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EMERGING TECHNOLOGY
Tags: Emerging Technology, Molecular Diagnostics, Digital Imaging, Cancer. Author: Jeff Meeusen, PhD, DABCC. The notion of better together underlies the success of metabolomics in clinical diagnostics. Where a single marker is often insufficient to distinguish disease, the combinatorial power of several related biomarkers can provide increased KEY TESTS FOR SARCOIDOSIS DIAGNOSIS AND MANAGEMENT To identify the manifestations of sarcoidosis, the American Thoracic Society (ATS) is recommending four key lab tests to screen for renal sarcoidosis, abnormal calcium metabolism, hepatic sarcoidosis, and hematological abnormalities. Sarcoidosis often involves the lungs or chest lymph nodes, “but otherwise has unpredictable clinicalfeatures.
NEWBORN SCREENING
Newborn screening programs may measure total galactose, galactose-1-phosphate, and/or decreased GALT enzyme to detect galactosemia. Results are affected by feeding status and diet (galactose and galactose-1-phosphate) and transfusions (GALT enzyme activity). False negatives may result from specimens exposed to extreme heat or delayed submission THE EVOLUTION OF DESIGNER BENZODIAZEPINES MANAGING REAGENT LOT TO LOT VARIABILITY Slide 3: Reagent Lot-to-Lot Variation. Reagent lot-to-lot variation may be defined as a change in the analytical performance of a reagent from one production lot to the next. Here we use the term “lot” to mean a batch of reagent produced by the manufacturer under uniform conditions, and passing as a unit through the same series ofprocesses.
FACING THE DIABETES CRISIS According to the CDC, 30.3 million people—or 9.4 % of the U.S. population—had diabetes in 2015, and in the same year, about 1.5 million new cases of diabetes were diagnosed among adults age 18 or older. The CDC also estimates that 33.9% of U.S. adults hadprediabetes.
WHAT IS PSEUDOHYPERKALEMIA AND WHAT SHOULD LABS DO ABOUT Distinguishing true hyperkalemia from pseudohyperkalemia is important for both laboratories and clinicians alike. One of the most common causes of pseudohyperkalemia is hemolysis of red blood cells during collection. Fortunately, hemolysis of red blood cells is easily and routinely detected by chemistry platforms colorimetrically and results 2021 AACC ANNUAL SCIENTIFIC MEETING & CLINICAL LAB EXPO Registration Is Open. Every year, the global laboratory medicine community comes together as one at the AACC Annual Scientific Meeting & Clinical Lab Expo to collaborate and create system-wide changes that improve patient outcomes and quality of life for all. HOW EUROPE’S NEW IVD REGULATIONS WILL IMPACT LABS FUNDAMENTALS OF MOLECULAR PATHOLOGY A self-paced online learning program that presents laboratorians with the essentials of molecular pathology in nine different areas including Techniques, Genetics, Infectious Diseases, Hematopathology, Solid tumors, Pharmacogenetics, and Lab Practices. Content is presented at the basic to intermediate level. Program is for individual registration and grants 13 CE credits.EMERGING TECHNOLOGY
Tags: Emerging Technology, Molecular Diagnostics, Digital Imaging, Cancer. Author: Jeff Meeusen, PhD, DABCC. The notion of better together underlies the success of metabolomics in clinical diagnostics. Where a single marker is often insufficient to distinguish disease, the combinatorial power of several related biomarkers can provide increased KEY TESTS FOR SARCOIDOSIS DIAGNOSIS AND MANAGEMENT To identify the manifestations of sarcoidosis, the American Thoracic Society (ATS) is recommending four key lab tests to screen for renal sarcoidosis, abnormal calcium metabolism, hepatic sarcoidosis, and hematological abnormalities. Sarcoidosis often involves the lungs or chest lymph nodes, “but otherwise has unpredictable clinicalfeatures.
NEWBORN SCREENING
Newborn screening programs may measure total galactose, galactose-1-phosphate, and/or decreased GALT enzyme to detect galactosemia. Results are affected by feeding status and diet (galactose and galactose-1-phosphate) and transfusions (GALT enzyme activity). False negatives may result from specimens exposed to extreme heat or delayed submission THE EVOLUTION OF DESIGNER BENZODIAZEPINES MANAGING REAGENT LOT TO LOT VARIABILITY Slide 3: Reagent Lot-to-Lot Variation. Reagent lot-to-lot variation may be defined as a change in the analytical performance of a reagent from one production lot to the next. Here we use the term “lot” to mean a batch of reagent produced by the manufacturer under uniform conditions, and passing as a unit through the same series ofprocesses.
FACING THE DIABETES CRISIS According to the CDC, 30.3 million people—or 9.4 % of the U.S. population—had diabetes in 2015, and in the same year, about 1.5 million new cases of diabetes were diagnosed among adults age 18 or older. The CDC also estimates that 33.9% of U.S. adults hadprediabetes.
WHAT IS PSEUDOHYPERKALEMIA AND WHAT SHOULD LABS DO ABOUT Distinguishing true hyperkalemia from pseudohyperkalemia is important for both laboratories and clinicians alike. One of the most common causes of pseudohyperkalemia is hemolysis of red blood cells during collection. Fortunately, hemolysis of red blood cells is easily and routinely detected by chemistry platforms colorimetrically and results VIDEOS: CORONAVIRUS TESTING IN A POST-VACCINE WORLD As coronavirus vaccines become more widely available, clinical laboratory testing continues to play a vital role in managing the pandemic, working in tandem withLOGIN - AACC.ORG
Login with your email address to access your AACC content. Don’t already have an account? Go to “Create an account” below. If you are interested in the AACC Member Directory, this benefit is available exclusively to AACC members. FUNDAMENTALS OF MOLECULAR PATHOLOGY A self-paced online learning program that presents laboratorians with the essentials of molecular pathology in nine different areas including Techniques, Genetics, Infectious Diseases, Hematopathology, Solid tumors, Pharmacogenetics, and Lab Practices. Content is presented at the basic to intermediate level. Program is for individual registration and grants 13 CE credits. CRITICAL VALUE CHANGE Critical Value Change. In January 2019, the American Diabetes Association (ADA) in its annual standards of medical care in diabetes released new guidance, classifying level 2 hypoglycemia as a glucose value 1.8 million patients worldwide per year. • Sepsis accounts for >200,000 deaths each year AACC - AMERICAN ASSOCIATION FOR CLINICAL CHEMISTRYLOGINCOMMUNITYSCIENCE & RESEARCHCLINICAL LABORATORY NEWSEDUCATIONMEETINGS Better Health Through Laboratory Medicine. AACC is a global scientific and medical professional organization dedicated to clinical laboratory science and its application to healthcare. Our leadership in education, advocacy and collaboration helps lab professionals adapt to change and do what they do best: provide vital insight and guidance so patients get the care they need. 2021 AACC ANNUAL SCIENTIFIC MEETING & CLINICAL LAB EXPO Registration Is Open. Every year, the global laboratory medicine community comes together as one at the AACC Annual Scientific Meeting & Clinical Lab Expo to collaborate and create system-wide changes that improve patient outcomes and quality of life for all. 2021 AACC ANNUAL SCIENTIFIC MEETING AND CLINICAL LAB EXPO The 2021 AACC Annual Scientific Meeting & Clinical Lab Expo will showcase the cutting-edge science and technology shaping the future of laboratory medicine. Join us at the Georgia World Congress Center in Atlanta, September 26-30. Register today. Held in partnership this year with the Canadian Society of Clinical Chemists. 300+. EXPERTSPEAKERS.
ALL BOOKS | AACC.ORG Author: Alan Wu. A rogue chemist creates an empire to support the needs of illegal drug users consisting of athletes seeking to enhance performance, women trying to stay young, men trying to stay virile, and drug addicts trying to avoid detection. This is an eye-opening HOW EUROPE’S NEW IVD REGULATIONS WILL IMPACT LABSHOME - AACC ARTERY
@Alma Alfonzo, ASCP, MT (ASCP) and @Danyel Tacker, PhD, DABCC, FAACC Good news for us! Maybe for you as well. Check with your supplier. We now have blue top tubes.EMERGING TECHNOLOGY
Tags: Emerging Technology, Molecular Diagnostics, Digital Imaging, Cancer. Author: Jeff Meeusen, PhD, DABCC. The notion of better together underlies the success of metabolomics in clinical diagnostics. Where a single marker is often insufficient to distinguish disease, the combinatorial power of several related biomarkers can provide increased KEY TESTS FOR SARCOIDOSIS DIAGNOSIS AND MANAGEMENT To identify the manifestations of sarcoidosis, the American Thoracic Society (ATS) is recommending four key lab tests to screen for renal sarcoidosis, abnormal calcium metabolism, hepatic sarcoidosis, and hematological abnormalities. Sarcoidosis often involves the lungs or chest lymph nodes, “but otherwise has unpredictable clinicalfeatures.
POINT-OF-CARE SPECIALIST A self-paced online learning program developed to prepare POC coordinators and those responsible for POCT for their critical role and to promote standardized best practices within and outside of the US. Courses are focused on program operation and cover Administration, Communication, Connectivity, Training, Instrument Selection, Policies and Procedures, Quality Management, and Regulations. SEPSIS AND THE CLINICAL LABORATORY Sepsis Background and Significance • Sepsis affects >750,000 American and >1.8 million patients worldwide per year. • Sepsis accounts for >200,000 deaths each yearAACC PRESS RELEASES
DEC.13.2020. During the all-virtual 2020 AACC Annual Scientific Meeting & Clinical Lab Expo, leading scientific experts will dive into the groundbreaking advances that are the future of cancer care. One plenary session will focus on the cutting-edge treatment known as T cell therapy, while another will showcase recent discoveries abouttumor.
AACC LEARNING LAB
AACC Learning Lab is led by renowned experts and Editors-in-Chief, Drs. Nader Rifai and Christina Ellervik, and developed by experts across the fields of clinical chemistry. The material will cover all disciplines of laboratory medicine in the following areas: General Laboratory Medicine. Clinical Chemistry.LOGIN - AACC.ORG
Login with your email address to access your AACC content. Don’t already have an account? Go to “Create an account” below. If you are interested in the AACC Member Directory, this benefit is available exclusively to AACC members. CLINICAL LABORATORY NEWS AACC’s flagship and award winning monthly news magazine, CLN is the authoritative source for timely analysis of issues and trends affecting clinical laboratories. It’s also rated the #1 CLINICAL CASE STUDIES Case Study. NOV.5.2020. A Case of Rapid Deterioration with Marked Hypergammaglobulinemia. NOV.5.2020. Clinical Chemistry. Clinical Chemistry. A 30-year-old male was referred to Hematologic Oncology after 6 months of worsening lymphadenopathy and symptoms of fatigue, night sweats, weight loss, and shortness of breath. POINT-OF-CARE SPECIALIST A self-paced online learning program developed to prepare POC coordinators and those responsible for POCT for their critical role and to promote standardized best practices within and outside of the US. Courses are focused on program operation and cover Administration, Communication, Connectivity, Training, Instrument Selection, Policies and Procedures, Quality Management, and Regulations. INTEROPERABILITY: COVID-19 AS AN IMPETUS FOR CHANGE Article. Dina N Greene, David S McClintock, and Thomas JS Durant.Interoperability: COVID-19 as an Impetus for Change Clin Chem 2021; 67:4 592–95.. Guest. Dr. Thomas Durant is an assistant professor of laboratory medicine and informatics researcher at the Yale School of Medicine and the Medical Director of Chemical Pathology and Laboratory Information Technology at Yale New Haven LAB VALUES THAT GO AWRY IN COVID-19 A meta-analysis of 35 studies pinpoints the lab values that could help predict the course of SARS-CoV-2 infection. Lymphocytes, C-reactive protein (CRP), procalcitonin (PCT), D-dimer, and other inflammatory, organ function, and cardiac markers might flag risk and poor outcomesin
AACC ISSUES GUIDANCE ON THE USES AND LIMITATIONS OF TESTS A number of clinical laboratory tests exist for the prediction of premature birth, but there is no consensus in the medical community on how effective these tests are and how they should be used in clinical practice. To bring much-needed clarity to this subject, AACC has issued a new guidance document that advises against the routine use of these tests, citing evidence showing that the tests CLINICAL CHEMISTRY TRAINEE COUNCIL The Clinical Chemistry Trainee Council serves as a unique program for residents and fellows in laboratory medicine by providing them with free educational materials and interactive tools to help and guide them to a successful career. AACC uses Cookies to ensure the best website experience. Continuing without changing Cookie settings assumes you consent to our use of cookies on this device. You can change these settings at any time, but that may impair functionality on our websites. Review our cookie andprivacy policy
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CORONAVIRUS RESOURCES FOR LABS AACC has gathered essential information and resources to help laboratories with coronavirus testing—and to stay prepared for when new infectious diseases inevitably emerge in the future. (Imagecredit: CDC)
Learn more
VARIANT CALLS IN THE GENOMIC MEDICINE ERA Fast-changing information is prompting laboratories to review their duty to reinterpret and recontact providers and patients. (Image credit: sanjeri / Getty Images)Read more
AACC URGES CAUTION ON HOME SAMPLE COLLECTION FOR COVID-19 Now that FDA has authorized the first at-home sample collection kit for COVID-19 testing, AACC is warning that more evidence is needed before the country can rely on home-based kits.Read more
AACC LAUNCHES VIDEOS EXPLAINING COVID-19 TESTING To address some of the confusion surrounding COVID-19 testing, AACC has launched a video series in which the association’s leading laboratory experts answer common questions about tests for thepandemic.
Watch the videos
AACC CONGRATULATES 2020 AWARD WINNERS AACC is pleased to announce the recipients of the 2020 AACC and AACC Academy Awards, who have made exceptional contributions to the field of laboratory medicine through research, service, and education.Learn more
CORONAVIRUS RESOURCES FOR LABS AACC has gathered essential information and resources to help laboratories with coronavirus testing—and to stay prepared for when new infectious diseases inevitably emerge in the future. (Imagecredit: CDC)
Learn more
VARIANT CALLS IN THE GENOMIC MEDICINE ERA Fast-changing information is prompting laboratories to review their duty to reinterpret and recontact providers and patients. (Image credit: sanjeri / Getty Images)Read more
AACC URGES CAUTION ON HOME SAMPLE COLLECTION FOR COVID-19 Now that FDA has authorized the first at-home sample collection kit for COVID-19 testing, AACC is warning that more evidence is needed before the country can rely on home-based kits.Read more
AACC LAUNCHES VIDEOS EXPLAINING COVID-19 TESTING To address some of the confusion surrounding COVID-19 testing, AACC has launched a video series in which the association’s leading laboratory experts answer common questions about tests for thepandemic.
Watch the videos
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IN CLINICAL CHEMISTRY RAPID DETECTION OF COVID-19 USING AN RT-LAMP DIAGNOSTIC PLATFORM Scientists have developed a new, faster molecular method to detect SARS-CoV-2 that may allow greater access to testing around the globe.Read the study
FEATURED AACC ARTERY SOLUTION ALGORITHMS FOR THE USE OF COVID AB TESTING A lab professional is wondering if anyone can share an algorithm for the use of COVID antibody testing. Most respondents agree, however, that until the question of immunity is answered (i.e. is the antibody response protective from re-infection and for how long?), antibody tests for SARS-CoV-2 have limited clinical utility. Currently, these tests’ main clinical uses are: 1) as a complementary test to a negative PCR in a critically ill patient and 2) for identifying recovered patients who could be convalescent plasma donors. Find the answer to your question IN THE JOURNAL OF APPLIED LABORATORY MEDICINE COVID-19 IN PEDIATRICS Biochemical findings in children, along with levels of cytokines, T-cell responses, and assessment of antibody titres in this population, may offer insights into SARS-CoV-2 infection.Read more
FEATURED AACC WEBINAR SARS COV-2: RISING TO THE TESTING CHALLENGE IN THE U.S. This upcoming AACC webinar will discuss FDA’s emergency use authorization (EUA) process for SARS-CoV-2 tests and the molecular tests that have received EUAs to date, as well as serological assays, current biomarkers, and potential therapies for COVID-19.Learn more
IN CLINICAL LABORATORY NEWS BEST PRACTICES FOR DIAGNOSING SYSTEMIC AUTOINFLAMMATORY DISEASES Updated guidelines reflect broad use of next-generation sequencing, newly identified causative genes, and evolved understanding of inheritance patterns for rare diseases with overlapping symptoms.Read more
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ABOUT AACC
AACC is a global scientific and medical professional organization dedicated to clinical laboratory science and its application to healthcare. Our leadership in education, advocacy and collaboration helps lab professionals adapt to change and do what they do best: provide vital insight and guidance so patients get the care they need.Learn More
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