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FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Address. Friedrich Miescher Institute for Biomedical Research Maulbeerstrasse 66 4058 Basel Switzerland Tel: +41 61 697 66 51 Fax: +41 61 697 39 76 E-mail: office@fmi.ch Opening hours: 7.45 - FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH A cell is an ensemble of molecules that interact together and form a complex network of molecular interactions. This network organizes biological processes and cellular functions and determines the phenotype of the cell. Mutations quantitatively perturb the way proteins interact with each other and with other molecules. FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Jan 25, 2021. Prisca Liberali awarded prestigious Friedrich Miescher Award. Oct 8, 2020. Intestinal regeneration: lessons from organoid research. Aug 31, 2020. FMI is a partner in the new EU “HCA|Organoid” project. Nov 18, 2019. Prisca Liberali becomes an FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCHHISTORYEXTRANET (FMI ONLY) The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research. 340. People. FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Our research is aimed at further understanding, at the level of individual gene loci and genome-wide, how these nuclear events influence the expression phenotype in higher eukaryotes and how they are propagated during cell division. Contact. Dirk Schübeler. This is a list of selected publications from this group. FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH In our lab, we explore the biophysical mechanisms that link chromosome conformation and long-range transcriptional regulation in mouse embryonic stem cells (ESC) and differentiated derivatives, using molecular biology, genetic engineering, single-cell FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Thus, genetic and epigenetic information is faithfully passaged to the progeny. On a biomedical level, defects in these pathways are frequently associated with cancer. Genome integrity is maintained through large multi-component nano-machines. We focus on protein complexes at the interface of DNA repair, replication and chromatin. FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Antoine H.F.M. Peters. This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name. Stäubli A. and A.H.F.M. Peters (2021) Mechanisms of maternal intergenerational epigenetic inheritance. Current Opinion in Genetics & Developmental 67: 151-162(open access).
FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Address. Friedrich Miescher Institute for Biomedical Research Maulbeerstrasse 66 4058 Basel Switzerland Tel: +41 61 697 66 51 Fax: +41 61 697 39 76 E-mail: office@fmi.ch Opening hours: 7.45 - FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH A cell is an ensemble of molecules that interact together and form a complex network of molecular interactions. This network organizes biological processes and cellular functions and determines the phenotype of the cell. Mutations quantitatively perturb the way proteins interact with each other and with other molecules.FMI - ARTICLE
Starting a PhD can be daunting, especially during a pandemic, when uncertainty and social isolation can cause some extra emotional and logistical upheavals. That’s why the FMI launched a ‘mentor matching’ initiative. By pairing senior PhD students with students who joined the institute during the COVID-19 pandemic, the initiative aims at helping newcomers meet their peers, navigate FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Our research is aimed at further understanding, at the level of individual gene loci and genome-wide, how these nuclear events influence the expression phenotype in higher eukaryotes and how they are propagated during cell division. Contact. Dirk Schübeler. This is a list of selected publications from this group. FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH This work bridges the gap between experiment and theory. Additional research focuses on circuit dysfunctions in genetic models of autism spectrum disorders and other diseases. The goal of this research is to obtain deeper insights into disease mechanisms at the level of neuronal circuit structure and function. Contact. FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Antoine H.F.M. Peters. This is a list of selected publications from this group. For a full list of publications, please visit our Publications page and search by group name. Stäubli A. and A.H.F.M. Peters (2021) Mechanisms of maternal intergenerational epigenetic inheritance. Current Opinion in Genetics & Developmental 67: 151-162(open access).
FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Oct 21, 2020 How the visual cortex combines movement and vision Feb 12, 2019 Alexander Attinger and Bo Wang awarded Pfizer Research Prize2019
FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Zenke, F., and Neftci, E.O. (2021) Brain-Inspired Learning on Neuromorphic Substrates. Proceedings of the IEEE 1-16. Cramer, B., Stradmann, Y., Schemmel, J., and Zenke, F. (2020) The Heidelberg Spiking Data Sets for the Systematic Evaluation of Spiking Neural Networks. IEEE Transactions on Neural Networks and Learning Systems1-14.
FMI - FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH Assistant Professor for Neurobiology/Cell Biology, Biozentrum, University of Basel, Basel and Friedrich Miescher Institute for Biomedical Research,Basel, Switzerland. 1996-2000. Postdoctoral Fellow, Columbia University, HHMI, New York.FMI - ARTICLE
Molecular glue degraders are a new class of drugs that work by facilitating an interaction between a disease-causing target protein and a ubiquitin ligase complex, tagging the target protein for degradation. In this new video, members of the Thomä group, in collaboration with the Broad Institute, explain how they identified and characterized a new molecular glue degrader compound called CR8 FMI - OPENIRIS.IO - HOME Registration provides a more in-depth view of resource providers available to you. See providers. 25304 users. 8844 resources. 845 providers. 528 organizations.FMI - ARTICLE
The selection of research projects to be funded by the European Research Council (ERC) is highly competitive; therefore, the funding of a project by the ERC is a key indicator for research excellence. In the latest data provided by the ERC covering the years 2014-2018, the FMI achieved a remarkable success rate of 75%, ranking first of 172institutes.
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LATEST NEWS
Nov 26, 2020
FOREIGN VS. OWN DNA: HOW AN INNATE IMMUNE SENSOR TELLS FRIEND FROM FOE__
How do molecules involved in activating our immune system discriminate between our own DNA and foreign pathogens? Researchers from the Thomä group, in collaboration with the EPFL, deciphered the structural and functional basis of a DNA-sensing molecule when it comes in contact with the cell’s own DNA, providing crucial insights into the recognition of self vs. non-self DNA.Nov 02, 2020
BUILDING ARTIFICIAL NEURAL NETWORKS INSPIRED BY THE BRAIN__
Oct 21, 2020
HOW THE VISUAL CORTEX COMBINES MOVEMENT AND VISION__
ABOUT THE FMI
The Friedrich Miescher Institute for Biomedical Research (FMI), based in Basel, Switzerland, is a world-class biomedical research institute, affiliated with the University of Basel and the Novartis Institutes for Biomedical Research.340 People
43 Nationalities
21 Research Groups
131 Publications in 2019HIGHLIGHTS
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GROUP LEADER VIDEO: MARC BÜHLER__
UPCOMING SEMINARS & EVENTS Due to the current coronavirus situation, all live seminars and events at the FMI have been cancelled or postponed. We will feature content in this section once we will have publicevents again.
More Publications __LATEST PUBLICATIONS
Nov 18, 2020
Monitoring Acetylation of the RNA Helicase DDX3X, a Protein Critical for Formation of Stress Granules. Saito M, Iestamantavicius V, Hess D, Matthias P__
Methods Mol Biol
Oct 15, 2020
Opposing Influence of Top-down and Bottom-up Input on Excitatory Layer 2/3 Neurons in Mouse Primary Visual Cortex.Jordan R, Keller GB
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Neuron
Oct 15, 2020
DNA Damage-Induced Nucleosome Depletion Enhances Homology Search Independently of Local Break Movement. Cheblal A, Challa K, Seeber A, Shimada K, Yoshida H, Ferreira HC,Amitai A, Gasser SM
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Mol Cell
Oct 7, 2020
Phenotypic landscape of intestinal organoid regeneration. Lukonin I, Serra D, Challet Meylan L, Volkmann K, Baaten J, Zhao R, Meeusen S, Colman K, Maurer F, Stadler MB, Jenkins J, Liberali P__
Nature
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