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ISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of SOTORASIB FOR LUNG CANCERS WITH KRAS P.G12C MUTATION ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2SEE MORE ONNEJM.ORG
PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a MONOCLONAL GAMMOPATHY OF RENAL SIGNIFICANCE Monoclonal Gammopathy of Renal Significance Monoclonal gammopathy of renal significance is a B-cell or plasma-cell clonal disorder that does not meet the criteria for cancer but produces a monoclon ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR3 Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZEDSEE MORE ONNEJM.ORG
TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERESEE MORE ON NEJM.ORG VADADUSTAT IN PATIENTS WITH ANEMIA AND NON–DIALYSISSEE MORE ONNEJM.ORG
PERIOPERATIVE BRIDGING ANTICOAGULATION IN PATIENTS WITH n engl j med 373;9 nejm.org August 27, 2015 825 Bridging Anticoagulation in Patients with Atrial Fibrillation Produce res Patients were randomly assigned to receive THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of SOTORASIB FOR LUNG CANCERS WITH KRAS P.G12C MUTATION ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2SEE MORE ONNEJM.ORG
PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a MONOCLONAL GAMMOPATHY OF RENAL SIGNIFICANCE Monoclonal Gammopathy of Renal Significance Monoclonal gammopathy of renal significance is a B-cell or plasma-cell clonal disorder that does not meet the criteria for cancer but produces a monoclon ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR3 Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZEDSEE MORE ONNEJM.ORG
TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERESEE MORE ON NEJM.ORG VADADUSTAT IN PATIENTS WITH ANEMIA AND NON–DIALYSISSEE MORE ONNEJM.ORG
PERIOPERATIVE BRIDGING ANTICOAGULATION IN PATIENTS WITH n engl j med 373;9 nejm.org August 27, 2015 825 Bridging Anticoagulation in Patients with Atrial Fibrillation Produce res Patients were randomly assigned to receive VACCINE BREAKTHROUGH INFECTIONS WITH SARS-COV-2 VARIANTS This letter was published on June 2, 2021, at NEJM.org. 1. Hacisuleyman E, Hale C, Saito Y, et al. Vaccine breakthrough infections with SARS-CoV-2 variants. N Engl J Med. DOI: 10.1056 PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a MAINTAINING SAFETY WITH SARS-COV-2 VACCINES 644 n engl j med 384;7 nejm.org February 18, 2021 The new england journal of medicine issued a pause on vaccination with the Pfizer– BioNTech SARS-CoV-2 mRNA vaccine, to exclude any person with FACIAL MASKING FOR COVID-19 Saskia V. Popescu, Ph.D. George Mason University, Arlington, VA. No potential conflict of interest relevant to this letter was reported. This letter was published on October 23, 2020, at NEJM.orgΒ-THALASSEMIAS
February 25, 2021. N Engl J Med 2021; 384:727-743. DOI: 10.1056/NEJMra2021838. Editors. Dan L. Longo, M.D., Editor. Defective synthesis of the β-globin chain causes recessively inherited RETHINKING COVID-19 TEST SENSITIVITY PERSPECTIVE e120(3) Rethinking Covid-19 Test Sensitivity n engl j med 383;22 nejm.org november 26, 2020 days, before the virus grows by orders of magnitude, reaching the TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERE Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell–derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of AVACOPAN FOR THE TREATMENT OF ANCA-ASSOCIATED VASCULITIS Methods. In this randomized, controlled trial, we assigned patients with ANCA-associated vasculitis in a 1:1 ratio to receive oral avacopan at a dose of 30 mg twice daily or oral prednisone on a SOTATERCEPT FOR THE TREATMENT OF PULMONARY ARTERIAL In this 24-week multicenter trial, we randomly assigned 106 adults who were receiving background therapy for pulmonary arterial hypertension to receive subcutaneous sotatercept at a dose of 0.3 mgWWW.NEJM.ORG
A 53-year-old man who worked as a gardener presented to the emergency department with sudden onset of paralysis in the lower legs. He had a2-month
THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of SOTORASIB FOR LUNG CANCERS WITH KRAS P.G12C MUTATION ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2SEE MORE ONNEJM.ORG
PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a MONOCLONAL GAMMOPATHY OF RENAL SIGNIFICANCE Monoclonal Gammopathy of Renal Significance Monoclonal gammopathy of renal significance is a B-cell or plasma-cell clonal disorder that does not meet the criteria for cancer but produces a monoclon ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR3 Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZEDSEE MORE ONNEJM.ORG
TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERESEE MORE ON NEJM.ORG VADADUSTAT IN PATIENTS WITH ANEMIA AND NON–DIALYSISSEE MORE ONNEJM.ORG
PERIOPERATIVE BRIDGING ANTICOAGULATION IN PATIENTS WITH n engl j med 373;9 nejm.org August 27, 2015 825 Bridging Anticoagulation in Patients with Atrial Fibrillation Produce res Patients were randomly assigned to receive THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of SOTORASIB FOR LUNG CANCERS WITH KRAS P.G12C MUTATION ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2SEE MORE ONNEJM.ORG
PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a MONOCLONAL GAMMOPATHY OF RENAL SIGNIFICANCE Monoclonal Gammopathy of Renal Significance Monoclonal gammopathy of renal significance is a B-cell or plasma-cell clonal disorder that does not meet the criteria for cancer but produces a monoclon ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR3 Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZEDSEE MORE ONNEJM.ORG
TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERESEE MORE ON NEJM.ORG VADADUSTAT IN PATIENTS WITH ANEMIA AND NON–DIALYSISSEE MORE ONNEJM.ORG
PERIOPERATIVE BRIDGING ANTICOAGULATION IN PATIENTS WITH n engl j med 373;9 nejm.org August 27, 2015 825 Bridging Anticoagulation in Patients with Atrial Fibrillation Produce res Patients were randomly assigned to receive VACCINE BREAKTHROUGH INFECTIONS WITH SARS-COV-2 VARIANTS This letter was published on June 2, 2021, at NEJM.org. 1. Hacisuleyman E, Hale C, Saito Y, et al. Vaccine breakthrough infections with SARS-CoV-2 variants. N Engl J Med. DOI: 10.1056 PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a MAINTAINING SAFETY WITH SARS-COV-2 VACCINES 644 n engl j med 384;7 nejm.org February 18, 2021 The new england journal of medicine issued a pause on vaccination with the Pfizer– BioNTech SARS-CoV-2 mRNA vaccine, to exclude any person with FACIAL MASKING FOR COVID-19 Saskia V. Popescu, Ph.D. George Mason University, Arlington, VA. No potential conflict of interest relevant to this letter was reported. This letter was published on October 23, 2020, at NEJM.orgΒ-THALASSEMIAS
February 25, 2021. N Engl J Med 2021; 384:727-743. DOI: 10.1056/NEJMra2021838. Editors. Dan L. Longo, M.D., Editor. Defective synthesis of the β-globin chain causes recessively inherited RETHINKING COVID-19 TEST SENSITIVITY PERSPECTIVE e120(3) Rethinking Covid-19 Test Sensitivity n engl j med 383;22 nejm.org november 26, 2020 days, before the virus grows by orders of magnitude, reaching the TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERE Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell–derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of AVACOPAN FOR THE TREATMENT OF ANCA-ASSOCIATED VASCULITIS Methods. In this randomized, controlled trial, we assigned patients with ANCA-associated vasculitis in a 1:1 ratio to receive oral avacopan at a dose of 30 mg twice daily or oral prednisone on a SOTATERCEPT FOR THE TREATMENT OF PULMONARY ARTERIAL In this 24-week multicenter trial, we randomly assigned 106 adults who were receiving background therapy for pulmonary arterial hypertension to receive subcutaneous sotatercept at a dose of 0.3 mgWWW.NEJM.ORG
A 53-year-old man who worked as a gardener presented to the emergency department with sudden onset of paralysis in the lower legs. He had a2-month
THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of SOTORASIB FOR LUNG CANCERS WITH KRAS P.G12C MUTATION Sotorasib showed anticancer activity in patients with KRAS p.G12C–mutated advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was observed in DEXAMETHASONE AND SURGICAL-SITE INFECTION PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZEDSEE MORE ONNEJM.ORG
FOUR-MONTH RIFAPENTINE REGIMENS WITH OR WITHOUT We conducted a phase 3 clinical trial to determine whether treatment regimens that included rifapentine, at a once-daily dose of 1200 mg, with or without moxifloxacin, at a once-daily dose of 400 ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of SOTORASIB FOR LUNG CANCERS WITH KRAS P.G12C MUTATION Sotorasib showed anticancer activity in patients with KRAS p.G12C–mutated advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was observed in DEXAMETHASONE AND SURGICAL-SITE INFECTION PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZEDSEE MORE ONNEJM.ORG
FOUR-MONTH RIFAPENTINE REGIMENS WITH OR WITHOUT We conducted a phase 3 clinical trial to determine whether treatment regimens that included rifapentine, at a once-daily dose of 1200 mg, with or without moxifloxacin, at a once-daily dose of 400 ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2 We conducted a phase 3, double-blind, randomized trial involving patients with human epidermal growth factor receptor 2 (HER2)–negative early SOTATERCEPT FOR THE TREATMENT OF PULMONARY ARTERIAL In this 24-week multicenter trial, we randomly assigned 106 adults who were receiving background therapy for pulmonary arterial hypertension to receive subcutaneous sotatercept at a dose of 0.3 mg GLUCOSE-LOWERING DRUGS TO REDUCE CARDIOVASCULAR RISK IN Glucose-Lowering Drugs to Reduce Cardiovascular Risk in Type 2 Diabetes. List of authors. Rita R. Kalyani, M.D. April 1, 2021. N Engl J Med 2021; 384:1248-1260. DOI: 10.1056/NEJMcp2000280. Editors COMPARATIVE EFFECTIVENESS OF ASPIRIN DOSING IN Abstract Background The appropriate dose of aspirin to lower the risk of death, myocardial infarction, and stroke and to minimize major bleeding in patients with TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERE Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell–derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of TYMPANOSTOMY TUBES OR MEDICAL MANAGEMENT FOR RECURRENT Results. In our main, intention-to-treat analysis, the rate (±SE) of episodes of acute otitis media per child-year during a 2-year period was 1.48±0.08 in the tympanostomy-tube group and 1.56±0 LEFT ATRIAL APPENDAGE OCCLUSION DURING CARDIAC SURGERY TO Abstract Background Surgical occlusion of the left atrial appendage has been hypothesized to prevent ischemic stroke in patients with atrial fibrillation, but this has not been proved. The procedur NIVOLUMAB PLUS CABOZANTINIB VERSUS SUNITINIB FOR ADVANCED Nivolumab plus cabozantinib had significant benefits over sunitinib with respect to progression-free survival, overall survival, and likelihood of response in patients with previously untreated A RANDOMIZED TRIAL OF ALBUMIN INFUSIONS IN HOSPITALIZED In patients hospitalized with decompensated cirrhosis, albumin infusions to increase the albumin level to a target of 30 g per liter or more was not more beneficial than the current standard care INHALED TREPROSTINIL IN PULMONARY HYPERTENSION DUE TO In patients with pulmonary hypertension due to interstitial lung disease, inhaled treprostinil improved exercise capacity from baseline, assessed with the use of a 6-minute walk test, as compared THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of PROTECTING OLYMPIC PARTICIPANTS FROM COVID-19 Protecting Olympic Participants from Covid-19 Plans to protect participants and the public from Covid-19 during the Olympics aren’t built on rigorous risk assessment. They fail to consider the TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERESEE MORE ON NEJM.ORG ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2 Conclusions. Among patients with high-risk, HER2-negative early breast cancer and germline BRCA1 or BRCA2 pathogenic or likely pathogenic variants, adjuvant olaparib after completion of FOUR-MONTH RIFAPENTINE REGIMENS WITH OR WITHOUT We conducted a phase 3 clinical trial to determine whether treatment regimens that included rifapentine, at a once-daily dose of 1200 mg, with or without moxifloxacin, at a once-daily dose of 400 ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of PROTECTING OLYMPIC PARTICIPANTS FROM COVID-19 Protecting Olympic Participants from Covid-19 Plans to protect participants and the public from Covid-19 during the Olympics aren’t built on rigorous risk assessment. They fail to consider the TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERESEE MORE ON NEJM.ORG ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2 Conclusions. Among patients with high-risk, HER2-negative early breast cancer and germline BRCA1 or BRCA2 pathogenic or likely pathogenic variants, adjuvant olaparib after completion of FOUR-MONTH RIFAPENTINE REGIMENS WITH OR WITHOUT We conducted a phase 3 clinical trial to determine whether treatment regimens that included rifapentine, at a once-daily dose of 1200 mg, with or without moxifloxacin, at a once-daily dose of 400 ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
PROTECTING OLYMPIC PARTICIPANTS FROM COVID-19 Protecting Olympic Participants from Covid-19 Plans to protect participants and the public from Covid-19 during the Olympics aren’t built on rigorous risk assessment. They fail to consider the WHAT DID I SIGN UP FOR? What Did I Sign Up For? In a city where gun violence was rampant before Covid, bloodshed has only increased with the upheaval of thestructure of
SOTORASIB FOR LUNG CANCERS WITH KRAS P.G12C MUTATION Sotorasib showed anticancer activity in patients with KRAS p.G12C–mutated advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was observed in MAINTAINING SAFETY WITH SARS-COV-2 VACCINES n engl j med 384;7 nejm.org February 18, 2021 645 Maintaining Safety with SARS-Cov-2 Vaccines Nucleus Endoplasmic reticulum Cytosol GolgiPatient-derived
HIPAA AT 25
HIPAA at 25 — A Work in Progress HIPAA is best viewed as a framework of evolving regulation that’s revised periodically in response todemands of
HIDDEN IN PLAIN SIGHT Medicine and Society The new england journal of medicine 874 n engl j med 383;9 nejm.org August 27, 2020 Debra Malina, Ph.D., Editor Hidden in Plain Sight — Reconsidering the Use of Race SUTIMLIMAB IN COLD AGGLUTININ DISEASE Abstract Background Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized AVACOPAN FOR THE TREATMENT OF ANCA-ASSOCIATED VASCULITIS Methods. In this randomized, controlled trial, we assigned patients with ANCA-associated vasculitis in a 1:1 ratio to receive oral avacopan at a dose of 30 mg twice daily or oral prednisone on a ENDOVASCULAR THERAPY FOR STROKE DUE TO BASILAR-ARTERY We randomly assigned patients within 6 hours after the estimated time of onset of a stroke due to basilar-artery occlusion, in a 1:1 ratio, to receive endovascular therapy or standard medical careHIV INFECTION
Key Clinical Points HIV Infection — Screening, Diagnosis, and Treatment Despite extensive knowledge about human immunodeficiency virus (HIV), the number of cases of incident HIV infection THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of PROTECTING OLYMPIC PARTICIPANTS FROM COVID-19 Protecting Olympic Participants from Covid-19 Plans to protect participants and the public from Covid-19 during the Olympics aren’t built on rigorous risk assessment. They fail to consider the TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERESEE MORE ON NEJM.ORG ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2 Conclusions. Among patients with high-risk, HER2-negative early breast cancer and germline BRCA1 or BRCA2 pathogenic or likely pathogenic variants, adjuvant olaparib after completion of FOUR-MONTH RIFAPENTINE REGIMENS WITH OR WITHOUT We conducted a phase 3 clinical trial to determine whether treatment regimens that included rifapentine, at a once-daily dose of 1200 mg, with or without moxifloxacin, at a once-daily dose of 400 ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of PROTECTING OLYMPIC PARTICIPANTS FROM COVID-19 Protecting Olympic Participants from Covid-19 Plans to protect participants and the public from Covid-19 during the Olympics aren’t built on rigorous risk assessment. They fail to consider the TEZEPELUMAB IN ADULTS AND ADOLESCENTS WITH SEVERESEE MORE ON NEJM.ORG ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2 Conclusions. Among patients with high-risk, HER2-negative early breast cancer and germline BRCA1 or BRCA2 pathogenic or likely pathogenic variants, adjuvant olaparib after completion of FOUR-MONTH RIFAPENTINE REGIMENS WITH OR WITHOUT We conducted a phase 3 clinical trial to determine whether treatment regimens that included rifapentine, at a once-daily dose of 1200 mg, with or without moxifloxacin, at a once-daily dose of 400 ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
PROTECTING OLYMPIC PARTICIPANTS FROM COVID-19 Protecting Olympic Participants from Covid-19 Plans to protect participants and the public from Covid-19 during the Olympics aren’t built on rigorous risk assessment. They fail to consider the WHAT DID I SIGN UP FOR? What Did I Sign Up For? In a city where gun violence was rampant before Covid, bloodshed has only increased with the upheaval of thestructure of
SOTORASIB FOR LUNG CANCERS WITH KRAS P.G12C MUTATION Sotorasib showed anticancer activity in patients with KRAS p.G12C–mutated advanced solid tumors in a phase 1 study, and particularly promising anticancer activity was observed in MAINTAINING SAFETY WITH SARS-COV-2 VACCINES n engl j med 384;7 nejm.org February 18, 2021 645 Maintaining Safety with SARS-Cov-2 Vaccines Nucleus Endoplasmic reticulum Cytosol GolgiPatient-derived
HIPAA AT 25
HIPAA at 25 — A Work in Progress HIPAA is best viewed as a framework of evolving regulation that’s revised periodically in response todemands of
HIDDEN IN PLAIN SIGHT Medicine and Society The new england journal of medicine 874 n engl j med 383;9 nejm.org August 27, 2020 Debra Malina, Ph.D., Editor Hidden in Plain Sight — Reconsidering the Use of Race SUTIMLIMAB IN COLD AGGLUTININ DISEASE Abstract Background Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized AVACOPAN FOR THE TREATMENT OF ANCA-ASSOCIATED VASCULITIS Methods. In this randomized, controlled trial, we assigned patients with ANCA-associated vasculitis in a 1:1 ratio to receive oral avacopan at a dose of 30 mg twice daily or oral prednisone on a ENDOVASCULAR THERAPY FOR STROKE DUE TO BASILAR-ARTERY We randomly assigned patients within 6 hours after the estimated time of onset of a stroke due to basilar-artery occlusion, in a 1:1 ratio, to receive endovascular therapy or standard medical careHIV INFECTION
Key Clinical Points HIV Infection — Screening, Diagnosis, and Treatment Despite extensive knowledge about human immunodeficiency virus (HIV), the number of cases of incident HIV infection THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of NEJM WEEKLY CME PROGRAM NEJM automatically tracks your completion of Weekly CME activities through the My Account section of NEJM.org. Certificates for CME record-keeping are available for download, and, where applicable PERSONAL SUBSCRIPTIONS Personal Subscriptions. A subscription to the New England Journal of Medicine (NEJM) — the world’s most respected general medical journal — keeps you current in the rapidly changing field of EDITORS AND PUBLISHERS PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SUTIMLIMAB IN COLD AGGLUTININ DISEASE PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZED Abstract Background Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poorquality of life,
EDITORIAL POLICIES
NEJM KNOWLEDGE+
“NEJM Knowledge+ has been a positive step for our program and reflects our commitment to residents’ success. The powerful thing about NEJM Knowledge+ is the way it can track what residents are working on, how far they have gone, how much time they’re spendingand where they are.
ROTATION PREP
The Art of Leading with the Right Balance as a Senior Resident. Although every resident develops his or her own style for each of these roles, the following practical strategies were discussed in a NEJM Resident 360 discussion (How to Lead a Team on the Wards: The Artto
THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of NEJM WEEKLY CME PROGRAM NEJM automatically tracks your completion of Weekly CME activities through the My Account section of NEJM.org. Certificates for CME record-keeping are available for download, and, where applicable PERSONAL SUBSCRIPTIONS Personal Subscriptions. A subscription to the New England Journal of Medicine (NEJM) — the world’s most respected general medical journal — keeps you current in the rapidly changing field of PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a EDITORS AND PUBLISHERS PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZED Abstract Background Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poorquality of life,
SUTIMLIMAB IN COLD AGGLUTININ DISEASEEDITORIAL POLICIES
NEJM KNOWLEDGE+
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The Art of Leading with the Right Balance as a Senior Resident. Although every resident develops his or her own style for each of these roles, the following practical strategies were discussed in a NEJM Resident 360 discussion (How to Lead a Team on the Wards: The Artto
THE NEW ENGLAND JOURNAL OF MEDICINE: THIS WEEK'S TABLE OF In this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide NEPHROLOGY ARTICLES: THE NEW ENGLAND JOURNAL OF MEDICINE Nephrology. Monoclonal gammopathy of renal significance is a B-cell or plasma-cell clonal disorder that does not meet the criteria for cancer but produces a monoclonal immunoglobulin that leads to NEJM REVIEW CME PROGRAM American Academy of Family Physicians (AAFP) The AAFP has reviewed the NEJM Review CME Program, and deemed it acceptable for AAFP credit.Term
ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2 Recently Published Articles. Sotorasib for Lung Cancers with KRAS p.G12C Mutation F. Skoulidis et al. ; Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer A.N.J. Tutt et ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
LEFT ATRIAL APPENDAGE OCCLUSION DURING CARDIAC SURGERY TO The title of the Visual Abstract is Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke. In a multicenter, randomized, controlled trial involving 4811 adults with a history of ABROCITINIB VERSUS PLACEBO OR DUPILUMAB FOR ATOPIC In this trial, abrocitinib at a dose of either 200 mg or 100 mg once daily resulted in significantly greater reductions in signs and symptoms of moderate-to-severe atopic dermatitis than placebo THE PATHOPHYSIOLOGY OF RACIAL DISPARITIES The Pathophysiology of Racial Disparities We were supposed to be talking about these Black teenagers’ aspirations to become doctors, not their fears about becoming patients. I wanted to tellHIV INFECTION
Key Clinical Points HIV Infection — Screening, Diagnosis, and Treatment Despite extensive knowledge about human immunodeficiency virus (HIV), the number of cases of incident HIV infection AN ALLERGIC BASIS FOR ABDOMINAL PAIN Irritable Bowel Syndrome and Immunity Recent findings based on a mouse model suggest that a peripheral immune mechanism may underlie the symptoms associated with abdominal pain in patients with irr THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of NEJM WEEKLY CME PROGRAM NEJM automatically tracks your completion of Weekly CME activities through the My Account section of NEJM.org. Certificates for CME record-keeping are available for download, and, where applicable PERSONAL SUBSCRIPTIONS Personal Subscriptions. A subscription to the New England Journal of Medicine (NEJM) — the world’s most respected general medical journal — keeps you current in the rapidly changing field of EDITORS AND PUBLISHERS PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SUTIMLIMAB IN COLD AGGLUTININ DISEASE PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZED Abstract Background Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poorquality of life,
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NEJM KNOWLEDGE+
“NEJM Knowledge+ has been a positive step for our program and reflects our commitment to residents’ success. The powerful thing about NEJM Knowledge+ is the way it can track what residents are working on, how far they have gone, how much time they’re spendingand where they are.
ROTATION PREP
The Art of Leading with the Right Balance as a Senior Resident. Although every resident develops his or her own style for each of these roles, the following practical strategies were discussed in a NEJM Resident 360 discussion (How to Lead a Team on the Wards: The Artto
THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of NEJM WEEKLY CME PROGRAM NEJM automatically tracks your completion of Weekly CME activities through the My Account section of NEJM.org. Certificates for CME record-keeping are available for download, and, where applicable PERSONAL SUBSCRIPTIONS Personal Subscriptions. A subscription to the New England Journal of Medicine (NEJM) — the world’s most respected general medical journal — keeps you current in the rapidly changing field of EDITORS AND PUBLISHERS PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SUTIMLIMAB IN COLD AGGLUTININ DISEASE PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZED Abstract Background Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poorquality of life,
EDITORIAL POLICIES
NEJM KNOWLEDGE+
“NEJM Knowledge+ has been a positive step for our program and reflects our commitment to residents’ success. The powerful thing about NEJM Knowledge+ is the way it can track what residents are working on, how far they have gone, how much time they’re spendingand where they are.
ROTATION PREP
The Art of Leading with the Right Balance as a Senior Resident. Although every resident develops his or her own style for each of these roles, the following practical strategies were discussed in a NEJM Resident 360 discussion (How to Lead a Team on the Wards: The Artto
THE NEW ENGLAND JOURNAL OF MEDICINE: THIS WEEK'S TABLE OF In this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide NEPHROLOGY ARTICLES: THE NEW ENGLAND JOURNAL OF MEDICINE Nephrology. Monoclonal gammopathy of renal significance is a B-cell or plasma-cell clonal disorder that does not meet the criteria for cancer but produces a monoclonal immunoglobulin that leads to NEJM REVIEW CME PROGRAM American Academy of Family Physicians (AAFP) The AAFP has reviewed the NEJM Review CME Program, and deemed it acceptable for AAFP credit.Term
ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2 Recently Published Articles. Sotorasib for Lung Cancers with KRAS p.G12C Mutation F. Skoulidis et al. ; Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer A.N.J. Tutt et ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
LEFT ATRIAL APPENDAGE OCCLUSION DURING CARDIAC SURGERY TO The title of the Visual Abstract is Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke. In a multicenter, randomized, controlled trial involving 4811 adults with a history of ABROCITINIB VERSUS PLACEBO OR DUPILUMAB FOR ATOPIC In this trial, abrocitinib at a dose of either 200 mg or 100 mg once daily resulted in significantly greater reductions in signs and symptoms of moderate-to-severe atopic dermatitis than placebo THE PATHOPHYSIOLOGY OF RACIAL DISPARITIES The Pathophysiology of Racial Disparities We were supposed to be talking about these Black teenagers’ aspirations to become doctors, not their fears about becoming patients. I wanted to tellHIV INFECTION
Key Clinical Points HIV Infection — Screening, Diagnosis, and Treatment Despite extensive knowledge about human immunodeficiency virus (HIV), the number of cases of incident HIV infection AN ALLERGIC BASIS FOR ABDOMINAL PAIN Irritable Bowel Syndrome and Immunity Recent findings based on a mouse model suggest that a peripheral immune mechanism may underlie the symptoms associated with abdominal pain in patients with irr THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of NEJM WEEKLY CME PROGRAM NEJM automatically tracks your completion of Weekly CME activities through the My Account section of NEJM.org. Certificates for CME record-keeping are available for download, and, where applicable PERSONAL SUBSCRIPTIONS Personal Subscriptions. A subscription to the New England Journal of Medicine (NEJM) — the world’s most respected general medical journal — keeps you current in the rapidly changing field of EDITORS AND PUBLISHERS PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SUTIMLIMAB IN COLD AGGLUTININ DISEASE PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZED Abstract Background Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poorquality of life,
EDITORIAL POLICIES
NEJM KNOWLEDGE+
“NEJM Knowledge+ has been a positive step for our program and reflects our commitment to residents’ success. The powerful thing about NEJM Knowledge+ is the way it can track what residents are working on, how far they have gone, how much time they’re spendingand where they are.
ROTATION PREP
The Art of Leading with the Right Balance as a Senior Resident. Although every resident develops his or her own style for each of these roles, the following practical strategies were discussed in a NEJM Resident 360 discussion (How to Lead a Team on the Wards: The Artto
THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of NEJM WEEKLY CME PROGRAM NEJM automatically tracks your completion of Weekly CME activities through the My Account section of NEJM.org. Certificates for CME record-keeping are available for download, and, where applicable PERSONAL SUBSCRIPTIONS Personal Subscriptions. A subscription to the New England Journal of Medicine (NEJM) — the world’s most respected general medical journal — keeps you current in the rapidly changing field of EDITORS AND PUBLISHERS PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SUTIMLIMAB IN COLD AGGLUTININ DISEASE PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZED Abstract Background Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poorquality of life,
EDITORIAL POLICIES
NEJM KNOWLEDGE+
“NEJM Knowledge+ has been a positive step for our program and reflects our commitment to residents’ success. The powerful thing about NEJM Knowledge+ is the way it can track what residents are working on, how far they have gone, how much time they’re spendingand where they are.
ROTATION PREP
The Art of Leading with the Right Balance as a Senior Resident. Although every resident develops his or her own style for each of these roles, the following practical strategies were discussed in a NEJM Resident 360 discussion (How to Lead a Team on the Wards: The Artto
THE NEW ENGLAND JOURNAL OF MEDICINE: THIS WEEK'S TABLE OF In this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2 Recently Published Articles. Sotorasib for Lung Cancers with KRAS p.G12C Mutation F. Skoulidis et al. ; Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer A.N.J. Tutt et NEPHROLOGY ARTICLES: THE NEW ENGLAND JOURNAL OF MEDICINE Nephrology. Monoclonal gammopathy of renal significance is a B-cell or plasma-cell clonal disorder that does not meet the criteria for cancer but produces a monoclonal immunoglobulin that leads to NEJM REVIEW CME PROGRAM American Academy of Family Physicians (AAFP) The AAFP has reviewed the NEJM Review CME Program, and deemed it acceptable for AAFP credit.Term
ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
THROMBOEMBOLIC EVENTS IN THE SOUTH AFRICAN AD26.COV2.S Rare Thromboembolic Events among Vaccinated South Africans Among 288,368 South African health care workers who received the Ad26.COV2.S vaccine, no cases of vaccine-induced immune thrombotic thromb LEFT ATRIAL APPENDAGE OCCLUSION DURING CARDIAC SURGERY TO The title of the Visual Abstract is Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke. In a multicenter, randomized, controlled trial involving 4811 adults with a history of NEJM KNOWLEDGE+ QUESTION OF THE WEEK For June 8, 2021. A 63-year-old man with a history of hypertension, type 2 diabetes, chronic obstructive pulmonary disease, chronic low back pain, and chronic hepatitis C virus infection with decompensated cirrhosis presents to the emergency department with weakness, low-grade fevers, and fatigue for the past week. THE PATHOPHYSIOLOGY OF RACIAL DISPARITIES The Pathophysiology of Racial Disparities We were supposed to be talking about these Black teenagers’ aspirations to become doctors, not their fears about becoming patients. I wanted to tell MUTANT UBA1 AND SEVERE ADULT-ONSET AUTOINFLAMMATORY To the Editor: Beck and colleagues (Dec. 31 issue)1 describe a new autoinflammatory disorder named the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome exclusively in male THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of NEJM WEEKLY CME PROGRAM NEJM automatically tracks your completion of Weekly CME activities through the My Account section of NEJM.org. Certificates for CME record-keeping are available for download, and, where applicable PERSONAL SUBSCRIPTIONS Personal Subscriptions. A subscription to the New England Journal of Medicine (NEJM) — the world’s most respected general medical journal — keeps you current in the rapidly changing field of EDITORS AND PUBLISHERS PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SUTIMLIMAB IN COLD AGGLUTININ DISEASE PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZED Abstract Background Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poorquality of life,
EDITORIAL POLICIES
NEJM KNOWLEDGE+
“NEJM Knowledge+ has been a positive step for our program and reflects our commitment to residents’ success. The powerful thing about NEJM Knowledge+ is the way it can track what residents are working on, how far they have gone, how much time they’re spendingand where they are.
ROTATION PREP
The Art of Leading with the Right Balance as a Senior Resident. Although every resident develops his or her own style for each of these roles, the following practical strategies were discussed in a NEJM Resident 360 discussion (How to Lead a Team on the Wards: The Artto
THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of NEJM WEEKLY CME PROGRAM NEJM automatically tracks your completion of Weekly CME activities through the My Account section of NEJM.org. Certificates for CME record-keeping are available for download, and, where applicable PERSONAL SUBSCRIPTIONS Personal Subscriptions. A subscription to the New England Journal of Medicine (NEJM) — the world’s most respected general medical journal — keeps you current in the rapidly changing field of EDITORS AND PUBLISHERS PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SUTIMLIMAB IN COLD AGGLUTININ DISEASE PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZED Abstract Background Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poorquality of life,
EDITORIAL POLICIES
NEJM KNOWLEDGE+
“NEJM Knowledge+ has been a positive step for our program and reflects our commitment to residents’ success. The powerful thing about NEJM Knowledge+ is the way it can track what residents are working on, how far they have gone, how much time they’re spendingand where they are.
ROTATION PREP
The Art of Leading with the Right Balance as a Senior Resident. Although every resident develops his or her own style for each of these roles, the following practical strategies were discussed in a NEJM Resident 360 discussion (How to Lead a Team on the Wards: The Artto
THE NEW ENGLAND JOURNAL OF MEDICINE: THIS WEEK'S TABLE OF In this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2 Recently Published Articles. Sotorasib for Lung Cancers with KRAS p.G12C Mutation F. Skoulidis et al. ; Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer A.N.J. Tutt et NEPHROLOGY ARTICLES: THE NEW ENGLAND JOURNAL OF MEDICINE Nephrology. Monoclonal gammopathy of renal significance is a B-cell or plasma-cell clonal disorder that does not meet the criteria for cancer but produces a monoclonal immunoglobulin that leads to NEJM REVIEW CME PROGRAM American Academy of Family Physicians (AAFP) The AAFP has reviewed the NEJM Review CME Program, and deemed it acceptable for AAFP credit.Term
ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Conclusions. Among patients with resected esophageal or gastroesophageal junction cancer who had received neoadjuvant chemoradiotherapy, disease-free survival was significantly longeramong those
THROMBOEMBOLIC EVENTS IN THE SOUTH AFRICAN AD26.COV2.S Rare Thromboembolic Events among Vaccinated South Africans Among 288,368 South African health care workers who received the Ad26.COV2.S vaccine, no cases of vaccine-induced immune thrombotic thromb LEFT ATRIAL APPENDAGE OCCLUSION DURING CARDIAC SURGERY TO The title of the Visual Abstract is Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke. In a multicenter, randomized, controlled trial involving 4811 adults with a history of NEJM KNOWLEDGE+ QUESTION OF THE WEEK For June 8, 2021. A 63-year-old man with a history of hypertension, type 2 diabetes, chronic obstructive pulmonary disease, chronic low back pain, and chronic hepatitis C virus infection with decompensated cirrhosis presents to the emergency department with weakness, low-grade fevers, and fatigue for the past week. THE PATHOPHYSIOLOGY OF RACIAL DISPARITIES The Pathophysiology of Racial Disparities We were supposed to be talking about these Black teenagers’ aspirations to become doctors, not their fears about becoming patients. I wanted to tell MUTANT UBA1 AND SEVERE ADULT-ONSET AUTOINFLAMMATORY To the Editor: Beck and colleagues (Dec. 31 issue)1 describe a new autoinflammatory disorder named the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome exclusively in male THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of NEJM WEEKLY CME PROGRAM NEJM Catalyst NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. NEJM JournalWatch
PERSONAL SUBSCRIPTIONS A subscription to the New England Journal of Medicine (NEJM) — the world’s most respected general medical journal — keeps you current in the rapidly changing field of medicine by providing EDITORS AND PUBLISHERS PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SUTIMLIMAB IN COLD AGGLUTININ DISEASEEDITORIAL POLICIES
PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZED Abstract Background Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poorquality of life,
NEJM KNOWLEDGE+
“NEJM Knowledge+ has been a positive step for our program and reflects our commitment to residents’ success. The powerful thing about NEJM Knowledge+ is the way it can track what residents are working on, how far they have gone, how much time they’re spendingand where they are.
ROTATION PREP
For many medical trainees, transitioning from having a question for a research project to taking the next steps is difficult. Finding an appropriate mentor, getting ethics approval, collecting data, performing analyses, and writing up a project for publication are particularly hard when added to the pressures and stresses of medical school or residency. THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of NEJM WEEKLY CME PROGRAM NEJM Catalyst NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. NEJM JournalWatch
PERSONAL SUBSCRIPTIONS A subscription to the New England Journal of Medicine (NEJM) — the world’s most respected general medical journal — keeps you current in the rapidly changing field of medicine by providing EDITORS AND PUBLISHERS PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SUTIMLIMAB IN COLD AGGLUTININ DISEASEEDITORIAL POLICIES
PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZED Abstract Background Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poorquality of life,
NEJM KNOWLEDGE+
“NEJM Knowledge+ has been a positive step for our program and reflects our commitment to residents’ success. The powerful thing about NEJM Knowledge+ is the way it can track what residents are working on, how far they have gone, how much time they’re spendingand where they are.
ROTATION PREP
For many medical trainees, transitioning from having a question for a research project to taking the next steps is difficult. Finding an appropriate mentor, getting ethics approval, collecting data, performing analyses, and writing up a project for publication are particularly hard when added to the pressures and stresses of medical school or residency. THE NEW ENGLAND JOURNAL OF MEDICINE: THIS WEEK'S TABLE OF Explore the table of contents of the current issue of the New England Journal of Medicine. ADJUVANT OLAPARIB FOR PATIENTS WITH BRCA1- OR BRCA2 Recently Published Articles. Sotorasib for Lung Cancers with KRAS p.G12C Mutation F. Skoulidis et al. ; Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer A.N.J. Tutt et NEPHROLOGY ARTICLES: THE NEW ENGLAND JOURNAL OF MEDICINE Case Records of the Massachusetts General HospitalMay 20, 2021 Case 15-2021: A 76-Year-Old Woman with Nausea, Diarrhea, and Acute Kidney Failure Yeku O.O., Medford A.J., Fenves A.Z., and Uljon S.N NEJM REVIEW CME PROGRAM Comprehensive, Convenient, Cost Effective The NEJM Review CME Program supports your commitment to lifelong learning while helping you meet requirements for licensure, certification, and credentialing. HIPAA AND THE LEAK OF “DEIDENTIFIED” EHR DATA HIPAA and the Leak of “Deidentified” EHR Data Although patients (and their physicians) still have difficulty obtaining complete medical record information in a timely fashion, HIPAA policies ADJUVANT NIVOLUMAB IN RESECTED ESOPHAGEAL OR Abstract Background No adjuvant treatment has been established for patients who remain at high risk for recurrence after neoadjuvant chemoradiotherapy and surgery for esophageal or gastroesophageal THE PATHOPHYSIOLOGY OF RACIAL DISPARITIES The Pathophysiology of Racial Disparities We were supposed to be talking about these Black teenagers’ aspirations to become doctors, not their fears about becoming patients. I wanted to tell LEFT ATRIAL APPENDAGE OCCLUSION DURING CARDIAC SURGERY TO The title of the Visual Abstract is Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke. In a multicenter, randomized, controlled trial involving 4811 adults with a history of MUTANT UBA1 AND SEVERE ADULT-ONSET AUTOINFLAMMATORY To the Editor: Beck and colleagues (Dec. 31 issue)1 describe a new autoinflammatory disorder named the VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome exclusively in male AN ALLERGIC BASIS FOR ABDOMINAL PAIN Irritable Bowel Syndrome and Immunity Recent findings based on a mouse model suggest that a peripheral immune mechanism may underlie the symptoms associated with abdominal pain in patients with irr TRY THIS SPECIAL BONUS OFFER SUBSCRIBE NOW AND GET 8 FREE ISSUES * 52 60 print issues (optional) * 52 60 weeks of full NEJM.org content back to 1990 * 52 60 NEJM iPad Edition issues * 20 FREE online CME exams * 50 FREE online article views from the NEJM archive (1812-1989)Subscribe Now
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* October 17, 2019 Vol. 381 No. 16 * October 10, 2019 Vol. 381 No. 15 * October 3, 2019 Vol. 381 No. 14 * Browse full issue index * Browse recently published Browse full issue index Recently Published Articles * Discrimination, Abuse, Harassment, and Burnout in Surgical Residency Training Y.-Y. Hu et al. * Modernizing the FDA’s 510(k) Pathway V.K. Rathi et al. * Enabling Healthful Aging for All — The National Academy of Medicine Grand Challenge in Healthy Longevity V.J. Dzau et al. * Soccer and Mortality — Good News and Bad News R.A. Stern * Neurodegenerative Disease Mortality among Former Professional Soccer Players D.F. Mackay et al. * Beta-Blockers in COPD — A Controversy Resolved? W. MacNee Browse recently published* Learning/CME
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* Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction * Encorafenib, Binimetinib, and Cetuximab in _BRAF_ V600E–MutatedColorectal Cancer
* Hereditary Thrombotic Thrombocytopenic Purpura * Challenge Yourself * Interactive Medical Cases* Image Challenge
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* Special Article Meeting of the American College of Surgeons MISTREATMENT AND BURNOUT AMONG SURGICAL RESIDENTS _Y.-Y. Hu and Others_ In a national survey of 7409 surgical residents, 32% reported discrimination based on their self-identified gender, 32% verbal or physical abuse, 10% sexual harassment, and 38% burnout symptoms. Mistreatment was more frequently reported by female residents, and burnout symptoms were more common among residents who reportedmistreatment.
_Oct 28_
* Original Article MEDICAL VS. SURGICAL TREATMENT FOR REFRACTORY HEARTBURN _S.J. Spechler and Others_ Patients who were referred to Veterans Affairs gastroenterology clinics with heartburn unresponsive to a proton-pump inhibitor had comprehensive evaluation for eligibility for a trial comparing Nissen fundoplication surgery with medical therapy. In the minority of patients who were confirmed to have PPI-refractory and reflux-related heartburn, surgery was more effective than medical treatment in controlling reflux symptoms._Oct 17_
EDITORIAL Think First, Cut Last — Lessons from a Clinical Trial of Refractory Heartburn*
*
Original Article
SACUBITRIL–VALSARTAN IN HEART FAILURE WITH PRESERVED LVEF _S.D. Solomon and Others_ Patients with heart failure with preserved ejection fraction were assigned to receive sacubitril–valsartan or valsartan. At a median of 35 months, there was no significant between-group difference in the composite outcome of total hospitalizations for heart failure or death from cardiovascular causes._Oct 24_
EDITORIAL PARAGON-HF — Why We Do Randomized, Controlled ClinicalTrials
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* Perspective GOAL-CONCORDANT CARE_S.D. Halpern_
The importance of delivering goal-concordant care to seriously ill patients is widely recognized. Yet there are no methods that can reliably and accurately be used to measure whether care that was provided to patients was concordant with their goals._Oct 24_
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* Perspective MEDICAL DEFERRED ACTION — LIVING ON BORROWED TIME _L. Ganapathi and Others_ Eliminating medical deferred action for immigrant children with highly complex conditions or the immigrant parents of U.S.-citizen children with such conditions would be a death sentence. How can physicians stand up to an administration that threatens patients’ lives?_Oct 24_
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Recent Information on E-Cigarettes and Vaping-Related DiseaseImage of the Week
CALCINOSIS
— This
77-year-old right-handed woman presented with slowly progressive, painful swelling of her fingertips.ORIGINAL RESEARCH
*
*
Original Article
GENOTYPE-GUIDED USE OF P2Y12 INHIBITORS IN PRIMARY PCI _D.M.F. Claassens and Others_ Patients undergoing primary PCI were randomly assigned to either a genotype-guided strategy for selecting a P2Y12 inhibitor or to standard treatment with ticagrelor or prasugrel. At 12 months, genotype-guided therapy was noninferior to standard treatment with respect to thrombotic events and resulted in a lower incidence ofbleeding.
_Oct 24_
EDITORIAL Clopidogrel Pharmacogenetics — Why the Wait?*
* Original Article SIGNALING PATHWAY INHIBITION IN COLORECTAL CANCER _S. Kopetz and Others_ Colorectal cancers with _BRAF_ mutations have an aggressive natural history and are often resistant to therapy. A treatment regimen that combined BRAF inhibition, MET inhibition, and blocking of EGFR signaling resulted in a response rate of 26% and a median overall survival of 9 months._Oct 24_
* Original Article Brief Report TIMELY DEVELOPMENT OF A MUTATION-SPECIFIC DRUG _J. Kim and Others_ A child with a neuronal ceroid lipofuscinosis was found to carry loss-of-function mutations in the gene _MFSD8_ (_CLN7_). A year after genetic diagnosis, the child began treatment with an oligonucleotide drug that was designed to correct the aberrant pre–messenger RNA splicing caused by one of these mutations._Oct 24_
EDITORIAL Drug Regulation in the Era of Individualized Therapies*
* Original Article
VAPING-INDUCED LUNG INJURY _J.E. Layden and Others_ Vaping use has rapidly increased. In this report from the Wisconsin and Illinois departments of public health, a severe respiratory illness in otherwise healthy young people is described. Of the 53 case patients identified, 94% were hospitalized, 32% were intubated, and 1person has died.
_Sep 06_
EDITORIAL Vaping-Induced Lung Injury*
* Correspondence PATHOLOGY OF VAPING-ASSOCIATED LUNG INJURY _Y.M. Butt and Others_ This letter describes findings in 17 patients with a history of vaping who had lung biopsies after presenting with symptoms and bilateral pulmonary opacities that led to a clinical diagnosis of vaping-associated lung injury. The lung histopathology is described, along with some preliminary insights into the pathogenesis of acutelung injury.
_Oct 02_
CLINICAL PRACTICE AND REVIEW*
*
Clinical
Implications of Basic ResearchMODELING
THE PLACENTA _T. Ezashi, D.J. Schust, and L.C. Schulz_ Placental health is critical to fetal health, but modeling the placenta is difficult. A recent study shows that both human and porcine stem-cell cultures can, in fact, be efficiently differentiated into trophoblasts and also converted into trophoblast stem cells._Oct 24_
* Review Article LIPID MANAGEMENT TO PREVENT CVD _E.D. Michos, J.W. McEvoy, and R.S. Blumenthal_ Management of serum cholesterol level is a central objective in preventing cardiovascular events. Current guidelines recommend calculation of cardiovascular risk, with treatment decisions based on these data and clinician–patient discussion of risk. Statins remain the first line of pharmacotherapy._Oct 17_
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* Review Article ZIKA VIRUS AND ITS ASSOCIATED DISEASES _D. Musso, A.I. Ko, and D. Baud_ Zika is a mosquito-borne flavivirus that can cause congenital defects, including microcephaly. Although most Zika virus infections are asymptomatic, rash, fever, arthralgia, myalgia, and conjunctivitis can develop in some people. The Guillain–Barré syndrome occurs in 2 to 3 patients per 10,000 with Zika virus infection._Oct 10_
* Review Article HEREDITARY THROMBOTIC THROMBOCYTOPENIC PURPURA _J.A. Kremer Hovinga and J.N.George_
Hereditary thrombotic thrombocytopenic purpura is an autosomal recessive disorder caused by the absence of a functional protease (ADAMTS13) that processes von Willebrand factor multimers into smaller fragments. The multimers bind to platelets and initiate abnormal clotting, thrombosis, and hemolysis._Oct 24_
* Review Article NEUROSYPHILIS_A.H. Ropper_
Neurosyphilis, the result of invasion of the nervous system by _Treponema pallidum_, can occur at any time after primary infection and is altered by HIV coinfection. Serologic diagnosis with testing of blood and CSF is imperfect, but some general rules provide guidance._Oct 03_
*
* Perspective GETTING COMFORTABLE WITH RISK _R.A. Montgomery_ In 2018, knowing that he would become infected, a transplant surgeon received a heart transplant from a donor with hepatitis C who’d died from a heroin overdose. Accepting a high-risk organ was a deliberate decision made long before he was offered the heart._Oct 24_
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* Editorial DRUG REGULATION IN THE ERA OF INDIVIDUALIZED THERAPIES _J. Woodcock and P. Marks_ Janet Woodcock and Peter Marks discuss the challenges inherent in evaluating the safety and approving the use of drugs developed in “N-of-one” situations._Oct 24_
ORIGINAL ARTICLE Patient-Customized Oligonucleotide Therapy for a Rare Genetic DiseaseCOMMENTARY
* Perspective _Oct 24_ MEDICAL DEFERRED ACTION — LIVING ON BORROWED TIME _L. Ganapathi and Others_ * Perspective _Oct 23_ MODERNIZING THE FDA’S 510(K) PATHWAY _V.K. Rathi and J.S. Ross_ * Editorial _Oct 24_ PARAGON-HF — WHY WE DO RANDOMIZED, CONTROLLED CLINICAL TRIALS _C.M. O’Connor and C. deFilippi_ * Editorial _Oct 24_ CLOPIDOGREL PHARMACOGENETICS — WHY THE WAIT?_D.M. Roden_
* Editorial _Oct 24_ DRUG REGULATION IN THE ERA OF INDIVIDUALIZED THERAPIES _J. Woodcock and P. Marks_ * Perspective _Oct 24_ GOAL-CONCORDANT CARE_S.D. Halpern_
* Perspective _Oct 24_ GETTING COMFORTABLE WITH RISK_R.A. Montgomery_
CORRESPONDENCE
* Identification of Anonymous MRI Research Participants with Face-Recognition Software * Transfusion Timing and Volume in African Children with SevereAnemia
* Rituximab or Cyclosporine for Membranous Nephropathy * Systolic and Diastolic Blood Pressure and Cardiovascular Outcomes * Case 22-2019: A 65-Year-Old Woman with Myopathy. opens in new tab
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