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WELCOME TO THE ROME FOUNDATION Our mission is to improve the lives of people with Disorders of Gut-Brain Interaction. The Rome Foundation is an independent not-for-profit organization dedicated to supporting the creation of scientific data and educational information to assist in diagnosing and treating Disorders of Gut-Brain Interaction (DGBIs), formerly called Functional Gastrointestinal Disorders (FGIDs).

QUESTIONNAIRES

Name of Instrument Description of Instrument Non-English Versions Key Citations; Rome IV Book Rome IV : Two volume textbook of all Rome IV content that contains appendices with

ROME IV CRITERIA

Diagnostic criteria. New, or worsening, symptoms of constipation when initiating, changing, or increasing opioid therapy, that must include two or more of the following: Straining during more than ¼ (25%) of defecations. Lumpy or hard stools (Bristol Stool Form GUIDELINES - ROME FOUNDATION The Rome Foundation itself will be preparing official versions of its material in several central languages. When completed, those versions will be the officially sanctioned versions of the Rome Foundation and should be used in all cases. Translation into other languages will have to be conducted in accordance with the enclosed guidelines.

GASTROPSYCH

The Rome GastroPsych group is excited to announce the handbook for Mental Health Professionals in Psychogastroenterology is now available online! Co-written by Dr. Laurie Keefer, PhD, Rome Board member and co-director of the Rome Psychogastro Committee, this handbook is an excellent resource for all mental health professionals working with gastroenterology patients. DIET IN IRRITABLE BOWEL SYNDROME (IBS) The most frequently used diets for IBS include traditional dietary advice, a lactose-free diet, a diet low in fermentable carbohydrates, i.e., the low fermentable oligo-, di-, monosaccharides and polyols (FODMAP), and a gluten-free diet (GFD). It is also quite common that patients use a “trial and error” approach to avoid food items that MENTAL HEALTH PROFESSIONALS IN PSYCHOGASTROENTEROLOGY IN The Rome GastroPsych group is excited to announce that the handbook for Mental Health Professionals in Psychogastroenterology in now available online! Co-written by Dr. Laurie Keefer, PhD, Rome Board member and co-director of the Rome Psychogastro Committee, this handbook is an excellent resource for all mental health professionals

working with

IMPROVING PATIENT-PROVIDER RELATIONSHIPS TO IMPROVE HEALTH NARRATIVE REVIEW Fasiha Kanwal, Section Editor Improving Patient-Provider Relationships to Improve Health Care Douglas A. Drossman*,‡,§,jj and Johannah Ruddy*,jj *Center for Education and Practice of Biopsychosocial Care, DrossmanCare, Durham, North Carolina; ‡UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North

Carolina

CENTRALLY MEDIATED DISORDERS OF GASTROINTESTINAL PAIN Centrally Mediated Disorders of Gastrointestinal Pain Laurie Keefer,1 Douglas A. Drossman,2 Elspeth Guthrie,3 Magnus Simrén,4 Kirsten Tillisch,5 Kevin Olden,6 and Peter J. Whorwell7 1Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; 2Center for Functional GI and Motility Disorders, University of North Carolina and Center for Education and Practice of CHILDHOOD FUNCTIONAL GASTROINTESTINAL DISORDERS: NEONATE Childhood Functional Gastrointestinal Disorders: Neonate/Toddler Marc A. Benninga,1,* Samuel Nurko,2,* Christophe Faure,3 Paul E. Hyman,4 Ian St. James Roberts,5 and Neil L. Schechter6 1Pediatric Gastroenterology, Emma Children’s Hospital, Academic Medical Center, Amsterdam, The Netherlands; 2Center for Motility and Functional Gastrointestinal Disorders, Boston Children’s Hospital, Boston WELCOME TO THE ROME FOUNDATION Our mission is to improve the lives of people with Disorders of Gut-Brain Interaction. The Rome Foundation is an independent not-for-profit organization dedicated to supporting the creation of scientific data and educational information to assist in diagnosing and treating Disorders of Gut-Brain Interaction (DGBIs), formerly called Functional Gastrointestinal Disorders (FGIDs).

QUESTIONNAIRES

Name of Instrument Description of Instrument Non-English Versions Key Citations; Rome IV Book Rome IV : Two volume textbook of all Rome IV content that contains appendices with

ROME IV CRITERIA

Diagnostic criteria. New, or worsening, symptoms of constipation when initiating, changing, or increasing opioid therapy, that must include two or more of the following: Straining during more than ¼ (25%) of defecations. Lumpy or hard stools (Bristol Stool Form GUIDELINES - ROME FOUNDATION The Rome Foundation itself will be preparing official versions of its material in several central languages. When completed, those versions will be the officially sanctioned versions of the Rome Foundation and should be used in all cases. Translation into other languages will have to be conducted in accordance with the enclosed guidelines.

GASTROPSYCH

The Rome GastroPsych group is excited to announce the handbook for Mental Health Professionals in Psychogastroenterology is now available online! Co-written by Dr. Laurie Keefer, PhD, Rome Board member and co-director of the Rome Psychogastro Committee, this handbook is an excellent resource for all mental health professionals working with gastroenterology patients. DIET IN IRRITABLE BOWEL SYNDROME (IBS) The most frequently used diets for IBS include traditional dietary advice, a lactose-free diet, a diet low in fermentable carbohydrates, i.e., the low fermentable oligo-, di-, monosaccharides and polyols (FODMAP), and a gluten-free diet (GFD). It is also quite common that patients use a “trial and error” approach to avoid food items that MENTAL HEALTH PROFESSIONALS IN PSYCHOGASTROENTEROLOGY IN The Rome GastroPsych group is excited to announce that the handbook for Mental Health Professionals in Psychogastroenterology in now available online! Co-written by Dr. Laurie Keefer, PhD, Rome Board member and co-director of the Rome Psychogastro Committee, this handbook is an excellent resource for all mental health professionals

working with

IMPROVING PATIENT-PROVIDER RELATIONSHIPS TO IMPROVE HEALTH NARRATIVE REVIEW Fasiha Kanwal, Section Editor Improving Patient-Provider Relationships to Improve Health Care Douglas A. Drossman*,‡,§,jj and Johannah Ruddy*,jj *Center for Education and Practice of Biopsychosocial Care, DrossmanCare, Durham, North Carolina; ‡UNC Center for Functional GI and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, North

Carolina

CENTRALLY MEDIATED DISORDERS OF GASTROINTESTINAL PAIN Centrally Mediated Disorders of Gastrointestinal Pain Laurie Keefer,1 Douglas A. Drossman,2 Elspeth Guthrie,3 Magnus Simrén,4 Kirsten Tillisch,5 Kevin Olden,6 and Peter J. Whorwell7 1Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; 2Center for Functional GI and Motility Disorders, University of North Carolina and Center for Education and Practice of CHILDHOOD FUNCTIONAL GASTROINTESTINAL DISORDERS: NEONATE Childhood Functional Gastrointestinal Disorders: Neonate/Toddler Marc A. Benninga,1,* Samuel Nurko,2,* Christophe Faure,3 Paul E. Hyman,4 Ian St. James Roberts,5 and Neil L. Schechter6 1Pediatric Gastroenterology, Emma Children’s Hospital, Academic Medical Center, Amsterdam, The Netherlands; 2Center for Motility and Functional Gastrointestinal Disorders, Boston Children’s Hospital, Boston Q & A MDCP 3RD EDITION Third Edition MDCP 5/21/2021. Dr. Drossman and Johannah walk you through a couple of clinical cases from the 3rd edition of the Multidimensional Clinical Profile to highlight how Rome teaches doctors to diagnose and treat patients with DGBI. DIET IN IRRITABLE BOWEL SYNDROME (IBS) The most frequently used diets for IBS include traditional dietary advice, a lactose-free diet, a diet low in fermentable carbohydrates, i.e., the low fermentable oligo-, di-, monosaccharides and polyols (FODMAP), and a gluten-free diet (GFD). It is also quite common that patients use a “trial and error” approach to avoid food items that EFFECTS OF TRAUMA AND ABUSE ON THE BRAIN: BEFORE AND AFTER My research shows that there is a physiological and structural change in the brain that causes more severe pain in victims of abuse and trauma. But my research also contains proof of a reason to be hopeful: brain scans of patients taken after treatment prove that these changes are reversible. If you or a loved one is suffering, I encourage you BLOATING AND DISTENSION: WHAT’S THE DIFFERENCE? Bloating and Distension: What’s the Difference? When a person describes the feeling of bloating, they may or may not be aware of an increase in abdominal girth. The former is a symptom and the latter is a visible swelling and feeling of tightness of their skin or clothing along with discomfort. Often, patients will describe this as if a DISORDERS OF GUT-BRAIN INTERACTION IN PEDIATRICS: A FEW Disorders of gut-brain interaction (DGBI) are common in the pediatric population. DGBIs are also known as functional gastrointestinal disorders (FGIDs). Although pediatric DGBIs are usually considered “benign” problems, parents are worried, the child may be in distress, and the practitioners are often pressured to order tests to

avoid

CHILDHOOD FUNCTIONAL GASTROINTESTINAL DISORDERS: CHILD Childhood Functional Gastrointestinal Disorders: Child/ Adolescent Jeffrey S. Hyams,1,* Carlo Di Lorenzo,2,* Miguel Saps,2 Robert J. Shulman,3 Annamaria Staiano,4 and Miranda van Tilburg5 1Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children’sMedicalCenter,Hartford, Connecticut; 2Division of Digestive Diseases, Hepatology, and Nutrition, Nationwide Children’s

BOWEL DISORDERS

Bowel Disorders Brian E. Lacy,1 Fermín Mearin,2 Lin Chang,3 William D. Chey,4 Anthony J. Lembo,5 Magnus Simren,6 and Robin Spiller7 1Division of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; 2Institute of Functional and Motor Digestive Disorders, Centro Médico Teknon, Barcelona, Spain; 3David Geffen School of Medicine at THE INTESTINAL MICROENVIRONMENT AND FUNCTIONAL The Intestinal Microenvironment and Functional Gastrointestinal Disorders Giovanni Barbara,1 Christine Feinle-Bisset,2 Uday C. Ghoshal,3 Javier Santos,4 Stepen J. Vanner,5 Nathalie Vergnolle,6 Erwin G. Zoetendal,7 and Eamonn M. Quigley8 1Department of Medical and Surgical Sciences, School of Medicine, University of Bologna, Italy; 2University of Adelaide GASTROENTEROLOGY 2016;150:1262 SECTION I: FGIDS Early to Mid-20th Century: Observations of Gut and Brain Behavior (1900–1959) Beaumont set the stage for further investigations of the effects of emotion on gastrointestinal function. GALLBLADDER AND SPHINCTER OF ODDI DISORDERS Gallbladder and Sphincter of Oddi Disorders Peter B. Cotton,1 Grace H. Elta,2 C. Ross Carter,3 Pankaj Jay Pasricha,4 Enrico S. Corazziari5 1Medical University of South Carolina, Charleston, South Carolina; 2University of Michigan, Ann Arbor, Michigan; 3Glasgow Royal Infirmary, Glasgow, Scotland; 4Johns Hopkins School of Medicine, Baltimore, Maryland; and 5Universita La Sapienza, WELCOME TO THE ROME FOUNDATION Our mission is to improve the lives of people with Disorders of Gut-Brain Interaction. The Rome Foundation is an independent not-for-profit organization dedicated to supporting the creation of scientific data and educational information to assist in diagnosing and treating Disorders of Gut-Brain Interaction (DGBIs), formerly called Functional Gastrointestinal Disorders (FGIDs).

QUESTIONNAIRES

Name of Instrument Description of Instrument Non-English Versions Key Citations; Rome IV Book Rome IV : Two volume textbook of all Rome IV content that contains appendices with PEDIATRIC - ROME FOUNDATIONPEDIATRICS ROME NYROME MEDICAL GROUP ROME

NY

Rome IV Pediatric Functional Gastrointestinal Disorders – Disorders of Gut-Brain Interaction (First Edition). The field of pediatric FGIDs has grown over the last two decades, and for this reason we have decided to publish a separate book on pediatric FGIDs, which

ROME IV CRITERIA

Diagnostic criteria. New, or worsening, symptoms of constipation when initiating, changing, or increasing opioid therapy, that must include two or more of the following: Straining during more than ¼ (25%) of defecations. Lumpy or hard stools (Bristol Stool Form GUIDELINES - ROME FOUNDATION The Rome Foundation itself will be preparing official versions of its material in several central languages. When completed, those versions will be the officially sanctioned versions of the Rome Foundation and should be used in all cases. Translation into other languages will have to be conducted in accordance with the enclosed guidelines.

GASTROPSYCH

The Rome GastroPsych group is excited to announce the handbook for Mental Health Professionals in Psychogastroenterology is now available online! Co-written by Dr. Laurie Keefer, PhD, Rome Board member and co-director of the Rome Psychogastro Committee, this handbook is an excellent resource for all mental health professionals working with gastroenterology patients. EFFECTS OF TRAUMA AND ABUSE ON THE BRAIN: BEFORE AND AFTEREFFECTS OF EMOTIONAL TRAUMA ON THE BRAIN My research shows that there is a physiological and structural change in the brain that causes more severe pain in victims of abuse and trauma. But my research also contains proof of a reason to be hopeful: brain scans of patients taken after treatment prove that these changes are reversible. If you or a loved one is suffering, I encourage you GALLBLADDER AND SPHINCTER OF ODDI DISORDERS Gallbladder and Sphincter of Oddi Disorders Peter B. Cotton,1 Grace H. Elta,2 C. Ross Carter,3 Pankaj Jay Pasricha,4 Enrico S. Corazziari5 1Medical University of South Carolina, Charleston, South Carolina; 2University of Michigan, Ann Arbor, Michigan; 3Glasgow Royal Infirmary, Glasgow, Scotland; 4Johns Hopkins School of Medicine, Baltimore, Maryland; and 5Universita La Sapienza, BLOATING AND DISTENSION: WHAT’S THE DIFFERENCE? Bloating and Distension: What’s the Difference? When a person describes the feeling of bloating, they may or may not be aware of an increase in abdominal girth. The former is a symptom and the latter is a visible swelling and feeling of tightness of their skin or clothing along with discomfort. Often, patients will describe this as if a CHILDHOOD FUNCTIONAL GASTROINTESTINAL DISORDERS: CHILD Childhood Functional Gastrointestinal Disorders: Child/ Adolescent Jeffrey S. Hyams,1,* Carlo Di Lorenzo,2,* Miguel Saps,2 Robert J. Shulman,3 Annamaria Staiano,4 and Miranda van Tilburg5 1Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children’sMedicalCenter,Hartford, Connecticut; 2Division of Digestive Diseases, Hepatology, and Nutrition, Nationwide Children’s WELCOME TO THE ROME FOUNDATION Our mission is to improve the lives of people with Disorders of Gut-Brain Interaction. The Rome Foundation is an independent not-for-profit organization dedicated to supporting the creation of scientific data and educational information to assist in diagnosing and treating Disorders of Gut-Brain Interaction (DGBIs), formerly called Functional Gastrointestinal Disorders (FGIDs).

QUESTIONNAIRES

Name of Instrument Description of Instrument Non-English Versions Key Citations; Rome IV Book Rome IV : Two volume textbook of all Rome IV content that contains appendices with PEDIATRIC - ROME FOUNDATIONPEDIATRICS ROME NYROME MEDICAL GROUP ROME

NY

Rome IV Pediatric Functional Gastrointestinal Disorders – Disorders of Gut-Brain Interaction (First Edition). The field of pediatric FGIDs has grown over the last two decades, and for this reason we have decided to publish a separate book on pediatric FGIDs, which

ROME IV CRITERIA

Diagnostic criteria. New, or worsening, symptoms of constipation when initiating, changing, or increasing opioid therapy, that must include two or more of the following: Straining during more than ¼ (25%) of defecations. Lumpy or hard stools (Bristol Stool Form GUIDELINES - ROME FOUNDATION The Rome Foundation itself will be preparing official versions of its material in several central languages. When completed, those versions will be the officially sanctioned versions of the Rome Foundation and should be used in all cases. Translation into other languages will have to be conducted in accordance with the enclosed guidelines.

GASTROPSYCH

The Rome GastroPsych group is excited to announce the handbook for Mental Health Professionals in Psychogastroenterology is now available online! Co-written by Dr. Laurie Keefer, PhD, Rome Board member and co-director of the Rome Psychogastro Committee, this handbook is an excellent resource for all mental health professionals working with gastroenterology patients. EFFECTS OF TRAUMA AND ABUSE ON THE BRAIN: BEFORE AND AFTEREFFECTS OF EMOTIONAL TRAUMA ON THE BRAIN My research shows that there is a physiological and structural change in the brain that causes more severe pain in victims of abuse and trauma. But my research also contains proof of a reason to be hopeful: brain scans of patients taken after treatment prove that these changes are reversible. If you or a loved one is suffering, I encourage you GALLBLADDER AND SPHINCTER OF ODDI DISORDERS Gallbladder and Sphincter of Oddi Disorders Peter B. Cotton,1 Grace H. Elta,2 C. Ross Carter,3 Pankaj Jay Pasricha,4 Enrico S. Corazziari5 1Medical University of South Carolina, Charleston, South Carolina; 2University of Michigan, Ann Arbor, Michigan; 3Glasgow Royal Infirmary, Glasgow, Scotland; 4Johns Hopkins School of Medicine, Baltimore, Maryland; and 5Universita La Sapienza, BLOATING AND DISTENSION: WHAT’S THE DIFFERENCE? Bloating and Distension: What’s the Difference? When a person describes the feeling of bloating, they may or may not be aware of an increase in abdominal girth. The former is a symptom and the latter is a visible swelling and feeling of tightness of their skin or clothing along with discomfort. Often, patients will describe this as if a CHILDHOOD FUNCTIONAL GASTROINTESTINAL DISORDERS: CHILD Childhood Functional Gastrointestinal Disorders: Child/ Adolescent Jeffrey S. Hyams,1,* Carlo Di Lorenzo,2,* Miguel Saps,2 Robert J. Shulman,3 Annamaria Staiano,4 and Miranda van Tilburg5 1Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children’sMedicalCenter,Hartford, Connecticut; 2Division of Digestive Diseases, Hepatology, and Nutrition, Nationwide Children’s ABOUT THE ROME FOUNDATION The Rome Foundation is an independent not for profit 501(c) 3 organization that provides support for activities designed to create scientific data and educational information to assist in the diagnosis and treatment of Disorders of Gut Brain Interactions (DGBIs).Our mission is to improve the lives of people with functional GI disorders. Over the last 20 years, the Rome organization has sought PEDIATRIC - ROME FOUNDATION Rome IV Pediatric Functional Gastrointestinal Disorders – Disorders of Gut-Brain Interaction (First Edition). The field of pediatric FGIDs has grown over the last two decades, and for this reason we have decided to publish a separate book on pediatric FGIDs, which is EFFECTS OF TRAUMA AND ABUSE ON THE BRAIN: BEFORE AND AFTER In other words, the pain is real. It is not all in the patient’s head and it’s not a psychiatric condition. My research shows that there is a physiological and structural change in the brain that causes more severe pain in victims of abuse and trauma. WHAT’S NEW FOR ROME IV The Rome Foundation has sought to maintain a strong knowledge base in the field and that has occurred mainly with revisions every 6-10 years. Rome IV updates include a redefinition of FGIDs and diagnostic criteria, addition of newly recognized disorders, and major changes in criteria for existing disorders (1). BRAIN-GUT PSYCHOTHERAPIES WORKING TEAM This Rome Foundation Working Team will provide an authoritative document on BGPs from internationally recognized experts, including recommendations for what works for whom. We will also highlight some of the promising areas for future research. Working Team Members: Laurie Keefer, PhD-Chair. Mount Sinai (New York City, USA) Douglas

Drossman, MD.

BLOATING AND DISTENSION: WHAT’S THE DIFFERENCE? Bloating and Distension: What’s the Difference? When a person describes the feeling of bloating, they may or may not be aware of an increase in abdominal girth. The former is a symptom and the latter is a visible swelling and feeling of tightness of their skin or clothing along with discomfort. Often, patients will describe this as if a

PEDIATRIC COMMITTEE

Pediatric Committee. The Rome Foundation Pediatric Committee provides the structure to foster and further develop the pediatric GI components of the Rome foundation that will cover aspects of education, research and patient care. Since the initial development of the pediatric Rome criteria in 1999 there has been a major increase in

their

BOWEL DISORDERS

Bowel Disorders Brian E. Lacy,1 Fermín Mearin,2 Lin Chang,3 William D. Chey,4 Anthony J. Lembo,5 Magnus Simren,6 and Robin Spiller7 1Division of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; 2Institute of Functional and Motor Digestive Disorders, Centro Médico Teknon, Barcelona, Spain; 3David Geffen School of Medicine at MENTAL HEALTH PROFESSIONALS IN PSYCHOGASTROENTEROLOGY IN The Rome GastroPsych group is excited to announce that the handbook for Mental Health Professionals in Psychogastroenterology in now available online! Co-written by Dr. Laurie Keefer, PhD, Rome Board member and co-director of the Rome Psychogastro Committee, this handbook is an excellent resource for all mental health professionals

working with

KEN HEATON AWARD

Giada De Palma, PhD Title: “Microbiota and host determinants of behavioural phenotype in maternally separated mice.” Nature Communications 2015; 6; 7735. doi: 10.1038/ncomms8735. PMID: 26218677. This article was cited 35 times. Dr. Giada De Palma is a research

associate with

WELCOME TO THE ROME FOUNDATION Our mission is to improve the lives of people with Disorders of Gut-Brain Interaction. The Rome Foundation is an independent not-for-profit organization dedicated to supporting the creation of scientific data and educational information to assist in diagnosing and treating Disorders of Gut-Brain Interaction (DGBIs), formerly called Functional Gastrointestinal Disorders (FGIDs).

QUESTIONNAIRES

Name of Instrument Description of Instrument Non-English Versions Key Citations; Rome IV Book Rome IV : Two volume textbook of all Rome IV content that contains appendices with PEDIATRIC - ROME FOUNDATIONPEDIATRICS ROME NYROME MEDICAL GROUP ROME

NY

Rome IV Pediatric Functional Gastrointestinal Disorders – Disorders of Gut-Brain Interaction (First Edition). The field of pediatric FGIDs has grown over the last two decades, and for this reason we have decided to publish a separate book on pediatric FGIDs, which

ROME IV CRITERIA

Diagnostic criteria. New, or worsening, symptoms of constipation when initiating, changing, or increasing opioid therapy, that must include two or more of the following: Straining during more than ¼ (25%) of defecations. Lumpy or hard stools (Bristol Stool Form GUIDELINES - ROME FOUNDATION The Rome Foundation itself will be preparing official versions of its material in several central languages. When completed, those versions will be the officially sanctioned versions of the Rome Foundation and should be used in all cases. Translation into other languages will have to be conducted in accordance with the enclosed guidelines.

GASTROPSYCH

The Rome GastroPsych group is excited to announce the handbook for Mental Health Professionals in Psychogastroenterology is now available online! Co-written by Dr. Laurie Keefer, PhD, Rome Board member and co-director of the Rome Psychogastro Committee, this handbook is an excellent resource for all mental health professionals working with gastroenterology patients. EFFECTS OF TRAUMA AND ABUSE ON THE BRAIN: BEFORE AND AFTEREFFECTS OF EMOTIONAL TRAUMA ON THE BRAIN My research shows that there is a physiological and structural change in the brain that causes more severe pain in victims of abuse and trauma. But my research also contains proof of a reason to be hopeful: brain scans of patients taken after treatment prove that these changes are reversible. If you or a loved one is suffering, I encourage you GALLBLADDER AND SPHINCTER OF ODDI DISORDERS Gallbladder and Sphincter of Oddi Disorders Peter B. Cotton,1 Grace H. Elta,2 C. Ross Carter,3 Pankaj Jay Pasricha,4 Enrico S. Corazziari5 1Medical University of South Carolina, Charleston, South Carolina; 2University of Michigan, Ann Arbor, Michigan; 3Glasgow Royal Infirmary, Glasgow, Scotland; 4Johns Hopkins School of Medicine, Baltimore, Maryland; and 5Universita La Sapienza, BLOATING AND DISTENSION: WHAT’S THE DIFFERENCE? Bloating and Distension: What’s the Difference? When a person describes the feeling of bloating, they may or may not be aware of an increase in abdominal girth. The former is a symptom and the latter is a visible swelling and feeling of tightness of their skin or clothing along with discomfort. Often, patients will describe this as if a CHILDHOOD FUNCTIONAL GASTROINTESTINAL DISORDERS: CHILD Childhood Functional Gastrointestinal Disorders: Child/ Adolescent Jeffrey S. Hyams,1,* Carlo Di Lorenzo,2,* Miguel Saps,2 Robert J. Shulman,3 Annamaria Staiano,4 and Miranda van Tilburg5 1Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children’sMedicalCenter,Hartford, Connecticut; 2Division of Digestive Diseases, Hepatology, and Nutrition, Nationwide Children’s WELCOME TO THE ROME FOUNDATION Our mission is to improve the lives of people with Disorders of Gut-Brain Interaction. The Rome Foundation is an independent not-for-profit organization dedicated to supporting the creation of scientific data and educational information to assist in diagnosing and treating Disorders of Gut-Brain Interaction (DGBIs), formerly called Functional Gastrointestinal Disorders (FGIDs).

QUESTIONNAIRES

Name of Instrument Description of Instrument Non-English Versions Key Citations; Rome IV Book Rome IV : Two volume textbook of all Rome IV content that contains appendices with PEDIATRIC - ROME FOUNDATIONPEDIATRICS ROME NYROME MEDICAL GROUP ROME

NY

Rome IV Pediatric Functional Gastrointestinal Disorders – Disorders of Gut-Brain Interaction (First Edition). The field of pediatric FGIDs has grown over the last two decades, and for this reason we have decided to publish a separate book on pediatric FGIDs, which

ROME IV CRITERIA

Diagnostic criteria. New, or worsening, symptoms of constipation when initiating, changing, or increasing opioid therapy, that must include two or more of the following: Straining during more than ¼ (25%) of defecations. Lumpy or hard stools (Bristol Stool Form GUIDELINES - ROME FOUNDATION The Rome Foundation itself will be preparing official versions of its material in several central languages. When completed, those versions will be the officially sanctioned versions of the Rome Foundation and should be used in all cases. Translation into other languages will have to be conducted in accordance with the enclosed guidelines.

GASTROPSYCH

The Rome GastroPsych group is excited to announce the handbook for Mental Health Professionals in Psychogastroenterology is now available online! Co-written by Dr. Laurie Keefer, PhD, Rome Board member and co-director of the Rome Psychogastro Committee, this handbook is an excellent resource for all mental health professionals working with gastroenterology patients. EFFECTS OF TRAUMA AND ABUSE ON THE BRAIN: BEFORE AND AFTEREFFECTS OF EMOTIONAL TRAUMA ON THE BRAIN My research shows that there is a physiological and structural change in the brain that causes more severe pain in victims of abuse and trauma. But my research also contains proof of a reason to be hopeful: brain scans of patients taken after treatment prove that these changes are reversible. If you or a loved one is suffering, I encourage you GALLBLADDER AND SPHINCTER OF ODDI DISORDERS Gallbladder and Sphincter of Oddi Disorders Peter B. Cotton,1 Grace H. Elta,2 C. Ross Carter,3 Pankaj Jay Pasricha,4 Enrico S. Corazziari5 1Medical University of South Carolina, Charleston, South Carolina; 2University of Michigan, Ann Arbor, Michigan; 3Glasgow Royal Infirmary, Glasgow, Scotland; 4Johns Hopkins School of Medicine, Baltimore, Maryland; and 5Universita La Sapienza, BLOATING AND DISTENSION: WHAT’S THE DIFFERENCE? Bloating and Distension: What’s the Difference? When a person describes the feeling of bloating, they may or may not be aware of an increase in abdominal girth. The former is a symptom and the latter is a visible swelling and feeling of tightness of their skin or clothing along with discomfort. Often, patients will describe this as if a CHILDHOOD FUNCTIONAL GASTROINTESTINAL DISORDERS: CHILD Childhood Functional Gastrointestinal Disorders: Child/ Adolescent Jeffrey S. Hyams,1,* Carlo Di Lorenzo,2,* Miguel Saps,2 Robert J. Shulman,3 Annamaria Staiano,4 and Miranda van Tilburg5 1Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children’sMedicalCenter,Hartford, Connecticut; 2Division of Digestive Diseases, Hepatology, and Nutrition, Nationwide Children’s ABOUT THE ROME FOUNDATION The Rome Foundation is an independent not for profit 501(c) 3 organization that provides support for activities designed to create scientific data and educational information to assist in the diagnosis and treatment of Disorders of Gut Brain Interactions (DGBIs).Our mission is to improve the lives of people with functional GI disorders. Over the last 20 years, the Rome organization has sought PEDIATRIC - ROME FOUNDATION Rome IV Pediatric Functional Gastrointestinal Disorders – Disorders of Gut-Brain Interaction (First Edition). The field of pediatric FGIDs has grown over the last two decades, and for this reason we have decided to publish a separate book on pediatric FGIDs, which is EFFECTS OF TRAUMA AND ABUSE ON THE BRAIN: BEFORE AND AFTER In other words, the pain is real. It is not all in the patient’s head and it’s not a psychiatric condition. My research shows that there is a physiological and structural change in the brain that causes more severe pain in victims of abuse and trauma. WHAT’S NEW FOR ROME IV The Rome Foundation has sought to maintain a strong knowledge base in the field and that has occurred mainly with revisions every 6-10 years. Rome IV updates include a redefinition of FGIDs and diagnostic criteria, addition of newly recognized disorders, and major changes in criteria for existing disorders (1). BRAIN-GUT PSYCHOTHERAPIES WORKING TEAM This Rome Foundation Working Team will provide an authoritative document on BGPs from internationally recognized experts, including recommendations for what works for whom. We will also highlight some of the promising areas for future research. Working Team Members: Laurie Keefer, PhD-Chair. Mount Sinai (New York City, USA) Douglas

Drossman, MD.

BLOATING AND DISTENSION: WHAT’S THE DIFFERENCE? Bloating and Distension: What’s the Difference? When a person describes the feeling of bloating, they may or may not be aware of an increase in abdominal girth. The former is a symptom and the latter is a visible swelling and feeling of tightness of their skin or clothing along with discomfort. Often, patients will describe this as if a

PEDIATRIC COMMITTEE

Pediatric Committee. The Rome Foundation Pediatric Committee provides the structure to foster and further develop the pediatric GI components of the Rome foundation that will cover aspects of education, research and patient care. Since the initial development of the pediatric Rome criteria in 1999 there has been a major increase in

their

BOWEL DISORDERS

Bowel Disorders Brian E. Lacy,1 Fermín Mearin,2 Lin Chang,3 William D. Chey,4 Anthony J. Lembo,5 Magnus Simren,6 and Robin Spiller7 1Division of Gastroenterology and Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; 2Institute of Functional and Motor Digestive Disorders, Centro Médico Teknon, Barcelona, Spain; 3David Geffen School of Medicine at MENTAL HEALTH PROFESSIONALS IN PSYCHOGASTROENTEROLOGY IN The Rome GastroPsych group is excited to announce that the handbook for Mental Health Professionals in Psychogastroenterology in now available online! Co-written by Dr. Laurie Keefer, PhD, Rome Board member and co-director of the Rome Psychogastro Committee, this handbook is an excellent resource for all mental health professionals

working with

KEN HEATON AWARD

Giada De Palma, PhD Title: “Microbiota and host determinants of behavioural phenotype in maternally separated mice.” Nature Communications 2015; 6; 7735. doi: 10.1038/ncomms8735. PMID: 26218677. This article was cited 35 times. Dr. Giada De Palma is a research

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OUR MISSION IS TO IMPROVE THE LIVES OF PEOPLE WITH DISORDERS OF GUT-BRAIN INTERACTION The Rome Foundation is an independent not-for-profit organization dedicated to supporting the creation of scientific data and educational information to assist in diagnosing and treating Disorders of Gut-Brain Interaction (DGBIs), formerly called Functional Gastrointestinal Disorders (FGIDs). For almost three decades, the Rome Foundation has sought to legitimize and update our knowledge of the DGBIs. We do this by bringing together scientists and clinicians from around the world to classify and critically appraise the science of gastrointestinal function and dysfunction. This helps clinical scientists to make recommendations for diagnosis and treatment that can be applied in research and

clinical practice.

The Rome Foundation is committed to the continuous development, legitimization and preservation of the field of DGBIs through science-based activities. We are inclusive and collaborative, patient-centered, innovative, and open to new ideas. For more information about us, please download our booklet, Meet the

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Latest News & Updates GUT-BRAIN INTERACTIONS IN PATIENTS WITH IBD AND THE ROLE OF HYPNOTHERAPY IN MANAGING SYMPTOMS The benefits of gut directed hypnotherapy have been shown in studies to reduce the severity and frequency of symptoms in patients with Disorders of… MANAGEMENT OF CHRONIC ABDOMINAL DISTENSION AND BLOATING ARTICLE Rome Board Member, Dr. Brian Lacy's article Management of Chronic Abdominal Distension and Bloating is in the Clinical Gastroenterology and Hepatology Journal. Read the full article… GUT FEELINGS: A ROME FOUNDATION/DROSSMANCARE PODCAST SERIES Gut Feelings – A Rome Foundation/DrossmanCare Podcast Series Hosted by Johannah Ruddy, MEd and Douglas Drossman, MD. Join the Rome Foundation and DrossmanCare as we… PODCAST AND ARTICLE WITH NEUROGASTROENTEROLOGY & MOTILITY SOCIETY Douglas A. Drossman, MD is joined by his co-author Jordyn H. Feingold, MD/MSCR Candidate and moderator, Purna Kashyap, MBBS to discuss their latest article "Deconstructing… AMERICAN COLLEGE OF GASTROENTEROLOGY COVER; WINTER 2020 The American College of Gastroenterology featured Dr. Drossman in their Winter 2020 Digital Issue and the article made the cover. You can read the article here.…

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