WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

NEW PAGE — WELCOME TO THE ZONCU LAB mechanisms of nutrient signal integration at the lysosome; inter-organelle communication in metabolic control; bottom-up reconstitution and chemical manipulation of lysosomal signaling WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

NEW PAGE — WELCOME TO THE ZONCU LAB mechanisms of nutrient signal integration at the lysosome; inter-organelle communication in metabolic control; bottom-up reconstitution and chemical manipulation of lysosomal signaling WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

NEW PAGE — WELCOME TO THE ZONCU LAB mechanisms of nutrient signal integration at the lysosome; inter-organelle communication in metabolic control; bottom-up reconstitution and chemical manipulation of lysosomal signaling WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

NEW PAGE — WELCOME TO THE ZONCU LAB mechanisms of nutrient signal integration at the lysosome; inter-organelle communication in metabolic control; bottom-up reconstitution and chemical manipulation of lysosomal signaling WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

NEW PAGE — WELCOME TO THE ZONCU LAB mechanisms of nutrient signal integration at the lysosome; inter-organelle communication in metabolic control; bottom-up reconstitution and chemical manipulation of lysosomal signaling WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

NEW PAGE — WELCOME TO THE ZONCU LAB mechanisms of nutrient signal integration at the lysosome; inter-organelle communication in metabolic control; bottom-up reconstitution and chemical manipulation of lysosomal signaling WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

NEW PAGE — WELCOME TO THE ZONCU LAB mechanisms of nutrient signal integration at the lysosome; inter-organelle communication in metabolic control; bottom-up reconstitution and chemical manipulation of lysosomal signaling WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

WELCOME TO THE ZONCU LABSCIENCEPAPERSPEOPLENEWSLAB FUNCONTACT Welcome to the Zoncu lab. Home. Science. Projects. MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL. BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab. SCIENCE — WELCOME TO THE ZONCU LAB To tackle these questions, we focus on the lysosome as our model system. Using advanced live cell microscopy, in vitro biochemical assays, and high throughput protein and metabolite profiling, we are discovering wonderful new properties of this organelle, which has traditionally been viewed as a metabolic end-point. PAPERS — WELCOME TO THE ZONCU LAB Selected publications. 2020. Davis, O.B., Shin, H.R., Lim, C.-Y., Wu, E.Y., Kukurugya, M., Maher, C.F., Perera, R.M., Ordonez, M.P., Zoncu, R¶., 2020.NPC1-mTORC1 PEOPLE — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Z-Lab, October 2019. Front row: Nikki Cheung, Jiayi Luo, Martina Spacci, Oliver Davis, Claire Maher. Standing: Roberto Zoncu, Rose Citron, Rosalie Lawrence (special guest), Subhrajit Banerjee, Regina Shin, Regina Baur (special guest), Justin Zhang, Hannah Nilsson, Madison Lehmer, Chun-Yan Lim. Roberto

Zoncu (PI)

CONTACT — WELCOME TO THE ZONCU LAB The Zoncu Lab, Li Ka Shing Center for Biomedical Sciences Room 330F. University of California at Berkeley Berkeley, CA 94720. Tel: (510) 664-7108 rzoncu@berkeley.edu. pics from around the Bay .. LAB FUN — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. Kyle's end of rotation dinner, Ohgane 11/10/2017. Ronja's farewell veggie BBQ, Alvarado Park, 7/24/2017. Lab

Hike at

BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION … BOTTOM-UP RECONSTITUTION AND CHEMICAL MANIPULATION OF LYSOSOMAL SIGNALING. As cell biologists and biochemists, we believe that one cannot truly understand a biological process unless some, or all, of its key features can be recreated in a test tube. This is especially true for lysosomal nutrient signaling, a process of remarkable

complexity

MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE … MECHANISMS OF NUTRIENT SIGNAL INTEGRATION AT THE LYSOSOME. The molecular mechanisms through which cells sense nutrients remain largely unknown, but their elucidation is key to our understanding of metabolic regulation both in normal and disease states. At the center of nutrient sensing and growth regulation is an ancient protein kinase

known as

INTER-ORGANELLE COMMUNICATION IN METABOLIC CONTROL The MCSs provide the lysosome with a direct route for the exchange lipids, ions and other metabolically relevant signals. However, the full range of inter-organelle interactions, and how they impact lysosome-dependent metabolic programs (i.e. mTORC1 signaling) are wide-open questions. Combining live cell microscopy, high-throughput

genetic

NEWS — WELCOME TO THE ZONCU LAB Welcome to the Zoncu lab. 5/12/2021 Two first-year MCB students join our lab: Peter Cathey and Julian Yano (jointly with Greg Barton’s lab). Welcome Peter and Julian! 3/1/2021 Roberta Peruzzo, an incoming postdoctoral scientist and fellow of the Italian Association for Cancer Research (AIRC) joins our lab.

* Home

* Science

*

Projects

* Mechanisms of nutrient sensing by the lysosome * Regulating lysosomal composition and function * Mechanisms of autolysosome formation

* Papers

* People

* News

* Lab Fun

* Contact

WELCOME TO THE ZONCU LAB

* Home

* Science

* Projects

* Mechanisms of nutrient sensing by the lysosome * Regulating lysosomal composition and function * Mechanisms of autolysosome formation

* Papers

* People

* News

* Lab Fun

* Contact

* Menu

PrevNext

LYSOSOMES IN A FIELD