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INSTITUT DE DUVE
Institut de Duve. Make a gift. The de Duve Institute is a multidisciplinary biomedical research institute hosting several laboratories of the faculty of medicine of UCL (Université catholique de Louvain), as well as the Brussels branch of the Ludwig Institute. JEAN-FRANÇOIS COLLET Jean-François Collet | Institut de Duve. For beginners. For experts. Publications. Highlights. The emergence of bacteria resistant to all of the available antibacterial agents calls for the urgent development of new molecules to fight bacterial infections. The goal of our laboratory is to understand how bacterial cells respond to toxic PATRICK JACQUEMIN & FRÉDÉRIC LEMAIGRE Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells. Augereau C, Collet L, Vargiu P, Guerra C, Ortega S, Lemaigre FP, Jacquemin P. Hum Mol Genet. 2016; 25 (22):5017-26. Transcription factors SOX4 andMIIKKA VIKKULA
Lymphedema. Lymphedema is a strongly invalidating chronic disease resulting from abnormal development and/or function of the lymphatic system. Lymph is not drained from interstitial tissues, but accumulates, most often in lower extremities, causing enlargement, fibrosis and predisposition to secondary infections. ANABELLE DECOTTIGNIES Anabelle Decottignies. For beginners. For experts. Publications. Highlights. In our laboratory, we are interested in understanding the mechanisms that are set up by cancer cells to acquire this “endless youthful” property that ensures indefinite cellular proliferation potential. Understanding these mechanisms is expected to helpidentifying
LAURENT GATTO
Bioinformatics. 2019; 35 (17):3151-3153. Assessing sub-cellular resolution in spatial proteomics experiments. Gatto L, Breckels LM, Lilley KS. Curr Opin Chem Biol. 2018; 48:123-49. A Bayesian mixture modelling approach for spatial proteomics. Crook OM, Mulvey CM, Kirk PDW, Lilley KS, Gatto L. PIERRE VAN DER BRUGGEN The de Duve Institute has played a key role in demonstrating this concept because the first tumor antigens have been discovered here by the team of Thierry Boon. Pierre van der Bruggen and Catia Traversari were at the forefront. Dozens of these antigens recognized by cytolytic T lymphocytes are now known, and many remain to bediscovered.
DONATIENNE TYTECA
Donatienne Tyteca. For beginners. For experts. Publications. Highlights. Some cells, such as red blood cells and muscular cells, must resist strong deformation. Disorders of these deformations are the basis of membrane fragility diseases such as spherocytosis (a disease of red blood cells) or Duchenne myopathy (which affectsmuscular cells).
NISHA LIMAYE
Nat Med. 2008; 14 (11):1236-46. Prevalence and evolutionary origins of autoimmune susceptibility alleles in natural mouse populations. Limaye N, Belobrajdic KA, Wandstrat AE, Bonhomme F, Edwards SV, Wakeland EK. Genes Immun. 2008; 9 (1):61-8. PAM1 MUTATION MATRIX Mutation probability matrix for the evolutionary distance of 1 PAM (i.e., one Accepted Point Mutation per 100 amino acids).INSTITUT DE DUVE
Institut de Duve. Make a gift. The de Duve Institute is a multidisciplinary biomedical research institute hosting several laboratories of the faculty of medicine of UCL (Université catholique de Louvain), as well as the Brussels branch of the Ludwig Institute. JEAN-FRANÇOIS COLLET Jean-François Collet | Institut de Duve. For beginners. For experts. Publications. Highlights. The emergence of bacteria resistant to all of the available antibacterial agents calls for the urgent development of new molecules to fight bacterial infections. The goal of our laboratory is to understand how bacterial cells respond to toxic PATRICK JACQUEMIN & FRÉDÉRIC LEMAIGRE Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells. Augereau C, Collet L, Vargiu P, Guerra C, Ortega S, Lemaigre FP, Jacquemin P. Hum Mol Genet. 2016; 25 (22):5017-26. Transcription factors SOX4 andMIIKKA VIKKULA
Lymphedema. Lymphedema is a strongly invalidating chronic disease resulting from abnormal development and/or function of the lymphatic system. Lymph is not drained from interstitial tissues, but accumulates, most often in lower extremities, causing enlargement, fibrosis and predisposition to secondary infections. ANABELLE DECOTTIGNIES Anabelle Decottignies. For beginners. For experts. Publications. Highlights. In our laboratory, we are interested in understanding the mechanisms that are set up by cancer cells to acquire this “endless youthful” property that ensures indefinite cellular proliferation potential. Understanding these mechanisms is expected to helpidentifying
LAURENT GATTO
Bioinformatics. 2019; 35 (17):3151-3153. Assessing sub-cellular resolution in spatial proteomics experiments. Gatto L, Breckels LM, Lilley KS. Curr Opin Chem Biol. 2018; 48:123-49. A Bayesian mixture modelling approach for spatial proteomics. Crook OM, Mulvey CM, Kirk PDW, Lilley KS, Gatto L. PIERRE VAN DER BRUGGEN The de Duve Institute has played a key role in demonstrating this concept because the first tumor antigens have been discovered here by the team of Thierry Boon. Pierre van der Bruggen and Catia Traversari were at the forefront. Dozens of these antigens recognized by cytolytic T lymphocytes are now known, and many remain to bediscovered.
DONATIENNE TYTECA
Donatienne Tyteca. For beginners. For experts. Publications. Highlights. Some cells, such as red blood cells and muscular cells, must resist strong deformation. Disorders of these deformations are the basis of membrane fragility diseases such as spherocytosis (a disease of red blood cells) or Duchenne myopathy (which affectsmuscular cells).
NISHA LIMAYE
Nat Med. 2008; 14 (11):1236-46. Prevalence and evolutionary origins of autoimmune susceptibility alleles in natural mouse populations. Limaye N, Belobrajdic KA, Wandstrat AE, Bonhomme F, Edwards SV, Wakeland EK. Genes Immun. 2008; 9 (1):61-8. PAM1 MUTATION MATRIX Mutation probability matrix for the evolutionary distance of 1 PAM (i.e., one Accepted Point Mutation per 100 amino acids). RESEARCH | INSTITUT DE DUVE Inflammation is a response to a variety of aggressions, including infections. It normally leads to healing, but when excessive or ill-controlled, it can induce so-called inflammatory diseases. We study key mechanisms involved in inflammatory diseases affecting the gut (Crohn's disease) , lung (asthma) or skin (psoriasis). Viruses. JEAN-FRANÇOIS COLLET Jean-François Collet | Institut de Duve. For beginners. For experts. Publications. Highlights. The emergence of bacteria resistant to all of the available antibacterial agents calls for the urgent development of new molecules to fight bacterial infections. The goal of our laboratory is to understand how bacterial cells respond to toxic ANABELLE DECOTTIGNIES Anabelle Decottignies. For beginners. For experts. Publications. Highlights. In our laboratory, we are interested in understanding the mechanisms that are set up by cancer cells to acquire this “endless youthful” property that ensures indefinite cellular proliferation potential. Understanding these mechanisms is expected to helpidentifying
CELLULAR METABOLISM & MICROENVIRONMENT We use state-of-the-art metabolic analysis techniques in combination with cell and animal models to investigate how metabolites produced by one cell type influence the behavior of the other cells in its environment. The goal of our research is to identify niche-derived metabolic signals important for the maintenance of blood stem cellsand the
VASCULAR ANOMALIES
Vascular Anomalies. Involved group members: Miikka Vikkula, Nisha Limaye, Pascal Brouillard, Mustapha Amyere, Ha-Long Nguyen, Laurence Boon, Nicole Revencu Vascular anomalies are localized defects of the blood or lymphatic vasculature that arise during embryonic development and are typically observed at birth or soon after.PIERRE COULIE
T-cells can also recognize tumour cells. About thirty years ago, T. Boon and colleagues at the de Duve Institute and Brussels branch of the Ludwig Institute discovered specific markers on the surface of cancer cells (called tumor antigens) that can be recognized by T-cells, which then destroy the tumor cells.NISHA LIMAYE
Nat Med. 2008; 14 (11):1236-46. Prevalence and evolutionary origins of autoimmune susceptibility alleles in natural mouse populations. Limaye N, Belobrajdic KA, Wandstrat AE, Bonhomme F, Edwards SV, Wakeland EK. Genes Immun. 2008; 9 (1):61-8. PHD STUDENT DAY, MEI 26, 2021 11:05 Can lipoproteins decorate Escherichia coli’s surface? (Naemi Csoma) 11:25 EVs: actors and markers of thyroid cancers (Ophélie Delcorte). 11:45 Role of hypoxia and HIF-1α in the immunosuppressive tumor microenvironment (Tereza Dvorakova). 12:05 Cardiovirus L proteins-mediated FG-nucleoporins phosphorylation (Belén Lizcano Perret). 12:25 – 12:40 Quizz (winner: Laura Glorieux) PEOPLE | INSTITUT DE DUVE Contact Us Feel Free to Get in Touch Contribute See How You Can Help NEIGHBOR-JOINING METHOD The Neighbor-Joining Method. Neighbor-joining (Saitou and Nei, 1987) is a method that is related to the cluster method but does not require the data to be ultrametric.INSTITUT DE DUVE
Institut de Duve. Make a gift. The de Duve Institute is a multidisciplinary biomedical research institute hosting several laboratories of the faculty of medicine of UCL (Université catholique de Louvain), as well as the Brussels branch of the Ludwig Institute. JEAN-FRANÇOIS COLLET Jean-François Collet | Institut de Duve. For beginners. For experts. Publications. Highlights. The emergence of bacteria resistant to all of the available antibacterial agents calls for the urgent development of new molecules to fight bacterial infections. The goal of our laboratory is to understand how bacterial cells respond to toxic PATRICK JACQUEMIN & FRÉDÉRIC LEMAIGRE Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells. Augereau C, Collet L, Vargiu P, Guerra C, Ortega S, Lemaigre FP, Jacquemin P. Hum Mol Genet. 2016; 25 (22):5017-26. Transcription factors SOX4 andMIIKKA VIKKULA
Lymphedema. Lymphedema is a strongly invalidating chronic disease resulting from abnormal development and/or function of the lymphatic system. Lymph is not drained from interstitial tissues, but accumulates, most often in lower extremities, causing enlargement, fibrosis and predisposition to secondary infections. ANABELLE DECOTTIGNIES Anabelle Decottignies. For beginners. For experts. Publications. Highlights. In our laboratory, we are interested in understanding the mechanisms that are set up by cancer cells to acquire this “endless youthful” property that ensures indefinite cellular proliferation potential. Understanding these mechanisms is expected to helpidentifying
LAURENT GATTO
Bioinformatics. 2019; 35 (17):3151-3153. Assessing sub-cellular resolution in spatial proteomics experiments. Gatto L, Breckels LM, Lilley KS. Curr Opin Chem Biol. 2018; 48:123-49. A Bayesian mixture modelling approach for spatial proteomics. Crook OM, Mulvey CM, Kirk PDW, Lilley KS, Gatto L. PIERRE VAN DER BRUGGEN The de Duve Institute has played a key role in demonstrating this concept because the first tumor antigens have been discovered here by the team of Thierry Boon. Pierre van der Bruggen and Catia Traversari were at the forefront. Dozens of these antigens recognized by cytolytic T lymphocytes are now known, and many remain to bediscovered.
DONATIENNE TYTECA
Donatienne Tyteca. For beginners. For experts. Publications. Highlights. Some cells, such as red blood cells and muscular cells, must resist strong deformation. Disorders of these deformations are the basis of membrane fragility diseases such as spherocytosis (a disease of red blood cells) or Duchenne myopathy (which affectsmuscular cells).
NISHA LIMAYE
Nat Med. 2008; 14 (11):1236-46. Prevalence and evolutionary origins of autoimmune susceptibility alleles in natural mouse populations. Limaye N, Belobrajdic KA, Wandstrat AE, Bonhomme F, Edwards SV, Wakeland EK. Genes Immun. 2008; 9 (1):61-8. PAM1 MUTATION MATRIX Mutation probability matrix for the evolutionary distance of 1 PAM (i.e., one Accepted Point Mutation per 100 amino acids).INSTITUT DE DUVE
Institut de Duve. Make a gift. The de Duve Institute is a multidisciplinary biomedical research institute hosting several laboratories of the faculty of medicine of UCL (Université catholique de Louvain), as well as the Brussels branch of the Ludwig Institute. JEAN-FRANÇOIS COLLET Jean-François Collet | Institut de Duve. For beginners. For experts. Publications. Highlights. The emergence of bacteria resistant to all of the available antibacterial agents calls for the urgent development of new molecules to fight bacterial infections. The goal of our laboratory is to understand how bacterial cells respond to toxic PATRICK JACQUEMIN & FRÉDÉRIC LEMAIGRE Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells. Augereau C, Collet L, Vargiu P, Guerra C, Ortega S, Lemaigre FP, Jacquemin P. Hum Mol Genet. 2016; 25 (22):5017-26. Transcription factors SOX4 andMIIKKA VIKKULA
Lymphedema. Lymphedema is a strongly invalidating chronic disease resulting from abnormal development and/or function of the lymphatic system. Lymph is not drained from interstitial tissues, but accumulates, most often in lower extremities, causing enlargement, fibrosis and predisposition to secondary infections. ANABELLE DECOTTIGNIES Anabelle Decottignies. For beginners. For experts. Publications. Highlights. In our laboratory, we are interested in understanding the mechanisms that are set up by cancer cells to acquire this “endless youthful” property that ensures indefinite cellular proliferation potential. Understanding these mechanisms is expected to helpidentifying
LAURENT GATTO
Bioinformatics. 2019; 35 (17):3151-3153. Assessing sub-cellular resolution in spatial proteomics experiments. Gatto L, Breckels LM, Lilley KS. Curr Opin Chem Biol. 2018; 48:123-49. A Bayesian mixture modelling approach for spatial proteomics. Crook OM, Mulvey CM, Kirk PDW, Lilley KS, Gatto L. PIERRE VAN DER BRUGGEN The de Duve Institute has played a key role in demonstrating this concept because the first tumor antigens have been discovered here by the team of Thierry Boon. Pierre van der Bruggen and Catia Traversari were at the forefront. Dozens of these antigens recognized by cytolytic T lymphocytes are now known, and many remain to bediscovered.
DONATIENNE TYTECA
Donatienne Tyteca. For beginners. For experts. Publications. Highlights. Some cells, such as red blood cells and muscular cells, must resist strong deformation. Disorders of these deformations are the basis of membrane fragility diseases such as spherocytosis (a disease of red blood cells) or Duchenne myopathy (which affectsmuscular cells).
NISHA LIMAYE
Nat Med. 2008; 14 (11):1236-46. Prevalence and evolutionary origins of autoimmune susceptibility alleles in natural mouse populations. Limaye N, Belobrajdic KA, Wandstrat AE, Bonhomme F, Edwards SV, Wakeland EK. Genes Immun. 2008; 9 (1):61-8. PAM1 MUTATION MATRIX Mutation probability matrix for the evolutionary distance of 1 PAM (i.e., one Accepted Point Mutation per 100 amino acids). RESEARCH | INSTITUT DE DUVE Inflammation is a response to a variety of aggressions, including infections. It normally leads to healing, but when excessive or ill-controlled, it can induce so-called inflammatory diseases. We study key mechanisms involved in inflammatory diseases affecting the gut (Crohn's disease) , lung (asthma) or skin (psoriasis). Viruses. JEAN-FRANÇOIS COLLET Jean-François Collet | Institut de Duve. For beginners. For experts. Publications. Highlights. The emergence of bacteria resistant to all of the available antibacterial agents calls for the urgent development of new molecules to fight bacterial infections. The goal of our laboratory is to understand how bacterial cells respond to toxic ANABELLE DECOTTIGNIES Anabelle Decottignies. For beginners. For experts. Publications. Highlights. In our laboratory, we are interested in understanding the mechanisms that are set up by cancer cells to acquire this “endless youthful” property that ensures indefinite cellular proliferation potential. Understanding these mechanisms is expected to helpidentifying
CELLULAR METABOLISM & MICROENVIRONMENT We use state-of-the-art metabolic analysis techniques in combination with cell and animal models to investigate how metabolites produced by one cell type influence the behavior of the other cells in its environment. The goal of our research is to identify niche-derived metabolic signals important for the maintenance of blood stem cellsand the
VASCULAR ANOMALIES
Vascular Anomalies. Involved group members: Miikka Vikkula, Nisha Limaye, Pascal Brouillard, Mustapha Amyere, Ha-Long Nguyen, Laurence Boon, Nicole Revencu Vascular anomalies are localized defects of the blood or lymphatic vasculature that arise during embryonic development and are typically observed at birth or soon after.PIERRE COULIE
T-cells can also recognize tumour cells. About thirty years ago, T. Boon and colleagues at the de Duve Institute and Brussels branch of the Ludwig Institute discovered specific markers on the surface of cancer cells (called tumor antigens) that can be recognized by T-cells, which then destroy the tumor cells.NISHA LIMAYE
Nat Med. 2008; 14 (11):1236-46. Prevalence and evolutionary origins of autoimmune susceptibility alleles in natural mouse populations. Limaye N, Belobrajdic KA, Wandstrat AE, Bonhomme F, Edwards SV, Wakeland EK. Genes Immun. 2008; 9 (1):61-8. PHD STUDENT DAY, MEI 26, 2021 11:05 Can lipoproteins decorate Escherichia coli’s surface? (Naemi Csoma) 11:25 EVs: actors and markers of thyroid cancers (Ophélie Delcorte). 11:45 Role of hypoxia and HIF-1α in the immunosuppressive tumor microenvironment (Tereza Dvorakova). 12:05 Cardiovirus L proteins-mediated FG-nucleoporins phosphorylation (Belén Lizcano Perret). 12:25 – 12:40 Quizz (winner: Laura Glorieux) PEOPLE | INSTITUT DE DUVE Contact Us Feel Free to Get in Touch Contribute See How You Can Help NEIGHBOR-JOINING METHOD The Neighbor-Joining Method. Neighbor-joining (Saitou and Nei, 1987) is a method that is related to the cluster method but does not require the data to be ultrametric.INSTITUT DE DUVE
Institut de Duve. Make a gift. The de Duve Institute is a multidisciplinary biomedical research institute hosting several laboratories of the faculty of medicine of UCL (Université catholique de Louvain), as well as the Brussels branch of the Ludwig Institute. JEAN-FRANÇOIS COLLET Jean-François Collet | Institut de Duve. For beginners. For experts. Publications. Highlights. The emergence of bacteria resistant to all of the available antibacterial agents calls for the urgent development of new molecules to fight bacterial infections. The goal of our laboratory is to understand how bacterial cells respond to toxic PATRICK JACQUEMIN & FRÉDÉRIC LEMAIGRE Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells. Augereau C, Collet L, Vargiu P, Guerra C, Ortega S, Lemaigre FP, Jacquemin P. Hum Mol Genet. 2016; 25 (22):5017-26. Transcription factors SOX4 and LAURE DUMOUTIER & JEAN-CHRISTOPHE RENAULD Laure Dumoutier & Jean-Christophe Renauld | Institut de Duve. For beginners. For experts. Publications. Highlights. Diseases such as asthma, psoriasis (disease affecting the skin), inflammatory bowel disease or cancer are associated with a dysregulation of the inflammatory response. In our laboratory, we try to improve the understanding of the PIERRE VAN DER BRUGGEN The de Duve Institute has played a key role in demonstrating this concept because the first tumor antigens have been discovered here by the team of Thierry Boon. Pierre van der Bruggen and Catia Traversari were at the forefront. Dozens of these antigens recognized by cytolytic T lymphocytes are now known, and many remain to bediscovered.
DONATIENNE TYTECA
Donatienne Tyteca. For beginners. For experts. Publications. Highlights. Some cells, such as red blood cells and muscular cells, must resist strong deformation. Disorders of these deformations are the basis of membrane fragility diseases such as spherocytosis (a disease of red blood cells) or Duchenne myopathy (which affectsmuscular cells).
NEIGHBOR-JOINING METHOD The Neighbor-Joining Method. Neighbor-joining (Saitou and Nei, 1987) is a method that is related to the cluster method but does not require the data to be ultrametric. PAM1 MUTATION MATRIX Mutation probability matrix for the evolutionary distance of 1 PAM (i.e., one Accepted Point Mutation per 100 amino acids). ORTHOLOGOUS AND PARALOGOUS GENES What are orthologous and what are paralogous genes ? It is said that: Two genes are to be orthologous if they diverged after a speciationevent,
HARMFUL EFFECTS OF THE PARASITE ON THE HOST Many parasites cause harmful effects to their host, but in most cases these effects are not of such importance that the host is being killed. Such effects comprise:INSTITUT DE DUVE
Institut de Duve. Make a gift. The de Duve Institute is a multidisciplinary biomedical research institute hosting several laboratories of the faculty of medicine of UCL (Université catholique de Louvain), as well as the Brussels branch of the Ludwig Institute. JEAN-FRANÇOIS COLLET Jean-François Collet | Institut de Duve. For beginners. For experts. Publications. Highlights. The emergence of bacteria resistant to all of the available antibacterial agents calls for the urgent development of new molecules to fight bacterial infections. The goal of our laboratory is to understand how bacterial cells respond to toxic PATRICK JACQUEMIN & FRÉDÉRIC LEMAIGRE Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells. Augereau C, Collet L, Vargiu P, Guerra C, Ortega S, Lemaigre FP, Jacquemin P. Hum Mol Genet. 2016; 25 (22):5017-26. Transcription factors SOX4 and LAURE DUMOUTIER & JEAN-CHRISTOPHE RENAULD Laure Dumoutier & Jean-Christophe Renauld | Institut de Duve. For beginners. For experts. Publications. Highlights. Diseases such as asthma, psoriasis (disease affecting the skin), inflammatory bowel disease or cancer are associated with a dysregulation of the inflammatory response. In our laboratory, we try to improve the understanding of the PIERRE VAN DER BRUGGEN The de Duve Institute has played a key role in demonstrating this concept because the first tumor antigens have been discovered here by the team of Thierry Boon. Pierre van der Bruggen and Catia Traversari were at the forefront. Dozens of these antigens recognized by cytolytic T lymphocytes are now known, and many remain to bediscovered.
DONATIENNE TYTECA
Donatienne Tyteca. For beginners. For experts. Publications. Highlights. Some cells, such as red blood cells and muscular cells, must resist strong deformation. Disorders of these deformations are the basis of membrane fragility diseases such as spherocytosis (a disease of red blood cells) or Duchenne myopathy (which affectsmuscular cells).
NEIGHBOR-JOINING METHOD The Neighbor-Joining Method. Neighbor-joining (Saitou and Nei, 1987) is a method that is related to the cluster method but does not require the data to be ultrametric. PAM1 MUTATION MATRIX Mutation probability matrix for the evolutionary distance of 1 PAM (i.e., one Accepted Point Mutation per 100 amino acids). ORTHOLOGOUS AND PARALOGOUS GENES What are orthologous and what are paralogous genes ? It is said that: Two genes are to be orthologous if they diverged after a speciationevent,
HARMFUL EFFECTS OF THE PARASITE ON THE HOST Many parasites cause harmful effects to their host, but in most cases these effects are not of such importance that the host is being killed. Such effects comprise: LAURE DUMOUTIER & JEAN-CHRISTOPHE RENAULD Laure Dumoutier & Jean-Christophe Renauld | Institut de Duve. For beginners. For experts. Publications. Highlights. Diseases such as asthma, psoriasis (disease affecting the skin), inflammatory bowel disease or cancer are associated with a dysregulation of the inflammatory response. In our laboratory, we try to improve the understanding of theVASCULAR ANOMALIES
Vascular Anomalies. Involved group members: Miikka Vikkula, Nisha Limaye, Pascal Brouillard, Mustapha Amyere, Ha-Long Nguyen, Laurence Boon, Nicole Revencu Vascular anomalies are localized defects of the blood or lymphatic vasculature that arise during embryonic development and are typically observed at birth or soon after. CELLULAR METABOLISM & MICROENVIRONMENT We use state-of-the-art metabolic analysis techniques in combination with cell and animal models to investigate how metabolites produced by one cell type influence the behavior of the other cells in its environment. The goal of our research is to identify niche-derived metabolic signals important for the maintenance of blood stem cellsand the
ANABELLE DECOTTIGNIES Anabelle Decottignies. For beginners. For experts. Publications. Highlights. In our laboratory, we are interested in understanding the mechanisms that are set up by cancer cells to acquire this “endless youthful” property that ensures indefinite cellular proliferation potential. Understanding these mechanisms is expected to helpidentifying
PIERRE VAN DER BRUGGEN The de Duve Institute has played a key role in demonstrating this concept because the first tumor antigens have been discovered here by the team of Thierry Boon. Pierre van der Bruggen and Catia Traversari were at the forefront. Dozens of these antigens recognized by cytolytic T lymphocytes are now known, and many remain to bediscovered.
LAURENT GATTO
Bioinformatics. 2019; 35 (17):3151-3153. Assessing sub-cellular resolution in spatial proteomics experiments. Gatto L, Breckels LM, Lilley KS. Curr Opin Chem Biol. 2018; 48:123-49. A Bayesian mixture modelling approach for spatial proteomics. Crook OM, Mulvey CM, Kirk PDW, Lilley KS, Gatto L.NISHA LIMAYE
Nat Med. 2008; 14 (11):1236-46. Prevalence and evolutionary origins of autoimmune susceptibility alleles in natural mouse populations. Limaye N, Belobrajdic KA, Wandstrat AE, Bonhomme F, Edwards SV, Wakeland EK. Genes Immun. 2008; 9 (1):61-8. PHD STUDENT DAY, MEI 26, 2021 11:05 Can lipoproteins decorate Escherichia coli’s surface? (Naemi Csoma) 11:25 EVs: actors and markers of thyroid cancers (Ophélie Delcorte). 11:45 Role of hypoxia and HIF-1α in the immunosuppressive tumor microenvironment (Tereza Dvorakova). 12:05 Cardiovirus L proteins-mediated FG-nucleoporins phosphorylation (Belén Lizcano Perret). 12:25 – 12:40 Quizz (winner: Laura Glorieux) EXAMPLE 1 (FILE FORMATS) A multiple alignment then is created using the program ClustalW, which reads various formats such as the NBRF/PIR and Phylip formats for sequence files. Here you see a multiple sequence alignment created by ClustalW in Pileup MSF and in Phylip format. The MSF format allows the easy editing of the alignment by a word processor such as MSWord. Columns where the alignment is ambiguous, or with PHENETICS VERSUS CLADISTICS Phenetics versus Cladistics and the pro's and con's of the various phylogeny inference methods . Phenetics versus Cladistics. Cladistics can be defined as the study of the pathways of evolution. In other words, cladists are interested in such questions as: how many branches there are among a group of organisms; which branch connects to which other branch; and what is the branching sequence. icon-captions-officon-captions-onexpandcollapsemutedpauseicon-restartrewind* Seminars
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The DE DUVE INSTITUTE is a multidisciplinary biomedical research institute hosting several laboratories of the faculty of medicine of UCL (Université catholique de Louvain), as well as the Brussels branch of the Ludwig Institute.LATEST NEWS
The GSK Vaccines Prize of the Royal Academy of Medicine awarded to Sophie Lucas for her work on cancer immunotherapy New pathway to treat cystinosis, a lysosomal storage disease a discovery by Pierre Courtoy and his team 4th de Duve Lecture: Watch the podcast! Carl-Henrik Heldin enlightened us on the TGFβ receptors, possible targets in tumor treatmentFUNDING AGENCIES
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