GENOMIC SEQUENCING: TAPESTRY STUDY You can also contact the Center for Individualized Medicine for information on clinical studies and trials.. Support individualized medicine research. Generous donors and benefactors make studies like Tapestry possible. Your gift to the Center for Individualized Medicine supports translational research in areas such as genomic sequencing to enhance the electronic health record.

MICROBIOME PROGRAM

Microbiome Program. The invention of the microscope long ago allowed scientists to understand how bacteria can cause and transmit infections in humans. Now, using genomic sequencing, researchers are discovering that communities of bacteria inside and on every person's body, known collectively as the human microbiome, do much more for

people

POSTDOC CAREERS

Postdoc Careers. Our lab offers positions for postdoctoral research fellows to work on research projects alongside Dr. Lu and the lab team. Candidates interested in a postdoc position should hold a doctorate degree in biomedical engineering, polymer chemistry, or materials science and engineering, and have a demonstrated record of relevant research accomplishments as evidenced by their ADPKD CLASSIFICATION classification of typical adpkd calculator end user license agreement. important legal notice to all users: carefully read the following legal agreement before you start using the classification of typical adpkd calculator web-based application (the "web-based application"). SPINAL STENOSIS CLINICAL TRIALS A Study Comparing Either Cervical Spine, Head, Temporal Bone or Vasculature Treated with Metallic Implants Imaged with CT or MRI or Cerebral Angiogram to a MRI Zero Echo Time (ZTE) MRI Sequence Rochester, MN . The purpose of this study is to demonstrate the use of 3D ZTE imaging of the cervical spine to assess osseous neural foraminal stenosis and directly compare it to CT. KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

DAVID F. KALLMES, M.D. The research interests of David F. Kallmes, M.D., center on advancing the minimally invasive treatment options for patients with intracranial saccular aneurysms. Dr. Kallmes' preclinical laboratory is developing and testing multiple improvements to the microcoil technology used to treat this WILSON I. GONSALVES, M.D. Wilson I. Gonsalves, M.D., focuses his research on understanding the cellular metabolism of malignant plasma cells in diseases such as multiple myeloma by employing a variety of systems biology techniques in an integrated fashion. Dr. Gonsalves is also interested in enhancing the supportive care of patients with plasma cell disorders

by

VERONIQUE BELZIL, PH.D., M.S. Veronique Belzil, Ph.D., M.S., works on developing individualized approaches to treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and other related neurodegenerative diseases. Her laboratory aims to discover and characterize genetic, epigenetic and transcriptional changes SEAN J. PITTOCK, M.D. Sean J. Pittock, M.D., is the director of Mayo Clinic's Center for Multiple Sclerosis and Autoimmune Neurology and of Mayo's Neuroimmunology Research Laboratory. Dr. Pittock's clinical and laboratory expertise lies in modifying, for clinical application, the antibody assays developed by the Neuroimmunology Research Laboratory. GENOMIC SEQUENCING: TAPESTRY STUDY You can also contact the Center for Individualized Medicine for information on clinical studies and trials.. Support individualized medicine research. Generous donors and benefactors make studies like Tapestry possible. Your gift to the Center for Individualized Medicine supports translational research in areas such as genomic sequencing to enhance the electronic health record.

MICROBIOME PROGRAM

Microbiome Program. The invention of the microscope long ago allowed scientists to understand how bacteria can cause and transmit infections in humans. Now, using genomic sequencing, researchers are discovering that communities of bacteria inside and on every person's body, known collectively as the human microbiome, do much more for

people

POSTDOC CAREERS

Postdoc Careers. Our lab offers positions for postdoctoral research fellows to work on research projects alongside Dr. Lu and the lab team. Candidates interested in a postdoc position should hold a doctorate degree in biomedical engineering, polymer chemistry, or materials science and engineering, and have a demonstrated record of relevant research accomplishments as evidenced by their ADPKD CLASSIFICATION classification of typical adpkd calculator end user license agreement. important legal notice to all users: carefully read the following legal agreement before you start using the classification of typical adpkd calculator web-based application (the "web-based application"). SPINAL STENOSIS CLINICAL TRIALS A Study Comparing Either Cervical Spine, Head, Temporal Bone or Vasculature Treated with Metallic Implants Imaged with CT or MRI or Cerebral Angiogram to a MRI Zero Echo Time (ZTE) MRI Sequence Rochester, MN . The purpose of this study is to demonstrate the use of 3D ZTE imaging of the cervical spine to assess osseous neural foraminal stenosis and directly compare it to CT. KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

DAVID F. KALLMES, M.D. The research interests of David F. Kallmes, M.D., center on advancing the minimally invasive treatment options for patients with intracranial saccular aneurysms. Dr. Kallmes' preclinical laboratory is developing and testing multiple improvements to the microcoil technology used to treat this WILSON I. GONSALVES, M.D. Wilson I. Gonsalves, M.D., focuses his research on understanding the cellular metabolism of malignant plasma cells in diseases such as multiple myeloma by employing a variety of systems biology techniques in an integrated fashion. Dr. Gonsalves is also interested in enhancing the supportive care of patients with plasma cell disorders

by

VERONIQUE BELZIL, PH.D., M.S. Veronique Belzil, Ph.D., M.S., works on developing individualized approaches to treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and other related neurodegenerative diseases. Her laboratory aims to discover and characterize genetic, epigenetic and transcriptional changes SEAN J. PITTOCK, M.D. Sean J. Pittock, M.D., is the director of Mayo Clinic's Center for Multiple Sclerosis and Autoimmune Neurology and of Mayo's Neuroimmunology Research Laboratory. Dr. Pittock's clinical and laboratory expertise lies in modifying, for clinical application, the antibody assays developed by the Neuroimmunology Research Laboratory. ANTIVIRAL DRUGS AND COVID-19 The lab has developed a cooperative platform for cellular, molecular and computational techniques to provide groundbreaking new insights into COVID-19 druggability and improve our drug discovery efforts against SARS-CoV-2. Using a polypharmaceutical approach for COVID-19 has been used previously ANIMATIONS - DRUG DISCOVERY, DESIGN AND OPTIMIZATION FOR Animations. In animations developed by Mayo Clinic's Drug Discovery, Design and Optimization for Novel Therapeutics Laboratory, Dr. Caulfield's lab demonstrates algorithms used for structural biology, drug design and large conformational changes needed to understand biological processes that are important for probing behavior. OVERVIEW - DRUG DISCOVERY, DESIGN AND OPTIMIZATION FOR Overview. Mayo Clinic's Drug Discovery, Design and Optimization for Novel Therapeutics Laboratory is led by Thomas Caulfield, Ph.D., and focuses on the molecular interactions and driving forces that enable biomolecular activities to be studied at the atomic level. CONTACT - DRUG DISCOVERY, DESIGN AND OPTIMIZATION FOR Contact. Research in Mayo Clinic's Drug Discovery, Design and Optimization for Novel Therapeutics Lab is aimed at engineering and designing novel therapeutics that will ultimately lead to A STUDY TO EVALUATE NEWLY-DIAGNOSED IDIOPATHIC GENERALIZED Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices. Medical records

research — uses

COLLABORATORS

Collaborators. Dr. Caulfield's Drug Discovery, Design and Optimization for Novel Therapeutics Laboratory collaborates with other research experts and labs at Mayo Clinic focused on cellular mechanisms, genetics and biochemistry in multiple disease disorders. SPINAL STENOSIS CLINICAL TRIALS A Study Comparing Either Cervical Spine, Head, Temporal Bone or Vasculature Treated with Metallic Implants Imaged with CT or MRI or Cerebral Angiogram to a MRI Zero Echo Time (ZTE) MRI Sequence Rochester, MN . The purpose of this study is to demonstrate the use of 3D ZTE imaging of the cervical spine to assess osseous neural foraminal stenosis and directly compare it to CT. C DIFFICILE INFECTION CLINICAL TRIALS Kinetics of Clostridium Difficile Toxin PCR Positivity and Prediction of Recurrent Infection following Metronidazole or Vancomycin Therapy Rochester, MN . This study is to see if PCR test developed at Mayo Clinic to diagnosis C. Difficile infections is able to predict the risk of recurrent infection.

PATHOGENIC GENES

Pathogenic Genes. Variants of unknown significance are becoming a growing area of research within personal genomics, which generally falls within individualized medicine, a growing field that offers to pinpoint difficult-to-diagnosis patients with rare or untreatable

diseases.

RIBOSOME QUALITY CONTROL Ribosomal quality control during proofreading and frameshifting. The lab completed large scale simulations for a fully solvated ribosome containing over 3 million atoms and long time scales to achieve useful interrogation of rate-limiting steps and phenomena that underlie events crucial and related to ribosomopathies. ABOUT - CENTER FOR REGENERATIVE MEDICINE - MAYO CLINIC A unique aspect of the Center for Regenerative Medicine is that its activities are not just laboratory based or clinic based. They're both — and everything in between. Efforts in each of the center's programs, which build on Mayo's extensive research resources and clinical practice, span the full spectrum of discovery science,

translational

MUSCULOSKELETAL REGENERATION The musculoskeletal regeneration research team in the Center for Regenerative Medicine serves as a therapeutic pipeline from biomedical discovery to clinical implementation, improving treatments for patients with conditions of the muscles, tendons, cartilage, meniscus

and bone.

LUNG REGENERATION

ADPKD CLASSIFICATION classification of typical adpkd calculator end user license agreement. important legal notice to all users: carefully read the following legal agreement before you start using the classification of typical adpkd calculator web-based application (the "web-based application"). KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

FIBROMYALGIA CLINICAL TRIALS Fibromyalgia. The overall goal of this research is to identify patients in clinical practice that have unrecognized hypophosphatasia (HPP) and select appropriate candidates for therapy. The purpose of this proposal is to identify the prevalence of adults with hypophosphatasia within a previously identified fibromyalgia cohort at

our institution.

GEOFFREY (GEOFFREY B.) B. THOMPSON, M.D. Resident - General Surgery Mayo Graduate School of Medicine, Mayo Clinic College of Medicine. Fellow - Visiting Clinical Fellow in Pathology Brigham and Women's Hospital, Harvard Medical School. Resident - Anatomic Pathlolgy University of Massachusetts Medical

Center. Resident -

PAUL E. CROARKIN, D.O., M.S. Paul E. Croarkin, D.O., is focused on understanding the neurobiology, optimal treatment and classification of mood disorders in children and adolescents. This includes studies of repetitive transcranial magnetic stimulation (rTMS) for adolescent major depressive disorder; collaborative clinical PARAMETRIC AND NONPARAMETRIC: DEMYSTIFYING THE TERMS Parametric and Nonparametric: Demystifying the Terms . By Tanya Hoskin, a statistician in the Mayo Clinic Department of Health Sciences Research who provides consultations through the Mayo Clinic

CTSA BERD Resource.

SEAN J. PITTOCK, M.D. Sean J. Pittock, M.D., is the director of Mayo Clinic's Center for Multiple Sclerosis and Autoimmune Neurology and of Mayo's Neuroimmunology Research Laboratory. Dr. Pittock's clinical and laboratory expertise lies in modifying, for clinical application, the antibody assays developed by the Neuroimmunology Research Laboratory. ABOUT - CENTER FOR REGENERATIVE MEDICINE - MAYO CLINIC A unique aspect of the Center for Regenerative Medicine is that its activities are not just laboratory based or clinic based. They're both — and everything in between. Efforts in each of the center's programs, which build on Mayo's extensive research resources and clinical practice, span the full spectrum of discovery science,

translational

MUSCULOSKELETAL REGENERATION The musculoskeletal regeneration research team in the Center for Regenerative Medicine serves as a therapeutic pipeline from biomedical discovery to clinical implementation, improving treatments for patients with conditions of the muscles, tendons, cartilage, meniscus

and bone.

LUNG REGENERATION

ADPKD CLASSIFICATION classification of typical adpkd calculator end user license agreement. important legal notice to all users: carefully read the following legal agreement before you start using the classification of typical adpkd calculator web-based application (the "web-based application"). KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

FIBROMYALGIA CLINICAL TRIALS Fibromyalgia. The overall goal of this research is to identify patients in clinical practice that have unrecognized hypophosphatasia (HPP) and select appropriate candidates for therapy. The purpose of this proposal is to identify the prevalence of adults with hypophosphatasia within a previously identified fibromyalgia cohort at

our institution.

GEOFFREY (GEOFFREY B.) B. THOMPSON, M.D. Resident - General Surgery Mayo Graduate School of Medicine, Mayo Clinic College of Medicine. Fellow - Visiting Clinical Fellow in Pathology Brigham and Women's Hospital, Harvard Medical School. Resident - Anatomic Pathlolgy University of Massachusetts Medical

Center. Resident -

PAUL E. CROARKIN, D.O., M.S. Paul E. Croarkin, D.O., is focused on understanding the neurobiology, optimal treatment and classification of mood disorders in children and adolescents. This includes studies of repetitive transcranial magnetic stimulation (rTMS) for adolescent major depressive disorder; collaborative clinical PARAMETRIC AND NONPARAMETRIC: DEMYSTIFYING THE TERMS Parametric and Nonparametric: Demystifying the Terms . By Tanya Hoskin, a statistician in the Mayo Clinic Department of Health Sciences Research who provides consultations through the Mayo Clinic

CTSA BERD Resource.

SEAN J. PITTOCK, M.D. Sean J. Pittock, M.D., is the director of Mayo Clinic's Center for Multiple Sclerosis and Autoimmune Neurology and of Mayo's Neuroimmunology Research Laboratory. Dr. Pittock's clinical and laboratory expertise lies in modifying, for clinical application, the antibody assays developed by the Neuroimmunology Research Laboratory. ANTIVIRAL DRUGS AND COVID-19 The lab has developed a cooperative platform for cellular, molecular and computational techniques to provide groundbreaking new insights into COVID-19 druggability and improve our drug discovery efforts against SARS-CoV-2. Using a polypharmaceutical approach for COVID-19 has been used previously EDUCATION AND TRAINING Education and Training. The Drug Discovery, Design and Optimization for Novel Therapeutics Lab works on several hot areas of research for talented postdoctoral researchers and graduate students to OVERVIEW - DRUG DISCOVERY, DESIGN AND OPTIMIZATION FOR Overview. Mayo Clinic's Drug Discovery, Design and Optimization for Novel Therapeutics Laboratory is led by Thomas Caulfield, Ph.D., and focuses on the molecular interactions and driving forces that enable biomolecular activities to be studied at the atomic level. ANIMATIONS - DRUG DISCOVERY, DESIGN AND OPTIMIZATION FOR Animations. In animations developed by Mayo Clinic's Drug Discovery, Design and Optimization for Novel Therapeutics Laboratory, Dr. Caulfield's lab demonstrates algorithms used for structural biology, drug design and large conformational changes needed to understand biological processes that are important for probing behavior. CONTACT - DRUG DISCOVERY, DESIGN AND OPTIMIZATION FOR Contact. Research in Mayo Clinic's Drug Discovery, Design and Optimization for Novel Therapeutics Lab is aimed at engineering and designing novel therapeutics that will ultimately lead to

METHODS DEVELOPMENT

Methods Development Accelerated virtual wet lab. Drug development is expensive and laborious, largely due to the costs of synthesis and physical testing of compounds, the vast majority of which are not viable as pharmaceuticals for the purpose under investigation.

COLLABORATORS

Collaborators. Dr. Caulfield's Drug Discovery, Design and Optimization for Novel Therapeutics Laboratory collaborates with other research experts and labs at Mayo Clinic focused on cellular mechanisms, genetics and biochemistry in multiple disease disorders. DRUG DISCOVERY, DESIGN AND OPTIMIZATION FOR NOVEL Variants of unknown significance are becoming a growing area of research within personal genomics, which generally falls within individualized medicine, a growing field that offers to pinpoint difficult-to-diagnosis patients with rare or untreatable diseases. Additionally, understanding the proteins KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

RIBOSOME QUALITY CONTROL Ribosomal quality control during proofreading and frameshifting. The lab completed large scale simulations for a fully solvated ribosome containing over 3 million atoms and long time scales to achieve useful interrogation of rate-limiting steps and phenomena that underlie events crucial and related to ribosomopathies. PHARMACOGENOMICS FOR PATIENTS Pharmacogenomics Program Animation. The Pharmacogenomics Program investigates how variations in genes affect response to medications, thereby using a patient's genetic profile to predict a drug's efficacy, guide dosage and improve patient safety. KNEE CARTILAGE RESTORATION Mayo Clinic Sports Medicine Research led by Michael J. Stuart, M.D., has published research and current clinical trials on knee cartilage

regeneration.

ADPKD CLASSIFICATION classification of typical adpkd calculator end user license agreement. important legal notice to all users: carefully read the following legal agreement before you start using the classification of typical adpkd calculator web-based application (the "web-based application"). SPINAL STENOSIS CLINICAL TRIALS A Study to Assess Wound Closure Techniques in Primary Spine Surgery Using SPY Intra-operative Angiography Rochester, MN . The purpose of this study is to assess wound perfusion at the site of closure in primary spine surgery between running subcuticular suture, interrupted vertical mattress suture, and staple closure techniques.

LUNG REGENERATION

FIBROMYALGIA CLINICAL TRIALS Prevalence of Hypophosphatasia in Patients with Fibromyalgia at the Mayo Clinic Rochester, MN . The overall goal of this research is to identify patients in clinical practice that have unrecognized hypophosphatasia (HPP) and select appropriate candidates for therapy. PROSTATE BIOPSIES DOWN, COMPLICATIONS UP While absolute rates of biopsy and post-biopsy complications have decreased after several benchmark prostate-specific antigen (PSA) screening publications, the relative risk for each patient continues to increase, according to a new study by Mayo Clinic researchers.. The study is the largest to examine the impact of PSA screening trials and revised PSA screening guidelines on rates of prostate PAUL E. CROARKIN, D.O., M.S. Paul E. Croarkin, D.O., is focused on understanding the neurobiology, optimal treatment and classification of mood disorders in children and adolescents. This includes studies of repetitive transcranial magnetic stimulation (rTMS) for adolescent major depressive disorder; collaborative clinical GEOFFREY (GEOFFREY B.) B. THOMPSON, M.D. Advertising. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised. PARAMETRIC AND NONPARAMETRIC: DEMYSTIFYING THE TERMS Parametric and Nonparametric: Demystifying the Terms . By Tanya Hoskin, a statistician in the Mayo Clinic Department of Health Sciences Research who provides consultations through the Mayo Clinic

CTSA BERD Resource.

PHARMACOGENOMICS FOR PATIENTS Pharmacogenomics Program Animation. The Pharmacogenomics Program investigates how variations in genes affect response to medications, thereby using a patient's genetic profile to predict a drug's efficacy, guide dosage and improve patient safety. KNEE CARTILAGE RESTORATION Mayo Clinic Sports Medicine Research led by Michael J. Stuart, M.D., has published research and current clinical trials on knee cartilage

regeneration.

ADPKD CLASSIFICATION classification of typical adpkd calculator end user license agreement. important legal notice to all users: carefully read the following legal agreement before you start using the classification of typical adpkd calculator web-based application (the "web-based application"). SPINAL STENOSIS CLINICAL TRIALS A Study to Assess Wound Closure Techniques in Primary Spine Surgery Using SPY Intra-operative Angiography Rochester, MN . The purpose of this study is to assess wound perfusion at the site of closure in primary spine surgery between running subcuticular suture, interrupted vertical mattress suture, and staple closure techniques.

LUNG REGENERATION

FIBROMYALGIA CLINICAL TRIALS Prevalence of Hypophosphatasia in Patients with Fibromyalgia at the Mayo Clinic Rochester, MN . The overall goal of this research is to identify patients in clinical practice that have unrecognized hypophosphatasia (HPP) and select appropriate candidates for therapy. PROSTATE BIOPSIES DOWN, COMPLICATIONS UP While absolute rates of biopsy and post-biopsy complications have decreased after several benchmark prostate-specific antigen (PSA) screening publications, the relative risk for each patient continues to increase, according to a new study by Mayo Clinic researchers.. The study is the largest to examine the impact of PSA screening trials and revised PSA screening guidelines on rates of prostate PAUL E. CROARKIN, D.O., M.S. Paul E. Croarkin, D.O., is focused on understanding the neurobiology, optimal treatment and classification of mood disorders in children and adolescents. This includes studies of repetitive transcranial magnetic stimulation (rTMS) for adolescent major depressive disorder; collaborative clinical GEOFFREY (GEOFFREY B.) B. THOMPSON, M.D. Advertising. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised. PARAMETRIC AND NONPARAMETRIC: DEMYSTIFYING THE TERMS Parametric and Nonparametric: Demystifying the Terms . By Tanya Hoskin, a statistician in the Mayo Clinic Department of Health Sciences Research who provides consultations through the Mayo Clinic

CTSA BERD Resource.

SPINAL STENOSIS CLINICAL TRIALS A Study to Assess Wound Closure Techniques in Primary Spine Surgery Using SPY Intra-operative Angiography Rochester, MN . The purpose of this study is to assess wound perfusion at the site of closure in primary spine surgery between running subcuticular suture, interrupted vertical mattress suture, and staple closure techniques. PAUL E. CROARKIN, D.O., M.S. Paul E. Croarkin, D.O., is focused on understanding the neurobiology, optimal treatment and classification of mood disorders in children and adolescents. This includes studies of repetitive transcranial magnetic stimulation (rTMS) for adolescent major depressive disorder; collaborative clinical MUSCULOSKELETAL REGENERATION The musculoskeletal regeneration research team in the Center for Regenerative Medicine serves as a therapeutic pipeline from biomedical discovery to clinical implementation, improving treatments for patients with conditions of the muscles, tendons, cartilage, meniscus

and bone.

ROBERT B. JENKINS, M.D., PH.D. The research of Robert B. Jenkins, M.D., Ph.D., is focused on cancer genetics, particularly elucidation of the genetic events important for cancer initiation and progression. His primary interest is in the genetics of gliomas, where both his basic genetic studies and clinical translation activities PRIYA SAMPATHKUMAR, M.D. SUMMARY. My research interests include the epidemiology and control of antibiotic resistant organisms in the health care setting, healthcare associated infections, new modalities of treatment of staphylococcus

aureus infections.

PARAMETRIC AND NONPARAMETRIC: DEMYSTIFYING THE TERMS Parametric and Nonparametric: Demystifying the Terms . By Tanya Hoskin, a statistician in the Mayo Clinic Department of Health Sciences Research who provides consultations through the Mayo Clinic

CTSA BERD Resource.

WILLIAM G. MORICE, II, M.D., PH.D. The research of William G. Morice II, M.D., Ph.D., is focused on the diagnosis of blood and bone marrow cancers. In particular, his interests are in lymphoproliferative disorders of T cells and natural killer (NK) cells, plasma cells, and B cells. Dr. Morice studies these disorders using a variety DAVID F. KALLMES, M.D. The research interests of David F. Kallmes, M.D., center on advancing the minimally invasive treatment options for patients with intracranial saccular aneurysms. Dr. Kallmes' preclinical laboratory is developing and testing multiple improvements to the microcoil technology used to treat this JOY EMELIE (JOY) V. WOLFRAM, PH.D. SUMMARY. Do you want to revolutionize health care? Do you want to conduct groundbreaking research in nanomedicine? If you answered yes to these questions, Dr. Wolfram's Nanomedicine and Extracellular Vesicles Laboratory is for you! Join a group of researchers who are passionate about thinking differently to solve major health care

challenges.

ALEX A. ADJEI, M.D., PH.D. Advertising. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Mayo Clinic does not endorse any of the third party products and services advertised. (VOYAGER) STUDY OF AVAPRITINIB VS REGORAFENIB IN PATIENTS About this study. This is an open-label, randomized, Phase 3 study in patients with locally advanced unresectable or metastatic GIST (advanced GIST) of avapritinib (also known as BLU-285) versus regorafenib in patients previously treated with imatinib and 1 or 2

other TKIs.

MICROBIOME PROGRAM

Microbiome Program. The invention of the microscope long ago allowed scientists to understand how bacteria can cause and transmit infections in humans. Now, using genomic sequencing, researchers are discovering that communities of bacteria inside and on every person's body, known collectively as the human microbiome, do much more for

people

POSTDOC CAREERS

Postdoc Careers. Our lab offers positions for postdoctoral research fellows to work on research projects alongside Dr. Lu and the lab team. Candidates interested in a postdoc position should hold a doctorate degree in biomedical engineering, polymer chemistry, or materials science and engineering, and have a demonstrated record of relevant research accomplishments as evidenced by their ADPKD CLASSIFICATION classification of typical adpkd calculator end user license agreement. important legal notice to all users: carefully read the following legal agreement before you start using the classification of typical adpkd calculator web-based application (the "web-based application"). POLYARTERITIS NODOSA CLINICAL TRIALS The purpose of this clinical trial is to determine if low dose naltrexone is effective in improving health-related quality of life (HRQoL) among patients with vasculitis. Although it is a pilot study, a placebo-controlled component is used because of the prominent placebo group effect seen in studies with self-reported subjective

outcomes.

KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

DAVID F. KALLMES, M.D. The research interests of David F. Kallmes, M.D., center on advancing the minimally invasive treatment options for patients with intracranial saccular aneurysms. Dr. Kallmes' preclinical laboratory is developing and testing multiple improvements to the microcoil technology used to treat this WILSON I. GONSALVES, M.D. Wilson I. Gonsalves, M.D., focuses his research on understanding the cellular metabolism of malignant plasma cells in diseases such as multiple myeloma by employing a variety of systems biology techniques in an integrated fashion. Dr. Gonsalves is also interested in enhancing the supportive care of patients with plasma cell disorders

by

VERONIQUE BELZIL, PH.D., M.S. Veronique Belzil, Ph.D., M.S., works on developing individualized approaches to treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and other related neurodegenerative diseases. Her laboratory aims to discover and characterize genetic, epigenetic and transcriptional changes GANG ZHENG, M.D., PH.D. Gang Zheng, M.D., Ph.D., is board certified in both molecular pathology and hematopathology. His clinical and research interests include implementing cutting-edge molecular technologies in clinical diagnostics of cancer and applying data mining to integrate genomic, morphologic and clinical data for (VOYAGER) STUDY OF AVAPRITINIB VS REGORAFENIB IN PATIENTS About this study. This is an open-label, randomized, Phase 3 study in patients with locally advanced unresectable or metastatic GIST (advanced GIST) of avapritinib (also known as BLU-285) versus regorafenib in patients previously treated with imatinib and 1 or 2

other TKIs.

MICROBIOME PROGRAM

Microbiome Program. The invention of the microscope long ago allowed scientists to understand how bacteria can cause and transmit infections in humans. Now, using genomic sequencing, researchers are discovering that communities of bacteria inside and on every person's body, known collectively as the human microbiome, do much more for

people

POSTDOC CAREERS

Postdoc Careers. Our lab offers positions for postdoctoral research fellows to work on research projects alongside Dr. Lu and the lab team. Candidates interested in a postdoc position should hold a doctorate degree in biomedical engineering, polymer chemistry, or materials science and engineering, and have a demonstrated record of relevant research accomplishments as evidenced by their ADPKD CLASSIFICATION classification of typical adpkd calculator end user license agreement. important legal notice to all users: carefully read the following legal agreement before you start using the classification of typical adpkd calculator web-based application (the "web-based application"). POLYARTERITIS NODOSA CLINICAL TRIALS The purpose of this clinical trial is to determine if low dose naltrexone is effective in improving health-related quality of life (HRQoL) among patients with vasculitis. Although it is a pilot study, a placebo-controlled component is used because of the prominent placebo group effect seen in studies with self-reported subjective

outcomes.

KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

DAVID F. KALLMES, M.D. The research interests of David F. Kallmes, M.D., center on advancing the minimally invasive treatment options for patients with intracranial saccular aneurysms. Dr. Kallmes' preclinical laboratory is developing and testing multiple improvements to the microcoil technology used to treat this WILSON I. GONSALVES, M.D. Wilson I. Gonsalves, M.D., focuses his research on understanding the cellular metabolism of malignant plasma cells in diseases such as multiple myeloma by employing a variety of systems biology techniques in an integrated fashion. Dr. Gonsalves is also interested in enhancing the supportive care of patients with plasma cell disorders

by

VERONIQUE BELZIL, PH.D., M.S. Veronique Belzil, Ph.D., M.S., works on developing individualized approaches to treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and other related neurodegenerative diseases. Her laboratory aims to discover and characterize genetic, epigenetic and transcriptional changes GANG ZHENG, M.D., PH.D. Gang Zheng, M.D., Ph.D., is board certified in both molecular pathology and hematopathology. His clinical and research interests include implementing cutting-edge molecular technologies in clinical diagnostics of cancer and applying data mining to integrate genomic, morphologic and clinical data for OVERVIEW - MAYO CLINIC RESEARCH CORE FACILITIES - MAYO Mayo Clinic Research Core Facilities are centralized, shared research resources that provide access to instruments, technologies, testing and services. They provide expert technical and consultative services to investigators engaged in basic science research and clinical trials. These facilities A STUDY TO OPTIMIZE PATIENT SELECTION AND OUTCOMES IN Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices. Medical records

research — uses

STUDY TO EVALUATE THE EFFECTIVENESS AND SAFETY OF About this study. The primary objective of this study is to evaluate whether remdesivir (RDV, GS-5734â„¢) reduces the composite risk of death or invasive mechanical ventilation (IMV) through Day 29 in participants with severely reduced kidney function who are

MICROBIOME PROGRAM

Microbiome Program. The invention of the microscope long ago allowed scientists to understand how bacteria can cause and transmit infections in humans. Now, using genomic sequencing, researchers are discovering that communities of bacteria inside and on every person's body, known collectively as the human microbiome, do much more for

people

(VOYAGER) STUDY OF AVAPRITINIB VS REGORAFENIB IN PATIENTS About this study. This is an open-label, randomized, Phase 3 study in patients with locally advanced unresectable or metastatic GIST (advanced GIST) of avapritinib (also known as BLU-285) versus regorafenib in patients previously treated with imatinib and 1 or 2

other TKIs.

PHARMACOGENOMICS FOR PATIENTS These types of questions might be answered by pharmacogenomics (PGx), which is the study of how genes affect the body's response to medications. Emerging tools for PGx testing, also referred to as drug-gene testing, can guide your doctor to tailor your medications based on your genes. This is key to personalizing your health care. GENOMIC SEQUENCING: TAPESTRY STUDY You can also contact the Center for Individualized Medicine for information on clinical studies and trials.. Support individualized medicine research. Generous donors and benefactors make studies like Tapestry possible. Your gift to the Center for Individualized Medicine supports translational research in areas such as genomic sequencing to enhance the electronic health record. SPINAL STENOSIS CLINICAL TRIALS A Study Comparing Either Cervical Spine, Head, Temporal Bone or Vasculature Treated with Metallic Implants Imaged with CT or MRI or Cerebral Angiogram to a MRI Zero Echo Time (ZTE) MRI Sequence Rochester, MN . The purpose of this study is to demonstrate the use of 3D ZTE imaging of the cervical spine to assess osseous neural foraminal stenosis and directly compare it to CT. KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

EDUARDO E. BENARROCH, M.D. The research of Eduardo E. Benarroch, M.D., is focused on alterations of neurochemically defined neuronal groups in the brainstem and hypothalamus that control homeostasis in neurodegenerative disorders, such as multiple system atrophy and Lewy body OVERVIEW - MAYO CLINIC RESEARCH CORE FACILITIES - MAYO Mayo Clinic Research Core Facilities are centralized, shared research resources that provide access to instruments, technologies, testing and services. They provide expert technical and consultative services to investigators engaged in basic science research and clinical trials. These facilities

POSTDOC CAREERS

Postdoc Careers. Our lab offers positions for postdoctoral research fellows to work on research projects alongside Dr. Lu and the lab team. Candidates interested in a postdoc position should hold a doctorate degree in biomedical engineering, polymer chemistry, or materials science and engineering, and have a demonstrated record of relevant research accomplishments as evidenced by (VOYAGER) STUDY OF AVAPRITINIB VS REGORAFENIB IN PATIENTS About this study. This is an open-label, randomized, Phase 3 study in patients with locally advanced unresectable or metastatic GIST (advanced GIST) of avapritinib (also known as BLU-285) versus regorafenib in patients previously treated with imatinib and 1 or 2

other TKIs.

GEOFFREY (GEOFFREY B.) B. THOMPSON, M.D. Resident - General Surgery Mayo Graduate School of Medicine, Mayo Clinic College of Medicine. Fellow - Visiting Clinical Fellow in Pathology Brigham and Women's Hospital, Harvard Medical School. Resident - Anatomic Pathlolgy University of Massachusetts Medical

Center. Resident -

ADPKD CLASSIFICATION classification of typical adpkd calculator end user license agreement. important legal notice to all users: carefully read the following legal agreement before you start using the classification of typical adpkd calculator web-based application (the "web-based application"). KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

WILSON I. GONSALVES, M.D. Wilson I. Gonsalves, M.D., focuses his research on understanding the cellular metabolism of malignant plasma cells in diseases such as multiple myeloma by employing a variety of systems biology techniques in an integrated fashion. Dr. Gonsalves is also interested in enhancing the supportive care of patients with plasma cell disorders

by

BRADLEY F. BOEVE, M.D. The clinical and research interests of Bradley F. Boeve, M.D., include normal aging, neurodegenerative disorders that cause cognitive impairment or dementia, neurogenetics, prion disorders, and neurological sleep disorders. Specific disorders of interest include: mild cognitive impairment, Alzheimer FERNANDO (FERNANDO C.) C. FERVENZA, M.D., PH.D. SUMMARY. Fernando C. Fervenza, M.D., Ph.D., is the director of the Nephrology Collaborative Group. Through his work with the Nephrology Collaborative Group, Dr. Fervenza pursues patient-oriented research projects in the area of parenchymal renal diseases, with an aim of bringing new bench research discoveries to the bedside treatment of patients with these diseases. SEAN J. PITTOCK, M.D. Sean J. Pittock, M.D., is the director of Mayo Clinic's Center for Multiple Sclerosis and Autoimmune Neurology and of Mayo's Neuroimmunology Research Laboratory. Dr. Pittock's clinical and laboratory expertise lies in modifying, for clinical application, the antibody assays developed by the Neuroimmunology Research Laboratory. OVERVIEW - MAYO CLINIC RESEARCH CORE FACILITIES - MAYO Mayo Clinic Research Core Facilities are centralized, shared research resources that provide access to instruments, technologies, testing and services. They provide expert technical and consultative services to investigators engaged in basic science research and clinical trials. These facilities

POSTDOC CAREERS

Postdoc Careers. Our lab offers positions for postdoctoral research fellows to work on research projects alongside Dr. Lu and the lab team. Candidates interested in a postdoc position should hold a doctorate degree in biomedical engineering, polymer chemistry, or materials science and engineering, and have a demonstrated record of relevant research accomplishments as evidenced by (VOYAGER) STUDY OF AVAPRITINIB VS REGORAFENIB IN PATIENTS About this study. This is an open-label, randomized, Phase 3 study in patients with locally advanced unresectable or metastatic GIST (advanced GIST) of avapritinib (also known as BLU-285) versus regorafenib in patients previously treated with imatinib and 1 or 2

other TKIs.

GEOFFREY (GEOFFREY B.) B. THOMPSON, M.D. Resident - General Surgery Mayo Graduate School of Medicine, Mayo Clinic College of Medicine. Fellow - Visiting Clinical Fellow in Pathology Brigham and Women's Hospital, Harvard Medical School. Resident - Anatomic Pathlolgy University of Massachusetts Medical

Center. Resident -

ADPKD CLASSIFICATION classification of typical adpkd calculator end user license agreement. important legal notice to all users: carefully read the following legal agreement before you start using the classification of typical adpkd calculator web-based application (the "web-based application"). KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

WILSON I. GONSALVES, M.D. Wilson I. Gonsalves, M.D., focuses his research on understanding the cellular metabolism of malignant plasma cells in diseases such as multiple myeloma by employing a variety of systems biology techniques in an integrated fashion. Dr. Gonsalves is also interested in enhancing the supportive care of patients with plasma cell disorders

by

BRADLEY F. BOEVE, M.D. The clinical and research interests of Bradley F. Boeve, M.D., include normal aging, neurodegenerative disorders that cause cognitive impairment or dementia, neurogenetics, prion disorders, and neurological sleep disorders. Specific disorders of interest include: mild cognitive impairment, Alzheimer FERNANDO (FERNANDO C.) C. FERVENZA, M.D., PH.D. SUMMARY. Fernando C. Fervenza, M.D., Ph.D., is the director of the Nephrology Collaborative Group. Through his work with the Nephrology Collaborative Group, Dr. Fervenza pursues patient-oriented research projects in the area of parenchymal renal diseases, with an aim of bringing new bench research discoveries to the bedside treatment of patients with these diseases. SEAN J. PITTOCK, M.D. Sean J. Pittock, M.D., is the director of Mayo Clinic's Center for Multiple Sclerosis and Autoimmune Neurology and of Mayo's Neuroimmunology Research Laboratory. Dr. Pittock's clinical and laboratory expertise lies in modifying, for clinical application, the antibody assays developed by the Neuroimmunology Research Laboratory. A STUDY TO OPTIMIZE PATIENT SELECTION AND OUTCOMES IN Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices. Medical records

research — uses

CENTER FOR INDIVIDUALIZED MEDICINE Individualized Medicine Education for Researchers. Mayo Clinic offers individualized medicine education for researchers at all stages of their careers, including graduate-level courses, a clinician-investigator program and career development awards. STUDY TO EVALUATE THE EFFECTIVENESS AND SAFETY OF About this study. The primary objective of this study is to evaluate whether remdesivir (RDV, GS-5734â„¢) reduces the composite risk of death or invasive mechanical ventilation (IMV) through Day 29 in participants with severely reduced kidney function who are (VOYAGER) STUDY OF AVAPRITINIB VS REGORAFENIB IN PATIENTS About this study. This is an open-label, randomized, Phase 3 study in patients with locally advanced unresectable or metastatic GIST (advanced GIST) of avapritinib (also known as BLU-285) versus regorafenib in patients previously treated with imatinib and 1 or 2

other TKIs.

LUNG REGENERATION

Regenerative medicine has the potential to provide innovative new therapies for people with lung diseases, including chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, cystic fibrosis, pulmonary arterial hypertension and bronchiolitis obliterans.. Currently, end-stage lung disease is treated with a gamut of medications or ultimately, lung transplantation. KNEE CARTILAGE RESTORATION Knee Cartilage Restoration. Mayo Clinic surgeons use the latest surgical and nonsurgical treatment options to restore articular cartilage in the knee. Mayo Clinic's Sports Medicine Research team investigates cutting-edge techniques by participating in several multicenter clinical trials. Faculty members collaborating on research

related to knee

FOCAL LASER ABLATION OF PROSTATE CANCER TUMORS Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices. Medical records

research — uses

PROSTATE BIOPSIES DOWN, COMPLICATIONS UP While absolute rates of biopsy and post-biopsy complications have decreased after several benchmark prostate-specific antigen (PSA) screening publications, the relative risk for each patient continues to increase, according to a new study by Mayo Clinic researchers.. The study is the largest to examine the impact of PSA screening trials and revised PSA screening guidelines on rates of prostate CARLOS D. PINHEIRO NETO, M.D., PH.D. The research of Carlos D. Pinheiro Neto, M.D., Ph.D., is based on the development of innovative surgical techniques to improve outcomes of patients who undergo endoscopic nasal, sinus or skull base surgery. His work in the anatomy laboratory aims to enhance the description of

key anatomical

LAPRINCESS C. BREWER, M.D., M.P.H. LaPrincess C. Brewer, M.D., M.P.H., has a primary research focus in developing strategies to reduce and ultimately eliminate cardiovascular disease health disparities in racial and ethnic minority populations and in underserved communities through health promotion and community-based participatory Skip to site navigation Skip to Content

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Faculty

SAAD J. KENDERIAN, M.B., CH.B.

LOCATION

Rochester, Minnesota

CONTACT

Kenderian.Saad@mayo.edu Clinical Profile

SUMMARY

The research of Saad J. Kenderian, M.B., Ch.B., and his team is centered on the development and optimization of novel-engineered T cell therapy approaches for the treatment of cancer. Using the immune system to treat cancer (immunotherapy) has emerged as a potent and potentially curative modality. The recent success of engineered T cell therapy highlights the potential for this technology as a new pillar in the treatment of hematological malignancies.

FOCUS AREAS

* MODIFIED CELLULAR THERAPIES. The major focus of Dr. Kenderian's research team is to develop safe and efficient next-generation modified cellular products and to extend their applications to the treatment of different hematological and solid tumors. * RESISTANCE TO IMMUNOTHERAPY. Despite the reported success of immunotherapy and engineered T cell therapy in the treatment of hematological malignancies, a significant percentage of patients do not respond. A key area of Dr. Kenderian's laboratory is to identify mechanisms of resistance to immunotherapy in chronic lymphocytic leukemia and other hematological cancers. * ALLOGENEIC HEMATOPOIETIC CELL TRANSPLANTATION. Allogeneic transplantation remains the only potentially curative option in a number of hematological malignancies but is associated with high morbidity and mortality due to the development of graft-versus-host disease. Dr. Kenderian's laboratory is therefore investigating modified products to enhance the safety of allogeneic transplantation. * COMBINATION IMMUNOTHERAPY. In order to enhance the efficacy and safety of modified T cell therapy, Dr. Kenderian's laboratory is testing the optimal development of combinatorial approaches with signal inhibitors, small molecule approach and other immunotherapeutic

approaches.

SIGNIFICANCE TO PATIENT CARE Dr. Kenderian's team is focused on developing new, effective and safe immunotherapeutic options for patients with relapsed and refractory hematological malignancies. His team collaborates with other teams and centers within Mayo Clinic and has several research efforts in early-phase clinical trials. PROFESSIONAL HIGHLIGHTS * Recipient, Gilead Research Scholar Award, Gilead Sciences, 2019 * Recipient, New Investigator Award, Mayo Clinic Department of

Medicine, 2018

* Recipient, Young Investigator Award, National Comprehensive Cancer

Network, 2017

* Recipient, Biotechnology/Biobusiness Award, Regenerative Medicine

Minnesota, 2017

* Recipient, Richard M. Schulze Family Foundation Award in Cancer Research, Mayo Clinic Cancer Center, 2017 * Recipient, Best abstract award, American Society for Blood and Marrow Transplantation, 2017 * Recipient, Plenary presentation award, American Society for Blood and Marrow Transplantation, 2015-2017 * Recipient, Alexandra J. Kefalides Memorial Award, Abramson Cancer Center, University of Pennsylvania, 2014 * Recipient, Mayo Clinic Scholar award, 2013 * Recipient, Hematology/Oncology Award, Outstanding Achievement,

Mayo Clinic, 2013

* Recipient, The Consummate Physician Award, McLaren Hospital, Michigan State University, 2009 * Recipient, The Team Leader Award, McLaren Hospital, Michigan State

University, 2009

* Recipient, Outstanding Resident of the Year Award, McLaren Hospital, Michigan State University, 2007 and 2008

CLINICAL STUDIES

See my clinical studies

PUBLICATIONS

See my publications

PROFESSIONAL DETAILS

PRIMARY APPOINTMENT

* Consultant, Division of Hematology, Department of Internal Medicine

JOINT APPOINTMENT

* Consultant, Department of Immunology * Consultant, Department of Molecular Medicine

ACADEMIC RANK

* Assistant Professor of Immunology * Assistant Professor of Medicine * Assistant Professor of Oncology

EDUCATION

* MAYO CLINIC SCHOLAR - IMMUNOTHERAPY, CHIMERIC ANTIGEN RECEPTOR T CELL THERAPY University of Pennsylvania School of Medicine * CHIEF FELLOW - HEMATOLOGY AND MEDICAL ONCOLOGY Mayo Clinic, School of Graduate Medical Education * FELLOW - HEMATOLOGY, MEDICAL ONCOLOGY, BONE MARROW TRANSPLANTATION Mayo Clinic, School of Graduate Medical Education * CHIEF MEDICAL RESIDENT McLaren Regional Medical Center, Michigan

State University

* RESIDENCY - INTERNAL MEDICINE McLaren Regional Medical Center, Michigan State University * ROTATING INTERNSHIP University of Baghdad School of Medicine * MB CHB University of Baghdad School of Medicine

RELATED LINKS

AREAS OF RESEARCH

* Mayo Clinic Cancer Center — Research * Center for Regenerative Medicine * Center for Immunology and Immune Therapies * David F. and Margaret T. Grohne Cancer Immunology and Immunotherapy Program * Immunology Research * Center for Individualized Medicine * Lymphoma Epidemiology: James R. Cerhan * T Cell Engineering: Saad J. Kenderian MORE ABOUT RESEARCH AT MAYO CLINIC

* Research Faculty

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BIO-20206512

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