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THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENT
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The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of THE NEW ENGLAND JOURNAL OF MEDICINE: THIS WEEK'S TABLE OF In this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SOTORASIB FOR LUNG CANCERS WITH KRAS P.G12C MUTATION PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZEDSEE MORE ONNEJM.ORG
FOUR-MONTH RIFAPENTINE REGIMENS WITH OR WITHOUT We conducted a phase 3 clinical trial to determine whether treatment regimens that included rifapentine, at a once-daily dose of 1200 mg, with or without moxifloxacin, at a once-daily dose of 400 THE NEW ENGLAND JOURNAL OF MEDICINE: RESEARCH & REVIEWCORONAVIRUSORIGINAL ARTICLESPECIALTIESMULTIMEDIACURRENTISSUELEARNING/CME
The New England Journal of Medicine (NEJM) is a weekly general medical journal that publishes new medical research and review articles, and editorial opinion on a wide variety of topics of THE NEW ENGLAND JOURNAL OF MEDICINE: THIS WEEK'S TABLE OF In this trial, adults with obesity without diabetes were randomly assigned, after an 8-week low-calorie diet, to 1 year of placebo, an exercise program, liraglutide, or exercise plus liraglutide PRELIMINARY FINDINGS OF MRNA COVID-19 VACCINE SAFETY IN n engl j med nejm.org 3 mRNA Covid-19 Vaccine Safety in Pregnant Persons Activities (MedDRA), version 23.1.13 We used a pregnancy-status question in the VAERS form and a SOTORASIB FOR LUNG CANCERS WITH KRAS P.G12C MUTATION PHYSICAL REHABILITATION FOR OLDER PATIENTS HOSPITALIZEDSEE MORE ONNEJM.ORG
FOUR-MONTH RIFAPENTINE REGIMENS WITH OR WITHOUT We conducted a phase 3 clinical trial to determine whether treatment regimens that included rifapentine, at a once-daily dose of 1200 mg, with or without moxifloxacin, at a once-daily dose of 400 THE NEW ENGLAND JOURNAL OF MEDICINE: TABLE OF CONTENTS 1659-1660. Audio Interview: Advice for Clinicians on Covid-19 Vaccines and Social Restrictions. E.J. Rubin, L.R. Baden, and S. Morrissey. In this audio interview conducted on April 27, 2021, the SAFETY AND EFFICACY OF THE BNT162B2 MRNA COVID-19 VACCINE A two-dose regimen of BNT162b2 (30 μg per dose, given 21 days apart) was found to be safe and 95% effective against Covid-19. The vaccinemet
MAINTAINING SAFETY WITH SARS-COV-2 VACCINES 644 n engl j med 384;7 nejm.org February 18, 2021 The new england journal of medicine issued a pause on vaccination with the Pfizer– BioNTech SARS-CoV-2 mRNA vaccine, to exclude any person with ONCE-WEEKLY SEMAGLUTIDE IN ADULTS WITH OVERWEIGHT OR Abstract Background Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an a RIVAROXABAN WITH OR WITHOUT ASPIRIN IN STABLE BackgroundWe evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention. MethodsIn this double-blind trial AVACOPAN FOR THE TREATMENT OF ANCA-ASSOCIATED VASCULITIS Methods. In this randomized, controlled trial, we assigned patients with ANCA-associated vasculitis in a 1:1 ratio to receive oral avacopan at a dose of 30 mg twice daily or oral prednisone on a SUTIMLIMAB IN COLD AGGLUTININ DISEASE Abstract Background Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized SOTATERCEPT FOR THE TREATMENT OF PULMONARY ARTERIAL In this 24-week multicenter trial, we randomly assigned 106 adults who were receiving background therapy for pulmonary arterial hypertension to receive subcutaneous sotatercept at a dose of 0.3 mg TYMPANOSTOMY TUBES OR MEDICAL MANAGEMENT FOR RECURRENT Results. In our main, intention-to-treat analysis, the rate (±SE) of episodes of acute otitis media per child-year during a 2-year period was 1.48±0.08 in the tympanostomy-tube group and 1.56±0WWW.NEJM.ORG
A 53-year-old man who worked as a gardener presented to the emergency department with sudden onset of paralysis in the lower legs. He had a2-month
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* ASTHMA CONTROL IN BLACK CHILDREN AND ADULTS * CONTINUED ATTACKS ON IMMIGRANT FAMILIES * THE ELEMENT OF SURPRISE * CLOSED REDUCTION OF A FRACTURED AND DISLOCATED ANKLE* Current Issue
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* September 26, 2019 Vol. 381 No. 13Recent Issues
* September 19, 2019 Vol. 381 No. 12 * September 12, 2019 Vol. 381 No. 11 * September 5, 2019 Vol. 381 No. 10 * Browse full issue index * Browse recently published Browse full issue index Recently Published Articles * Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease G.W. Stone et al. * Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer M.D. Hellmann et al. * Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer R.L. Coleman et al. * Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer A. González-Martín et al. * Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma J. Larkin et al. * Total Hip Arthroplasty or Hemiarthroplasty for Hip Fracture The HEALTH Investigators Browse recently published* Learning/CME
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* Case 30-2019: A 65-Year-Old Woman with Lung Cancer and Chest Pain * Vedolizumab versus Adalimumab for Moderate-to-Severe UlcerativeColitis
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Original Article
Meeting of the European Society for Medical Oncology CHECKPOINT BLOCKADE IN LUNG CANCER _M.D. Hellmann and Others_ Patients with advanced non–small-cell lung cancer with a PD-L1 expression level of 1% or more of tumor cells were randomly assigned to receive nivolumab plus ipilimumab, nivolumab alone, or chemotherapy. Overall survival was significantly longer among the patients who received nivolumab plus ipilimumab than among those who received chemotherapy._Sep 28_
*
* Original Article Meeting of the European Society for Medical Oncology NIRAPARIB MAINTENANCE THERAPY IN OVARIAN CANCER _A. González-Martínand Others_
Patients with newly diagnosed advanced ovarian cancer were randomly assigned to receive daily niraparib, a PARP inhibitor, or placebo as maintenance therapy after having had a response to platinum-based chemotherapy. Progression-free survival was significantly longer in the niraparib group than in the placebo group, with some increase in the frequency of myelosuppression and nausea._Sep 28_
* Original Article Meeting of the European Society for Medical Oncology VELIPARIB IN ADVANCED OVARIAN CANCER _R.L. Coleman and Others_ The addition of veliparib, a PARP inhibitor, to induction chemotherapy and maintenance therapy in women with advanced ovarian cancer significantly improved progression-free survival over induction chemotherapy alone without maintenance therapy. The improvement was especially notable in patients with mutated _BRCA_ or homologous-recombination defects._Sep 28_
*
* Perspective LOSING HAHNEMANN _L.Rosenbaum_
The announcement that Hahnemann Hospital would soon close came as a shock to many people. Is the hospital a casualty of the push to optimize the distribution of limited resources — or a cautionary tale about the greed and corruption underlying our health care ills?_Sep 26_
*
* Perspective SUSTAINED ANIMUS TOWARD LATINO IMMIGRANTS _B.P. Dreyer_ U.S. policies are inflicting ongoing harm on migrant children, enacting an animus against immigrants that is baked into our history. U.S. physicians can advocate for immigrants’ basic human rights and can support, counsel, and nurture resilience in our Latino patients._Sep 26_
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14-year-old girl in Nepal presented with neck swelling, fever, and difficulty swallowing.ORIGINAL RESEARCH
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Original Article
MANAGING ASTHMA IN BLACK CHILDREN _M.E. Wechsler and Others_ Whether an increase in the dose of inhaled glucocorticoids or the addition of long-acting beta-agonists will lead to better outcomes in black children with moderate asthma is not known. Surprisingly, the data showed that increased doses of an inhaled glucocorticoid were as effective as addition of a LABA._Sep 26_
*
* Original Article Meeting of the European Society for Medical Oncology LONG-TERM OUTCOMES OF IMMUNOTHERAPY IN MELANOMA _J. Larkin and Others_ With a 5-year minimum follow-up in patients with metastatic melanoma, overall survival at 5 years was 52% with a combination of nivolumab plus ipilimumab, as compared with 44% with nivolumab alone and 26% with ipilimumab alone. Programmed cell death ligand 1 expression did not influence the response rate or progression-free survival._Sep 28_
* Original Article
Transcatheter Cardiovascular Therapeutics Conference PCI OR CABG FOR LEFT MAIN CORONARY DISEASE _G.W. Stone and Others_ In a randomized trial, 1905 patients with left main coronary artery disease were assigned to either percutaneous coronary intervention (PCI) or coronary-artery bypass grafting (CABG). At 5 years, the rates of the composite of death, stroke, or myocardial infarction were not significantly different between the two groups._Sep 28_
*
* Correspondence REAL-TIME SURVEILLANCE OF VAPING-INDUCED PULMONARY DISEASE _Y. Hswen and J.S.Brownstein_
This report documents the ongoing surge in cases of severe pulmonary disease associated with e-cigarettes, collecting online information from news aggregators, eyewitness reports, and official alerts._Sep 20_
*
* Correspondence VAPING TRENDS AMONG ADOLESCENTS, 2017–2019 _R. Miech and Others_ Vaping by adolescents is a concern because of the risks of nicotine addiction and because of reports of an association between vaping and acute lung injury. This nationally representative survey finds sharp increases in the frequency of vaping among 8th-, 10th-, and 12th-gradestudents.
_Sep 18_
PHYSICIAN JOBS
September 28, 2019
Chiefs / Directors / Dept. Heads Hospital Medicine Leader - Northwell HealthNew York
Critical Care Medicine California Neph Critical Care JobCalifornia
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Nephrology Position - Murray, UT - Intermountain Medical CenterMurray, Utah
Primary Care
Primary Care Physician Mountain Top, Pennsylvania Maternal-Fetal Medicine Maternal Fetal Medicine Attending PhysicianValhalla, New York
Surgery, Orthopedic
Orthopaedic Opportunity in South Carolina West Columbia, South Carolina nejmcareercenter.org CLINICAL PRACTICE AND REVIEW*
* Review Article UPDATE ON CLINICAL ASPECTS OF COPD _B.R. Celli and J.A. Wedzicha_ A pair of review articles examines our current understanding of the biology, diagnosis, and treatment of chronic obstructive pulmonary disease. This article focuses on the clinical aspects of COPD._Sep 26_
* Clinical Implications of Basic ResearchLASKER
AWARD FOR HER2 DISCOVERIES _D.F. Hayes_ The 2019 Lasker–DeBakey Clinical Medical Research Award goes to scientists whose work on the human epidermal growth factor receptor 2 in breast cancer launched a new era in clinical research and the practice of oncology._Sep 26_
* Correspondence A STUDY OF TELECONTRACEPTION _T. Jain, E.B. Schwarz, and A. Mehrotra_ Telecontraception is the provision of contraception prescriptions online as an alternative to traditional clinic visits. In this study, standardized patients were asked to represent a range of relative and absolute contraindications to oral contraceptives; they completed 63 interactive “visits” to assess the responses of nine sites offering telecontraception._Sep 26_
*
*
Review Article
UPDATE ON THE PATHOGENESIS OF COPD _A. Agustí and J.C. Hogg_ A pair of review articles examines our current understanding of the biology, diagnosis, and treatment of chronic obstructive pulmonary disease. This article focuses on the pathogenesis of COPD._Sep 26_
* Perspective UNSTEADY THOUGHTS_C.A. Conn_
Psychosis is a primitive agony that arises from the deepest part of the brain, unregulated by considered thought — raw, visceral, and turbulent. But much of its territory remains uncharted. How is a physician-mother to help her suffering sons?_Sep 26_
*
Clinical Spotlight ». opens in new tab Exploring controversial topics in the recent literature. FEATURED ARTICLE: Estrogen-Progestin Therapy Elevates Risk for Breast Cancer — Should This Influence Clinical Practice?. opens in new tab. opens in new tab
Which one of the following initial treatments is most appropriate for menopause-related vasomotor symptoms and sleep disturbances in a 48-year-old woman who underwent hysterectomy one year ago for fibroids, who has a history of hormone-receptor–negative breast cancer and recurrent deep-vein thrombosis, and whose only medicationis apixaban?
* Paroxetine 7.5 mg daily by mouth * Conjugated equine estrogens 0.625 mg daily by mouth * Gabapentin 300 mg three times daily by mouth * Clonidine 0.1 mg transdermal patch * Black cohosh by mouthVIDEOS
* Quick Take
STEP-UP THERAPY IN BLACKS WITH POORLY CONTROLLED ASTHMA01:53
* Quick Take
USING THE POLYPILL FOR CARDIOVASCULAR PREVENTION02:02
* Videos in Clinical Medicine CLOSED REDUCTION OF A FRACTURED AND DISLOCATED ANKLE11:15
* Quick Take
ROXADUSTAT FOR ANEMIA IN CHRONIC KIDNEY DISEASE01:53
* Quick Take
SAGE-217 FOR THE TREATMENT OF DEPRESSION02:04
* Quick Take
DOLUTEGRAVIR PLUS TENOFOVIR TO TREAT HIV01:51
* Quick Take
PARTICULATE AIR POLLUTION AND DAILY MORTALITY IN 652 CITIES02:28
* Quick Take
TEPLIZUMAB FOR PREVENTION OR DELAY OF TYPE 1 DIABETES01:51
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COMMENTARY
* Perspective _Sep 26_ SUSTAINED ANIMUS TOWARD LATINO IMMIGRANTS_B.P. Dreyer_
* Perspective _Sep 26_ LOSINGHAHNEMANN
_L. Rosenbaum_
* Editorial _Sep 26_ BIOLOGICS BEYOND ANTI-TNF AGENTS FOR ULCERATIVE COLITIS — EFFICACY, SAFETY, AND COST?_R.J. Farrell_
* Editorial _Sep 26_ EMERGING USE OF CRISPR TECHNOLOGY — CHASING THE ELUSIVE HIV CURE_C.H. June_
CORRESPONDENCE
* A Study of Telecontraception * Clinical and Genomic Risk in Adjuvant Therapy for Breast Cancer * C-Type Natriuretic Peptide Analogue Therapy in Children withAchondroplasia
* Intensive Glucose Control and Type 2 Diabetes — 15 Years On * Contrast-Associated Acute Kidney Injury. opens in new tab
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What are the top two challenges facing chronic disease management care at your organization today? * No formal organizational strategy for chronic disease management * Lack of team-based supports and approaches * Not enough leadership commitment * Insufficient care coordination to ensure the best outcomes * Patients lack the resources they need for self-management * Clinicians lack necessary time for patients with chronicconditions
* Clinicians don’t follow standardized clinical pathways * Costs too much for providers * Costs too much for patientsSee how your
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