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WIKIPATHWAYS
WikiPathways is a database of biological pathways maintained by and for the scientific community. Read about our 12-year journey so far and official exit from beta or our 2021 NAR paper. MACROPHAGE MARKERS (HOMO SAPIENS) Overview of macrophage markers. Macrophages are cells within the tissues that originate from specific white blood cells called monocytes. Based on this list and tissue-specific gene expression from GeneAtlas.. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal GLYCEROPHOSPHOLIPID BIOSYNTHESIS (HOMO SAPIENS) From WikiPathways. Jump to: navigation, search 52, 83, 106, 129, 148 70, 149, 204 18, 19, 22, 49, 98 33, 82 121 2, 11, 34, 96, 115 81, 84,105, 134, 182 69
INTERLEUKIN-10 SIGNALING (HOMO SAPIENS) IL10 also enhances NK-cell proliferation and/or production of IFN-gamma (Cai et al. 1999). IL10-deficient mice exhibited inflammatory bowel disease (IBD) and other exaggerated inflammatory responses (Kuhn et al. 1993, Berg et al. 1995) indicating a critical role for IL10 in limiting inflammatory responses. Dysregulation ofIL10 is linked with
FLOWERING TIME PATHWAY (ARABIDOPSIS THALIANA) Flowering time pathway (Arabidopsis thaliana) NF-YA6 NF-YA5 NF-YA10 NF-YA9 NF-YA8 NF-YA1 NF-YA3 NF-YA2 NF-YA7 NF-YA4 43, 131 26, 136 18 11, 42, 62, 156, 170 34 3, 100 31, 173 4 6 SD Circadian clock Pfr PR COMPLEX Autonomous Pathway V GENE BASKET V V Go ahead! Help us move these interactors into the pathway FLOWERING NF-YA subunit 119 71, 111 AUTOPHAGY (HOMO SAPIENS) Autophagy is a type of process that cell allows itself to degrade intracellular components, including organelles, proteins and foreignbodies.
FATTY ACID OMEGA-OXIDATION (HOMO SAPIENS) Dodecanoate, or lauric acid, is found in the fats and oils of both plants and animals, especially coconut and palm kernel oil. Thispathway shows the
PHENYLALANINE BIOSYNTHESIS (SACCHAROMYCES CEREVISIAE Biosynthesis of the aromatic amino acids phenylalanine, tyrosine, and tryptophan proceeds via a common pathway to chorismate, at which point the pathway branches (CITS:). HEMATOPOIETIC STEM CELL DIFFERENTIATION (HOMO SAPIENS Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off VITAMIN D (CALCIFEROL) METABOLISM (HOMO SAPIENS Vitamin D3 (VD3, cholecalciferol) is a steroid hormone that principally plays roles in regulating intestinal calcium absorption and in bone metabolism.WIKIPATHWAYS
WikiPathways is a database of biological pathways maintained by and for the scientific community. Read about our 12-year journey so far and official exit from beta or our 2021 NAR paper. MACROPHAGE MARKERS (HOMO SAPIENS) Overview of macrophage markers. Macrophages are cells within the tissues that originate from specific white blood cells called monocytes. Based on this list and tissue-specific gene expression from GeneAtlas.. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal GLYCEROPHOSPHOLIPID BIOSYNTHESIS (HOMO SAPIENS) From WikiPathways. Jump to: navigation, search 52, 83, 106, 129, 148 70, 149, 204 18, 19, 22, 49, 98 33, 82 121 2, 11, 34, 96, 115 81, 84,105, 134, 182 69
INTERLEUKIN-10 SIGNALING (HOMO SAPIENS) IL10 also enhances NK-cell proliferation and/or production of IFN-gamma (Cai et al. 1999). IL10-deficient mice exhibited inflammatory bowel disease (IBD) and other exaggerated inflammatory responses (Kuhn et al. 1993, Berg et al. 1995) indicating a critical role for IL10 in limiting inflammatory responses. Dysregulation ofIL10 is linked with
FLOWERING TIME PATHWAY (ARABIDOPSIS THALIANA) Flowering time pathway (Arabidopsis thaliana) NF-YA6 NF-YA5 NF-YA10 NF-YA9 NF-YA8 NF-YA1 NF-YA3 NF-YA2 NF-YA7 NF-YA4 43, 131 26, 136 18 11, 42, 62, 156, 170 34 3, 100 31, 173 4 6 SD Circadian clock Pfr PR COMPLEX Autonomous Pathway V GENE BASKET V V Go ahead! Help us move these interactors into the pathway FLOWERING NF-YA subunit 119 71, 111 AUTOPHAGY (HOMO SAPIENS) Autophagy is a type of process that cell allows itself to degrade intracellular components, including organelles, proteins and foreignbodies.
FATTY ACID OMEGA-OXIDATION (HOMO SAPIENS) Dodecanoate, or lauric acid, is found in the fats and oils of both plants and animals, especially coconut and palm kernel oil. Thispathway shows the
PHENYLALANINE BIOSYNTHESIS (SACCHAROMYCES CEREVISIAE Biosynthesis of the aromatic amino acids phenylalanine, tyrosine, and tryptophan proceeds via a common pathway to chorismate, at which point the pathway branches (CITS:). HEMATOPOIETIC STEM CELL DIFFERENTIATION (HOMO SAPIENS Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off VITAMIN D (CALCIFEROL) METABOLISM (HOMO SAPIENS Vitamin D3 (VD3, cholecalciferol) is a steroid hormone that principally plays roles in regulating intestinal calcium absorption and in bone metabolism.DOWNLOAD PATHWAYS
rWikiPathways is an R package that provides an helper function called downloadPathwayArchive that will retrieve the latest file for you per species and format, e.g., downloadPathwayArchive (organism="Mus musculus”, format=‘gmt’) Filename pattern allows you to infer the filename of the latest collection given the current date.HELP:TUTORIAL
Introductory tutorial . WikiPathways Academy will teach you everything you need to know to start contributing to WikiPathways, from how to create a WikiPathways account, how to use our editing tools, and how to make your pathway public at WikiPathways. SARS-COV-2 B.1.1.7 VARIANT ANTAGONISES INNATE IMMUNE Bibliography . Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D; ''Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein.''; TGF-BETA SIGNALING PATHWAY (HOMO SAPIENS) The signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-β (TGF-β) have beenextensively
TNF-ALPHA SIGNALING PATHWAY (HOMO SAPIENS) From WikiPathways. Jump to: navigation, search Ca2+ Cytochrome C ROS ROS Cytochrome C TNF alpha Signaling Pathway Necrosis Apoptosis CY NU CY Procaspase 3/7 Ceramide Hydroperoxides PLA2 NU KSR2 TRAF2 RIPK1 BIRC2 MAPK9 BCL2L1 TNF REL BAX DIABLO BAD AKT1 NFKB2 MAP3K14 TAB3 RIPK1 KRAS PLK1 TAB1 GLUL Pro-CASP8 BIRC2 NRAS TXN TNFRSF1B CASP9NFKBIB MAPK1
RIPK1-MEDIATED REGULATED NECROSIS (HOMO SAPIENS Receptor-interacting serine/threonine-kinase protein 1 (RIPK1) and RIPK3-dependent necrosis is called necroptosis or programmed necrosis. The kinase activities of RIPK1 and RIPK3 are essential for the necroptotic cell death in human, mouse cell lines and genetic mice models (Cho YS et al. 2009; He S et al. 2009, 2011; Zhang DW et al. 2009; McQuade T et al. 2013; Newton et al. 2014). NGF PROCESSING (HOMO SAPIENS) Seidah NG, Benjannet S, Pareek S, Savaria D, Hamelin J, Goulet B, Laliberte J, Lazure C, Chrétien M, Murphy RA.; ''Cellular processing of the nerve growth factor precursor by TRANSLATION FACTORS (HOMO SAPIENS) Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. METHYLERYTHRITOL PHOSPHATE PATHWAY (ORYZA SATIVA In plants, the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway located in the plastids provides precursors for the isoprenoid hormones, monoterpenes, carotenoids and chlorophyll side chains, prenylquinones and tocopherol biosynthesis. OVERVIEW OF PROINFLAMMATORY AND PROFIBROTIC MEDIATORS Inflammatory cytokines leading to cytokine storm after NF-kappa-B and prostaglandin activation. KEGG pathway 05171 and a paper by Robb et al. was referenced for the pathway development.WIKIPATHWAYS
WikiPathways is a database of biological pathways maintained by and for the scientific community. Read about our 12-year journey so far and official exit from beta or our 2021 NAR paper. MACROPHAGE MARKERS (HOMO SAPIENS) Overview of macrophage markers. Macrophages are cells within the tissues that originate from specific white blood cells called monocytes. Based on this list and tissue-specific gene expression from GeneAtlas.. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal SELENIUM MICRONUTRIENT NETWORK (HOMO SAPIENS) Selenium micronutrient network (Homo sapiens) 185 65, 75, 83, 88, 111 163 18, 20, 24, 248 20 128, 265 59 53 185 64, 158, 185, 213 19, 150, 266 210 165 69, 88 9 205, 211 124, 208 124 175 100, 158, 159, 191 62 Other proteins Tryptophan metabolism Inflammation and immune response Cofactor conversion LEGEND Glycogenesis Metabolites Cleavage is FLOWERING TIME PATHWAY (ARABIDOPSIS THALIANA) Flowering time pathway (Arabidopsis thaliana) NF-YA6 NF-YA5 NF-YA10 NF-YA9 NF-YA8 NF-YA1 NF-YA3 NF-YA2 NF-YA7 NF-YA4 43, 131 26, 136 18 11, 42, 62, 156, 170 34 3, 100 31, 173 4 6 SD Circadian clock Pfr PR COMPLEX Autonomous Pathway V GENE BASKET V V Go ahead! Help us move these interactors into the pathway FLOWERING NF-YA subunit 119 71, 111 INTERLEUKIN-10 SIGNALING (HOMO SAPIENS) IL10 also enhances NK-cell proliferation and/or production of IFN-gamma (Cai et al. 1999). IL10-deficient mice exhibited inflammatory bowel disease (IBD) and other exaggerated inflammatory responses (Kuhn et al. 1993, Berg et al. 1995) indicating a critical role for IL10 in limiting inflammatory responses. Dysregulation ofIL10 is linked with
AUTOPHAGY (HOMO SAPIENS) Autophagy is a type of process that cell allows itself to degrade intracellular components, including organelles, proteins and foreignbodies.
FATTY ACID OMEGA-OXIDATION (HOMO SAPIENS) Dodecanoate, or lauric acid, is found in the fats and oils of both plants and animals, especially coconut and palm kernel oil. Thispathway shows the
OXYSTEROLS DERIVED FROM CHOLESTEROL (HOMO SAPIENS The Oxysterol group of compounds are oxygenated derivatives of cholesterol or its sterol precursors, e.g. 7-dehydrocholesterol (7-DHC) or desmosterol. There are three mechanisms leading to the formation of oxysterols: 1. HEMATOPOIETIC STEM CELL DIFFERENTIATION (HOMO SAPIENS Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off VITAMIN D (CALCIFEROL) METABOLISM (HOMO SAPIENS Vitamin D3 (VD3, cholecalciferol) is a steroid hormone that principally plays roles in regulating intestinal calcium absorption and in bone metabolism.WIKIPATHWAYS
WikiPathways is a database of biological pathways maintained by and for the scientific community. Read about our 12-year journey so far and official exit from beta or our 2021 NAR paper. MACROPHAGE MARKERS (HOMO SAPIENS) Overview of macrophage markers. Macrophages are cells within the tissues that originate from specific white blood cells called monocytes. Based on this list and tissue-specific gene expression from GeneAtlas.. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal SELENIUM MICRONUTRIENT NETWORK (HOMO SAPIENS) Selenium micronutrient network (Homo sapiens) 185 65, 75, 83, 88, 111 163 18, 20, 24, 248 20 128, 265 59 53 185 64, 158, 185, 213 19, 150, 266 210 165 69, 88 9 205, 211 124, 208 124 175 100, 158, 159, 191 62 Other proteins Tryptophan metabolism Inflammation and immune response Cofactor conversion LEGEND Glycogenesis Metabolites Cleavage is FLOWERING TIME PATHWAY (ARABIDOPSIS THALIANA) Flowering time pathway (Arabidopsis thaliana) NF-YA6 NF-YA5 NF-YA10 NF-YA9 NF-YA8 NF-YA1 NF-YA3 NF-YA2 NF-YA7 NF-YA4 43, 131 26, 136 18 11, 42, 62, 156, 170 34 3, 100 31, 173 4 6 SD Circadian clock Pfr PR COMPLEX Autonomous Pathway V GENE BASKET V V Go ahead! Help us move these interactors into the pathway FLOWERING NF-YA subunit 119 71, 111 INTERLEUKIN-10 SIGNALING (HOMO SAPIENS) IL10 also enhances NK-cell proliferation and/or production of IFN-gamma (Cai et al. 1999). IL10-deficient mice exhibited inflammatory bowel disease (IBD) and other exaggerated inflammatory responses (Kuhn et al. 1993, Berg et al. 1995) indicating a critical role for IL10 in limiting inflammatory responses. Dysregulation ofIL10 is linked with
AUTOPHAGY (HOMO SAPIENS) Autophagy is a type of process that cell allows itself to degrade intracellular components, including organelles, proteins and foreignbodies.
FATTY ACID OMEGA-OXIDATION (HOMO SAPIENS) Dodecanoate, or lauric acid, is found in the fats and oils of both plants and animals, especially coconut and palm kernel oil. Thispathway shows the
OXYSTEROLS DERIVED FROM CHOLESTEROL (HOMO SAPIENS The Oxysterol group of compounds are oxygenated derivatives of cholesterol or its sterol precursors, e.g. 7-dehydrocholesterol (7-DHC) or desmosterol. There are three mechanisms leading to the formation of oxysterols: 1. HEMATOPOIETIC STEM CELL DIFFERENTIATION (HOMO SAPIENS Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off VITAMIN D (CALCIFEROL) METABOLISM (HOMO SAPIENS Vitamin D3 (VD3, cholecalciferol) is a steroid hormone that principally plays roles in regulating intestinal calcium absorption and in bone metabolism. A NETWORK MAP OF SARS-COV-2 SIGNALING PATHWAY (HOMO from wikipathways. jump to: navigation, search 2 4 22 11 15 21 11 5 10 5 15 13 18 12 10 viral entry into cells cytochrome c sars-cov-2 s ace2 k702 k625 7, 9, 19 tmprss2 3 sars-cov-2 os9 mark2 tbkbp1 clcc1 fam98a sigmar1 erlec1 tle1 sdf2 gtf2f2 uggt2 nek9 g3bp2 nptx1 atp6ap1 tle3 atp13a3 mov10 upf1 tle5 adam9 g3bp1 mib1 srp72 srp54 srp19 ate1 ggh larp1 mdn1 tomm70 trim59 nsp6 orf7b 7, 8 orf3a 7 SELENIUM MICRONUTRIENT NETWORK (HOMO SAPIENS) Selenium micronutrient network (Homo sapiens) 185 65, 75, 83, 88, 111 163 18, 20, 24, 248 20 128, 265 59 53 185 64, 158, 185, 213 19, 150, 266 210 165 69, 88 9 205, 211 124, 208 124 175 100, 158, 159, 191 62 Other proteins Tryptophan metabolism Inflammation and immune response Cofactor conversion LEGEND Glycogenesis Metabolites Cleavage is NUCLEAR RECEPTORS META-PATHWAY (HOMO SAPIENS) Nuclear Receptors Meta-Pathway (Homo sapiens) 10, 48 CAR/PXR Ligand CAR target genes Other Other Other Other Other 50 17 17 9 CES3 FGF19 CES5A CYP2A6 PTGS2 Antioxidant proteins SLC2A12 EHHADH ZIC2 UGT2B7 CYP4A11 SEC14L1 SLC2A8 RGS2 Bile acid & xenobiotics transport PDE4B PPP1R14C UGT1A7 PDK4 ABCB11 PPP2R4 PPARGC1A SRGN PTGR1 PRRG4 CYP1B1CYP2B6
FATTY ACID OMEGA-OXIDATION (HOMO SAPIENS) Dodecanoate, or lauric acid, is found in the fats and oils of both plants and animals, especially coconut and palm kernel oil. Thispathway shows the
IL-7 SIGNALING PATHWAY (HOMO SAPIENS) Name Type Database reference Comment; AKT1: Protein: 207 (Entrez Gene) BAD: Protein: 572 (Entrez Gene) BCL2L1: Rna: 598 (Entrez Gene) CCND1: Rna: 595 (Entrez Gene) CDKN1B OXYSTEROLS DERIVED FROM CHOLESTEROL (HOMO SAPIENS The Oxysterol group of compounds are oxygenated derivatives of cholesterol or its sterol precursors, e.g. 7-dehydrocholesterol (7-DHC) or desmosterol. There are three mechanisms leading to the formation of oxysterols: 1. RIPK1-MEDIATED REGULATED NECROSIS (HOMO SAPIENS Receptor-interacting serine/threonine-kinase protein 1 (RIPK1) and RIPK3-dependent necrosis is called necroptosis or programmed necrosis. The kinase activities of RIPK1 and RIPK3 are essential for the necroptotic cell death in human, mouse cell lines and genetic mice models (Cho YS et al. 2009; He S et al. 2009, 2011; Zhang DW et al. 2009; McQuade T et al. 2013; Newton et al. 2014). AEROBIC GLYCOLYSIS (HOMO SAPIENS) Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. MECP2 AND ASSOCIATED RETT SYNDROME (HOMO SAPIENS MECP2 (methyl-CpG binding protein 2) is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, andglial cells.
NEUTROPHIL DEGRANULATION (HOMO SAPIENS) Neutrophil degranulation (Homo sapiens) 4, 8, 11, 12, 17 8 4 4 8 4 4 4 4 4 4 secretory granule lumen specific granule lumen azurophil granule lumen cytosol ficolin-1-rich granule lumen tertiary granule lumen VCL TSPAN14 PECAM1 CD47 PSMD1 CTSD (65-412) GSDMD MMP9 PSMD12 FCER1G GGH HK3 TSPAN14 OSCAR CR1 ATP6V0C PRG3 IMPDH2 LAMTOR2 COPB1 PSMD3WIKIPATHWAYS
FROM WIKIPATHWAYS
Jump to: navigation, search SHARE YOUR PATHWAY KNOWLEDGE IN THE FIGHT AGAINST COVID-19 _ACCESS_ THE RAPIDLY GROWING COLLECTION OF COVID-19 PATHWAYS , _CONTRIBUTE_ YOUR TIME AND DOMAIN KNOWLEDGE ABOUT PATHWAY BIOLOGY AS A PATHWAY AUTHOR , AND _USE_ THESE PATHWAYS IN YOUR RESEARCH.
WELCOME TO WIKIPATHWAYS WIKIPATHWAYS IS A DATABASE OF BIOLOGICAL PATHWAYS MAINTAINED BY AND FOR THE SCIENTIFIC COMMUNITY. _Read about our 12-year journey so far and official exit from beta or our 2021 NAR paper_
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QUEUE FIGURES FOR CONVERSION WE WANT YOUR FEEDBACK! A QUICK SURVEY TO HELP US FOCUS DEVELOPMENT: HTTPS://WWW.SURVEYMONKEY.COM/R/WIKIPATHWAYS TODAY'S FEATURED PATHWAY SARS-CoV-2 and angiotensin-converting enzyme 2 receptor: molecular mechanisms (Homo sapiens) SARS-CoV-2 and angiotensin-converting enzyme 2 receptor: molecularmechanisms
CURATOR OF THE WEEK
Marvin Martens (Maastricht University)UPDATES
* MAY 2021 RELEASE: 531 editsby 27 contributors
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DISCUSSIONS
1 June 2021
Status of pathway? (2) by Kristina Hanspers24 May 2021
Caf-1/ccr4 deadenylation complex (1)by david A romine
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