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SOFTWARE - ELVEFLOW

Software. The Elveflow Smart Interface allows an intuitive control of our microfluidic instruments in few clicks. It is thought both for basic control and complex tasks thanks to the use of the scheduler. The ESI Microfluidic Software makes easy many applications as: generation of continuous fluid streams, dosing of volumes, generation

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ELVEFLOW SOFTWARE & SDK The Elveflow Smart Interface allows an intuitive control of our microfluidic instruments in few clicks. It has been designed both for basic control and complex workflow and setups automation. The ESI Microfluidic Software makes easy many applications, such as: generation of continuous fluid streams, dosing of volumes, generation

of dynamic flow

MICROFLUIDIC FLOW RESTRICTORS Microfluidic Flow Restrictors : Inadequate resistance leads to poor flow control. Let’s take the example of a microfluidic chip with channels that are 500 µm wide, 70 µm high and 2 cm long. The fluidic resistance is quite small and implies an approximate pressure of 1 mbar for a flow rate of 5 µL/min. A user wanting to control the flow MICROFLUIDIC VALVE CONTROLLER & FLOW REDIRECTION This section will explain how to perform a flow redirection using the MUX Wire microfluidic valve controller, and 2 and 3 ways valves using the Elveflow® smart interface software. First make sure you have all the instruments you need, including the tubings and the microfluidic connectors. Mux Wire for control your microfluidic valves. MICROFLUIDIC TUBINGS AND SLEEVES: THE BASICS So, let’s start with some basic information about tubing and sleeves. Tubing allows you to link the multiple parts of your microfluidic setup: your fluid actuation device (a syringe pump, a peristaltic pump, an Elveflow AF1 or OB1 Pressure Controller) and the reservoirs, containers or sample chambers in which your liquids are

stored.

TROUBLESHOOT OB1 ISSUES : ELVEFLOW KNOWLEDGE BASE launch the software, add OB1 to the ESI, then turn on the vacuum and pressure sources. then put your sample. Then once it is finished, go back in ESI and set pressure at 0. remove the sample, block the pressure output of the OB1, turn off the vacuum and the pressure. THE BASICS OF MICROFLUIDIC FITTINGS, PLUGS & ADAPTERS The Basics of Microfluidic Fittings, Plugs & Connectors. Because they make setups more reliable, microfluidic accessories such as tubing, fittings and connectors are of fundamental importance. By enabling microfluidicists to free up more time to develop and test microfluidic strategies, microfluidic fittings can be an important factor for

success.

INSTALLATION INSTRUCTIONS : ELVEFLOW KNOWLEDGE BASE Installation instructions. Start here, to get a quick understanding about how to connect the elements from your pressure source to your flow sensor and set a flow control regulation. PEEK BUBBLE TRAP : ELVEFLOW KNOWLEDGE BASE Enter your search term here Search New support ticket MICROFLUIDIC INSTRUMENTS SPECIALIST Elveflow's developped a microfluidic resistance calculator dependent upon the microfluidic system from the flow rate, the device, the tubing to your fluid properties. The application note describes how to convert various units of viscosity from one to another: viscosity conversion from Poise, Pa.s, Dyn.s/cm²

SOFTWARE - ELVEFLOW

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INSTALLATION INSTRUCTIONS : ELVEFLOW KNOWLEDGE BASE Installation instructions. Start here, to get a quick understanding about how to connect the elements from your pressure source to your flow sensor and set a flow control regulation. PEEK BUBBLE TRAP : ELVEFLOW KNOWLEDGE BASE Enter your search term here Search New support ticket ELVEFLOW SOFTWARE & SDK The Elveflow Smart Interface allows an intuitive control of our microfluidic instruments in few clicks. It has been designed both for basic control and complex workflow and setups automation. The ESI Microfluidic Software makes easy many applications, such as: generation of continuous fluid streams, dosing of volumes, generation

of dynamic flow

PERFUSION CELL CULTURE & LIVE CELL IMAGING: METHODS I. Dynamic cell culture: WEBINAR. For more insight into methods and techniques to perform cell perfusion, please refer to this webinar introducing the concept of dynamic cell culture by incorporating perfusion, and describing the benefits of fluid flow, mechanical tension and shear stress to in vitro cell models of physiology and disease.. This webinar was performed by Lisa Muiznieks, research FLOW CHEMISTRY AND SAMPLE PREPARATION The advent of microfluidics as a tool for chemical synthesis is coming of age, particularly in industrial techniques. It has many advantages over conventional techniques such as as small reagent consumption, improved selectivity, less stringent reaction clean up, rapid reactions and small footprints. 3D MICROFLUIDIC MICROMIXER: ON-CHIP PARTICLE MANIPULATION This short review is based on the research paper “Innovative 3D Microfluidic Tools for On-Chip Fluids and Particles Manipulation: From Design to Experimental Validation”. It was authored by Sofia Zoupanou, Maria Serena Chiriacò, Iolena Tarantini and Francesco Ferrara.The study was published in the journal Micromachines on 21st

January, 2021.

MICROFLUIDIC CALCULATOR Microfluidic calculator. To help you choose the perfect instrument calibrated for your needs, Elveflow provides a microfluidic calculator. This will help you determine your flow rate, pressure to apply, the best tubing resistance length for your setup, wall shear

stress

INJECTION VALVE

The MUX Injection is a microfluidic bidirectionnal 6-port / 2-position valve. When paired with the OB1 MKIII+, it can perform stable and unidirectional fluid recirculation or precise injection of a controlled volume of sample. This versatile valve makes long-term experiments easier to automate and run. + Contact our experts. Contact

our experts.

MICROFLUIDIC VALVE CONTROLLER & FLOW REDIRECTION This section will explain how to perform a flow redirection using the MUX Wire microfluidic valve controller, and 2 and 3 ways valves using the Elveflow® smart interface software. First make sure you have all the instruments you need, including the tubings and the microfluidic connectors. Mux Wire for control your microfluidic valves. ELVEFLOW SMART INTERFACE contact@elveflow.com +33(0).184.163.807 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip.

HEART-ON-CHIP

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INSTALLATION INSTRUCTIONS : ELVEFLOW KNOWLEDGE BASE Installation instructions. Start here, to get a quick understanding about how to connect the elements from your pressure source to your flow sensor and set a flow control regulation. PEEK BUBBLE TRAP : ELVEFLOW KNOWLEDGE BASE Enter your search term here Search New support ticket ELVEFLOW SOFTWARE & SDK The Elveflow Smart Interface allows an intuitive control of our microfluidic instruments in few clicks. It has been designed both for basic control and complex workflow and setups automation. The ESI Microfluidic Software makes easy many applications, such as: generation of continuous fluid streams, dosing of volumes, generation

of dynamic flow

January, 2021.

stress

INJECTION VALVE

our experts.

HEART-ON-CHIP

microfabrication.

SOFTWARE - ELVEFLOW

contact@elveflow.com +33(0).184.163.807 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. ELVEFLOW SOFTWARE & SDK contact@elveflow.com +33(0).184.163.807 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. MICROFLUIDIC FLOW RESTRICTORS The flow rate in every fluidic system can be computed with the following equation: ∆P=Q×Rh Where: ∆P is the pressure difference between the inlet and the outlet of the system, Q is the flow rate throughout the system, Rh is the fluidic resistance of the system. MICROFLUIDIC TUBINGS AND SLEEVES: THE BASICS The Basics of Microfluidic Tubings and Sleeves. Microfluidic accessories, such as tubing, fittings and connectors are critical tools that strengthen experimental setups, making it possible to simplify and accelerate the discoveries of microfluidicists. MICROFLUIDIC VALVE CONTROLLER & FLOW REDIRECTION contact@elveflow.com +33(0).184.163.807 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. THE BASICS OF MICROFLUIDIC FITTINGS, PLUGS & ADAPTERS Microfluidicists have common requirements when it comes to their experimental setups. They need to connect the distinct components that make-up a setup, like pressure controllers, liquid tanks and reservoirs, flow switch matrices, etc Fittings and plugs play an important role in the increased security and reliability of microfluidic setups, allowing scientists to focus on their science and TROUBLESHOOT OB1 ISSUES : ELVEFLOW KNOWLEDGE BASE Elveflow’s OB1 troubleshooting guide. General Information. The purpose of this guide is to help any Elveflow user to troubleshoot, diagnose and resolve problems quickly but also provide as well our support team with a clear description of your situation, so that we can examine your case as efficiently as possible. INSTALLATION INSTRUCTIONS : ELVEFLOW KNOWLEDGE BASE Installation instructions. Start here, to get a quick understanding about how to connect the elements from your pressure source to your flow sensor and set a flow control regulation. PEEK BUBBLE TRAP : ELVEFLOW KNOWLEDGE BASE Enter your search term here Search New support ticket MICROFLUIDIC INSTRUMENTS SPECIALIST Microfluidics flow focusing. Hydrodynamic flow focusing is a powerful tool in the field of microfludics that can be used for numerous applications, such as microfluidic mixing, separations, sensors, cell analysis, flow cytometry, diffusion-controlled chemical reactions and

microfabrication.

SOFTWARE - ELVEFLOW

contact@elveflow.com +33(0).184.163.807 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. ELVEFLOW SOFTWARE & SDK contact@elveflow.com +33(0).184.163.807 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. MICROFLUIDIC FLOW RESTRICTORS The flow rate in every fluidic system can be computed with the following equation: ∆P=Q×Rh Where: ∆P is the pressure difference between the inlet and the outlet of the system, Q is the flow rate throughout the system, Rh is the fluidic resistance of the system. MICROFLUIDIC TUBINGS AND SLEEVES: THE BASICS The Basics of Microfluidic Tubings and Sleeves. Microfluidic accessories, such as tubing, fittings and connectors are critical tools that strengthen experimental setups, making it possible to simplify and accelerate the discoveries of microfluidicists. MICROFLUIDIC VALVE CONTROLLER & FLOW REDIRECTION contact@elveflow.com +33(0).184.163.807 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. THE BASICS OF MICROFLUIDIC FITTINGS, PLUGS & ADAPTERS Microfluidicists have common requirements when it comes to their experimental setups. They need to connect the distinct components that make-up a setup, like pressure controllers, liquid tanks and reservoirs, flow switch matrices, etc Fittings and plugs play an important role in the increased security and reliability of microfluidic setups, allowing scientists to focus on their science and TROUBLESHOOT OB1 ISSUES : ELVEFLOW KNOWLEDGE BASE Elveflow’s OB1 troubleshooting guide. General Information. The purpose of this guide is to help any Elveflow user to troubleshoot, diagnose and resolve problems quickly but also provide as well our support team with a clear description of your situation, so that we can examine your case as efficiently as possible. INSTALLATION INSTRUCTIONS : ELVEFLOW KNOWLEDGE BASE Installation instructions. Start here, to get a quick understanding about how to connect the elements from your pressure source to your flow sensor and set a flow control regulation. PEEK BUBBLE TRAP : ELVEFLOW KNOWLEDGE BASE Enter your search term here Search New support ticket ELVEFLOW SOFTWARE & SDK contact@elveflow.com +33(0).184.163.807 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. 3D MICROFLUIDIC MICROMIXER: ON-CHIP PARTICLE MANIPULATION This short review is based on the research paper “Innovative 3D Microfluidic Tools for On-Chip Fluids and Particles Manipulation: From Design to Experimental Validation”. It was authored by Sofia Zoupanou, Maria Serena Chiriacò, Iolena Tarantini and Francesco Ferrara.The study was published in the journal Micromachines on 21st

January, 2021.

PERFUSION CELL CULTURE & LIVE CELL IMAGING: METHODS I. Dynamic cell culture: WEBINAR. For more insight into methods and techniques to perform cell perfusion, please refer to this webinar introducing the concept of dynamic cell culture by incorporating perfusion, and describing the benefits of fluid flow, mechanical tension and shear stress to in vitro cell models of physiology and disease.. This webinar was performed by Lisa Muiznieks, research FLOW CHEMISTRY AND SAMPLE PREPARATION The advent of microfluidics as a tool for chemical synthesis is coming of age, particularly in industrial techniques. It has many advantages over conventional techniques such as as small reagent consumption, improved selectivity, less stringent reaction clean up, rapid reactions and small footprints. MICROFLUIDIC CALCULATOR To help you choose the perfect instrument calibrated for your needs, Elveflow provides a microfluidic calculator. This will help you determine your flow rate, pressure to apply, the best tubing resistance length for your setup, wall shear stress for biology applications, cell culture, and many more. MICROFLUIDIC VALVE CONTROLLER & FLOW REDIRECTION contact@elveflow.com +33(0).184.163.807 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. ELVEFLOW SMART INTERFACE contact@elveflow.com +33(0).184.163.807 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip.

INJECTION VALVE

Ideal microfluidic valve for precise sample injection and fluid recirculation. The MUX Injection is a microfluidic bidirectionnal 6-port / 2-position valve. When paired with the OB1 MKIII+, it can perform stable and unidirectional fluid recirculation or precise injection of a controlled volume of sample.

HEART-ON-CHIP

Heart-on-chip. Source : Kevin Parker, PhD, Harvard University. A heart-on-chip is a microfluidic chip reproducing the mechanisms of a heart, in order to test medicine quickly and observe the reaction of heart cells. Great care is given to mimic the mechanics of a LIST OF LEADING MICROFLUIDICS RESEARCH GROUPS Fujii microfluidics research group has been studying microfluidic devices and microfluidics since it was established in 1999. While the topics range from basic technologies to applied research, in recent years this lab put more and more intent on six research poles: MICROFLUIDIC INSTRUMENTS SPECIALIST Elveflow's developped a microfluidic resistance calculator dependent upon the microfluidic system from the flow rate, the device, the tubing to your fluid properties. The application note describes how to convert various units of viscosity from one to another: viscosity conversion from Poise, Pa.s, Dyn.s/cm² MICROFLUIDICS COMPANY ELVESYS GROUP PAGE Beta & innovation. Contact. contact@elveflow.com. +33 (0).184.163.807. Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. Pressure & vacuum control.

Microfluidic flow

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RESERVOIRS FOR MICROFLUIDICS EXPERIMENTATIONS Elveflow provides a wide range of autoclavable microfluidic adapters allowing to use them with different reservoir tubes (800uL, 1.5mL, 15mL, 50mL, 100mL and 150mL) in microfluidic systems using standard 1/4”-28 to 1/16" OD fittings interfaced with any pressure controller. The adapter are easily installable, autoclavable, and infinitely reusable. OB1 - 4 CHANNEL MICROFLUIDIC FLOW CONTROLLER - ELVEFLOW The OB1 allows you to control the output pressure of up to 4 channels independently, from -900 mbar to 8 bar, for a wide variety of advanced microfluidic applications . Thanks to our proprietary Piezoelectronic Technology, the OB1 MK3+ is 10 times more stable and up to DNA PROTECTION FROM MECHANICAL STRESS IN CELLS USING DNA protection from mechanical stress using microfluidics: a short review. In a 2020 Cell paper, Michele M. Nava and Yekaterina A. Miroshnikova, from Sara A. Wickström’s group in Helsinki, along with co-authors, demonstrate the ability of nucleus, cells and tissues to rapidly adapt to mechanical stress and avoid DNA damage. TROUBLESHOOT OB1 ISSUES : ELVEFLOW KNOWLEDGE BASE launch the software, add OB1 to the ESI, then turn on the vacuum and pressure sources. then put your sample. Then once it is finished, go back in ESI and set pressure at 0. remove the sample, block the pressure output of the OB1, turn off the vacuum and the pressure. MATERIALS FOR MICROFLUIDIC CHIPS FABRICATION : A REVIEW A microfluidic chip is a pattern of microchannels molded or engraved. Output holes are built through the chip and serve as links between the microchannels network and the macro-environment. Presenting sometimes valves for active flow control, microfluidic chips can MICROFLUIDIC INSTRUMENTS SPECIALIST Elveflow's developped a microfluidic resistance calculator dependent upon the microfluidic system from the flow rate, the device, the tubing to your fluid properties. The application note describes how to convert various units of viscosity from one to another: viscosity conversion from Poise, Pa.s, Dyn.s/cm² MICROFLUIDICS COMPANY ELVESYS GROUP PAGE Beta & innovation. Contact. contact@elveflow.com. +33 (0).184.163.807. Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. Pressure & vacuum control.

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3D MICROFLUIDIC MICROMIXER: ON-CHIP PARTICLE MANIPULATION This short review is based on the research paper “Innovative 3D Microfluidic Tools for On-Chip Fluids and Particles Manipulation: From Design to Experimental Validation”. It was authored by Sofia Zoupanou, Maria Serena Chiriacò, Iolena Tarantini and Francesco Ferrara.The study was published in the journal Micromachines on 21st

January, 2021.

stress

ELVEFLOW - A METHOD TO DYNAMICALLY SCREEN AND PRINT SINGLE This short review article is based on the research paper titled “The method to dynamically screen and print single cells using microfluidics with pneumatic microvalves”, authored by Chang Chen, Yonggang Zhu, Joshua W.K. Ho and Huaying Chen. The research paper was published in The MethodsX. Journal in December, 2020. HOW TO STAIN CELLS CULTURED IN A MICROFLUIDIC CHIP? Forces are abundant on cells and tissues in the body but are largely absent from traditional cell culture setups, which are static. Microfluidic platforms enable the controlled addition of fluid flow and mechanical stress to cells grown in vitro.A dynamic culture environment promotes the continuous transport of nutrients, metabolites and waste, as well as the addition of shear stress, an WHY AND HOW TO USE A MICROFLUIDIC BUBBLE TRAP? This bubble trap can be used with or without vacuum assistance, and a vacuum source such as the OB1 Mk3 can be connected to maximize the bubble trap’s efficiency. This trap is typically used in the range of 0.5 – 2.0 ml/min, but up to 60ml/min can be achieved when a vacuum line is used. The following video shows the in line bubble

removing

LUNG-ON-A-CHIP: HISTORY, ORIGINS AND DEVELOPMENT Lung-on-a-Chip: History, Origins and Development. 1. Introduction into the history of lung-on-a-chip microfluidic systems. The human lungs serve the vital purpose of gas exchange in the respiratory system. Their sponge-like structure serves to maximize the useful surface area in the form of alveoli subunits, where an air-liquid interface (ALI MICROFLUIDICS FOR POINT-OF-CARE DIAGNOSTIC DEVICES: A Microfluidics for POC biosensors and diagnostics has proven to be an effective way of reducing the size, weight, cost, and assay time of infectious pathogens detection techniques. Combined with nanoparticles, those devices show an enhanced sensitivity compared

with

MICROFLUIDIC INSTRUMENTS SPECIALIST Elveflow's developped a microfluidic resistance calculator dependent upon the microfluidic system from the flow rate, the device, the tubing to your fluid properties. The application note describes how to convert various units of viscosity from one to another: viscosity conversion from Poise, Pa.s, Dyn.s/cm² MICROFLUIDICS COMPANY ELVESYS GROUP PAGE Beta & innovation. Contact. contact@elveflow.com. +33 (0).184.163.807. Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. Pressure & vacuum control.

Microfluidic flow

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MICROFLUIDIC TUBINGS AND SLEEVES: THE BASICS So, let’s start with some basic information about tubing and sleeves. Tubing allows you to link the multiple parts of your microfluidic setup: your fluid actuation device (a syringe pump, a peristaltic pump, an Elveflow AF1 or OB1 Pressure Controller) and the reservoirs, containers or sample chambers in which your liquids are

stored.

OB1 - 4 CHANNEL MICROFLUIDIC FLOW CONTROLLER - ELVEFLOW The OB1 allows you to control the output pressure of up to 4 channels independently, from -900 mbar to 8 bar, for a wide variety of advanced microfluidic applications . Thanks to our proprietary Piezoelectronic Technology, the OB1 MK3+ is 10 times more stable and up to WHY AND HOW TO USE A MICROFLUIDIC BUBBLE TRAP? This bubble trap can be used with or without vacuum assistance, and a vacuum source such as the OB1 Mk3 can be connected to maximize the bubble trap’s efficiency. This trap is typically used in the range of 0.5 – 2.0 ml/min, but up to 60ml/min can be achieved when a vacuum line is used. The following video shows the in line bubble

removing

THE BASICS OF MICROFLUIDIC FITTINGS, PLUGS & ADAPTERS The Basics of Microfluidic Fittings, Plugs & Connectors. Because they make setups more reliable, microfluidic accessories such as tubing, fittings and connectors are of fundamental importance. By enabling microfluidicists to free up more time to develop and test microfluidic strategies, microfluidic fittings can be an important factor for

success.

MICROFLUIDIC FOR FUNGUS IDENTIFICATION AND RESEARCH: A Owning to the limitations posed by the conventional techniques for identification of fungi (only focused on the detection and identification of fungi by morphological characteristics) with the rapid development of microimaging technology and microfluidic chips, it becomes possible to observe the germination and growth of fungi in

real-time.

TROUBLESHOOT OB1 ISSUES : ELVEFLOW KNOWLEDGE BASE launch the software, add OB1 to the ESI, then turn on the vacuum and pressure sources. then put your sample. Then once it is finished, go back in ESI and set pressure at 0. remove the sample, block the pressure output of the OB1, turn off the vacuum and the pressure. MICROFLUIDIC INSTRUMENTS SPECIALIST Elveflow's developped a microfluidic resistance calculator dependent upon the microfluidic system from the flow rate, the device, the tubing to your fluid properties. The application note describes how to convert various units of viscosity from one to another: viscosity conversion from Poise, Pa.s, Dyn.s/cm² MICROFLUIDICS COMPANY ELVESYS GROUP PAGE Beta & innovation. Contact. contact@elveflow.com. +33 (0).184.163.807. Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip. Pressure & vacuum control.

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MICROFLUIDIC RESISTANCE CALCULATOR In the advice section, the calculator recommends to add microfluidic resistance to have a higher pressure to apply and a more stable flow. Different inner diameter values are proposed and the related length of it to achieve 100 mBar. Here, we will use a 250 um ID (Inner Diameter) with 8 cm before the chip.

HEART-ON-CHIP

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ORGAN-ON-CHIP COMPANIES Mimetas – the organ-on-chip company is a Dutch company known for developing OrganoPlates, microfluidic cell culture plates that allow culture and screening of a large assay of organ models and physiologically relevant tissues. Thanks to those plates, Mimetas has already developed many organs-on-chips (kidney, gut, tumors and many

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PDMS: A REVIEW

Polydimethylsiloxane, called PDMS or dimethicone, is a polymer widely used for the fabrication and prototyping of microfluidic chips.

reviews

MATERIALS FOR MICROFLUIDIC CHIPS FABRICATION : A REVIEW 2017 Microfluidics involve different types of devices, and materials for microfluidic fabrication must be selected while bearing in mind all the requirements necessary for building a fine microfluidic device.

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INTRODUCTION TO LAB-ON-A-CHIP 2015 : REVIEW, HISTORY AND FUTURE A lab-on-a-chip is a miniaturized device that integrates onto a single chip one or several analyses, which are usually done in a laboratory; analyses such as DNA sequencing or biochemical detection.

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MICROFLUIDIC PCR & QPCR In this review, we will present the PCR, qPCR and other associated methods with their microfluidic applications.

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MICROFLUIDICS APPLICATIONS: A SHORT REVIEW Microfluidics is a term which appears more and more often in papers and scientific magazines; but, what exactly is microfluidics?

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AIR BUBBLES AND MICROFLUIDICS Air bubbles are among the most recurring issues in microfluidics. Because of the micrometric dimensions of the tubes and channels

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INTRODUCTION ABOUT SOFT-LITHOGRAPHY FOR MICROFLUIDICS Unlike photolithography, soft lithography can process a wide range of elastomeric materials, i.e. mechanically soft materials.

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MICROFLUIDICS AND MICROFLUIDIC DEVICES : A REVIEW Microfluidics is the science that deals with the flow of liquid inside micrometer-size channels.

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THE BASICS OF MICROFLUIDIC TUBING & SLEEVES Microfluidic accessories, such as tubing, fittings and connectors are critical tools that strengthen experimental setups, making it possible to simplify and accelerate the discoveries of microfluidicists.

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3D CELL CULTURE METHODS AND APPLICATIONS – A SHORT REVIEW Cell culture consists in growing cells in an artificial environment in order to study their behavior in response to their environment. Different kinds of cell cultures can be found nowadays, and some would be more suited than others depending on its properties and

applications.

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FLOW CONTROL IN MICROFLUIDICS DEVICE There are three main classes of systems to control liquid motion in microfluidic and nanofluidic devices.

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MICROFLUIDIC MIXERS : A SHORT REVIEW In microfluidic laminar flows, traditional turbulent mixing between two liquids cannot occur. However, controllable and fast mixing is critical for microfluidic and lab-on-chip devices. So different mixing techniques were developed and are here presented.

reviews

DROPLET-SEQUENCING (DROP-SEQ) Drop-Seq is a strategy based on the use of microfluidics for quickly profiling thousands of individual cells simultaneously by encapsulating them in tiny droplets for parallel analysis. This review presents the techniques and applications of Drop-Seq.

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MICROFLUIDICS: A GENERAL OVERVIEW OF MICROFLUIDICS Microfluidics is both the science which studies the behaviour of fluids through micro-channels and the technology of manufacturing microminiaturized devices containing chambers and tunnels through which fluids flow or are confined.

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PDMS: A REVIEW

Polydimethylsiloxane, called PDMS or dimethicone, is a polymer widely used for the fabrication and prototyping of microfluidic chips.

reviews

MICROFLUIDIC PCR & QPCR In this review, we will present the PCR, qPCR and other associated methods with their microfluidic applications.

*

reviews

MICROFLUIDICS APPLICATIONS: A SHORT REVIEW Microfluidics is a term which appears more and more often in papers and scientific magazines; but, what exactly is microfluidics?

reviews

AIR BUBBLES AND MICROFLUIDICS Air bubbles are among the most recurring issues in microfluidics. Because of the micrometric dimensions of the tubes and channels

reviews

INTRODUCTION ABOUT SOFT-LITHOGRAPHY FOR MICROFLUIDICS Unlike photolithography, soft lithography can process a wide range of elastomeric materials, i.e. mechanically soft materials.

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Microfluidic reviews

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MICROFLUIDIC REVIEWS

113 articles

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MICROFLUIDICS AND MICROFLUIDIC DEVICES : A REVIEW Microfluidics is the science that deals with the flow of liquid inside micrometer-size channels.

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applications.

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FLOW CONTROL IN MICROFLUIDICS DEVICE There are three main classes of systems to control liquid motion in microfluidic and nanofluidic devices.

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MICROFLUIDICS INVESTIGATION OF FOAM HYSTERESIS Foam stability often describes the foam left to evolve with time in static conditions. Nevertheless, in everyday life, foams are subjected to a number of deformations. A feature of foam stability is represented by the foam’s ability to resist to the deformation and to recover its initial properties after deformation.

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MULTICOMPONENT LASER PRINTING Thus far, 3D laser-micro and nanoprinting offered a widespread alternative to prepare complex but single constituent 3D microfluidic structure. This work proposes a system based on a microfluidic chamber integrated into a state-of-the-art laser lithography apparatus that allows the use of several materials to 3D print complex structures in the most effective manner.

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MICROGEL GENERATION AND ENCAPSULATION IN MICRODROPLETS PEGDA (poly (ethylene glycol) diacrylate) microgels were generated and encapsulated within pico-droplets by combining droplet-based microfluidics and microscope projection photolithography. A continuous-flow photolithography was set up within a cross junction to generate and simultaneously to in-situ encapsulate fiber-like structures in pico-droplets.

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Microfluidic reviews

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Microfluidic reviews

113 reviews

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applications.

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FLOW CONTROL IN MICROFLUIDICS DEVICE There are three main classes of systems to control liquid motion in microfluidic and nanofluidic devices.

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PDMS: A REVIEW

Polydimethylsiloxane, called PDMS or dimethicone, is a polymer widely used for the fabrication and prototyping of microfluidic chips.

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MICROFLUIDIC PCR & QPCR In this review, we will present the PCR, qPCR and other associated methods with their microfluidic applications.

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MICROFLUIDICS APPLICATIONS: A SHORT REVIEW Microfluidics is a term which appears more and more often in papers and scientific magazines; but, what exactly is microfluidics?

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AIR BUBBLES AND MICROFLUIDICS Air bubbles are among the most recurring issues in microfluidics. Because of the micrometric dimensions of the tubes and channels

reviews

INTRODUCTION ABOUT SOFT-LITHOGRAPHY FOR MICROFLUIDICS Unlike photolithography, soft lithography can process a wide range of elastomeric materials, i.e. mechanically soft materials.

*

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PDMS MEMBRANE: THICKNESS OF A SPIN COATED PDMS LAYER The final PDMS layer thickness mainly depends of spin-coating speed

and duration.

reviews

SYRINGE PUMP RESPONSIVENESS AND MICROFLUIDIC RESEARCH Syringe pumps are widely used in microfluidics research since they are easy to use and enable fast setup of microfluidic experiments. The two main drawbacks of syringe pumps in MICROFLUIDICS are the slow response time when setting a new flow rate and the FLOW OSCILLATIONS DUE TO MOTOR STEPS. Here, we will focus on understanding why syringe pumps have low responsiveness in microfluidics and go through ways to address this concern.

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MICROFLUIDIC FLOW CONTROL: SHORT REVIEW ABOUT CELLIX EXIGO SYRINGE

PUMP

Outside of conventional syringe pumps which generate flow oscillation at low flow rate we can now find syringe pump dedicated to microfluidic experiment.

reviews

A REVIEW ABOUT ORGAN ON CHIP Organs on chips are microengineered biomimetic systems that replicate key functions of living organs. They provide a more accurate model than conventional cell culture for simulating complex cell-cell and cell-matrix interactions.

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INTRODUCTION TO POLY-DI-METHYL-SILOXANE (PDMS) Polydimethylsiloxane, called PDMS or dimethicone, is a polymer widely used for the fabrication and prototyping of microfluidic chips. It is a mineral-organic polymer (a structure containing carbon and silicon)

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HOW TO CHOOSE A MICROFLUIDIC TUBING ? Several parameters have to be taken into consideration while choosing a microfluidic tubing. Depending on your application, the choice of the right tubing for

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WHY AND HOW TO USE A MICROFLUIDIC BUBBLE TRAP? Gas bubbles present in a liquid sample are a common problem encountered in numerous microfluidic experiments, and their removal in the sample of interest is quite often a major challenge for

microfluidicists.

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HISTORY OF MICROFLUIDICS Today, MICROFLUIDICS is a distinct and major technological field, but 20 years ago it was not like this and its boundaries were not so well defined. The history of microfluidics is strictly related to several

other areas

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LIQUID FOAM TEMPLATING In an article published by sébastien andrieux, wiebke drenckhan, cosima stubenrauch in the journal "polymer", the authors show that microfluidics liquid foam templating can be used to produce biobased highly monodisperse chitosan foams. the demonstrated system employs a fine and smooth control of the two-phase flow rates to accurately tune the bubble size generation, with diameters ranging from 200 to 800 �m. solid chitosan foams can be obtained by freeze-drying the resulting highly ordered chitosan liquid foams.

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A SHORT REVIEW ON MONODISPERSE DOUBLE EMULSION IN MICROFLUIDIC CHIPS Multiple emulsions (monodisperse double emulsions for example) are promising materials for industrial fields like cosmetics, pharmaceutics or food. These emulsions in an emulsion can be used to encapsulate fragile compounds (drugs, vitamins, aromas…),

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HOW TO CHOOSE THE RIGHT MICROFLUIDIC FLOW CONTROL SYSTEM? What are the strengths and weaknesses of each type of microfluidic flow control system? Pressure controller, syringe pump...?

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MICROFLUIDIC LOW-FLOW LIQUID FLOW METERS : A REVIEW Liquid flow sensors are a compulsory element of microfluidic systems requiring a control of the sample volume dispensed and/or, obviously, the sample flow rate.

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STABILITY OF MICROFLUIDIC FLOW CONTROL INSTRUMENT The performance of your flow control instruments depends on your experimental conditions.

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TRICKS AND TIPS TO ENHANCE YOUR MICROFLUIDIC FLOW CONTROL Despite their sturdiness & simplicity, syringe pumps are often problematic in microfluidics.

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RESPONSIVENESS OF FLOW CONTROL INSTRUMENTS Microfluidic flow controllers are designed to control flows in

microfluidic chips.

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RESEARCHERS’ OPINION ON FLOW CONTROL FOR MICROFLUIDICS One of the great challenges for researchers using microfluidics is miniaturizing analysis processes in very small microchip.

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MAGNETIC FLUIDS AND MICROFLUIDICS: A SHORT REVIEW Magnetic manipulation of micro-fluids is an attractive concept. Due to the non-invasive nature of magnetic fields, magnetic particles or magnetic fluids can be manipulated inside a microfluidic channel by external magnets that are not in direct contact with the fluid.

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MAGNETIC PARTICLE SEPARATION : A SHORT REVIEW This review presents a few examples of applications where magnetic flux sources, magnetic particles and microfluidics are combined in order to perform particle sorting and handling.

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SYRINGE PUMPS AND MICROFLUIDICS In the past two years, several new microfluidic syringe pump systems have changed the use of syringe pumps in microfluidic experiments.

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GENERATE DROPLETS IN MICROFLUIDIC CAPILLARY We focus here on how to make droplets with commercial tools, especially chromatography tools like cross or a T junctions.

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RESEARCHERS’ OPINION ON DROPLET GENERATION IN MICROFLUIDICS: SYRINGE PUMPS OR PRESSURE CONTROL? Droplet generation in microfluidic, the aim of this technology is to create fluid-fluid dispersion into channels

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WHAT IS DIGITAL MICROFLUIDICS? Digital microfluidics is an alternative technology for microfluidic systems based on the design, composition and manipulation of discrete droplets and/or bubbles.

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DIGITAL MICROFLUIDICS: MICROFLUIDIC DROPLET AND EMULSION SCIENCE Microfluidic technologies offer an efficient means of producing highly uniform droplets and bubbles, and also a convenient mechanism for manipulating their downstream motion.

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DROPLET DETECTION AND MEASUREMENT IN MICROFLUIDIC CHANNELS The biggest advantage of droplet-based microfluidics over other droplet-based systems is the uniformity or monodispersity of the

droplets.

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DIGITAL MICROFLUIDICS USING PRESSURE DRIVEN FLOW Making droplets in a capillary or a microfluidic device is often met

with two problems

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PDMS QUAKE VALVES AND CO : A REVIEW PDMS pneumatic microvalves are based on the pressure-driven deformation of a soft material (generally PDMS) that clogs or releases liquid flows into microsystems.

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MICROFLUIDIC NANOPARTICLE SYNTHESIS: A SHORT REVIEW Nanoparticles are particles with a size smaller than 100 nm. They are made up of carbon, metal, metal oxides or organic matter.

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OPTICAL DETECTION TECHNIQUES FOR MICROFLUIDICS Suitable detection techniques are required to be coupled to microfluidic technology in order to analyze experiment outcomes in a sensitive and scalable way.

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MICROFLUIDICS AS A TOOL FOR DRUG DELIVERY Microfluidics, i.e. the science and engineering of fluid flows in microscale, can be the answer for a more effective and targeted drug

administration.

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MICROFLUIDICS FOR DNA ANALYSIS This review presents the main applications of microfluidics for molecular analysis and its numerous techniques for DNA analysis.

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SOFT ROBOT – A REVIEW Soft robotics is a growing field which relies on mimicking locomotion mechanisms of soft bodies existing in nature to achieve smooth and complex motion. This review presents the different techniques and applications of soft robotics.

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MICROREACTORS & MICROFLUIDICS IN CHEMISTRY – A REVIEW This review introduces the field of microfluidics and provides an overview of the advantages, disadvantages, and current applications of microfluidics in chemistry.

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ELECTROCHEMISTRY AND MICROFLUIDICS : A SHORT REVIEW Electrochemical detection is particularly suitable for lab-on-a-chip integration and microfluidics due to the versatility of size, geometry and nature of electrodes that can be integrated within a microfluidic platform, and to the minimum instrumentation it requires.

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PAPER MICROFLUIDIC DEVICES : A REVIEW 2017 Diagnosis is the first step in treating any disease, and paper microfluidic devices can facilitate this crucial step. Most of the time, this necessary task is

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MICRORHEOLOGY – A REVIEW Microrheology is a technique used to measure the rheological properties of a medium, such as viscosity and viscoelasticity. This short review is presenting the different techniques and applications.

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PDMS SOFTLITHOGRAPHY Here you can find a complete overview of a PDMS chip replication.

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SU-8 MOLD LITHOGRAPHY Here you can find a complete overview of a SU-8 mold fabrication

process.

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SU-8 PHOTOLITHOGRAPHY: SPIN-COATING How do you perform a successful spin coating? Here you will find the tips and tricks to do it.

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SU-8 PHOTOLITHOGRAPHY: BAKING How do you perform a successful photoresist baking? Here you will find the tips and tricks to do it.

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SU-8 PHOTOLITHOGRAPHY: UV EXPOSURE How do you perform a successful SU-8 exposure? Here you will find the tips and tricks to do it.

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SOFT LITHOGRAPHY: SU-8 BAKING Replicating PDMS-based structures first requires the fabrication of a SU-8 master mold that will serve as a patterned template for PDMS

casting

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SOFT LITHOGRAPHY SU-8 COATING In soft lithography, the fabrication of a mold, often made in SU-8, is required for replicating PDMS microfluidic structures.

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ORGANS ON CHIPS

Since 2012, more and more people, companies or lab, have worked on the organs-on-chips. These cell cultures can, thanks to microfluidics, mimic the cells microenvironment of the human body. Thus, these chips could become wonderful search accelerators and we can hope that, in ten years, they could replace the animal testing. Finally, organs on chips could lead us to personalized medicine.

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ORGANS ON CHIP REVIEW Multi-organs on chip could also allow us to witness the side effects of certain drugs on different organs, not limited to those that the

treatment targets.

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COMPARISON BETWEEN ORGAN-ON-CHIP AND STANDARD IN VITRO AND IN VIVO SYSTEMS FOR DRUG TESTING In vitro and in vivo models are widely used to investigate human pathophysiology as well as in toxicology studies. The goal of this review is to highlight the main advantages and limitations of each model and to show how the use of organ-on-chip technology can address

their drawbacks.

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MICROFLUIDIC TUMOR-ON-CHIP SYSTEMS FOR BREAST CANCER RESEARCH Breast cancer is one of the most frequent malignant tumors among women worldwide. In the early stage of breast cancer, neoplastic epithelial cells accumulate in the lumen of mammary duct that form pre-invasive cancerous lesions known as ductal carcinoma in situ (DCIS).

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RECENT RESEARCH BREAKTHROUGHS IN LUNG-ON-CHIP TECHNOLOGY It could be extremely interesting to build a human-on-chip that will model the interactions between different organs, but it is also essential to develop simulations of tissue-tissue interfaces and more generally of local organ behavior.

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AIR-LIQUID INTERFACE AND OPTIMIZED CELL CULTURE SUBSTRATE FOR A MICROFLUIDIC LUNG-ON-CHIP APPLICATION The lung is the main organ of respiration whose function is to facilitate gas exchange in and out of the blood stream.

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A SHORT OVERVIEW OF LUNG-ON-CHIP SYSTEMS – THE USE OF THE ALVEOLAR-CAPILLARY BARRIER IN HUMAN MEDICINE Organ-on-chip technology provides unique opportunities to study lung physiology and pathophysiology in vitro.

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LUNG-ON-A-CHIP: HISTORY, ORIGINS AND DEVELOPMENT While many animal models have been used to study lung diseases, they lack sufficient similarity with human systems, leaving gaps in what is possible in animal-based platforms.

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GUT-ON-CHIP: KEEPING UP WITH THE TECHNOLOGY The gut fulfills a lot of important bodily functions, especially concerning the transport and oral absorption of drugs and nutrients, one of the key phases in pharmacokinetics.

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HEART-ON-CHIP

A heart-on-chip is a microfluidic chip reproducing the mechanisms of a heart, in order to test medicine quickly and observe the reaction of heart cells. Great care is given to mimic the mechanics of a heart in an artificial structure, lined with live heart cells.

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LIVER-ON-CHIP: KEEPING UP WITH THE TECHNOLOGY The liver is involved in more than 300 vital functions, but is mainly known for being part of the digestive tract, where it has the extremely important role of metabolizing both xenobiotics and nutrients (carbohydrates and lipids).

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MICROFLUIDIC “MINI-BRAINS”: KEEPING UP WITH THE BRAIN-ON-CHIP

TECHNOLOGY

At the beginning of the third millennium, due to prolonged aging, neurodevelopmental disorders are growing and a much deeper understanding of the brain is necessary.

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3D CELL CULTURE: MARKET AND INDUSTRIAL NEEDS In this report, we identify the following two main purposes for the 3D

cell market

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MICROFLUIDIC FOR CELL BIOLOGY: CONCEPTS AND METHODOLOGIES We review here the basic concepts and methodologies in designing microfluidic devices, and their diverse cell biological applications.

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IMPEDANCE-BASED VISCOELASTIC FLOW CYTOMETRY Flow cytometry microfluidics employs the elastic property of viscoelastic ﬂuids to induce lateral lift force to migrate the particles into a single streamline.

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INTRODUCTION TO DROPLET-BASED MICROFLUIDICS Droplets formed within microfluidic channels often serve as microreactors containing different chemical or biological compounds, allowing massive numbers of independent reactions to be performed rapidly using a minimal amount of total reagent.

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MICROFLUIDIC CONTROL OVER NEMATIC LIQUID CRYSTAL FLOWS Orientational order of nematic liquid crystals (NLCs), unlike isotropic liquids, enhances the influence of their rheological properties, and thus requires precise tuning of the flow parameters to control the orientational patterns.

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CORONAVIRUS (SARS-COV2) DIAGNOSTIC WITH MICROFLUIDICS Coronavirus (SARS-Cov2) diagnostic through microfluidics

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MICROFLUIDIC FABRICATION OF NANOHYDROGELS FOR DRUG-DELIVERY The authors describe the use of microfluidics for the fabrication of nanohydrogels made from hyaluronic acid derivatives, for

drug-delivery.

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ACOUSTIC TECHNIQUES FOR MICROFLUIDIC PARTICLE SORTING Acoustic techniques for sorting and separation of micron-sized particles in microfluidic devices

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MICROFLUIDIC FLOW CONTROL : SHORT REVIEW ABOUT NEW ERA NE-1002-X

SYRINGE PUMP

Outside of conventional syringe pumps which generate flow oscillation at low flow rate and long settling time, we can now find syringe pumps dedicated to microfluidic experiments.

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HOW TO CHOOSE A MICROFLUIDIC FITTING OR CONNECTOR ? It is no secret that in MICROFLUIDICS as in other fields, sometimes the smallest things can make the biggest difference. We all have better things to do than waste our precious time dealing with leakage

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PULSELESS SYRINGE PUMPS FOR MICROFLUIDICS Common syringe pumps have two major drawbacks when it comes to research in MICROFLUIDICS: RESPONSIVENESS and flow OSCILLATION/PULSATILE FLOW. Recently, some syringe pump manufacturers

have developed...

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SHORT REVIEW ABOUT HARVARD APPARATUS PHD ULTRA ADVANCED SYRINGE PUMP Since 1956, Harvard Apparatus offers a broad range of syringe and peristaltic pumps to suit almost every fluidic application. Harvard Apparatus Phd's ultra advanced syringe pump is designed for micro and nanofluidic applications.

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INTRODUCING THE REVIEW OF THE KD SCIENTIFIC LEGATO 180 PICOLITER

SYRINGE PUMP

KD Scientific designs, manufactures and sells a range of quality fluidics equipment and evaporators used by research laboratory markets worldwide. The KD Scientific Legato 180 Picoliter Syringe Pump is designed for micro and nanofluidic applications.

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THE BASICS OF MICROFLUIDIC FITTINGS, PLUGS & ADAPTERS Because they make setups more reliable, microfluidic accessories such as tubing, fittings and connectors are of fundamental importance. By enabling microfluidicists to free up more time to develop and test microfluidic strategies,

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SHORT REVIEW ABOUT HARVARD APPARATUS11 PICO PLUS ELITE SYRINGE PUMP Since 1956, Harvard Apparatus offers a broad range of syringe and peristaltic pumps to suit almost every fluidic application.

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INTRODUCTION ABOUT PHOTOMASK IN MICROFLUIDICS A photolithography mask is an opaque plate or film with transparent areas that allow light to shine through a defined pattern

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SOFT-LITHOGRAPHY DEFINITIONS When you talk about microfluidics, some words can be new, we gathered here some common and relevant definitions

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MICROFLUIDIC FABRICATION TECHNICS There are different techniques to make microfluidic devices. The main ones are etching, thermoforming, polymer ablation and polymer casting

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INFLUENCE OF YOUR MICROFLUIDIC LABORATORY ENVIRONMENTAL PARAMETERS ON

YOUR PHOTOMASK

Environmental and mechanical conditions can affect the overall size of the photolithographic mask considerably when it is polyester film-made, and to a lesser degree when it is glass-made.

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MICROFLUIDIC FOUNDRIES If you don’t fabricate your microfluidic device yourself, it is important to choose the right microfluidic company to fabricate your

microfluidic chip.

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FABRICATION OF GLASS AND FILM PHOTOMASKS The photolithography mask is an important tool in soft photolithography processes, we explain here how they are made

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SOFT LITHOGRAPHY: GLASS/PDMS BONDING How do you perform a successful PDMS bonding with a plasma cleaner? Here you will find the tips and tricks to do it.

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MICROFLUIDIC 3D PRINTER Every following technology is based on the same system of additive process, every object is built layer by layer after being sliced by an

informatic system.

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SU-8 PHOTOLITHOGRAPHY : HOT PLATES A hot plate to bake your SU-8 photoresist, you will find here the relevant points to think about.

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SU-8 PHOTOLITHOGRAPHY: PHOTOMASK You have the choice between glass or plastic photolithography mask, but how do you choose? here is some information to help you with the

decision

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SU-8 PHOTOLITHOGRAPHY : SPIN COATER A spin coater creates a thin layer of photoresist or PDMS, you will find here the relevant information about how to choose one.

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PDMS SOFT LITHOGRAPHY : PLASMA CLEANER A plasma cleaner to bond your PDMS chip, you will find here the relevant points to think about.

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SU-8 PHOTOLITHOGRAPHY : UV SOURCES A UV Lamp to expose your SU-8 photoresist. You will find here the relevant points to think about.

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ANTI-AGING RESEARCH, MICROFLUIDICS AND ORGANS-ON-CHIPS Although we take part in various research projects such as artificial photosynthesis, pathogen detection and stem cell differentiation, the ultimate goal of our entrepreneurial adventure is to accelerate anti-aging research.

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ORGAN-ON-CHIP: THE COMPANIES Companies researching organs-on-chip

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GRADIENTS GENERATION FOR CELL BIOLOGY IN MICROFLUIDICS Chemical gradients play a key role in many biological processes and regulate a number of cellular functions in vivo. Indeed, there are several examples of gradient-dependent phenomena in nature.

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LABEL-FREE MICROFLUIDIC CELL SEPARATION AND SORTING TECHNIQUES: A

REVIEW

In this review we will describe some label-free microfluidic techniques to accomplish cell separation and sorting.

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CELL DEFORMATION USING MICROFLUIDIC CHIP Cells growth, gene expression and differentiation are often related to mechanical environment such as confinement or applied stresses.

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A REVIEW OF HEATING AND TEMPERATURE CONTROL IN MICROFLUIDIC SYSTEMS: TECHNIQUES AND APPLICATIONS This review presents an overview of the different techniques developed over the last decade to regulate the temperature within microfluidic

systems.

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PERFUSION FOR LIVE CELL IMAGING: METHODS AND SYSTEMS Live-cell imaging is a non destructive method which focuses on the observation of live cells and is widely used in cellular biology research and biomedical industry. This short review will present some technical aspects and challenges encounter in this field.

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PERFUSION FOR LIVE-CELL IMAGING: A REVIEW Live-cell imaging is a non destructive method which focuses on the observation of live cells and is widely used in cellular biology research and biomedical industry. This short review will present some technical aspects and challenges encountered in this field. Nowadays, the most widely used cell culture system is the static culture, where the cells are cultivated inside Petri dishes or multiwall plates. In static culture, the culture medium is supplied in a batch-wised

manner.

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IMAGING AND MICROSCOPY: PERFUSION CHAMBERS The first live-cell imaging chambers were designed in the early twentieth century, shortly after mammalian cell culture techniques

were developped

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PERFUSION FOR LIVE CELL IMAGING: METHODS AND TECHNIQUES Live-cell imaging is a method which focuses on the observation of live cells and is widely used in cellular biology research and biomedical

industry.

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MICROFLUIDIC CELL CULTURE: MEDIUM CHANGE Ability to switch drugs in seconds or less in microfluidic chips allows studying cell response at cells timescale.

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PH MONITORING IN MICROFLUIDICS: A SHORT REVIEW The ultimate goal in microfluidics is to achieve the so-called laboratory-on-a-chip, i.e. integrate all those activities which are usually performed in a laboratory within a single microfluidic chip

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PDMS IN BIOLOGY RESEARCHES: A CRITICAL REVIEW ON PDMS LITHOGRAPHY FOR

BIOLOGICAL STUDIES

PDMS advantages and drawbacks for cell biology are here discussed.

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C. ELEGANS IMMOBILIZATION VIA MICROFLUIDICS: A SHORT REVIEW Caenorhabditis elegans, commonly shortened as C. elegans, is a non-parasitic nematode which, for its peculiar proprieties, is widely used as a model organism in biology.

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Microfluidic reviews

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Microfluidic reviews

113 reviews

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applications.

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FLOW CONTROL IN MICROFLUIDICS DEVICE There are three main classes of systems to control liquid motion in microfluidic and nanofluidic devices.

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*

Show all

Microfluidic reviews

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Microfluidic reviews

113 *

reviews

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applications.

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FLOW CONTROL IN MICROFLUIDICS DEVICE There are three main classes of systems to control liquid motion in microfluidic and nanofluidic devices.

*

reviews

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PDMS: A REVIEW

Polydimethylsiloxane, called PDMS or dimethicone, is a polymer widely used for the fabrication and prototyping of microfluidic chips.

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MICROFLUIDIC PCR & QPCR In this review, we will present the PCR, qPCR and other associated methods with their microfluidic applications.

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MICROFLUIDICS APPLICATIONS: A SHORT REVIEW Microfluidics is a term which appears more and more often in papers and scientific magazines; but, what exactly is microfluidics?

*

reviews

AIR BUBBLES AND MICROFLUIDICS Air bubbles are among the most recurring issues in microfluidics. Because of the micrometric dimensions of the tubes and channels

*

reviews

INTRODUCTION ABOUT SOFT-LITHOGRAPHY FOR MICROFLUIDICS Unlike photolithography, soft lithography can process a wide range of elastomeric materials, i.e. mechanically soft materials.

*

reviews

PDMS MEMBRANE: THICKNESS OF A SPIN COATED PDMS LAYER The final PDMS layer thickness mainly depends of spin-coating speed

and duration.

*

reviews

*

reviews

MICROFLUIDIC FLOW CONTROL: SHORT REVIEW ABOUT CELLIX EXIGO SYRINGE

PUMP

Outside of conventional syringe pumps which generate flow oscillation at low flow rate we can now find syringe pump dedicated to microfluidic experiment.

*

reviews

*

reviews

*

reviews

HOW TO CHOOSE A MICROFLUIDIC TUBING ? Several parameters have to be taken into consideration while choosing a microfluidic tubing. Depending on your application, the choice of the right tubing for

*

reviews

microfluidicists.

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other areas

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reviews

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HOW TO CHOOSE THE RIGHT MICROFLUIDIC FLOW CONTROL SYSTEM? What are the strengths and weaknesses of each type of microfluidic flow control system? Pressure controller, syringe pump...?

*

reviews

*

reviews

STABILITY OF MICROFLUIDIC FLOW CONTROL INSTRUMENT The performance of your flow control instruments depends on your experimental conditions.

*

reviews

TRICKS AND TIPS TO ENHANCE YOUR MICROFLUIDIC FLOW CONTROL Despite their sturdiness & simplicity, syringe pumps are often problematic in microfluidics.

*

reviews

RESPONSIVENESS OF FLOW CONTROL INSTRUMENTS Microfluidic flow controllers are designed to control flows in

microfluidic chips.

*

reviews

RESEARCHERS’ OPINION ON FLOW CONTROL FOR MICROFLUIDICS One of the great challenges for researchers using microfluidics is miniaturizing analysis processes in very small microchip.

*

reviews

*

reviews

*

reviews

SYRINGE PUMPS AND MICROFLUIDICS In the past two years, several new microfluidic syringe pump systems have changed the use of syringe pumps in microfluidic experiments.

*

reviews

GENERATE DROPLETS IN MICROFLUIDIC CAPILLARY We focus here on how to make droplets with commercial tools, especially chromatography tools like cross or a T junctions.

*

reviews

*

reviews

WHAT IS DIGITAL MICROFLUIDICS? Digital microfluidics is an alternative technology for microfluidic systems based on the design, composition and manipulation of discrete droplets and/or bubbles.

*

reviews

*

reviews

DROPLET DETECTION AND MEASUREMENT IN MICROFLUIDIC CHANNELS The biggest advantage of droplet-based microfluidics over other droplet-based systems is the uniformity or monodispersity of the

droplets.

*

reviews

DIGITAL MICROFLUIDICS USING PRESSURE DRIVEN FLOW Making droplets in a capillary or a microfluidic device is often met

with two problems

*

reviews

PDMS QUAKE VALVES AND CO : A REVIEW PDMS pneumatic microvalves are based on the pressure-driven deformation of a soft material (generally PDMS) that clogs or releases liquid flows into microsystems.

*

reviews

MICROFLUIDIC NANOPARTICLE SYNTHESIS: A SHORT REVIEW Nanoparticles are particles with a size smaller than 100 nm. They are made up of carbon, metal, metal oxides or organic matter.

*

reviews

*

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MICROFLUIDICS AS A TOOL FOR DRUG DELIVERY Microfluidics, i.e. the science and engineering of fluid flows in microscale, can be the answer for a more effective and targeted drug

administration.

*

reviews

MICROFLUIDICS FOR DNA ANALYSIS This review presents the main applications of microfluidics for molecular analysis and its numerous techniques for DNA analysis.

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PDMS SOFTLITHOGRAPHY Here you can find a complete overview of a PDMS chip replication.

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SU-8 MOLD LITHOGRAPHY Here you can find a complete overview of a SU-8 mold fabrication

process.

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SU-8 PHOTOLITHOGRAPHY: SPIN-COATING How do you perform a successful spin coating? Here you will find the tips and tricks to do it.

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reviews

SU-8 PHOTOLITHOGRAPHY: BAKING How do you perform a successful photoresist baking? Here you will find the tips and tricks to do it.

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SU-8 PHOTOLITHOGRAPHY: UV EXPOSURE How do you perform a successful SU-8 exposure? Here you will find the tips and tricks to do it.

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SOFT LITHOGRAPHY: SU-8 BAKING Replicating PDMS-based structures first requires the fabrication of a SU-8 master mold that will serve as a patterned template for PDMS

casting

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SOFT LITHOGRAPHY SU-8 COATING In soft lithography, the fabrication of a mold, often made in SU-8, is required for replicating PDMS microfluidic structures.

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ORGANS ON CHIPS

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ORGANS ON CHIP REVIEW Multi-organs on chip could also allow us to witness the side effects of certain drugs on different organs, not limited to those that the

treatment targets.

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their drawbacks.

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HEART-ON-CHIP

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MICROFLUIDIC “MINI-BRAINS”: KEEPING UP WITH THE BRAIN-ON-CHIP

TECHNOLOGY

At the beginning of the third millennium, due to prolonged aging, neurodevelopmental disorders are growing and a much deeper understanding of the brain is necessary.

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3D CELL CULTURE: MARKET AND INDUSTRIAL NEEDS In this report, we identify the following two main purposes for the 3D

cell market

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MICROFLUIDIC FOR CELL BIOLOGY: CONCEPTS AND METHODOLOGIES We review here the basic concepts and methodologies in designing microfluidic devices, and their diverse cell biological applications.

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CORONAVIRUS (SARS-COV2) DIAGNOSTIC WITH MICROFLUIDICS Coronavirus (SARS-Cov2) diagnostic through microfluidics

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MICROFLUIDIC FABRICATION OF NANOHYDROGELS FOR DRUG-DELIVERY The authors describe the use of microfluidics for the fabrication of nanohydrogels made from hyaluronic acid derivatives, for

drug-delivery.

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ACOUSTIC TECHNIQUES FOR MICROFLUIDIC PARTICLE SORTING Acoustic techniques for sorting and separation of micron-sized particles in microfluidic devices

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MICROFLUIDIC FLOW CONTROL : SHORT REVIEW ABOUT NEW ERA NE-1002-X

SYRINGE PUMP

Outside of conventional syringe pumps which generate flow oscillation at low flow rate and long settling time, we can now find syringe pumps dedicated to microfluidic experiments.

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have developed...

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INTRODUCING THE REVIEW OF THE KD SCIENTIFIC LEGATO 180 PICOLITER

SYRINGE PUMP

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SHORT REVIEW ABOUT HARVARD APPARATUS11 PICO PLUS ELITE SYRINGE PUMP Since 1956, Harvard Apparatus offers a broad range of syringe and peristaltic pumps to suit almost every fluidic application.

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INTRODUCTION ABOUT PHOTOMASK IN MICROFLUIDICS A photolithography mask is an opaque plate or film with transparent areas that allow light to shine through a defined pattern

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SOFT-LITHOGRAPHY DEFINITIONS When you talk about microfluidics, some words can be new, we gathered here some common and relevant definitions

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MICROFLUIDIC FABRICATION TECHNICS There are different techniques to make microfluidic devices. The main ones are etching, thermoforming, polymer ablation and polymer casting

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INFLUENCE OF YOUR MICROFLUIDIC LABORATORY ENVIRONMENTAL PARAMETERS ON

YOUR PHOTOMASK

Environmental and mechanical conditions can affect the overall size of the photolithographic mask considerably when it is polyester film-made, and to a lesser degree when it is glass-made.

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MICROFLUIDIC FOUNDRIES If you don’t fabricate your microfluidic device yourself, it is important to choose the right microfluidic company to fabricate your

microfluidic chip.

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FABRICATION OF GLASS AND FILM PHOTOMASKS The photolithography mask is an important tool in soft photolithography processes, we explain here how they are made

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SOFT LITHOGRAPHY: GLASS/PDMS BONDING How do you perform a successful PDMS bonding with a plasma cleaner? Here you will find the tips and tricks to do it.

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MICROFLUIDIC 3D PRINTER Every following technology is based on the same system of additive process, every object is built layer by layer after being sliced by an

informatic system.

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SU-8 PHOTOLITHOGRAPHY : HOT PLATES A hot plate to bake your SU-8 photoresist, you will find here the relevant points to think about.

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SU-8 PHOTOLITHOGRAPHY: PHOTOMASK You have the choice between glass or plastic photolithography mask, but how do you choose? here is some information to help you with the

decision

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SU-8 PHOTOLITHOGRAPHY : SPIN COATER A spin coater creates a thin layer of photoresist or PDMS, you will find here the relevant information about how to choose one.

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PDMS SOFT LITHOGRAPHY : PLASMA CLEANER A plasma cleaner to bond your PDMS chip, you will find here the relevant points to think about.

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SU-8 PHOTOLITHOGRAPHY : UV SOURCES A UV Lamp to expose your SU-8 photoresist. You will find here the relevant points to think about.

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ORGAN-ON-CHIP: THE COMPANIES Companies researching organs-on-chip

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LABEL-FREE MICROFLUIDIC CELL SEPARATION AND SORTING TECHNIQUES: A

REVIEW

In this review we will describe some label-free microfluidic techniques to accomplish cell separation and sorting.

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CELL DEFORMATION USING MICROFLUIDIC CHIP Cells growth, gene expression and differentiation are often related to mechanical environment such as confinement or applied stresses.

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systems.

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manner.

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IMAGING AND MICROSCOPY: PERFUSION CHAMBERS The first live-cell imaging chambers were designed in the early twentieth century, shortly after mammalian cell culture techniques

were developped

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PERFUSION FOR LIVE CELL IMAGING: METHODS AND TECHNIQUES Live-cell imaging is a method which focuses on the observation of live cells and is widely used in cellular biology research and biomedical

industry.

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MICROFLUIDIC CELL CULTURE: MEDIUM CHANGE Ability to switch drugs in seconds or less in microfluidic chips allows studying cell response at cells timescale.

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PDMS IN BIOLOGY RESEARCHES: A CRITICAL REVIEW ON PDMS LITHOGRAPHY FOR

BIOLOGICAL STUDIES

PDMS advantages and drawbacks for cell biology are here discussed.

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PRESSURE-DRIVEN FLOW CONTROL In this document we will explain how pressure-driven flow control works, the advantages / disadvantages of the different technologies and how to choose between a syringe pump and pressure control depending of your requirements.

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PERFORMING LIVE CELLS ASSAYS ON CHIP This application note presents how to perform cell culture on chip using the Cell and Biology Pack and the MicroSlides developed by ALine

Inc.

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HOW TO USE ELVEFLOW MICROFLUIDIC BUBBLE DETECTOR Gas bubbles circulating through a microfluidic setup can damage the biological sample of interest and/or cause experimental errors

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DETECTION OF FLUORESCENT DROPLETS USING OPTOREADER Droplets generation has a large range of applications, such as emulsion production, single cell analysis, drug delivery or nanoparticles synthesis. Droplets can also be used as micro bioreactors for chemical or biochemical reactions.

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DROPLETS MICROFLUIDICS FOR SINGLE CELL ENCAPSULATION IN ANTIBODY THERAPY, HIGH-THROUGHPUT SCREENING AND NGS Droplet microfluidics and single cell encapsulation offer the key for a discovery engine in antibody therapy.

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MICROFLUIDIC FLOW FOCUSING DROPLET GENERATION Precise and effective control of droplet generation is critical for applications of droplet microfluidics ranging from materials synthesis to lab-on-a-chip systems.

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REAL TIME FLUORESCENT DROPLETS MONITORING The Opto Reader allows the detection and quantification of flowing particles at a given point during microfluidic experiments. The optical fiber both illuminates and captures light emitted by a fluorescent object. The optical fiber output can be focalized into a tiny spot thanks to a compact objective specifically designed for

microfluidic chips.

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APPLICATION NOTES

51 articles

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AVOID AIR BUBBLES DURING YOUR MICROFLUIDIC EXPERIMENTS Air bubbles are a very common issue for microfluidic experiments. They are very difficult to avoid, and they can be really difficult to remove from the microfluidic device. Moreover, they can be really detrimental for the experiment.

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PERISTALTIC PUMP COMPARED TO PRESSURE DRIVEN FLOW CONTROL In this review we will explain the operating principle of pressure driven flow control, the advantages / disadvantages of the different technologies and how to choose between a peristaltic pump and pressure control depending on your requirements.

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MICROFLUIDIC DROPLET IN A CHIP The droplet generation pack has been designed to fit most common droplet generation needs of researchers.

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MICROFLUIDIC DROPLETS ON DEMAND Active droplet generation in microfluidics is of high interest for a wide range of applications. It provides an additional degree of freedom in manipulating both the size and the formation frequency of micro-droplets. This additional control is extremely desirable for complex operations which rely on the accurate control of both

parameters.

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MICROFLUIDIC FLOW FOCUSING Hydrodynamic focusing is a powerful tool for microfluidicists that can be used for numerous applications, such as microfluidic mixing, separations, sensors, cell analysis, flow cytometry, diffusion-controlled chemical reactions and microfabrication. Hydrodynamic focusing occurs when fluids with different velocities are injected side by side. The most common way to perform hydrodynamic focusing is to use a 3 inlets microfluidic chips, where the core flow containing the sample of interest is sheathed by an inert fluid.

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RECIRCULATING PERFUSION MICROFLUIDIC SYSTEM The MUX Inj is a bidirectional 6-port / 2 position valve allowing to perform switches between two setup configurations. One application is to make a recirculating set-up with a flow rate always going through the chip in the same direction. In this application note, we walk you through the steps of setting up a unidirectional recirculation through a semi permeable membrane.

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DROPLETS GENERATION & MANIPULATION The generation and manipulation of droplets through microfluidics offer tremendous advantages: better control over small volumes of fluid, enhanced mixing, high throughput experiments.

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PERFORMING LIVE CELLS ASSAYS ON CHIP This application note presents how to perform cell culture on chip using the Cell and Biology Pack and the MicroSlides developed by ALine

Inc.

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HOW TO USE ELVEFLOW MICROFLUIDIC BUBBLE DETECTOR Gas bubbles circulating through a microfluidic setup can damage the biological sample of interest and/or cause experimental errors

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51 articles

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MICROFLUIDIC DROPLET IN A CHIP The droplet generation pack has been designed to fit most common droplet generation needs of researchers.

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CONTROLLED MEDIUM SWITCH ON A MICROFLUIDIC CHIP Changing the injected liquid inside a microfluidic device has numerous applications, such as sequential sample injection for biochemistry and flow chemistry, or medium switch for cell biology and 3D cell culture on chip. The easiest solution is to replace the liquid injected, but it is often not possible:

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PRESSURE SENSOR FEEDBACK LOOP Monitor real time pressure wherever in your setup The aim of this application note is to show how to install the pressure feedback anywhere in your setup.

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FLUORESCENCE PROBE QUANTIFICATION The fluorescence probe is a robust and highly sensitive approach for detecting trace amounts of substance owing to its simplicity and non-invasiveness. Moreover, the use of optical methods, which is usually low cost, light-weight, high throughput and can be easily deployed in large scale for on-field or point-of-care applications.

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MICROFLUIDIC DROPLET IN A CHIP The droplet generation pack has been designed to fit most common droplet generation needs of researchers.

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PERFORMING LIVE CELLS ASSAYS ON CHIP This application note presents how to perform cell culture on chip using the Cell and Biology Pack and the MicroSlides developed by ALine

Inc.

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HOW TO USE ELVEFLOW MICROFLUIDIC BUBBLE DETECTOR Gas bubbles circulating through a microfluidic setup can damage the biological sample of interest and/or cause experimental errors

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microfluidic chips.

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DIGITAL MICROFLUIDICS: DROPLET GENERATION INSIDE A MICROFLUIDIC CHIP Droplets generation has a large scale of applications, such as emulsion production, single cell analysis, drug delivery or nanoparticles synthesis. Droplets can also be used as micro bioreactors for chemical or biochemical reactions.

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DROPLET GENERATION INSIDE A CAPILLARY This application note describes how to generate controlled size millifluidic droplets in a capillary by regulating the pressure rate and/or by regulating the flow rate.

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DETECTION OF MICRO PARTICLES The detection of micro particles in a flow is a routine task in many domains, e.g. cell biology, chromatography, medical and environmental research, etc. This task is commonly performed on conventional epi-fluorescence microscopy which is highly precise but is space consuming, requires an important investment and is confusing for

non-experts.

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FIBER OPTIC SENSOR

The OptoReader is a highly sensitive detection device taking advantage of advanced photo-detection technologies. Its optical fiber based design and its capacity of both excitation and detection of fluorescence makes it the ideal device for working with fiber optic

sensors.

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TISSUE-ENGINEERING: HEART VENTRICULE ASSISTED BY A MICROFLUIDIC

PRESSURE PUMP

Until recently, microfluidic devices have been employed to support tissue-engineering experiments on basal lamina, vascular tissue, liver, bone, cartilage and neurons as well as organ-on-chips.

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CIRCULATING TUMOR CELLS ENTRAPMENT USING MICROFLUIDICS Prostate cancer is the second leading cause of cancer-related death for men. Circulating tumor cells (CTCs) are considered as a marker of early cancer diagnosis and disease severity. Their screening in blood is thus crucial to detect metastatic stage in cancer patients.

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FLUORESCENCE READER FOR MICROFLUIDIC QPCR Fluorescence reader for microfluidic qPCR: faster, more sensitive and less expensive than most optical microscopes, it is a smart alternative for real-time fluorescence measurements of your on-chip

qPCR signal.

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MICROFLUIDIC PERFUSION MEDIUM SWITCH USING IBIDI© CHIPS Medium switch is widely used in cell biology. One application is the study of cell behavior under given flow conditions for different samples. In this tutorial, we walk you through the steps of a fast and stable medium switch using IBIDI© flow cells.

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USING THE PERFUSION PACK TO PERFORM FAST MEDIUM SWITCH In this application note, we will describe how to perform an automated and fast medium switch thanks to the Perfusion Pack.

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MICROFLUIDIC CARDIAC CELL CULTURE MODEL This application note proposes a microfluidic cardiac cell culture model (μCCCM) to recreate mechanical loading conditions observed in the native heart (in both normal and pathological conditions) by using an Elveflow OB1 pressure and flow controller.

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FLOW REGULATION WITH FLOW SENSORS AND SMART INTERFACE The aim of this application note is to show how to easily perform a very responsive and precise flow rate control anywhere in your setup by using an Elveflow® OB1 pressure & flow controller and a Bronkhorst® flow sensor.

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FLUID HANDLING

Microfluidics is the science of handling small amounts of liquids, inside micrometer scale channels. Discover how to handle fluids for your microfluidic experiments.

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DROPLETS ON DEMAND IN MICROFLUIDIC NETWORKS Two-phase flow microfluidics allow to perfom different laboratory functions on one microfluidic Lab-on-Chip (LoC) platform. An example of such an application is the controlled production of droplets on

chip.

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FLOW CHEMISTRY AND SAMPLE PREPARATION The advent of microfluidics as a tool for chemical synthesis is coming of age, particularly in industrial techniques. It has many advantages over conventional techniques such as as small reagent consumption, improved selectivity, less stringent reaction clean up, rapid reactions and small footprints.

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CELL BIOLOGY

Microfluidics is widely used to develop tools for cell biology. The micrometer scale of microfluidic devices is particularly adapted to

work with cells.

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WEAK PROTEIN INTERACTIONS QUANTIFIED USING A MICROFLUIDIC PUMP This article covers the development of an experimental method enabling Shahar Sukenik et al. to study protein interactions and detect the dissociation of GAPDH and PGK proteins in order to quantify their stoichiometry directly inside the cell by modulating the cell-volume

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FOAM-OIL INTERACTIONS IN A 3D POROUS MEDIUM USING MICROFLUIDICS Accidental spillage of petroleum-based products and contaminants can cause severe environmental hazards to the ecosystem if not remediated effectively. Foam, a dispersion of gas in thin liquid films (named lamellae), has been identified as a remedy for these defects due to its unique properties.

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STIMULATION OF C. ELEGANS MECHANORECEPTOR NEURONS USING MICROFLUIDICS This article covers the work of Adam L. Nekimken et al. published in Lab Chip in January 2017. The research team introduced a novel microfluidic device that enables high-resolution imaging of cellular deformations in response to precise mechanical stimuli to the surface of the C. Elegans worm cuticle.

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HOW TO CHOOSE FLOW REGULATION PARAMETERS? Flow regulation is a compulsory operation in most of the microfluidics operations. In some applications such as 2D or 3D cell culture, flow regulation is essential since accurate micro-environmental parameters control is required. Elveflow do it’s best to make this operation as easy as possible to help you to focus on what really matter in your

setup.

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CONTROLLED MICROFLUIDIC SAMPLE INJECTION The MUX inj is a bidirectional 6-port / 2 position valve allowing to perform switches between two set-up configurations. One application is to perform a stable and unidirectional fluid recirculation or to inject a precisely controlled volume of drug. This application note focuses on the example and will walk you through the steps of a successful experiment.

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FLOW MEASUREMENT WITH FLOW SENSORS AND SMART INTERFACE How to control the flow rate in your setup with very high accuracy? The aim of this application note is to show how to easily perform a very responsive and precise flow rate control anywhere in your setup by using an Elveflow® OB1 pressure & flow controller and a Bronkhorst® flow sensor.

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REDIRECTING FLOW WITH A MICROFLUIDIC VALVE CONTROLLER The MUX Wire enables you to host up & control many valves of your choice. It gives you a total freedom to add up to 16 valves and put them anywhere in your set-up and control them independently and

simultaneously.

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RHEODYNE MICROFLUIDIC VALVE BIDIRECTIONAL TEN-WAY INJECTION Maintain a controlled flow rate? This application note aims to help you maintain a controlled flow rate during a flow line switch thanks to the Mux Distributor. This valve allows to switch between up to 10 lines to inject several fluids sequentially in your system. It has many applications such as sequential sample injection for biochemistry and flow chemistry, or medium switch for cell biology on chip.

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MICROFLUIDIC FLOW RESTRICTORS The flow rate in every fluidic system can be computed with the following equation: ∆P=Q×Rh Where: ∆P is the pressure difference between the inlet and the outlet of the system, Q is the flow rate throughout the system, Rh is the fluidic resistance of the system.

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MICROFLUIDIC THE ZERO FLOW This application note describes how to generate a controlled flow inside a microfluidic chip and stop it completely (zero flow) by using an Elveflow® MUX and an Elveflow® pressure control instrument (OB1).

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MICROFLUIDIC SOFT-ROBOTS SOFT-ROBOTICS: CREATION AND CONTROL OF MICROFLUIDIC SOFT-ROBOTS

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USING AN ELVEFLOW CONTROLLER AS A SYRINGE PUMP This application note describes how to set and monitor a determined liquid flow rate and perform a flow control for your microfluidic experiments by using an Elveflow® pressure & flow control instrument and a flow sensor. The new version of the Elveflow® smart software allows to virtually turn your pressure controller into a syringe pump keeping the advantages of both methods (high performance, ease of use, intuitiveness, etc.)

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PRESSURE DRIVEN FLOW CONTROL FOR NANOFLUIDICS Nanofluidics is the study of the behaviour, manipulation, and control of fluids that are confined to structures of nanometer characteristic dimensions. Various reasons may be found to motivate the development of Nanofluidics. From a biotechnological point of view, decreasing the scales considerably increases the sensitivity of analytic techniques. From a fluidic point of view, nanometric scales allow new fluidic functionalities to be developed, using the explicit benefit of the predominance of surfaces.

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HOW TO CONTROL THE FLOW USING AN OB1 PRESSURE CONTROLLER AND A FLOW

SENSOR?

Microfluidic flow control : The OB1® pressure controller has the advantage to be the faster and the most stable of the microfluidic flow controller. In combination with a flow sensor, it can also perform an ultra-precise flow control and monitor the amount of liquid injected in a chips. You can request a flow rate value in the Elveflow Software and the pressure controller will automatically adjust pressure to reach the requested value thanks to a customizable PID Feedback loop. This application note aims to guide you to easily perform this flow control.

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OB1 PRESSURE CONTROLLER: HOW TO INSTALL OUT OF THE BOX A series of videos produced specifically to provide our customers with the best experience.

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MICROFLUIDIC CONTROLLED DRUG SWITCH This application note shows how to easily perform controlled drug switches on an hypothetic chemical or biological environment (drug screening or cell culture) with an Elveflow® MUX as shown on these

pictures:

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MICROFLUIDIC FAST MEDIUM SWITCH (OB1) This application note shows how to perform an ultrafast microfluidic medium (drugs, samples, etc) change in an hypothetical chemical or biological environment, performed with an Elveflow® pressure & flow control instrument (OB1) as shown in these pictures:

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MICROFLUIDIC FAST MEDIUM SWITCH (OB1+MUX) This application note shows how to perform an ultrafast microfluidic medium switch (drugs, samples, etc) in an hypothetical chemical or biological environment, performed with an Elveflow® OB1 and an

Elveflow® MUX

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FAST MEDIUM SWITCH OB1 VS. OB1+MUX Fast medium switch in microfluidic channels is generally a required technique to perform a wide range of biomedical and chemical microfluidic assays, such as the analysis of living cells in vitro, particle washing, etc.

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PRESSURE SENSOR FEEDBACK LOOP Monitor real time pressure wherever in your setup The aim of this application note is to show how to install the pressure feedback anywhere in your setup.

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MICROFLUIDIC DROPLET IN A CHIP The droplet generation pack has been designed to fit most common droplet generation needs of researchers.

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MICROFLUIDIC DROPLET IN A CHIP The droplet generation pack has been designed to fit most common droplet generation needs of researchers.

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PERFORMING LIVE CELLS ASSAYS ON CHIP This application note presents how to perform cell culture on chip using the Cell and Biology Pack and the MicroSlides developed by ALine

Inc.

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HOW TO USE ELVEFLOW MICROFLUIDIC BUBBLE DETECTOR Gas bubbles circulating through a microfluidic setup can damage the biological sample of interest and/or cause experimental errors

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FIBER OPTIC SENSOR

sensors.

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TISSUE-ENGINEERING: HEART VENTRICULE ASSISTED BY A MICROFLUIDIC

PRESSURE PUMP

Until recently, microfluidic devices have been employed to support tissue-engineering experiments on basal lamina, vascular tissue, liver, bone, cartilage and neurons as well as organ-on-chips.

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qPCR signal.

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USING THE PERFUSION PACK TO PERFORM FAST MEDIUM SWITCH In this application note, we will describe how to perform an automated and fast medium switch thanks to the Perfusion Pack.

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FLUID HANDLING

Microfluidics is the science of handling small amounts of liquids, inside micrometer scale channels. Discover how to handle fluids for your microfluidic experiments.

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CELL BIOLOGY

Microfluidics is widely used to develop tools for cell biology. The micrometer scale of microfluidic devices is particularly adapted to

work with cells.

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MICROFLUIDIC SOFT-ROBOTS SOFT-ROBOTICS: CREATION AND CONTROL OF MICROFLUIDIC SOFT-ROBOTS

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HOW TO CONTROL THE FLOW USING AN OB1 PRESSURE CONTROLLER AND A FLOW

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OB1 PRESSURE CONTROLLER: HOW TO INSTALL OUT OF THE BOX A series of videos produced specifically to provide our customers with the best experience.

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Elveflow® MUX

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TECHNOLOGY

PIEZOELECTRIC ACTUATORS Elveflow’s Flow Controllers use unique patented piezoelectric actuators which provide unparalleled performance in terms of robustness, speed, responsiveness, accuracy and stability, even with large reservoir volumes. CORIOLIS FLOW METERS Elveflow is the unique supplier of Coriolis Flow Meters, brought to the scientific community in collaboration with our partner Bronkhorst. This unique flow meter requires no calibration, is compatible with any liquid, and has an extensive operating flow rate range with unmatched accuracy (down to 0.2%). NATIONAL INSTRUMENTS National Instruments is our technological partner for embedded electronics and software. This proven and reliable technology delivers robustness, ease-of-use and accelerated development of new

capabilities.

OEM & CUSTOM DEVELOPMENT Does your industry need a microfluidic element, whether in your production line, or for your next product generation? Thanks to our OEM product line and custom offers, we will help you fill the gap between your need, and the most advanced proof-of-concept microfluidic development from academics. When it comes to microfluidic flow control, if someone in the world can do it, we can do it for you.

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We ship our products to your location, no matter where you are in the world. Nobody gets left behind! DISTRIBUTORS ALL AROUND THE WORLD We can either directly take care of your request or put you in contact with one of our distributors in your geographical area. RESEARCHERS ARE OUR BEST AMBASSADORS, AND VICE VERSA If we both want to push back scientific limits using microfluidics, if you love the instruments we develop and if we enjoy working together, why not join our ambassador team? We can promote your research through short reviews and scientific highlights, give you discounts, start collaborative projects, share tips and tricks, and much more!

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At Elveflow, we’re passionate about SCIENTIFIC PROGRESS. We’ve observed that new scientific instruments are the game-changers that lead to the greatest scientific discoveries, and that’s why we set up our microfluidic instrumentation company. Not for profit – that’s a mean, not an end. JUST BECAUSE WE WANT TO HELP YOU MAKE

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We will only sell you instrumentation that you need, and we commit to making the best tools you can ask for. Ask us, actually: what does your application need? We want you to succeed, whether you’re a confirmed microfluidicist or just starting out. We believe in this technology. Together, let's create these moments of shared happiness and scientific victory.

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SOFTWARE - ELVEFLOW

of

of dynamic flow

stored.

success.

SOFTWARE - ELVEFLOW

of

of dynamic flow

stored.

success.

of dynamic flow

January, 2021.

stress

INJECTION VALVE

our experts.

HEART-ON-CHIP

SOFTWARE - ELVEFLOW

of

of dynamic flow

stored.

success.

SOFTWARE - ELVEFLOW

of

of dynamic flow

stored.

success.

of dynamic flow

January, 2021.

stress