Henry C. Nguyen, Cynthia M. Chio, Gregory E. Merz, Michael C. Thompson, Devan Diwanji, Kaitlin Schaefer, Aditya A. Anand, Niv Dobzinski, Beth Shoshana Zha, Camille R. Simoneau, Kristoffer Leon, Kris M. White, Un Seng Chio, Meghna Gupta, Mingliang Jin, Fei Li, Yanxin Liu, Kaihua Zhang, David Bulkley, Ming Sun, Amber M. Smith, Alexandrea N. Rizo, Frank Moss, Axel F. Brilot, Sergei Pourmal, Raphael Trenker, Thomas Pospiech, Sayan Gupta, Benjamin Barsi-Rhyne, Vladislav Belyy, Andrew W. Barile-Hill, Silke Nock, Yuwei Liu, Nevan J. Krogan, Corie Y. Ralston, Danielle L. Swaney, Adolfo García-Sastre, Melanie Ott, Marco Vignuzzi, QCRG Structural Biology Consortium, Peter Walter, AashishManglik
Published Online05 Nov 2020 __Open Access DOI: 10.1126/science.abe3255* Abstract
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Structural basis of antagonizing the vitamin K catalytic cycle foranticoagulation
By Shixuan Liu, Shuang Li, Guomin Shen, Narayanasami Sukumar, Andrzej M. Krezel, Weikai Li Published Online05 Nov 2020 __Full Access__Restricted Access DOI: 10.1126/science.abc5667* Abstract
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OCTOBER 28, 2020
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Robust neutralizing antibodies to SARS-CoV-2 infection persist formonths
By Ania Wajnberg, Fatima Amanat, Adolfo Firpo, Deena R. Altman, Mark J. Bailey, Mayce Mansour, Meagan McMahon, Philip Meade, Damodara Rao Mendu, Kimberly Muellers, Daniel Stadlbauer, Kimberly Stone, Shirin Strohmeier, Viviana Simon, Judith Aberg, David L. Reich, Florian Krammer, Carlos Cordon-Cardo Published Online28 Oct 2020 __Open Access DOI: 10.1126/science.abd7728* Abstract
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OCTOBER 22, 2020
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Enteroviral 3C protease activates the human NLRP1 inflammasome inairway epithelia
By Kim S. Robinson, Daniel Eng Thiam Teo, Kai Sen Tan, Gee Ann Toh, Hsiao Hui Ong, Chrissie Kaishi Lim, Kenneth Lay, Bijin Veonice Au, Tian Sheng Lew, Justin Jang Hann Chu, Vincent Tak Kwong Chow, De Yun Wang, Franklin L. Zhong, Bruno Reversade Published Online22 Oct 2020 __Full Access__Restricted Access DOI: 10.1126/science.aay2002* Abstract
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OCTOBER 20, 2020
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Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate By Sandhya Bangaru, Gabriel Ozorowski, Hannah L. Turner, Aleksandar Antanasijevic, Deli Huang, Xiaoning Wang, Jonathan L. Torres, Jolene K. Diedrich, Jing-Hui Tian, Alyse D. Portnoff, Nita Patel, Michael J. Massare, John R. Yates III, David Nemazee, James C. Paulson, Greg Glenn, Gale Smith, Andrew B. Ward Published Online20 Oct 2020 __Open Access DOI: 10.1126/science.abe1502* Abstract
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OCTOBER 15, 2020
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Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms By David E. Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V. Rezelj, Svenja Ulferts, Hannes Braberg, Alexander S. Jureka, Kirsten Obernier, Jeffrey Z. Guo, Jyoti Batra, Robyn M. Kaake, Andrew R. Weckstein, Tristan W. Owens, Meghna Gupta, Sergei Pourmal, Erron W. Titus, Merve Cakir, Margaret Soucheray, Michael McGregor, Zeynep Cakir, Gwendolyn Jang, Matthew J. O’Meara, Tia A. Tummino, Ziyang Zhang, Helene Foussard, Ajda Rojc, Yuan Zhou, Dmitry Kuchenov, Ruth Hüttenhain, Jiewei Xu, Manon Eckhardt, Danielle L. Swaney, Jacqueline M. Fabius, Manisha Ummadi, Beril Tutuncuoglu, Ujjwal Rathore, Maya Modak, Paige Haas, Kelsey M. Haas, Zun Zar Chi Naing, Ernst H. Pulido, Ying Shi, Inigo Barrio-Hernandez, Danish Memon, Eirini Petsalaki, Alistair Dunham, Miguel Correa Marrero, David Burke, Cassandra Koh, Thomas Vallet, Jesus A. Silvas, Caleigh M. Azumaya, Christian Billesbølle, Axel F. Brilot, Melody G. Campbell, Amy Diallo, Miles Sasha Dickinson, Devan Diwanji, Nadia Herrera, Nick Hoppe, Huong T. Kratochvil, Yanxin Liu, Gregory E. Merz, Michelle Moritz, Henry C. Nguyen, Carlos Nowotny, Cristina Puchades, Alexandrea N. Rizo, Ursula Schulze-Gahmen, Amber M. Smith, Ming Sun, Iris D. Young, Jianhua Zhao, Daniel Asarnow, Justin Biel, Alisa Bowen, Julian R. Braxton, Jen Chen, Cynthia M. Chio, Un Seng Chio, Ishan Deshpande, Loan Doan, Bryan Faust, Sebastian Flores, Mingliang Jin, Kate Kim, Victor L. Lam, Fei Li, Junrui Li, Yen-Li Li, Yang Li, Xi Liu, Megan Lo, Kyle E. Lopez, Arthur A. Melo, Frank R. Moss III, Phuong Nguyen, Joana Paulino, Komal Ishwar Pawar, Jessica K. Peters, Thomas H. Pospiech Jr., Maliheh Safari, Smriti Sangwan, Kaitlin Schaefer, Paul V. Thomas, Aye C. Thwin, Raphael Trenker, Eric Tse, Tsz Kin Martin Tsui, Feng Wang, Natalie Whitis, Zanlin Yu, Kaihua Zhang, Yang Zhang, Fengbo Zhou, Daniel Saltzberg, QCRG Structural Biology Consortium, Anthony J. Hodder, Amber S. Shun-Shion, Daniel M. Williams, Kris M. White, Romel Rosales, Thomas Kehrer, Lisa Miorin, Elena Moreno, Arvind H. Patel, Suzannah Rihn, Mir M. Khalid, Albert Vallejo-Gracia, Parinaz Fozouni, Camille R. Simoneau, Theodore L. Roth, David Wu, Mohd Anisul Karim, Maya Ghoussaini, Ian Dunham, Francesco Berardi, Sebastian Weigang, Maxime Chazal, Jisoo Park, James Logue, Marisa McGrath, Stuart Weston, Robert Haupt, C. James Hastie, Matthew Elliott, Fiona Brown, Kerry A. Burness, Elaine Reid, Mark Dorward, Clare Johnson, Stuart G. Wilkinson, Anna Geyer, Daniel M. Giesel, Carla Baillie, Samantha Raggett, Hannah Leech, Rachel Toth, Nicola Goodman, Kathleen C. Keough, Abigail L. Lind, Zoonomia Consortium, Reyna J. Klesh, Kafi R. Hemphill, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Travis Maures, Katherine S. Pollard, Andrej Sali, David A. Agard, Yifan Cheng, James S. Fraser, Adam Frost, Natalia Jura, Tanja Kortemme, Aashish Manglik, Daniel R. Southworth, Robert M. Stroud, Dario R. Alessi, Paul Davies, Matthew B. Frieman, Trey Ideker, Carmen Abate, Nolwenn Jouvenet, Georg Kochs, Brian Shoichet, Melanie Ott, Massimo Palmarini, Kevan M. Shokat, Adolfo García-Sastre, Jeremy A. Rassen, Robert Grosse, Oren S. Rosenberg, Kliment A. Verba, Christopher F. Basler, Marco Vignuzzi, Andrew A. Peden, Pedro Beltrao, Nevan J.Krogan
Published Online15 Oct 2020 __Open Access DOI: 10.1126/science.abe9403* Abstract
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OCTOBER 09, 2020
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REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters By Alina Baum, Dharani Ajithdoss, Richard Copin, Anbo Zhou, Kathryn Lanza, Nicole Negron, Min Ni, Yi Wei, Kusha Mohammadi, Bret Musser, Gurinder S. Atwal, Adelekan Oyejide, Yenny Goez-Gazi, John Dutton, Elizabeth Clemmons, Hilary M. Staples, Carmen Bartley, Benjamin Klaffke, Kendra Alfson, Michal Gazi, Olga Gonzalez, Edward Dick Jr., Ricardo Carrion Jr., Laurent Pessaint, Maciel Porto, Anthony Cook, Renita Brown, Vaneesha Ali, Jack Greenhouse, Tammy Taylor, Hanne Andersen, Mark G. Lewis, Neil Stahl, Andrew J. Murphy, George D. Yancopoulos, Christos A. Kyratsous Published Online09 Oct 2020 __Open Access DOI: 10.1126/science.abe2402* Abstract
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SEPTEMBER 29, 2020
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Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity By Ellen Shrock, Eric Fujimura, Tomasz Kula, Richard T. Timms, I-Hsiu Lee, Yumei Leng, Matthew L. Robinson, Brandon M. Sie, Mamie Z. Li, Yuezhou Chen, Jennifer Logue, Adam Zuiani, Denise McCulloch, Felipe J. N. Lelis, Stephanie Henson, Daniel R. Monaco, Meghan Travers, Shaghayegh Habibi, William A. Clarke, Patrizio Caturegli, Oliver Laeyendecker, Alicja Piechocka-Trocha, Jon Li, Ashok Khatri, Helen Y. Chu, MGH COVID-19 Collection & Processing Team, Alexandra-Chloé Villani, Kyle Kays, Marcia B. Goldberg, Nir Hacohen, Michael R. Filbin, Xu G. Yu, Bruce D. Walker, Duane R. Wesemann, H. Benjamin Larman, James A. Lederer, Stephen J. Elledge Published Online29 Sep 2020 __Open Access DOI: 10.1126/science.abd4250* Abstract
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SEPTEMBER 24, 2020
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Long-term collapse in fruit availability threatens Central Africanforest megafauna
By Emma R. Bush, Robin C. Whytock, Laila Bahaa-el-din, Stéphanie Bourgeois, Nils Bunnefeld, Anabelle W. Cardoso, Jean Thoussaint Dikangadissi, Pacôme Dimbonda, Edmond Dimoto, Josué Edzang Ndong, Kathryn J. Jeffery, David Lehmann, Loïc Makaga, Brice Momboua, Ludovic R. W. Momont, Caroline E. G. Tutin, Lee J. T. White, Alden Whittaker, Katharine Abernethy Published Online24 Sep 2020 __Full Access__Restricted Access DOI: 10.1126/science.abc7791* Abstract
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READ THE LATEST ISSUE OF _SCIENCE_20 NOVEMBER 2020
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