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PROTEOMICS SERVICE
Drug discovery and development. Toxicological testing. Antibody profiling for study and treatment disease. With years' experience in advanced experiment equipment, Creative Proteomics can provide a variety of proteomics services to assist your scientific research, including: Protein gel and imaging analysis service. Protein identification service. ITRAQ-BASED PROTEOMICS ANALYSIS Creative Proteomics offers iTRAQ protein quantification service suited for unbiased untargeted biomarker discovery. Relative quantification of proteins for biomarker discovery in complex mixtures by mass spectrometry can easily and quickly be achieved using iTRAQ technology. iTRAQ is ideally suited for comparing normal, diseased, and drug-treated samples, time course studies, biologicalGSH AND GSSG
1. Reduced form of glutath (GSH) 2. Oxidized form of glutathione (GSSG) With integrated set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective GSH and GSSGtargeted
OVERVIEW OF BIOINFORMATICS SERVICES Overview of Bioinformatics Services. As an interdisciplinary field, bioinformatics combines computer science, statistics and life sciences together, to develop algorithms and professional software tools for mining and interpreting the tremendous biological data, generated in recent booming high throughput T2 & HT2 TOXIN CONTAMINATION ANALYSIS Liquid chromatography coupled with mass spectrometry (LC-MS) LC-MS is a widely used and well established method for the quantification of T2 and HT2 toxins. The method offers low limit of detection and high accuracy. The median limit of quantification (LOQ) is in the range of 10 µg/kg. We also maintain high quality assurance for the analysis.HEXOSYLCERAMIDE
Recently, plasma hexosylceramide were also found to be significantly regulated in chronic hepatitis C, which make them good biomarkers for the disease. The advantages of LC-MS/MS method include relatively higher sensitivity and selectivity and short run times. With experienced scientists at Creative Proteomics, we have developed areliable and
FAR UV CIRCULAR DICHROISM SPECTROSCOPY ANALYSIS Creative Proteomics' analytical scientists can provide a clear and concise written report of the spectrum data of the far ultraviolet circular dichroism analysis to help customers analyze the secondary structure of the protein. We can also provide you with a one-stop service from sample preparation, purity analysis to circular dichroismanalysis.
THE PRINCIPLE, CHARACTERISTICS AND APPLICATION OF PEPTIDE The principle of TOF is that ions are accelerated to fly through the flight duct under the action of an electric field, and the ions are detected based on the time of flight to the detector. MALDI-TOF-MS has the characteristics of high sensitivity, high accuracy, and highresolution.
METAGENOMIC SEQUENCING Figure 1. Summary of a metagenomics workflow (Quince 2017) Creative Proteomics, specialized in omics services, with the well-rounded gut flora platform, provides one-stop shotgun metagenomic sequencing and data analysis services customized for your research into gut microbiota as to aspects such as host-pathogen interactions, bacterial disease mechanisms and how microbial communities interact. PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Drug discovery and development. Toxicological testing. Antibody profiling for study and treatment disease. With years' experience in advanced experiment equipment, Creative Proteomics can provide a variety of proteomics services to assist your scientific research, including: Protein gel and imaging analysis service. Protein identification service. ITRAQ-BASED PROTEOMICS ANALYSIS Creative Proteomics offers iTRAQ protein quantification service suited for unbiased untargeted biomarker discovery. Relative quantification of proteins for biomarker discovery in complex mixtures by mass spectrometry can easily and quickly be achieved using iTRAQ technology. iTRAQ is ideally suited for comparing normal, diseased, and drug-treated samples, time course studies, biologicalGSH AND GSSG
1. Reduced form of glutath (GSH) 2. Oxidized form of glutathione (GSSG) With integrated set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective GSH and GSSGtargeted
OVERVIEW OF BIOINFORMATICS SERVICES Overview of Bioinformatics Services. As an interdisciplinary field, bioinformatics combines computer science, statistics and life sciences together, to develop algorithms and professional software tools for mining and interpreting the tremendous biological data, generated in recent booming high throughput T2 & HT2 TOXIN CONTAMINATION ANALYSIS Liquid chromatography coupled with mass spectrometry (LC-MS) LC-MS is a widely used and well established method for the quantification of T2 and HT2 toxins. The method offers low limit of detection and high accuracy. The median limit of quantification (LOQ) is in the range of 10 µg/kg. We also maintain high quality assurance for the analysis.HEXOSYLCERAMIDE
Recently, plasma hexosylceramide were also found to be significantly regulated in chronic hepatitis C, which make them good biomarkers for the disease. The advantages of LC-MS/MS method include relatively higher sensitivity and selectivity and short run times. With experienced scientists at Creative Proteomics, we have developed areliable and
FAR UV CIRCULAR DICHROISM SPECTROSCOPY ANALYSIS Creative Proteomics' analytical scientists can provide a clear and concise written report of the spectrum data of the far ultraviolet circular dichroism analysis to help customers analyze the secondary structure of the protein. We can also provide you with a one-stop service from sample preparation, purity analysis to circular dichroismanalysis.
THE PRINCIPLE, CHARACTERISTICS AND APPLICATION OF PEPTIDE The principle of TOF is that ions are accelerated to fly through the flight duct under the action of an electric field, and the ions are detected based on the time of flight to the detector. MALDI-TOF-MS has the characteristics of high sensitivity, high accuracy, and highresolution.
METAGENOMIC SEQUENCING Figure 1. Summary of a metagenomics workflow (Quince 2017) Creative Proteomics, specialized in omics services, with the well-rounded gut flora platform, provides one-stop shotgun metagenomic sequencing and data analysis services customized for your research into gut microbiota as to aspects such as host-pathogen interactions, bacterial disease mechanisms and how microbial communities interact. SERVICES - CREATIVE PROTEOMICS Metabolomics Services. Metabolomics is the study of the small molecule metabolic products (the metabolome) of a biological system. Based on advanced techniques (such as MS, NMR, etc.), we can provide targeted and untargeted metabolomics services, lipidomics services, metabolicflux analysis, etc.
OVERVIEW OF BIOINFORMATICS SERVICES Overview of Bioinformatics Services. As an interdisciplinary field, bioinformatics combines computer science, statistics and life sciences together, to develop algorithms and professional software tools for mining and interpreting the tremendous biological data, generated in recent booming high throughputGSH AND GSSG
1. Reduced form of glutath (GSH) 2. Oxidized form of glutathione (GSSG) With integrated set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective GSH and GSSGtargeted
MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of 1D SDS-PAGE AND IEF SERVICE 1D SDS-PAGE. Polyacrylamide gel electrophoresis (PAGE) is one of the most frequently employed techniques for separating macromolecules including DNA, RNA, and proteins. Electrophoresis is in general the process of applying an electric field to move charged molecules through a solution. In this technique, the mobility of a chargedmolecule is
MS/MS BASED SEQUENCING OF PEPTIDES MS/MS based Sequencing of Peptides. Analytical characterization of purified proteins, in particular recombinant proteins for drug discovery and development, requires confirmation of protein sequence. N- and C-terminal Protein Sequencing can be used for verification of protein terminals to investigate protein degradation products andenzyme
ABSOLUTE QUANTIFICATION (AQUA) Absolute Quantification (AQUA) Absolute Quantification is a targeted quantitative proteomics technique that exhibits robust efficacy and is being increasingly utilized for a wide variety of quantitative proteomics studies. AQUA strategy is for the absolute quantification(AQUA
POLYSACCHARIDE ANALYSIS Polysaccharide Analysis. Polysaccharides form a diverse and complex family of biological macromolecules. They are polymeric carbohydrate molecules composed of long chains of monosaccharide units joined together by glycosidic linkages. It gives the constituent monosaccharides or oligosaccharides during hydrolysis. RHAMNOLIPIDS ANALYSIS SERVICE Rhamnolipids are one of the most extensively studied biosurfactants and offer a convincing application potential. Creative Proteomics has developed a reliable and reproducible method using highly sensitive LC-MS/MS method for the rapid identification and quantification of rhamnolipids in yeast, which can satisfy the needs of academic and industrial study in your lab.STILBENES ANALYSIS
Sample Requirements. 1. Fresh plant tissues from leaf, flower, stem, root, seed, or fruit: >1 g. Provide young plant tissues for the best results. Samples should be frozen in liquid nitrogen immediately after collection, and then transferred to -80°C for storage. PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Drug discovery and development. Toxicological testing. Antibody profiling for study and treatment disease. With years' experience in advanced experiment equipment, Creative Proteomics can provide a variety of proteomics services to assist your scientific research, including: Protein gel and imaging analysis service. Protein identification service. ITRAQ-BASED PROTEOMICS ANALYSIS Creative Proteomics offers iTRAQ protein quantification service suited for unbiased untargeted biomarker discovery. Relative quantification of proteins for biomarker discovery in complex mixtures by mass spectrometry can easily and quickly be achieved using iTRAQ technology. iTRAQ is ideally suited for comparing normal, diseased, and drug-treated samples, time course studies, biologicalGSH AND GSSG
1. Reduced form of glutath (GSH) 2. Oxidized form of glutathione (GSSG) With integrated set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective GSH and GSSGtargeted
OVERVIEW OF BIOINFORMATICS SERVICES Overview of Bioinformatics Services. As an interdisciplinary field, bioinformatics combines computer science, statistics and life sciences together, to develop algorithms and professional software tools for mining and interpreting the tremendous biological data, generated in recent booming high throughput T2 & HT2 TOXIN CONTAMINATION ANALYSIS Liquid chromatography coupled with mass spectrometry (LC-MS) LC-MS is a widely used and well established method for the quantification of T2 and HT2 toxins. The method offers low limit of detection and high accuracy. The median limit of quantification (LOQ) is in the range of 10 µg/kg. We also maintain high quality assurance for the analysis.HEXOSYLCERAMIDE
Recently, plasma hexosylceramide were also found to be significantly regulated in chronic hepatitis C, which make them good biomarkers for the disease. The advantages of LC-MS/MS method include relatively higher sensitivity and selectivity and short run times. With experienced scientists at Creative Proteomics, we have developed areliable and
FAR UV CIRCULAR DICHROISM SPECTROSCOPY ANALYSIS Creative Proteomics' analytical scientists can provide a clear and concise written report of the spectrum data of the far ultraviolet circular dichroism analysis to help customers analyze the secondary structure of the protein. We can also provide you with a one-stop service from sample preparation, purity analysis to circular dichroismanalysis.
THE PRINCIPLE, CHARACTERISTICS AND APPLICATION OF PEPTIDE The principle of TOF is that ions are accelerated to fly through the flight duct under the action of an electric field, and the ions are detected based on the time of flight to the detector. MALDI-TOF-MS has the characteristics of high sensitivity, high accuracy, and highresolution.
METAGENOMIC SEQUENCING Figure 1. Summary of a metagenomics workflow (Quince 2017) Creative Proteomics, specialized in omics services, with the well-rounded gut flora platform, provides one-stop shotgun metagenomic sequencing and data analysis services customized for your research into gut microbiota as to aspects such as host-pathogen interactions, bacterial disease mechanisms and how microbial communities interact. PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Drug discovery and development. Toxicological testing. Antibody profiling for study and treatment disease. With years' experience in advanced experiment equipment, Creative Proteomics can provide a variety of proteomics services to assist your scientific research, including: Protein gel and imaging analysis service. Protein identification service. ITRAQ-BASED PROTEOMICS ANALYSIS Creative Proteomics offers iTRAQ protein quantification service suited for unbiased untargeted biomarker discovery. Relative quantification of proteins for biomarker discovery in complex mixtures by mass spectrometry can easily and quickly be achieved using iTRAQ technology. iTRAQ is ideally suited for comparing normal, diseased, and drug-treated samples, time course studies, biologicalGSH AND GSSG
1. Reduced form of glutath (GSH) 2. Oxidized form of glutathione (GSSG) With integrated set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective GSH and GSSGtargeted
OVERVIEW OF BIOINFORMATICS SERVICES Overview of Bioinformatics Services. As an interdisciplinary field, bioinformatics combines computer science, statistics and life sciences together, to develop algorithms and professional software tools for mining and interpreting the tremendous biological data, generated in recent booming high throughput T2 & HT2 TOXIN CONTAMINATION ANALYSIS Liquid chromatography coupled with mass spectrometry (LC-MS) LC-MS is a widely used and well established method for the quantification of T2 and HT2 toxins. The method offers low limit of detection and high accuracy. The median limit of quantification (LOQ) is in the range of 10 µg/kg. We also maintain high quality assurance for the analysis.HEXOSYLCERAMIDE
Recently, plasma hexosylceramide were also found to be significantly regulated in chronic hepatitis C, which make them good biomarkers for the disease. The advantages of LC-MS/MS method include relatively higher sensitivity and selectivity and short run times. With experienced scientists at Creative Proteomics, we have developed areliable and
FAR UV CIRCULAR DICHROISM SPECTROSCOPY ANALYSIS Creative Proteomics' analytical scientists can provide a clear and concise written report of the spectrum data of the far ultraviolet circular dichroism analysis to help customers analyze the secondary structure of the protein. We can also provide you with a one-stop service from sample preparation, purity analysis to circular dichroismanalysis.
THE PRINCIPLE, CHARACTERISTICS AND APPLICATION OF PEPTIDE The principle of TOF is that ions are accelerated to fly through the flight duct under the action of an electric field, and the ions are detected based on the time of flight to the detector. MALDI-TOF-MS has the characteristics of high sensitivity, high accuracy, and highresolution.
METAGENOMIC SEQUENCING Figure 1. Summary of a metagenomics workflow (Quince 2017) Creative Proteomics, specialized in omics services, with the well-rounded gut flora platform, provides one-stop shotgun metagenomic sequencing and data analysis services customized for your research into gut microbiota as to aspects such as host-pathogen interactions, bacterial disease mechanisms and how microbial communities interact. SERVICES - CREATIVE PROTEOMICS Metabolomics Services. Metabolomics is the study of the small molecule metabolic products (the metabolome) of a biological system. Based on advanced techniques (such as MS, NMR, etc.), we can provide targeted and untargeted metabolomics services, lipidomics services, metabolicflux analysis, etc.
OVERVIEW OF BIOINFORMATICS SERVICES Overview of Bioinformatics Services. As an interdisciplinary field, bioinformatics combines computer science, statistics and life sciences together, to develop algorithms and professional software tools for mining and interpreting the tremendous biological data, generated in recent booming high throughputGSH AND GSSG
1. Reduced form of glutath (GSH) 2. Oxidized form of glutathione (GSSG) With integrated set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective GSH and GSSGtargeted
MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of 1D SDS-PAGE AND IEF SERVICE 1D SDS-PAGE. Polyacrylamide gel electrophoresis (PAGE) is one of the most frequently employed techniques for separating macromolecules including DNA, RNA, and proteins. Electrophoresis is in general the process of applying an electric field to move charged molecules through a solution. In this technique, the mobility of a chargedmolecule is
MS/MS BASED SEQUENCING OF PEPTIDES MS/MS based Sequencing of Peptides. Analytical characterization of purified proteins, in particular recombinant proteins for drug discovery and development, requires confirmation of protein sequence. N- and C-terminal Protein Sequencing can be used for verification of protein terminals to investigate protein degradation products andenzyme
ABSOLUTE QUANTIFICATION (AQUA) Absolute Quantification (AQUA) Absolute Quantification is a targeted quantitative proteomics technique that exhibits robust efficacy and is being increasingly utilized for a wide variety of quantitative proteomics studies. AQUA strategy is for the absolute quantification(AQUA
POLYSACCHARIDE ANALYSIS Polysaccharide Analysis. Polysaccharides form a diverse and complex family of biological macromolecules. They are polymeric carbohydrate molecules composed of long chains of monosaccharide units joined together by glycosidic linkages. It gives the constituent monosaccharides or oligosaccharides during hydrolysis. RHAMNOLIPIDS ANALYSIS SERVICE Rhamnolipids are one of the most extensively studied biosurfactants and offer a convincing application potential. Creative Proteomics has developed a reliable and reproducible method using highly sensitive LC-MS/MS method for the rapid identification and quantification of rhamnolipids in yeast, which can satisfy the needs of academic and industrial study in your lab.STILBENES ANALYSIS
Sample Requirements. 1. Fresh plant tissues from leaf, flower, stem, root, seed, or fruit: >1 g. Provide young plant tissues for the best results. Samples should be frozen in liquid nitrogen immediately after collection, and then transferred to -80°C for storage. PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies. PROTEIN LIGAND BINDING SITE PREDICTION SERVICE Interaction with a ligand molecule is very important for many proteins to carry out their biological function. This interaction is usually specific, not only in terms of the protein molecules involved in the interaction, but also in the location (i.e., the ligand binding site) in which this interaction happens. MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of TOP-DOWN PROTEOMICS VS BOTTOM-UP PROTEOMICS Protein research is one of the most challenging topics in analytical chemistry. Initial protein research focused on developing techniques capable of isolating and INTRODUCTION TO GAS CHROMATOGRAPHY—PRINCIPLES What is gas chromatography ?. Chromatography is a technique that separates components in a mixture by the difference in partitioning behavior between mobile and stationary phases. A BRIEF INTRODUCTION TO PEPTIDE MAPPING The definition and principle of peptide mapping . The molecular weight and amino acid composition of the proteins and peptides, as well as the specific endonucleases to act on specific peptide chain, are used in Peptide mapping.Peptides are cut into small fragments byendonucleases.
T2 & HT2 TOXIN CONTAMINATION ANALYSIS T2 toxin and its deacetylated form HT2 toxin are a group of compounds known as trichothecenes that are produced by the fungi of Fusarium species.. Figure 1. Chemical structure of T2 toxin and HT2 toxin and related contaminated foods INTERPRETATION OF MASS SPECTRA—EI-MS Electron ionization (EI) is an ionization method that is mature and most prevalently used to determine the structure of unknown compounds. Once the mass spectrum of a sample is obtained, how do we interpret the data to results we can recognize? 1. Identification of molecularion peaks
TWO SOFT IONIZATION TECHNIQUES—EI AND MALDI In order to advance along with biochemistry, mass spectrometry is constantly improved and innovated, including a variety of soft ionization technologies, such as the fast atom bombardment (FAB), field desorption ionization (FD), secondary ion mass spectrometry (SIMS), plasma desorption (PD), laser desorption (LD), electrospray ionization (ESI), thermal spray (TSI), and matrix-assisted laser BIOINFORMATICS ANALYSIS-NETWORK ANALYSIS BIOINFOMATIC ANALYSIS NETWORK ANALYSIS Protein-Protein Interactions Analysis Database of Interacting Proteins (DIP) Reactome STRING Ingenuity Pathway Analysis PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies. PROTEIN LIGAND BINDING SITE PREDICTION SERVICE Interaction with a ligand molecule is very important for many proteins to carry out their biological function. This interaction is usually specific, not only in terms of the protein molecules involved in the interaction, but also in the location (i.e., the ligand binding site) in which this interaction happens. MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of TOP-DOWN PROTEOMICS VS BOTTOM-UP PROTEOMICS Protein research is one of the most challenging topics in analytical chemistry. Initial protein research focused on developing techniques capable of isolating and INTRODUCTION TO GAS CHROMATOGRAPHY—PRINCIPLES What is gas chromatography ?. Chromatography is a technique that separates components in a mixture by the difference in partitioning behavior between mobile and stationary phases. A BRIEF INTRODUCTION TO PEPTIDE MAPPING The definition and principle of peptide mapping . The molecular weight and amino acid composition of the proteins and peptides, as well as the specific endonucleases to act on specific peptide chain, are used in Peptide mapping.Peptides are cut into small fragments byendonucleases.
T2 & HT2 TOXIN CONTAMINATION ANALYSIS T2 toxin and its deacetylated form HT2 toxin are a group of compounds known as trichothecenes that are produced by the fungi of Fusarium species.. Figure 1. Chemical structure of T2 toxin and HT2 toxin and related contaminated foods INTERPRETATION OF MASS SPECTRA—EI-MS Electron ionization (EI) is an ionization method that is mature and most prevalently used to determine the structure of unknown compounds. Once the mass spectrum of a sample is obtained, how do we interpret the data to results we can recognize? 1. Identification of molecularion peaks
TWO SOFT IONIZATION TECHNIQUES—EI AND MALDI In order to advance along with biochemistry, mass spectrometry is constantly improved and innovated, including a variety of soft ionization technologies, such as the fast atom bombardment (FAB), field desorption ionization (FD), secondary ion mass spectrometry (SIMS), plasma desorption (PD), laser desorption (LD), electrospray ionization (ESI), thermal spray (TSI), and matrix-assisted laser BIOINFORMATICS ANALYSIS-NETWORK ANALYSIS BIOINFOMATIC ANALYSIS NETWORK ANALYSIS Protein-Protein Interactions Analysis Database of Interacting Proteins (DIP) Reactome STRING Ingenuity Pathway Analysis PROTEIN LIGAND BINDING SITE PREDICTION SERVICE Interaction with a ligand molecule is very important for many proteins to carry out their biological function. This interaction is usually specific, not only in terms of the protein molecules involved in the interaction, but also in the location (i.e., the ligand binding site) in which this interaction happens. TOP-DOWN PROTEOMICS VS BOTTOM-UP PROTEOMICS Protein research is one of the most challenging topics in analytical chemistry. Initial protein research focused on developing techniques capable of isolating and KOG ANNOTATION ANALYSIS SERVICE EuKaryotic Orthologous Groups, or KOGs, is a eukaryote-specific version of the Clusters of Orthologous Groups (COGs) for the identification of ortholog and paralog proteins. FAR UV CIRCULAR DICHROISM SPECTROSCOPY ANALYSIS Far UV Circular Dichroism Spectroscopy Analysis. Circular dichroism (CD) spectroscopy is a fast, simple, and accurate method for studying protein structures in dilute solutions. LABEL-BASED PROTEIN QUANTIFICATION TECHNOLOGY—ITRAQ, TMT The dynamic changes of proteome abundance in cells have an important impact on various life processes. For example, the occurrence and development of many diseases is often accompanied by abnormal expression of certain proteins. TARGETED PROTEOMICS VS DISCOVERY PROTEOMICS PROTEOMICS TARGETED V S DISCOVERY targeted and discovery proteomics At present, strategies for proteomics research can be divided into discovery proteomics and targeted proteomics. INTERPRETATION OF MASS SPECTRA—EI-MS Electron ionization (EI) is an ionization method that is mature and most prevalently used to determine the structure of unknown compounds. Once the mass spectrum of a sample is obtained, how do we interpret the data to results we can recognize? 1. Identification of molecularion peaks
ISOELECTRIC POINT DETERMINATION WITH IEF Isoelectric Point Determination with IEF. Isoelectric point (pI) is the pH value at which the molecule carries no net electrical charges, which is one of important characters for zwitterionic molecules such as aimno acids, peptides, and proteins.Since pI can be a critical factor to affect the overall pharmacokinetic (PK) behavior, it is necessary to assess pI during drug development. ISOELECTRIC POINT DETERMINATION WITH CIEF Isoelectric Point Determination with cIEF. Isoelectric point (pI) is the pH value at which the overall net charge of a macromolecule equals zero. pI is one of important physico-chemical parameters to influence overall pharmacokinetic behavior, so that it's necessary to assess pI during drug development.. pI can be determined by various experiments, including isoelectric focusing experiments CONSTRUCTION OF CELL AND ANIMAL MODELS The tumor-bearing mouse models that we can provide are mainly divided into two types. One is to inoculate human or mouse-derived cell lines into immunodeficient mice, called CDX models, and the other is to tumours derived from patients. PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Drug discovery and development. Toxicological testing. Antibody profiling for study and treatment disease. With years' experience in advanced experiment equipment, Creative Proteomics can provide a variety of proteomics services to assist your scientific research, including: Protein gel and imaging analysis service. Protein identification service. MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of A BRIEF INTRODUCTION TO PEPTIDE MAPPING The procedure of peptide mapping. 1. Obtain protein samples. 2. Use 6 proteases (Trypsin, Chymotrypsin, Asp-N, Glu-C, Lys-C, and Lys-N) to digest and identify target proteins. Using trypsin to digest the protein during the process of protein sample identification, the FREE FATTY ACIDS (FFAS) ANALYSIS SERVICE Free Fatty Acids (FFAs) Analysis Service. In animals, many of the dietary lipids are hydrolyzed to free fatty acids (FFAs) before being absorbed and utilized further for lipid synthesis. Lipids can be hydrolyzed to FFAs in tissues by lipolytic enzymes, such as hormonesensitive lipase, lipoprotein lipase, and phospholipases A andC, before they
BIOMOLECULAR INTERACTION ANALYSIS With advanced Biacore instrument, various sensor chips and experienced technical staff, Creative Proteomics can provide cost-effective characterization service of biomolecular interactions. * For Research Use Only. Not for use in diagnostic procedures. Our customer service representatives are available 24 hours a day, 7 days a week. Inquiry. LABEL-BASED PROTEIN QUANTIFICATION TECHNOLOGY—ITRAQ, TMT TMT is a peptide in vitro labeling technology developed by Thermo Scientific in the United States. This technology can use up to 10 isotope labels to label the amino groups of polypeptides. After LC-MS / MS analysis, the relative content of proteins in 10 different samples can be compared at the same time.ISOELECTRIC POINT
The isoelectric point (pI) is the pH at which a particular molecule carries no net electrical charge. Because the specific mutations, truncation or post-translational modifications can change the pI of the natural proteins. The net charge on the molecule is affected both by its own pI, and pH of the surrounding environment, And the proteinscan
INTRODUCTION TO GAS CHROMATOGRAPHY—PRINCIPLES What is gas chromatography ?. Chromatography is a technique that separates components in a mixture by the difference in partitioning behavior between mobile and stationary phases. ELECTROSPRAY IONIZATION Electrospray Ionization. Electrospray ionization (ESI) is a technique to generate ions for mass spectrometry using electrospray by applying a high voltage to a liquid to produce an aerosol. Due to relatively fragile biomacromolecules, their structures are easily destroyed during the process of dissociation and ionization. PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Drug discovery and development. Toxicological testing. Antibody profiling for study and treatment disease. With years' experience in advanced experiment equipment, Creative Proteomics can provide a variety of proteomics services to assist your scientific research, including: Protein gel and imaging analysis service. Protein identification service. MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of A BRIEF INTRODUCTION TO PEPTIDE MAPPING The procedure of peptide mapping. 1. Obtain protein samples. 2. Use 6 proteases (Trypsin, Chymotrypsin, Asp-N, Glu-C, Lys-C, and Lys-N) to digest and identify target proteins. Using trypsin to digest the protein during the process of protein sample identification, the FREE FATTY ACIDS (FFAS) ANALYSIS SERVICE Free Fatty Acids (FFAs) Analysis Service. In animals, many of the dietary lipids are hydrolyzed to free fatty acids (FFAs) before being absorbed and utilized further for lipid synthesis. Lipids can be hydrolyzed to FFAs in tissues by lipolytic enzymes, such as hormonesensitive lipase, lipoprotein lipase, and phospholipases A andC, before they
BIOMOLECULAR INTERACTION ANALYSIS With advanced Biacore instrument, various sensor chips and experienced technical staff, Creative Proteomics can provide cost-effective characterization service of biomolecular interactions. * For Research Use Only. Not for use in diagnostic procedures. Our customer service representatives are available 24 hours a day, 7 days a week. Inquiry. LABEL-BASED PROTEIN QUANTIFICATION TECHNOLOGY—ITRAQ, TMT TMT is a peptide in vitro labeling technology developed by Thermo Scientific in the United States. This technology can use up to 10 isotope labels to label the amino groups of polypeptides. After LC-MS / MS analysis, the relative content of proteins in 10 different samples can be compared at the same time.ISOELECTRIC POINT
The isoelectric point (pI) is the pH at which a particular molecule carries no net electrical charge. Because the specific mutations, truncation or post-translational modifications can change the pI of the natural proteins. The net charge on the molecule is affected both by its own pI, and pH of the surrounding environment, And the proteinscan
INTRODUCTION TO GAS CHROMATOGRAPHY—PRINCIPLES What is gas chromatography ?. Chromatography is a technique that separates components in a mixture by the difference in partitioning behavior between mobile and stationary phases. ELECTROSPRAY IONIZATION Electrospray Ionization. Electrospray ionization (ESI) is a technique to generate ions for mass spectrometry using electrospray by applying a high voltage to a liquid to produce an aerosol. Due to relatively fragile biomacromolecules, their structures are easily destroyed during the process of dissociation and ionization.PROTEIN ARRAY
Protein microarray is a powerful assay system that contains hundreds of molecules on one plate, including cytokines, phosphatases, receptors, and other proteins, which enables the characterization of hundreds of thousands of proteins in a highly parallel and high-throughput manner. GO ANNOTATION ANALYSIS SERVICE GO Annotation Analysis Service at Creative Proteomics could help your research with: Maintain and develop its controlled vocabulary of gene and gene product attributes. Assimilate and disseminate annotation data. Provide tools for easy access to all aspects of the data, enable functional interpretation of experimental data. PTM CROSSTALK ANALYSIS SERVICE The advent of highly sensitive MS-based strategies for large-scale PTM analysis substantially improved our knowledge about PTM and the co-occurrence/crosstalk of PTMs. As one of the leading omics industry company in the world, we are open to help you with TM Crosstalk Analysis Service. Protein function is largely destined bythree-dimensional
N-TERMINAL SEQUENCING ANALYSIS SERVICE The workflow of the N-terminal peptide sequencing via Edman degradation (Yun S.H et al. 2019).. 2) De novo N-terminal peptide sequencing by Tandem MS This technology is mainly through the use of fluorescent reagents to selectively label the N-terminal α-amino group of the protein, while using trypsin for protein digestion, with the help of LC-MS / MS system and Fluorescence detector performs UNTARGETED METABOLOMICS It also can provide you reliable metabolite identification. With integrated a set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective Untargeted Metabolomics asbelow. Serum
MALDI-TOF-MS INTACT PROTEIN ANALYSIS MALDI-TOF-MS Intact Protein Analysis. The development and quality assessment of biopharmaceuticals, especially protein and peptide drugs, require a series of analytical techniques to assess the integrity of bioactive molecules during formulation andadministration.
OPLS-DA SERVICE
OPLS-DA Service. Orthogonal partial least squares discriminant analysis (OPLS-DA) was introduced as an improvement of the PLS-DA approach to discriminate two or more groups (classes) using multivariate data. In OPLS-DA, a regression model is constructed between the multivariate data and a response variable that only contains class information.ISOELECTRIC POINT
The isoelectric point (pI) is the pH at which a particular molecule carries no net electrical charge. Because the specific mutations, truncation or post-translational modifications can change the pI of the natural proteins. The net charge on the molecule is affected both by its own pI, and pH of the surrounding environment, And the proteinscan
ELECTROSPRAY IONIZATION Electrospray Ionization. Electrospray ionization (ESI) is a technique to generate ions for mass spectrometry using electrospray by applying a high voltage to a liquid to produce an aerosol. Due to relatively fragile biomacromolecules, their structures are easily destroyed during the process of dissociation and ionization. Q EXACTIVE HYBRID QUADRUPOLE-ORBITRAP MASS SPECTROMETER The Features of Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer. The resolution up to 140,000 to see more peaks in samples and it can improve results reliability when analyzing samples in complex matrices. Fast scan-to-scan polarity switching in PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Drug discovery and development. Toxicological testing. Antibody profiling for study and treatment disease. With years' experience in advanced experiment equipment, Creative Proteomics can provide a variety of proteomics services to assist your scientific research, including: Protein gel and imaging analysis service. Protein identification service. MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of A BRIEF INTRODUCTION TO PEPTIDE MAPPING The procedure of peptide mapping. 1. Obtain protein samples. 2. Use 6 proteases (Trypsin, Chymotrypsin, Asp-N, Glu-C, Lys-C, and Lys-N) to digest and identify target proteins. Using trypsin to digest the protein during the process of protein sample identification, the FREE FATTY ACIDS (FFAS) ANALYSIS SERVICE Free Fatty Acids (FFAs) Analysis Service. In animals, many of the dietary lipids are hydrolyzed to free fatty acids (FFAs) before being absorbed and utilized further for lipid synthesis. Lipids can be hydrolyzed to FFAs in tissues by lipolytic enzymes, such as hormonesensitive lipase, lipoprotein lipase, and phospholipases A andC, before they
BIOMOLECULAR INTERACTION ANALYSIS With advanced Biacore instrument, various sensor chips and experienced technical staff, Creative Proteomics can provide cost-effective characterization service of biomolecular interactions. * For Research Use Only. Not for use in diagnostic procedures. Our customer service representatives are available 24 hours a day, 7 days a week. Inquiry. LABEL-BASED PROTEIN QUANTIFICATION TECHNOLOGY—ITRAQ, TMT TMT is a peptide in vitro labeling technology developed by Thermo Scientific in the United States. This technology can use up to 10 isotope labels to label the amino groups of polypeptides. After LC-MS / MS analysis, the relative content of proteins in 10 different samples can be compared at the same time. PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Drug discovery and development. Toxicological testing. Antibody profiling for study and treatment disease. With years' experience in advanced experiment equipment, Creative Proteomics can provide a variety of proteomics services to assist your scientific research, including: Protein gel and imaging analysis service. Protein identification service. MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of A BRIEF INTRODUCTION TO PEPTIDE MAPPING The procedure of peptide mapping. 1. Obtain protein samples. 2. Use 6 proteases (Trypsin, Chymotrypsin, Asp-N, Glu-C, Lys-C, and Lys-N) to digest and identify target proteins. Using trypsin to digest the protein during the process of protein sample identification, the FREE FATTY ACIDS (FFAS) ANALYSIS SERVICE Free Fatty Acids (FFAs) Analysis Service. In animals, many of the dietary lipids are hydrolyzed to free fatty acids (FFAs) before being absorbed and utilized further for lipid synthesis. Lipids can be hydrolyzed to FFAs in tissues by lipolytic enzymes, such as hormonesensitive lipase, lipoprotein lipase, and phospholipases A andC, before they
BIOMOLECULAR INTERACTION ANALYSIS With advanced Biacore instrument, various sensor chips and experienced technical staff, Creative Proteomics can provide cost-effective characterization service of biomolecular interactions. * For Research Use Only. Not for use in diagnostic procedures. Our customer service representatives are available 24 hours a day, 7 days a week. Inquiry. LABEL-BASED PROTEIN QUANTIFICATION TECHNOLOGY—ITRAQ, TMT TMT is a peptide in vitro labeling technology developed by Thermo Scientific in the United States. This technology can use up to 10 isotope labels to label the amino groups of polypeptides. After LC-MS / MS analysis, the relative content of proteins in 10 different samples can be compared at the same time.ISOELECTRIC POINT
The isoelectric point (pI) is the pH at which a particular molecule carries no net electrical charge. Because the specific mutations, truncation or post-translational modifications can change the pI of the natural proteins. The net charge on the molecule is affected both by its own pI, and pH of the surrounding environment, And the proteinscan
INTRODUCTION TO GAS CHROMATOGRAPHY—PRINCIPLES What is gas chromatography ?. Chromatography is a technique that separates components in a mixture by the difference in partitioning behavior between mobile and stationary phases. ELECTROSPRAY IONIZATION Electrospray Ionization. Electrospray ionization (ESI) is a technique to generate ions for mass spectrometry using electrospray by applying a high voltage to a liquid to produce an aerosol. Due to relatively fragile biomacromolecules, their structures are easily destroyed during the process of dissociation and ionization.PROTEIN ARRAY
Protein microarray is a powerful assay system that contains hundreds of molecules on one plate, including cytokines, phosphatases, receptors, and other proteins, which enables the characterization of hundreds of thousands of proteins in a highly parallel and high-throughput manner. GO ANNOTATION ANALYSIS SERVICE GO Annotation Analysis Service at Creative Proteomics could help your research with: Maintain and develop its controlled vocabulary of gene and gene product attributes. Assimilate and disseminate annotation data. Provide tools for easy access to all aspects of the data, enable functional interpretation of experimental data. PTM CROSSTALK ANALYSIS SERVICE The advent of highly sensitive MS-based strategies for large-scale PTM analysis substantially improved our knowledge about PTM and the co-occurrence/crosstalk of PTMs. As one of the leading omics industry company in the world, we are open to help you with TM Crosstalk Analysis Service. Protein function is largely destined bythree-dimensional
N-TERMINAL SEQUENCING ANALYSIS SERVICE The workflow of the N-terminal peptide sequencing via Edman degradation (Yun S.H et al. 2019).. 2) De novo N-terminal peptide sequencing by Tandem MS This technology is mainly through the use of fluorescent reagents to selectively label the N-terminal α-amino group of the protein, while using trypsin for protein digestion, with the help of LC-MS / MS system and Fluorescence detector performs UNTARGETED METABOLOMICS It also can provide you reliable metabolite identification. With integrated a set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective Untargeted Metabolomics asbelow. Serum
MALDI-TOF-MS INTACT PROTEIN ANALYSIS MALDI-TOF-MS Intact Protein Analysis. The development and quality assessment of biopharmaceuticals, especially protein and peptide drugs, require a series of analytical techniques to assess the integrity of bioactive molecules during formulation andadministration.
OPLS-DA SERVICE
OPLS-DA Service. Orthogonal partial least squares discriminant analysis (OPLS-DA) was introduced as an improvement of the PLS-DA approach to discriminate two or more groups (classes) using multivariate data. In OPLS-DA, a regression model is constructed between the multivariate data and a response variable that only contains class information.ISOELECTRIC POINT
The isoelectric point (pI) is the pH at which a particular molecule carries no net electrical charge. Because the specific mutations, truncation or post-translational modifications can change the pI of the natural proteins. The net charge on the molecule is affected both by its own pI, and pH of the surrounding environment, And the proteinscan
ELECTROSPRAY IONIZATION Electrospray Ionization. Electrospray ionization (ESI) is a technique to generate ions for mass spectrometry using electrospray by applying a high voltage to a liquid to produce an aerosol. Due to relatively fragile biomacromolecules, their structures are easily destroyed during the process of dissociation and ionization. Q EXACTIVE HYBRID QUADRUPOLE-ORBITRAP MASS SPECTROMETER The Features of Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer. The resolution up to 140,000 to see more peaks in samples and it can improve results reliability when analyzing samples in complex matrices. Fast scan-to-scan polarity switching in PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Drug discovery and development. Toxicological testing. Antibody profiling for study and treatment disease. With years' experience in advanced experiment equipment, Creative Proteomics can provide a variety of proteomics services to assist your scientific research, including: Protein gel and imaging analysis service. Protein identification service. MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of A BRIEF INTRODUCTION TO PEPTIDE MAPPING The procedure of peptide mapping. 1. Obtain protein samples. 2. Use 6 proteases (Trypsin, Chymotrypsin, Asp-N, Glu-C, Lys-C, and Lys-N) to digest and identify target proteins. Using trypsin to digest the protein during the process of protein sample identification, the PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Drug discovery and development. Toxicological testing. Antibody profiling for study and treatment disease. With years' experience in advanced experiment equipment, Creative Proteomics can provide a variety of proteomics services to assist your scientific research, including: Protein gel and imaging analysis service. Protein identification service. MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of A BRIEF INTRODUCTION TO PEPTIDE MAPPING The procedure of peptide mapping. 1. Obtain protein samples. 2. Use 6 proteases (Trypsin, Chymotrypsin, Asp-N, Glu-C, Lys-C, and Lys-N) to digest and identify target proteins. Using trypsin to digest the protein during the process of protein sample identification, the FREE FATTY ACIDS (FFAS) ANALYSIS SERVICE Free Fatty Acids (FFAs) Analysis Service. In animals, many of the dietary lipids are hydrolyzed to free fatty acids (FFAs) before being absorbed and utilized further for lipid synthesis. Lipids can be hydrolyzed to FFAs in tissues by lipolytic enzymes, such as hormonesensitive lipase, lipoprotein lipase, and phospholipases A andC, before they
BIOMOLECULAR INTERACTION ANALYSIS With advanced Biacore instrument, various sensor chips and experienced technical staff, Creative Proteomics can provide cost-effective characterization service of biomolecular interactions. * For Research Use Only. Not for use in diagnostic procedures. Our customer service representatives are available 24 hours a day, 7 days a week. Inquiry. LABEL-BASED PROTEIN QUANTIFICATION TECHNOLOGY—ITRAQ, TMT TMT is a peptide in vitro labeling technology developed by Thermo Scientific in the United States. This technology can use up to 10 isotope labels to label the amino groups of polypeptides. After LC-MS / MS analysis, the relative content of proteins in 10 different samples can be compared at the same time.ISOELECTRIC POINT
The isoelectric point (pI) is the pH at which a particular molecule carries no net electrical charge. Because the specific mutations, truncation or post-translational modifications can change the pI of the natural proteins. The net charge on the molecule is affected both by its own pI, and pH of the surrounding environment, And the proteinscan
INTRODUCTION TO GAS CHROMATOGRAPHY—PRINCIPLES What is gas chromatography ?. Chromatography is a technique that separates components in a mixture by the difference in partitioning behavior between mobile and stationary phases. ELECTROSPRAY IONIZATION Electrospray Ionization. Electrospray ionization (ESI) is a technique to generate ions for mass spectrometry using electrospray by applying a high voltage to a liquid to produce an aerosol. Due to relatively fragile biomacromolecules, their structures are easily destroyed during the process of dissociation and ionization.PROTEIN ARRAY
Protein microarray is a powerful assay system that contains hundreds of molecules on one plate, including cytokines, phosphatases, receptors, and other proteins, which enables the characterization of hundreds of thousands of proteins in a highly parallel and high-throughput manner. GO ANNOTATION ANALYSIS SERVICE GO Annotation Analysis Service at Creative Proteomics could help your research with: Maintain and develop its controlled vocabulary of gene and gene product attributes. Assimilate and disseminate annotation data. Provide tools for easy access to all aspects of the data, enable functional interpretation of experimental data. PTM CROSSTALK ANALYSIS SERVICE The advent of highly sensitive MS-based strategies for large-scale PTM analysis substantially improved our knowledge about PTM and the co-occurrence/crosstalk of PTMs. As one of the leading omics industry company in the world, we are open to help you with TM Crosstalk Analysis Service. Protein function is largely destined bythree-dimensional
N-TERMINAL SEQUENCING ANALYSIS SERVICE The workflow of the N-terminal peptide sequencing via Edman degradation (Yun S.H et al. 2019).. 2) De novo N-terminal peptide sequencing by Tandem MS This technology is mainly through the use of fluorescent reagents to selectively label the N-terminal α-amino group of the protein, while using trypsin for protein digestion, with the help of LC-MS / MS system and Fluorescence detector performs UNTARGETED METABOLOMICS It also can provide you reliable metabolite identification. With integrated a set of separation, characterization, identification and quantification systems featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective Untargeted Metabolomics asbelow. Serum
MALDI-TOF-MS INTACT PROTEIN ANALYSIS MALDI-TOF-MS Intact Protein Analysis. The development and quality assessment of biopharmaceuticals, especially protein and peptide drugs, require a series of analytical techniques to assess the integrity of bioactive molecules during formulation andadministration.
OPLS-DA SERVICE
OPLS-DA Service. Orthogonal partial least squares discriminant analysis (OPLS-DA) was introduced as an improvement of the PLS-DA approach to discriminate two or more groups (classes) using multivariate data. In OPLS-DA, a regression model is constructed between the multivariate data and a response variable that only contains class information.ISOELECTRIC POINT
The isoelectric point (pI) is the pH at which a particular molecule carries no net electrical charge. Because the specific mutations, truncation or post-translational modifications can change the pI of the natural proteins. The net charge on the molecule is affected both by its own pI, and pH of the surrounding environment, And the proteinscan
ELECTROSPRAY IONIZATION Electrospray Ionization. Electrospray ionization (ESI) is a technique to generate ions for mass spectrometry using electrospray by applying a high voltage to a liquid to produce an aerosol. Due to relatively fragile biomacromolecules, their structures are easily destroyed during the process of dissociation and ionization. Q EXACTIVE HYBRID QUADRUPOLE-ORBITRAP MASS SPECTROMETER The Features of Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer. The resolution up to 140,000 to see more peaks in samples and it can improve results reliability when analyzing samples in complex matrices. Fast scan-to-scan polarity switching in PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Proteomics is a large-scale comprehensive study of a specific proteome, including information on protein abundances, the variations and modifications, as well as their interacting partners and networks. MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of A BRIEF INTRODUCTION TO PEPTIDE MAPPING The definition and principle of peptide mapping . The molecular weight and amino acid composition of the proteins and peptides, as well as the specific endonucleases to act on specific peptide chain, are used in Peptide mapping.Peptides are cut into small fragments byendonucleases.
FREE FATTY ACIDS (FFAS) ANALYSIS SERVICE In animals, many of the dietary lipids are hydrolyzed to free fatty acids (FFAs) before being absorbed and utilized further for lipidsynthesis.
LABEL-BASED PROTEIN QUANTIFICATION TECHNOLOGY—ITRAQ, TMT The dynamic changes of proteome abundance in cells have an important impact on various life processes. For example, the occurrence and development of many diseases is often accompanied by abnormal expression of certain proteins.ISOELECTRIC POINT
Introduction. Proteins are amphoteric molecules, which contain both acidic and basic amino acids. Amino acids that make up proteins may be positive, negative or neutral, depending on the environment pH, and thus give a protein its overall charge. BIOMOLECULAR INTERACTION ANALYSIS Surface Plasmon Resonance, SPR for short, is defined as the excitation of surface plasmon (collective charge oscillation along the interface between two materials) by incident light under the condition of total internal reflection. INTRODUCTION TO GAS CHROMATOGRAPHY—PRINCIPLES What is gas chromatography ?. Chromatography is a technique that separates components in a mixture by the difference in partitioning behavior between mobile and stationary phases. ELECTROSPRAY IONIZATION Electrospray ionization (ESI) is a technique to generate ions for mass spectrometry using electrospray by applying a high voltage to a liquid to produce an aerosol. PROTEOMICS SERVICES, INCLUDING PROTEIN IDENTIFICATIONSERVICESORDER ONLINEPEPTIDE CHARACTERIZATIONACADEMICENVIRONMENT Creative Proteomics offers a full range of services to support various proteome-related researches from identification of single proteins to large-scale proteomic studies.PROTEOMICS SERVICE
Proteomics is a large-scale comprehensive study of a specific proteome, including information on protein abundances, the variations and modifications, as well as their interacting partners and networks. MOLECULAR DYNAMICS SIMULATION SERVICE Molecular dynamics (MD) simulation is a computer simulation technique for studying the physical movements of atoms and molecules, and is a type of N-body simulation. The method was originally developed within the field of theoretical physics in the late 1950s. In this method, the atoms and molecules are allowed to interact for a given period of time, giving a view of the dynamical evolution of A BRIEF INTRODUCTION TO PEPTIDE MAPPING The definition and principle of peptide mapping . The molecular weight and amino acid composition of the proteins and peptides, as well as the specific endonucleases to act on specific peptide chain, are used in Peptide mapping.Peptides are cut into small fragments byendonucleases.
FREE FATTY ACIDS (FFAS) ANALYSIS SERVICE In animals, many of the dietary lipids are hydrolyzed to free fatty acids (FFAs) before being absorbed and utilized further for lipidsynthesis.
LABEL-BASED PROTEIN QUANTIFICATION TECHNOLOGY—ITRAQ, TMT The dynamic changes of proteome abundance in cells have an important impact on various life processes. For example, the occurrence and development of many diseases is often accompanied by abnormal expression of certain proteins.ISOELECTRIC POINT
Introduction. Proteins are amphoteric molecules, which contain both acidic and basic amino acids. Amino acids that make up proteins may be positive, negative or neutral, depending on the environment pH, and thus give a protein its overall charge. BIOMOLECULAR INTERACTION ANALYSIS Surface Plasmon Resonance, SPR for short, is defined as the excitation of surface plasmon (collective charge oscillation along the interface between two materials) by incident light under the condition of total internal reflection. INTRODUCTION TO GAS CHROMATOGRAPHY—PRINCIPLES What is gas chromatography ?. Chromatography is a technique that separates components in a mixture by the difference in partitioning behavior between mobile and stationary phases. ELECTROSPRAY IONIZATION Electrospray ionization (ESI) is a technique to generate ions for mass spectrometry using electrospray by applying a high voltage to a liquid to produce an aerosol.PROTEIN ARRAY
Protein microarray is a powerful assay system that contains hundreds of molecules on one plate, including cytokines, phosphatases, receptors, and other proteins, which enables the characterization of hundreds of thousands of proteins in a highly parallel and high-throughput manner. GO ANNOTATION ANALYSIS SERVICE Gene ontology, GO for short, is a quite powerful bioinformatics initiative to unify the representation of gene and gene product attributes across all species.Gene Ontology is established by Gene Ontology Consortium in 1998 in order to annotate and classify genes and their corresponding products. N-TERMINAL SEQUENCING ANALYSIS SERVICE The workflow of the N-terminal peptide sequencing via Edman degradation (Yun S.H et al. 2019).. 2) De novo N-terminal peptide sequencing by Tandem MS This technology is mainly through the use of fluorescent reagents to selectively label the N-terminal α-amino group of the protein, while using trypsin for protein digestion, with the help of LC-MS / MS system and Fluorescence detector performs PTM CROSSTALK ANALYSIS SERVICE Biological crosstalk refers to instances in which one or more components of one signal transduction pathway affects another. In the past few years, evidence for extensive crosstalk between PTMs has accumulated, with the competitive interplay between O-GlcNac and O-phosphorylation being one of the first and best-establishedexamples.
MALDI-TOF-MS INTACT PROTEIN ANALYSIS MALDI-TOF-MS Intact Protein Analysis. The development and quality assessment of biopharmaceuticals, especially protein and peptide drugs, require a series of analytical techniques to assess the integrity of bioactive molecules during formulation andadministration.
ISOELECTRIC POINT
Introduction. Proteins are amphoteric molecules, which contain both acidic and basic amino acids. Amino acids that make up proteins may be positive, negative or neutral, depending on the environment pH, and thus give a protein its overall charge.OPLS-DA SERVICE
Orthogonal partial least squares discriminant analysis (OPLS-DA) was introduced as an improvement of the PLS-DA approach to discriminate two or more groups (classes) using multivariate data. In OPLS-DA, a regression model is constructed between the multivariate data and a response variable that only contains class information. UNTARGETED METABOLOMICS Untargeted metabolomics, namely discovery metabolomics, involves the comparison of the metabolome between the control and test groups, to identify differences between their metabolite profiles which may be relevant to specific biological conditions. ELECTROSPRAY IONIZATION Electrospray ionization (ESI) is a technique to generate ions for mass spectrometry using electrospray by applying a high voltage to a liquid to produce an aerosol. Q EXACTIVE HYBRID QUADRUPOLE-ORBITRAP MASS SPECTROMETER The Thermo Scientific Q Exactive hybrid quadrupole-Orbitrap mass spectrometer is equipped with high-performance quadrupole with high-resolution, accurate-mass (HR/AM) Orbitrap detection.Navigation
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* Proteomics Service * Protein Gel and Imaging * Protein Identification * Protein Sample Preparation * Digestion (in-gel or in-solution) * Molecular Mass Determination * Protein Purity and Homogeneity Characterization * Sequence Analysis of Peptides or Proteins * Membrane Protein Identification * Accurate Mass Determination * Shotgun Protein Identification * Protein Quantification * iTRAQ-based Proteomics Aanalysis * TMT Based Proteomics Service * SILAC-based Proteomics Analysis * Absolute Quantification (AQUA) * Label-free Quantification * Semi-quantitative Proteomics Analysis * Parallel Reaction Monitoring (PRM)* SRM & MRM
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* Top Down Proteomics * Top Down-based Sequencing * Top Down-based Characterization of PTMs * Characterization of Protein Structure * Peptidomics Analysis * Characterization of Peptide Biomarkers * Comprehensive Peptidomics Service * Protein-Protein Interaction Networks * Co-immunoprecipitation (co-IP) * Crosslinking Protein Interaction Analysis * Far-Western Blot Analysis* Pull-Down Assay
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* N-Glycan Profiling * O-Glycan Profiling * N-Glycosylation Site Occupation * O-Glycosylation Site Occupation * N-Glycan Linkage Analysis * O-Glycan Linkage Analysis * Glycan Quantification * Structural Characterization of Glycans * Glycopeptides Analysis * Glycan-related Microarray Assay * Glyco-gene Microarray Assay * Lectin Microarray Assay * Glycan Microarray Assay * Microbial Glycan Microarray Assay * Glycopeptide Microarray Assay * Polysaccharide Analysis * Molecular Weight Determination of Polysaccharide * Determination of the Absolute Configuration * Identification of the Anomeric Configuration * Peptidoglycan Structure Analysis* Other Services
* Composition Analysis * Petroleum, Natural Gas, and Petrochemicals Analysis Service * Cosmetics Analysis Service * Flavors and Fragrances Analysis Service * Polymers Analysis Service * Specialty Chemicals Analysis Service * Pharmaceutics Analysis Service * Metallic Materials Analysis Service * Energy, Resources & Environment Analysis Service * Inorganic Non-metallic Materials Analysis Service * Flow Cytometry Service * Peptide Mass Fingerprinting (PMF) * De Novo Peptides/Proteins Sequencing* Peptide Mapping
* De Novo Antibody Sequencing * Amino Acid Analysis (AAA) * Host Cell Protein Analysis * Bioanalysis of DNA Methylations * Residual DNA Testing* Ames Test
* Identification of Bacterial Strains * Peptide Characterization * Peptide Purity Analysis * Structure Activity Relationship (SAR) Analysis* Cell-Based Assay
* Cell Migration Assay * Boyden Chamber Assay * Fluorescent-labeled Cell Migration Assay * Matrix Degradation Analysis Service * Cell Scratch Assay * Cell Exclusion Zone Assay* Cell Fence Assay
* Microfluidic Chamber Assay * Microcarrier Bead Assay * Three-Dimensional (3D) Spheroid Assay * Single Cell Migration Chip Assay * Leukocyte Migration Agarose Technique Assay * Single Cell Motility Assay * Cell Tracking Assay * Scanning Electrochemical Microscopy * Vascular Permeability Assay * Vascular Permeability Assay In Vivo * Vascular Permeability Assay with Microvessels * Tube Formation Assay * Cell Adhesion Assay * Cell-Cell Adhesion Assay * Cell-Cell Image Adhesion Assay * Cell Adhesion Microarray Assay * Cell Adhesion PCR Array Assay * Cell-Colored Adhesion Assay * Cell Invasion Assay * Transwell Invasion Assay * Gelatin Degradation Assay * Inverted Vertical Invasion Assay * Three-Dimensional Spheroid Invasion Assay * Spheroid Confrontation Assay * Cell Proliferation Assay * MTS Cell Proliferation Assay * MTT Cell Proliferation Assay * Fluorescent Cell Proliferation Assay * BrdU Cell Proliferation Assay * Cell Proliferation Assay with Immunoassay * Cell Proliferation Assay via DNA Synthesis * Bioinformatics Service * Bioinformatics for Proteomics * Functional Annotation and Enrichment Analysis Service * Clustering Analysis Service * Statistical Analysis Service * Network Analysis Service * Proteomic Analysis of Post-translational Modifications Service * Bioinformatics for Metabolomics * Bioinformatic Univariate Analysis Service * Multivariate Analysis Service * Clustering Analysis Service for Metabolomics * Bioinformatic Data Preprocess and Normalization Service * Bioinformatics for Protein * Protein Sequence Analysis Service * Protein Structure Analysis Service * Protein Evolution Analysis Service* Application
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PROFESSIONAL ANALYSIS TO MEET YOUR NEEDS World-leading contract research services for proteomics, metabolomics, glycomics, and bioinformatics.Read More
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EXPERT IN MASS SPECTROMETRY ANALYSIS State-of-the-art techniques, scalable informatics tools, and research expertise for various needs.Read More
OUR SERVICES
-------------------------PROTEOMICS SERVICE
A variety of proteomics services to assist your scientific research. METABOLOMICS SERVICE A wide range of metabolomics services from discovery to targetedanalysis.
GLYCOMICS SERVICE
Help to understand how glycans relate to a particular biologicalevent.
CELL-BASED ASSAY
Our cell-based assays are available for cell migration, adhesion, invasion, and proliferation. BIOINFORMATICS SERVICE To mine and interpret the tremendous data in high-throughput omicsstudies.
CUSTOMIZED SYNTHESIZED PEPTIDE/PROTEINS Various synthetic methods used and quality assurance files suppliedfor customers.
SUPPORT
------------------------- CHROMATOGRAPHY TECHNOLOGY Gas chromatography (GC), liquid chromatography (LC), high performance liquid chromatography (HPLC) and so on.Read More
SPECTROSCOPY TECHNOLOGY Nuclear magnetic resonance (NMR), Fourier transform-infrared spectroscopy (FT-IR) and so on.Read More
MASS SPECTROMETRY PLATFORM Mass spectrometry platform based on experienced experts and advancedinstruments.
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POPULAR SERVICES
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N-TERMINAL SEQUENCING Our professional protein sequencing platform provides N-terminal sequence analysis by Edman degradation or mass spectrometry (MS), with complementary advantages to each other.Read More
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_DE NOVO_ SEQUENCING _De novo_ sequencing is an appropriate method for identifying novel peptides, unsequenced organisms, and antibodies drugs, which can’t be detected by database search methods.Read More
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ITRAQ-BASED PROTEOMICS ANALYSIS iTRAQ, using isobaric reagents to label peptides, is ideally suited for comparing normal, diseased, and drug-treated samples, time course studies, biological replicates and provides relative quantitationinformation.
Read More
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SHORT CHAIN FATTY ACIDS ANALYSIS Short-chain fatty acids (SCFAs) are the end products of fermentation of the dietary fibers by large intestinal bacteria. We have established sensitive, reliable, and accurate GC-MS methods for quantification of short-chain fatty acidsRead More
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BILE ACIDS ANALYSIS
Bile acids, a large family of steroids, have a carboxyl group in the side chain. We have developed a sensitive and rapid method for the analysis of the 66 bile acids samples by LC-MS.Read More
*
N-TERMINAL SEQUENCING Our professional protein sequencing platform provides N-terminal sequence analysis by Edman degradation or mass spectrometry (MS), with complementary advantages to each other.Read More
*
_DE NOVO_ SEQUENCING _De novo_ sequencing is an appropriate method for identifying novel peptides, unsequenced organisms, and antibodies drugs, which can’t be detected by database search methods.Read More
*
ITRAQ-BASED PROTEOMICS ANALYSIS iTRAQ, using isobaric reagents to label peptides, is ideally suited for comparing normal, diseased, and drug-treated samples, time course studies, biological replicates and provides relative quantitationinformation.
Read More
*
SHORT CHAIN FATTY ACIDS ANALYSIS Short-chain fatty acids (SCFAs) are the end products of fermentation of the dietary fibers by large intestinal bacteria. We have established sensitive, reliable, and accurate GC-MS methods for quantification of short-chain fatty acidsRead More
*
BILE ACIDS ANALYSIS
Bile acids, a large family of steroids, have a carboxyl group in the side chain. We have developed a sensitive and rapid method for the analysis of the 66 bile acids samples by LC-MS.Read More
SERVICES
Proteomics Service
Metabolomics ServiceGlycomics Service
Cell-Based Assay
Bioinformatics ServiceSTAY IN CONTACT
* 45-1 Ramsey Road, Shirley, NY 11967, USA * TEL: 1-631-275-3058 * FAX: 1-631-614-7828 * EMAIL: info@creative-proteomics.com*
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