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MEDIACDX-0159
Celldex is developing monoclonal and bispecific antibodies that address devastating diseases for which available treatments are inadequate. Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directly effect critical pathways to improve the lives of patients withinflammatory
PIPELINE | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline includes immunotherapies and other targeted biologics derived from a broad set of complementary technologies which have the ability to engage the human immune system and/or directly inhibit tumors to treat specific types of cancer or other diseases. CDX-527 | PIPELINE | CELLDEX THERAPEUTICS CDX-527 is the first candidate from Celldex’s bispecific antibody platform. It uses Celldex’s proprietary highly active anti-PD-L1 and CD27 human antibodies to couple CD27 costimulation with blockade of the PD-L1/PD-1 pathway to help prime and activate anti-tumor T cell responses through CD27 costimulation, while preventing PD-1 inhibitory signals that subvert the immune response. CAREERS | ABOUT | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline includes immunotherapies and other targeted biologics derived from a broad set of complementary technologies which have the ability to engage the human immune system and/or directly inhibit tumors to treat specific types of cancer or other diseases. CDX-1140 | PIPELINE | CELLDEX THERAPEUTICS CDX-1140 – A Differentiated CD40 Agonist Antibody. CDX-1140 is a fully human antibody targeted to CD40, a key activator of immune response which is found on dendritic cells, macrophages and B cells and is also expressed on many cancer cells. Potent CD40 agonist antibodies have shown encouraging results in early clinical studies;however
CDX-301 | PIPELINE | CELLDEX THERAPEUTICS CDX-301 is soluble, recombinant human FMS-like tyrosine kinase-3 ligand (Flt3L) that acts by uniquely binding FMS-like tyrosine kinase-3 (Flt3, CD135), which is expressed on hematopoietic stem cells (HSC), early progenitor cells, immature thymocytes, and steady state dendritic cells, resulting in the proliferation, differentiation, development and mobilization of these cells in the bone marrow CELLDEX THERAPEUTICS INITIATES PHASE 1B STUDY OF CDX-0159 HAMPTON, N.J., Oct. 13, 2020 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (Nasdaq:CLDX) announced today that enrollment has opened and the first patient has been dosed in its randomized, double-blind Phase 1b study of CDX-0159 in patients with chronic spontaneous urticaria (CSU). CDX-0159 is a humanized monoclonal antibody developed by Celldex that binds the KIT CDX-0159 | PIPELINE | CELLDEX THERAPEUTICS CDX-0159 – A Potent KIT Inhibitor. CDX-0159 is a humanized monoclonal antibody that specifically binds the receptor tyrosine kinase KIT with high specificity and potently inhibits its activity. KIT is expressed in a variety of cells, including mast cells, which mediate inflammatory responses such as hypersensitivity and allergicreactions.
SIMULTANEOUS DE-REPRESSION OF INNATE AND ADAPTIVE IMMUNE Simultaneous De-repression of Innate and Adaptive Immune Responses Through Dual Targeting of ILT4 and PD-(L)1 with Bispecific An tibodies. 1. Laura Vitale, PHASE 1 STUDY OF THE CD40 AGONIST MONOCLONAL ANTIBODY (MAB Phase 1 study of the CD40 agonist monoclonal antibody (mAb) CDX-1140 alone and in combination with CDX -301 (rhFLT3L) in patients withadvanced cancers
CELLDEX THERAPEUTICSABOUTPIPELINESCIENCECLINICAL TRIALSINVESTORS &MEDIACDX-0159
Celldex is developing monoclonal and bispecific antibodies that address devastating diseases for which available treatments are inadequate. Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directly effect critical pathways to improve the lives of patients withinflammatory
PIPELINE | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline includes immunotherapies and other targeted biologics derived from a broad set of complementary technologies which have the ability to engage the human immune system and/or directly inhibit tumors to treat specific types of cancer or other diseases. CDX-527 | PIPELINE | CELLDEX THERAPEUTICS CDX-527 is the first candidate from Celldex’s bispecific antibody platform. It uses Celldex’s proprietary highly active anti-PD-L1 and CD27 human antibodies to couple CD27 costimulation with blockade of the PD-L1/PD-1 pathway to help prime and activate anti-tumor T cell responses through CD27 costimulation, while preventing PD-1 inhibitory signals that subvert the immune response. CAREERS | ABOUT | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline includes immunotherapies and other targeted biologics derived from a broad set of complementary technologies which have the ability to engage the human immune system and/or directly inhibit tumors to treat specific types of cancer or other diseases. CDX-1140 | PIPELINE | CELLDEX THERAPEUTICS CDX-1140 – A Differentiated CD40 Agonist Antibody. CDX-1140 is a fully human antibody targeted to CD40, a key activator of immune response which is found on dendritic cells, macrophages and B cells and is also expressed on many cancer cells. Potent CD40 agonist antibodies have shown encouraging results in early clinical studies;however
CDX-301 | PIPELINE | CELLDEX THERAPEUTICS CDX-301 is soluble, recombinant human FMS-like tyrosine kinase-3 ligand (Flt3L) that acts by uniquely binding FMS-like tyrosine kinase-3 (Flt3, CD135), which is expressed on hematopoietic stem cells (HSC), early progenitor cells, immature thymocytes, and steady state dendritic cells, resulting in the proliferation, differentiation, development and mobilization of these cells in the bone marrow CELLDEX THERAPEUTICS INITIATES PHASE 1B STUDY OF CDX-0159 HAMPTON, N.J., Oct. 13, 2020 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (Nasdaq:CLDX) announced today that enrollment has opened and the first patient has been dosed in its randomized, double-blind Phase 1b study of CDX-0159 in patients with chronic spontaneous urticaria (CSU). CDX-0159 is a humanized monoclonal antibody developed by Celldex that binds the KIT CDX-0159 | PIPELINE | CELLDEX THERAPEUTICS CDX-0159 – A Potent KIT Inhibitor. CDX-0159 is a humanized monoclonal antibody that specifically binds the receptor tyrosine kinase KIT with high specificity and potently inhibits its activity. KIT is expressed in a variety of cells, including mast cells, which mediate inflammatory responses such as hypersensitivity and allergicreactions.
SIMULTANEOUS DE-REPRESSION OF INNATE AND ADAPTIVE IMMUNE Simultaneous De-repression of Innate and Adaptive Immune Responses Through Dual Targeting of ILT4 and PD-(L)1 with Bispecific An tibodies. 1. Laura Vitale, PHASE 1 STUDY OF THE CD40 AGONIST MONOCLONAL ANTIBODY (MAB Phase 1 study of the CD40 agonist monoclonal antibody (mAb) CDX-1140 alone and in combination with CDX -301 (rhFLT3L) in patients withadvanced cancers
INVESTOR RELATIONS
Investor Relations. Celldex is a clinical stage biotechnology company dedicated to developing monoclonal and bispecific antibodies that address devastating diseases for which available treatments are inadequate. Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directlyaffect
LOCATIONS | ABOUT | CELLDEX THERAPEUTICS 53 Frontage Road, Suite 220. Hampton, NJ 08827. T: (908) 454-7120; F: (908) 454-1911. From the East. Take Route 78 West to exit 12. Take a left at the end of the off-ramp. Take a left at the first traffic light onto Perryville Road. Take a right at the first traffic light onto Frontage road and proceed ~ 0.5 miles. CDX-301 | PIPELINE | CELLDEX THERAPEUTICS CDX-301 is soluble, recombinant human FMS-like tyrosine kinase-3 ligand (Flt3L) that acts by uniquely binding FMS-like tyrosine kinase-3 (Flt3, CD135), which is expressed on hematopoietic stem cells (HSC), early progenitor cells, immature thymocytes, and steady state dendritic cells, resulting in the proliferation, differentiation, development and mobilization of these cells in the bone marrowSTOCK INFORMATION
Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline is built from a proprietary portfolio of antibodies and immunomodulators used alone and in strategic combinations to create novel, disease-specific therapies that induce, enhance or suppress the body's immune response. CONTACT US | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline is built from a proprietary portfolio of antibodies and immunomodulators used alone and in strategic combinations to create novel, disease-specific therapies that induce, enhance or suppress the body's immune response. SIMULTANEOUS DE-REPRESSION OF INNATE AND ADAPTIVE IMMUNE Simultaneous De-repression of Innate and Adaptive Immune Responses Through Dual Targeting of ILT4 and PD-(L)1 with Bispecific An tibodies. 1. Laura Vitale, VARLILUMAB | PIPELINE | CELLDEX THERAPEUTICS Varlilumab is a fully human monoclonal antibody (mAb) that targets CD27, a critical molecule in the activation pathway of lymphocytes. Like CD40, CD27 can be effectively manipulated with activating antibodies to induce potent anti-tumor responses, and may result in less toxicities due to its restricted expression and regulation. BACKGROUND RESULTS BASELINE PATIENT CHARACTERISTICS w) Patients (n) Safety run -in 0.72 4. 5: Dose Expansion pending Total 9. Monotherapy (Part 1) CDX-1140 + CDX-301 (Part 2) CDX-1140 + Pembro. (Part 3) Data highlighted in poster CELLDEX THERAPEUTICS ANNOUNCES REVERSE STOCK SPLIT HAMPTON, N.J., Feb. 08, 2019 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (NASDAQ:CLDX) (“Celldex” or the “Company”) today announced that its Board of Directors has approved a one-for-fifteen reverse stock split of its common stock that became effective today upon the filing with the Secretary of the State of Delaware a Certificate of Amendment to its Certificate of Incorporation. CDX-1140, A NOVEL AGONIST CD40 ANTIBODY WITH POTENT ANTI Title: CDX-1140, A Novel Agonist CD40 Antibody with Potent Anti-lymphoma Activity Created Date: 12/3/2016 8:40:19 PM CELLDEX THERAPEUTICSABOUTPIPELINESCIENCECLINICAL TRIALSINVESTORS &MEDIACDX-0159
Celldex is developing monoclonal and bispecific antibodies that address devastating diseases for which available treatments are inadequate. Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directly effect critical pathways to improve the lives of patients withinflammatory
PIPELINE | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline includes immunotherapies and other targeted biologics derived from a broad set of complementary technologies which have the ability to engage the human immune system and/or directly inhibit tumors to treat specific types of cancer or other diseases. CDX-527 | PIPELINE | CELLDEX THERAPEUTICS CDX-527 is the first candidate from Celldex’s bispecific antibody platform. It uses Celldex’s proprietary highly active anti-PD-L1 and CD27 human antibodies to couple CD27 costimulation with blockade of the PD-L1/PD-1 pathway to help prime and activate anti-tumor T cell responses through CD27 costimulation, while preventing PD-1 inhibitory signals that subvert the immune response. CDX-1140 | PIPELINE | CELLDEX THERAPEUTICS CDX-1140 – A Differentiated CD40 Agonist Antibody. CDX-1140 is a fully human antibody targeted to CD40, a key activator of immune response which is found on dendritic cells, macrophages and B cells and is also expressed on many cancer cells. Potent CD40 agonist antibodies have shown encouraging results in early clinical studies;however
CELLDEX THERAPEUTICS INITIATES PHASE 1B STUDY OF CDX-0159 HAMPTON, N.J., Oct. 13, 2020 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (Nasdaq:CLDX) announced today that enrollment has opened and the first patient has been dosed in its randomized, double-blind Phase 1b study of CDX-0159 in patients with chronic spontaneous urticaria (CSU). CDX-0159 is a humanized monoclonal antibody developed by Celldex that binds the KIT CDX-301 | PIPELINE | CELLDEX THERAPEUTICS CDX-301 is soluble, recombinant human FMS-like tyrosine kinase-3 ligand (Flt3L) that acts by uniquely binding FMS-like tyrosine kinase-3 (Flt3, CD135), which is expressed on hematopoietic stem cells (HSC), early progenitor cells, immature thymocytes, and steady state dendritic cells, resulting in the proliferation, differentiation, development and mobilization of these cells in the bone marrow CDX-0159 | PIPELINE | CELLDEX THERAPEUTICS CDX-0159 – A Potent KIT Inhibitor. CDX-0159 is a humanized monoclonal antibody that specifically binds the receptor tyrosine kinase KIT with high specificity and potently inhibits its activity. KIT is expressed in a variety of cells, including mast cells, which mediate inflammatory responses such as hypersensitivity and allergicreactions.
SIMULTANEOUS DE-REPRESSION OF INNATE AND ADAPTIVE IMMUNE Simultaneous De-repression of Innate and Adaptive Immune Responses Through Dual Targeting of ILT4 and PD-(L)1 with Bispecific An tibodies. 1. Laura Vitale, AN AXL-TARGETING MONOCLONAL ANTIBODY THAT INHIBITS AXL An Axl-targeting Monoclonal Antibody that Inhibits Axl Activity and Potently Stimulates the Innate Immune Response Diego Alvarado 1, Laura Vitale 2, Mike Murphy , Thomas O’Neill, Edward Natoli1, Jay Lillquist1, Linda Crew1, Anna Wasiuk 2, Jeff Weidlick , Crystal Sisson , Jenifer Widger2, Laura Mills-Chen2, Andrea Crocker , Colleen Patterson , James Boyer 3, Eric Forsberg , April R. Baronas 3 PHASE 1 STUDY OF THE CD40 AGONIST MONOCLONAL ANTIBODY (MAB Phase 1 study of the CD40 agonist monoclonal antibody (mAb) CDX-1140 alone and in combination with CDX -301 (rhFLT3L) in patients withadvanced cancers
CELLDEX THERAPEUTICSABOUTPIPELINESCIENCECLINICAL TRIALSINVESTORS &MEDIACDX-0159
Celldex is developing monoclonal and bispecific antibodies that address devastating diseases for which available treatments are inadequate. Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directly effect critical pathways to improve the lives of patients withinflammatory
PIPELINE | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline includes immunotherapies and other targeted biologics derived from a broad set of complementary technologies which have the ability to engage the human immune system and/or directly inhibit tumors to treat specific types of cancer or other diseases. CDX-527 | PIPELINE | CELLDEX THERAPEUTICS CDX-527 is the first candidate from Celldex’s bispecific antibody platform. It uses Celldex’s proprietary highly active anti-PD-L1 and CD27 human antibodies to couple CD27 costimulation with blockade of the PD-L1/PD-1 pathway to help prime and activate anti-tumor T cell responses through CD27 costimulation, while preventing PD-1 inhibitory signals that subvert the immune response. CDX-1140 | PIPELINE | CELLDEX THERAPEUTICS CDX-1140 – A Differentiated CD40 Agonist Antibody. CDX-1140 is a fully human antibody targeted to CD40, a key activator of immune response which is found on dendritic cells, macrophages and B cells and is also expressed on many cancer cells. Potent CD40 agonist antibodies have shown encouraging results in early clinical studies;however
CELLDEX THERAPEUTICS INITIATES PHASE 1B STUDY OF CDX-0159 HAMPTON, N.J., Oct. 13, 2020 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (Nasdaq:CLDX) announced today that enrollment has opened and the first patient has been dosed in its randomized, double-blind Phase 1b study of CDX-0159 in patients with chronic spontaneous urticaria (CSU). CDX-0159 is a humanized monoclonal antibody developed by Celldex that binds the KIT CDX-301 | PIPELINE | CELLDEX THERAPEUTICS CDX-301 is soluble, recombinant human FMS-like tyrosine kinase-3 ligand (Flt3L) that acts by uniquely binding FMS-like tyrosine kinase-3 (Flt3, CD135), which is expressed on hematopoietic stem cells (HSC), early progenitor cells, immature thymocytes, and steady state dendritic cells, resulting in the proliferation, differentiation, development and mobilization of these cells in the bone marrow CDX-0159 | PIPELINE | CELLDEX THERAPEUTICS CDX-0159 – A Potent KIT Inhibitor. CDX-0159 is a humanized monoclonal antibody that specifically binds the receptor tyrosine kinase KIT with high specificity and potently inhibits its activity. KIT is expressed in a variety of cells, including mast cells, which mediate inflammatory responses such as hypersensitivity and allergicreactions.
SIMULTANEOUS DE-REPRESSION OF INNATE AND ADAPTIVE IMMUNE Simultaneous De-repression of Innate and Adaptive Immune Responses Through Dual Targeting of ILT4 and PD-(L)1 with Bispecific An tibodies. 1. Laura Vitale, AN AXL-TARGETING MONOCLONAL ANTIBODY THAT INHIBITS AXL An Axl-targeting Monoclonal Antibody that Inhibits Axl Activity and Potently Stimulates the Innate Immune Response Diego Alvarado 1, Laura Vitale 2, Mike Murphy , Thomas O’Neill, Edward Natoli1, Jay Lillquist1, Linda Crew1, Anna Wasiuk 2, Jeff Weidlick , Crystal Sisson , Jenifer Widger2, Laura Mills-Chen2, Andrea Crocker , Colleen Patterson , James Boyer 3, Eric Forsberg , April R. Baronas 3 PHASE 1 STUDY OF THE CD40 AGONIST MONOCLONAL ANTIBODY (MAB Phase 1 study of the CD40 agonist monoclonal antibody (mAb) CDX-1140 alone and in combination with CDX -301 (rhFLT3L) in patients withadvanced cancers
INVESTOR RELATIONS
Investor Relations. Celldex is a clinical stage biotechnology company dedicated to developing monoclonal and bispecific antibodies that address devastating diseases for which available treatments are inadequate. Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directlyaffect
CAREERS | ABOUT | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline includes immunotherapies and other targeted biologics derived from a broad set of complementary technologies which have the ability to engage the human immune system and/or directly inhibit tumors to treat specific types of cancer or other diseases. LOCATIONS | ABOUT | CELLDEX THERAPEUTICS 53 Frontage Road, Suite 220. Hampton, NJ 08827. T: (908) 454-7120; F: (908) 454-1911. From the East. Take Route 78 West to exit 12. Take a left at the end of the off-ramp. Take a left at the first traffic light onto Perryville Road. Take a right at the first traffic light onto Frontage road and proceed ~ 0.5 miles. CDX-301 | PIPELINE | CELLDEX THERAPEUTICS CDX-301 is soluble, recombinant human FMS-like tyrosine kinase-3 ligand (Flt3L) that acts by uniquely binding FMS-like tyrosine kinase-3 (Flt3, CD135), which is expressed on hematopoietic stem cells (HSC), early progenitor cells, immature thymocytes, and steady state dendritic cells, resulting in the proliferation, differentiation, development and mobilization of these cells in the bone marrowSTOCK INFORMATION
Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline is built from a proprietary portfolio of antibodies and immunomodulators used alone and in strategic combinations to create novel, disease-specific therapies that induce, enhance or suppress the body's immune response. SIMULTANEOUS DE-REPRESSION OF INNATE AND ADAPTIVE IMMUNE Simultaneous De-repression of Innate and Adaptive Immune Responses Through Dual Targeting of ILT4 and PD-(L)1 with Bispecific An tibodies. 1. Laura Vitale, CONTACT US | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline is built from a proprietary portfolio of antibodies and immunomodulators used alone and in strategic combinations to create novel, disease-specific therapies that induce, enhance or suppress the body's immune response. CDX-1140, A NOVEL AGONIST CD40 ANTIBODY WITH POTENT ANTI Title: CDX-1140, A Novel Agonist CD40 Antibody with Potent Anti-lymphoma Activity Created Date: 12/3/2016 8:40:19 PM CELLDEX THERAPEUTICS ANNOUNCES REVERSE STOCK SPLIT HAMPTON, N.J., Feb. 08, 2019 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (NASDAQ:CLDX) (“Celldex” or the “Company”) today announced that its Board of Directors has approved a one-for-fifteen reverse stock split of its common stock that became effective today upon the filing with the Secretary of the State of Delaware a Certificate of Amendment to its Certificate of Incorporation. DATA FROM MULTIPLE CELLDEX PROGRAMS PRESENTED AT AMERICAN Poster 876: Effective reduction of PD-L1 expression by simultaneous blockade of EGFR and HER3 (ErbB3) in head and neck cancer (Chen, et al ) Investigators examined the effects of combining CDX-3379, a monoclonal antibody targeting ErbB3, and cetuximab, a CELLDEX THERAPEUTICSABOUTPIPELINESCIENCECLINICAL TRIALSINVESTORS &MEDIACDX-0159
Celldex is developing monoclonal and bispecific antibodies that address devastating diseases for which available treatments are inadequate. Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directly effect critical pathways to improve the lives of patients withinflammatory
PIPELINE | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline includes immunotherapies and other targeted biologics derived from a broad set of complementary technologies which have the ability to engage the human immune system and/or directly inhibit tumors to treat specific types of cancer or other diseases. CDX-527 | PIPELINE | CELLDEX THERAPEUTICS CDX-527 is the first candidate from Celldex’s bispecific antibody platform. It uses Celldex’s proprietary highly active anti-PD-L1 and CD27 human antibodies to couple CD27 costimulation with blockade of the PD-L1/PD-1 pathway to help prime and activate anti-tumor T cell responses through CD27 costimulation, while preventing PD-1 inhibitory signals that subvert the immune response.INVESTOR RELATIONS
Investor Relations. Celldex is a clinical stage biotechnology company dedicated to developing monoclonal and bispecific antibodies that address devastating diseases for which available treatments are inadequate. Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directlyaffect
CDX-1140 | PIPELINE | CELLDEX THERAPEUTICS CDX-1140 – A Differentiated CD40 Agonist Antibody. CDX-1140 is a fully human antibody targeted to CD40, a key activator of immune response which is found on dendritic cells, macrophages and B cells and is also expressed on many cancer cells. Potent CD40 agonist antibodies have shown encouraging results in early clinical studies;however
CELLDEX THERAPEUTICS INITIATES PHASE 1B STUDY OF CDX-0159 HAMPTON, N.J., Oct. 13, 2020 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (Nasdaq:CLDX) announced today that enrollment has opened and the first patient has been dosed in its randomized, double-blind Phase 1b study of CDX-0159 in patients with chronic spontaneous urticaria (CSU). CDX-0159 is a humanized monoclonal antibody developed by Celldex that binds the KIT CDX-301 | PIPELINE | CELLDEX THERAPEUTICS CDX-301 is soluble, recombinant human FMS-like tyrosine kinase-3 ligand (Flt3L) that acts by uniquely binding FMS-like tyrosine kinase-3 (Flt3, CD135), which is expressed on hematopoietic stem cells (HSC), early progenitor cells, immature thymocytes, and steady state dendritic cells, resulting in the proliferation, differentiation, development and mobilization of these cells in the bone marrow CDX-0159 | PIPELINE | CELLDEX THERAPEUTICS CDX-0159 – A Potent KIT Inhibitor. CDX-0159 is a humanized monoclonal antibody that specifically binds the receptor tyrosine kinase KIT with high specificity and potently inhibits its activity. KIT is expressed in a variety of cells, including mast cells, which mediate inflammatory responses such as hypersensitivity and allergicreactions.
PHASE 1 STUDY OF THE CD40 AGONIST MONOCLONAL ANTIBODY (MAB Phase 1 study of the CD40 agonist monoclonal antibody (mAb) CDX-1140 alone and in combination with CDX -301 (rhFLT3L) in patients withadvanced cancers
CELLDEX PRESENTS PROMISING DATA FROM CDX-527 BISPECIFIC Celldex Therapeutics, Inc. Logo Celldex Presents Promising Data from CDX-527 Bispecific and TAM Receptor Programs at American Association for Cancer Research (AACR) Annual Meeting 2019 CELLDEX THERAPEUTICSABOUTPIPELINESCIENCECLINICAL TRIALSINVESTORS &MEDIACDX-0159
Celldex is developing monoclonal and bispecific antibodies that address devastating diseases for which available treatments are inadequate. Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directly effect critical pathways to improve the lives of patients withinflammatory
PIPELINE | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline includes immunotherapies and other targeted biologics derived from a broad set of complementary technologies which have the ability to engage the human immune system and/or directly inhibit tumors to treat specific types of cancer or other diseases. CDX-527 | PIPELINE | CELLDEX THERAPEUTICS CDX-527 is the first candidate from Celldex’s bispecific antibody platform. It uses Celldex’s proprietary highly active anti-PD-L1 and CD27 human antibodies to couple CD27 costimulation with blockade of the PD-L1/PD-1 pathway to help prime and activate anti-tumor T cell responses through CD27 costimulation, while preventing PD-1 inhibitory signals that subvert the immune response.INVESTOR RELATIONS
Investor Relations. Celldex is a clinical stage biotechnology company dedicated to developing monoclonal and bispecific antibodies that address devastating diseases for which available treatments are inadequate. Our pipeline includes antibody-based therapeutics which have the ability to engage the human immune system and/or directlyaffect
CDX-1140 | PIPELINE | CELLDEX THERAPEUTICS CDX-1140 – A Differentiated CD40 Agonist Antibody. CDX-1140 is a fully human antibody targeted to CD40, a key activator of immune response which is found on dendritic cells, macrophages and B cells and is also expressed on many cancer cells. Potent CD40 agonist antibodies have shown encouraging results in early clinical studies;however
CELLDEX THERAPEUTICS INITIATES PHASE 1B STUDY OF CDX-0159 HAMPTON, N.J., Oct. 13, 2020 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (Nasdaq:CLDX) announced today that enrollment has opened and the first patient has been dosed in its randomized, double-blind Phase 1b study of CDX-0159 in patients with chronic spontaneous urticaria (CSU). CDX-0159 is a humanized monoclonal antibody developed by Celldex that binds the KIT CDX-301 | PIPELINE | CELLDEX THERAPEUTICS CDX-301 is soluble, recombinant human FMS-like tyrosine kinase-3 ligand (Flt3L) that acts by uniquely binding FMS-like tyrosine kinase-3 (Flt3, CD135), which is expressed on hematopoietic stem cells (HSC), early progenitor cells, immature thymocytes, and steady state dendritic cells, resulting in the proliferation, differentiation, development and mobilization of these cells in the bone marrow CDX-0159 | PIPELINE | CELLDEX THERAPEUTICS CDX-0159 – A Potent KIT Inhibitor. CDX-0159 is a humanized monoclonal antibody that specifically binds the receptor tyrosine kinase KIT with high specificity and potently inhibits its activity. KIT is expressed in a variety of cells, including mast cells, which mediate inflammatory responses such as hypersensitivity and allergicreactions.
PHASE 1 STUDY OF THE CD40 AGONIST MONOCLONAL ANTIBODY (MAB Phase 1 study of the CD40 agonist monoclonal antibody (mAb) CDX-1140 alone and in combination with CDX -301 (rhFLT3L) in patients withadvanced cancers
CELLDEX PRESENTS PROMISING DATA FROM CDX-527 BISPECIFIC Celldex Therapeutics, Inc. Logo Celldex Presents Promising Data from CDX-527 Bispecific and TAM Receptor Programs at American Association for Cancer Research (AACR) Annual Meeting 2019 CDX-301 | PIPELINE | CELLDEX THERAPEUTICS CDX-301 is soluble, recombinant human FMS-like tyrosine kinase-3 ligand (Flt3L) that acts by uniquely binding FMS-like tyrosine kinase-3 (Flt3, CD135), which is expressed on hematopoietic stem cells (HSC), early progenitor cells, immature thymocytes, and steady state dendritic cells, resulting in the proliferation, differentiation, development and mobilization of these cells in the bone marrow CAREERS | ABOUT | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline includes immunotherapies and other targeted biologics derived from a broad set of complementary technologies which have the ability to engage the human immune system and/or directly inhibit tumors to treat specific types of cancer or other diseases. CELLDEX PRESENTS DATA FROM ONCOLOGY PORTFOLIO AT SITC 2020 Celldex Presents Data from Oncology Portfolio at SITC 2020. HAMPTON, N.J., Nov. 09, 2020 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (NASDAQ:CLDX) today announced data from multiple presentations at the Society for Immunotherapy of Cancer’s (SITC) 35th Anniversary Annual Meeting & Pre-Conference Programs (SITC 2020). CDX-0159 | PIPELINE | CELLDEX THERAPEUTICS CDX-0159 – A Potent KIT Inhibitor. CDX-0159 is a humanized monoclonal antibody that specifically binds the receptor tyrosine kinase KIT with high specificity and potently inhibits its activity. KIT is expressed in a variety of cells, including mast cells, which mediate inflammatory responses such as hypersensitivity and allergicreactions.
CELLDEX’S KIT INHIBITOR CDX-0159 DEMONSTRATES PROFOUND Celldex’s KIT Inhibitor CDX-0159 Demonstrates Profound, Sustained Dose-dependent Reductions in Plasma Tryptase—an Indicator of Mast Cell Burden—and a Favorable Safety Profile CONTACT US | CELLDEX THERAPEUTICS Celldex is developing targeted therapeutics to address devastating diseases for which available treatments are inadequate. Our pipeline is built from a proprietary portfolio of antibodies and immunomodulators used alone and in strategic combinations to create novel, disease-specific therapies that induce, enhance or suppress the body's immune response. CDX-3379 | PIPELINE | CELLDEX THERAPEUTICS CDX-3379 is a human monoclonal antibody designed to block the activity of ErbB3 (HER3). ErbB3 may be an important receptor regulating cancer cell growth and survival as well as resistance to targeted therapies and is expressed in many cancers, including head and neck, thyroid, breast, lung and gastric cancers, as well as melanoma. VARLILUMAB | PIPELINE | CELLDEX THERAPEUTICS Varlilumab is a fully human monoclonal antibody (mAb) that targets CD27, a critical molecule in the activation pathway of lymphocytes. Like CD40, CD27 can be effectively manipulated with activating antibodies to induce potent anti-tumor responses, and may result in less toxicities due to its restricted expression and regulation. CELLDEX THERAPEUTICS ANNOUNCES REVERSE STOCK SPLIT HAMPTON, N.J., Feb. 08, 2019 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (NASDAQ:CLDX) (“Celldex” or the “Company”) today announced that its Board of Directors has approved a one-for-fifteen reverse stock split of its common stock that became effective today upon the filing with the Secretary of the State of Delaware a Certificate of Amendment to its Certificate of Incorporation. BACKGROUND INHIBITION OF PD-1 AND CD80 MIXED LYMPHOCYTE Combining CD27 costimulation and PD-1 blockade into a bispecific antibody improves T cell activation and anti -tumor activity over combination of individual antibodies* About
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Developing Targeted Therapeutics for Patients with Devastating DiseasesLearn More
ABOUT US
CELLDEX IS DEVELOPING MONOCLONAL AND BISPECIFIC ANTIBODIES THAT ADDRESS DEVASTATING DISEASES FOR WHICH AVAILABLE TREATMENTS ARE INADEQUATE. OUR PIPELINE INCLUDES ANTIBODY-BASED THERAPEUTICS WHICH HAVE THE ABILITY TO ENGAGE THE HUMAN IMMUNE SYSTEM AND/OR DIRECTLY EFFECT CRITICAL PATHWAYS TO IMPROVE THE LIVES OF PATIENTS WITH INFLAMMATORY DISEASES AND MANY FORMS OF CANCER.NEWS
CELLDEX PRESENTS PRELIMINARY DATA FROM ONGOING CDX-527 PHASE 1 DOSE ESCALATION TRIAL AT THE 2021 ASCO ANNUAL MEETING _Fri, 04 Jun 2021 09:01:00 -0400_...
CELLDEX ANNOUNCES ACCEPTANCE OF ABSTRACT FOR CDX-0159 PHASE 1B RESULTS IN INDUCIBLE URTICARIA FOR LATE-BREAKING PRESENTATION AT THE EUROPEAN ACADEMY OF ALLERGY AND CLINICAL IMMUNOLOGY (EAACI) ANNUALCONGRESS 2021
_Tue, 01 Jun 2021 07:31:00 -0400_...
CELLDEX TO PRESENT AT THE JEFFERIES 2021 VIRTUAL HEALTHCARECONFERENCE
_Wed, 26 May 2021 16:01:00 -0400_...
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