Biomolecular NMR Lab at IISERB
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BIOMOLECULAR NMR LAB AT IISERB
Hi! Welcome to the IISER-Bhopal’s BioNMR lab webpage.
Traditionally biomolecular function has been primarily deduced from
their tertiary structure. Complementing other high-resolution
techniques, such as X-ray crystallography and cryo-electron
microscopy, is solution-state Nuclear Magnetic Resonance (NMR)
spectroscopy that can characterize biomolecular structure at atomic
resolution. In addition, NMR spectroscopy also has the advantage of
visualizing dynamics aiding in understanding molecular plasticity that
has been recently recognized to contribute towards diverse functions,
such as folding, aggregation, recognition, catalysis, replication,
misincorporation, damage induction/accommodation/repair, etc.
BioNMR lab at IISER-B is involved in developing and applying NMR
methodology to characterize structure and dynamics of various
biomolecules. Thermodynamic and kinetic characterization would aid in
understanding the role of structure and dynamics towards biomolecular
processes, such as effect of misincorporation/mismatches/modifications
on duplex DNA structure. In addition to existing methods, new NMR
methods are developed, implemented and applied towards structural
characterization of proteins and nucleic acids. Long-term goals
include extending the NMR methodology to study protein-nucleic acid
complexes. More details can be found in the research
and the publications
Get introduced to the lab members
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