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THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. CORONAVIRUS RESEARCH COVID-19 RESEARCH In addition to Salk’s ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. These efforts range from understanding the structure of the virus to mobilizing the body’s immune reaction. Helping the World Breathe Easier 01 Professor Susan Kaech, who studies HARNESSING PLANTS INITIATIVE The Salk Institute’s Harnessing Plants Initiative (HPI) offers a bold, scalable solution that can be rapidly implemented. Plants are the original carbon scrubbers, removing CO 2 from the atmosphere and storing it in their biomass. Unfortunately, this carbon storage isoften temporary.
VIRTUAL 2021 CELL CYCLE MEETING Virtual 2021 Cell Cycle Meeting. Tuesday, June 22, 2021 – Friday, June 25, 2021. Sessions start at 8am PDT and end at 1pm PDT (-7 UTC) Virtual – Zoom meeting information will be provided one week prior to the event. Abstract Deadline: Abstract submission is now closed.VIRTUAL KITS
Virtual kits are sets of helper viruses (for expressing TVA, rabies glycoprotein (G) and/or marker genes) and G-deleted rabies vectors, that when used together, allow for monosynaptic circuit tracing. Cre-dependent kits use helper viruses with cre-dependent expression such that monosynaptic inputs to cre-expressing cells can be labeled. URI MANOR - SALK INSTITUTE FOR BIOLOGICAL STUDIES Manor developed a new deep learning tool that improves the quality of low-resolution microscopy images—an approach that could help democratize high-resolution microscopy and further increase the capabilities of cutting-edge microscopes. He discovered that a protein called Eps8 helps regulate the growth of microscopic “hairs”involved in
SIGNAL : SALK INSTITUTE GENOMIC ANALYSIS LABORATORY HOME PAGE Salk Institute Genomic Analysis Laboratory 10010 N. Torrey Pines Road La Jolla, CA 92037 Phone: (858) 453-4100 x1752 FAX: (858) 558-6379SATCHIDANANDA PANDA
Satchidananda Panda explores the genes, molecules and cells that keep the whole body on the same circadian clock. A section of the hypothalamus called the suprachiasmatic nucleus (SCN) lies at the center of the body’s master clock and gets input directly from light sensors in the eyes, keeping the rest of the body on schedule. CANNABINOIDS REMOVE PLAQUE-FORMING ALZHEIMER’S PROTEINS June 27, 2016. Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells. Preliminary lab studies at the Salk Institute find THC reduces beta amyloid proteins in human neurons SALK INSTITUTE FOR BIOLOGICAL STUDIESABOUTSCIENCEEVENTSNEWSENGAGERESEARCH AREAS Salk researchers combine foundational biological research with advanced biomedical technologies, keying in on five deadly cancers: breast (triple negative), brain (glioblastoma), pancreatic, lung and ovarian. ANNOUNCEMENT. Statement on the Current Operations at the Salk Institute due to COVID-19. The Salk campus remains closed to thepublic at
THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. CORONAVIRUS RESEARCH COVID-19 RESEARCH In addition to Salk’s ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. These efforts range from understanding the structure of the virus to mobilizing the body’s immune reaction. Helping the World Breathe Easier 01 Professor Susan Kaech, who studies HARNESSING PLANTS INITIATIVE The Salk Institute’s Harnessing Plants Initiative (HPI) offers a bold, scalable solution that can be rapidly implemented. Plants are the original carbon scrubbers, removing CO 2 from the atmosphere and storing it in their biomass. Unfortunately, this carbon storage isoften temporary.
VIRTUAL 2021 CELL CYCLE MEETING Virtual 2021 Cell Cycle Meeting. Tuesday, June 22, 2021 – Friday, June 25, 2021. Sessions start at 8am PDT and end at 1pm PDT (-7 UTC) Virtual – Zoom meeting information will be provided one week prior to the event. Abstract Deadline: Abstract submission is now closed.VIRTUAL KITS
Virtual kits are sets of helper viruses (for expressing TVA, rabies glycoprotein (G) and/or marker genes) and G-deleted rabies vectors, that when used together, allow for monosynaptic circuit tracing. Cre-dependent kits use helper viruses with cre-dependent expression such that monosynaptic inputs to cre-expressing cells can be labeled. URI MANOR - SALK INSTITUTE FOR BIOLOGICAL STUDIES Manor developed a new deep learning tool that improves the quality of low-resolution microscopy images—an approach that could help democratize high-resolution microscopy and further increase the capabilities of cutting-edge microscopes. He discovered that a protein called Eps8 helps regulate the growth of microscopic “hairs”involved in
SIGNAL : SALK INSTITUTE GENOMIC ANALYSIS LABORATORY HOME PAGE Salk Institute Genomic Analysis Laboratory 10010 N. Torrey Pines Road La Jolla, CA 92037 Phone: (858) 453-4100 x1752 FAX: (858) 558-6379SATCHIDANANDA PANDA
Satchidananda Panda explores the genes, molecules and cells that keep the whole body on the same circadian clock. A section of the hypothalamus called the suprachiasmatic nucleus (SCN) lies at the center of the body’s master clock and gets input directly from light sensors in the eyes, keeping the rest of the body on schedule. CANNABINOIDS REMOVE PLAQUE-FORMING ALZHEIMER’S PROTEINS June 27, 2016. Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells. Preliminary lab studies at the Salk Institute find THC reduces beta amyloid proteins in human neurons SALK NEWS - SALK INSTITUTE FOR BIOLOGICAL STUDIES Salk scientists reveal role of genetic switch in pigmentation and melanoma. May 18, 2021. LA JOLLA—Despite only accounting for about 1 percent of skin cancers, melanoma causes the majority of skin cancer-related deaths. While treatments for this serious disease do exist, these drugs can vary in effectiveness depending on theindividual.
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News Highlights. Feb 17, 2021 – Salk team reveals never-before-seen antibody binding, informing both liver cancer and antibody design Jun 29, 2020 – Salk researchers accelerate, expand COVID-19 research Apr 17, 2020 – Mysterious tuft cells found to play role in pancreatitis Oct 30, 2019 – Salk Institute hits play on new podcast series [click “BAD FAT” SUPPRESSES KILLER T CELLS FROM ATTACKING CANCER LA JOLLA—In order for cancer to grow and spread, it has to evade detection by our immune cells, particularly specialized “killer” T cells. Salk researchers led by Professor Susan Kaech have found that the environment inside tumors (the tumor microenvironment) contains an abundance of oxidized fat molecules, which, when ingested by the killer T cells, suppresses their ability to kill SIGNAL : SALK INSTITUTE GENOMIC ANALYSIS LABORATORY HOME PAGE Salk Institute Genomic Analysis Laboratory 10010 N. Torrey Pines Road La Jolla, CA 92037 Phone: (858) 453-4100 x1752 FAX: (858) 558-6379VIRTUAL KITS
Virtual kits are sets of helper viruses (for expressing TVA, rabies glycoprotein (G) and/or marker genes) and G-deleted rabies vectors, that when used together, allow for monosynaptic circuit tracing. Cre-dependent kits use helper viruses with cre-dependent expression such that monosynaptic inputs to cre-expressing cells can be labeled. CLINICAL STUDY FINDS EATING WITHIN A 10-HOUR WINDOW MAY LA JOLLA—Metabolic syndrome affects nearly 30 percent of the U.S. population, and increases the risk for type 2 diabetes, heart disease and stroke. But lifestyle interventions such as adopting a healthy diet and increasing physical exercise are difficult to maintain and, even when combined with medication, are often insufficient to fullymanage the disease.
FAQ ON TYPE 4 DIABETES What is type 4 diabetes? Salk scientists use this to describe age-related insulin resistance that occurs in lean, elderly people. While type 1 diabetes is a result of the immune system destroying insulin-producing cells and type 2 diabetes is caused by diet and obesity, type 4 diabetes is associated with older age, rather than weight gain. Type 3 diabetes is suggested for a type of insulin NEW PROTEIN HELPS CARNIVOROUS PLANTS SENSE AND TRAP THEIR The aging puzzle comes together Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together.; Dmitry Lyumkis – A passion for problem solving Assistant Professor Dmitry Lyumkis discusses what he loves about data and the scientific process, and which places inspire him outside the lab.DISCOVERIES
The microbiota are the microorganisms that colonize the body, but scientists are unsure about how they affect the brain. Professor Janelle Ayres, first author and former graduate student Yujung Michelle Lee and colleagues have identified a strain of E. coli bacteria that, when living in the guts of female mice, causes them to neglect their offspring. NEW METHOD COULD DEMOCRATIZE DEEP LEARNING-ENHANCED The aging puzzle comes together Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together.; Dmitry Lyumkis – A passion for problem solving Assistant Professor Dmitry Lyumkis discusses what he loves about data and the scientific process, and which places inspire him outside the lab. SALK INSTITUTE FOR BIOLOGICAL STUDIESABOUTSCIENCEEVENTSNEWSENGAGERESEARCH AREAS Salk researchers combine foundational biological research with advanced biomedical technologies, keying in on five deadly cancers: breast (triple negative), brain (glioblastoma), pancreatic, lung and ovarian. ANNOUNCEMENT. Statement on the Current Operations at the Salk Institute due to COVID-19. The Salk campus remains closed to thepublic at
THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. CORONAVIRUS RESEARCH COVID-19 RESEARCH In addition to Salk’s ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. These efforts range from understanding the structure of the virus to mobilizing the body’s immune reaction. Helping the World Breathe Easier 01 Professor Susan Kaech, who studies HARNESSING PLANTS INITIATIVE The Salk Institute’s Harnessing Plants Initiative (HPI) offers a bold, scalable solution that can be rapidly implemented. Plants are the original carbon scrubbers, removing CO 2 from the atmosphere and storing it in their biomass. Unfortunately, this carbon storage isoften temporary.
VIRTUAL 2021 CELL CYCLE MEETING Virtual 2021 Cell Cycle Meeting. Tuesday, June 22, 2021 – Friday, June 25, 2021. Sessions start at 8am PDT and end at 1pm PDT (-7 UTC) Virtual – Zoom meeting information will be provided one week prior to the event. Abstract Deadline: Abstract submission is now closed. SALK INSTITUTE FOR BIOLOGICAL STUDIESABOUTSCIENCEEVENTSNEWSENGAGERESEARCH AREAS Salk researchers combine foundational biological research with advanced biomedical technologies, keying in on five deadly cancers: breast (triple negative), brain (glioblastoma), pancreatic, lung and ovarian. ANNOUNCEMENT. Statement on the Current Operations at the Salk Institute due to COVID-19. The Salk campus remains closed to thepublic at
THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. CORONAVIRUS RESEARCH COVID-19 RESEARCH In addition to Salk’s ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. These efforts range from understanding the structure of the virus to mobilizing the body’s immune reaction. Helping the World Breathe Easier 01 Professor Susan Kaech, who studies HARNESSING PLANTS INITIATIVE The Salk Institute’s Harnessing Plants Initiative (HPI) offers a bold, scalable solution that can be rapidly implemented. Plants are the original carbon scrubbers, removing CO 2 from the atmosphere and storing it in their biomass. Unfortunately, this carbon storage isoften temporary.
VIRTUAL 2021 CELL CYCLE MEETING Virtual 2021 Cell Cycle Meeting. Tuesday, June 22, 2021 – Friday, June 25, 2021. Sessions start at 8am PDT and end at 1pm PDT (-7 UTC) Virtual – Zoom meeting information will be provided one week prior to the event. Abstract Deadline: Abstract submission is now closed. SALK NEWS - SALK INSTITUTE FOR BIOLOGICAL STUDIES Salk scientists reveal role of genetic switch in pigmentation and melanoma. May 18, 2021. LA JOLLA—Despite only accounting for about 1 percent of skin cancers, melanoma causes the majority of skin cancer-related deaths. While treatments for this serious disease do exist, these drugs can vary in effectiveness depending on theindividual.
HOME | HUNTER LAB
News Highlights. Feb 17, 2021 – Salk team reveals never-before-seen antibody binding, informing both liver cancer and antibody design Jun 29, 2020 – Salk researchers accelerate, expand COVID-19 research Apr 17, 2020 – Mysterious tuft cells found to play role in pancreatitis Oct 30, 2019 – Salk Institute hits play on new podcast series [click “BAD FAT” SUPPRESSES KILLER T CELLS FROM ATTACKING CANCER LA JOLLA—In order for cancer to grow and spread, it has to evade detection by our immune cells, particularly specialized “killer” T cells. Salk researchers led by Professor Susan Kaech have found that the environment inside tumors (the tumor microenvironment) contains an abundance of oxidized fat molecules, which, when ingested by the killer T cells, suppresses their ability to kill SIGNAL : SALK INSTITUTE GENOMIC ANALYSIS LABORATORY HOME PAGE Salk Institute Genomic Analysis Laboratory 10010 N. Torrey Pines Road La Jolla, CA 92037 Phone: (858) 453-4100 x1752 FAX: (858) 558-6379VIRTUAL KITS
Virtual kits are sets of helper viruses (for expressing TVA, rabies glycoprotein (G) and/or marker genes) and G-deleted rabies vectors, that when used together, allow for monosynaptic circuit tracing. Cre-dependent kits use helper viruses with cre-dependent expression such that monosynaptic inputs to cre-expressing cells can be labeled. CLINICAL STUDY FINDS EATING WITHIN A 10-HOUR WINDOW MAY LA JOLLA—Metabolic syndrome affects nearly 30 percent of the U.S. population, and increases the risk for type 2 diabetes, heart disease and stroke. But lifestyle interventions such as adopting a healthy diet and increasing physical exercise are difficult to maintain and, even when combined with medication, are often insufficient to fullymanage the disease.
FAQ ON TYPE 4 DIABETES What is type 4 diabetes? Salk scientists use this to describe age-related insulin resistance that occurs in lean, elderly people. While type 1 diabetes is a result of the immune system destroying insulin-producing cells and type 2 diabetes is caused by diet and obesity, type 4 diabetes is associated with older age, rather than weight gain. Type 3 diabetes is suggested for a type of insulin NEW PROTEIN HELPS CARNIVOROUS PLANTS SENSE AND TRAP THEIR The aging puzzle comes together Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together.; Dmitry Lyumkis – A passion for problem solving Assistant Professor Dmitry Lyumkis discusses what he loves about data and the scientific process, and which places inspire him outside the lab.DISCOVERIES
The microbiota are the microorganisms that colonize the body, but scientists are unsure about how they affect the brain. Professor Janelle Ayres, first author and former graduate student Yujung Michelle Lee and colleagues have identified a strain of E. coli bacteria that, when living in the guts of female mice, causes them to neglect their offspring. NEW METHOD COULD DEMOCRATIZE DEEP LEARNING-ENHANCED The aging puzzle comes together Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together.; Dmitry Lyumkis – A passion for problem solving Assistant Professor Dmitry Lyumkis discusses what he loves about data and the scientific process, and which places inspire him outside the lab. SALK INSTITUTE FOR BIOLOGICAL STUDIESABOUTSCIENCEEVENTSNEWSENGAGERESEARCH AREAS Salk researchers combine foundational biological research with advanced biomedical technologies, keying in on five deadly cancers: breast (triple negative), brain (glioblastoma), pancreatic, lung and ovarian. ANNOUNCEMENT. Statement on the Current Operations at the Salk Institute due to COVID-19. The Salk campus remains closed to thepublic at
THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. CORONAVIRUS RESEARCH COVID-19 RESEARCH In addition to Salk’s ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. These efforts range from understanding the structure of the virus to mobilizing the body’s immune reaction. Helping the World Breathe Easier 01 Professor Susan Kaech, who studies HARNESSING PLANTS INITIATIVE The Salk Institute’s Harnessing Plants Initiative (HPI) offers a bold, scalable solution that can be rapidly implemented. Plants are the original carbon scrubbers, removing CO 2 from the atmosphere and storing it in their biomass. Unfortunately, this carbon storage isoften temporary.
VIRTUAL 2021 CELL CYCLE MEETING Virtual 2021 Cell Cycle Meeting. Tuesday, June 22, 2021 – Friday, June 25, 2021. Sessions start at 8am PDT and end at 1pm PDT (-7 UTC) Virtual – Zoom meeting information will be provided one week prior to the event. Abstract Deadline: Abstract submission is now closed. URI MANOR - SALK INSTITUTE FOR BIOLOGICAL STUDIES Manor developed a new deep learning tool that improves the quality of low-resolution microscopy images—an approach that could help democratize high-resolution microscopy and further increase the capabilities of cutting-edge microscopes. He discovered that a protein called Eps8 helps regulate the growth of microscopic “hairs”involved in
SIGNAL : SALK INSTITUTE GENOMIC ANALYSIS LABORATORY HOME PAGE Salk Institute Genomic Analysis Laboratory 10010 N. Torrey Pines Road La Jolla, CA 92037 Phone: (858) 453-4100 x1752 FAX: (858) 558-6379HOME | SHAW LAB
Welcome to the Shaw lab. Reuben Shaw investigates mechanisms connecting cell metabolism to growth control. His lab utilizes biochemistry and genetic mouse models to study an ancient signaling pathway that is deregulated in both cancer and type 2 diabetes. The central goal of our research is to elucidate mechanisms by which cellsconnect
WOLFGANG BUSCH
Wolfgang Busch uses a systems genetics approach—which combines techniques from genetics, genomics and other science fields—to understand how root growth in given environments is determined by a plant’s genes. Genome-wide association studies correlate genetic variation with physical characteristics, such as having long or shortroots.
CANNABINOIDS REMOVE PLAQUE-FORMING ALZHEIMER’S PROTEINS June 27, 2016. Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells. Preliminary lab studies at the Salk Institute find THC reduces beta amyloid proteins in human neurons SALK INSTITUTE FOR BIOLOGICAL STUDIESABOUTSCIENCEEVENTSNEWSENGAGERESEARCH AREAS Salk researchers combine foundational biological research with advanced biomedical technologies, keying in on five deadly cancers: breast (triple negative), brain (glioblastoma), pancreatic, lung and ovarian. ANNOUNCEMENT. Statement on the Current Operations at the Salk Institute due to COVID-19. The Salk campus remains closed to thepublic at
THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. CORONAVIRUS RESEARCH COVID-19 RESEARCH In addition to Salk’s ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. These efforts range from understanding the structure of the virus to mobilizing the body’s immune reaction. Helping the World Breathe Easier 01 Professor Susan Kaech, who studies HARNESSING PLANTS INITIATIVE The Salk Institute’s Harnessing Plants Initiative (HPI) offers a bold, scalable solution that can be rapidly implemented. Plants are the original carbon scrubbers, removing CO 2 from the atmosphere and storing it in their biomass. Unfortunately, this carbon storage isoften temporary.
VIRTUAL 2021 CELL CYCLE MEETING Virtual 2021 Cell Cycle Meeting. Tuesday, June 22, 2021 – Friday, June 25, 2021. Sessions start at 8am PDT and end at 1pm PDT (-7 UTC) Virtual – Zoom meeting information will be provided one week prior to the event. Abstract Deadline: Abstract submission is now closed. URI MANOR - SALK INSTITUTE FOR BIOLOGICAL STUDIES Manor developed a new deep learning tool that improves the quality of low-resolution microscopy images—an approach that could help democratize high-resolution microscopy and further increase the capabilities of cutting-edge microscopes. He discovered that a protein called Eps8 helps regulate the growth of microscopic “hairs”involved in
SIGNAL : SALK INSTITUTE GENOMIC ANALYSIS LABORATORY HOME PAGE Salk Institute Genomic Analysis Laboratory 10010 N. Torrey Pines Road La Jolla, CA 92037 Phone: (858) 453-4100 x1752 FAX: (858) 558-6379HOME | SHAW LAB
Welcome to the Shaw lab. Reuben Shaw investigates mechanisms connecting cell metabolism to growth control. His lab utilizes biochemistry and genetic mouse models to study an ancient signaling pathway that is deregulated in both cancer and type 2 diabetes. The central goal of our research is to elucidate mechanisms by which cellsconnect
WOLFGANG BUSCH
Wolfgang Busch uses a systems genetics approach—which combines techniques from genetics, genomics and other science fields—to understand how root growth in given environments is determined by a plant’s genes. Genome-wide association studies correlate genetic variation with physical characteristics, such as having long or shortroots.
CANNABINOIDS REMOVE PLAQUE-FORMING ALZHEIMER’S PROTEINS June 27, 2016. Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells. Preliminary lab studies at the Salk Institute find THC reduces beta amyloid proteins in human neurons VIRTUAL 2021 CELL CYCLE MEETING Virtual 2021 Cell Cycle Meeting. Tuesday, June 22, 2021 – Friday, June 25, 2021. Sessions start at 8am PDT and end at 1pm PDT (-7 UTC) Virtual – Zoom meeting information will be provided one week prior to the event. Abstract Deadline: Abstract submission is now closed.EVENTS | CATEGORIES
The aging puzzle comes together Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together.; Dmitry Lyumkis – A passion for problem solving Assistant Professor Dmitry Lyumkis discusses what he loves about data and the scientific process, and which places inspire him outside the lab. SIGNAL : SALK INSTITUTE GENOMIC ANALYSIS LABORATORY HOME PAGE Salk Institute Genomic Analysis Laboratory 10010 N. Torrey Pines Road La Jolla, CA 92037 Phone: (858) 453-4100 x1752 FAX: (858) 558-6379 “BAD FAT” SUPPRESSES KILLER T CELLS FROM ATTACKING CANCER 1 day ago · LA JOLLA—In order for cancer to grow and spread, it has to evade detection by our immune cells, particularly specialized “killer” T cells. Salk researchers led by Professor Susan Kaech have found that the environment inside tumors (the tumor microenvironment) contains an abundance of oxidized fat molecules, which, when ingested by the killer T cells, suppresses their abilityto kill
NEUROSCIENCE
The aging puzzle comes together Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together.; Dmitry Lyumkis – A passion for problem solving Assistant Professor Dmitry Lyumkis discusses what he loves about data and the scientific process, and which places inspire him outside the lab.VIRTUAL KITS
Virtual kits are sets of helper viruses (for expressing TVA, rabies glycoprotein (G) and/or marker genes) and G-deleted rabies vectors, that when used together, allow for monosynaptic circuit tracing. Cre-dependent kits use helper viruses with cre-dependent expression such that monosynaptic inputs to cre-expressing cells can be labeled.DISCOVERIES
The microbiota are the microorganisms that colonize the body, but scientists are unsure about how they affect the brain. Professor Janelle Ayres, first author and former graduate student Yujung Michelle Lee and colleagues have identified a strain of E. coli bacteria that, when living in the guts of female mice, causes them to neglect their offspring. NEW PROTEIN HELPS CARNIVOROUS PLANTS SENSE AND TRAP THEIR The aging puzzle comes together Aging is a complex puzzle, but by applying a collaborative, multidisciplinary approach, Salk scientists are putting its many pieces together.; Dmitry Lyumkis – A passion for problem solving Assistant Professor Dmitry Lyumkis discusses what he loves about data and the scientific process, and which places inspire him outside the lab.SATCHIDANANDA PANDA
Satchidananda Panda explores the genes, molecules and cells that keep the whole body on the same circadian clock. A section of the hypothalamus called the suprachiasmatic nucleus (SCN) lies at the center of the body’s master clock and gets input directly from light sensors in the eyes, keeping the rest of the body on schedule. COMPUTATIONAL BIOLOGY Wolffia, also known as duckweed, is the fastest-growing plant known, but the genetics underlying this strange little plant’s success have long been unknown to scientists.Now, a multi-investigator effort led by Todd Michael, research professor and first author of the paper, along with coauthor and Professor Joseph Ecker, reports new findings about the plant’s genome that explain how it is SALK INSTITUTE FOR BIOLOGICAL STUDIESABOUTSCIENCEEVENTSNEWSENGAGERESEARCH AREAS Salk researchers combine foundational biological research with advanced biomedical technologies, keying in on five deadly cancers: breast (triple negative), brain (glioblastoma), pancreatic, lung and ovarian. ANNOUNCEMENT. Statement on the Current Operations at the Salk Institute due to COVID-19. The Salk campus remains closed to thepublic at
CORONAVIRUS RESEARCH COVID-19 RESEARCH In addition to Salk’s ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. These efforts range from understanding the structure of the virus to mobilizing the body’s immune reaction. Helping the World Breathe Easier 01 Professor Susan Kaech, who studies THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. PROGRAMS - SALK INSTITUTE FOR BIOLOGICAL STUDIES The Salk Mobile Science Lab travels to middle schools throughout San Diego County, bringing a free, three-day program designed to deliver a science experience students can’t get from a textbook. Students study fruit flies under a microscope, isolate plant DNA and learn about techniques of DNA analysis, all hands-on activities proven to VIRTUAL 2021 CELL CYCLE MEETING Virtual 2021 Cell Cycle Meeting. Tuesday, June 22, 2021 – Friday, June 25, 2021. Sessions start at 8am PDT and end at 1pm PDT (-7 UTC) Virtual – Zoom meeting information will be provided one week prior to the event. Abstract Deadline: Abstract submission is now closed.FLOW CYTOMETRY
Salk Institute for Biological Studies. 10010 N Torrey Pines Rd. La Jolla, CA 92037. Telephone: (858) 453-4100. Carolyn O’Connor. Managing Director, Cytometry Core. (858) 453-4100 x1728.coconnor@salk.edu.
URI MANOR - SALK INSTITUTE FOR BIOLOGICAL STUDIES Manor developed a new deep learning tool that improves the quality of low-resolution microscopy images—an approach that could help democratize high-resolution microscopy and further increase the capabilities of cutting-edge microscopes. He discovered that a protein called Eps8 helps regulate the growth of microscopic “hairs”involved in
SYMPHONY AT SALK
BioMed Realty Cassandra and Fred Dotzler Anne and Edwin Hunter/Olive Tupper Foundation Paula Tallal, PhD Toby WolfT-DNA PRIMER DESIGN
2. SALK T-DNA verification primer design. The program will pick up LP and RP for you. Its product size is around 900-1100 bps. If you want to confirm whether the design is right, simply cut and paste the LP and RP sequences together (you can cut/paste whole returned primer info line) to the blast textarea on the tdnaexpress page, hit "Return" if only one line of text and submit it. SALK INSTITUTE SECURE FILE TRANSFER Salk Institute Secure File Transfer. Secure File Transfer. 1) Enter Your Name (optional) 2) Enter Recipient Email Address. 3) Click Browse And Select A File. 4) Click Upload File. A Web Link To Your File. Will Be Sent To The Email Address. To Send To Many People, Send The Link. SALK INSTITUTE FOR BIOLOGICAL STUDIESABOUTSCIENCEEVENTSNEWSENGAGERESEARCH AREAS Salk researchers combine foundational biological research with advanced biomedical technologies, keying in on five deadly cancers: breast (triple negative), brain (glioblastoma), pancreatic, lung and ovarian. ANNOUNCEMENT. Statement on the Current Operations at the Salk Institute due to COVID-19. The Salk campus remains closed to thepublic at
CORONAVIRUS RESEARCH COVID-19 RESEARCH In addition to Salk’s ongoing collaborative research areas that explore fundamental biological questions relevant to COVID-19, several new, coronavirus-specific projects have recently launched. These efforts range from understanding the structure of the virus to mobilizing the body’s immune reaction. Helping the World Breathe Easier 01 Professor Susan Kaech, who studies THE NOVEL CORONAVIRUS’ SPIKE PROTEIN PLAYS ADDITIONAL KEY LA JOLLA—Scientists have known for a while that SARS-CoV-2’s distinctive “spike” proteins help the virus infect its host by latching on to healthy cells. Now, a major new study shows that the virus spike proteins (which behave very differently than those safely encoded by vaccines) also play a key role in the disease itself. PROGRAMS - SALK INSTITUTE FOR BIOLOGICAL STUDIES The Salk Mobile Science Lab travels to middle schools throughout San Diego County, bringing a free, three-day program designed to deliver a science experience students can’t get from a textbook. Students study fruit flies under a microscope, isolate plant DNA and learn about techniques of DNA analysis, all hands-on activities proven to VIRTUAL 2021 CELL CYCLE MEETING Virtual 2021 Cell Cycle Meeting. Tuesday, June 22, 2021 – Friday, June 25, 2021. Sessions start at 8am PDT and end at 1pm PDT (-7 UTC) Virtual – Zoom meeting information will be provided one week prior to the event. Abstract Deadline: Abstract submission is now closed.FLOW CYTOMETRY
Salk Institute for Biological Studies. 10010 N Torrey Pines Rd. La Jolla, CA 92037. Telephone: (858) 453-4100. Carolyn O’Connor. Managing Director, Cytometry Core. (858) 453-4100 x1728.coconnor@salk.edu.
URI MANOR - SALK INSTITUTE FOR BIOLOGICAL STUDIES Manor developed a new deep learning tool that improves the quality of low-resolution microscopy images—an approach that could help democratize high-resolution microscopy and further increase the capabilities of cutting-edge microscopes. He discovered that a protein called Eps8 helps regulate the growth of microscopic “hairs”involved in
SYMPHONY AT SALK
BioMed Realty Cassandra and Fred Dotzler Anne and Edwin Hunter/Olive Tupper Foundation Paula Tallal, PhD Toby WolfT-DNA PRIMER DESIGN
2. SALK T-DNA verification primer design. The program will pick up LP and RP for you. Its product size is around 900-1100 bps. If you want to confirm whether the design is right, simply cut and paste the LP and RP sequences together (you can cut/paste whole returned primer info line) to the blast textarea on the tdnaexpress page, hit "Return" if only one line of text and submit it. SALK INSTITUTE SECURE FILE TRANSFER Salk Institute Secure File Transfer. Secure File Transfer. 1) Enter Your Name (optional) 2) Enter Recipient Email Address. 3) Click Browse And Select A File. 4) Click Upload File. A Web Link To Your File. Will Be Sent To The Email Address. To Send To Many People, Send The Link. PROGRAMS - SALK INSTITUTE FOR BIOLOGICAL STUDIES The Salk Mobile Science Lab travels to middle schools throughout San Diego County, bringing a free, three-day program designed to deliver a science experience students can’t get from a textbook. Students study fruit flies under a microscope, isolate plant DNA and learn about techniques of DNA analysis, all hands-on activities proven to RESEARCH ADVANCES ONE STEP CLOSER TO STEM CELL THERAPY FOR LA JOLLA—Type 1 diabetes, which arises when the pancreas doesn’t create enough insulin to control levels of glucose in the blood, is a disease that currently has no cure and is difficult for most patients to manage. Scientists at the Salk Institute are developing a promising approach for treating it: using stem cells to create insulin-producing cells (called beta cells) that could replaceCHRISTINA TOWERS
The Approach. Towers is using a combination of DNA-editing techniques, light-based genetic manipulation (optogenetics), three-dimensional miniature organs (“organoids”), and detailed imaging to uncover how cancer cells recycle both their own nutrients and the power-generating structures called mitochondria in order to survive.HOME | SHAW LAB
Welcome to the Shaw lab. Reuben Shaw investigates mechanisms connecting cell metabolism to growth control. His lab utilizes biochemistry and genetic mouse models to study an ancient signaling pathway that is deregulated in both cancer and type 2 diabetes. The central goal of our research is to elucidate mechanisms by which cellsconnect
RESEARCH | SONOGENETICS Cell cycle and cancer. Using time-lapse microscopy, we showed that nuclear envelope (NE) formation is mediated by reshaping of the endoplasmic reticulum and not as previously thought by vesicle fusion.JAN KARLSEDER
The Approach. Jan Karlseder studies the role of telomeres throughout a cell’s proliferative cycle—from the time the cell starts copying its genetic material to the time it divides into two new cells, as well as throughout the cell’s life—from when a young cell emerges through cell division to when an old cell permanently “retires” (becomes senescent) or dies. ABOUT | SONOGENETICS Ultrasound is ideally suited for noninvasive manipulation as it can focus easily through the skin and thin bone. Also, sound can travel quickly (1500 m/s in water) and a well-designed transducer-amplifier-waveform generator can generate stimulus pulses of varying duration (10 milliseconds) and at PEOPLE | SONOGENETICS Martin Hetzer received his Ph.D. in 1997 from the University of Vienna, Austria and completed his postdoctoral training at the European Molecular Biology Lab in Heidelberg, Germany.JOANNE CHORY
Joanne Chory is leading the Salk Institute’s Harnessing Plants Initiative (HPI), an innovative, scalable and bold approach to fight climate change by optimizing a plant’s natural ability to capture and store carbon and adapt to diverse climate conditions. Chory and the HPI team aim to help plants grow bigger, more robust root systemsthat
SALK INSTITUTE SECURE FILE TRANSFER Salk Institute Secure File Transfer. Secure File Transfer. 1) Enter Your Name (optional) 2) Enter Recipient Email Address. 3) Click Browse And Select A File. 4) Click Upload File. A Web Link To Your File. Will Be Sent To The Email Address. To Send To Many People, Send The Link.Salk
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Salk scientist Ronald Evans receives a 2020 NOMIS DistinguishedScientist Award
April 14, 2020
OUR SCIENCE
Learn more about research that strives to unlock the fundamental principles of biology.ANNOUNCEMENT
Salk minimizes on-site staff and takes additional steps around coronavirus (COVID-19) The Institute is taking additional steps to minimize opportunities for viral transmission through the community.March 6, 2020
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Now more than ever. Basic science is essential to our health. Your partnership allows our scientists to accelerate the pace of high-risk, high-reward discoveries that have the potential to benefit the health of all humanity—be it cancer, Alzheimer’s disease, climate change, infectious diseases or more. SCIENTIFIC INITIATIVE Harnessing Plants Initiative: The Salk Solution There are many ways to address the issue of climate change, and here at Salk we focus on making plants much more efficient at capturing andstoring carbon.
SCIENTIFIC INITIATIVE Conquering Cancer Initiative Salk researchers combine foundational biological research with advanced biomedical technologies, keying in on five deadly cancers: breast (triple negative), brain (glioblastoma), pancreatic, lung andovarian.
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Salk Institute hits play on new podcast series "Where Cures Begin" explores the lives of scientists and discoveriesat the Institute
October 30, 2019
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Through education and volunteerism, we share our passion.MEET A SCIENTIST
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Clayton Foundation Laboratories for Peptide BiologyNEWS
Plant geneticist Todd Michael joins Salk Institute Scientist who studies plant genetic diversity appointed to Salk faculty as a research professorApril 6, 2020
NEWS
Salk Institute appoints Leona Flores as executive director of SalkCancer Center
March 26, 2020
NEWS
How plants sound the alarm about danger Team led by Salk scientists provides a detailed picture of how plant hormones communicate through gene regulationMarch 13, 2020
NEWS
Eat less, live longer Salk scientists show how caloric restriction prevents negative effectsof aging in cells
February 27, 2020
NEWS
The Salk Institute to receive $12.5 million gift from Hess Corporation to accelerate development of plant-based carbon captureand storage
February 25, 2020
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Altered potassium levels in neurons may cause mood swings in bipolardisorder
Salk researchers also find additional differences between the neurons of people with bipolar disorder who respond to lithium and those whodon’t
February 19, 2020
NEWS
Imaging study of key viral structure shows how HIV drugs work atatomic level
Salk Institute findings will help inform the development of new and improved treatments for HIVJanuary 30, 2020
NEWS
The first roadmap for ovarian aging Scientists discover how non-human primate ovaries age, with implications for human fertilityJanuary 30, 2020
NEWS
Salk scientists link rapid brain growth in autism to DNA damage During development, cells generated from people with autism have frequent breaks in the DNA of certain genesJanuary 30, 2020
NEWS
Salk Institute welcomes new trustees Larry Jennings, Jr., and TimothySchoen
January 28, 2020
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