SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary ISRAEL REPORTS LINK BETWEEN RARE CASES OF HEART Read our COVID-19 research and news. A 16-year-old in Tel Aviv, Israel, receives a dose of the Pfizer-BioNtech COVID-19 vaccine on 23 January. By Gretchen Vogel, Jennifer Couzin-Frankel Jun. 1 COVID-19 VACCINES MAY PROTECT MANY, BUT NOT ALL, PEOPLE COVID-19 vaccines may protect many, but not all, people with suppressed immune systems. By Jennifer Couzin-Frankel Apr. 27, 2021 , 4:25 PM. Science’s COVID-19 reporting is supported by the 125 QUESTIONS: EXPLORATION AND DISCOVERY Read our COVID-19 research and news. 14 May 2021 It is fundamental to the human condition to ask questions, to be inquisitive. It is essential to how we have evolved and thrived as a species. The SENSE CODON REASSIGNMENT ENABLES VIRAL RESISTANCE AND Biological systems read all 64 triplet codons in DNA to encode the synthesis of proteins composed of 20 canonical amino acids. Robertson et al. created cells that do not read several codons and showed that this confers complete resistance to viruses, which normally rely on the host cell's ability to read all the codons in the viral genome to reproduce (see the Perspective by Jewel and DECADES AFTER A TRAGIC FAILURE, GENE THERAPY SUCCESSFULLY Read our COVID-19 research and news. Josh McQuillin, shown in 2019, 1 year after being treated, says gene therapy has transformed his life. By Jocelyn Kaiser May. 18, 2021 , SUSPICIONS GROW THAT NANOPARTICLES IN PFIZER’S COVID-19 Suspicions grow that nanoparticles in Pfizer’s COVID-19 vaccine trigger rare allergic reactions. By Jop de Vrieze Dec. 21, 2020 , 5:10 PM. Science’s COVID-19 reporting is supported by the FACT-CHECKING JUDY MIKOVITS, THE CONTROVERSIAL VIROLOGIST Fact-checking Judy Mikovits, the controversial virologist attacking Anthony Fauci in a viral conspiracy video. By Martin Enserink, Jon Cohen May. 8, 2020 , MYSTERY SOLVED? WHY CATS EAT GRASS Mystery solved? Why cats eat grass. By David Shultz Aug. 8, 2019 , 1:45 PM. Cats do a lot of weird things. One of the biggies is eating grass, often to throw it up just a few minutes later.

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Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.All content is Derek’s own, and he does not in any way speak for his employer. SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary ISRAEL REPORTS LINK BETWEEN RARE CASES OF HEART Read our COVID-19 research and news. A 16-year-old in Tel Aviv, Israel, receives a dose of the Pfizer-BioNtech COVID-19 vaccine on 23 January. By Gretchen Vogel, Jennifer Couzin-Frankel Jun. 1 COVID-19 VACCINES MAY PROTECT MANY, BUT NOT ALL, PEOPLE COVID-19 vaccines may protect many, but not all, people with suppressed immune systems. By Jennifer Couzin-Frankel Apr. 27, 2021 , 4:25 PM. Science’s COVID-19 reporting is supported by the 125 QUESTIONS: EXPLORATION AND DISCOVERY Read our COVID-19 research and news. 14 May 2021 It is fundamental to the human condition to ask questions, to be inquisitive. It is essential to how we have evolved and thrived as a species. The SENSE CODON REASSIGNMENT ENABLES VIRAL RESISTANCE AND Biological systems read all 64 triplet codons in DNA to encode the synthesis of proteins composed of 20 canonical amino acids. Robertson et al. created cells that do not read several codons and showed that this confers complete resistance to viruses, which normally rely on the host cell's ability to read all the codons in the viral genome to reproduce (see the Perspective by Jewel and DECADES AFTER A TRAGIC FAILURE, GENE THERAPY SUCCESSFULLY Read our COVID-19 research and news. Josh McQuillin, shown in 2019, 1 year after being treated, says gene therapy has transformed his life. By Jocelyn Kaiser May. 18, 2021 , SUSPICIONS GROW THAT NANOPARTICLES IN PFIZER’S COVID-19 Suspicions grow that nanoparticles in Pfizer’s COVID-19 vaccine trigger rare allergic reactions. By Jop de Vrieze Dec. 21, 2020 , 5:10 PM. Science’s COVID-19 reporting is supported by the FACT-CHECKING JUDY MIKOVITS, THE CONTROVERSIAL VIROLOGIST Fact-checking Judy Mikovits, the controversial virologist attacking Anthony Fauci in a viral conspiracy video. By Martin Enserink, Jon Cohen May. 8, 2020 , MYSTERY SOLVED? WHY CATS EAT GRASS Mystery solved? Why cats eat grass. By David Shultz Aug. 8, 2019 , 1:45 PM. Cats do a lot of weird things. One of the biggies is eating grass, often to throw it up just a few minutes later.

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Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.All content is Derek’s own, and he does not in any way speak for his employer. ACCESS AND SUBSCRIPTIONS Individual subscriptions are available for News from Science via our metered paywall. Please contact a AAAS MemberCentral Support associate by phone at: 202-326-6417 or toll free in the United INVESTIGATE THE ORIGINS OF COVID-19 On 30 December 2019, the Program for Monitoring Emerging Diseases notified the world about a pneumonia of unknown cause in Wuhan, China (). Since then, scientists have made remarkable progress in understanding the causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), its transmission, pathogenesis, and mitigation by vaccines, therapeutics, JOURNAL METRICS OVERVIEW Journal metrics overview. This page provides journal profiles, turnaround times, citation distributions, and journal metrics for the Science family of journals and is updated on an annual basis THE STORY BEHIND COVID-19 VACCINES Amid the staggering amount of suffering and death during this historic pandemic of COVID-19, a remarkable success story stands out. The development of several highly efficacious vaccines against a previously unknown viral pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in less than 1 year from the identification of the virus is unprecedented in the history of

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SCIENCE ADVANCES

By Corentin Bochaton, Emmanuel Paradis, Salvador Bailon, Sandrine Grouard, Ivan Ineich, Arnaud Lenoble, Olivier Lorvelec, Anne Tresset, Nicole Boivin. Science Advances 19 May 2021 : eabg2111. Open Access. Indigenous human populations in Guadeloupe coexisted with island reptile species extinguished by later European colonialists. Abstract.

SCIENCE CAREERS

Read our COVID-19 research and news. Careers Editorial | Jun. 3, 2021 ROBERT NEUBECKER Careers Editorial | Jun. 2, 2021 Oscar Vazquez-Mena Careers Editorial | May. 27, 2021 Careers Editorial | May PREPARING FOR FLOODS ON THE THIRD POLE The mountains that include the Himalayan and adjacent ranges are the highest on Earth and have an average elevation of >4000 m and an area of ∼595,000 km2. This region is also called the Third Pole or the Asian water tower because it has the largest ice mass outside the polar regions. Increasing temperatures and human interventions have added stress on the region's hydrological sensitivity RESEARCH - SCIENCE.SCIENCEMAG.ORG patterns has been primarily stud-ied at the transcriptional level, but the fate of these transcripts has received little attention. Dufourt et al. used the SunTag labeling method to image ANCIENT DNA REVEALS FATE OF THE MYSTERIOUS CANAANITES Ancient DNA reveals fate of the mysterious Canaanites. By Lizzie Wade Jul. 27, 2017 , 12:00 PM. When the pharaohs ruled Egypt and the ancient Greeks built their first cities, a mysterious people SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary SENSE CODON REASSIGNMENT ENABLES VIRAL RESISTANCE AND Biological systems read all 64 triplet codons in DNA to encode the synthesis of proteins composed of 20 canonical amino acids. Robertson et al. created cells that do not read several codons and showed that this confers complete resistance to viruses, which normally rely on the host cell's ability to read all the codons in the viral genome to reproduce (see the Perspective by Jewel and COVID-19 VACCINES MAY PROTECT MANY, BUT NOT ALL, PEOPLE COVID-19 vaccines may protect many, but not all, people with suppressed immune systems. By Jennifer Couzin-Frankel Apr. 27, 2021 , 4:25 PM. Science’s COVID-19 reporting is supported by the ANTIBODY FUCOSYLATION PREDICTS DISEASE SEVERITY IN Science 04 Jun 2021: Vol. 372, Issue 6546, pp. 1102-1105 DOI: 10.1126/science.abc7303 INVESTIGATE THE ORIGINS OF COVID-19 694 14 MAY 2021 • VOL 372 ISSUE 6543 sciencemag.org SCIENCE PHOTO: MARIO SUAREZ PORRAS/MINDEN PICTURES Investigate the origins of COVID-19 On 30 December 2019, the Program for Monitoring Emerging

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BIDEN SEEKS BIG INCREASES FOR SCIENCE BUDGETS Biden seeks big increases for science budgets. By Science News Staff May. 28, 2021 , 6:55 PM. President Joe Biden today asked Congress to

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CO2 ELECTROLYSIS TO MULTICARBON PRODUCTS IN STRONG ACID Electrochemical reduction of carbon dioxide (CO2) is a promising means of converting this greenhouse gas into valuable fuels and chemicals. However, two competing reactions restrict the efficiency of this process. In base, much of the CO2 is trapped as carbonate before reduction; in acid, protons outpace CO2 at catching electrons from the cathode. Huang et al. report that a high dose of SENATE PANEL BACKS FUNDING BAN ON U.S. RESEARCHERS IN Senate panel backs funding ban on U.S. researchers in Chinese talent programs. By Jeffrey Mervis May. 13, 2021 , 10:25 AM. The U.S. Senate’s commerce committee has voted to ban any U.S U.K. SET TO LOOSEN RULES FOR GENE-EDITED CROPS AND ANIMALS Read our COVID-19 research and news. U.K. rules on gene editing are expected to be less strict than those for transgenic crops like this iron-rich wheat the John Innes Center is testing. By Erik

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Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.All content is Derek’s own, and he does not in any way speak for his employer. SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary SENSE CODON REASSIGNMENT ENABLES VIRAL RESISTANCE AND Biological systems read all 64 triplet codons in DNA to encode the synthesis of proteins composed of 20 canonical amino acids. Robertson et al. created cells that do not read several codons and showed that this confers complete resistance to viruses, which normally rely on the host cell's ability to read all the codons in the viral genome to reproduce (see the Perspective by Jewel and COVID-19 VACCINES MAY PROTECT MANY, BUT NOT ALL, PEOPLE COVID-19 vaccines may protect many, but not all, people with suppressed immune systems. By Jennifer Couzin-Frankel Apr. 27, 2021 , 4:25 PM. Science’s COVID-19 reporting is supported by the ANTIBODY FUCOSYLATION PREDICTS DISEASE SEVERITY IN Science 04 Jun 2021: Vol. 372, Issue 6546, pp. 1102-1105 DOI: 10.1126/science.abc7303 INVESTIGATE THE ORIGINS OF COVID-19 694 14 MAY 2021 • VOL 372 ISSUE 6543 sciencemag.org SCIENCE PHOTO: MARIO SUAREZ PORRAS/MINDEN PICTURES Investigate the origins of COVID-19 On 30 December 2019, the Program for Monitoring Emerging

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BIDEN SEEKS BIG INCREASES FOR SCIENCE BUDGETS Biden seeks big increases for science budgets. By Science News Staff May. 28, 2021 , 6:55 PM. President Joe Biden today asked Congress to

give

CO2 ELECTROLYSIS TO MULTICARBON PRODUCTS IN STRONG ACID Electrochemical reduction of carbon dioxide (CO2) is a promising means of converting this greenhouse gas into valuable fuels and chemicals. However, two competing reactions restrict the efficiency of this process. In base, much of the CO2 is trapped as carbonate before reduction; in acid, protons outpace CO2 at catching electrons from the cathode. Huang et al. report that a high dose of SENATE PANEL BACKS FUNDING BAN ON U.S. RESEARCHERS IN Senate panel backs funding ban on U.S. researchers in Chinese talent programs. By Jeffrey Mervis May. 13, 2021 , 10:25 AM. The U.S. Senate’s commerce committee has voted to ban any U.S U.K. SET TO LOOSEN RULES FOR GENE-EDITED CROPS AND ANIMALS Read our COVID-19 research and news. U.K. rules on gene editing are expected to be less strict than those for transgenic crops like this iron-rich wheat the John Innes Center is testing. By Erik

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Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine.All content is Derek’s own, and he does not in any way speak for his employer. LAB-GROWN MINIHEARTS BEAT LIKE THE REAL THING Lab-grown minihearts beat like the real thing. By Sofia Moutinho May. 20, 2021 , 11:05 AM. They are no bigger than sesame seeds, and they pulse with a hypnotic rhythm. These are human

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1 day ago · www.sciencemag.org THE GROWING CHALLENGE OF VEGETATION CHANGE A substantial portion of the planet has been on fire. Climate change has been implicated in sweeping wildfires in the western United States, Australia, the boreal forest stretching around the globe, Amazonia, and elsewhere (). Other forests have experienced extensive tree loss, again largely because of hotter and drier climate extremes (, ). Forest disturbance driven by

SCIENCE ADVANCES

By Corentin Bochaton, Emmanuel Paradis, Salvador Bailon, Sandrine Grouard, Ivan Ineich, Arnaud Lenoble, Olivier Lorvelec, Anne Tresset, Nicole Boivin. Science Advances 19 May 2021 : eabg2111. Open Access. Indigenous human populations in Guadeloupe coexisted with island reptile species extinguished by later European colonialists. Abstract.

SCIENCE IMMUNOLOGY

By Yu Sawada, Teruaki Nakatsuji, Tatsuya Dokoshi, Nikhil Nitin Kulkarni, Marc C. Liggins, George Sen, Richard L. Gallo. Science Immunology 21 May 2021. Full Access Restricted Access. Inhibition of HDAC8 and HDAC9 impairs keratinocyte tolerance of TLR ligand stimulation, leading to cutaneous inflammation. Editor's Summary. CHINA'S DHOLE POPULATION AT RISK OF EXTINCTION The dhole ( Cuon alpinus ), a mountain canid species that once lived throughout north, south, and southeast Asia (), is endangered worldwide (, ). Now found primarily in the forests, shrub belts, and grasslands of southeastern China (), the dhole population includes only 949 to 2215 individuals with reproductive capacity (). Although there have been PREPARING FOR FLOODS ON THE THIRD POLE The mountains that include the Himalayan and adjacent ranges are the highest on Earth and have an average elevation of >4000 m and an area of ∼595,000 km2. This region is also called the Third Pole or the Asian water tower because it has the largest ice mass outside the polar regions. Increasing temperatures and human interventions have added stress on the region's hydrological sensitivity STORING WIND AS GRAVITY, AND WELL-DIGGING DONKEYS Storing wind as gravity, and well-digging donkeys. Contributing Correspondent Cathleen O’Grady joins host Sarah Crespi to talk about a company that stores renewable energy by hoisting large RESEARCH - SCIENCE.SCIENCEMAG.ORG distant galaxy. The GRB itself lasts only a few seconds but is followed by an afterglow that can persist for hours or days. The H.E.S.S. Collaboration WANT TO REPEL MOSQUITOES? DON’T USE CITRONELLA CANDLES Don’t use citronella candles. By Gwen Pearson Feb. 16, 2017 , 9:30 AM. Citronella candles are great for setting a mood, but they’re not so great for the very thing they’re advertised to do SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary ISRAEL REPORTS LINK BETWEEN RARE CASES OF HEART Read our COVID-19 research and news. A 16-year-old in Tel Aviv, Israel, receives a dose of the Pfizer-BioNtech COVID-19 vaccine on 23 January. By Gretchen Vogel, Jennifer Couzin-Frankel Jun. 1 COVID-19 VACCINES MAY PROTECT MANY, BUT NOT ALL, PEOPLE COVID-19 vaccines may protect many, but not all, people with suppressed immune systems. By Jennifer Couzin-Frankel Apr. 27, 2021 , 4:25 PM. Science’s COVID-19 reporting is supported by the SCIENTISTS EVOLVE A FUNGUS TO BATTLE DEADLY HONEY BEE Scientists evolve a fungus to battle deadly honey bee parasite. By Erik Stokstad Jun. 4, 2021 , 4:10 PM. The biggest scourge to bees is tiny—a mite the size of a pinhead that feeds on them and ACCESS AND SUBSCRIPTIONS Individual subscriptions are available for News from Science via our metered paywall. Please contact a AAAS MemberCentral Support associate by phone at: 202-326-6417 or toll free in the United

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By Corentin Bochaton, Emmanuel Paradis, Salvador Bailon, Sandrine Grouard, Ivan Ineich, Arnaud Lenoble, Olivier Lorvelec, Anne Tresset, Nicole Boivin. Science Advances 19 May 2021 : eabg2111. Open Access. Indigenous human populations in Guadeloupe coexisted with island reptile species extinguished by later European colonialists. Abstract. SENSE CODON REASSIGNMENT ENABLES VIRAL RESISTANCE AND Biological systems read all 64 triplet codons in DNA to encode the synthesis of proteins composed of 20 canonical amino acids. Robertson et al. created cells that do not read several codons and showed that this confers complete resistance to viruses, which normally rely on the host cell's ability to read all the codons in the viral genome to reproduce (see the Perspective by Jewel and U.K. SET TO LOOSEN RULES FOR GENE-EDITED CROPS AND ANIMALS Read our COVID-19 research and news. U.K. rules on gene editing are expected to be less strict than those for transgenic crops like this iron-rich wheat the John Innes Center is testing. By Erik CHINA'S DHOLE POPULATION AT RISK OF EXTINCTION The dhole ( Cuon alpinus ), a mountain canid species that once lived throughout north, south, and southeast Asia (), is endangered worldwide (, ). Now found primarily in the forests, shrub belts, and grasslands of southeastern China (), the dhole population includes only 949 to 2215 individuals with reproductive capacity (). Although there have been PREPARING FOR FLOODS ON THE THIRD POLE The mountains that include the Himalayan and adjacent ranges are the highest on Earth and have an average elevation of >4000 m and an area of ∼595,000 km2. This region is also called the Third Pole or the Asian water tower because it has the largest ice mass outside the polar regions. Increasing temperatures and human interventions have added stress on the region's hydrological sensitivity SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary ISRAEL REPORTS LINK BETWEEN RARE CASES OF HEART Read our COVID-19 research and news. A 16-year-old in Tel Aviv, Israel, receives a dose of the Pfizer-BioNtech COVID-19 vaccine on 23 January. By Gretchen Vogel, Jennifer Couzin-Frankel Jun. 1 COVID-19 VACCINES MAY PROTECT MANY, BUT NOT ALL, PEOPLE COVID-19 vaccines may protect many, but not all, people with suppressed immune systems. By Jennifer Couzin-Frankel Apr. 27, 2021 , 4:25 PM. Science’s COVID-19 reporting is supported by the SCIENTISTS EVOLVE A FUNGUS TO BATTLE DEADLY HONEY BEE Scientists evolve a fungus to battle deadly honey bee parasite. By Erik Stokstad Jun. 4, 2021 , 4:10 PM. The biggest scourge to bees is tiny—a mite the size of a pinhead that feeds on them and ACCESS AND SUBSCRIPTIONS Individual subscriptions are available for News from Science via our metered paywall. Please contact a AAAS MemberCentral Support associate by phone at: 202-326-6417 or toll free in the United

SCIENCE ADVANCES

By Corentin Bochaton, Emmanuel Paradis, Salvador Bailon, Sandrine Grouard, Ivan Ineich, Arnaud Lenoble, Olivier Lorvelec, Anne Tresset, Nicole Boivin. Science Advances 19 May 2021 : eabg2111. Open Access. Indigenous human populations in Guadeloupe coexisted with island reptile species extinguished by later European colonialists. Abstract. SENSE CODON REASSIGNMENT ENABLES VIRAL RESISTANCE AND Biological systems read all 64 triplet codons in DNA to encode the synthesis of proteins composed of 20 canonical amino acids. Robertson et al. created cells that do not read several codons and showed that this confers complete resistance to viruses, which normally rely on the host cell's ability to read all the codons in the viral genome to reproduce (see the Perspective by Jewel and U.K. SET TO LOOSEN RULES FOR GENE-EDITED CROPS AND ANIMALS Read our COVID-19 research and news. U.K. rules on gene editing are expected to be less strict than those for transgenic crops like this iron-rich wheat the John Innes Center is testing. By Erik CHINA'S DHOLE POPULATION AT RISK OF EXTINCTION The dhole ( Cuon alpinus ), a mountain canid species that once lived throughout north, south, and southeast Asia (), is endangered worldwide (, ). Now found primarily in the forests, shrub belts, and grasslands of southeastern China (), the dhole population includes only 949 to 2215 individuals with reproductive capacity (). Although there have been PREPARING FOR FLOODS ON THE THIRD POLE The mountains that include the Himalayan and adjacent ranges are the highest on Earth and have an average elevation of >4000 m and an area of ∼595,000 km2. This region is also called the Third Pole or the Asian water tower because it has the largest ice mass outside the polar regions. Increasing temperatures and human interventions have added stress on the region's hydrological sensitivity JOURNALS | SCIENCE | AAAS Research. The Open Access journal Research, published in association with CAST, publishes innovative, wide-ranging research in life sciences, physical sciences, engineering and THE RISE AND FALL OF THE WORLD’S LARGEST LAKE The rise and fall of the world’s largest lake. By Sid Perkins Jun. 4, 2021 , 5:15 PM. When continental plates smashed together about 12 million years ago, they didn’t just raise new mountains BIDEN SEEKS BIG INCREASES FOR SCIENCE BUDGETS Biden seeks big increases for science budgets. By Science News Staff May. 28, 2021 , 6:55 PM. President Joe Biden today asked Congress to

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ACCESS AND SUBSCRIPTIONS Individual subscriptions are available for News from Science via our metered paywall. Please contact a AAAS MemberCentral Support associate by phone at: 202-326-6417 or toll free in the United ARTIFICIAL INTELLIGENCE COULD HELP BIOLOGISTS CLASSIFY THE Artificial intelligence could help biologists classify the world’s tiny creatures. By Elizabeth Pennisi Jun. 4, 2021 , 5:00 PM. With biodiversity in decline around the world, researchers are

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1 day ago · www.sciencemag.org FURTHER EVIDENCE SUPPORTS CONTROVERSIAL CLAIM THAT SARS Further evidence supports controversial claim that SARS-CoV-2 genes can integrate with human DNA. By Jon Cohen May. 6, 2021 , 2:45 PM. Science’s COVID-19 WEBINARS | SCIENCE | AAAS Get webinar alerts. For more information on upcoming webinars, recorded sessions and more, sign up for webinar alerts. Sign up here SENATE PANEL BACKS FUNDING BAN ON U.S. RESEARCHERS IN Senate panel backs funding ban on U.S. researchers in Chinese talent programs. By Jeffrey Mervis May. 13, 2021 , 10:25 AM. The U.S. Senate’s commerce committee has voted to ban any U.S SUSPICIONS GROW THAT NANOPARTICLES IN PFIZER’S COVID-19 Suspicions grow that nanoparticles in Pfizer’s COVID-19 vaccine trigger rare allergic reactions. By Jop de Vrieze Dec. 21, 2020 , 5:10 PM. Science’s COVID-19 reporting is supported by the SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary ANTIBODY FUCOSYLATION PREDICTS DISEASE SEVERITY IN Science 04 Jun 2021: Vol. 372, Issue 6546, pp. 1102-1105 DOI: 10.1126/science.abc7303 INVESTIGATE THE ORIGINS OF COVID-19 694 14 MAY 2021 • VOL 372 ISSUE 6543 sciencemag.org SCIENCE PHOTO: MARIO SUAREZ PORRAS/MINDEN PICTURES Investigate the origins of COVID-19 On 30 December 2019, the Program for Monitoring Emerging

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SENSE CODON REASSIGNMENT ENABLES VIRAL RESISTANCE AND Biological systems read all 64 triplet codons in DNA to encode the synthesis of proteins composed of 20 canonical amino acids. Robertson et al. created cells that do not read several codons and showed that this confers complete resistance to viruses, which normally rely on the host cell's ability to read all the codons in the viral genome to reproduce (see the Perspective by Jewel and SUPPLEMENTARY MATERIALS Ondřej Mottl, Suzette G. A. Flantua, Kuber P. Bhatta, Vivian A. Felde, Thomas Giesecke, Simon Goring, Eric C. Grimm, Simon Haberle, Henry Hooghiemstra, Sarah Ivory U.K. SET TO LOOSEN RULES FOR GENE-EDITED CROPS AND ANIMALS Read our COVID-19 research and news. U.K. rules on gene editing are expected to be less strict than those for transgenic crops like this iron-rich wheat the John Innes Center is testing. By Erik CHINA'S DHOLE POPULATION AT RISK OF EXTINCTION The dhole ( Cuon alpinus ), a mountain canid species that once lived throughout north, south, and southeast Asia (), is endangered worldwide (, ). Now found primarily in the forests, shrub belts, and grasslands of southeastern China (), the dhole population includes only 949 to 2215 individuals with reproductive capacity (). Although there have been PREPARING FOR FLOODS ON THE THIRD POLE The mountains that include the Himalayan and adjacent ranges are the highest on Earth and have an average elevation of >4000 m and an area of ∼595,000 km2. This region is also called the Third Pole or the Asian water tower because it has the largest ice mass outside the polar regions. Increasing temperatures and human interventions have added stress on the region's hydrological sensitivity

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For many years now, the topic of “senescent cells” has been the subject of plenty of research work. Back in the 1960s the “Hayflick limit” was noticed in cell culture: there was an apparent limit to the number of cell divisions that could take place before the cells just sort of stalled out. CO-DESIGNING HARDWARE AND CONTROL FOR ROBOT HANDS Co-designing hardware and control for robot hands. View ORCID Profile. Tianjian Chen †, Zhanpeng He † and. View ORCID Profile. Matei Ciocarlie *. Department of Mechanical Engineering, School of Engineering and Applied Science, Columbia University. 228 Mudd Building, 500 W 120th St., New York, NY 10027, USA. ↵ * Corresponding author. SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary ANTIBODY FUCOSYLATION PREDICTS DISEASE SEVERITY IN Science 04 Jun 2021: Vol. 372, Issue 6546, pp. 1102-1105 DOI: 10.1126/science.abc7303 INVESTIGATE THE ORIGINS OF COVID-19 694 14 MAY 2021 • VOL 372 ISSUE 6543 sciencemag.org SCIENCE PHOTO: MARIO SUAREZ PORRAS/MINDEN PICTURES Investigate the origins of COVID-19 On 30 December 2019, the Program for Monitoring Emerging

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SENSE CODON REASSIGNMENT ENABLES VIRAL RESISTANCE AND Biological systems read all 64 triplet codons in DNA to encode the synthesis of proteins composed of 20 canonical amino acids. Robertson et al. created cells that do not read several codons and showed that this confers complete resistance to viruses, which normally rely on the host cell's ability to read all the codons in the viral genome to reproduce (see the Perspective by Jewel and SUPPLEMENTARY MATERIALS Ondřej Mottl, Suzette G. A. Flantua, Kuber P. Bhatta, Vivian A. Felde, Thomas Giesecke, Simon Goring, Eric C. Grimm, Simon Haberle, Henry Hooghiemstra, Sarah Ivory U.K. SET TO LOOSEN RULES FOR GENE-EDITED CROPS AND ANIMALS Read our COVID-19 research and news. U.K. rules on gene editing are expected to be less strict than those for transgenic crops like this iron-rich wheat the John Innes Center is testing. By Erik CHINA'S DHOLE POPULATION AT RISK OF EXTINCTION The dhole ( Cuon alpinus ), a mountain canid species that once lived throughout north, south, and southeast Asia (), is endangered worldwide (, ). Now found primarily in the forests, shrub belts, and grasslands of southeastern China (), the dhole population includes only 949 to 2215 individuals with reproductive capacity (). Although there have been PREPARING FOR FLOODS ON THE THIRD POLE The mountains that include the Himalayan and adjacent ranges are the highest on Earth and have an average elevation of >4000 m and an area of ∼595,000 km2. This region is also called the Third Pole or the Asian water tower because it has the largest ice mass outside the polar regions. Increasing temperatures and human interventions have added stress on the region's hydrological sensitivity

IN THE PIPELINE

For many years now, the topic of “senescent cells” has been the subject of plenty of research work. Back in the 1960s the “Hayflick limit” was noticed in cell culture: there was an apparent limit to the number of cell divisions that could take place before the cells just sort of stalled out. CO-DESIGNING HARDWARE AND CONTROL FOR ROBOT HANDS Co-designing hardware and control for robot hands. View ORCID Profile. Tianjian Chen †, Zhanpeng He † and. View ORCID Profile. Matei Ciocarlie *. Department of Mechanical Engineering, School of Engineering and Applied Science, Columbia University. 228 Mudd Building, 500 W 120th St., New York, NY 10027, USA. ↵ * Corresponding author. ACCESS AND SUBSCRIPTIONS Individual subscriptions are available for News from Science via our metered paywall. Please contact a AAAS MemberCentral Support associate by phone at: 202-326-6417 or toll free in the United

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8 hours ago · Computers/Mathematics The internet goes quantum; Scientific Community NAS ousts member for first time, for sexual harassment; Latin American News Mexican funding agency forces out THE GROWING CHALLENGE OF VEGETATION CHANGE A substantial portion of the planet has been on fire. Climate change has been implicated in sweeping wildfires in the western United States, Australia, the boreal forest stretching around the globe, Amazonia, and elsewhere (). Other forests have experienced extensive tree loss, again largely because of hotter and drier climate extremes (, ). Forest disturbance driven by CHERNOBYL’S RUINS GROW RESTLESS, AND ENTANGLING Chernobyl’s ruins grow restless, and entangling macroscopic objects. Rich Stone, former international news editor at Science and current senior science editor at the Howard Hughes Medical

SCIENCE ROBOTICS

Complex manipulation with a simple robotic hand through contact breaking and caging. By Walter G. Bircher, Andrew S. Morgan, Aaron M. Dollar. Science Robotics 12 May 2021. Full Access Restricted Access. A simple robotic hand leverages sliding, rolling, and contact breaking of objects and caging for highly dexterous manipulation.

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By Quentin Verron, Elin Forslund, Ludwig Brandt, Mattias Leino, Thomas W. Frisk, Per E. Olofsson, Björn Önfelt. Science Signaling 25 May 2021. Full Access Restricted Access. The spatial distribution of activating ligands dictates NK cell synapse formation, stability, and function. Editor's Summary. Abstract. STORING WIND AS GRAVITY, AND WELL-DIGGING DONKEYS Storing wind as gravity, and well-digging donkeys. Contributing Correspondent Cathleen O’Grady joins host Sarah Crespi to talk about a company that stores renewable energy by hoisting large RESEARCH - SCIENCE.SCIENCEMAG.ORG patterns has been primarily stud-ied at the transcriptional level, but the fate of these transcripts has received little attention. Dufourt et al. used the SunTag labeling method to image SALMON AQUACULTURE THREATENS PATAGONIA In March, a massive die-off of farmed salmon sent more than 2.2 million kilos of rotting fish biomass into the fjords and channels of the Pacific Patagonian wilderness (), critical areas for biodiversity conservation. The mass mortality event is part of a pattern in which industrial salmon farming increases eutrophication and boosts harmful micro-algae blooms (), which enter ILLUMINATING THE FIRST BACTERIA The ability to sequence genes and, more recently, whole genomes has transformed our understanding of the tree of life by elucidating the tremendous diversity of microorganisms and by placing plants, animals, and fungi as branches nested among microbial lineages (–). The resulting evolutionary tree divides life into three domains: the exclusively microbial Bacteria and SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary SUPPLEMENTARY MATERIALS Ondřej Mottl, Suzette G. A. Flantua, Kuber P. Bhatta, Vivian A. Felde, Thomas Giesecke, Simon Goring, Eric C. Grimm, Simon Haberle, Henry Hooghiemstra, Sarah Ivory INVESTIGATE THE ORIGINS OF COVID-19 694 14 MAY 2021 • VOL 372 ISSUE 6543 sciencemag.org SCIENCE PHOTO: MARIO SUAREZ PORRAS/MINDEN PICTURES Investigate the origins of COVID-19 On 30 December 2019, the Program for Monitoring Emerging

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U.K. SET TO LOOSEN RULES FOR GENE-EDITED CROPS AND ANIMALS U.K. set to loosen rules for gene-edited crops and animals. By Erik Stokstad May. 26, 2021 , 2:30 PM. When Boris Johnson became prime minister of the United Kingdom in 2019, he pledged to PUTTING A BRAKE ON HUNGER G protein–coupled receptors (GPCRs) interact with heterotrimeric guanine nucleotide-binding (G) proteins to modulate many physiological processes. Their structural properties make them highly druggable targets; 30% of currently prescribed medications target GPCRs. The melanocortin-4 receptor (MC4R) is a brain-expressed GPCR that plays a critical role in the regulation of body weight PREPARING FOR FLOODS ON THE THIRD POLE The mountains that include the Himalayan and adjacent ranges are the highest on Earth and have an average elevation of >4000 m and an area of ∼595,000 km2. This region is also called the Third Pole or the Asian water tower because it has the largest ice mass outside the polar regions. Increasing temperatures and human interventions have added stress on the region's hydrological sensitivity CHINA'S DHOLE POPULATION AT RISK OF EXTINCTION The dhole ( Cuon alpinus ), a mountain canid species that once lived throughout north, south, and southeast Asia (), is endangered worldwide (, ). Now found primarily in the forests, shrub belts, and grasslands of southeastern China (), the dhole population includes only 949 to 2215 individuals with reproductive capacity (). Although there have been SUSPICIONS GROW THAT NANOPARTICLES IN PFIZER’S COVID-19 Suspicions grow that nanoparticles in Pfizer’s COVID-19 vaccine trigger rare allergic reactions. By Jop de Vrieze Dec. 21, 2020 , 5:10 PM. Science’s COVID-19 reporting is supported by the MYSTERY SOLVED? WHY CATS EAT GRASS Mystery solved? Why cats eat grass. By David Shultz Aug. 8, 2019 , 1:45 PM. Cats do a lot of weird things. One of the biggies is eating grass, often to throw it up just a few minutes later.

IN THE PIPELINE

For many years now, the topic of “senescent cells” has been the subject of plenty of research work. Back in the 1960s the “Hayflick limit” was noticed in cell culture: there was an apparent limit to the number of cell divisions that could take place before the cells just sort of stalled out. SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary SUPPLEMENTARY MATERIALS Ondřej Mottl, Suzette G. A. Flantua, Kuber P. Bhatta, Vivian A. Felde, Thomas Giesecke, Simon Goring, Eric C. Grimm, Simon Haberle, Henry Hooghiemstra, Sarah Ivory INVESTIGATE THE ORIGINS OF COVID-19 694 14 MAY 2021 • VOL 372 ISSUE 6543 sciencemag.org SCIENCE PHOTO: MARIO SUAREZ PORRAS/MINDEN PICTURES Investigate the origins of COVID-19 On 30 December 2019, the Program for Monitoring Emerging

Diseases notified

U.K. SET TO LOOSEN RULES FOR GENE-EDITED CROPS AND ANIMALS U.K. set to loosen rules for gene-edited crops and animals. By Erik Stokstad May. 26, 2021 , 2:30 PM. When Boris Johnson became prime minister of the United Kingdom in 2019, he pledged to PUTTING A BRAKE ON HUNGER G protein–coupled receptors (GPCRs) interact with heterotrimeric guanine nucleotide-binding (G) proteins to modulate many physiological processes. Their structural properties make them highly druggable targets; 30% of currently prescribed medications target GPCRs. The melanocortin-4 receptor (MC4R) is a brain-expressed GPCR that plays a critical role in the regulation of body weight PREPARING FOR FLOODS ON THE THIRD POLE The mountains that include the Himalayan and adjacent ranges are the highest on Earth and have an average elevation of >4000 m and an area of ∼595,000 km2. This region is also called the Third Pole or the Asian water tower because it has the largest ice mass outside the polar regions. Increasing temperatures and human interventions have added stress on the region's hydrological sensitivity CHINA'S DHOLE POPULATION AT RISK OF EXTINCTION The dhole ( Cuon alpinus ), a mountain canid species that once lived throughout north, south, and southeast Asia (), is endangered worldwide (, ). Now found primarily in the forests, shrub belts, and grasslands of southeastern China (), the dhole population includes only 949 to 2215 individuals with reproductive capacity (). Although there have been SUSPICIONS GROW THAT NANOPARTICLES IN PFIZER’S COVID-19 Suspicions grow that nanoparticles in Pfizer’s COVID-19 vaccine trigger rare allergic reactions. By Jop de Vrieze Dec. 21, 2020 , 5:10 PM. Science’s COVID-19 reporting is supported by the MYSTERY SOLVED? WHY CATS EAT GRASS Mystery solved? Why cats eat grass. By David Shultz Aug. 8, 2019 , 1:45 PM. Cats do a lot of weird things. One of the biggies is eating grass, often to throw it up just a few minutes later.

IN THE PIPELINE

For many years now, the topic of “senescent cells” has been the subject of plenty of research work. Back in the 1960s the “Hayflick limit” was noticed in cell culture: there was an apparent limit to the number of cell divisions that could take place before the cells just sort of stalled out. BACK TO SCHOOL—SAFELY Coronavirus Severe COVID-19 in children is rare, but many schools remain closed because the transmission risk that school contact poses to adults and the wider community is unknown. Observing the heterogeneity of approaches taken among U.S. school districts, Lessler et al. investigated how different strategies influence COVID-19 transmission rates in the wider community using COVID THE GROWING CHALLENGE OF VEGETATION CHANGE A substantial portion of the planet has been on fire. Climate change has been implicated in sweeping wildfires in the western United States, Australia, the boreal forest stretching around the globe, Amazonia, and elsewhere (). Other forests have experienced extensive tree loss, again largely because of hotter and drier climate extremes (, ). Forest disturbance driven by CARBOHYDRATES, INSULIN, AND OBESITY The primary cause of common human obesity remains uncertain. There are several plausible explanations, including the popular “carbohydrate-insulin” model (CIM), which suggests that body-fat gain results from consumption of carbohydrates that stimulate postprandial insulin, which promotes energy storage and further intake in a vicious cycle. The theoretical basis of the CIM has CHERNOBYL’S RUINS GROW RESTLESS, AND ENTANGLING Chernobyl’s ruins grow restless, and entangling macroscopic objects. Rich Stone, former international news editor at Science and current senior science editor at the Howard Hughes Medical STORING WIND AS GRAVITY, AND WELL-DIGGING DONKEYS Storing wind as gravity, and well-digging donkeys. Contributing Correspondent Cathleen O’Grady joins host Sarah Crespi to talk about a company that stores renewable energy by hoisting large FROM LACTATE TO ANTIDEPRESSANT 14 hours ago · Science Signaling 08 Jun 2021: Vol. 14, Issue 686, eabj8007 DOI: 10.1126/scisignal.abj8007

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14 hours ago · Read our COVID-19 research and news. Naoyuki Kondo Twitter Department of Molecule Genetics, Institute of Biomedical Science, Kansai Medical

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SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary ACCESS AND SUBSCRIPTIONS Individual subscriptions are available for News from Science via our metered paywall. Please contact a AAAS MemberCentral Support associate by phone at: 202-326-6417 or toll free in the United U.K. SET TO LOOSEN RULES FOR GENE-EDITED CROPS AND ANIMALS Read our COVID-19 research and news. U.K. rules on gene editing are expected to be less strict than those for transgenic crops like this iron-rich wheat the John Innes Center is testing. By Erik

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By Corentin Bochaton, Emmanuel Paradis, Salvador Bailon, Sandrine Grouard, Ivan Ineich, Arnaud Lenoble, Olivier Lorvelec, Anne Tresset, Nicole Boivin. Science Advances 19 May 2021 : eabg2111. Open Access. Indigenous human populations in Guadeloupe coexisted with island reptile species extinguished by later European colonialists. Abstract. INVESTIGATE THE ORIGINS OF COVID-19 694 14 MAY 2021 • VOL 372 ISSUE 6543 sciencemag.org SCIENCE PHOTO: MARIO SUAREZ PORRAS/MINDEN PICTURES Investigate the origins of COVID-19 On 30 December 2019, the Program for Monitoring Emerging

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PREPARING FOR FLOODS ON THE THIRD POLE The mountains that include the Himalayan and adjacent ranges are the highest on Earth and have an average elevation of >4000 m and an area of ∼595,000 km2. This region is also called the Third Pole or the Asian water tower because it has the largest ice mass outside the polar regions. Increasing temperatures and human interventions have added stress on the region's hydrological sensitivity CHINA'S DHOLE POPULATION AT RISK OF EXTINCTION The dhole ( Cuon alpinus ), a mountain canid species that once lived throughout north, south, and southeast Asia (), is endangered worldwide (, ). Now found primarily in the forests, shrub belts, and grasslands of southeastern China (), the dhole population includes only 949 to 2215 individuals with reproductive capacity (). Although there have been MYSTERY SOLVED? WHY CATS EAT GRASS Mystery solved? Why cats eat grass. By David Shultz Aug. 8, 2019 , 1:45 PM. Cats do a lot of weird things. One of the biggies is eating grass, often to throw it up just a few minutes later. ANCIENT DNA REVEALS FATE OF THE MYSTERIOUS CANAANITES Ancient DNA reveals fate of the mysterious Canaanites. By Lizzie Wade Jul. 27, 2017 , 12:00 PM. When the pharaohs ruled Egypt and the ancient Greeks built their first cities, a mysterious people

IN THE PIPELINE

For many years now, the topic of “senescent cells” has been the subject of plenty of research work. Back in the 1960s the “Hayflick limit” was noticed in cell culture: there was an apparent limit to the number of cell divisions that could take place before the cells just sort of stalled out. SCIENCE | AAASSCIENCEJOURNALSCONTENTSCORONAVIRUSTOPICSSUBMIT How To Get Published. The strength of Science and its online journal sites rests with the strengths of its community of authors, who provide cutting-edge research, incisive scientific commentary ACCESS AND SUBSCRIPTIONS Individual subscriptions are available for News from Science via our metered paywall. Please contact a AAAS MemberCentral Support associate by phone at: 202-326-6417 or toll free in the United U.K. SET TO LOOSEN RULES FOR GENE-EDITED CROPS AND ANIMALS Read our COVID-19 research and news. U.K. rules on gene editing are expected to be less strict than those for transgenic crops like this iron-rich wheat the John Innes Center is testing. By Erik INVESTIGATE THE ORIGINS OF COVID-19 694 14 MAY 2021 • VOL 372 ISSUE 6543 sciencemag.org SCIENCE PHOTO: MARIO SUAREZ PORRAS/MINDEN PICTURES Investigate the origins of COVID-19 On 30 December 2019, the Program for Monitoring Emerging

Diseases notified

SCIENCE ADVANCES

By Corentin Bochaton, Emmanuel Paradis, Salvador Bailon, Sandrine Grouard, Ivan Ineich, Arnaud Lenoble, Olivier Lorvelec, Anne Tresset, Nicole Boivin. Science Advances 19 May 2021 : eabg2111. Open Access. Indigenous human populations in Guadeloupe coexisted with island reptile species extinguished by later European colonialists. Abstract. PREPARING FOR FLOODS ON THE THIRD POLE The mountains that include the Himalayan and adjacent ranges are the highest on Earth and have an average elevation of >4000 m and an area of ∼595,000 km2. This region is also called the Third Pole or the Asian water tower because it has the largest ice mass outside the polar regions. Increasing temperatures and human interventions have added stress on the region's hydrological sensitivity CHINA'S DHOLE POPULATION AT RISK OF EXTINCTION The dhole ( Cuon alpinus ), a mountain canid species that once lived throughout north, south, and southeast Asia (), is endangered worldwide (, ). Now found primarily in the forests, shrub belts, and grasslands of southeastern China (), the dhole population includes only 949 to 2215 individuals with reproductive capacity (). Although there have been MYSTERY SOLVED? WHY CATS EAT GRASS Mystery solved? Why cats eat grass. By David Shultz Aug. 8, 2019 , 1:45 PM. Cats do a lot of weird things. One of the biggies is eating grass, often to throw it up just a few minutes later. ANCIENT DNA REVEALS FATE OF THE MYSTERIOUS CANAANITES Ancient DNA reveals fate of the mysterious Canaanites. By Lizzie Wade Jul. 27, 2017 , 12:00 PM. When the pharaohs ruled Egypt and the ancient Greeks built their first cities, a mysterious people

IN THE PIPELINE

For many years now, the topic of “senescent cells” has been the subject of plenty of research work. Back in the 1960s the “Hayflick limit” was noticed in cell culture: there was an apparent limit to the number of cell divisions that could take place before the cells just sort of stalled out. NEWS | SCIENCE | AAAS Computers/Mathematics The internet goes quantum; Scientific Community NAS ousts member for first time, for sexual harassment; Latin American News Mexican funding agency forces out early-career JOURNALS | SCIENCE | AAAS Research. The Open Access journal Research, published in association with CAST, publishes innovative, wide-ranging research in life sciences, physical sciences, engineering and ACCESS AND SUBSCRIPTIONS Individual subscriptions are available for News from Science via our metered paywall. Please contact a AAAS MemberCentral Support associate by phone at: 202-326-6417 or toll free in the United ADDRESSING RACIAL INEQUITIES IN MEDICINE COVID-19 inequitably affects marginalized racial and ethnic populations across the world. A review of more than 17 million adult patients in the United Kingdom revealed a nearly twofold risk of death from COVID-19 among Black and Asian populations compared with white populations (). Black people comprise 12.5% of the US population, yet they account for more than 18% of COVID-19 CONTACT US | SCIENCE | AAAS Phone: 202-326- 6483. E-Mail: science_news@aaas.org. Contact information for individual news staff can be found on the Science Magazine Meet the News Staff page. Information regarding your

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READ THE LATEST ISSUE OF _SCIENCE_

4 JUNE 2021

Vol 372, Issue 6546

Table of Contents

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COMPUTERS/MATHEMATICS The internet goes quantum

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SCIENTIFIC COMMUNITY NAS ousts member for first time, for sexual harassment

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LATIN AMERICAN NEWS

Mexican funding agency forces out early-career researchers

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ECOLOGY

To study swarming cicadas, it takes a crowd

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EUROPEAN NEWS

Image sleuth faces legal threats

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SCIENCE AND POLICY

Applied research gets big role in Biden's budget

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