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Antibodies,
ASSOCIATION BETWEEN PROTON PUMP INHIBITOR USE AND Association Between Proton Pump Inhibitor Use and Cognitive Function in Women Paul Lochhead,1,2 Kaitlin Hagan,3,4 Amit D. Joshi,1,2 Hamed Khalili,1,2 Long H. Nguyen,1,2 Francine Grodstein,3,4 and Andrew T. Chan1,2,4 1Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; 2Division of Gastroenterology, Massachusetts GASTROENTEROLOGY 2021;160:1384 CLINICAL PRACTICE UPDATE The differential diagnosis for patients with suspected ICI enterocolitis is broad. Although no large-scale analyses of the causes of diarrhea in patients on ICIs have been un- GASTROENTEROLOGY 2021;160:1831 CLINICAL PRACTICE UPDATE CLINICAL PRACTICE UPDATE AGA Clinical Practice Update on the Management of Refractory Helicobacter pylori Infection: Expert Review Shailja C. Shah,1,2,3 Prasad G. Iyer,4 and Steven F. Moss5 1Gastroenterology Section, VA San Diego Healthcare System, La Jolla, California; 2VA Tennessee Valley Health System, Nashville, Tennessee; 3Division of Gastroenterology, Hepatology, and Nutrition EFFECTIVENESS OF SARS-COV-2 VACCINATION IN A VETERANS Introduction: The SARS-CoV-2 pandemic is a grave threat to public health with more than 28 million people reported to have been infected and more than half a million deaths in the US alone as of April 2, 2021.1 Inflammatory Bowel Disease (IBD), comprising of Ulcerative Colitis (UC) and Crohn’s Disease (CD), is a chronic inflammatory LOW DOSE IL-2 FOR THE TREATMENT OF MODERATE TO SEVERE A significant proportion of patients with ulcerative colitis (UC) have suboptimal responses to medical therapy. Expansion of regulatory T cells (Tregs), but not conventional T cells (Tcons), through the use of low doses (LD) of the T cell growth factor Interleukin-2 (IL-2, Proleukin®), has been a promising approach in other immune-mediated diseases and pre-clinical humanized UC mouse models. NEW BIOMARKERS FOR CROHN’S DISEASE Case control studies of patients with inflammatory bowel disease (IBD) may facilitate the identification of factors present to a greater extent in those with the disease compared with those without the disease. If these factors are present before disease expression, they might be considered as risk factors. This can lead to further exploration of the biology of the factor in relation to IBD INDUCTION AND LONG-TERM FOLLOW-UP WITH ABX464 FOR MODERATE ABX464 (Abivax, Paris, France) is a novel, first-in-class, orally administered small molecule for treatment of ulcerative colitis (UC). ABX464 interacts with the cap binding complex, allowing specific splicing of anti-inflammatory miR-124 (microRNA-124), leading to a cascade dextran sulfate sodium of modulating proinflammatory cytokines.1 Additionally, ABX464 demonstrated a dual mechanism of ATYPICAL PANCREATITIS One must be constantly alert to the possibilityof pancreatitis with unusual clinical manifestations. We have presented 6 atypical cases of pancreatitis as follows: 1. Pancreatitis presenting as perinephricinflammation and subdiaphragmatic abscess that resulted in left nephrectomy. 2. AGA INSTITUTE GUIDELINES ON HEPATITIS B REACTIVATION (HBVR AGA Institute Guidelines on Hepatitis B Reactivation (HBVr): Clinical Decision Support Tool. American Gastroenterological Association TROUGH CONCENTRATIONS OF INFLIXIMAB GUIDE DOSING FOR Trough Concentrations of Infliximab Guide Dosing for Patients With Inflammatory Bowel Disease Niels Vande Casteele,1 Marc Ferrante,2 Gert Van Assche,2 Vera Ballet,2 Griet Compernolle,1 Kristel Van Steen,3,4 Steven Simoens,5 Paul Rutgeerts,2 Ann Gils,1,§ and Séverine Vermeire2,§ 1Department of Pharmaceutical and Pharmacological Sciences, Laboratory for Therapeutic and DiagnosticAntibodies,
ASSOCIATION BETWEEN PROTON PUMP INHIBITOR USE AND Association Between Proton Pump Inhibitor Use and Cognitive Function in Women Paul Lochhead,1,2 Kaitlin Hagan,3,4 Amit D. Joshi,1,2 Hamed Khalili,1,2 Long H. Nguyen,1,2 Francine Grodstein,3,4 and Andrew T. Chan1,2,4 1Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; 2Division of Gastroenterology, Massachusetts AGA CLINICAL PRACTICE UPDATE ON MEDICAL MANAGEMENT OF Colonic diverticulitis is a painful gastrointestinal disease that recurs unpredictably and can lead to chronic gastrointestinal symptoms. Gastroenterologists commonly care for patients with this disease. The purpose of this Clinical Practice Update is to provide practical and evidence-based advice for management of diverticulitis. We reviewed systematic reviews, meta-analyses, randomized EVIDENCE-BASED MANAGEMENT OF HCC: SYSTEMATIC REVIEW AND Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality with a rapidly changing landscape of treatments. In the past 20 years, numerous randomized controlled trials (RCT) have aimed at improving outcomes across disease stages. We aimed at analyzing the current evidence and identifying potential factors influencing response to therapies. FAECAL MICROBIOTA TRANSPLANTATION INFLUENCES Patients suffering from multiple recurrent Clostridioides difficile infections (rCDI) have a disturbed gut microbiota, which can be restored by faecal microbiota transplantation (FMT). Despite extensive screening, healthy faeces donors may carry bacteria in their intestinal tract that could have long-term health effects, such as potentially procarcinogenic pks+ Escherichia coli. EPIDEMIOLOGY, PATHOPHYSIOLOGY, AND TREATMENT OF DIVERTICULITIS Diverticulitis is a prevalent gastrointestinal disorder that is associated with significant morbidity and health care costs. Approximately 20% of patients with incident diverticulitis have at least 1 recurrence. Complications of diverticulitis, such as abdominal sepsis, are less likely to occur with subsequent events. Several risk factors, many of which are modifiable, have been identified A PILOT STUDY ON AUTOMATIC 3D QUANTIFICATION OF BARRETT’S Barrett’s epithelium measurement using widely accepted Prague C&M classification is highly operator dependent. We propose a novel methodology for measuring this risk score automatically. The method also enables quantification of the area of Barrett’s epithelium (BEA) and islands which was not possible before. Furthermore, it allows 3D reconstruction of the esophageal surface enabling EARLY-AGE ONSET COLORECTAL NEOPLASIA IN AVERAGE RISK Incidence and mortality associated with early age onset colorectal cancer (EAO-CRC) is increasing, prompting professional society recommendations to lower the screening age in average risk individuals. The yield of screening individualsDetails
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