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Text
OncoImmune’
HOT TOPICS | IUPHAR/BPS GUIDE TO PHARMACOLOGY Hot Topics: Virtual screening on the crystal structure of the G protein-coupled melatonin MT1 receptor reveals several new chemical scaffolds with biological activity. Comments by Ralf Jockers, Institut Cochin, CNRS, INSERM, Université de Paris, Paris, France, Chair for NC-IUPHAR Subcommitee for Melatonin receptors. NOMENCLATURE GUIDELINES TARGETS | IUPHAR/BPS GUIDE TO PHARMACOLOGY The IUPHAR/BPS Guide to PHARMACOLOGY target list. G protein-coupled receptors (GPCRs), voltage- and ligand-gated ion channels, nuclear hormone receptors, catalytic receptors, enzymes, transporters and other protein targets.ABOUT NC-IUPHAR
USEFUL LINKS
Marine Pharmacology (Midwestern University): a website aimed at those with an interest in the preclinical and clinical pharmacology of marine compounds and the pharmaceutical potential of the enormous biodiversity of organisms present in the world's oceans. ZINC: A database containing commercially available compounds for structure-based virtual GUIDE TO PHARMACOLOGY Guide to PHARMACOLOGYDOWNLOAD SLIDES
We have produced a set of generic slides (now updated for end 2018) for public use when producing presentations and teaching materials on the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb). The slide set is divided up into sections which can be mixed and matched as required. The slides cover the background and history of the database, about NC NOMENCLATURE OF LIGAND-GATED ION CHANNELS The nomenclature of individual families of ligand-gated ion channels (LGICs) has developed independently since these receptors were first identified, resulting in a variety of nomenclature systems. As we no longer expect to discover large numbers of LGIC receptor subunits in the human genome, but are continuing to find heteromeric receptor GTOPDB GENERIC SLIDES Contents • Background and history of the database • About NC-IUPHAR • Database content • Navigating the website and search tools • Recent additions and expansions • The Concise Guide to PHARMACOLOGY • The IUPHAR Guide to IMMUNOPHARMACOLOGY • The IUPHAR/MMV Guide to MALARIA PHARMACOLOGY • Additional features and resources • The Pharmacology Education Project HOME | IUPHAR/BPS GUIDE TO PHARMACOLOGYABOUTTARGETSRESOURCESSPONSORSDISCLAIMERDOWNLOAD SLIDES GtoPdb pre-release ligands (2021.1) These are some of the ligands under curation (pre-release) in the Guide to Pharmacology. We expect them to be available on the website at the next database release (2021.1). Ligand ID: 11395Names: MK-7110Comment: MK-7110 (originallyOncoImmune’
HOT TOPICS | IUPHAR/BPS GUIDE TO PHARMACOLOGY Hot Topics: Virtual screening on the crystal structure of the G protein-coupled melatonin MT1 receptor reveals several new chemical scaffolds with biological activity. Comments by Ralf Jockers, Institut Cochin, CNRS, INSERM, Université de Paris, Paris, France, Chair for NC-IUPHAR Subcommitee for Melatonin receptors. NOMENCLATURE GUIDELINES TARGETS | IUPHAR/BPS GUIDE TO PHARMACOLOGY The IUPHAR/BPS Guide to PHARMACOLOGY target list. G protein-coupled receptors (GPCRs), voltage- and ligand-gated ion channels, nuclear hormone receptors, catalytic receptors, enzymes, transporters and other protein targets.ABOUT NC-IUPHAR
USEFUL LINKS
Marine Pharmacology (Midwestern University): a website aimed at those with an interest in the preclinical and clinical pharmacology of marine compounds and the pharmaceutical potential of the enormous biodiversity of organisms present in the world's oceans. ZINC: A database containing commercially available compounds for structure-based virtual GUIDE TO PHARMACOLOGY Guide to PHARMACOLOGYDOWNLOAD SLIDES
We have produced a set of generic slides (now updated for end 2018) for public use when producing presentations and teaching materials on the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb). The slide set is divided up into sections which can be mixed and matched as required. The slides cover the background and history of the database, about NC NOMENCLATURE OF LIGAND-GATED ION CHANNELS The nomenclature of individual families of ligand-gated ion channels (LGICs) has developed independently since these receptors were first identified, resulting in a variety of nomenclature systems. As we no longer expect to discover large numbers of LGIC receptor subunits in the human genome, but are continuing to find heteromeric receptor GTOPDB GENERIC SLIDES Contents • Background and history of the database • About NC-IUPHAR • Database content • Navigating the website and search tools • Recent additions and expansions • The Concise Guide to PHARMACOLOGY • The IUPHAR Guide to IMMUNOPHARMACOLOGY • The IUPHAR/MMV Guide to MALARIA PHARMACOLOGY • Additional features and resources • The Pharmacology Education Project ABOUT | IUPHAR/BPS GUIDE TO PHARMACOLOGY The International Union of Basic and Clinical Pharmacology (IUPHAR) / British Pharmacological Society (BPS) Guide to PHARMACOLOGY is an expert-curated resource of ligand-activity-target relationships, the majority of which come from high-quality pharmacological and medicinal chemistry literature. TARGET AND DRUG LISTS In parallel with the target lists we offer users a selection of attributed drug lists, in the broad sense of encompassing approved, clinical or research small-molecules, together with biologicals in some cases. These have been downloaded from databases or extracted as supplementary data from journal papers. We much appreciate their availability but note they are supplied as-is. DOWNLOAD | IUPHAR/BPS GUIDE TO PHARMACOLOGY The current list of Guide to PHARMACOLOGY cross-references in UniProtKB.Note these are the 2069 protein accessions (from the three species human, mouse and rat) that have quantitative interactions (with affinity > 6) with any of the ~10,500 ligands, including approved drugs, research compounds as well as endogenous ligands, mapped to GtoPdb target identifiers. TARGETS | IUPHAR/BPS GUIDE TO PHARMACOLOGY The IUPHAR/BPS Guide to PHARMACOLOGY target list. G protein-coupled receptors (GPCRs), voltage- and ligand-gated ion channels, nuclear hormone receptors, catalytic receptors, enzymes, transporters and other protein targets.LINKING TO US
Overview. This page provides information on how to link to database pages on the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) and is aimed at authors needing to add links from journal articles, and also database developers wishing to map lists of entities to entries in GtoPdb.LATEST PAIRINGS
C3a receptor & VGF derived peptide TLQP-21. "A recent report concerning a peptide derived from the vgf gene product, TLQP-21, is suggestive of an interaction with C3a receptor in rodents. However, in competition binding assays the affinity of TLQP-21 is comparatively low for a peptide-GPCR interaction, where sub-nanomolar affinities areusual.
DOWNLOAD SLIDES
We have produced a set of generic slides (now updated for end 2018) for public use when producing presentations and teaching materials on the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb). The slide set is divided up into sections which can be mixed and matched as required. The slides cover the background and history of the database, about NC GUIDETOPHARMACOLOGY BLOG Here are the details for the first release in 2021 of the Guide to PHARMACOLOGY database, version 2021.1. This is the last release before we move forward with the process of preparing the next edition of the Concise Guide to Pharmacology (2021/22). As such, the release contains many updates specifically with the CGTP in mind. NOMENCLATURE OF LIGAND-GATED ION CHANNELS The nomenclature of individual families of ligand-gated ion channels (LGICs) has developed independently since these receptors were first identified, resulting in a variety of nomenclature systems. As we no longer expect to discover large numbers of LGIC receptor subunits in the human genome, but are continuing to find heteromeric receptor HOME | IUPHAR/BPS GUIDE TO PHARMACOLOGYWEB VIEW 1380836 4 2009 2009. 675639 4 1975. 139286 4 1974 1984. 2393 4 1939. 181939 4 1987 1985. 622436 4 2004. 619 4 1979 1983. 27639 4 2000 2001. 604622 4 1993 1994. 33809 4 1957. 16584 4 1957. 94571 HOME | IUPHAR/BPS GUIDE TO PHARMACOLOGYABOUTTARGETSRESOURCESSPONSORSDISCLAIMERDOWNLOAD SLIDES Database version 2021.1 (18th Mar 21) - read release details in our blog. GM-CSF added to coronavirus targets lists - a principal marker of severe COVID-19 immunopathology. New coronavirus linked ligands include ensovibep (MP0420), emovododstat & MK-7110.; 220 ligands since last update, all curated with peptide or chemical structures NOMENCLATURE GUIDELINES HOT TOPICS | IUPHAR/BPS GUIDE TO PHARMACOLOGY The IUPHAR/BPS Guide to PHARMACOLOGY Hot Topics. Hot topics in pharmacology and recent papers recommended by NC-IUPHAR. TARGETS | IUPHAR/BPS GUIDE TO PHARMACOLOGY The IUPHAR/BPS Guide to PHARMACOLOGY target list. G protein-coupled receptors (GPCRs), voltage- and ligand-gated ion channels, nuclear hormone receptors, catalytic receptors, enzymes, transporters and other protein targets.USEFUL LINKS
Databases of drugs and drug targets. BindingDB: The Binding Database; ChEMBL: medicinal chemistry and drug discovery databases; DrugBank: detailed information on drugs and the protein sequences they interact with.Note that DrugBank is free for academic and nonABOUT NC-IUPHAR
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Generic slide set. We have produced a set of generic slides (now updated for end 2018) for public use when producing presentations and teaching materials on GUIDE TO PHARMACOLOGY Guide to PHARMACOLOGY NOMENCLATURE OF LIGAND-GATED ION CHANNELS The nomenclature of individual families of ligand-gated ion channels (LGICs) has developed independently since these receptors were first identified, resulting in a variety of nomenclature systems. GTOPDB GENERIC SLIDES Contents • Background and history of the database • About NC-IUPHAR • Database content • Navigating the website and search tools • Recent additions and expansions • The Concise Guide to PHARMACOLOGY • The IUPHAR Guide to IMMUNOPHARMACOLOGY • The IUPHAR/MMV Guide to MALARIA PHARMACOLOGY • Additional features and resources • The Pharmacology Education Project HOME | IUPHAR/BPS GUIDE TO PHARMACOLOGYABOUTTARGETSRESOURCESSPONSORSDISCLAIMERDOWNLOAD SLIDES Database version 2021.1 (18th Mar 21) - read release details in our blog. GM-CSF added to coronavirus targets lists - a principal marker of severe COVID-19 immunopathology. New coronavirus linked ligands include ensovibep (MP0420), emovododstat & MK-7110.; 220 ligands since last update, all curated with peptide or chemical structures NOMENCLATURE GUIDELINES HOT TOPICS | IUPHAR/BPS GUIDE TO PHARMACOLOGY The IUPHAR/BPS Guide to PHARMACOLOGY Hot Topics. Hot topics in pharmacology and recent papers recommended by NC-IUPHAR. TARGETS | IUPHAR/BPS GUIDE TO PHARMACOLOGY The IUPHAR/BPS Guide to PHARMACOLOGY target list. G protein-coupled receptors (GPCRs), voltage- and ligand-gated ion channels, nuclear hormone receptors, catalytic receptors, enzymes, transporters and other protein targets.USEFUL LINKS
Databases of drugs and drug targets. BindingDB: The Binding Database; ChEMBL: medicinal chemistry and drug discovery databases; DrugBank: detailed information on drugs and the protein sequences they interact with.Note that DrugBank is free for academic and nonABOUT NC-IUPHAR
DOWNLOAD SLIDES
Generic slide set. We have produced a set of generic slides (now updated for end 2018) for public use when producing presentations and teaching materials on GUIDE TO PHARMACOLOGY Guide to PHARMACOLOGY NOMENCLATURE OF LIGAND-GATED ION CHANNELS The nomenclature of individual families of ligand-gated ion channels (LGICs) has developed independently since these receptors were first identified, resulting in a variety of nomenclature systems. GTOPDB GENERIC SLIDES Contents • Background and history of the database • About NC-IUPHAR • Database content • Navigating the website and search tools • Recent additions and expansions • The Concise Guide to PHARMACOLOGY • The IUPHAR Guide to IMMUNOPHARMACOLOGY • The IUPHAR/MMV Guide to MALARIA PHARMACOLOGY • Additional features and resources • The Pharmacology Education Project ABOUT | IUPHAR/BPS GUIDE TO PHARMACOLOGY The International Union of Basic and Clinical Pharmacology (IUPHAR) / British Pharmacological Society (BPS) Guide to PHARMACOLOGY is an expert-curated resource of ligand-activity-target relationships, the majority of which come from high-quality pharmacological and medicinal chemistry literature. DOWNLOAD | IUPHAR/BPS GUIDE TO PHARMACOLOGY The current list of Guide to PHARMACOLOGY cross-references in UniProtKB.Note these are the 2069 protein accessions (from the three species human, mouse and rat) that have quantitative interactions (with affinity > 6) with any of the ~10,500 ligands, including approved drugs, research compounds as well as endogenous ligands, mapped to GtoPdb target identifiers. TARGET AND DRUG LISTS In parallel with the target lists we offer users a selection of attributed drug lists, in the broad sense of encompassing approved, clinical or research small-molecules, together with biologicals in some cases. These have been downloaded from databases or extracted as supplementary data from journal papers. We much appreciate their availability but note they are supplied as-is. BLAST | IUPHAR/BPS GUIDE TO PHARMACOLOGY Sponsors list. This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International LicenseCreative Commons Attribution-ShareAlike 4.0 International LicenseDOWNLOAD SLIDES
Generic slide set. We have produced a set of generic slides (now updated for end 2018) for public use when producing presentations and teaching materials onLINKING TO US
This page provides information on how to link to database pages on the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) and is aimed at authors needing to add links from journal articles, and also database developers wishing to map lists of entities to entries in GtoPdb. GUIDETOPHARMACOLOGY BLOG Here are the details for the first release in 2021 of the Guide to PHARMACOLOGY database, version 2021.1. This is the last release before we move forward with the process of preparing the next edition of the Concise Guide to Pharmacology (2021/22). FAQ | IUPHAR/BPS GUIDE TO PHARMACOLOGY The IUPHAR/BPS Guide to PHARMACOLOGY FAQ. Explanation of database content and curatorial policy. NOMENCLATURE OF LIGAND-GATED ION CHANNELS The nomenclature of individual families of ligand-gated ion channels (LGICs) has developed independently since these receptors were first identified, resulting in a variety of nomenclature systems.HOME - SYNPHARM
SynPharm is a database of drug-responsive protein sequences, derived from the IUPHAR/BPS Guide to PHARMACOLOGY. HOME | IUPHAR/BPS GUIDE TO PHARMACOLOGYABOUTTARGETSRESOURCESSPONSORSDISCLAIMERDOWNLOAD SLIDES GtoPdb pre-release ligands (2021.1) These are some of the ligands under curation (pre-release) in the Guide to Pharmacology. We expect them to be available on the website at the next database release (2021.1). Ligand ID: 11395Names: MK-7110Comment: MK-7110 (originallyOncoImmune’
NOMENCLATURE GUIDELINES HOT TOPICS | IUPHAR/BPS GUIDE TO PHARMACOLOGYIUPHAR BPS GUIDE TO PHARMACOLOGYFREE PHARMACOLOGY STUDY GUIDEPRINTABLE PHARMACOLOGY STUDY GUIDESTUDY GUIDE FOR PHARMACOLOGYBASIC PHARMACOLOGY STUDY GUIDE Hot Topics: Virtual screening on the crystal structure of the G protein-coupled melatonin MT1 receptor reveals several new chemical scaffolds with biological activity. Comments by Ralf Jockers, Institut Cochin, CNRS, INSERM, Université de Paris, Paris, France, Chair for NC-IUPHAR Subcommitee for Melatonin receptors. GUIDE TO PHARMACOLOGY Guide to PHARMACOLOGY TARGETS | IUPHAR/BPS GUIDE TO PHARMACOLOGY The IUPHAR/BPS Guide to PHARMACOLOGY target list. G protein-coupled receptors (GPCRs), voltage- and ligand-gated ion channels, nuclear hormone receptors, catalytic receptors, enzymes, transporters and other protein targets. GTOPDB GENERIC SLIDES Contents • Background and history of the database • About NC-IUPHAR • Database content • Navigating the website and search tools • Recent additions and expansions • The Concise Guide to PHARMACOLOGY • The IUPHAR Guide to IMMUNOPHARMACOLOGY • The IUPHAR/MMV Guide to MALARIA PHARMACOLOGY • Additional features and resources • The Pharmacology Education ProjectABOUT NC-IUPHAR
ABOUT | IUPHAR/BPS GUIDE TO PHARMACOLOGYIUPHAR BPS GUIDE TO PHARMACOLOGYSTUDY GUIDE FOR PHARMACOLOGYINTRODUCTION TO PHARMACOLOGY PDFINTRO TO CLINICAL PHARMACOLOGYPHARMACOLOGY REFERENCE GUIDEINTERNATIONAL UNION OF BASIC AND CLINICAL PH… The International Union of Basic and Clinical Pharmacology (IUPHAR) / British Pharmacological Society (BPS) Guide to PHARMACOLOGY is an expert-curated resource of ligand-activity-target relationships, the majority of which come from high-quality pharmacological and medicinal chemistry literature. DOWNLOAD | IUPHAR/BPS GUIDE TO PHARMACOLOGY The current list of Guide to PHARMACOLOGY cross-references in UniProtKB.Note these are the 2069 protein accessions (from the three species human, mouse and rat) that have quantitative interactions (with affinity > 6) with any of the ~10,500 ligands, including approved drugs, research compounds as well as endogenous ligands, mapped to GtoPdb target identifiers. SPONSORS | IUPHAR/BPS GUIDE TO PHARMACOLOGYIUPHAR BPS GUIDE TO PHARMACOLOGYSTUDY GUIDE FOR PHARMACOLOGYINTRODUCTION TO PHARMACOLOGY PDFINTRO TO CLINICAL PHARMACOLOGYPHARMACOLOGY DRUG GUIDEPHARMACOLOGYSTUDY GUIDE NURSING
The IUPHAR/BPS Guide to PHARMACOLOGY Sponsor List. Antibiotic DB is the first free, open-access database of antibacterial compounds, including discontinued agents, drugs under pre-clinical development and those in clinical trials. GtoPdb and Antibiotic DB are collaborating to help improve antibiotic compound coverage in GtoPdb, and to provide reciprocal links between the two resources. HOME | IUPHAR/BPS GUIDE TO PHARMACOLOGYABOUTTARGETSRESOURCESSPONSORSDISCLAIMERDOWNLOAD SLIDES GtoPdb pre-release ligands (2021.1) These are some of the ligands under curation (pre-release) in the Guide to Pharmacology. We expect them to be available on the website at the next database release (2021.1). Ligand ID: 11395Names: MK-7110Comment: MK-7110 (originallyOncoImmune’
NOMENCLATURE GUIDELINES HOT TOPICS | IUPHAR/BPS GUIDE TO PHARMACOLOGYIUPHAR BPS GUIDE TO PHARMACOLOGYFREE PHARMACOLOGY STUDY GUIDEPRINTABLE PHARMACOLOGY STUDY GUIDESTUDY GUIDE FOR PHARMACOLOGYBASIC PHARMACOLOGY STUDY GUIDE Hot Topics: Virtual screening on the crystal structure of the G protein-coupled melatonin MT1 receptor reveals several new chemical scaffolds with biological activity. Comments by Ralf Jockers, Institut Cochin, CNRS, INSERM, Université de Paris, Paris, France, Chair for NC-IUPHAR Subcommitee for Melatonin receptors. GUIDE TO PHARMACOLOGY Guide to PHARMACOLOGY TARGETS | IUPHAR/BPS GUIDE TO PHARMACOLOGY The IUPHAR/BPS Guide to PHARMACOLOGY target list. G protein-coupled receptors (GPCRs), voltage- and ligand-gated ion channels, nuclear hormone receptors, catalytic receptors, enzymes, transporters and other protein targets. GTOPDB GENERIC SLIDES Contents • Background and history of the database • About NC-IUPHAR • Database content • Navigating the website and search tools • Recent additions and expansions • The Concise Guide to PHARMACOLOGY • The IUPHAR Guide to IMMUNOPHARMACOLOGY • The IUPHAR/MMV Guide to MALARIA PHARMACOLOGY • Additional features and resources • The Pharmacology Education ProjectABOUT NC-IUPHAR
ABOUT | IUPHAR/BPS GUIDE TO PHARMACOLOGYIUPHAR BPS GUIDE TO PHARMACOLOGYSTUDY GUIDE FOR PHARMACOLOGYINTRODUCTION TO PHARMACOLOGY PDFINTRO TO CLINICAL PHARMACOLOGYPHARMACOLOGY REFERENCE GUIDEINTERNATIONAL UNION OF BASIC AND CLINICAL PH… The International Union of Basic and Clinical Pharmacology (IUPHAR) / British Pharmacological Society (BPS) Guide to PHARMACOLOGY is an expert-curated resource of ligand-activity-target relationships, the majority of which come from high-quality pharmacological and medicinal chemistry literature. DOWNLOAD | IUPHAR/BPS GUIDE TO PHARMACOLOGY The current list of Guide to PHARMACOLOGY cross-references in UniProtKB.Note these are the 2069 protein accessions (from the three species human, mouse and rat) that have quantitative interactions (with affinity > 6) with any of the ~10,500 ligands, including approved drugs, research compounds as well as endogenous ligands, mapped to GtoPdb target identifiers. SPONSORS | IUPHAR/BPS GUIDE TO PHARMACOLOGYIUPHAR BPS GUIDE TO PHARMACOLOGYSTUDY GUIDE FOR PHARMACOLOGYINTRODUCTION TO PHARMACOLOGY PDFINTRO TO CLINICAL PHARMACOLOGYPHARMACOLOGY DRUG GUIDEPHARMACOLOGYSTUDY GUIDE NURSING
The IUPHAR/BPS Guide to PHARMACOLOGY Sponsor List. Antibiotic DB is the first free, open-access database of antibacterial compounds, including discontinued agents, drugs under pre-clinical development and those in clinical trials. GtoPdb and Antibiotic DB are collaborating to help improve antibiotic compound coverage in GtoPdb, and to provide reciprocal links between the two resources. DOWNLOAD | IUPHAR/BPS GUIDE TO PHARMACOLOGY The current list of Guide to PHARMACOLOGY cross-references in UniProtKB.Note these are the 2069 protein accessions (from the three species human, mouse and rat) that have quantitative interactions (with affinity > 6) with any of the ~10,500 ligands, including approved drugs, research compounds as well as endogenous ligands, mapped to GtoPdb target identifiers. TARGET AND DRUG LISTS The comprehensive list includes 461 targets of approved drugs. Download list. A 3-way consensus list from the paper "Comparing the Chemical Structure and Protein Content of ChEMBL, DrugBank, Human Metabolome Database and the Therapeutic Target Database" (2013) . The 352 are proteins-in-common between the three drugdatabases.
DOWNLOAD SLIDES
We have produced a set of generic slides (now updated for end 2018) for public use when producing presentations and teaching materials on the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb). The slide set is divided up into sections which can be mixed and matched as required. The slides cover the background and history of the database, about NCUSEFUL LINKS
Marine Pharmacology (Midwestern University): a website aimed at those with an interest in the preclinical and clinical pharmacology of marine compounds and the pharmaceutical potential of the enormous biodiversity of organisms present in the world's oceans. ZINC: A database containing commercially available compounds for structure-based virtualLINKING TO US
Overview. This page provides information on how to link to database pages on the IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) and is aimed at authors needing to add links from journal articles, and also database developers wishing to map lists of entities to entries in GtoPdb. FAQ | IUPHAR/BPS GUIDE TO PHARMACOLOGY The increasing importance of splice variants in pharmacology is recognised in this recent IUPHAR review ( PMID 24670145 ). Future updates may thus include splice-specific binding data. If the splice variant is clearly defined in the paper we should be able to matchthis
GUIDETOPHARMACOLOGY BLOG Here are the details for the first release in 2021 of the Guide to PHARMACOLOGY database, version 2021.1. This is the last release before we move forward with the process of preparing the next edition of the Concise Guide to Pharmacology (2021/22). As such, the release contains many updates specifically with the CGTP in mind. NOMENCLATURE OF LIGAND-GATED ION CHANNELS The nomenclature of individual families of ligand-gated ion channels (LGICs) has developed independently since these receptors were first identified, resulting in a variety of nomenclature systems. As we no longer expect to discover large numbers of LGIC receptor subunits in the human genome, but are continuing to find heteromeric receptorHOME - SYNPHARM
Home - SynPharm. SynPharm is a database of drug-responsive protein sequences, derived from the IUPHAR/BPS Guide to PHARMACOLOGY . HOME | IUPHAR/BPS GUIDE TO PHARMACOLOGY Home | IUPHAR/BPS Guide to PHARMACOLOGY* Home
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Tweets by @GuidetoPHARM WHAT'S NEW TO GUIDE TO PHARMACOLOGY READ OUR LATEST DATABASE REPORT (APR 2021) - download/view PDF ------------------------- DATABASE VERSION 2021.1 (18TH MAR 21) - READ RELEASE DETAILS IN OURBLOG
* GM-CSF added to
coronavirus targets lists - a principal marker of severe COVID-19 immunopathology. New coronavirus linked ligands include ensovibep (MP0420) , emovododstat& MK-7110
.
* 220 ligands since last update, all curated with peptide orchemical structures
* New family of enzymes, Peptidyl-prolyl cis/trans isomerases(PPIases)
,
has been added, including in particular those that are therapeutictargets.
* New download files: Ligands in SDF format and mapping file of GtoPdb ligand IDs to external ligand identifiers - see our downloadspage .
* Ligand links to Reactome - both for reactions and drug entities * Total curated anti-malarial ligands now stands at 105. There are now 37 anti-malarial targets , organised into subfamilies CORONAVIRUS INFORMATION CORONAVIRUS (COVID-19) INFORMATION PAGE - view our information page which summarises ligands and drug targets relevant in pharmacological strategies to mitigate against COVID-19. LATEST NEWS AND HOT TOPICS IN PHARMACOLOGY powered by Surfing Waves All news Our blog Hot topicsLatest pairings
PHARMACOLOGY OF COVID-19THEMED ISSUE IN BJP
This themed issue includes IUPHAR REVIEW 29: A RATIONAL ROADMAP FOR SARS‐COV‐2/COVID‐19 PHARMACOTHERAPEUTIC RESEARCH AND DEVELOPMENT, which
made the cover of the issue. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20 ACCESS THE TABLE OF CONTENTS Please see the 5 minute introductory video on the Concise Guide:RECENT PUBLICATIONS
COVID-19 AND THE REVIVAL OF PASSIVE IMMUNIZATION: ANTIBODY THERAPY FOR INHIBITING SARS-COV-2 AND PREVENTING HOST CELL INFECTION: IUPHARREVIEW: 31
Levi-Schaffer F, de Marco A (2021) _Br J Pharmacol._ Online ahead of print. doi: 10.1111/bph.15359. UPDATE OF P2X RECEPTOR PROPERTIES AND THEIR PHARMACOLOGY: IUPHARREVIEW 30
Illes P, Müller CE, Jacobson KA, Grutter T, Nicke A, Fountain SJ, Kennedy C, Schmalzing G, Jarvis MF, Stojilkovic SS, King BF, Di Virgilio F. (2021) _Br J Pharmacol._ 178(3):489-514. doi:10.1111/bph.15299.
IUPHAR REVIEW CXI: PHARMACOLOGY, SIGNALING, AND PHYSIOLOGY OF METABOTROPIC GLUTAMATE RECEPTORS Gregory KJ, Goudet C (2021) _Pharmacol Rev._ 73: 521-569. IUPHAR REVIEW CX: CLASSIFICATION OF RECEPTORS FOR 5-HYDROXYTRYPTAMINE; PHARMACOLOGY AND FUNCTION Barnes NM, Ahern GP, Becamel C, Bockaert J, Camilleri M, Chaumont-Dubel S, Claeysen S, Cunningham KA, Fone KC, Gershon M, Di Giovanni G, Goodfellow NM, Halberstadt AL, Hartley RM, Hassaine G, Herrick-Davis K, Hovius R, Lacivita E, Lambe EK, Leopoldo M, Levy FO, Lummis SCR, Marin P, Maroteaux L, McCreary AC, Nelson DL, Neumaier JF, Newman-Tancredi A, Nury H, Roberts A, Roth BL, Roumier A, Sanger GJ, Teitler M, Sharp T, Villalón CM, Vogel H, Watts SW, Hoyer D (2021) _Pharmacol Rev._ 73: 310-520.Publication list
PHARMACOLOGY EDUCATION The IUPHAR Pharmacology Education Project is being developed by IUPHAR with support from ASPET as a learning resource for pharmacology and clinical pharmacology.SYNPHARM
SynPharm is a database of ligand-responsive protein sequences, derived from interactions from the Guide to PHARMACOLOGY and using data from the Protein Data Bank.ELIXIR-UK
The IUPHAR/BPS Guide to PHARMACOLOGY is one of the ELIXIR-UK nodeservices.
CORONAVIRUS
Our coronavirus information page has details of pharmcological strategies aimed at mitigating against COVID-19. The page also contains links to other useful resources and publications. Please see our pre-print manuscript on "A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development"
CELEBRATING >20 YEARS OF SERVIER SUPPORT Servier , a mid-size French Pharmaceutical company, has a long history in pharmacology, and has supported NC-IUPHAR for >20 years with unrestricted educational grants which have permitted the Paris meetings and thus progress ofthe database.
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