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GlycoCalyx

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* Publications
* Current Projects
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GLYCOCALYX, PROTECTIVE COMPARTMENT IN BLOOD VESSELS

 

The endothelial glycocalyx is a gel-like layer at the luminal side of
endothelial cells lining the blood vessels throughout the body.
Research studies from our team and other groups have shown that the
endothelial glycocalyx plays an important role in protection of the
vascular system against atherogenic challenges associated with
cardiovascular disease.  Also, the glycocalyx is involved in the
physiological regulation of organ perfusion, which is important for an
effective delivery of nutrients and hormones to their target cells.

 

Ongoing experimental and clinical research projects aim to evaluate
whether perturbation of the endothelial glycocalyx is an important
initial step towards the development of cardiovascular disease, and
includes the development of diagnostic tools to detect glycocalyx
degradation in humans at risk, as well as evaluation of targeted
interventions to alleviate glycocalyx loss.  In addition, our
research aims at a better understanding of the physiological and
molecular processes involved in control of vascular homeostasis and
organ perfusion by the glycocalyx.

 

We hope this website will give you appreciation of the challenges we
are facing in understanding the many roles of the endothelial
glycocalyx in our vascular system, and that it will trigger your
curiosity about the potential clinical and physiological implications
of this fascinating compartment.

 

Hans Vink 

Jurgen Van Teeffelen

 

 

DO YOU WANT TO KNOW MORE ABOUT OUR TEAM?

Our team »

 
 

 

TAKE A LOOK AT OUR LATEST PUBLICATIONS

 

Publications »

 








 

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