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BLOOD ADVANCES
Characteristics, complications, and sites of bleeding among infants and toddlers less than 2 years of age with VWD. The impact of von Willebrand disease (VWD) on infants and toddlers is the focus of an interesting study by Dupervil and colleagues. This paper highlights some of the clinical implications of this disorder in early life andfocuses
VACCINATIONS IN CLL: IMPLICATIONS FOR COVID-19 Variables to consider when studying the efficacy of COVID-19 vaccine in patients with CLL. IVIG, intravenous immunoglobulin. Despite recent advancements in the treatment of CLL, our understanding of the potential impact of novel agents on the immune response to vaccinations is limited. Suboptimal humoral response to vaccinationhas been
MANUSCRIPT SUBMISSION Manuscript Submission. Author membership in the American Society of Hematology is not a prerequisite for submission or publication in Blood and is not taken into consideration during the peer review process.. All manuscripts must be submitted online through eJournalPress. Blood does not accept submissions unless they are made online through this site. If you have not used this website before TOWARDS PREVENTION OF CHILDHOOD ALL BY EARLY-LIFE IMMUNE B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common form of childhood cancer. Chemotherapy is associated withlife-long
HOW TO APPROACH THROMBOCYTOPENIA Thrombocytopenia is defined as a platelet count below the 2.5th lower percentile of the normal platelet count distribution. Results of the third US National Health and Nutrition Examination Survey (NHANES III) support the traditional value of 150 × 10 9 /L as the lower limit of normal. 1 However, platelet counts between 100 and 150 × 10 9 /L do not necessarily indicate disease if they have DETERMINING THE RECOMMENDED DOSE OF PACRITINIB: RESULTS3 Pacritinib is a novel inhibitor of JAK2, interleukin-1 receptor-associated kinase 1 (IRAK1), FLT3, and CSF-1R that has demonstrated clinical benefit in patients with myelofibrosis compared with best available therapy in PERSIST-1 and PERSIST-2 phase 3 studies. 1,2 Unlike the JAK inhibitors that are currently approved in the United States for myelofibrosis (ruxolitinib and fedratinib HAVEN 2 UPDATED ANALYSIS: MULTICENTER, OPEN-LABEL, PHASE 357 HAVEN 2 Updated Analysis: Multicenter, Open-Label, Phase 3 Study to Evaluate Efficacy, Safety and Pharmacokinetics of Subcutaneous Administration of Emicizumab Prophylaxis in Pediatric Patients with Hemophilia A with Inhibitors INTRODUCTION TO A HOW I TREAT SERIES ON ANEMIA A representation of the human erythron and an illustration of common mechanisms of anemia. This figure is intended to help the reader better understand the treatment of disease-related and perisurgical anemias considered in the “How I Treat” series of this issue of Blood; that is: renal anemia, anemia in heart failure, anemia in cancer, and anemia in the perisurgical setting. THE END OF LIFE FOR PATIENTS WITH ACUTE MYELOID LEUKEMIA Judy Foster, Traci M. Blonquist, Areej El-Jawahri, Amir T Fathi, Philip C. Amrein, Hossein Sadrzadeh, Andrew M. Brunner, Gabriella Hobbs, Eyal C. Attar, Donna S Neuberg, Karen K. Ballen; The End of Life for Patients with Acute Myeloid Leukemia (AML)- a Single CenterExperience.
APIXABAN IS SAFE AND EFFECTIVE IN MORBIDLY OBESE PATIENTS Background: In patients with venous thromboembolism (VTE), warfarin had been considered standard of care until the new direct oral anticoagulants (DOACs) were developed. Studies in patients with acute VTE and non-valvular atrial fibrillation (AF) have shown comparable therapeutic efficacy and a similar or lower bleeding risk for DOACs when compared to warfarin.BLOOD ADVANCES
Characteristics, complications, and sites of bleeding among infants and toddlers less than 2 years of age with VWD. The impact of von Willebrand disease (VWD) on infants and toddlers is the focus of an interesting study by Dupervil and colleagues. This paper highlights some of the clinical implications of this disorder in early life andfocuses
VACCINATIONS IN CLL: IMPLICATIONS FOR COVID-19 Variables to consider when studying the efficacy of COVID-19 vaccine in patients with CLL. IVIG, intravenous immunoglobulin. Despite recent advancements in the treatment of CLL, our understanding of the potential impact of novel agents on the immune response to vaccinations is limited. Suboptimal humoral response to vaccinationhas been
MANUSCRIPT SUBMISSION Manuscript Submission. Author membership in the American Society of Hematology is not a prerequisite for submission or publication in Blood and is not taken into consideration during the peer review process.. All manuscripts must be submitted online through eJournalPress. Blood does not accept submissions unless they are made online through this site. If you have not used this website before TOWARDS PREVENTION OF CHILDHOOD ALL BY EARLY-LIFE IMMUNE B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common form of childhood cancer. Chemotherapy is associated withlife-long
HOW TO APPROACH THROMBOCYTOPENIA Thrombocytopenia is defined as a platelet count below the 2.5th lower percentile of the normal platelet count distribution. Results of the third US National Health and Nutrition Examination Survey (NHANES III) support the traditional value of 150 × 10 9 /L as the lower limit of normal. 1 However, platelet counts between 100 and 150 × 10 9 /L do not necessarily indicate disease if they have DETERMINING THE RECOMMENDED DOSE OF PACRITINIB: RESULTS3 Pacritinib is a novel inhibitor of JAK2, interleukin-1 receptor-associated kinase 1 (IRAK1), FLT3, and CSF-1R that has demonstrated clinical benefit in patients with myelofibrosis compared with best available therapy in PERSIST-1 and PERSIST-2 phase 3 studies. 1,2 Unlike the JAK inhibitors that are currently approved in the United States for myelofibrosis (ruxolitinib and fedratinib HAVEN 2 UPDATED ANALYSIS: MULTICENTER, OPEN-LABEL, PHASE 357 HAVEN 2 Updated Analysis: Multicenter, Open-Label, Phase 3 Study to Evaluate Efficacy, Safety and Pharmacokinetics of Subcutaneous Administration of Emicizumab Prophylaxis in Pediatric Patients with Hemophilia A with Inhibitors INTRODUCTION TO A HOW I TREAT SERIES ON ANEMIA A representation of the human erythron and an illustration of common mechanisms of anemia. This figure is intended to help the reader better understand the treatment of disease-related and perisurgical anemias considered in the “How I Treat” series of this issue of Blood; that is: renal anemia, anemia in heart failure, anemia in cancer, and anemia in the perisurgical setting. THE END OF LIFE FOR PATIENTS WITH ACUTE MYELOID LEUKEMIA Judy Foster, Traci M. Blonquist, Areej El-Jawahri, Amir T Fathi, Philip C. Amrein, Hossein Sadrzadeh, Andrew M. Brunner, Gabriella Hobbs, Eyal C. Attar, Donna S Neuberg, Karen K. Ballen; The End of Life for Patients with Acute Myeloid Leukemia (AML)- a Single CenterExperience.
APIXABAN IS SAFE AND EFFECTIVE IN MORBIDLY OBESE PATIENTS Background: In patients with venous thromboembolism (VTE), warfarin had been considered standard of care until the new direct oral anticoagulants (DOACs) were developed. Studies in patients with acute VTE and non-valvular atrial fibrillation (AF) have shown comparable therapeutic efficacy and a similar or lower bleeding risk for DOACs when compared to warfarin. BLOOD | AMERICAN SOCIETY OF HEMATOLOGY Blood Podcast: Season 2, Episode 18. In this week’s episode, we will review a prospective study suggesting that eculizumab discontinuation based on complement genetics is a reasonable and safe strategy in patients with atypical hemolytic uremic syndrome, examine a study that provides new insights into resistance mechanisms and immune evasion APOLLO: PHASE 3 RANDOMIZED STUDY OF SUBCUTANEOUS Meletios A. Dimopoulos, Evangelos Terpos, Mario Boccadoro, Sosana Delimpasi, Meral Beksac, Eirini Katodritou, Philippe Moreau, Luca Baldini, Argiris Symeonidis, Jelena Bila, Albert Oriol, Maria-Victoria Mateos, Hermann Einsele, Ioannis Orfanidis, Tahamtan Ahmadi, Jon Ukropec, Tobias Kampfenkel, Jordan Schecter, Yanping Qiu, Himal Amin, Jessica Vermeulen, Robin Carson, Pieter UPDATES IN INFECTION RISK AND MANAGEMENT IN ACUTE LEUKEMIA FN occurs in >80% of patients undergoing chemotherapy for acute leukemia. Despite improved diagnostic abilities in the last decade, an infectious etiology is identified inDetails
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