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participating.
EFFECTIVENESS OF IVERMECTIN IN SARS-COV-2/COVID-19 Ivermectin Prescribing protocol: Participants were prescribed Ivermectin 12mg stat per oral and then 12 mg per oral after 12 hours and 12mg per oral after 24 hours and we looked at the response at day 7 on follow up in terms of improvement of symptoms like (Fever, Cough, sore throat, Headache, Shortness of breath, lethargy, and fatigue. and any side effects of the drugs were noted as well. COMPARING THE ANTIBODY RESPONSE TO COVID-19 VACCINATION IN Comparing the Antibody Response to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab or Natalizumab - Full TextView.
ORAL SIDE EFFECTS OF COVID-19 VACCINE Dichotomous outcome for the emergence of oral side effects (e.g. ulcers, vesicles, blisters, plaque, mouth odour, bleeding gum, burning gingiva, etc) following receiving the COVID-19 vaccine. Secondary Outcome Measures : Dermatologic Side Effects [ Time ERN RECONNET STUDY ON COVID-19 VACCINATION IN RARE AND This is an observational study aimed at gathering sufficient number of cases of rCTDs patients who will receive COVID-19 vaccination that will help in better understanding of both safety and efficacy of the vaccine in this population. A STUDY TO TEST EFFICACY AND SAFETY OF ROZANOLIXIZUMAB IN The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. DECALCIFICATION OF THE AORTIC VALVE BY VITAMIN K2 The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. VULVAR CONTACT DERMATITIS RESULTING FROM URINE Vulvar contact dermatitis (VCD) is a common problem presenting as vulvar pruritus, burning or irritation. Its estimated prevalence is 20-30% in vulvar clinics, but the prevalence in the general population is unknown. Contact dermatitis is an inflammation of the skin resulting from an external agent that acts as an irritant or as anallergen.
HOME - CLINICALTRIALS.GOVFOR STUDY RECORD MANAGERSFIND TRIALSFIND STUDIESLOGINSUBMIT STUDIESABOUT STUDIES ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine. IMPORTANT: Listing a study does not mean it has been evaluated by the U.S. Federal Government.Read our disclaimer for details.. Before participating in a study, talk to your health care provider and learn about the risks and potential benefits. PFIZER-BIONTECH COVID-19 BNT162B2 VACCINE EFFECTIVENESS Pfizer-BioNTech COVID-19 BNT162b2 Vaccine Effectiveness Study - Kaiser Permanente Southern California - Full Text View. COVID-19 VACCINE AND OVARIAN RESERVE COVID-19 Vaccine and Ovarian Reserve. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider beforeparticipating.
EFFECTIVENESS OF IVERMECTIN IN SARS-COV-2/COVID-19 Ivermectin Prescribing protocol: Participants were prescribed Ivermectin 12mg stat per oral and then 12 mg per oral after 12 hours and 12mg per oral after 24 hours and we looked at the response at day 7 on follow up in terms of improvement of symptoms like (Fever, Cough, sore throat, Headache, Shortness of breath, lethargy, and fatigue. and any side effects of the drugs were noted as well. COMPARING THE ANTIBODY RESPONSE TO COVID-19 VACCINATION IN Comparing the Antibody Response to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab or Natalizumab - Full TextView.
ORAL SIDE EFFECTS OF COVID-19 VACCINE Dichotomous outcome for the emergence of oral side effects (e.g. ulcers, vesicles, blisters, plaque, mouth odour, bleeding gum, burning gingiva, etc) following receiving the COVID-19 vaccine. Secondary Outcome Measures : Dermatologic Side Effects [ Time ERN RECONNET STUDY ON COVID-19 VACCINATION IN RARE AND This is an observational study aimed at gathering sufficient number of cases of rCTDs patients who will receive COVID-19 vaccination that will help in better understanding of both safety and efficacy of the vaccine in this population. A STUDY TO TEST EFFICACY AND SAFETY OF ROZANOLIXIZUMAB IN The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. DECALCIFICATION OF THE AORTIC VALVE BY VITAMIN K2 The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. VULVAR CONTACT DERMATITIS RESULTING FROM URINE Vulvar contact dermatitis (VCD) is a common problem presenting as vulvar pruritus, burning or irritation. Its estimated prevalence is 20-30% in vulvar clinics, but the prevalence in the general population is unknown. Contact dermatitis is an inflammation of the skin resulting from an external agent that acts as an irritant or as anallergen.
SEARCH OF: COVID19
Note: The ClinicalTrials.gov search syntax is being updated to match the ClinicalTrials.gov application programming interface (API) search syntax.Documentation and interactive examples of the new syntax can be found on the ClinicalTrials.gov API web site.The current syntax will continue to work, but will not be updated to support new features. COVID-19 VACCINE AND OVARIAN RESERVE COVID-19 Vaccine and Ovarian Reserve. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider beforeparticipating.
SAFETY AND IMMUNOGENICITY OF EXG-5003 Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Prevention. Official Title: Safety and Immunogenicity of Intradermal SARS-CoV-2 Vaccine EXG-5003 in Healthy Adults. Actual Study Start Date : April 28, 2021. Estimated PrimaryCompletion Date :
ENHANCING TRANSDIAGNOSTIC MECHANISMS OF COGNITIVE The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to a high dose, low dose, or POLIO VACCINE (IPV) FOR SARS-COV-2 AND PREVENTION OF The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. EFFICACY OF NATURAL HONEY TREATMENT IN PATIENTS WITH NOVEL The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has been discovered recently in December 2019 from wuhan city in China to spread in more than 40 countries allover the world. PHASE 3 STUDY OF NIVOLUMAB OR NIVOLUMAB PLUS IPILIMUMAB Phase 3 Study of Nivolumab or Nivolumab Plus Ipilimumab Versus Ipilimumab Alone in Previously Untreated Advanced Melanoma (CheckMate 067) - Full Text View. PHASE 3 STUDY OF MRTX849 VS DOCETAXEL IN PATIENTS WITH Phase 3 Study of MRTX849 vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation - Full Text View. A STUDY OF ATEZOLIZUMAB (AN ENGINEERED ANTI-PROGRAMMED Dose-Escalation Cohorts: Predose (0 hr), 0.5 hr post-infusion (infusion duration=60 minutes ) on Day 1 of Cycles 1-5, 7 (Cycle length=21 days); Days 2, 4, 8, 15 of Cycle 1; predose (0 hr) on Day 1 of Cycles 8, 10, 12, 14, 16, 17, 20, every 8 cycles thereafter (up to approx 7 yrs), at treatment discontinuation & then every 30 days for up to 120 days after last dose of study treatment until CLINICALTRIALS.GOV PRS: LOGIN See Submit Studies on ClinicalTrials.gov for information on how to apply for a PRS account.. See PRS Guided Tutorials for assistance with entering registration and results information in the PRS.. Send email to ClinicalTrials.gov PRS Administration. HOME - CLINICALTRIALS.GOVFOR STUDY RECORD MANAGERSFIND TRIALSFIND STUDIESLOGINSUBMIT STUDIESABOUT STUDIES ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine. IMPORTANT: Listing a study does not mean it has been evaluated by the U.S. Federal Government.Read our disclaimer for details.. Before participating in a study, talk to your health care provider and learn about the risks and potential benefits. PFIZER-BIONTECH COVID-19 BNT162B2 VACCINE EFFECTIVENESS Pfizer-BioNTech COVID-19 BNT162b2 Vaccine Effectiveness Study - Kaiser Permanente Southern California - Full Text View. COVID-19 VACCINE AND OVARIAN RESERVE COVID-19 Vaccine and Ovarian Reserve. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider beforeparticipating.
EFFECTIVENESS OF IVERMECTIN IN SARS-COV-2/COVID-19 Ivermectin Prescribing protocol: Participants were prescribed Ivermectin 12mg stat per oral and then 12 mg per oral after 12 hours and 12mg per oral after 24 hours and we looked at the response at day 7 on follow up in terms of improvement of symptoms like (Fever, Cough, sore throat, Headache, Shortness of breath, lethargy, and fatigue. and any side effects of the drugs were noted as well. COMPARING THE ANTIBODY RESPONSE TO COVID-19 VACCINATION IN Comparing the Antibody Response to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab or Natalizumab - Full TextView.
ORAL SIDE EFFECTS OF COVID-19 VACCINE Dichotomous outcome for the emergence of oral side effects (e.g. ulcers, vesicles, blisters, plaque, mouth odour, bleeding gum, burning gingiva, etc) following receiving the COVID-19 vaccine. Secondary Outcome Measures : Dermatologic Side Effects [ Time ERN RECONNET STUDY ON COVID-19 VACCINATION IN RARE AND This is an observational study aimed at gathering sufficient number of cases of rCTDs patients who will receive COVID-19 vaccination that will help in better understanding of both safety and efficacy of the vaccine in this population. A STUDY TO TEST EFFICACY AND SAFETY OF ROZANOLIXIZUMAB IN The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. DECALCIFICATION OF THE AORTIC VALVE BY VITAMIN K2 The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. VULVAR CONTACT DERMATITIS RESULTING FROM URINE Vulvar contact dermatitis (VCD) is a common problem presenting as vulvar pruritus, burning or irritation. Its estimated prevalence is 20-30% in vulvar clinics, but the prevalence in the general population is unknown. Contact dermatitis is an inflammation of the skin resulting from an external agent that acts as an irritant or as anallergen.
HOME - CLINICALTRIALS.GOVFOR STUDY RECORD MANAGERSFIND TRIALSFIND STUDIESLOGINSUBMIT STUDIESABOUT STUDIES ClinicalTrials.gov is a resource provided by the U.S. National Library of Medicine. IMPORTANT: Listing a study does not mean it has been evaluated by the U.S. Federal Government.Read our disclaimer for details.. Before participating in a study, talk to your health care provider and learn about the risks and potential benefits. PFIZER-BIONTECH COVID-19 BNT162B2 VACCINE EFFECTIVENESS Pfizer-BioNTech COVID-19 BNT162b2 Vaccine Effectiveness Study - Kaiser Permanente Southern California - Full Text View. COVID-19 VACCINE AND OVARIAN RESERVE COVID-19 Vaccine and Ovarian Reserve. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider beforeparticipating.
EFFECTIVENESS OF IVERMECTIN IN SARS-COV-2/COVID-19 Ivermectin Prescribing protocol: Participants were prescribed Ivermectin 12mg stat per oral and then 12 mg per oral after 12 hours and 12mg per oral after 24 hours and we looked at the response at day 7 on follow up in terms of improvement of symptoms like (Fever, Cough, sore throat, Headache, Shortness of breath, lethargy, and fatigue. and any side effects of the drugs were noted as well. COMPARING THE ANTIBODY RESPONSE TO COVID-19 VACCINATION IN Comparing the Antibody Response to COVID-19 Vaccination in Multiple Sclerosis Patients Treated With Ocrelizumab or Natalizumab - Full TextView.
ORAL SIDE EFFECTS OF COVID-19 VACCINE Dichotomous outcome for the emergence of oral side effects (e.g. ulcers, vesicles, blisters, plaque, mouth odour, bleeding gum, burning gingiva, etc) following receiving the COVID-19 vaccine. Secondary Outcome Measures : Dermatologic Side Effects [ Time ERN RECONNET STUDY ON COVID-19 VACCINATION IN RARE AND This is an observational study aimed at gathering sufficient number of cases of rCTDs patients who will receive COVID-19 vaccination that will help in better understanding of both safety and efficacy of the vaccine in this population. A STUDY TO TEST EFFICACY AND SAFETY OF ROZANOLIXIZUMAB IN The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. DECALCIFICATION OF THE AORTIC VALVE BY VITAMIN K2 The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. VULVAR CONTACT DERMATITIS RESULTING FROM URINE Vulvar contact dermatitis (VCD) is a common problem presenting as vulvar pruritus, burning or irritation. Its estimated prevalence is 20-30% in vulvar clinics, but the prevalence in the general population is unknown. Contact dermatitis is an inflammation of the skin resulting from an external agent that acts as an irritant or as anallergen.
SEARCH OF: COVID19
Note: The ClinicalTrials.gov search syntax is being updated to match the ClinicalTrials.gov application programming interface (API) search syntax.Documentation and interactive examples of the new syntax can be found on the ClinicalTrials.gov API web site.The current syntax will continue to work, but will not be updated to support new features. COVID-19 VACCINE AND OVARIAN RESERVE COVID-19 Vaccine and Ovarian Reserve. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider beforeparticipating.
SAFETY AND IMMUNOGENICITY OF EXG-5003 Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Prevention. Official Title: Safety and Immunogenicity of Intradermal SARS-CoV-2 Vaccine EXG-5003 in Healthy Adults. Actual Study Start Date : April 28, 2021. Estimated PrimaryCompletion Date :
ENHANCING TRANSDIAGNOSTIC MECHANISMS OF COGNITIVE The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to a high dose, low dose, or POLIO VACCINE (IPV) FOR SARS-COV-2 AND PREVENTION OF The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. EFFICACY OF NATURAL HONEY TREATMENT IN PATIENTS WITH NOVEL The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) has been discovered recently in December 2019 from wuhan city in China to spread in more than 40 countries allover the world. PHASE 3 STUDY OF NIVOLUMAB OR NIVOLUMAB PLUS IPILIMUMAB Phase 3 Study of Nivolumab or Nivolumab Plus Ipilimumab Versus Ipilimumab Alone in Previously Untreated Advanced Melanoma (CheckMate 067) - Full Text View. PHASE 3 STUDY OF MRTX849 VS DOCETAXEL IN PATIENTS WITH Phase 3 Study of MRTX849 vs Docetaxel in Patients With Advanced Non-Small Cell Lung Cancer With KRAS G12C Mutation - Full Text View. A STUDY OF ATEZOLIZUMAB (AN ENGINEERED ANTI-PROGRAMMED Dose-Escalation Cohorts: Predose (0 hr), 0.5 hr post-infusion (infusion duration=60 minutes ) on Day 1 of Cycles 1-5, 7 (Cycle length=21 days); Days 2, 4, 8, 15 of Cycle 1; predose (0 hr) on Day 1 of Cycles 8, 10, 12, 14, 16, 17, 20, every 8 cycles thereafter (up to approx 7 yrs), at treatment discontinuation & then every 30 days for up to 120 days after last dose of study treatment until CLINICALTRIALS.GOV PRS: LOGIN See Submit Studies on ClinicalTrials.gov for information on how to apply for a PRS account.. See PRS Guided Tutorials for assistance with entering registration and results information in the PRS.. Send email to ClinicalTrials.gov PRS Administration.Hide glossary __
GLOSSARY
Study record managers: refer to the Data Element Definitionsif
submitting registration or results information.Search for terms
x
* Accepts healthy volunteers A type of eligibility criteria that indicates whether people who do not have the condition/disease being studied can participate in thatclinical study.
* Active comparator arm An arm type in which a group of participants receives an intervention/treatment considered to be effective (or active) by health care providers.* Adverse event
An unfavorable change in the health of a participant, including abnormal laboratory findings, that happens during a clinical study or within a certain amount of time after the study has ended. This change may or may not be caused by the intervention/treatment being studied.* Age or age group
A type of eligibility criteria that indicates the age a person must be to participate in a clinical study. This may be indicated by a specific age or the following age groups:The age groups are:
* Child (birth-17)
* Adult (18-64)
* Older Adult (65+)
* All-cause mortality A measure of all deaths, due to any cause, that occur during aclinical study.
* Allocation
A method used to assign participants to an arm of a clinical study. The types of allocation are randomized allocation and nonrandomized.* Arm
A group or subgroup of participants in a clinical trial that receives a specific intervention/treatment, or no intervention, according to the trial's protocol.* Arm type
A general description of the clinical trial arm. It identifies the role of the intervention that participants receive. Types of arms include experimental arm, active comparator arm, placebo comparator arm, sham comparator arm, and no intervention arm. * Baseline characteristics Data collected at the beginning of a clinical study for all participants and for each arm or comparison group. These data include demographics, such as age, sex/gender, race and ethnicity, and study-specific measures (for example, systolic blood pressure, prior antidepressant treatment). * Canceled submission Indicates that the study sponsor or investigator recalled a submission of study results before quality control (QC) review took place. If the submission was canceled on or after May 8, 2018, the date is shown. After submission of study results, a study record cannot be modified until QC review is completed, unless the submission is canceled. * Certain agreements Information required by the Food and Drug Administration Amendments Act of 2007. In general, this is a description of any agreement between the sponsor of a clinical study and the principal investigator (PI) that does not allow the PI to discuss the results of the study or publish the study results in a scientific or academic journal after the study is completed.* Certification
A sponsor or investigator may submit a certification to delay submission of results information if they are applying for FDA approval of a new drug or device, or new use of an already approved drug or device. A sponsor or investigator who submits a certification can delay results submission up to 2 years after the certification/extension first submitted date, unless certain events occur sooner. See Delay Results Type in the Results Data Element definitions for more information aboutthis certification.
* Certification/extension first posted The date on which information about a certification to delay submission of results or an extension request was first available on ClinicalTrials.gov. ClinicalTrials.gov does not indicate whether the submission was a certification or extension request. There is typically a delay between the date the study sponsor or investigator submitted the certification or extension request and the first posteddate.
* Certification/extension first submitted The date on which the study sponsor or investigator first submitted a certification or an extension request to delay submission of results. A sponsor or investigator who submits a certification can delay results submission up to 2 years after this date, unless certain events occur sooner. There is typically a delay between the date the certification or extension request was submitted and the date the information is first available on ClinicalTrials.gov (certification/extension first posted). * Certification/extension first submitted that met QC criteria The date on which the study sponsor or investigator first submitted a certification or an extension request that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a certification or extension request one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria. Meeting QC criteria for an extension request does not mean that the National Institutes of Health (NIH) has determined that the request demonstrates good cause. The process for review and granting of extension requests by the NIH is being developed.* City and distance
In the search feature, the City field is used to find clinical studies with locations in a specific city. The Distance field is used to find studies with locations within the specified distance from a city in number of miles. For example, if you choose Illinois as the state, identifying "Chicago" as the city and "100 miles" as the distance will find all studies listing a location within 100 miles of Chicago.* Clinical study
A research study involving human volunteers (also called participants) that is intended to add to medical knowledge. There are two types of clinical studies: interventional studies (also called clinical trials) and observational studies.* Clinical trial
Another name for an interventional study. * ClinicalTrials.gov identifier (NCT number) The unique identification code given to each clinical study upon registration at ClinicalTrials.gov. The format is "NCT" followed by an 8-digit number (for example, NCT00000419).* Collaborator
An organization other than the sponsor that provides support for a clinical study. This support may include activities related to funding, design, implementation, data analysis, or reporting.* Condition/disease
The disease, disorder, syndrome, illness, or injury that is being studied. On ClinicalTrials.gov, conditions may also include other health-related issues, such as lifespan, quality of life, and healthrisks.
* Contact
The name and contact information for the person who can answer enrollment questions for a clinical study. Each location where the study is being conducted may also have a specific contact, who may be better able to answer those questions.* Country
In the search feature, the Country field is used to find clinical studies with locations in a specific country. For example, if you choose the United States, you can then narrow your search by selecting a state and identifying a city and distance. * Cross-over assignment A type of intervention model describing a clinical trial in which groups of participants receive two or more interventions in a specific order. For example, two-by-two cross-over assignment involves two groups of participants. One group receives drug A during the initial phase of the trial, followed by drug B during a later phase. The other group receives drug B during the initial phase, followed by drug A. So during the trial, participants "cross over" to the other drug. All participants receive drug A and drug B at some point during the trial but in a different order, depending on the group to which they areassigned.
* Data Monitoring Committee (DMC) A group of independent scientists who monitor the safety and scientific integrity of a clinical trial. The DMC can recommend to the sponsor that the trial be stopped if it is not effective, is harming participants, or is unlikely to serve its scientific purpose. Members are chosen based on the scientific skills and knowledge needed to monitor the particular trial. Also called a data safety and monitoringboard, or DSMB.
* Early Phase 1 (formerly listed as Phase 0) A phase of research used to describe exploratory trials conducted before traditional phase 1 trials to investigate how or whether a drug affects the body. They involve very limited human exposure to the drug and have no therapeutic or diagnostic goals (for example, screening studies, microdose studies). * Eligibility criteria The key requirements that people who want to participate in a clinical study must meet or the characteristics they must have. Eligibility criteria consist of both inclusion criteria (which are required for a person to participate in the study) and exclusion criteria (which prevent a person from participating). Types of eligibility criteria include whether a study accepts healthy volunteers, has age or age group requirements, or is limited by sex.* Enrollment
The number of participants in a clinical study. The "estimated" enrollment is the target number of participants that the researchersneed for the study.
* Exclusion criteria A type of eligibility criteria. These are reasons that a person is not allowed to participate in a clinical study.* Expanded access
A way for patients with serious diseases or conditions who cannot participate in a clinical trial to gain access to a medical product that has not been approved by the U.S. Food and Drug Administration (FDA). Also called compassionate use. There are different expandedaccess types.
For more information, see FDA Expanded Access: Information forPatients
.
* Expanded access status * AVAILABLE: Expanded access is currently available for this investigational treatment, and patients who are not participants in the clinical study may be able to gain access to the drug, biologic, or medical device being studied. * NO LONGER AVAILABLE: Expanded access was available for this intervention previously but is not currently available and will not be available in the future. * TEMPORARILY NOT AVAILABLE: Expanded access is not currently available for this intervention but is expected to be available in thefuture.
* APPROVED FOR MARKETING: The intervention has been approved by the U.S. Food and Drug Administration for use by the public. * Expanded access type Describes the category of expanded access under U.S. Food and Drug Administration (FDA) regulations. There are three types of expandedaccess:
* INDIVIDUAL PATIENTS: Allows a single patient, with a serious disease or condition who cannot participate in a clinical trial, access to a drug or biological product that has not been approved by the FDA. This category also includes access in an emergency situation. * INTERMEDIATE-SIZE POPULATION: Allows more than one patient (but generally fewer patients than through a Treatment IND/Protocol) access to a drug or biological product that has not been approved by the FDA. This type of expanded access is used when multiple patients with the same disease or condition seek access to a specific drug or biological product that has not been approved by the FDA. * TREATMENT IND/PROTOCOL: Allows a large, widespread population access to a drug or biological product that has not been approved by the FDA. This type of expanded access can only be provided if the product is already being developed for marketing for the same use as the expanded access use.* Experimental arm
An arm type in which a group of participants receives the intervention/treatment that is the focus of the clinical trial.* Extension request
In certain circumstances, a sponsor or investigator may request an extension to delay the standard results submission deadline (generally one year after the primary completion date). The request for an extension must demonstrate good cause (for example, the need to preserve the scientific integrity of an ongoing masked trial). All requests must be reviewed and granted by the National Institutes of Health. This process for review and granting of extension requests is being developed. See Delay Results Type in the Results Data Element definitions for more information. * Factorial assignment A type of intervention model describing a clinical trial in which groups of participants receive one of several combinations of interventions. For example, two-by-two factorial assignment involves four groups of participants. Each group receives one of the following pairs of interventions: (1) drug A and drug B, (2) drug A and a placebo, (3) a placebo and drug B, or (4) a placebo and a placebo. So during the trial, all possible combinations of the two drugs (A and B) and the placebos are given to different groups of participants.* First posted
The date on which the study record was first available on ClinicalTrials.gov. There is typically a delay of a few days between the date the study sponsor or investigator submitted the study record and the first posted date.* First submitted
The date on which the study sponsor or investigator first submitted a study record to ClinicalTrials.gov. There is typically a delay of a few days between the first submitted date and the record's availability on ClinicalTrials.gov (the first posted date). * First submitted that met QC criteria The date on which the study sponsor or investigator first submits a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit a study record one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria. * Food and Drug Administration Amendments Act of 2007, Section 801(FDAAA 801)
U.S. Public Law 110-85, which was enacted on September 27, 2007. Section 801 of FDAAA amends Section 402 of the U.S. Public Health Service Act to expand ClinicalTrials.gov and create a clinical study results database. For more information on FDAAA 801, see the History,Policies, and Laws
page on this site.
* Funder type
Describes the organization that provides funding or support for a clinical study. This support may include activities related to funding, design, implementation, data analysis, or reporting. Organizations listed as sponsors and collaborators for a study are considered the funders of the study. ClinicalTrials.gov refers to fourtypes of funders:
* U.S. National Institutes of Health * Other U.S. Federal agencies (for example, Food and Drug Administration, Centers for Disease Control and Prevention, or U.S. Department of Veterans Affairs) * Industry (for example: pharmaceutical and device companies) * All others (including individuals, universities, and community-based organizations) * Gender-based eligibility A type of eligibility criteria that indicates whether eligibility to participate in a clinical study is based a person's self-representation of gender identity or gender (yes, no). Gender isdistinct from sex.
* Group/cohort
A group or subgroup of participants in an observational study that is assessed for biomedical or health outcomes. * Human subjects protection review board A group of people who review, approve, and monitor the clinical study's protocol. Their role is to protect the rights and welfare of people participating in a study (referred to as human research subjects), such as reviewing the informed consent form. The group typically includes people with varying backgrounds, including a community member, to make sure that research activities conducted by an organization are completely and adequately reviewed. Also called an institutional review board, or IRB, or an ethics committee. For more information, see Participating in Studieson
this site.
* Inclusion criteria A type of eligibility criteria. These are the reasons that a person is allowed to participate in a clinical study.* Informed consent
A process used by researchers to communicate to potential and enrolled participants the risks and potential benefits of participating in aclinical study.
For more information, see Participating in Studieson
this site.
* Informed consent form (ICF) The document used in the informed consent or process. * Intervention model The general design of the strategy for assigning interventions to participants in a clinical study. Types of intervention models include: single group assignment, parallel assignment, cross-over assignment, and factorial assignment. * Intervention/treatment A process or action that is the focus of a clinical study. Interventions include drugs, medical devices, procedures, vaccines, and other products that are either investigational or already available. Interventions can also include noninvasive approaches, such as education or modifying diet and exercise. * Interventional study (clinical trial) A type of clinical study in which participants are assigned to groups that receive one or more intervention/treatment (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. The assignments are determined by the study's protocol. Participants may receive diagnostic, therapeutic, or other types of interventions.* Investigator
A researcher involved in a clinical study. Related terms include site principal investigator, site sub-investigator, study chair, study director, and study principal investigator. * Last update posted The most recent date on which changes to a study record were made available on ClinicalTrials.gov. There may be a delay between when the changes were submitted to ClinicalTrials.gov by the study's sponsor or investigator (the last update submitted date) and the last updateposted date.
* Last update submitted The most recent date on which the study sponsor or investigator submitted changes to a study record to ClinicalTrials.gov. There is typically a delay of a few days between the last update submitted date and when the date changes are posted on ClinicalTrials.gov (the last update posted date). * Last update submitted that met QC criteria The most recent date on which the study sponsor or investigator submitted changes to a study record that are consistent with National Library of Medicine (NLM) quality control (QC) review criteria. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC review criteria.* Last verified
The most recent date on which the study sponsor or investigator confirmed the information about a clinical study on ClinicalTrials.gov as accurate and current. If a study with a recruitment status of recruiting; not yet recruiting; or active, not recruiting has not been confirmed within the past 2 years, the study's recruitment status isshown as unknown.
* Listed location countries Countries in which research facilities for a study are located. A country is listed only once, even if there is more than one facility in the country. The list includes all countries as of the last update submitted date; any country for which all facilities were removed from the study record are listed under removed location countries.* Location terms
In the search feature, the Location terms field is used to narrow a search by location-related terms other than Country, State, and City or distance. For example, you may enter a specific facility name (such as National Institutes of Health Clinical Center) or a part of a facility name (such as Veteran for studies listing Veterans Hospital or Veteran Affairs in the facility name). Note: Not all study records include this level of detail about locations.* Masking
A clinical trial design strategy in which one or more parties involved in the trial, such as the investigator or participants, do not know which participants have been assigned which interventions. Types of masking include: open label, single blind masking, and double-blindmasking.
* NCT number
A unique identification code given to each clinical study record registered on ClinicalTrials.gov. The format is "NCT" followed by an 8-digit number (for example, NCT00000419). Also called the ClinicalTrials.gov identifier. * No intervention arm An arm type in which a group of participants does not receive any intervention/treatment during the clinical trial. * Observational study A type of clinical study in which participants are identified as belonging to study groups and are assessed for biomedical or health outcomes. Participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to a specific interventions/treatment. A patient registry is a type of observational study. * Observational study model The general design of the strategy for identifying and following up with participants during an observational study. Types of observational study models include cohort, case-control, case-only, case-cross-over, ecologic or community studies, family-based, andother.
* Other adverse event An adverse event that is not a serious adverse event, meaning that it does not result in death, is not life-threatening, does not require inpatient hospitalization or extend a current hospital stay, does not result in an ongoing or significant incapacity or interfere substantially with normal life functions, and does not cause a congenital anomaly or birth defect; it also does not put the participant in danger and does not require medical or surgical intervention to prevent one of the results listed above.* Other study IDs
Identifiers or ID numbers other than the NCT number that are assigned to a clinical study by the study's sponsor, funders, or others. These numbers may include unique identifiers from other trial registries and National Institutes of Health grant numbers.* Other terms
In the search feature, the Other terms field is used to narrow a search. For example, you may enter the name of a drug or the NCT number of a clinical study to limit the search to study records that contain these words.* Outcome measure
For clinical trials, a planned measurement described in the protocol that is used to determine the effect of an intervention/treatment on participants. For observational studies, a measurement or observation that is used to describe patterns of diseases or traits, or associations with exposures, risk factors, or treatment. Types of outcome measures include primary outcome measure and secondary outcomemeasure.
* Parallel assignment A type of intervention model describing a clinical trial in which two or more groups of participants receive different interventions. For example, a two-arm parallel assignment involves two groups of participants. One group receives drug A, and the other group receives drug B. So during the trial, participants in one group receive drug A "in parallel" to participants in the other group, who receive drug B.* Participant flow
A summary of the progress of participants through each stage of a clinical study, by study arm or group/cohort. This includes the number of participants who started, completed, and dropped out of the study.* Patient registry
A type of observational study that collects information about patients' medical conditions and/or treatments to better understand how a condition or treatment affects patients in the real world.* Phase
The stage of a clinical trial studying a drug or biological product, based on definitions developed by the U.S. Food and Drug Administration (FDA). The phase is based on the study's objective, the number of participants, and other characteristics. There are five phases: Early Phase 1 (formerly listed as Phase 0), Phase 1, Phase 2, Phase 3, and Phase 4. Not Applicable is used to describe trials without FDA-defined phases, including trials of devices or behavioralinterventions.
* Phase 1
A phase of research to describe clinical trials that focus on the safety of a drug. They are usually conducted with healthy volunteers, and the goal is to determine the drug's most frequent and serious adverse events and, often, how the drug is broken down and excreted by the body. These trials usually involve a small number of participants.* Phase 2
A phase of research to describe clinical trials that gather preliminary data on whether a drug works in people who have a certain condition/disease (that is, the drug's effectiveness). For example, participants receiving the drug may be compared to similar participants receiving a different treatment, usually an inactive substance (called a placebo) or a different drug. Safety continues to be evaluated, and short-term adverse events are studied.* Phase 3
A phase of research to describe clinical trials that gather more information about a drug's safety and effectiveness by studying different populations and different dosages and by using the drug in combination with other drugs. These studies typically involve moreparticipants.
* Phase 4
A phase of research to describe clinical trials occurring after FDA has approved a drug for marketing. They include postmarket requirement and commitment studies that are required of or agreed to by the study sponsor. These trials gather additional information about a drug's safety, efficacy, or optimal use. * Phase Not Applicable Describes trials without FDA-defined phases, including trials of devices or behavioral interventions.* Placebo
An inactive substance or treatment that looks the same as, and is given in the same way as, an active drug or intervention/treatmentbeing studied.
* Placebo comparator arm An arm type in which a group of participants receives a placebo duringa clinical trial.
* Primary completion date The date on which the last participant in a clinical study was examined or received an intervention to collect final data for the primary outcome measure. Whether the clinical study ended according to the protocol or was terminated does not affect this date. For clinical studies with more than one primary outcome measure with different completion dates, this term refers to the date on which data collection is completed for all the primary outcome measures. The "estimated" primary completion date is the date that the researchers think will be the primary completion date for the study. * Primary outcome measure In a clinical study's protocol, the planned outcome measure that is the most important for evaluating the effect of an intervention/treatment. Most clinical studies have one primary outcome measure, but some have more than one.* Primary purpose
The main reason for the clinical trial. The types of primary purpose are: treatment, prevention, diagnostic, supportive care, screening, health services research, basic science, and other. * Principal investigator (PI) The person who is responsible for the scientific and technical direction of the entire clinical study.* Protocol
The written description of a clinical study. It includes the study's objectives, design, and methods. It may also include relevant scientific background and statistical information. * Quality control (QC) review National Library of Medicine (NLM) staff perform a limited review of submitted study records for apparent errors, deficiencies, or inconsistencies. NLM staff identify potential major and advisory issues and provide comments directly to the study sponsor or investigator. Major issues identified in QC review must be addressed or corrected (see First submitted that met QC criteria and Results first submitted that met QC criteria). Advisory issues are suggestions to help improve the clarity of the record. NLM staff do not verify the scientific validity or relevance of the submitted information. The study sponsor or investigator is responsible for ensuring that the studies follow all applicable laws and regulations. * Randomized allocation A type of allocation strategy in which participants are assigned to the arms of a clinical trial by chance. * Recruitment status * NOT YET RECRUITING: The study has not started recruitingparticipants.
* RECRUITING: The study is currently recruiting participants. * ENROLLING BY INVITATION: The study is selecting its participants from a population, or group of people, decided on by the researchers in advance. These studies are not open to everyone who meets the eligibility criteria but only to people in that particular population, who are specifically invited to participate. * ACTIVE, NOT RECRUITING: The study is ongoing, and participants are receiving an intervention or being examined, but potential participants are not currently being recruited or enrolled. * SUSPENDED: The study has stopped early but may start again. * TERMINATED: The study has stopped early and will not start again. Participants are no longer being examined or treated. * COMPLETED: The study has ended normally, and participants are no longer being examined or treated (that is, the last participant's last visit has occurred). * WITHDRAWN: The study stopped early, before enrolling its firstparticipant.
* UNKNOWN: A study on ClinicalTrials.gov whose last known status was recruiting; not yet recruiting; or active, not recruiting but that has passed its completion date, and the status has not been last verified within the past 2 years.* Registration
The process of submitting and updating summary information about a clinical study and its protocol, from its beginning to end, to a structured, public Web-based study registry that is accessible to the public, such as ClinicalTrials.gov. * Removed location countries Countries that appeared under listed location countries but were removed from the study record by the sponsor or investigator.* Reporting group
A grouping of participants in a clinical study that is used for summarizing the data collected during the study. This grouping may be the same as or different from a study arm or group.* Responsible party
The person responsible for submitting information about a clinical study to ClinicalTrials.gov and updating that information. Usually the study sponsor or investigator.* Results database
A structured online system, such as the ClinicalTrials.gov results database, that provides the public with access to registration and summary results information for completed or terminated clinical studies. A study with results available on ClinicalTrials.gov is described as having the results "posted." NOTE: The ClinicalTrials.gov results database became available in September 2008. Older studies are unlikely to have results availablein the database.
* Results delayed
Indicates that the sponsor or investigator submitted a certification or extension request. * Results first posted The date on which summary results information was first available on ClinicalTrials.gov. There is typically a delay between the date the study sponsor or investigator first submits summary results information (the results first submitted date) and the results firstposted date.
* Results first submitted The date on which the study sponsor or investigator first submits a study record with summary results information. There is typically a delay between the results first submitted date and when summary results information becomes available on ClinicalTrials.gov (the results first posted date). * Results first submitted that met QC criteria The date on which the study sponsor or investigator first submits a study record with summary results information that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria. The sponsor or investigator may need to revise and submit results information one or more times before NLM's QC review criteria are met. It is the responsibility of the sponsor or investigator to ensure that the study record is consistent with the NLM QC reviewcriteria.
* Results returned after quality control review The date on which the National Library of Medicine provided quality control (QC) review comments to the study sponsor or investigator. The sponsor or investigator must address major issues identified in the review comments. If there is a date listed for results returned after quality control review, but there is not a subsequent date listed for results submitted to ClinicalTrials.gov, this means that the submission is pending changes by the sponsor or investigator. * Results submitted to ClinicalTrials.gov Indicates that the study sponsor or investigator has submitted summary results information for a clinical study to ClinicalTrials.gov but the quality control (QC) review process has not concluded. The results submitted date indicates when the study sponsor or investigator first submitted summary results information or submitted changes to summary results information. Submissions with changes are typically in response to QC review comments from the National Library of Medicine (NLM). If there is a date listed for results submitted to ClinicalTrials.gov, but there is not a subsequent date listed for results returned after quality control review, this means that the submission is pending review by NLM. * Secondary outcome measure In a clinical study's protocol, a planned outcome measure that is not as important as the primary outcome measure for evaluating the effect of an intervention but is still of interest. Most clinical studies have more than one secondary outcome measure. * Serious adverse event An adverse event that results in death, is life-threatening, requires inpatient hospitalization or extends a current hospital stay, results in an ongoing or significant incapacity or interferes substantially with normal life functions, or causes a congenital anomaly or birth defect. Medical events that do not result in death, are not life-threatening, or do not require hospitalization may be considered serious adverse events if they put the participant in danger or require medical or surgical intervention to prevent one of the resultslisted above.
* Sex
A type of eligibility criteria that indicates the sex of people who may participate in a clinical study (all, female, male). Sex is a person's classification as female or male based on biological distinctions. Sex is distinct from gender-based eligibility. * Sham comparator arm An arm type in which a group of participants receives a procedure or device that appears to be the same as the actual procedure or device being studied but does not contain active processes or components. * Single group assignment A type of intervention model describing a clinical trial in which all participants receive the same intervention/treatment.* Sort studies by
In Advanced Search, the Sort studies by option is used to change the order of studies listed on the Search Results page. You can sort by Relevance or Newest First: * Relevance: Studies that best match your search terms appear higher in the search results list. This is the default display for allsearches.
* Newest First: Studies with the most recent First posted dates appear higher in the search results list.* Sponsor
The organization or person who initiates the study and who has authority and control over the study.* State
In the search feature, the State field is used to find clinical studies with locations in a specific state within the United States. If you choose United States in the Country field, you can search for studies with locations in a specific state. * Statistical analysis plan (SAP) The written description of the statistical considerations and methods for analyzing the data collected in the clinical study.* Status
Indicates the current recruitment status or the expanded accessstatus.
* Study completion date The date on which the last participant in a clinical study was examined or received an intervention/treatment to collect final data for the primary outcome measures, secondary outcome measures, and adverse events (that is, the last participant's last visit). The "estimated" study completion date is the date that the researchers think will be the study completion date.* Study design
The investigative methods and strategies used in the clinical study.* Study documents
Refers to the type of documents that the study sponsor or principal investigator may add to their study record. These include a study protocol, statistical analysis plan, and informed consent form.* Study IDs
Identifiers that are assigned to a clinical study by the study's sponsor, funders, or others. They include unique identifiers from other trial study registries and National Institutes of Health grant numbers. Note: ClinicalTrials.gov assigns a unique identification code to each clinical study registered on ClinicalTrials.gov. Also called the NCT number, the format is "NCT" followed by an 8-digit number (for example, NCT00000419).* Study record
An entry on ClinicalTrials.gov that contains a summary of a clinical study's protocol information, including the recruitment status; eligibility criteria; contact information; and, in some cases, summary results. Each study record is assigned a ClinicalTrials.gov identifier, or NCT number.* Study registry
A structured online system, such as ClinicalTrials.gov, that provides the public with access to summary information about ongoing and completed clinical studies.* Study results
A study record that includes the summary results posted in the ClinicalTrials.gov results database. Summary results information includes participant flow, baseline characteristics, outcome measures, and adverse events (including serious adverse events).* Study start date
The actual date on which the first participant was enrolled in a clinical study. The "estimated" study start date is the date that the researchers think will be the study start date.* Study type
Describes the nature of a clinical study. Study types include interventional studies (also called clinical trials), observational studies (including patient registries), and expanded access.* Submitted date
The date on which the study sponsor or investigator submitted a study record that is consistent with National Library of Medicine (NLM) quality control (QC) review criteria.* Title
The official title of a protocol used to identify a clinical study or a short title written in language intended for the lay public.* Title acronym
The acronym or initials used to identify a clinical study (not all studies have one). For example, the title acronym for the Women's Health Initiative is "WHI." * U.S. Agency for Healthcare Research and Quality (AHRQ) An agency within the U.S. Department of Health and Human Services. AHRQ's mission is to produce evidence to make health care safer, higher quality, more accessible, equitable, and affordable, and to work within the U.S. Department of Health and Human Services and with other partners to make sure that the evidence is understood and used. * U.S. Food and Drug Administration (FDA) An agency within the U.S. Department of Health and Human Services. The FDA is responsible for protecting the public health by making sure that human and veterinary drugs, vaccines and other biological products, medical devices, the Nation's food supply, cosmetics, dietary supplements, and products that give off radiation are safe, effective, and secure.* Unknown
A type of recruitment status. It identifies a study on ClinicalTrials.gov whose last known status was recruiting; not yet recruiting; or active, not recruiting but that has passed its completion date, and the status has not been verified within the past 2 years. Studies with an unknown status are considered closed studies. Skip to Main Content Help guide our efforts to modernize ClinicalTrials.gov.
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* How to Use Search Results * How to Find Results of Studies * How to Read a Study Record* About Studies
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CLINICALTRIALS.GOV IS A DATABASE OF PRIVATELY AND PUBLICLY FUNDED CLINICAL STUDIES CONDUCTED AROUND THE WORLD. ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conductedaround the world.
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