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CHOLESTEROL CODE
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is 7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I waspredicting overall.
CHOLESTEROL CODE
If you know little to nothing about cholesterol->. You can check out my Simple Guide to Cholesterol series.It’s full of illustrations and is written for laypeople. Enjoy! You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time; If you’re wanting to learn more about why cholesterol could be higher, particularly on a ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as FREQUENTLY ASKED QUESTIONS This increase can be anywhere from 50% to 100% or more of their original, pre-low carb diet cholesterol numbers. Typically, a keto/LCHF hyper-responder will have LDL cholesterol (LDL-C) at 170 mg/dl or higher. A subset of hyper-responders called Lean Mass Hyper-responders (HDL >80 mg/dL, Triglycerides 200 mg/dL), have alsoCHOLESTEROL CODE
UPDATE – 10/8/2018: This entire series was written before the podcast was to be released. Many people messaged me this morning about the format change where Peter summarized a rebuttal before the podcast begins in an unusual format change and were quite frustrated about it. LEAN MASS HYPER-RESPONDERS Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile: LDL of 200 mg/dL (5.17 mmol/L) or higher. HDL of 80 mg/dL (2.07 mmol/L) or higher. Triglycerides of 70 mg/dL (0.79 mmol/L) or lower. This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017.REMNANT CHOLESTEROL
It is very simply calculated: you just subtract HDL Cholesterol (HDLc) and LDL Cholesterol (LDLc) from your Total Cholesterol. For example, if your Total Cholesterol were 300, your LDLc 200, and HDLc 80, then you’d have a Remnant Cholesterol (RC) of 20. That’s 300 – 200 – 80 = 20. You can be forgiven if you thought Total Cholesterol was CHOLESTEROL DROP PROTOCOL (“FELDMAN PROTOCOLSEE MORE ONCHOLESTEROLCODE.COM
THE FASTING DISASTER Interesting — instead of being under, I was over on K and Ca. Cholesterol. Of course the big one is the lipid profile. And if you follow me, you already know what I’d predict after fasting for the very first time given the Inversion Pattern –> a record increase inLDL cholesterol.
HIGH TRIGLYCERIDES ON KETO/LCHF High Triglycerides on Keto/LCHF. Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells. The “tri” is for the three fatty acids grouped in each one to a glycerol backbone.CHOLESTEROL CODE
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is 7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I waspredicting overall.
CHOLESTEROL CODE
If you know little to nothing about cholesterol->. You can check out my Simple Guide to Cholesterol series.It’s full of illustrations and is written for laypeople. Enjoy! You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time; If you’re wanting to learn more about why cholesterol could be higher, particularly on a ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as FREQUENTLY ASKED QUESTIONS This increase can be anywhere from 50% to 100% or more of their original, pre-low carb diet cholesterol numbers. Typically, a keto/LCHF hyper-responder will have LDL cholesterol (LDL-C) at 170 mg/dl or higher. A subset of hyper-responders called Lean Mass Hyper-responders (HDL >80 mg/dL, Triglycerides 200 mg/dL), have alsoCHOLESTEROL CODE
UPDATE – 10/8/2018: This entire series was written before the podcast was to be released. Many people messaged me this morning about the format change where Peter summarized a rebuttal before the podcast begins in an unusual format change and were quite frustrated about it. LEAN MASS HYPER-RESPONDERS Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile: LDL of 200 mg/dL (5.17 mmol/L) or higher. HDL of 80 mg/dL (2.07 mmol/L) or higher. Triglycerides of 70 mg/dL (0.79 mmol/L) or lower. This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017.REMNANT CHOLESTEROL
It is very simply calculated: you just subtract HDL Cholesterol (HDLc) and LDL Cholesterol (LDLc) from your Total Cholesterol. For example, if your Total Cholesterol were 300, your LDLc 200, and HDLc 80, then you’d have a Remnant Cholesterol (RC) of 20. That’s 300 – 200 – 80 = 20. You can be forgiven if you thought Total Cholesterol was CHOLESTEROL DROP PROTOCOL (“FELDMAN PROTOCOLSEE MORE ONCHOLESTEROLCODE.COM
THE FASTING DISASTER Interesting — instead of being under, I was over on K and Ca. Cholesterol. Of course the big one is the lipid profile. And if you follow me, you already know what I’d predict after fasting for the very first time given the Inversion Pattern –> a record increase inLDL cholesterol.
HIGH TRIGLYCERIDES ON KETO/LCHF High Triglycerides on Keto/LCHF. Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells. The “tri” is for the three fatty acids grouped in each one to a glycerol backbone. REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions.CHOLESTEROL CODE
Introduction. As our resident Lean Mass Hyper-Responder (LMHR) on the site, I have been an outlier so far with my Lipids.Despite an additional 200g/day of fat, my LDL was effectively unchanged in the Ketofest experiment.I knew exercise was potentially a confounder given Dave’s experiments with distance running, but I had a full training schedule this year leading up to my first marathon LEAN MASS HYPER-RESPONDERS Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile: LDL of 200 mg/dL (5.17 mmol/L) or higher. HDL of 80 mg/dL (2.07 mmol/L) or higher. Triglycerides of 70 mg/dL (0.79 mmol/L) or lower. This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017.CHOLESTEROL CODE
While I know Thanksgiving has passed, I tend to think of the many things to be thankful for near the end of the year. And make no mistake, I have a pretty long list.CHOLESTEROL CODE
Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells.CHOLESTEROL CODE
For quite a while I’ve been wanting to test a theory I’ve had regarding the blood test for oxidized LDL (oxLDL). The test has some research behind it suggesting a correlation with heart disease, which makes sense given this association of oxLDL in the artery walls andatherogenesis.
CHOLESTEROL CODE
Hanging with Vinnie Tortorich before the show. I wanted to post a few things here that were referenced in the podcast. The first being the lipoprotein “boats” that traffic our fat-based energy and play a role in our immune response.CHOLESTEROL CODE
Note from Dave– I’m so happy this work by Craig is finally going up on the site. There was an extraordinary amount of work put into this post, not just in the writing and visuals, but in the meticulous effort he has put forth in mining all the data throughout the site.CHOLESTEROL CODE
It’s barely been 72 hours since launching my Patreon account and inviting support.Honestly, the response has been very humbling. This was in spite of spending 1/3rd of my video ensuring the most important research and education content will always be available here for free — and that I’d rather people save their money if it has any significant financial impact.CHOLESTEROL CODE
To say Low Carb Breckenridge was an outstanding conference would be an understatement. It was probably the single largest turning point for my message so far. I was invited to speak on Sunday at 2:30pm. Once there, I kept tweaking and updating my presentation throughout theconference.
CHOLESTEROL CODE
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is 7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I waspredicting overall.
CHOLESTEROL CODE
If you know little to nothing about cholesterol->. You can check out my Simple Guide to Cholesterol series.It’s full of illustrations and is written for laypeople. Enjoy! You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time; If you’re wanting to learn more about why cholesterol could be higher, particularly on a ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as FREQUENTLY ASKED QUESTIONS This increase can be anywhere from 50% to 100% or more of their original, pre-low carb diet cholesterol numbers. Typically, a keto/LCHF hyper-responder will have LDL cholesterol (LDL-C) at 170 mg/dl or higher. A subset of hyper-responders called Lean Mass Hyper-responders (HDL >80 mg/dL, Triglycerides 200 mg/dL), have alsoCHOLESTEROL CODE
UPDATE – 10/8/2018: This entire series was written before the podcast was to be released. Many people messaged me this morning about the format change where Peter summarized a rebuttal before the podcast begins in an unusual format change and were quite frustrated about it. LEAN MASS HYPER-RESPONDERS Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile: LDL of 200 mg/dL (5.17 mmol/L) or higher. HDL of 80 mg/dL (2.07 mmol/L) or higher. Triglycerides of 70 mg/dL (0.79 mmol/L) or lower. This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017. THE FASTING DISASTER Interesting — instead of being under, I was over on K and Ca. Cholesterol. Of course the big one is the lipid profile. And if you follow me, you already know what I’d predict after fasting for the very first time given the Inversion Pattern –> a record increase inLDL cholesterol.
CHOLESTEROL DROP PROTOCOL (“FELDMAN PROTOCOLSEE MORE ONCHOLESTEROLCODE.COM
HIGH TRIGLYCERIDES ON KETO/LCHF High Triglycerides on Keto/LCHF. Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells. The “tri” is for the three fatty acids grouped in each one to a glycerol backbone.REMNANT CHOLESTEROL
It is very simply calculated: you just subtract HDL Cholesterol (HDLc) and LDL Cholesterol (LDLc) from your Total Cholesterol. For example, if your Total Cholesterol were 300, your LDLc 200, and HDLc 80, then you’d have a Remnant Cholesterol (RC) of 20. That’s 300 – 200 – 80 = 20. You can be forgiven if you thought Total Cholesterol wasCHOLESTEROL CODE
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is 7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I waspredicting overall.
CHOLESTEROL CODE
If you know little to nothing about cholesterol->. You can check out my Simple Guide to Cholesterol series.It’s full of illustrations and is written for laypeople. Enjoy! You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time; If you’re wanting to learn more about why cholesterol could be higher, particularly on a ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as FREQUENTLY ASKED QUESTIONS This increase can be anywhere from 50% to 100% or more of their original, pre-low carb diet cholesterol numbers. Typically, a keto/LCHF hyper-responder will have LDL cholesterol (LDL-C) at 170 mg/dl or higher. A subset of hyper-responders called Lean Mass Hyper-responders (HDL >80 mg/dL, Triglycerides 200 mg/dL), have alsoCHOLESTEROL CODE
UPDATE – 10/8/2018: This entire series was written before the podcast was to be released. Many people messaged me this morning about the format change where Peter summarized a rebuttal before the podcast begins in an unusual format change and were quite frustrated about it. LEAN MASS HYPER-RESPONDERS Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile: LDL of 200 mg/dL (5.17 mmol/L) or higher. HDL of 80 mg/dL (2.07 mmol/L) or higher. Triglycerides of 70 mg/dL (0.79 mmol/L) or lower. This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017. THE FASTING DISASTER Interesting — instead of being under, I was over on K and Ca. Cholesterol. Of course the big one is the lipid profile. And if you follow me, you already know what I’d predict after fasting for the very first time given the Inversion Pattern –> a record increase inLDL cholesterol.
CHOLESTEROL DROP PROTOCOL (“FELDMAN PROTOCOLSEE MORE ONCHOLESTEROLCODE.COM
HIGH TRIGLYCERIDES ON KETO/LCHF High Triglycerides on Keto/LCHF. Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells. The “tri” is for the three fatty acids grouped in each one to a glycerol backbone.REMNANT CHOLESTEROL
It is very simply calculated: you just subtract HDL Cholesterol (HDLc) and LDL Cholesterol (LDLc) from your Total Cholesterol. For example, if your Total Cholesterol were 300, your LDLc 200, and HDLc 80, then you’d have a Remnant Cholesterol (RC) of 20. That’s 300 – 200 – 80 = 20. You can be forgiven if you thought Total Cholesterol was REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions. ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as LEAN MASS HYPER-RESPONDERS Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile: LDL of 200 mg/dL (5.17 mmol/L) or higher. HDL of 80 mg/dL (2.07 mmol/L) or higher. Triglycerides of 70 mg/dL (0.79 mmol/L) or lower. This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017.CHOLESTEROL CODE
Click here to support the project. Greetings everyone, On Friday at Low Carb Houston, I announced the launch of the Citizen Science Foundation, a vehicle for helping us privately raise funds for its central endeavor, the Lean Mass Hyper-responder Measurement Project.. The Lean Mass Hyper-responder (LMHR) phenotype is a strong profile to test the lipid hypothesis, which posits levels ofCHOLESTEROL CODE
Note from Dave– I’m so happy this work by Craig is finally going up on the site. There was an extraordinary amount of work put into this post, not just in the writing and visuals, but in the meticulous effort he has put forth in mining all the data throughout the site.CHOLESTEROL CODE
While I know Thanksgiving has passed, I tend to think of the many things to be thankful for near the end of the year. And make no mistake, I have a pretty long list.CHOLESTEROL CODE
My triglycerides (TG) were exceptionally high. I know this to be unusual because I’ve done many just-woke-up tests from experiments before. In fact, the only time I can recall having TG above 100 after having just awoken, was for three days following the second intervention of the Resistance Training Experiment — even then, that was almost 100 mg/dL lower than this number!CHOLESTEROL CODE
Hanging with Vinnie Tortorich before the show. I wanted to post a few things here that were referenced in the podcast. The first being the lipoprotein “boats” that traffic our fat-based energy and play a role in our immune response.CHOLESTEROL CODE
Here’s a transcript of that portion of the talk (at about 21:54): Now we’ve all heard about the Feldman protocol. So essentially what happens is if you have a very high LDL level on a ketogenic diet, it’s been demonstrated, quite nicely, that if you go on a very high fat diet for about three days and have a blood test at the end of it your LDL levels will significantly drop, some wouldCHOLESTEROL CODE
To say Low Carb Breckenridge was an outstanding conference would be an understatement. It was probably the single largest turning point for my message so far. I was invited to speak on Sunday at 2:30pm. Once there, I kept tweaking and updating my presentation throughout theconference.
CHOLESTEROL CODE
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is 7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I waspredicting overall.
ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as high as 368 mg/dL. I’ve had my LDL-C as low as 98 mg/dL. REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions. HIGH TRIGLYCERIDES ON KETO/LCHF High Triglycerides on Keto/LCHF. Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells. The “tri” is for the three fatty acids grouped in each one to a glycerol backbone. LIPIDS AND VIRAL INFECTIONS In our last post about lipids and the immune system, we focused about how lipoproteins, particularly LDL, can participate in immune responses directly during infection – both by blocking the infection of cells through multiple mechanisms, and by binding to pathogens to neutralize them.In that post, infections were being referenced generally – both viral and bacterial. THE FASTING DISASTER Interesting — instead of being under, I was over on K and Ca. Cholesterol. Of course the big one is the lipid profile. And if you follow me, you already know what I’d predict after fasting for the very first time given the Inversion Pattern –> a record increase inLDL cholesterol.
TALKING CHOLESTEROL, OXIDATION, HYPER-RESPONDERS, AND RISK Talking Cholesterol, Oxidation, Hyper-responders, and Risk with Paul Saladino. By Dave in Cholesterol, Interview, Lean Mass Hyper-responder, Video. Had a great conversation with Paul. Not surprisingly, lots of topics came up with regard to the risk, my current oxLDL vs oxPL experiment, my recent research regarding FH receptors, etc. YouTube IMPACT OF ENDURANCE RUNNING ON CHOLESTEROL Endurance Running Effect on LDL-C. Okay, now let’s get to the graphs. As usual, I present the left and right axis in relative terms so you can see the obvious relationship. Thus, the one of the left starts at the bottom with -10 and goes upward to 490 with the one on the right starting at 120 and going to 400. MY PERSONAL JOURNEY WITH RESPECTFUL DEBATE My Personal Journey with Respectful Debate. If you’ve followed me on social media for long, you’ll note I’m very proactive about engaging in conversations with people of opposing views. I consider this one of the most important tools for learning in my toolbox. This isn’t because a single response tweet or comment can tell you DEBATE/DISCUSSION WITH LAYNE NORTON (BIOLAYNE Hi a Lean Mass Hyper-responder is someone who has HDL of 80+, TG of 70 or below and LDL of 200 or above. So without further information it’s difficult to tell if you fit the profile or not. With that said, we’ve noticed from the data people have reported back to us that results from switching to a ketogenic or low carb diet aren’t typically representative until about 4+ months inCHOLESTEROL CODE
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is 7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I waspredicting overall.
ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as high as 368 mg/dL. I’ve had my LDL-C as low as 98 mg/dL. REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions. HIGH TRIGLYCERIDES ON KETO/LCHF High Triglycerides on Keto/LCHF. Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells. The “tri” is for the three fatty acids grouped in each one to a glycerol backbone. LIPIDS AND VIRAL INFECTIONS In our last post about lipids and the immune system, we focused about how lipoproteins, particularly LDL, can participate in immune responses directly during infection – both by blocking the infection of cells through multiple mechanisms, and by binding to pathogens to neutralize them.In that post, infections were being referenced generally – both viral and bacterial. THE FASTING DISASTER Interesting — instead of being under, I was over on K and Ca. Cholesterol. Of course the big one is the lipid profile. And if you follow me, you already know what I’d predict after fasting for the very first time given the Inversion Pattern –> a record increase inLDL cholesterol.
TALKING CHOLESTEROL, OXIDATION, HYPER-RESPONDERS, AND RISK Talking Cholesterol, Oxidation, Hyper-responders, and Risk with Paul Saladino. By Dave in Cholesterol, Interview, Lean Mass Hyper-responder, Video. Had a great conversation with Paul. Not surprisingly, lots of topics came up with regard to the risk, my current oxLDL vs oxPL experiment, my recent research regarding FH receptors, etc. YouTube IMPACT OF ENDURANCE RUNNING ON CHOLESTEROL Endurance Running Effect on LDL-C. Okay, now let’s get to the graphs. As usual, I present the left and right axis in relative terms so you can see the obvious relationship. Thus, the one of the left starts at the bottom with -10 and goes upward to 490 with the one on the right starting at 120 and going to 400. MY PERSONAL JOURNEY WITH RESPECTFUL DEBATE My Personal Journey with Respectful Debate. If you’ve followed me on social media for long, you’ll note I’m very proactive about engaging in conversations with people of opposing views. I consider this one of the most important tools for learning in my toolbox. This isn’t because a single response tweet or comment can tell you DEBATE/DISCUSSION WITH LAYNE NORTON (BIOLAYNE Hi a Lean Mass Hyper-responder is someone who has HDL of 80+, TG of 70 or below and LDL of 200 or above. So without further information it’s difficult to tell if you fit the profile or not. With that said, we’ve noticed from the data people have reported back to us that results from switching to a ketogenic or low carb diet aren’t typically representative until about 4+ months inCHOLESTEROL CODE
If you know little to nothing about cholesterol->. You can check out my Simple Guide to Cholesterol series.It’s full of illustrations and is written for laypeople. Enjoy! You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time; If you’re wanting to learn more about why cholesterol could be higher, particularly on a REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions. LEAN MASS HYPER-RESPONDERS Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile: LDL of 200 mg/dL (5.17 mmol/L) or higher. HDL of 80 mg/dL (2.07 mmol/L) or higher. Triglycerides of 70 mg/dL (0.79 mmol/L) or lower. This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017.CHOLESTEROL CODE
Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells.CHOLESTEROL CODE
This week, Robb Wolf had Dr. Shawn Baker on his podcast, The Paleo Solution. Baker has been a controversial figure for his embracing a meat-only diet (no plants). Naturally, this has made him a favorite target of vegans, particularly youtubers.What makes him especially interesting is that he’s not just an athlete, but he’s actually setting a number of world records for his age class (overCHOLESTEROL CODE
Hanging with Vinnie Tortorich before the show. I wanted to post a few things here that were referenced in the podcast. The first being the lipoprotein “boats” that traffic our fat-based energy and play a role in our immune response.CHOLESTEROL CODE
A Very Different Path. If you haven’t already, be sure to first read Part 1 of this experiment by Siobhan Huggins.. Originally, Siobhan and I were going to simply do the same protocol at the same time, perhaps something similar to the one I did with my sister two years ago.CHOLESTEROL CODE
My triglycerides (TG) were exceptionally high. I know this to be unusual because I’ve done many just-woke-up tests from experiments before. In fact, the only time I can recall having TG above 100 after having just awoken, was for three days following the second intervention of the Resistance Training Experiment — even then, that was almost 100 mg/dL lower than this number!CHOLESTEROL CODE
The First Hint. As the #LDLBounty continues, and the question of whether high LDL in isolation raises the risk of cardiovascular mortality (or all-cause mortality) in and of itself remains unanswered, there may be a group which may give one even more pause when contemplating the answer. My first hint that things weren’t exactly equal in regards to cholesterol between men and women was wayCHOLESTEROL CODE
As mentioned earlier, I guested on Attia’s podcast.It was a pleasure to meet Peter and his staff and we got to chat briefly before and after the podcast. The recording itself ran to three and a half hours (!) and no, I won’t be revealing much from it.CHOLESTEROL CODE
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is 7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I waspredicting overall.
ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as high as 368 mg/dL. I’ve had my LDL-C as low as 98 mg/dL. REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions. HIGH TRIGLYCERIDES ON KETO/LCHF High Triglycerides on Keto/LCHF. Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells. The “tri” is for the three fatty acids grouped in each one to a glycerol backbone. CHOLESTEROL CODE WORKBOOK 2: THE MYSTERIOUS LIPOPROTEIN(A) On this episode of the Cholesterol Code Workbook, we discuss five papers about the most mysterious lipoprotein: Lipoprotein(a). We discuss its involvement in wound healing, its role as a carrier for oxidized phospholipids, and potential influences on risk for cardiovascular disease. THE FASTING DISASTER Interesting — instead of being under, I was over on K and Ca. Cholesterol. Of course the big one is the lipid profile. And if you follow me, you already know what I’d predict after fasting for the very first time given the Inversion Pattern –> a record increase inLDL cholesterol.
TALKING CHOLESTEROL, OXIDATION, HYPER-RESPONDERS, AND RISK Talking Cholesterol, Oxidation, Hyper-responders, and Risk with Paul Saladino. By Dave in Cholesterol, Interview, Lean Mass Hyper-responder, Video. Had a great conversation with Paul. Not surprisingly, lots of topics came up with regard to the risk, my current oxLDL vs oxPL experiment, my recent research regarding FH receptors, etc. YouTube IMPACT OF ENDURANCE RUNNING ON CHOLESTEROL Endurance Running Effect on LDL-C. Okay, now let’s get to the graphs. As usual, I present the left and right axis in relative terms so you can see the obvious relationship. Thus, the one of the left starts at the bottom with -10 and goes upward to 490 with the one on the right starting at 120 and going to 400.REMNANT CHOLESTEROL
It is very simply calculated: you just subtract HDL Cholesterol (HDLc) and LDL Cholesterol (LDLc) from your Total Cholesterol. For example, if your Total Cholesterol were 300, your LDLc 200, and HDLc 80, then you’d have a Remnant Cholesterol (RC) of 20. That’s 300 – 200 – 80 = 20. You can be forgiven if you thought Total Cholesterol was MY PERSONAL JOURNEY WITH RESPECTFUL DEBATE My Personal Journey with Respectful Debate. If you’ve followed me on social media for long, you’ll note I’m very proactive about engaging in conversations with people of opposing views. I consider this one of the most important tools for learning in my toolbox. This isn’t because a single response tweet or comment can tell youCHOLESTEROL CODE
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is 7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I waspredicting overall.
ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as high as 368 mg/dL. I’ve had my LDL-C as low as 98 mg/dL. REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions. HIGH TRIGLYCERIDES ON KETO/LCHF High Triglycerides on Keto/LCHF. Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells. The “tri” is for the three fatty acids grouped in each one to a glycerol backbone. CHOLESTEROL CODE WORKBOOK 2: THE MYSTERIOUS LIPOPROTEIN(A) On this episode of the Cholesterol Code Workbook, we discuss five papers about the most mysterious lipoprotein: Lipoprotein(a). We discuss its involvement in wound healing, its role as a carrier for oxidized phospholipids, and potential influences on risk for cardiovascular disease. THE FASTING DISASTER Interesting — instead of being under, I was over on K and Ca. Cholesterol. Of course the big one is the lipid profile. And if you follow me, you already know what I’d predict after fasting for the very first time given the Inversion Pattern –> a record increase inLDL cholesterol.
TALKING CHOLESTEROL, OXIDATION, HYPER-RESPONDERS, AND RISK Talking Cholesterol, Oxidation, Hyper-responders, and Risk with Paul Saladino. By Dave in Cholesterol, Interview, Lean Mass Hyper-responder, Video. Had a great conversation with Paul. Not surprisingly, lots of topics came up with regard to the risk, my current oxLDL vs oxPL experiment, my recent research regarding FH receptors, etc. YouTube IMPACT OF ENDURANCE RUNNING ON CHOLESTEROL Endurance Running Effect on LDL-C. Okay, now let’s get to the graphs. As usual, I present the left and right axis in relative terms so you can see the obvious relationship. Thus, the one of the left starts at the bottom with -10 and goes upward to 490 with the one on the right starting at 120 and going to 400.REMNANT CHOLESTEROL
It is very simply calculated: you just subtract HDL Cholesterol (HDLc) and LDL Cholesterol (LDLc) from your Total Cholesterol. For example, if your Total Cholesterol were 300, your LDLc 200, and HDLc 80, then you’d have a Remnant Cholesterol (RC) of 20. That’s 300 – 200 – 80 = 20. You can be forgiven if you thought Total Cholesterol was MY PERSONAL JOURNEY WITH RESPECTFUL DEBATE My Personal Journey with Respectful Debate. If you’ve followed me on social media for long, you’ll note I’m very proactive about engaging in conversations with people of opposing views. I consider this one of the most important tools for learning in my toolbox. This isn’t because a single response tweet or comment can tell youCHOLESTEROL CODE
If you know little to nothing about cholesterol->. You can check out my Simple Guide to Cholesterol series.It’s full of illustrations and is written for laypeople. Enjoy! You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time; If you’re wanting to learn more about why cholesterol could be higher, particularly on a REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions. LEAN MASS HYPER-RESPONDERS Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile: LDL of 200 mg/dL (5.17 mmol/L) or higher. HDL of 80 mg/dL (2.07 mmol/L) or higher. Triglycerides of 70 mg/dL (0.79 mmol/L) or lower. This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017.CHOLESTEROL CODE
Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells.CHOLESTEROL CODE
With this vital survey (5-8m of your time), we’re looking to gather a very large number of entries for our anonymised data pool. We’ll post graphs of the data in future articles and it will allow for strong information on some important decisions ahead.CHOLESTEROL CODE
Hanging with Vinnie Tortorich before the show. I wanted to post a few things here that were referenced in the podcast. The first being the lipoprotein “boats” that traffic our fat-based energy and play a role in our immune response.CHOLESTEROL CODE
While I know Thanksgiving has passed, I tend to think of the many things to be thankful for near the end of the year. And make no mistake, I have a pretty long list.CHOLESTEROL CODE
A Very Different Path. If you haven’t already, be sure to first read Part 1 of this experiment by Siobhan Huggins.. Originally, Siobhan and I were going to simply do the same protocol at the same time, perhaps something similar to the one I did with my sister two years ago.CHOLESTEROL CODE
As mentioned earlier, I guested on Attia’s podcast.It was a pleasure to meet Peter and his staff and we got to chat briefly before and after the podcast. The recording itself ran to three and a half hours (!) and no, I won’t be revealing much from it.CHOLESTEROL CODE
Incredible! LDL-P is nearly cut in half! This was even more impact than I had predicted. While it is true my LDL-P continued to drop into the 5th day (to be covered in an upcoming post), the shift in just 72 hours was really impressive.CHOLESTEROL CODE
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is 7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I waspredicting overall.
CHOLESTEROL CODE
If you know little to nothing about cholesterol->. You can check out my Simple Guide to Cholesterol series.It’s full of illustrations and is written for laypeople. Enjoy! You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time; If you’re wanting to learn more about why cholesterol could be higher, particularly on a ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions. LEAN MASS HYPER-RESPONDERS Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile: LDL of 200 mg/dL (5.17 mmol/L) or higher. HDL of 80 mg/dL (2.07 mmol/L) or higher. Triglycerides of 70 mg/dL (0.79 mmol/L) or lower. This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017. HIGH TRIGLYCERIDES ON KETO/LCHF High Triglycerides on Keto/LCHF. Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells. The “tri” is for the three fatty acids grouped in each one to a glycerol backbone. THE FASTING DISASTER Interesting — instead of being under, I was over on K and Ca. Cholesterol. Of course the big one is the lipid profile. And if you follow me, you already know what I’d predict after fasting for the very first time given the Inversion Pattern –> a record increase inLDL cholesterol.
IMPACT OF ENDURANCE RUNNING ON CHOLESTEROL Endurance Running Effect on LDL-C. Okay, now let’s get to the graphs. As usual, I present the left and right axis in relative terms so you can see the obvious relationship. Thus, the one of the left starts at the bottom with -10 and goes upward to 490 with the one on the right starting at 120 and going to 400.REMNANT CHOLESTEROL
It is very simply calculated: you just subtract HDL Cholesterol (HDLc) and LDL Cholesterol (LDLc) from your Total Cholesterol. For example, if your Total Cholesterol were 300, your LDLc 200, and HDLc 80, then you’d have a Remnant Cholesterol (RC) of 20. That’s 300 – 200 – 80 = 20. You can be forgiven if you thought Total Cholesterol was THOUGHTS ON SHAWN BAKER’S LABS This week, Robb Wolf had Dr. Shawn Baker on his podcast, The Paleo Solution. Baker has been a controversial figure for his embracing a meat-only diet (no plants). Naturally, this has made him a favorite target of vegans, particularly youtubers.What makes him especially interesting is that he’s not just an athlete, but he’s actually setting a number of world records for his age class (overCHOLESTEROL CODE
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is 7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I waspredicting overall.
CHOLESTEROL CODE
If you know little to nothing about cholesterol->. You can check out my Simple Guide to Cholesterol series.It’s full of illustrations and is written for laypeople. Enjoy! You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time; If you’re wanting to learn more about why cholesterol could be higher, particularly on a ABOUT – CHOLESTEROL CODE In the first public presentation of my data, I arranged an experiment where I dropped my LDL-C by 73 mg/dL and LDL-P by 1115 nm/L in just three days. In a recent experiment, I dropped my LDL-C by 104 mg/dL in seven days from 207 to 103. I’ve had my LDL-C as REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions. LEAN MASS HYPER-RESPONDERS Generally speaking, Lean Mass Hyper-responders (LMHRs) have the following lipid profile: LDL of 200 mg/dL (5.17 mmol/L) or higher. HDL of 80 mg/dL (2.07 mmol/L) or higher. Triglycerides of 70 mg/dL (0.79 mmol/L) or lower. This pattern was first discussed in the original Are You a Lean Mass Hyper-responder articles from July of 2017. HIGH TRIGLYCERIDES ON KETO/LCHF High Triglycerides on Keto/LCHF. Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells. The “tri” is for the three fatty acids grouped in each one to a glycerol backbone. THE FASTING DISASTER Interesting — instead of being under, I was over on K and Ca. Cholesterol. Of course the big one is the lipid profile. And if you follow me, you already know what I’d predict after fasting for the very first time given the Inversion Pattern –> a record increase inLDL cholesterol.
IMPACT OF ENDURANCE RUNNING ON CHOLESTEROL Endurance Running Effect on LDL-C. Okay, now let’s get to the graphs. As usual, I present the left and right axis in relative terms so you can see the obvious relationship. Thus, the one of the left starts at the bottom with -10 and goes upward to 490 with the one on the right starting at 120 and going to 400.REMNANT CHOLESTEROL
It is very simply calculated: you just subtract HDL Cholesterol (HDLc) and LDL Cholesterol (LDLc) from your Total Cholesterol. For example, if your Total Cholesterol were 300, your LDLc 200, and HDLc 80, then you’d have a Remnant Cholesterol (RC) of 20. That’s 300 – 200 – 80 = 20. You can be forgiven if you thought Total Cholesterol was THOUGHTS ON SHAWN BAKER’S LABS This week, Robb Wolf had Dr. Shawn Baker on his podcast, The Paleo Solution. Baker has been a controversial figure for his embracing a meat-only diet (no plants). Naturally, this has made him a favorite target of vegans, particularly youtubers.What makes him especially interesting is that he’s not just an athlete, but he’s actually setting a number of world records for his age class (overCHOLESTEROL CODE
If you know little to nothing about cholesterol->. You can check out my Simple Guide to Cholesterol series.It’s full of illustrations and is written for laypeople. Enjoy! You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time; If you’re wanting to learn more about why cholesterol could be higher, particularly on a REPORT – CHOLESTEROL CODE The contributors to CholesterolCode are not doctors, and cannot give medical advice. The information contained on CholesterolCode is for general information purposes only and is not intended to replace a professional diagnosis, nor is it intended to treat, cure, or prevent any medical conditions. LAB TESTS – MEASURING YOUR METABOLIC HEALTH – CHOLESTEROL CODE Glycation is when blood sugars stick to a protein or lipid in your body, causing trouble. HA1c is an approximation of your average blood glucose of the past 3-months. This test helps give a score in your struggle against metabolic syndrome. Amy Berger’s low-carb testing series covers HA1c inCHOLESTEROL CODE
See OxLDL Replication Experiment Design post for further information on setup.. Again, this experiment was executed with the intent replicate the prior OxLDL experiment in April of last year. As such, we have excellent comparison data as well. But of special interest is the “OxPL-apoB” assay offered through Boston Heart Diagnostics. It was a key consideration given my interest in thisCHOLESTEROL CODE
This week, Robb Wolf had Dr. Shawn Baker on his podcast, The Paleo Solution. Baker has been a controversial figure for his embracing a meat-only diet (no plants). Naturally, this has made him a favorite target of vegans, particularly youtubers.What makes him especially interesting is that he’s not just an athlete, but he’s actually setting a number of world records for his age class (overCHOLESTEROL CODE
Triglycerides (TGs) are effectively fat-based energy. And if you’re on a low carb, high fat diet (LCHF), you are likely eating them every day, along with storing them as such in your own fat cells.CHOLESTEROL CODE
While I know Thanksgiving has passed, I tend to think of the many things to be thankful for near the end of the year. And make no mistake, I have a pretty long list.CHOLESTEROL CODE
As mentioned earlier, I guested on Attia’s podcast.It was a pleasure to meet Peter and his staff and we got to chat briefly before and after the podcast. The recording itself ran to three and a half hours (!) and no, I won’t be revealing much from it.CHOLESTEROL CODE
Incredible! LDL-P is nearly cut in half! This was even more impact than I had predicted. While it is true my LDL-P continued to drop into the 5th day (to be covered in an upcoming post), the shift in just 72 hours was really impressive.CHOLESTEROL CODE
Here’s a transcript of that portion of the talk (at about 21:54): Now we’ve all heard about the Feldman protocol. So essentially what happens is if you have a very high LDL level on a ketogenic diet, it’s been demonstrated, quite nicely, that if you go on a very high fat diet for about three days and have a blood test at the end of it your LDL levels will significantly drop, some would* __
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Jan 20
START HERE (PINNED)
* By Dave in Cholesterol, Experiments
, Interview
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, Video
PLEASE CONSIDER SUPPORTING OUR NEWLY LAUNCHED CITIZEN SCIENCE FOUNDATION AND ITS CENTRAL ENDEAVOR, THE LMHR MEASUREMENT PROJECT.
YOUR CONTRIBUTIONS ARE MAKING CITIZEN SCIENCE A REALITY – THANK YOU!Dave’s
presentation to Stanford University * IF YOU KNOW LITTLE TO NOTHING ABOUT CHOLESTEROL-> * You can check out my Simple Guide to Cholesterol series.
It’s full of illustrations and is written for laypeople. Enjoy! * You can enter your cholesterol numbers into our popular Report tool to check them against many risk calculations at the same time * IF YOU’RE WANTING TO LEARN MORE ABOUT _WHY_ CHOLESTEROL COULD BE HIGHER, PARTICULARLY ON A LOW CARB DIET-> * YOU CAN WATCH DAVE’S RECENT PRESENTATION FOR STANFORD UNIVERSITY ON THE LIPID ENERGY MODEL. * You can also check out the Lipid Energy Model posterhere
* You can also check out or Frequently Asked Questions (FAQ) here * IF YOU’RE LOOKING TO BETTER UNDERSTAND THE RISK ASSOCIATED WITH HIGH CHOLESTEROL ON A LOW CARB DIET-> * Watch Dave’s Deep Dive on Cholesterol and Risk presentation for a more optimisticoutlook
* Or you can read The Case for Lower LDL on Low Carb by Spencer Nadolsky for the more pessimistic counterpoint * IF YOU’D LIKE TO UNDERSTAND POSSIBLE BENEFITS OF CHOLESTEROL AND THE IMMUNE SYSTEM, you can read Siobhan’s overview article on thetopic
here or watch her presentation here * IF YOU’D LIKE TO LEARN MORE ABOUT LIPOPROTEIN(A), you can watch Siobhan’s presentation on it here * _LASTLY — YOU CAN ALWAYS JUST ASK US ANYTHING OUR QUESTIONS PAGE _. (Just be aware our site does not constitute medical advice and we always recommend consultingwith your doctor.)
* __ 436 comments
May 26
FOR MEDICAL PROFESSIONALS (PART I): HYPER-RESPONDERS AND THE LIPIDTRIAD
* By Dave in Cholesterol, Citizen Science
Foundation
,
Lean Mass Hyper-responder,
Study , Triglyceride In recent months, there has been a growing focus in Lipidology on the phenomenon of high cholesterol levels for those going on a low carb diet. In particular, there have been recent case series published in the Journal of Clinical Lipidology discussing this specifically. This increased interest is certainly welcome, and we definitely advocate for expanding research on this important topic as it has been a central focus of our work for over five years. It should first be emphasized neither myself (Dave Feldman ) nor my colleague, Siobhan Huggins , are medical professionals and this doesn’t constitute medical advice. Moreover, we frequently make this distinction to those following our work. That said, while much of our research isn’t in a formal setting, we have accumulated a great deal of data and analyses that we’ve found helpful to ourselves and others. And, we’ll soon be partnering with doctors Spencer Nadolsky and Tommy Wood on a coming clinical study that will be testing these high levels of cholesterol and its association development of atherosclerosis. (More on this below)HYPER-RESPONDERS
The term “hyper-responder” has been used within the low carb community for several years, and it generally refers to those who see a substantial increase in their total and LDL cholesterol levels after adopting a low carb, high fat diet. We believe the term was first used by Dr. Thomas Dayspring in relation to this dietary outcome (originally discussed in an article on LecturePad.org, but this site is longer available). THE LOW CARB LIPID TRIAD We believe there is a particular lipid profile of enormous interest that goes beyond simply higher LDL cholesterol (LDL-C) seen in hyper-responders. It’s the combination of high HDL cholesterol (HDL-C) and low triglycerides (TG) alongside it. This is actually much more common in those having adopted a low carb diet who appear in excellent metabolic health. And we believe it’s an extremely important clue in helping to explain why LDL-C is higher in these individuals. We’ll go into this in further detail in the next partof this series.
Studies on those with this “triad” of high LDL-C, high HDL-C, and low TG are limited. But of those studies we’ve found, this profile associates with a low risk of cardiovascular disease overall, though slightly more than its counterpart triad with low LDL-C. In this Framingham Offspring study, we highlight
the odds ratio of those both with LDL-C ≥ 100 and 130 under the “High HDL-C” column (≥ 40 males, ≥ 50 females), and triglycerides < 100. (Colored markings and overlay mine) In this observational cohort study of 2906 men aged 53 to 74 years free of IHD at baseline, we see this
relationship as well. (Colored markings mine) Thus, while these studies are not explicitly on those consuming a low carb diet, that may give us the most insight we can for the time being on what the risk level may be with this particular lipid profile. Conversely, low HDL and high triglycerides are well established in the literature as key components to Atherogenic Dyslipidemiaand Metabolic
Syndrome
overall. These profiles are strongly associated with Coronary Artery Disease and all-cause mortality. LEAN MASS HYPER-RESPONDERS The phenotype “Lean Mass Hyper-responder” (LMHRs) is a subset of these hyper-responders, and are characterized as having an extraordinarily pronounced lipid triad. These were first defined myself in an article on Cholesterol Code in July of 2017.
There are exactly three criteria for LMHRs: * LDL cholesterol of 200 mg/dL or higher * HDL cholesterol of 80 mg/dL or higher * Triglycerides of 70 mg/dL or lower. Figure 1 Individual lipid measures for high-carbohydrate (n=10) and low-carbohydrate (n=10) ultra-endurance athletes. Bars represent mean±1SD. HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol. TC, total cholesterol; TG, triglyceride. *P< 0.05; **P < 0.01; ***P < 0.001. Much of the reason this phenotype was referred to as “Lean Mass” is that many who presented with this pattern were often very lean and/or fit while on a very low carb diet. But this term was strictly observational. We have since observed a few outliers that have been slightly overweight, but none as of yet that have been obese. While counterintuitive, generally the highest levels of total and LDL cholesterol in the low carb community are found almost exclusively in LMHRs. Where it is often observed marginally higher cholesterol is found in those with poor health, LMHRs often presents with very low risk markers across the board, such as low blood pressure, waist-to-hip ratio, inflammatory markers, and HOMA-IR to name a few. There has been speculation of a genetic component that might result in these substantially higher levels, such as a polygenetic FH or ApoE4. But shared data among this community has continued to show a wide genetic variability with no predominant genetic variants yet identified. Moreover, existing studies from Volek and Phinney on low carb athletes show a near ubiquity in this pattern as well. (At right, see Figure 1 from thestudy)
A POSSIBLE MODEL TO HELP EXPLAIN We believe higher total and LDL cholesterol levels in those going on a low carb diet can be in part explained by greater synthesis, secretion, and turnover of triglyceride-rich VLDL, thus leading to a higher resulting quantity of LDL particles, particularly with LMHRs. This “Lipid Energy Model” is being developed by our team and we hope to have it published in the future. For a brief overview, you can visit our Lipid Energy Model poster , or watch my presentation toStanford
.
NEW ATTENTION BY THE NATIONAL LIPID ASSOCIATION Recently, the Journal of Clinical Lipidology has published case series on this phenomenon, Keto diets, not for everyone and Extreme elevations of low-density lipoprotein cholesterol with very low carbohydrate, high fat diets.
These data include some patients with concerning outcomes, such as the case of hypertriglyceridemia (high TG, rather than low) and xanthomadevelopment.
To be sure, we’re not aware of any in the series published that meet the criteria of Lean Mass Hyper-responders, but this term is mentioned prominently in these articles and may result in some confusion that the phenotype can apply to everyone observing increased LDL cholesterol from diet without regard to HDL and triglycerides. Again, this phenotype is defined by all three all three cut points (per above), not LDL-C alone. Moreover, we would likewise agree that low HDL-C and high TG (characteristic of Atherogenic Dyslipidemia) is a concerning profile whether one has high or low LDL-C. As our site was mentioned in the initial case series, we submitted a Letter to the Editor for our response. However, our letter was rejected. We’ve since published it as an Open Letter to the Editor which you can read here.
We’ll continue to seek productive engagement with the National Lipid Association as we appreciate their exceptional ability to help move this research forward. To speak plainly, if you’re a Lipidologist reading this now and you’ve been instinctively skeptical of our work, it’s entirely understandable given the high saturation of poorly researched advice given to patients found on the internet. Winning trust for our unique circumstances may take time for many in this important field, but we’ll continue to do our best in accomplishing it. _Please be aware we’re always interested in discussing this crucial topic with professionals, sharing our community data, and helping in any way we can to further advance research in this important (and in our opinion, understudied) phenomenon._ OUR COMING CLINICAL TRIAL ON LMHRS A year and a half ago we founded a fully qualified 501(c)(3) public charity, the Citizen Science Foundation . It was started in large part because we wanted to raise money for clinical trials to take this important data to the next level. And I’m pleased to say we’ve successfully crowdfunded a study that is now in IRB. This study will enroll 100 Lean Mass Hyper-responders and capture high resolution CTangiograms on each
,
both at the beginning and end of the trial one year later. With these comparison scans, we’ll have strong data on progression of plaque volume to better understand the true risk level for this phenotype. We’ll have much more to share on this coming study once we’ve reached approval from the IRB.* __ 12 comments
May 13
HOW TO LOWER YOUR LDL CHOLESTEROL WHEN LOW CARB (IF THAT’S YOURTHING)
* By Dave in Cholesteroladvice._
> 2/ First, you should know that I believe the reason for this higher > LDL when metabolically healthy is generally due to being powered by > fat, which "ride shares" with cholesterol inside these "boats" > called lipoproteins. You can find out more at > https://t.co/3DWtQjmx9b > — Dave Feldman (@DaveKeto) November 23, 2019>
> 4/ This isn't say it's a perfect, linear shift. There seems to be a > kind of "tipping point" for many (including myself) at around 100g > of carbs/day*. As in, if I swap out fat and in carbs, I'll see a > substantial drop in my LDL. I showed this 2 years ago: > https://t.co/lTJXngkytA > — Dave Feldman (@DaveKeto) November 23, 2019>
> 6/ So yes, my most common tip is:>
> <1> Simply reduce fat calories to bring up carb calories. Swap,> don't add.
> — Dave Feldman (@DaveKeto) November 23, 2019>
> 8/ This one is a little more controversial to me, but is in my > second tier list:>
> <3> Reduce saturated fat in favor of mono or polyunsaturated fats> (M/PUFAs).
>
> I'm conflicted because I want to confirm the mechanism behind the > lower LDL is this context is proper. > — Dave Feldman (@DaveKeto) November 23, 2019>
> 10/ In short, I wonder if there's lower LDL total due in large part > to more of them becoming oxidized and being cleared by scavenger > receptors. That's hard to test for, but I have an experiment I may > be doing soon to help find out. > — Dave Feldman (@DaveKeto) November 23, 2019>
> 12/ <5> Gain more fat mass.>
> No, I'm not kidding. Again, this fits the energy model. If you have > more fat mass vs lean mass, there's less need to traffic fatty acids > globally as target tissues have more available locally (or least, > this is my model hypothesis). > — Dave Feldman (@DaveKeto) November 23, 2019>
> 14/ Naturally, there's also discussion of getting your LDL down > through use of a cholesterol-lowering medication, like a statin. > That topic is between you and your doctor. > — Dave Feldman (@DaveKeto) November 23, 2019>
* __ 5 comments
May 02
UPDATES A MANY
* By Dave in CitizenScience Foundation
,
Own Your Labs
This site has been uncharacteristically lacking in posts the last month and a half, mainly due to a large number developments behind the scenes. Here we’ll be providing a summary of what’s beenhappening:
NEW HEIGHTS FOR OWN YOUR LABS OwnYourLabs.com has been experiencing explosive growth! Since our update and announcementin the last
CC post before this one, we’ve seen OYL orders climb substantially. * This was in large part due to our new video and website overhaul. We’re actually quite pleased with the functional updates especially, as we wanted better searching and selecting compared to our original version. * While we’re quite ecstatic for the extraordinary increase, it has certainly required a bit more bandwidth on our part, particularly for Siobhan, who heads up operations for OYL. This now has her working significantly longer than she was before and thus we’re doing some back office reshuffling on resources to make OYL a much more central role to her responsibilities. LEAN MASS HYPER-RESPONDER STUDY IRB Myself, I’m still very much engaged in working toward completing the IRB process for the LMHRstudy.
I’ll concede, it’s some of the most intensive collaboration and detail deliberation I’ve experienced in a long time. Quite a bit of work is being injected in getting the foundation of this studyproperly set forth.
* Many, many rules. While I can’t discuss these things openly until the IRB is approved, I’ll just say there are a number of different expected procedures and processes in both setup and execution of the study that certainly exceeded my original expectations. * And the documents… to say we’ve had many documents to write and revise (and revise again, and again) would be an understatement. There’s just a lot of work that is required in getting this set forits launch.
All that said, I feel quite blessed to have such a strong team to work with in making this happen. Many thanks to Spencer Nadolsky, Tommy Wood, and our partner center (which we hope to announce soon). SIOBHAN AND LIPEDEMA One recent and personal development is the possibility Siobhan may be diagnosed with Lipedema. This hasn’t been a confirmed diagnosis yet, but she’ll be seeing a specialist this coming week to find out withgreater certainty.
> Whelp, I pretty much just got diagnosed with lipedema. Follow-up in > person next month to 100% confirm, but as it stands diagnosing > doctor said "I am almost certain you have it based off of the > information we have". > — P L U © © (@siobhan_huggins) March 3,> 2021
>
The origin of this being a possibility was actually due to her recent #EpicFast experiment . In posting pictures at the end of the experiment, many familiar with Lipedema reached out to her on the topic given her weight loss distribution was very characteristic of the condition. Unsurprisingly, Siobhan has ramped up her research for this topic and has already begun making headway on better understanding the condition. To be sure, she starts off with several advantages given her background already in lipids, inflammation, and of course, her extensive wealth of prior bloodwork throughout her metabolic transformation. Many (like myself) are predicting bring a lot of new innovation to understanding this important and prominent disease. PRESENTATIONS, FOR LIMITED ENGAGEMENT ONLY I decided early in the year to keep presentations at a minimum. I had already turned down a few offers simply because I had too much on my plate with the IRB. But I went ahead and did four over the last two weekends. They all had a few subtle differences, but shared much of the same material. I’ll concede this was a bit more exhausting than I was expecting given the existing work load, but it was nice to unload some of our latest advancements for the Lipid Energy Model.
The videos won’t be posted for a while, but we’ll add them to an article here when they are.* __ 8 comments
Mar 11
OWN YOUR LABS HAS ARRIVED * By Dave in Cholesterol, Citizen Science
Foundation
,
Experiments , Video
For almost a year now Own Your Labs (OYL) has been in a kind of “Soft Launch”. It originated from our efforts to gather anonymized data such as through our#BloodTestingDrive
at
several conferences. Put simply, we’ve sought to (1) get people easier access to bloodwork, and (2) promote greater open science by putting together a publicly archived, yet anonymized set of advanced bloodwork and demographic data. AFFORDABLE PRIVATE LABS = INDEPENDENCE I know this is going to sound like “marketing speak”, but I’m quite serious when I say this – we want everyone who wants to order their labs privately to have the freedom to do so. Which means helping people find the labs they are looking for as affordably as possible, which means keeping our profit margins low AND encouraging comparison shopping. Yes, we even list _our favorite competitors_ on our home page given current recommendation and experience in the community (which I’ll list here as well: Direct Labs, Ulta Lab Tests
, Walk-In Lab
)
A very large number of people have told us over the years that they’d love to get their bloodwork privately instead of waiting for every time it was setup through their doctor’s office. Often they’re interested in the same tests we are (like fasting Insulin, C-Reactive Protein (CRP), or NMR Lipoprofile) that simply aren’t ordered at all by many medical professionals. And while we’d always encourage everyone to take this data back to their doctor, we agree they should have the freedom to get it in the first place. Because of how many tests Siobhan and I get on a regular basis (“power users”) and a bit of negotiating behind the scenes, we have an in of sorts with LabCorp which is how we got this pricing. Moreover, as we build on volume of tests with others through, this will give us stronger negotiating with LabCorp in the future to potentially get better pricing. So in short, yes, our prices are pretty great. But again, that isn’t the real reason we started OYL… GIVE EVERYONE THE OPTION FOR CITIZEN SCIENCE The second (and really, biggest) reason we started OYL was to give everyone the option to contribute their data anonymously. We want to build a large, publicly accessible dataset available to formal and citizen researchers alike. If so many of us are getting these advanced tests on our own, why not share it with the community along with some basic demographic data? This will be especially useful for the low carb demographic given how little open data is available for thisgroup.
So we set it up OYL to make this its central theme. You can either (1) use our service as you would any other online, or (2) submit your data to get a “Citizen Scientist Discount” of 10% off the order. While we had no idea just how many would opt for this choice, I’m pleased to say it’s about 4 out of every 5 who have used OYL todate!
We don’t yet have the anonymized data pool posted as we want to collect a high quantity of submissions to even further anonymize it for those participating. But we will likely meet that threshold in the coming months and launch it here at CC. NOW READY FOR PRIME TIME When we launched OwnYourLabs.com last year it was a simple cart system in a WordPress site. It has been growing ever since, which is great. However, it had a number of things we wanted to improve on. The number of tests listed were limited to 10 a page, it couldn’t sort alphabetically, and the consent to submit anonymized data required a tricky use of a special coupon code tied to our Terms of Service. As of yesterday that’s all history. Now OYL is far more intuitive and easy to use. Tests are now in an infinite scrolling list with a real time search. Sorting can be done either in the drop down or by the column you prefer such as the name or price. Best of all, we have a new consent checkbox that both opens the demographic form and applies a 10% discount all in the same click.FINAL THOUGHTS
While both Siobhan and myself are partners in OYL, it’s been much more a labor of love than a Big Business Venture. Currently we forward all proceeds toward the Citizen Science Foundation . That said, it’s popularity is taking up more and more of our time, and this refresh might be taking that to the next level. I certainly welcome the challenge of greater and greater volume to OYL to build this data pool (CSDA) and to help take us take this chapter of Citizen Science to the next level. I’m excited to see the many different analyses it will inspire from both formal and citizenresearchers.
* __ 19 comments
Feb 22
PRELIMINARY DATA ON OXIDIZED PHOSPHOLIPID RESULTS * By Dave in Cholesterol, Experiments
It’s been pretty darn busy these days as we’ve had a lot going onwith the LMHR Study
,
platform development for OwnYourLabs.com , and some recent work on the Lipid Energy Model paper. Now most of my data has come back for the Eating Window Experiment, but I haven’t had the time to do a full write up. That said, I will at least give the preview on my OxPL-apoB data and why I find it so exciting. WHAT IS THE OXPL-APOB ASSAY? This description I’m taking directly from the Boston HeartDiagnostics
website, which is also where I get the assay: > Oxidized phospholipids are found on all apoB-containing > lipoproteins, namely, LDL, VLDL, and especially Lp(a). When taken up > by the artery wall, oxidized lipoproteins accelerate > atherosclerosis, thereby, increasing the risk of myocardial > infarctions, strokes, and calcific aortic valve stenosis. Oxidized > phospholipids are highly pro-inflammatory and contribute to many > diseases of aging. Clinicians can use OxPL-apoB levels to reclassify > patients into higher or lower risk categories allowing better > personalized care. (For the remainder of this article, I’ll just refer to OxPL-ApoB assimply “OxPL”)
To be sure, I have a complex opinion regarding the elements described above and how this plays into the larger topic of the immune response. That said, I definitely do think this assay has enormous value and have been literally talking about this for years before it was evenavailable.
Even as long ago as the fall of 2018 I was speculating on this comparative value… > … To simplify a bit, would you rather have 1000 LDLp with 1 > oxidized phospholipid on their hull, or 100 LDLp with 10 oxidized > phospholipids on their hull? If an oxLDL doesn't pick up > quantitative differences per-particle, then it seems the 1000 LDLp > *appears* worse. > — Dave Feldman (@DaveKeto) August 23, 2018>
If you’re a bit lost right now, don’t worry, you don’t need to know the biochemistry on this. The big takeaway is that I’ve long waited for this metric as I’ve believed all along it would (1) provide very powerful data on cardiovascular disease risk (and lots of data certainly suggests this), and (2) that in spite of low carb hyper-responders having very high LDL, _I’ve long hypothesized their OxPL values would be generally low._ This is an important metric to determine given OxPL loosely correlates with ApoB in typical diet populations, thus I’ve been speculating something quite contrary to the existing data I’ve been able to find in the research to date.OXPL-APOB AND RISK
One phenomenal scientist who has done incredible work in the field on this is Sam Tsimikas . He has conducted many trials and closely tracked OxPL levels in both humans and animals across many different study designs. I became much more aware of his work a couple years ago and even foundthis older tweet
with regard
to one of my favorite graphs: Figure 2 – DOI: 10.1038/s41586-018-0198-8 The above graph is taken from this study (Tsimikas et al) and has Lp-PLA2 on one axis and the ratio of OxPL over apoB. The OxPL/apoB ratio is something I’m particularly interested in, and its association with cardiovascular risk is unsurprising, but more on thatin a later post.
Since gaining access to the OxPL assay at Boston Heart Diagnostics, I’ve used it a total of seven times over two experiments, the OxLDL Replication Experiment and this recent Eating Window Experiment.
Here are my OxPL, ApoB, and Lp-PLA numbers for all phases: The reference range for the OxPL-ApoB assay is <5.0, 5.0-7.5, and >7.5 nmol/L for “Low”, “Borderline”, and “Increased Risk”, respectively. All my metrics to date have been under 5.0 thus far, but this is what I was predicting overall. Interestingly, there is a clear difference between each experiment within this lower range (2.8-3.8 with the Replication Experiment, and 0.9-1.4 with the Eating WindowExperiment).
The OxPL-ApoB/ApoB ratio is extremely low at a range of 0.007-0.021 across all tests. And for what it’s worth, I suspect this will prove common among those with the Low Carb Lipid Triad, particularly Lean Mass Hyper-responders . But only wider data collection will help confirm/disconfirm if this will be thecase.
FINAL THOUGHTS
Again, this is preliminary, but certainly exciting. I’ve waited a long time to test this assay repeatedly, and I’m happy to see it falling in line with my general expectation given this context. There’s still plenty more variety to look forward to, both in my own experiments and the reported values of others. Of course, I suspect this confirms a generally lower risk assessment given existing research in this area, _but we can’t say for sure either way_. Hence the importance of the LMHR Study as well as regular case data coming in from the LMHR community.* __ 11 comments
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