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PACIFIC BIOSCIENCES ANNOUNCES $900 MILLION INVESTMENT FROM MENLO PARK, Calif., Feb. 10, 2021 (GLOBE NEWSWIRE) — Pacific Biosciences of California, Inc. (NASDAQ: PACB) (the “Company”), a leading provider of high-quality, long-read sequencing platforms, today announced that SB Management, a subsidiary of Softbank Group Corp., will make an investment of $900 million in convertible senior notes to support the Company’s future growth initiatives. ILLUMINA AND PACIFIC BIOSCIENCES ANNOUNCE TERMINATION OF SAN DIEGO & MENLO PARK, Calif. –(BUSINESS WIRE)–Jan. 2, 2020– Illumina, Inc. (NASDAQ:ILMN) and Pacific Biosciences of California, Inc. (NASDAQ:PACB) today announced that they have mutually agreed to terminate their merger agreement, previously announced on November 1, 2018, under which Illumina would acquire Pacific Biosciences at a fully diluted enterprise value of approximately $1.2SOFTWARE DOWNLOADS
PacBio’s open-source SMRT Analysis software suite is designed for use with Single Molecule, Real-Time (SMRT) Sequencing data. You can analyze, visualize, and manage your data through an intuitive GUI or command-line interface. SAMPLE AND TEMPLATE PREPARATION KITS The Barcoded Adapter Kit- 8A contains 8 blunt ended barcoded adapters and Sequencing Primer v4. Each tube of Barcoded Adapter contains sufficient reagents to perform 6 ligation reactions. The specific barcodes contained in this kit are: bc1001, SMRT CELLS, SEQUENCING REAGENT KITS, AND ACCESSORIES By downloading, copying, or making any use of the images located on this website (“Site”) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below.SMRT GRANTS
By downloading, copying, or making any use of the images located on this website (“Site”) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below. SMRT LEIDEN 2021 YOUNG INVESTIGATOR VIRTUAL CONFERENCE The SMRT Leiden 2021 – Young Investigator Virtual Conference includes two back-to-back events: the 6 th annual SMRT Scientific Symposium and the SMRT Informatics Developers Meeting.. This year SMRT Leiden will put the spotlight on young investigators who will share their latest scientific discoveries and novel analytical achievements using PacBio long-read sequencing. TEMPLATE PREPARATION KITS By downloading, copying, or making any use of the images located on this website (“Site”) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below. GUIDE - PACIFIC BIOSCIENCES TEMPLATE PREPARATION AND System includes the Instrument, the accompanying kits needed for DNA template preparation and sequencing on the instru-ment, and the software used to set up runs and analyze data. SEQUENCE WITH CONFIDENCE PacBio highly accurate long-read sequencing provides the most comprehensive view of genomes, transcriptomes, and epigenomes. Learn how SMRT Sequencing powers genomic insights in humans, plants, animalsand microbes.
PACIFIC BIOSCIENCES ANNOUNCES $900 MILLION INVESTMENT FROM MENLO PARK, Calif., Feb. 10, 2021 (GLOBE NEWSWIRE) — Pacific Biosciences of California, Inc. (NASDAQ: PACB) (the “Company”), a leading provider of high-quality, long-read sequencing platforms, today announced that SB Management, a subsidiary of Softbank Group Corp., will make an investment of $900 million in convertible senior notes to support the Company’s future growth initiatives. ILLUMINA AND PACIFIC BIOSCIENCES ANNOUNCE TERMINATION OF SAN DIEGO & MENLO PARK, Calif. –(BUSINESS WIRE)–Jan. 2, 2020– Illumina, Inc. (NASDAQ:ILMN) and Pacific Biosciences of California, Inc. (NASDAQ:PACB) today announced that they have mutually agreed to terminate their merger agreement, previously announced on November 1, 2018, under which Illumina would acquire Pacific Biosciences at a fully diluted enterprise value of approximately $1.2SOFTWARE DOWNLOADS
PacBio’s open-source SMRT Analysis software suite is designed for use with Single Molecule, Real-Time (SMRT) Sequencing data. You can analyze, visualize, and manage your data through an intuitive GUI or command-line interface. SAMPLE AND TEMPLATE PREPARATION KITS The Barcoded Adapter Kit- 8A contains 8 blunt ended barcoded adapters and Sequencing Primer v4. Each tube of Barcoded Adapter contains sufficient reagents to perform 6 ligation reactions. The specific barcodes contained in this kit are: bc1001, SMRT CELLS, SEQUENCING REAGENT KITS, AND ACCESSORIES By downloading, copying, or making any use of the images located on this website (“Site”) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below.SMRT GRANTS
By downloading, copying, or making any use of the images located on this website (“Site”) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below. SMRT LEIDEN 2021 YOUNG INVESTIGATOR VIRTUAL CONFERENCE The SMRT Leiden 2021 – Young Investigator Virtual Conference includes two back-to-back events: the 6 th annual SMRT Scientific Symposium and the SMRT Informatics Developers Meeting.. This year SMRT Leiden will put the spotlight on young investigators who will share their latest scientific discoveries and novel analytical achievements using PacBio long-read sequencing. TEMPLATE PREPARATION KITS By downloading, copying, or making any use of the images located on this website (“Site”) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below. GUIDE - PACIFIC BIOSCIENCES TEMPLATE PREPARATION AND System includes the Instrument, the accompanying kits needed for DNA template preparation and sequencing on the instru-ment, and the software used to set up runs and analyze data.SOFTWARE DOWNLOADS
PacBio’s open-source SMRT Analysis software suite is designed for use with Single Molecule, Real-Time (SMRT) Sequencing data. You can analyze, visualize, and manage your data through an intuitive GUI or command-line interface. PACIFIC BIOSCIENCES WELCOMES NEIL WARD TO ITS LEADERSHIP Industry Veteran Will Lead PacBio’s Commercial Footprint Across the Region. MENLO PARK, Calif., June 08, 2021 (GLOBE NEWSWIRE) — Pacific Biosciences of California, Inc. (Nasdaq: PACB), a leading provider of high-quality, long-read sequencing platforms, today welcomed Neil Ward to the new role of Vice President and General Manager for the company’s Europe, Middle East, and Africa (EMEASMRT GRANTS
By downloading, copying, or making any use of the images located on this website (“Site”) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below. PACIFIC BIOSCIENCES FURTHER EXPANDS LEADERSHIP TEAM WITH Kathleen Lynch has joined as Head of Global Government Affairs and Communications and Michele Farmer has joined as Chief Accounting Officer. MENLO PARK, Calif., May 17, 2021 (GLOBE NEWSWIRE) — Pacific Biosciences of California, Inc. (Nasdaq: PACB), a leading provider of high-quality, long-read sequencing platforms, today announced the appointment of three new hires to its growing REACHING A GENOMICS MILESTONE This tremendous effort incorporated several cutting-edge technologies, including HiFi sequencing from PacBio, to produce a gap-free, complete haploid human genome assembly based on a complete hydatidiform mole (CHM13). The goal was to create a novel resource with comprehensive, reliable genome data that avoids the gaps and errors that still mark the latest GRCh38 reference TUTORIAL: CIRCULAR CONSENSUS SEQUENCE ANALYSIS APPLICATION By downloading, copying, or making any use of the images located on this website (“Site”) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below. DIRECT DETECTION OF DNA METHYLATION DURING SINGLE-MOLECULE We describe the direct detection of DNA methylation, without bisulfite conversion, through single-molecule, real-time (SMRT) sequencing. In SMRT sequencing, DNA polymerases catalyze the incorporation of fluorescently labeled nucleotides into complementary nucleic acid strands. The arrival times and durations of the resulting fluorescence pulses yield information about polymerase kinetics EXTRACTING DNA USING PHENOL-CHLOROFORM 10. Add equal volumes of the chloroform/isoamyl alcohol solution to TUBE 2. 11. Vortex TUBE 2 vigorously for 1 minute. 12. TUBE 2Spin solution at high speed for 5 minutes. 13. Remove as much of the top aqueous solution as possible and place into a new tube, TUBE 3.Avoid ISO-SEQ METHOD AND ANALYSIS RNA SAMPLE QUALITY REQUIREMENTS For optimal sequencing performance, it is essential that the RNA sample:-Has not undergone multiple freeze‐thaw cycles as they can lead to RNA degradation.-Has not been exposed to high temperatures or pH extremes (9).For example, exposure to 70°C for >10 min or pH >8.5 will cause degradation. PACIFIC BIOSCIENCES GLOSSARY OF TERMS Page 3 • productivity: A measure of the reads from a ZMW. P=1 means that there is a polymerase read from that ZMW. P=0 means that a ZMW did not produce a read and is presumed to be lacking a polymerase. P=2 means “other” and the signal collected from the ZMW was notconducive to
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Pacific Biosciences is committed to providing high-quality products that meet customer expectations and comply with regulations. We will achieve these goals by adhering to and maintaining an effective quality-management system designed to ensure product quality, performance, and safety.X
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By downloading, copying, or making any use of the images located on this website (“Site”) you acknowledge that you have read and understand, and agree to, the terms of this Image Usage Agreement, as well as the terms provided on the Legal Notices webpage, which together govern your use of the images as provided below. If you do not agree to such terms, do not download, copy or use the images in any way, unless you have written permission signed by an authorized Pacific Biosciences representative. Subject to the terms of this Agreement and the terms provided on the Legal Notices webpage (to the extent they do not conflict with the terms of this Agreement), you may use the images on the Site solely for (a) editorial use by press and/or industry analysts, (b) in connection with a normal, peer-reviewed, scientific publication, book or presentation, or the like. You may not alter or modify any image, in whole or in part, for any reason. You may not use any image in a manner that misrepresents the associated Pacific Biosciences product, service or technology or any associated characteristics, data, or properties thereof. You also may not use any image in a manner that denotes some representation or warranty (express, implied or statutory) from Pacific Biosciences of the product, service or technology. The rights granted by this Agreement are personal to you and are not transferable by you to another party. You, and not Pacific Biosciences, are responsible for your use of the images. You acknowledge and agree that any misuse of the images or breach of this Agreement will cause Pacific Biosciences irreparable harm. Pacific Biosciences is either an owner or licensee of the image, and not an agent for the owner. You agree to give Pacific Biosciences a credit line as follows: "Courtesy of Pacific Biosciences of California, Inc., Menlo Park, CA, USA" and also include any other credits or acknowledgments noted by Pacific Biosciences. You must include any copyright notice originally included with the images onall copies.
IMAGES ARE PROVIDED BY Pacific Biosciences ON AN "AS-IS" BASIS. Pacific Biosciences DISCLAIMS ALL REPRESENTATIONS AND WARRANTIES, EXPRESS, IMPLIED OR STATUTORY, INCLUDING, BUT NOT LIMITED TO, NON-INFRINGEMENT, OWNERSHIP, MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. IN NO EVENT SHALL Pacific Biosciences BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, PUNITIVE, OR CONSEQUENTIAL DAMAGES OF ANY KIND WHATSOEVER WITH RESPECT TO THE IMAGES. You agree that Pacific Biosciences may terminate your access to and use of the images located on the PacificBiosciences.com website at any time and without prior notice, if it considers you to have violated any of the terms of this Image Use Agreement. You agree to indemnify, defend and hold harmless Pacific Biosciences, its officers, directors, employees, agents, licensors, suppliers and any third party information providers to the Site from and against all losses, expenses, damages and costs, including reasonable attorneys' fees, resulting from any violation by you of the terms of this Image Use Agreement or Pacific Biosciences' termination of your access to or use of the Site. Termination will not affect Pacific Biosciences' rights or your obligations which accrued before the termination. I have read and understand, and agree to, the Image Usage Agreement. I disagree and would like to return to the Pacific Biosciences homepage.
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* Products + Services With innovations in sequencing and data analysis tools, PacBio offers the most advanced suite of products and services available. * PacBio Sequel Systems* Consumables
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PacBio’s Single Molecule, Real-Time (SMRT) Sequencing offers the most comprehensive view of genomes for a wide range of research areas. * Human Biomedical Research * Plant and Animal Sciences * Microbiology and Infectious Disease* Applications
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HiFi reads allow the accurate and simultaneous detection of single nucleotide and structural variants, paving the way for advancements in human genetics and greatly expanding the utility of SMRT Sequencing. Generating HiFi reads directly on the Sequel IIe System now has the potential to further accelerate cost-effective access to this information-rich sequencing data. – FRITZ SEDLAZECK, PH.D., ASSISTANT PROFESSOR, HUMAN GENOME SEQUENCING CENTER AT BAYLOR COLLEGE OF MEDICINE My sequencing center has seen the level of interest in projects to be run on our Sequel II System increase by over 100% this year, as compared to the previous year. Many of these projects are coming from investigators and collaborators that are new to my center, they are interested in using HiFi sequencing in their research. – BRUCE KINGHAM, DIRECTOR, SEQUENCING AND GENOTYPING, UNIVERSITY OFDELAWARE
The Oxford Genomics Centre, the Core Facility of the Wellcome Centre for Human Genetics, is excited to invest in Pacific Biosciences' Sequel IIe, introducing their highly-accurate long-read sequencing to Oxford and beyond. This advance will drive new developments in analyses from whole viral sequences to complete assemblies of complex structural regions of the human genome and their epigeneticfootprints.
– PROF JOHN TODD, CENTRE DIRECTOR & DR DAVID BUCK, HEAD OF HIGH THROUGHPUT GENOMICS, OXFORD GENOMICS CENTRE, WELLCOME TRUST CENTRE FORHUMAN GENETICS
It's amazing to see lower-cost human genome sequences coming from the Sequel II System approaching the quality and completeness of the human reference genome, which took billions of dollars and many years toproduce.
– JEREMY SCHMUTZ, FACULTY INVESTIGATOR, HUDSONALPHA INSTITUTE OFBIOTECHNOLOGY
PacBio sets the standard for long-read sequencing and this upgrade of their instrument should have high impact on genomics sciences. – H. STEVEN WILEY, JUDGE FOR _THE SCIENTIST_ 2019 TOP 10INNOVATIONS AWARDS
SEQUENCE WITH CONFIDENCE USING PACBIO HIGHLY ACCURATE LONG READS Explore the advantages of the Sequel II and IIe Systems and SMRT Sequencing technology DISCOVER THE BENEFITS FOR YOUR RESEARCH FOCUSHUMAN BIOMEDICAL
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Better Apple Pies: HiFi Reads are a Perfect Recipe for High-Quality Apple Genome and Pangenome...In the News
Boyce Thompson Institute: Tomato’s Wild Ancestor Is a Genomic Reservoir for Plant BreedersPublication
Genes: Phased Haplotype Resolution of the SLC6A4 Promoter Using Long-Read Single Molecule Real-Time...Blog
Scientists Pinpoint Pathogenic Inversion in Intellectual Disability Case Using HiFi SequencingIn the News
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