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toxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 GPR6 is an orphan GPCR that has enriched expression in the striatopallidal, indirect pathway, medium spiny neurons of the striatum. This pathway is greatly impacted by the loss of the nigro-striatal dopaminergic neurons in Parkinson's disease and modulating this neurocircuitry can be therapeutically beneficial. In this study we describe the in vitro and in vivo pharmacological THE NEGATIVE ALLOSTERIC MODULATOR EU1794-4 REDUCES SINGLE NMDA receptors are ligand-gated ion channels that mediate a slow, Ca2+-permeable component of excitatory synaptic currents. These receptors are involved in several important brain functions, including learning and memory, and have also been implicated in neuropathological conditions and acute central nervous system injury, which has driven therapeutic interest in their modulation. DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 1 Development of CVN424: a selective and novel GPR6 inverse agonist effective in models of Parkinson’s Disease Authors: Nicola L. Brice,Hans H.
CLASSIFICATION OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC DRUGS The pKi values of 13 reference typical and 7 reference atypical antipsychotic drugs (APDs) for rat striatal dopamine D-1 and D-2 receptor binding sites and cortical serotonin (5-HT2) receptor binding sites were determined. The atypical antipsychotics had significantly lower pKi values for the D-2 but not 5-HT2 binding sites. There was a trend for a lower pKi value for the D-1 binding site for DRUGS FOR INSOMNIA BEYOND BENZODIAZEPINES: PHARMACOLOGY D. The Dark Side of Benzodiazepines and Z-Drugs and the Off-Label Use of Other Drugs Although the market for insomnia medications con-tinues to be dominated by BZDs and Z-drugs, both ASPET JOURNALSDRUG METABOLISM AND DISPOSITIONJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Pharmacology Research & Perspectives. PR&P is jointly published by ASPET, the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy HOME | DRUG METABOLISM & DISPOSITIONARTICLESINFORMATIONEDITORIAL BOARDALERTSFEEDBACKOTHER PUBLICATIONS About Drug Metabolism & Disposition. DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression. HOME | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS About Journal of Pharmacology and Experimental Therapeutics. A leading research journal in the field of pharmacology, JPET provides broad coverage of all aspects of the interactions of chemicals with biological systems, including autonomic, behavioral, cardiovascular, cellular, clinical, developmental, gastrointestinal, immuno-, neuro HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 GPR6 is an orphan GPCR that has enriched expression in the striatopallidal, indirect pathway, medium spiny neurons of the striatum. This pathway is greatly impacted by the loss of the nigro-striatal dopaminergic neurons in Parkinson's disease and modulating this neurocircuitry can be therapeutically beneficial. In this study we describe the in vitro and in vivo pharmacological THE NEGATIVE ALLOSTERIC MODULATOR EU1794-4 REDUCES SINGLE NMDA receptors are ligand-gated ion channels that mediate a slow, Ca2+-permeable component of excitatory synaptic currents. These receptors are involved in several important brain functions, including learning and memory, and have also been implicated in neuropathological conditions and acute central nervous system injury, which has driven therapeutic interest in their modulation. DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 1 Development of CVN424: a selective and novel GPR6 inverse agonist effective in models of Parkinson’s Disease Authors: Nicola L. Brice,Hans H.
CLASSIFICATION OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC DRUGS The pKi values of 13 reference typical and 7 reference atypical antipsychotic drugs (APDs) for rat striatal dopamine D-1 and D-2 receptor binding sites and cortical serotonin (5-HT2) receptor binding sites were determined. The atypical antipsychotics had significantly lower pKi values for the D-2 but not 5-HT2 binding sites. There was a trend for a lower pKi value for the D-1 binding site for DRUGS FOR INSOMNIA BEYOND BENZODIAZEPINES: PHARMACOLOGY D. The Dark Side of Benzodiazepines and Z-Drugs and the Off-Label Use of Other Drugs Although the market for insomnia medications con-tinues to be dominated by BZDs and Z-drugs, bothASPET JOURNALS
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E. THE MEASUREMENT OF 4-HYDROXY-3-METHOXYMANDELIC ACID AND HOMOVANILLIC ACID. M. Sandler and C. R. J. Ruthven. Pharmacological Reviews March 1966, 18 (1) 343-351; ASPET JOURNALSDRUG METABOLISM AND DISPOSITIONJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Pharmacology Research & Perspectives. PR&P is jointly published by ASPET, the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy HOME | DRUG METABOLISM & DISPOSITIONARTICLESINFORMATIONEDITORIAL BOARDALERTSFEEDBACKOTHER PUBLICATIONS About Drug Metabolism & Disposition. DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression. HOME | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS About Journal of Pharmacology and Experimental Therapeutics. A leading research journal in the field of pharmacology, JPET provides broad coverage of all aspects of the interactions of chemicals with biological systems, including autonomic, behavioral, cardiovascular, cellular, clinical, developmental, gastrointestinal, immuno-, neuro HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 GPR6 is an orphan GPCR that has enriched expression in the striatopallidal, indirect pathway, medium spiny neurons of the striatum. This pathway is greatly impacted by the loss of the nigro-striatal dopaminergic neurons in Parkinson's disease and modulating this neurocircuitry can be therapeutically beneficial. In this study we describe the in vitro and in vivo pharmacological THE NEGATIVE ALLOSTERIC MODULATOR EU1794-4 REDUCES SINGLE NMDA receptors are ligand-gated ion channels that mediate a slow, Ca2+-permeable component of excitatory synaptic currents. These receptors are involved in several important brain functions, including learning and memory, and have also been implicated in neuropathological conditions and acute central nervous system injury, which has driven therapeutic interest in their modulation. DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 1 Development of CVN424: a selective and novel GPR6 inverse agonist effective in models of Parkinson’s Disease Authors: Nicola L. Brice,Hans H.
CLASSIFICATION OF TYPICAL AND ATYPICAL ANTIPSYCHOTIC DRUGS The pKi values of 13 reference typical and 7 reference atypical antipsychotic drugs (APDs) for rat striatal dopamine D-1 and D-2 receptor binding sites and cortical serotonin (5-HT2) receptor binding sites were determined. The atypical antipsychotics had significantly lower pKi values for the D-2 but not 5-HT2 binding sites. There was a trend for a lower pKi value for the D-1 binding site for DRUGS FOR INSOMNIA BEYOND BENZODIAZEPINES: PHARMACOLOGY D. The Dark Side of Benzodiazepines and Z-Drugs and the Off-Label Use of Other Drugs Although the market for insomnia medications con-tinues to be dominated by BZDs and Z-drugs, both ASPET JOURNALSDRUG METABOLISM AND DISPOSITIONJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Pharmacology Research & Perspectives. PR&P is jointly published by ASPET, the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy HOME | DRUG METABOLISM & DISPOSITIONARTICLESINFORMATIONEDITORIAL BOARDALERTSFEEDBACKOTHER PUBLICATIONS About Drug Metabolism & Disposition. DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression. HOME | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS About Journal of Pharmacology and Experimental Therapeutics. A leading research journal in the field of pharmacology, JPET provides broad coverage of all aspects of the interactions of chemicals with biological systems, including autonomic, behavioral, cardiovascular, cellular, clinical, developmental, gastrointestinal, immuno-, neuro HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 GPR6 is an orphan GPCR that has enriched expression in the striatopallidal, indirect pathway, medium spiny neurons of the striatum. This pathway is greatly impacted by the loss of the nigro-striatal dopaminergic neurons in Parkinson's disease and modulating this neurocircuitry can be therapeutically beneficial. In this study we describe the in vitro and in vivo pharmacological THE NEGATIVE ALLOSTERIC MODULATOR EU1794-4 REDUCES SINGLE NMDA receptors are ligand-gated ion channels that mediate a slow, Ca2+-permeable component of excitatory synaptic currents. These receptors are involved in several important brain functions, including learning and memory, and have also been implicated in neuropathological conditions and acute central nervous system injury, which has driven therapeutic interest in their modulation. DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 1 Development of CVN424: a selective and novel GPR6 inverse agonist effective in models of Parkinson’s Disease Authors: Nicola L. Brice,Hans H.
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DISCOVERY OF M5049: A NOVEL SELECTIVE TLR7/8 INHIBITOR FOR1 Toll-like receptors 7 and 8 (TLR7/8) are transmembrane receptors that recognize single-stranded RNA. Activation of these receptors results in immune cell stimulation and inflammatory cytokine production which is normally a protective host response. However, aberrant activation of TLR7/8 is potentially pathogenic and linked to progression of certain autoimmune diseases such as lupus. CYTOCHROME P450 3A TIME-DEPENDENT INHIBITION ASSAYS ARE Time-dependent inhibition (TDI) of cytochrome P450 3A (CYP3A) is an important mechanism underlying numerous drug-drug interactions (DDI), and assays to measure this are done to support early drug research efforts. However, measuring TDI of CYP3A in human liver microsomes (HLM) frequently yields over-estimations of clinical DDI, and thus can lead to the erroneous elimination of HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
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DISCOVERY OF M5049: A NOVEL SELECTIVE TLR7/8 INHIBITOR FOR1 Toll-like receptors 7 and 8 (TLR7/8) are transmembrane receptors that recognize single-stranded RNA. Activation of these receptors results in immune cell stimulation and inflammatory cytokine production which is normally a protective host response. However, aberrant activation of TLR7/8 is potentially pathogenic and linked to progression of certain autoimmune diseases such as lupus. CYTOCHROME P450 3A TIME-DEPENDENT INHIBITION ASSAYS ARE Time-dependent inhibition (TDI) of cytochrome P450 3A (CYP3A) is an important mechanism underlying numerous drug-drug interactions (DDI), and assays to measure this are done to support early drug research efforts. However, measuring TDI of CYP3A in human liver microsomes (HLM) frequently yields over-estimations of clinical DDI, and thus can lead to the erroneous elimination of DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 GPR6 is an orphan GPCR that has enriched expression in the striatopallidal, indirect pathway, medium spiny neurons of the striatum. This pathway is greatly impacted by the loss of the nigro-striatal dopaminergic neurons in Parkinson's disease and modulating this neurocircuitry can be therapeutically beneficial. In this study we describe the in vitro and in vivo pharmacological HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. THE NEGATIVE ALLOSTERIC MODULATOR EU1794-4 REDUCES SINGLE NMDA receptors are ligand-gated ion channels that mediate a slow, Ca2+-permeable component of excitatory synaptic currents. These receptors are involved in several important brain functions, including learning and memory, and have also been implicated in neuropathological conditions and acute central nervous system injury, which has driven therapeutic interest in their modulation. INHIBITION OF G6PD ACTIVITY ATTENUATES RIGHT VENTRICLE 1 Title . Inhibition of G6PD activity attenuates right ventricle pressure and hypertrophy elicited by VEGFR inhibitor + hypoxia . Atsushi Kitagawa,1 Christina Jacob,1 Allan Jordan,2 Ian Waddell,2 Ivan F. McMurtry,3 Sachin A Gupte1*. 1Department of Pharmacology, New York Medical College, Valhalla, NYASPET JOURNALS
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DISCOVERY OF M5049: A NOVEL SELECTIVE TLR7/8 INHIBITOR FOR1 Toll-like receptors 7 and 8 (TLR7/8) are transmembrane receptors that recognize single-stranded RNA. Activation of these receptors results in immune cell stimulation and inflammatory cytokine production which is normally a protective host response. However, aberrant activation of TLR7/8 is potentially pathogenic and linked to progression of certain autoimmune diseases such as lupus. CYTOCHROME P450 3A TIME-DEPENDENT INHIBITION ASSAYS ARE Time-dependent inhibition (TDI) of cytochrome P450 3A (CYP3A) is an important mechanism underlying numerous drug-drug interactions (DDI), and assays to measure this are done to support early drug research efforts. However, measuring TDI of CYP3A in human liver microsomes (HLM) frequently yields over-estimations of clinical DDI, and thus can lead to the erroneous elimination of HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 GPR6 is an orphan GPCR that has enriched expression in the striatopallidal, indirect pathway, medium spiny neurons of the striatum. This pathway is greatly impacted by the loss of the nigro-striatal dopaminergic neurons in Parkinson's disease and modulating this neurocircuitry can be therapeutically beneficial. In this study we describe the in vitro and in vivo pharmacological HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. THE NEGATIVE ALLOSTERIC MODULATOR EU1794-4 REDUCES SINGLE NMDA receptors are ligand-gated ion channels that mediate a slow, Ca2+-permeable component of excitatory synaptic currents. These receptors are involved in several important brain functions, including learning and memory, and have also been implicated in neuropathological conditions and acute central nervous system injury, which has driven therapeutic interest in their modulation. INHIBITION OF G6PD ACTIVITY ATTENUATES RIGHT VENTRICLE 1 Title . Inhibition of G6PD activity attenuates right ventricle pressure and hypertrophy elicited by VEGFR inhibitor + hypoxia . Atsushi Kitagawa,1 Christina Jacob,1 Allan Jordan,2 Ian Waddell,2 Ivan F. McMurtry,3 Sachin A Gupte1*. 1Department of Pharmacology, New York Medical College, Valhalla, NY ASPET JOURNALSDRUG METABOLISM AND DISPOSITIONJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Pharmacology Research & Perspectives. PR&P is jointly published by ASPET, the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy HOME | DRUG METABOLISM & DISPOSITIONARTICLESINFORMATIONEDITORIAL BOARDALERTSFEEDBACKOTHER PUBLICATIONS About Drug Metabolism & Disposition. DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression. HOME | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Liver-specific, non-viral gene delivery of fibroblast growth factor 21 protein expression in mice regulates body mass and white/brown fatrespiration
DISCOVERY OF M5049: A NOVEL SELECTIVE TLR7/8 INHIBITOR FOR1 Toll-like receptors 7 and 8 (TLR7/8) are transmembrane receptors that recognize single-stranded RNA. Activation of these receptors results in immune cell stimulation and inflammatory cytokine production which is normally a protective host response. However, aberrant activation of TLR7/8 is potentially pathogenic and linked to progression of certain autoimmune diseases such as lupus. CYTOCHROME P450 3A TIME-DEPENDENT INHIBITION ASSAYS ARE Time-dependent inhibition (TDI) of cytochrome P450 3A (CYP3A) is an important mechanism underlying numerous drug-drug interactions (DDI), and assays to measure this are done to support early drug research efforts. However, measuring TDI of CYP3A in human liver microsomes (HLM) frequently yields over-estimations of clinical DDI, and thus can lead to the erroneous elimination of HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
DEVELOPMENT OF CVN424: A SELECTIVE AND NOVEL GPR6 INVERSE1 GPR6 is an orphan GPCR that has enriched expression in the striatopallidal, indirect pathway, medium spiny neurons of the striatum. This pathway is greatly impacted by the loss of the nigro-striatal dopaminergic neurons in Parkinson's disease and modulating this neurocircuitry can be therapeutically beneficial. In this study we describe the in vitro and in vivo pharmacological HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. THE NEGATIVE ALLOSTERIC MODULATOR EU1794-4 REDUCES SINGLE NMDA receptors are ligand-gated ion channels that mediate a slow, Ca2+-permeable component of excitatory synaptic currents. These receptors are involved in several important brain functions, including learning and memory, and have also been implicated in neuropathological conditions and acute central nervous system injury, which has driven therapeutic interest in their modulation. INHIBITION OF G6PD ACTIVITY ATTENUATES RIGHT VENTRICLE 1 Title . Inhibition of G6PD activity attenuates right ventricle pressure and hypertrophy elicited by VEGFR inhibitor + hypoxia . Atsushi Kitagawa,1 Christina Jacob,1 Allan Jordan,2 Ian Waddell,2 Ivan F. McMurtry,3 Sachin A Gupte1*. 1Department of Pharmacology, New York Medical College, Valhalla, NYASPET JOURNALS
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International Union of Basic and Clinical Pharmacology CIV: The Neurobiology of Treatment-resistant Depression: From Antidepressant Classifications to Novel Pharmacological Targets ASPET JOURNALSDRUG METABOLISM AND DISPOSITIONJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Pharmacology Research & Perspectives. PR&P is jointly published by ASPET, the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy HOME | DRUG METABOLISM & DISPOSITIONARTICLESINFORMATIONEDITORIAL BOARDALERTSFEEDBACKOTHER PUBLICATIONS Drug Metabolism and Disposition June 1, 2021, DMD-AR-2020-000340; DOI: https://doi.org/10.1124/dmd.120.000340 HOME | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Liver-specific, non-viral gene delivery of fibroblast growth factor 21 protein expression in mice regulates body mass and white/brown fatrespiration
HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. ABSORPTION, METABOLISM, AND EXCRETION OF ETORICOXIB, A Etoricoxib (100 μCi/dose) was administered to six healthy male subjects (i.v., 25 mg; p.o., 100 mg). Following the i.v. dose, the plasma clearance was 57 ml/min, and the harmonic mean half-life was 24.8 h. Etoricoxib accounted for the majority of the radioactivity (∼75%) present in plasma following both i.v. and p.o. doses. The oral dose, administered as a solution in polyethylene CARBON MONOXIDE: ENDOGENOUS PRODUCTION, PHYSIOLOGICAL Over the last decade, studies have unraveled many aspects of endogenous production and physiological functions of carbon monoxide (CO). The majority of endogenous CO is produced in a reaction catalyzed by the enzyme heme oxygenase (HO). Inducible HO (HO-1) and constitutive HO (HO-2) are mostly recognized for their roles in the oxidation of heme and production of CO and biliverdin, ANIMAL MODELS OF NOCICEPTION The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them. Philosophically, there is the problem that pain cannot be monitored directly in animals but can only be estimated by examining their responses to nociceptive THEORETICAL BASIS, EXPERIMENTAL DESIGN, AND COMPUTERIZED The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and deduction for different reaction sequences and mechanisms and different types of inhibition has been shown to be the unified theory for the Michaelis-Menten equation, Hill equation, Henderson-Hasselbalch equation, and Scatchard equation. It is shown that VANILLOID (CAPSAICIN) RECEPTORS AND MECHANISMS Vanilloid (Capsaicin) Receptors and Mechanisms. Arpad Szallasi and Peter M. Blumberg. Pharmacological Reviews June 1999, 51 (2) 159-212; Arpad Szallasi. Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland. Find this author on GoogleScholar.
ASPET JOURNALSDRUG METABOLISM AND DISPOSITIONJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Pharmacology Research & Perspectives. PR&P is jointly published by ASPET, the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy HOME | DRUG METABOLISM & DISPOSITIONARTICLESINFORMATIONEDITORIAL BOARDALERTSFEEDBACKOTHER PUBLICATIONS Drug Metabolism and Disposition June 1, 2021, DMD-AR-2020-000340; DOI: https://doi.org/10.1124/dmd.120.000340 HOME | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Liver-specific, non-viral gene delivery of fibroblast growth factor 21 protein expression in mice regulates body mass and white/brown fatrespiration
HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. ABSORPTION, METABOLISM, AND EXCRETION OF ETORICOXIB, A Etoricoxib (100 μCi/dose) was administered to six healthy male subjects (i.v., 25 mg; p.o., 100 mg). Following the i.v. dose, the plasma clearance was 57 ml/min, and the harmonic mean half-life was 24.8 h. Etoricoxib accounted for the majority of the radioactivity (∼75%) present in plasma following both i.v. and p.o. doses. The oral dose, administered as a solution in polyethylene CARBON MONOXIDE: ENDOGENOUS PRODUCTION, PHYSIOLOGICAL Over the last decade, studies have unraveled many aspects of endogenous production and physiological functions of carbon monoxide (CO). The majority of endogenous CO is produced in a reaction catalyzed by the enzyme heme oxygenase (HO). Inducible HO (HO-1) and constitutive HO (HO-2) are mostly recognized for their roles in the oxidation of heme and production of CO and biliverdin, ANIMAL MODELS OF NOCICEPTION The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them. Philosophically, there is the problem that pain cannot be monitored directly in animals but can only be estimated by examining their responses to nociceptive THEORETICAL BASIS, EXPERIMENTAL DESIGN, AND COMPUTERIZED The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and deduction for different reaction sequences and mechanisms and different types of inhibition has been shown to be the unified theory for the Michaelis-Menten equation, Hill equation, Henderson-Hasselbalch equation, and Scatchard equation. It is shown that VANILLOID (CAPSAICIN) RECEPTORS AND MECHANISMS Vanilloid (Capsaicin) Receptors and Mechanisms. Arpad Szallasi and Peter M. Blumberg. Pharmacological Reviews June 1999, 51 (2) 159-212; Arpad Szallasi. Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland. Find this author on GoogleScholar.
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HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. ABSORPTION, METABOLISM, AND EXCRETION OF ETORICOXIB, A Etoricoxib (100 μCi/dose) was administered to six healthy male subjects (i.v., 25 mg; p.o., 100 mg). Following the i.v. dose, the plasma clearance was 57 ml/min, and the harmonic mean half-life was 24.8 h. Etoricoxib accounted for the majority of the radioactivity (∼75%) present in plasma following both i.v. and p.o. doses. The oral dose, administered as a solution in polyethylene CARBON MONOXIDE: ENDOGENOUS PRODUCTION, PHYSIOLOGICAL Over the last decade, studies have unraveled many aspects of endogenous production and physiological functions of carbon monoxide (CO). The majority of endogenous CO is produced in a reaction catalyzed by the enzyme heme oxygenase (HO). Inducible HO (HO-1) and constitutive HO (HO-2) are mostly recognized for their roles in the oxidation of heme and production of CO and biliverdin, ANIMAL MODELS OF NOCICEPTION The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them. Philosophically, there is the problem that pain cannot be monitored directly in animals but can only be estimated by examining their responses to nociceptive THEORETICAL BASIS, EXPERIMENTAL DESIGN, AND COMPUTERIZED The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and deduction for different reaction sequences and mechanisms and different types of inhibition has been shown to be the unified theory for the Michaelis-Menten equation, Hill equation, Henderson-Hasselbalch equation, and Scatchard equation. It is shown that VANILLOID (CAPSAICIN) RECEPTORS AND MECHANISMSVANILLOID CAPSAICIN RECEPTORS AND MECHANIS…VANILLOID RECEPTORVANILLOID SYSTEMTRPV1 RECEPTORS FUNCTIONWHAT IS TRPV1 AND CAPSAICINTRPV1 RECEPTORS CAPSAICIN Vanilloid (Capsaicin) Receptors and Mechanisms. Arpad Szallasi and Peter M. Blumberg. Pharmacological Reviews June 1999, 51 (2) 159-212; Arpad Szallasi. Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland. Find this author on GoogleScholar.
ASPET JOURNALSDRUG METABOLISM AND DISPOSITIONJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Pharmacology Research & Perspectives. PR&P is jointly published by ASPET, the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy HOME | DRUG METABOLISM & DISPOSITIONARTICLESINFORMATIONEDITORIAL BOARDALERTSFEEDBACKOTHER PUBLICATIONS Drug Metabolism and Disposition June 1, 2021, DMD-AR-2020-000340; DOI: https://doi.org/10.1124/dmd.120.000340 HOME | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Liver-specific, non-viral gene delivery of fibroblast growth factor 21 protein expression in mice regulates body mass and white/brown fatrespiration
HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. ABSORPTION, METABOLISM, AND EXCRETION OF ETORICOXIB, A Etoricoxib (100 μCi/dose) was administered to six healthy male subjects (i.v., 25 mg; p.o., 100 mg). Following the i.v. dose, the plasma clearance was 57 ml/min, and the harmonic mean half-life was 24.8 h. Etoricoxib accounted for the majority of the radioactivity (∼75%) present in plasma following both i.v. and p.o. doses. The oral dose, administered as a solution in polyethylene CARBON MONOXIDE: ENDOGENOUS PRODUCTION, PHYSIOLOGICAL Over the last decade, studies have unraveled many aspects of endogenous production and physiological functions of carbon monoxide (CO). The majority of endogenous CO is produced in a reaction catalyzed by the enzyme heme oxygenase (HO). Inducible HO (HO-1) and constitutive HO (HO-2) are mostly recognized for their roles in the oxidation of heme and production of CO and biliverdin, ANIMAL MODELS OF NOCICEPTION The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them. Philosophically, there is the problem that pain cannot be monitored directly in animals but can only be estimated by examining their responses to nociceptive THEORETICAL BASIS, EXPERIMENTAL DESIGN, AND COMPUTERIZED The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and deduction for different reaction sequences and mechanisms and different types of inhibition has been shown to be the unified theory for the Michaelis-Menten equation, Hill equation, Henderson-Hasselbalch equation, and Scatchard equation. It is shown that VANILLOID (CAPSAICIN) RECEPTORS AND MECHANISMSVANILLOID CAPSAICIN RECEPTORS AND MECHANIS…VANILLOID RECEPTORVANILLOID SYSTEMTRPV1 RECEPTORS FUNCTIONWHAT IS TRPV1 AND CAPSAICINTRPV1 RECEPTORS CAPSAICIN Vanilloid (Capsaicin) Receptors and Mechanisms. Arpad Szallasi and Peter M. Blumberg. Pharmacological Reviews June 1999, 51 (2) 159-212; Arpad Szallasi. Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland. Find this author on GoogleScholar.
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THE PHARMACOLOGICAL ACTIVITY OF EPINEPHRINE AND RELATED DIHYDROXYPHENYLALKYLAMINES. A. M. LANDS. Pharmacological Reviews August 1949, 1 (2) 279-309; ASPET JOURNALSDRUG METABOLISM AND DISPOSITIONJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Pharmacology Research & Perspectives. PR&P is jointly published by ASPET, the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy HOME | DRUG METABOLISM & DISPOSITIONARTICLESINFORMATIONEDITORIAL BOARDALERTSFEEDBACKOTHER PUBLICATIONS Drug Metabolism and Disposition June 1, 2021, DMD-AR-2020-000340; DOI: https://doi.org/10.1124/dmd.120.000340 HOME | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Liver-specific, non-viral gene delivery of fibroblast growth factor 21 protein expression in mice regulates body mass and white/brown fatrespiration
HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. ABSORPTION, METABOLISM, AND EXCRETION OF ETORICOXIB, A Etoricoxib (100 μCi/dose) was administered to six healthy male subjects (i.v., 25 mg; p.o., 100 mg). Following the i.v. dose, the plasma clearance was 57 ml/min, and the harmonic mean half-life was 24.8 h. Etoricoxib accounted for the majority of the radioactivity (∼75%) present in plasma following both i.v. and p.o. doses. The oral dose, administered as a solution in polyethylene CARBON MONOXIDE: ENDOGENOUS PRODUCTION, PHYSIOLOGICAL Over the last decade, studies have unraveled many aspects of endogenous production and physiological functions of carbon monoxide (CO). The majority of endogenous CO is produced in a reaction catalyzed by the enzyme heme oxygenase (HO). Inducible HO (HO-1) and constitutive HO (HO-2) are mostly recognized for their roles in the oxidation of heme and production of CO and biliverdin, ANIMAL MODELS OF NOCICEPTION The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them. Philosophically, there is the problem that pain cannot be monitored directly in animals but can only be estimated by examining their responses to nociceptive THEORETICAL BASIS, EXPERIMENTAL DESIGN, AND COMPUTERIZED The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and deduction for different reaction sequences and mechanisms and different types of inhibition has been shown to be the unified theory for the Michaelis-Menten equation, Hill equation, Henderson-Hasselbalch equation, and Scatchard equation. It is shown that VANILLOID (CAPSAICIN) RECEPTORS AND MECHANISMSVANILLOID CAPSAICIN RECEPTORS AND MECHANIS…VANILLOID RECEPTORVANILLOID SYSTEMTRPV1 RECEPTORS FUNCTIONWHAT IS TRPV1 AND CAPSAICINTRPV1 RECEPTORS CAPSAICIN Vanilloid (Capsaicin) Receptors and Mechanisms. Arpad Szallasi and Peter M. Blumberg. Pharmacological Reviews June 1999, 51 (2) 159-212; Arpad Szallasi. Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland. Find this author on GoogleScholar.
ASPET JOURNALSDRUG METABOLISM AND DISPOSITIONJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Pharmacology Research & Perspectives. PR&P is jointly published by ASPET, the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy HOME | DRUG METABOLISM & DISPOSITIONARTICLESINFORMATIONEDITORIAL BOARDALERTSFEEDBACKOTHER PUBLICATIONS Drug Metabolism and Disposition June 1, 2021, DMD-AR-2020-000340; DOI: https://doi.org/10.1124/dmd.120.000340 HOME | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS Liver-specific, non-viral gene delivery of fibroblast growth factor 21 protein expression in mice regulates body mass and white/brown fatrespiration
HOME | MOLECULAR PHARMACOLOGY About Molecular Pharmacology. Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology andtoxicology.
HOME | PHARMACOLOGICAL REVIEWS Pharmacological Reviews presents important review articles covering the broad spectrum of pharmacological research. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. ABSORPTION, METABOLISM, AND EXCRETION OF ETORICOXIB, A Etoricoxib (100 μCi/dose) was administered to six healthy male subjects (i.v., 25 mg; p.o., 100 mg). Following the i.v. dose, the plasma clearance was 57 ml/min, and the harmonic mean half-life was 24.8 h. Etoricoxib accounted for the majority of the radioactivity (∼75%) present in plasma following both i.v. and p.o. doses. The oral dose, administered as a solution in polyethylene CARBON MONOXIDE: ENDOGENOUS PRODUCTION, PHYSIOLOGICAL Over the last decade, studies have unraveled many aspects of endogenous production and physiological functions of carbon monoxide (CO). The majority of endogenous CO is produced in a reaction catalyzed by the enzyme heme oxygenase (HO). Inducible HO (HO-1) and constitutive HO (HO-2) are mostly recognized for their roles in the oxidation of heme and production of CO and biliverdin, ANIMAL MODELS OF NOCICEPTION The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them. Philosophically, there is the problem that pain cannot be monitored directly in animals but can only be estimated by examining their responses to nociceptive THEORETICAL BASIS, EXPERIMENTAL DESIGN, AND COMPUTERIZED The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and deduction for different reaction sequences and mechanisms and different types of inhibition has been shown to be the unified theory for the Michaelis-Menten equation, Hill equation, Henderson-Hasselbalch equation, and Scatchard equation. It is shown that VANILLOID (CAPSAICIN) RECEPTORS AND MECHANISMSVANILLOID CAPSAICIN RECEPTORS AND MECHANIS…VANILLOID RECEPTORVANILLOID SYSTEMTRPV1 RECEPTORS FUNCTIONWHAT IS TRPV1 AND CAPSAICINTRPV1 RECEPTORS CAPSAICIN Vanilloid (Capsaicin) Receptors and Mechanisms. Arpad Szallasi and Peter M. Blumberg. Pharmacological Reviews June 1999, 51 (2) 159-212; Arpad Szallasi. Molecular Mechanisms of Tumor Promotion Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland. Find this author on GoogleScholar.
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* __ Visit aspet on Facebook * __ Follow aspet on Twitter * __ Follow aspet on Google Plus ASPET'S 2021 INSTITUTIONAL SUBSCRIPTION PRICES ARE NOW AVAILABLE DRUG METABOLISM AND DISPOSITION An important reference for all pharmacology and toxicology departments, DMD is also a valuable resource for medicinal chemists involved in drug design and biochemists with an interest in drug metabolism, expression of drug metabolizing enzymes, and regulation of drug metabolizing enzyme gene expression. Articles provide experimental results from in vitro and in vivo systems that bring you significant and original information on metabolism and disposition of endogenous and exogenous compounds, including pharmacologic agents and environmental chemicals. ------------------------- THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS A leading research journal in the field of pharmacology, JPET provides broad coverage of all aspects of the interactions of chemicals with biological systems, including autonomic, behavioral, cardiovascular, cellular, clinical, developmental, gastrointestinal, immuno-, neuro-, pulmonary, and renal pharmacology, as well as analgesics, drug abuse, metabolism and disposition, chemotherapy, and toxicology. The Special Libraries Association has included JPET in its DBIO 100, the "100 most influential journals of biology and medicine over the 100 years of theassociation.
------------------------- MOLECULAR PHARMACOLOGY Monthly issues present original applications of biochemistry, biophysics, genetics, and molecular biology juxtaposed with innovative pharmacologic research to elucidate basic problems in pharmacology and toxicology, including areas such as molecular mechanisms involved in drug receptor-effector coupling, xenobiotic metabolism, and antibiotic and anticancer drug action. ------------------------- PHARMACOLOGICAL REVIEWS This quarterly journal showcases important review articles on topics of high current interest. Topics covered have included biochemical and cellular pharmacology, drug metabolism and disposition, renal pharmacology, neuropharmacology, behavioral pharmacology, clinical pharmacology, and toxicology. IUPHAR nomenclature reports arepublished here.
------------------------- PHARMACOLOGY RESEARCH & PERSPECTIVES PR&P is jointly published by ASPET, the British Pharmacological Society (BPS), and Wiley. PR&P is a bi-monthly open access journal that publishes a range of article types, including: target validation (preclinical papers that show a hypothesis is incorrect or papers on drugs that have failed in early clinical development); drug discovery reviews (strategy, hypotheses, and data resulting in a successful therapeutic drug); frontiers in translational medicine (drug and target validation for an unmet therapeutic need); pharmacological hypotheses (reviews that are oriented to inform a novel hypothesis); and replication studies (work that refutes key findings and work that validates key findings). PR&P publishes papers submitted directly to the journal and those referred from the journals of ASPET and the BPS.* Home
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