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EUROFEVER PROJECT
A diagnostic Flow-chart for children with suspected monogenic Periodic Fever The Diagnostic score and the diagnostic flow chart (see the Figure) are aimed to provide an evidence-based tool to General Pediatricians that usually observe for the first time children with periodic fevers. Its aim is to timely select those patients at higher risk to carry mutations of known genes.DRUG THERAPY
A 4 to 6 week trial of a single NSAID is necessary to assess its efficacy. However, since NSAIDs are not disease-modifying drugs (i.e. they are not able to modify the course of the disease), they are used more to treat pain, stiffness and fever associated with systemicarthritis.
INFORMATION ON PAEDIATRIC RHEUMATIC DISEASES 3. At the moment for children with rheumatic diseases on medication, we recommend to continue all therapies as usual. 4. Don’t stop your medications including methotrexate (MTX) and biologics, without consulting your rheumatologist. This may cause a flare of your rheumatic disease. 5. PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALS The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisation JUVENILE DERMATOMYOSITIS Juvenile dermatomyositis (JDM) is a rare disease that affects muscles and skin. A disease is defined as "juvenile" when it starts before the age of 16. Juvenile dermatomyositis belongs to a group of conditions that are thought to be autoimmune diseases. Usually the immune system helps us to fight infections. In autoimmune diseases, the immuneSCLERODERMA
Scleroderma is an inflammatory disease but the reason for the inflammation has not been discovered yet. It is probably an autoimmune disease, which means that the child’s immune system reacts against itself. The inflammation causes swelling, heat and then an overproduction of fibrous (scar) tissue.BEHCET’S DISEASE
Behçet’s syndrome, or Behçet’s disease (BD), is a chronic inflammatory condition of unknown cause that leads to inflammation of blood vessels throughout the body (systemic vasculitis).The mucosa (tissue that produces mucous, which is found in the lining of the digestive, genital and urinary organs) and skin are affected and the main symptoms are recurrent oral and genital ulcers and eye JUVENILE IDIOPATHIC ARTHRITIS Juvenile idiopathic arthritis (JIA) is a chronic disease characterised by persistent joint inflammation; the typical signs of joint inflammation are pain, swelling and limitation of movement. evidence-based. consensus opinion. 2016.EUROFEVER PROJECT
The Eurofever project includes the following actions: a survey on the prevalence of diagnosed or suspected autoinflammatory diseases among all European Paediatric Rheumatology Centers. an international Registry for Autoinflammatory diseases. a survey on the efficacy of treatment in these disorders. elaboration of outcome measures forpossible
INFORMATION ON PAEDIATRIC RHEUMATIC DISEASESPOLSKA POLANDMEXICOSOUTH AFRICASLOVENSKO SLOVAKIAITALIA ITALYECUADOR Information on Paediatric Rheumatic Diseases. PRES recommendations in the corona era- COVID-19. 1. Be updated and follow the individual country’s Ministry of Health/National public health care body’s recommendations. 2. Ensure you meticulously follow all hygiene recommendations. Please note that the newcoronavirus may remain viablefor hour
EUROFEVER PROJECT
A diagnostic Flow-chart for children with suspected monogenic Periodic Fever The Diagnostic score and the diagnostic flow chart (see the Figure) are aimed to provide an evidence-based tool to General Pediatricians that usually observe for the first time children with periodic fevers. Its aim is to timely select those patients at higher risk to carry mutations of known genes.DRUG THERAPY
A 4 to 6 week trial of a single NSAID is necessary to assess its efficacy. However, since NSAIDs are not disease-modifying drugs (i.e. they are not able to modify the course of the disease), they are used more to treat pain, stiffness and fever associated with systemicarthritis.
INFORMATION ON PAEDIATRIC RHEUMATIC DISEASES 3. At the moment for children with rheumatic diseases on medication, we recommend to continue all therapies as usual. 4. Don’t stop your medications including methotrexate (MTX) and biologics, without consulting your rheumatologist. This may cause a flare of your rheumatic disease. 5. PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALS The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisation JUVENILE DERMATOMYOSITIS Juvenile dermatomyositis (JDM) is a rare disease that affects muscles and skin. A disease is defined as "juvenile" when it starts before the age of 16. Juvenile dermatomyositis belongs to a group of conditions that are thought to be autoimmune diseases. Usually the immune system helps us to fight infections. In autoimmune diseases, the immuneSCLERODERMA
Scleroderma is an inflammatory disease but the reason for the inflammation has not been discovered yet. It is probably an autoimmune disease, which means that the child’s immune system reacts against itself. The inflammation causes swelling, heat and then an overproduction of fibrous (scar) tissue.BEHCET’S DISEASE
Behçet’s syndrome, or Behçet’s disease (BD), is a chronic inflammatory condition of unknown cause that leads to inflammation of blood vessels throughout the body (systemic vasculitis).The mucosa (tissue that produces mucous, which is found in the lining of the digestive, genital and urinary organs) and skin are affected and the main symptoms are recurrent oral and genital ulcers and eye JUVENILE IDIOPATHIC ARTHRITIS Juvenile idiopathic arthritis (JIA) is a chronic disease characterised by persistent joint inflammation; the typical signs of joint inflammation are pain, swelling and limitation of movement. evidence-based. consensus opinion. 2016.EUROFEVER PROJECT
The Eurofever project includes the following actions: a survey on the prevalence of diagnosed or suspected autoinflammatory diseases among all European Paediatric Rheumatology Centers. an international Registry for Autoinflammatory diseases. a survey on the efficacy of treatment in these disorders. elaboration of outcome measures forpossible
INFORMATION ON PAEDIATRIC RHEUMATIC DISEASES Information on Paediatric Rheumatic Diseases. PRES recommendations in the corona era- COVID-19. 1. Be updated and follow the individual country’s Ministry of Health/National public health care body’s recommendations. 2. Ensure you meticulously follow all hygiene recommendations. Please note that the newcoronavirus may remain viablefor hour
PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALS The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisationDRUG THERAPY
A 4 to 6 week trial of a single NSAID is necessary to assess its efficacy. However, since NSAIDs are not disease-modifying drugs (i.e. they are not able to modify the course of the disease), they are used more to treat pain, stiffness and fever associated with systemicarthritis.
PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALS The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisation AUTOINFLAMMATORY DISEASES 1. GENERAL INTRODUCTION TO AUTOINFLAMMATORY DISEASES. 1.1 General introduction. Recent progress in research has clearly shown that some rare fever diseases are caused by genetic defects. In some of diseases there may be several members of a single family who suffer fromrecurrent fevers.
PAEDIATRIC RHEUMATIC DISEASES Version of 2016. Juvenile Idiopathic Arthritis. Systemic Lupus Erythematosus. Antiphospholipid antibodies, Neonatal lupus. Juvenile Dermatomyositis. Scleroderma. Juvenile Spondyloarthritis / Enthesitis Related Arthritis (SpA-ERA)EUROFEVER PROJECT
The Eurofever project includes the following actions: a survey on the prevalence of diagnosed or suspected autoinflammatory diseases among all European Paediatric Rheumatology Centers. an international Registry for Autoinflammatory diseases. a survey on the efficacy of treatment in these disorders. elaboration of outcome measures forpossible
JUVENILE SPONDYLOARTHRITIS / ENTHESITIS RELATED ARTHRITIS As mentioned above, juvenile spondyloarthritis is the name for a group of diseases; the clinical features may overlap with each other, including axial and peripheral spondyloarthritis, ankylosing spondylitis, undifferentiated spondyloarthritis, psoriatic arthritis, reactive arthritis and arthritis associated with Crohn’s disease andulcerative colitis.
FAMILIAL MEDITERRANEAN FEVER Familial Mediterranean Fever (FMF) is a genetically transmitted disease. Patients suffer from recurrent bouts of fever, accompanied by abdominal or chest pain, joint pains and swelling. The disease generally affects people of Mediterranean and Middle Eastern descent,COMMON AREA
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PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALSABOUTPROJECTSPUBLICATIONSNEWSCONTACTSMEMBER AREA The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisation studies in children with paediatric rheumatic diseases. INFORMATION ON PAEDIATRIC RHEUMATIC DISEASESPOLSKA POLANDMEXICOSOUTH AFRICASLOVENSKO SLOVAKIAITALIA ITALYECUADOR Information on Paediatric Rheumatic Diseases. PRES recommendations in the corona era- COVID-19. 1. Be updated and follow the individual country’s Ministry of Health/National public health care body’s recommendations. 2. Ensure you meticulously follow all hygiene recommendations. Please note that the newcoronavirus may remain viablefor hour
INFORMATION ON PAEDIATRIC RHEUMATIC DISEASES 3. At the moment for children with rheumatic diseases on medication, we recommend to continue all therapies as usual. 4. Don’t stop your medications including methotrexate (MTX) and biologics, without consulting your rheumatologist. This may cause a flare of your rheumatic disease. 5.EUROFEVER PROJECT
A diagnostic Flow-chart for children with suspected monogenic Periodic Fever The Diagnostic score and the diagnostic flow chart (see the Figure) are aimed to provide an evidence-based tool to General Pediatricians that usually observe for the first time children with periodic fevers. Its aim is to timely select those patients at higher risk to carry mutations of known genes.DRUG THERAPY
A 4 to 6 week trial of a single NSAID is necessary to assess its efficacy. However, since NSAIDs are not disease-modifying drugs (i.e. they are not able to modify the course of the disease), they are used more to treat pain, stiffness and fever associated with systemicarthritis.
AUTOINFLAMMATORY DISEASES 1. GENERAL INTRODUCTION TO AUTOINFLAMMATORY DISEASES. 1.1 General introduction. Recent progress in research has clearly shown that some rare fever diseases are caused by genetic defects. In some of diseases there may be several members of a single family who suffer fromrecurrent fevers.
JUVENILE DERMATOMYOSITIS Juvenile dermatomyositis (JDM) is a rare disease that affects muscles and skin. A disease is defined as "juvenile" when it starts before the age of 16. Juvenile dermatomyositis belongs to a group of conditions that are thought to be autoimmune diseases. Usually the immune system helps us to fight infections. In autoimmune diseases, the immune TNF RECEPTOR ASSOCIATED PERIODIC SYNDROME (TRAPS) TRAPS is an inflammatory disease characterised by recurrent attacks of high spiking fevers, usually of two to three weeks duration. The fever is typically accompanied by gastrointestinal disturbances (abdominal pain, vomiting, diarrhoea), painful red skin rash, muscle pain and swelling around the eyes. Impaired kidney function can be observed JUVENILE IDIOPATHIC ARTHRITIS inflammation occurs after several weeks of therapy. Joint injections Joint injections are used if there are one or more joints with inflammation inhibiting normal movement of the joint and / or are very SYNDROME DE DOULEURS AUX MEMBRES De nombreuses maladies infantiles provoquent des douleurs aux membres. Le nom de Syndrome de Douleurs aux Membres est un terme générique désignant un ensemble de maladies de causes et avec des signes cliniques très différents, mais qui ont en commun la présence de douleurs aux membres en continu ou par intermittence. PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALSABOUTPROJECTSPUBLICATIONSNEWSCONTACTSMEMBER AREA The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisation studies in children with paediatric rheumatic diseases. INFORMATION ON PAEDIATRIC RHEUMATIC DISEASESPOLSKA POLANDMEXICOSOUTH AFRICASLOVENSKO SLOVAKIAITALIA ITALYECUADOR Information on Paediatric Rheumatic Diseases. PRES recommendations in the corona era- COVID-19. 1. Be updated and follow the individual country’s Ministry of Health/National public health care body’s recommendations. 2. Ensure you meticulously follow all hygiene recommendations. Please note that the newcoronavirus may remain viablefor hour
INFORMATION ON PAEDIATRIC RHEUMATIC DISEASES 3. At the moment for children with rheumatic diseases on medication, we recommend to continue all therapies as usual. 4. Don’t stop your medications including methotrexate (MTX) and biologics, without consulting your rheumatologist. This may cause a flare of your rheumatic disease. 5.EUROFEVER PROJECT
A diagnostic Flow-chart for children with suspected monogenic Periodic Fever The Diagnostic score and the diagnostic flow chart (see the Figure) are aimed to provide an evidence-based tool to General Pediatricians that usually observe for the first time children with periodic fevers. Its aim is to timely select those patients at higher risk to carry mutations of known genes.DRUG THERAPY
A 4 to 6 week trial of a single NSAID is necessary to assess its efficacy. However, since NSAIDs are not disease-modifying drugs (i.e. they are not able to modify the course of the disease), they are used more to treat pain, stiffness and fever associated with systemicarthritis.
AUTOINFLAMMATORY DISEASES 1. GENERAL INTRODUCTION TO AUTOINFLAMMATORY DISEASES. 1.1 General introduction. Recent progress in research has clearly shown that some rare fever diseases are caused by genetic defects. In some of diseases there may be several members of a single family who suffer fromrecurrent fevers.
JUVENILE DERMATOMYOSITIS Juvenile dermatomyositis (JDM) is a rare disease that affects muscles and skin. A disease is defined as "juvenile" when it starts before the age of 16. Juvenile dermatomyositis belongs to a group of conditions that are thought to be autoimmune diseases. Usually the immune system helps us to fight infections. In autoimmune diseases, the immune TNF RECEPTOR ASSOCIATED PERIODIC SYNDROME (TRAPS) TRAPS is an inflammatory disease characterised by recurrent attacks of high spiking fevers, usually of two to three weeks duration. The fever is typically accompanied by gastrointestinal disturbances (abdominal pain, vomiting, diarrhoea), painful red skin rash, muscle pain and swelling around the eyes. Impaired kidney function can be observed JUVENILE IDIOPATHIC ARTHRITIS inflammation occurs after several weeks of therapy. Joint injections Joint injections are used if there are one or more joints with inflammation inhibiting normal movement of the joint and / or are very SYNDROME DE DOULEURS AUX MEMBRES De nombreuses maladies infantiles provoquent des douleurs aux membres. Le nom de Syndrome de Douleurs aux Membres est un terme générique désignant un ensemble de maladies de causes et avec des signes cliniques très différents, mais qui ont en commun la présence de douleurs aux membres en continu ou par intermittence. PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALS The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisation PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALS The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisation PAEDIATRIC RHEUMATIC DISEASES Version of 2016. Juvenile Idiopathic Arthritis. Systemic Lupus Erythematosus. Antiphospholipid antibodies, Neonatal lupus. Juvenile Dermatomyositis. Scleroderma. Juvenile Spondyloarthritis / Enthesitis Related Arthritis (SpA-ERA)BEHCET’S DISEASE
Behçet’s syndrome, or Behçet’s disease (BD), is a chronic inflammatory condition of unknown cause that leads to inflammation of blood vessels throughout the body (systemic vasculitis).The mucosa (tissue that produces mucous, which is found in the lining of the digestive, genital and urinary organs) and skin are affected and the main symptoms are recurrent oral and genital ulcers and eye JUVENILE IDIOPATHIC ARTHRITIS Juvenile idiopathic arthritis (JIA) is a chronic disease characterised by persistent joint inflammation; the typical signs of joint inflammation are pain, swelling and limitation of movement. evidence-based. consensus opinion. 2016. JUVENILE SPONDYLOARTHRITIS / ENTHESITIS RELATED ARTHRITIS Juvenile SpA-ERA constitutes a group of chronic inflammatory diseases of the joints (arthritis), as well as tendon and ligament attachments to certain bones (enthesitis) and affects predominantly the lower limbs and in some cases the pelvic and spinal joints (sacroiliitis - buttock pain and spondylitis - back pain). SYNDROME DE DOULEURS AUX MEMBRES La fibromyalgie appartient au groupe « syndrome douloureux musculo-squelettique amplifié ». La fibromyalgie est un syndrome caractérisé par des douleurs musculo-squelettiques étendues à long terme au niveau des membres supérieurs et inférieurs ainsi qu'au niveau du dos, de l'abdomen, de la poitrine, du cou et/ou des mâchoires pendant au moins 3 mois, associées à de la fatigue, unEUROFEVER PROJECT
The Eurofever project includes the following actions: a survey on the prevalence of diagnosed or suspected autoinflammatory diseases among all European Paediatric Rheumatology Centers. an international Registry for Autoinflammatory diseases. a survey on the efficacy of treatment in these disorders. elaboration of outcome measures forpossible
ARTHRITE DE LYME
1.1 Qu'est-ce que c'est ? L'arthrite de Lyme est une des maladies provoquées par la bactérie Borrelia burgdorferi (borréliose de Lyme), qui est transmise par des piqûres de tiques, dont l'Ixodes ricinus. Alors que l'infection à Borrelia burgdorferi touche la peau, le système nerveux central, le cœur, les yeux et d'autres organes,les
若年性皮膚筋炎 若年性皮膚筋炎(JDM)は筋肉と皮膚が冒される珍しい病気です。. 16歳以前に発症したものを「若年性」といいます。. 若年性皮膚筋炎は自己免疫疾患の一つです。. 普通 免疫系は私たちを感染症から守ってくれます。. ところが 自己免疫疾患では 異常な免疫 INFORMATION ON PAEDIATRIC RHEUMATIC DISEASESPOLSKA POLANDMEXICOSOUTH AFRICASLOVENSKO SLOVAKIAITALIA ITALYECUADOR Information on Paediatric Rheumatic Diseases. PRES recommendations in the corona era- COVID-19. 1. Be updated and follow the individual country’s Ministry of Health/National public health care body’s recommendations. 2. Ensure you meticulously follow all hygiene recommendations. Please note that the newcoronavirus may remain viablefor hour
INFORMATION ON PAEDIATRIC RHEUMATIC DISEASES 3. At the moment for children with rheumatic diseases on medication, we recommend to continue all therapies as usual. 4. Don’t stop your medications including methotrexate (MTX) and biologics, without consulting your rheumatologist. This may cause a flare of your rheumatic disease. 5.EUROFEVER PROJECT
A diagnostic Flow-chart for children with suspected monogenic Periodic Fever The Diagnostic score and the diagnostic flow chart (see the Figure) are aimed to provide an evidence-based tool to General Pediatricians that usually observe for the first time children with periodic fevers. Its aim is to timely select those patients at higher risk to carry mutations of known genes. PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALS The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisationDRUG THERAPY
A 4 to 6 week trial of a single NSAID is necessary to assess its efficacy. However, since NSAIDs are not disease-modifying drugs (i.e. they are not able to modify the course of the disease), they are used more to treat pain, stiffness and fever associated with systemicarthritis.
JUVENILE DERMATOMYOSITIS Juvenile dermatomyositis (JDM) is a rare disease that affects muscles and skin. A disease is defined as "juvenile" when it starts before the age of 16. Juvenile dermatomyositis belongs to a group of conditions that are thought to be autoimmune diseases. Usually the immune system helps us to fight infections. In autoimmune diseases, the immune AUTOINFLAMMATORY DISEASES 1. GENERAL INTRODUCTION TO AUTOINFLAMMATORY DISEASES. 1.1 General introduction. Recent progress in research has clearly shown that some rare fever diseases are caused by genetic defects. In some of diseases there may be several members of a single family who suffer fromrecurrent fevers.
EUROFEVER PROJECT
Why do we need a Registry for Autoinflammatory diseases? The main limitation to a better knowledge of these rare conditions is related to the extreme fragmentation of the diagnosed cases that are spread over different centers and countries.BEHCET’S DISEASE
Behçet’s syndrome, or Behçet’s disease (BD), is a chronic inflammatory condition of unknown cause that leads to inflammation of blood vessels throughout the body (systemic vasculitis).The mucosa (tissue that produces mucous, which is found in the lining of the digestive, genital and urinary organs) and skin are affected and the main symptoms are recurrent oral and genital ulcers and eye TNF RECEPTOR ASSOCIATED PERIODIC SYNDROME (TRAPS) TRAPS is an inflammatory disease characterised by recurrent attacks of high spiking fevers, usually of two to three weeks duration. The fever is typically accompanied by gastrointestinal disturbances (abdominal pain, vomiting, diarrhoea), painful red skin rash, muscle pain and swelling around the eyes. Impaired kidney function can be observed INFORMATION ON PAEDIATRIC RHEUMATIC DISEASESPOLSKA POLANDMEXICOSOUTH AFRICASLOVENSKO SLOVAKIAITALIA ITALYECUADOR Information on Paediatric Rheumatic Diseases. PRES recommendations in the corona era- COVID-19. 1. Be updated and follow the individual country’s Ministry of Health/National public health care body’s recommendations. 2. Ensure you meticulously follow all hygiene recommendations. Please note that the newcoronavirus may remain viablefor hour
INFORMATION ON PAEDIATRIC RHEUMATIC DISEASES 3. At the moment for children with rheumatic diseases on medication, we recommend to continue all therapies as usual. 4. Don’t stop your medications including methotrexate (MTX) and biologics, without consulting your rheumatologist. This may cause a flare of your rheumatic disease. 5.EUROFEVER PROJECT
A diagnostic Flow-chart for children with suspected monogenic Periodic Fever The Diagnostic score and the diagnostic flow chart (see the Figure) are aimed to provide an evidence-based tool to General Pediatricians that usually observe for the first time children with periodic fevers. Its aim is to timely select those patients at higher risk to carry mutations of known genes. PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALS The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisationDRUG THERAPY
A 4 to 6 week trial of a single NSAID is necessary to assess its efficacy. However, since NSAIDs are not disease-modifying drugs (i.e. they are not able to modify the course of the disease), they are used more to treat pain, stiffness and fever associated with systemicarthritis.
JUVENILE DERMATOMYOSITIS Juvenile dermatomyositis (JDM) is a rare disease that affects muscles and skin. A disease is defined as "juvenile" when it starts before the age of 16. Juvenile dermatomyositis belongs to a group of conditions that are thought to be autoimmune diseases. Usually the immune system helps us to fight infections. In autoimmune diseases, the immune AUTOINFLAMMATORY DISEASES 1. GENERAL INTRODUCTION TO AUTOINFLAMMATORY DISEASES. 1.1 General introduction. Recent progress in research has clearly shown that some rare fever diseases are caused by genetic defects. In some of diseases there may be several members of a single family who suffer fromrecurrent fevers.
EUROFEVER PROJECT
Why do we need a Registry for Autoinflammatory diseases? The main limitation to a better knowledge of these rare conditions is related to the extreme fragmentation of the diagnosed cases that are spread over different centers and countries.BEHCET’S DISEASE
Behçet’s syndrome, or Behçet’s disease (BD), is a chronic inflammatory condition of unknown cause that leads to inflammation of blood vessels throughout the body (systemic vasculitis).The mucosa (tissue that produces mucous, which is found in the lining of the digestive, genital and urinary organs) and skin are affected and the main symptoms are recurrent oral and genital ulcers and eye TNF RECEPTOR ASSOCIATED PERIODIC SYNDROME (TRAPS) TRAPS is an inflammatory disease characterised by recurrent attacks of high spiking fevers, usually of two to three weeks duration. The fever is typically accompanied by gastrointestinal disturbances (abdominal pain, vomiting, diarrhoea), painful red skin rash, muscle pain and swelling around the eyes. Impaired kidney function can be observed PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALS The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisation AUTOINFLAMMATORY DISEASES 1. GENERAL INTRODUCTION TO AUTOINFLAMMATORY DISEASES. 1.1 General introduction. Recent progress in research has clearly shown that some rare fever diseases are caused by genetic defects. In some of diseases there may be several members of a single family who suffer fromrecurrent fevers.
PRINTO - PAEDIATRIC RHEUMATOLOGY INTERNATIONAL TRIALS The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a non governmental international network with the goal to facilitate and co-ordinate the development, of multi-centres, international clinical trials and/or outcome standardisation JUVENILE IDIOPATHIC ARTHRITIS Juvenile idiopathic arthritis (JIA) is a chronic disease characterised by persistent joint inflammation; the typical signs of joint inflammation are pain, swelling and limitation of movement. evidence-based. consensus opinion. 2016.EUROFEVER PROJECT
The Eurofever project includes the following actions: a survey on the prevalence of diagnosed or suspected autoinflammatory diseases among all European Paediatric Rheumatology Centers. an international Registry for Autoinflammatory diseases. a survey on the efficacy of treatment in these disorders. elaboration of outcome measures forpossible
FAMILIAL MEDITERRANEAN FEVER Familial Mediterranean Fever (FMF) is a genetically transmitted disease. Patients suffer from recurrent bouts of fever, accompanied by abdominal or chest pain, joint pains and swelling. The disease generally affects people of Mediterranean and Middle Eastern descent, SYSTEMIC LUPUS ERYTHEMATOSUS Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect various organs of the body, especially the skin, joints, blood, kidneys and central nervous system. "Chronic" means that it can last for a long time. "Autoimmune" means that there is a disorder of the immune system, which, instead of protecting the bodyfrom
JUVENILE SPONDYLOARTHRITIS / ENTHESITIS RELATED ARTHRITIS As mentioned above, juvenile spondyloarthritis is the name for a group of diseases; the clinical features may overlap with each other, including axial and peripheral spondyloarthritis, ankylosing spondylitis, undifferentiated spondyloarthritis, psoriatic arthritis, reactive arthritis and arthritis associated with Crohn’s disease andulcerative colitis.
JUVENILE IDIOPATHIC ARTHRITIS inflammation occurs after several weeks of therapy. Joint injections Joint injections are used if there are one or more joints with inflammation inhibiting normal movement of the joint and / or are very 若年性皮膚筋炎 若年性皮膚筋炎(JDM)は筋肉と皮膚が冒される珍しい病気です。. 16歳以前に発症したものを「若年性」といいます。. 若年性皮膚筋炎は自己免疫疾患の一つです。. 普通 免疫系は私たちを感染症から守ってくれます。. ところが 自己免疫疾患では 異常な免疫Toggle navigation
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PRINTO
The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a not for profit, non governmental, international research network founded by Alberto Martini and Nicolino Ruperto in 1996. The coordinating centre is based in Genoa. PRINTO initially included 14 European countries (about 93 countries, 688 centres worldwide with 1536 members today), with the goal to foster, facilitate and co-ordinate the development, conduct, analysis, and reporting of multi-centres, international clinical trials and/or outcome standardisation studies in children with paediatric rheumatic diseases (PRD).Via Gaslini, 5
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Genoa 2019
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Pavia 1996
Pavia 2001
The Paediatric Rheumatology INternational Trials Organisation (PRINTO) is a not for profit, non governmental, international research network founded by Alberto Martini and Nicolino Ruperto in 1996. PRINTO initially included 14 European countries (about 93 countries, 688 centres worldwide with 1536 members today), with the goal to foster, facilitate and co-ordinate the development, conduct, analysis, and reporting of multi-centres, international clinical trials and/or outcome standardisation studies in children with paediatric rheumaticdiseases (PRD).
The coordinating centre is based inGenoa.
To learn more about PRINTO click here To download the PRINTO brochure click hereIN THE SPOTLIGHT
* 17-NOV-2020
PReS/PRINTO Research Grant - 2020 Call for Applications is open |Deadline ...
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* 17-SEP-2020
PRINTO General Assembly at PReS 2020More details...
* 27-FEB-2020
EVENT CANCELLED! PRINTO Paediatric Rheumatology Day for AlbertoMartini | 2...
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* 15-MAR-2019
EPOCA manuscript published in Lancet Child Adolesc Health!Paper details...
* 04-FEB-2019
First results of the PRINTO Consensus for new JIA Classificationpublished!
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* 27-DEC-2018
Pharmacovigilance in JIA: Pharmachild manuscript published in ART!Paper details...
* 16-AUG-2018
Consensus proposal for Taxonomy of AIDs: manuscript published on ARDPaper details...
* 24-MAY-2018
Subcutaneous Abatacept in poly JIA Manuscript published in Arthritis &Rheu...
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* 03-MAY-2018
Genoa will host the 2019 Meeting of the International Society ofSystemic A...
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* 23-APR-2018
Results of an international delphi survey for the definition of thevariabl...
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PROJECTS
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CONECT4CHILDREN (C4C) PRINTO is partner of the "conect4children" (c4c) initiative, the collaborative network for European clinical trials for children, (c4c) a consortium that aims to enhance the competitiveness of Europe as a critical region for developing medicines for children.Learn More
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LIAISONS WITH PHARMACEUTICAL COMPANIES PRINTO is working with pharmaceutical companies as advisor for trials planning, centre selection, data collection, data analysis andinterpretation…
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THE STARS TRIAL
The comparison of STep-up and step-down therapeutic strategies in childhood ARthritiS trial (STARS) is a new interventional trial aiming to investigate whether an early aggressive therapeutic intervention in children with JIA, based on the initial start of synthetic and biologic DMARDs (Step-down strategy), is superior to an approach based on treatment escalation conducted following the treat-to-target principle (Step-up strategy).Learn More
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THE JIA CLASSIFICATION STUDY The PRINTO Evidence-based Revision of the International League Against Rheumatism (ILAR) Classification criteria for juvenile idiopathicArthritis.
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The PReS Autoinflammatory Diseases’ Working Group, in collaboration with PRINTO, set up a a web-based international registry for Autoinflammatory diseases.Learn More
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CROSS-CULTURAL ADAPTATION AND VALIDATION OF LOSQI IN JLS Cross-cultural adaptation and validation of the Localised Scleroderma Quality of Life Instrument (LoSQI) in juvenile localised scleroderma (JLS) is a multicentre study of the PRES scleroderma working party in collaboration with members of the CARRA scleroderma working group.Learn More
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PRINTO and PRES are conducting a pharmacovigilance project which aims at observing children with JIA for 3-10 years undergoing treatment with MTX or biologic agents in order to collect moderate, severe or serious adverse events occurred.Learn More
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THE HYPERPED-COVID REGISTRY A joined PReS, ESID, ISSAID, ERN-RITA and PRINTO network’s effort has been started with the aim to buid a registry of children and young adults who have developed serious inflammatory condition in temporal association with COVID-19 in the community.Learn More
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THE DAISY STUDY
The DAISY study (Applicability of standardized ultrasound examination to estimate disease activity in combination with JADAS and inflammation markers in JIA patients) aims to investigate sensitivity and predictive value of the multi-biomarker panel and to evaluate if it could be applied in limited number of joints in patients with oligo and polyarticular JIA course as a new disease activity tool andoutcome measure.
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CERTIFICATIONS
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IRCCS Istituto G. Gaslini , Universita' diGenova
Clinica Pediatrica e Reumatologia, EULAR Centre of Excellence in Rheumatology 2008-2023 Via Gaslini, 5 16147 Genova, Italy__ www.printo.it
__ Website for families__ 0039-010382854
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__ PRINTO
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